1293592:LCU RS08795
gene id: 1293592:LCU_RS08795
uniprot id: A0A8E2XAB2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

1293592:LCU RS00175
gene id: 1293592:LCU_RS00175
uniprot id: A0A8E2XAN2
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

1293592:LCU RS03530
gene id: 1293592:LCU_RS03530
uniprot id: A0A8E2XAZ1
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS07895
gene id: 1293592:LCU_RS07895
uniprot id: A0A8E2XA80
names: Similarity
messages: Belongs to the ParB family.

1293592:LCU RS05660
gene id: 1293592:LCU_RS05660
uniprot id: A0A8E2X9I8
names: Function
names: Similarity
messages: Belongs to the CpsD/CapB family.
messages: Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide.

1293592:LCU RS09210
gene id: 1293592:LCU_RS09210
uniprot id: A0A8E3BKY7
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS01260
gene id: 1293592:LCU_RS01260
uniprot id: A0A8E3BK15
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1293592:LCU RS01445
gene id: 1293592:LCU_RS01445
uniprot id: A0A8E2X8U2
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1293592:LCU RS01640
gene id: 1293592:LCU_RS01640
uniprot id: A0A8E3BJR6
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
messages: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.

1293592:LCU RS08080
gene id: 1293592:LCU_RS08080
uniprot id: A0A8E2X9K9
names: Caution
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS09485
gene id: 1293592:LCU_RS09485
uniprot id: A0A8E3BLX1
names: Similarity
messages: Belongs to the UPF0297 family.

1293592:LCU RS09150
gene id: 1293592:LCU_RS09150
uniprot id: A0A8E2XAF1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1293592:LCU RS02725
gene id: 1293592:LCU_RS02725
uniprot id: A0A8E2X8N8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

1293592:LCU RS01200
gene id: 1293592:LCU_RS01200
uniprot id: A0A8E3BKI2
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1293592:LCU RS00425
gene id: 1293592:LCU_RS00425
uniprot id: A0A8E2X7G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

1293592:LCU RS06550
gene id: 1293592:LCU_RS06550
uniprot id: A0A8E2XA24
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1293592:LCU RS01595
gene id: 1293592:LCU_RS01595
uniprot id: A0A8E2X862
names: Function
names: Similarity
messages: Belongs to the aldose epimerase family.
messages: Catalyzes the interconversion of alpha and beta anomers of maltose.

1293592:LCU RS05610
gene id: 1293592:LCU_RS05610
uniprot id: A0A8E2X903
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

1293592:LCU RS05360
gene id: 1293592:LCU_RS05360
uniprot id: A0A8E2X8N4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MecA family.
messages: Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
messages: Homodimer.
messages: The N-terminal domain probably binds unfolded/aggregated proteins; the C-terminal domain interacts with ClpC.

1293592:LCU RS00435
gene id: 1293592:LCU_RS00435
uniprot id: A0A8E3BJW3
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

1293592:LCU RS06325
gene id: 1293592:LCU_RS06325
uniprot id: A0A8E3BKW6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1293592:LCU RS04915
gene id: 1293592:LCU_RS04915
uniprot id: A0A8E3BL48
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1293592:LCU RS05795
gene id: 1293592:LCU_RS05795
uniprot id: A0A8E3BJL0
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

1293592:LCU RS04430
gene id: 1293592:LCU_RS04430
uniprot id: A0A8E3BKK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1293592:LCU RS06170
gene id: 1293592:LCU_RS06170
uniprot id: A0A8E3BJN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1293592:LCU RS08170
gene id: 1293592:LCU_RS08170
uniprot id: A0A8E2X9U7
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS08315
gene id: 1293592:LCU_RS08315
uniprot id: A0A8E2XAC6
names: Similarity
messages: Belongs to the Dps family.

1293592:LCU RS09760
gene id: 1293592:LCU_RS09760
uniprot id: A0A8E2XAC3
names: Similarity
messages: Belongs to the CFA/CMAS family.

1293592:LCU RS03600
gene id: 1293592:LCU_RS03600
uniprot id: A0A8E2X8A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1293592:LCU RS05170
gene id: 1293592:LCU_RS05170
uniprot id: A0A8E2X8L4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

1293592:LCU RS01100
gene id: 1293592:LCU_RS01100
uniprot id: A0A8E3BJN2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS03355
gene id: 1293592:LCU_RS03355
uniprot id: A0A8E2X7Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

1293592:LCU RS05510
gene id: 1293592:LCU_RS05510
uniprot id: A0A8E2X9H0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1293592:LCU RS08210
gene id: 1293592:LCU_RS08210
uniprot id: A0A8E3BJY5
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

1293592:LCU RS06365
gene id: 1293592:LCU_RS06365
uniprot id: A0A8E2X908
names: Function
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

1293592:LCU RS06725
gene id: 1293592:LCU_RS06725
uniprot id: A0A8E2X9N3
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1293592:LCU RS01220
gene id: 1293592:LCU_RS01220
uniprot id: A0A8E2X796
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1293592:LCU RS05905
gene id: 1293592:LCU_RS05905
uniprot id: A0A8E2XA88
names: Similarity
messages: Belongs to the glycosyl hydrolase 73 family.

1293592:LCU RS06265
gene id: 1293592:LCU_RS06265
uniprot id: A0A8E2X9Q8
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS03245
gene id: 1293592:LCU_RS03245
uniprot id: A0A8E2X8J8
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS07360
gene id: 1293592:LCU_RS07360
uniprot id: A0A8E3BKM6
names: Similarity
messages: Belongs to the TPP enzyme family.

1293592:LCU RS07815
gene id: 1293592:LCU_RS07815
uniprot id: A0A8E2XA69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS09500
gene id: 1293592:LCU_RS09500
uniprot id: A0A8E2XBC4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family. RnhC subfamily.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1293592:LCU RS07945
gene id: 1293592:LCU_RS07945
uniprot id: A0A8E3BL58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

1293592:LCU RS08225
gene id: 1293592:LCU_RS08225
uniprot id: A0A8E2XA52
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS09355
gene id: 1293592:LCU_RS09355
uniprot id: A0A8E2XA40
names: Similarity
messages: Belongs to the UPF0177 family.

1293592:LCU RS02605
gene id: 1293592:LCU_RS02605
uniprot id: A0A8E2X7P4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

1293592:LCU RS01490
gene id: 1293592:LCU_RS01490
uniprot id: A0A8E3BK27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1293592:LCU RS05075
gene id: 1293592:LCU_RS05075
uniprot id: A0A8E2X964
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcAL family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS04030
gene id: 1293592:LCU_RS04030
uniprot id: A0A8E3BKH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

1293592:LCU RS01590
gene id: 1293592:LCU_RS01590
uniprot id: A0A8E2X822
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
messages: Cytoplasm

1293592:LCU RS01910
gene id: 1293592:LCU_RS01910
uniprot id: A0A8E2X8A2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1293592:LCU RS07375
gene id: 1293592:LCU_RS07375
uniprot id: A0A8E2XAT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

1293592:LCU RS01990
gene id: 1293592:LCU_RS01990
uniprot id: A0A8E3BK63
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1293592:LCU RS06645
gene id: 1293592:LCU_RS06645
uniprot id: A0A8E3BKY3
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS08630
gene id: 1293592:LCU_RS08630
uniprot id: A0A8E2XCA2
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1293592:LCU RS09010
gene id: 1293592:LCU_RS09010
uniprot id: A0A8E2X9X4
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS07885
gene id: 1293592:LCU_RS07885
uniprot id: A0A8E3BLM7
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1293592:LCU RS05665
gene id: 1293592:LCU_RS05665
uniprot id: A0A8E2XA64
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS03070
gene id: 1293592:LCU_RS03070
uniprot id: A0A8E2X8C9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS04040
gene id: 1293592:LCU_RS04040
uniprot id: A0A8E2X8U0
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1293592:LCU RS09400
gene id: 1293592:LCU_RS09400
uniprot id: A0A8E3BLD4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1293592:LCU RS09590
gene id: 1293592:LCU_RS09590
uniprot id: A0A8E2XA41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1293592:LCU RS08755
gene id: 1293592:LCU_RS08755
uniprot id: A0A8E2XAB9
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS04545
gene id: 1293592:LCU_RS04545
uniprot id: A0A8E2X8D3
names: Similarity
messages: Belongs to the UPF0145 family.

1293592:LCU RS05475
gene id: 1293592:LCU_RS05475
uniprot id: A0A8E3BKB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1293592:LCU RS03540
gene id: 1293592:LCU_RS03540
uniprot id: A0A8E2X8I6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

1293592:LCU RS08470
gene id: 1293592:LCU_RS08470
uniprot id: A0A8E2XA84
names: Similarity
messages: Belongs to the asp23 family.

1293592:LCU RS05425
gene id: 1293592:LCU_RS05425
uniprot id: A0A8E2X9F9
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

1293592:LCU RS00585
gene id: 1293592:LCU_RS00585
uniprot id: A0A8E3BJK5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1293592:LCU RS06510
gene id: 1293592:LCU_RS06510
uniprot id: A0A8E2X9T5
names: Similarity
messages: Belongs to the asparaginase 1 family.

1293592:LCU RS00545
gene id: 1293592:LCU_RS00545
uniprot id: A0A8E2X8I8
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS08680
gene id: 1293592:LCU_RS08680
uniprot id: A0A8E2XBA5
names: Similarity
messages: Belongs to the thioredoxin family.

1293592:LCU RS07680
gene id: 1293592:LCU_RS07680
uniprot id: A0A8E2X9F7
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS05690
gene id: 1293592:LCU_RS05690
uniprot id: A0A8E2XBK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1293592:LCU RS03505
gene id: 1293592:LCU_RS03505
uniprot id: A0A8E2X7Z9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated Cas9 family.
messages: Belongs to the CRISPR-associated protein Cas9 family. Subtype II-A subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA). Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs. PAM recognition is also required for catalytic activity.
messages: Has 2 endonuclease domains. The discontinuous RuvC-like domain cleaves the target DNA noncomplementary to crRNA while the HNH nuclease domain cleaves the target DNA complementary to crRNA.
messages: Monomer. Binds crRNA and tracrRNA.

1293592:LCU RS02710
gene id: 1293592:LCU_RS02710
uniprot id: A0A8E2X7R0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS07350
gene id: 1293592:LCU_RS07350
uniprot id: A0A8E2XAC0
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS06240
gene id: 1293592:LCU_RS06240
uniprot id: A0A8E3BKV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1293592:LCU RS01515
gene id: 1293592:LCU_RS01515
uniprot id: A0A8E2X852
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1293592:LCU RS05155
gene id: 1293592:LCU_RS05155
uniprot id: A0A8E2X974
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1293592:LCU RS09765
gene id: 1293592:LCU_RS09765
uniprot id: A0A8E3BLL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1293592:LCU RS09075
gene id: 1293592:LCU_RS09075
uniprot id: A0A8E2XB83
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS08995
gene id: 1293592:LCU_RS08995
uniprot id: A0A8E2XB74
names: Similarity
messages: Belongs to the BMP lipoprotein family.

1293592:LCU RS00350
gene id: 1293592:LCU_RS00350
uniprot id: A0A8E2X7F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. EmrB family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS09040
gene id: 1293592:LCU_RS09040
uniprot id: A0A8E3BKX7
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

1293592:LCU RS08300
gene id: 1293592:LCU_RS08300
uniprot id: A0A8E3BLQ3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1293592:LCU RS06130
gene id: 1293592:LCU_RS06130
uniprot id: A0A8E2X917
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

1293592:LCU RS06065
gene id: 1293592:LCU_RS06065
uniprot id: A0A8E2X9N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1293592:LCU RS05870
gene id: 1293592:LCU_RS05870
uniprot id: A0A8E3BKE2
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

1293592:LCU RS01995
gene id: 1293592:LCU_RS01995
uniprot id: A0A8E3BKN1
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

1293592:LCU RS01150
gene id: 1293592:LCU_RS01150
uniprot id: A0A8E2X7E2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1293592:LCU RS02090
gene id: 1293592:LCU_RS02090
uniprot id: A0A8E2X915
names: Similarity
messages: Belongs to the CvfB family.

1293592:LCU RS09310
gene id: 1293592:LCU_RS09310
uniprot id: A0A8E3BLD7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1293592:LCU RS01000
gene id: 1293592:LCU_RS01000
uniprot id: A0A8E2XA57
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.
messages: Belongs to the thioester dehydratase family. FabZ subfamily.

1293592:LCU RS00365
gene id: 1293592:LCU_RS00365
uniprot id: A0A8E3BIP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1293592:LCU RS04350
gene id: 1293592:LCU_RS04350
uniprot id: A0A8E3BJD0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1293592:LCU RS08195
gene id: 1293592:LCU_RS08195
uniprot id: A0A8E2XA53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS00860
gene id: 1293592:LCU_RS00860
uniprot id: A0A8E2X7L4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1293592:LCU RS02685
gene id: 1293592:LCU_RS02685
uniprot id: A0A8E2X8E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

1293592:LCU RS09135
gene id: 1293592:LCU_RS09135
uniprot id: A0A8E3BK38
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1293592:LCU RS02940
gene id: 1293592:LCU_RS02940
uniprot id: A0A8E2X8L1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1293592:LCU RS03550
gene id: 1293592:LCU_RS03550
uniprot id: A0A8E3BKE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1293592:LCU RS00890
gene id: 1293592:LCU_RS00890
uniprot id: A0A8E2X7T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

1293592:LCU RS04200
gene id: 1293592:LCU_RS04200
uniprot id: A0A8E3BKJ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1293592:LCU RS05160
gene id: 1293592:LCU_RS05160
uniprot id: A0A8E2X9D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1293592:LCU RS02075
gene id: 1293592:LCU_RS02075
uniprot id: A0A8E3BKN6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS06970
gene id: 1293592:LCU_RS06970
uniprot id: A0A8E2XBW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1293592:LCU RS08535
gene id: 1293592:LCU_RS08535
uniprot id: A0A8E2X9U6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1293592:LCU RS05740
gene id: 1293592:LCU_RS05740
uniprot id: A0A8E2XA70
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

1293592:LCU RS04465
gene id: 1293592:LCU_RS04465
uniprot id: A0A8E2X8C4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1293592:LCU RS00465
gene id: 1293592:LCU_RS00465
uniprot id: A0A8E2X7R9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

1293592:LCU RS07750
gene id: 1293592:LCU_RS07750
uniprot id: A0A8E2X9L1
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1293592:LCU RS05270
gene id: 1293592:LCU_RS05270
uniprot id: A0A8E2X8R5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.

1293592:LCU RS02115
gene id: 1293592:LCU_RS02115
uniprot id: A0A8E2XAH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpB family.
messages: Cytoplasm
messages: Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.

1293592:LCU RS06990
gene id: 1293592:LCU_RS06990
uniprot id: A0A8E3BL03
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1293592:LCU RS05775
gene id: 1293592:LCU_RS05775
uniprot id: A0A8E2X9T3
names: Similarity
messages: Belongs to the DEAD box helicase family.

1293592:LCU RS05655
gene id: 1293592:LCU_RS05655
uniprot id: A0A8E2X9C5
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

1293592:LCU RS06915
gene id: 1293592:LCU_RS06915
uniprot id: A0A8E3BKZ8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

1293592:LCU RS09510
gene id: 1293592:LCU_RS09510
uniprot id: A0A8E2XA60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

1293592:LCU RS08190
gene id: 1293592:LCU_RS08190
uniprot id: A0A8E2XAP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS03280
gene id: 1293592:LCU_RS03280
uniprot id: A0A8E2X866
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

1293592:LCU RS02010
gene id: 1293592:LCU_RS02010
uniprot id: A0A8E2X905
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1293592:LCU RS06055
gene id: 1293592:LCU_RS06055
uniprot id: A0A8E3BLB6
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

1293592:LCU RS01255
gene id: 1293592:LCU_RS01255
uniprot id: A0A8E3BJP2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1293592:LCU RS05005
gene id: 1293592:LCU_RS05005
uniprot id: A0A8E2X9Y8
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1293592:LCU RS00515
gene id: 1293592:LCU_RS00515
uniprot id: A0A8E3BJW8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1293592:LCU RS01795
gene id: 1293592:LCU_RS01795
uniprot id: A0A8E2X7X8
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

1293592:LCU RS07910
gene id: 1293592:LCU_RS07910
uniprot id: A0A8E2X9N2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1293592:LCU RS05065
gene id: 1293592:LCU_RS05065
uniprot id: A0A8E3BKP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

1293592:LCU RS01890
gene id: 1293592:LCU_RS01890
uniprot id: A0A8E3BIY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1293592:LCU RS04295
gene id: 1293592:LCU_RS04295
uniprot id: A0A8E2X898
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1293592:LCU RS02730
gene id: 1293592:LCU_RS02730
uniprot id: A0A8E2X893
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS04965
gene id: 1293592:LCU_RS04965
uniprot id: A0A8E2X922
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS04445
gene id: 1293592:LCU_RS04445
uniprot id: A0A8E2X936
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS08590
gene id: 1293592:LCU_RS08590
uniprot id: A0A8E3BLR8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mg(2+). Can also accept Mn(2+).

1293592:LCU RS06945
gene id: 1293592:LCU_RS06945
uniprot id: A0A8E2XAK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the energy-coupling factor EcfT family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane
messages: Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.

1293592:LCU RS01605
gene id: 1293592:LCU_RS01605
uniprot id: A0A8E2X7D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1293592:LCU RS04755
gene id: 1293592:LCU_RS04755
uniprot id: A0A8E3BL39
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1293592:LCU RS02260
gene id: 1293592:LCU_RS02260
uniprot id: A0A8E2X7L7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1293592:LCU RS08580
gene id: 1293592:LCU_RS08580
uniprot id: A0A8E3BK04
names: Similarity
messages: Belongs to the peptidase C69 family.

1293592:LCU RS09350
gene id: 1293592:LCU_RS09350
uniprot id: A0A8E2XA13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

1293592:LCU RS05320
gene id: 1293592:LCU_RS05320
uniprot id: A0A8E3BKQ8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CutC family.
messages: Cytoplasm
messages: Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.

1293592:LCU RS01075
gene id: 1293592:LCU_RS01075
uniprot id: A0A8E2X786
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

1293592:LCU RS01110
gene id: 1293592:LCU_RS01110
uniprot id: A0A8E3BIU0
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS04355
gene id: 1293592:LCU_RS04355
uniprot id: A0A8E3BKJ8
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS03595
gene id: 1293592:LCU_RS03595
uniprot id: A0A8E2X818
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1293592:LCU RS06215
gene id: 1293592:LCU_RS06215
uniprot id: A0A8E2X971
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

1293592:LCU RS09300
gene id: 1293592:LCU_RS09300
uniprot id: A0A8E2XAL1
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1293592:LCU RS08805
gene id: 1293592:LCU_RS08805
uniprot id: A0A8E2XB54
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1293592:LCU RS00290
gene id: 1293592:LCU_RS00290
uniprot id: A0A8E2X706
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LTA synthase family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS09685
gene id: 1293592:LCU_RS09685
uniprot id: A0A8E2XCI5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. NagD family.
messages: Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro.
messages: Divalent metal ions. Mg(2+) is the most effective.

1293592:LCU RS01970
gene id: 1293592:LCU_RS01970
uniprot id: A0A8E3BJT2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1293592:LCU RS01295
gene id: 1293592:LCU_RS01295
uniprot id: A0A8E2X7A5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1293592:LCU RS08520
gene id: 1293592:LCU_RS08520
uniprot id: A0A8E2XAE1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

1293592:LCU RS05305
gene id: 1293592:LCU_RS05305
uniprot id: A0A8E3BKB1
names: Similarity
messages: Belongs to the glycosyl hydrolase 73 family.

1293592:LCU RS07080
gene id: 1293592:LCU_RS07080
uniprot id: A0A8E3BLH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1293592:LCU RS01430
gene id: 1293592:LCU_RS01430
uniprot id: A0A8E3BKJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

1293592:LCU RS09395
gene id: 1293592:LCU_RS09395
uniprot id: A0A8E3BK51
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1293592:LCU RS06790
gene id: 1293592:LCU_RS06790
uniprot id: A0A8E2X996
names: Similarity
messages: Belongs to the thioredoxin family.

1293592:LCU RS06235
gene id: 1293592:LCU_RS06235
uniprot id: A0A8E3BKG1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1293592:LCU RS08255
gene id: 1293592:LCU_RS08255
uniprot id: A0A8E2XB06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Cell envelope
messages: Releases the N-terminal proline from various substrates.

1293592:LCU RS07460
gene id: 1293592:LCU_RS07460
uniprot id: A0A8E3BL31
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

1293592:LCU RS09460
gene id: 1293592:LCU_RS09460
uniprot id: A0A8E2XAM8
names: Similarity
messages: Belongs to the thioester dehydratase family. FabZ subfamily.

1293592:LCU RS07905
gene id: 1293592:LCU_RS07905
uniprot id: A0A8E2X9J0
names: Similarity
messages: Belongs to the ParB family.

1293592:LCU RS03665
gene id: 1293592:LCU_RS03665
uniprot id: A0A8E2X873
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS05535
gene id: 1293592:LCU_RS05535
uniprot id: A0A8E2X8Z3
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1293592:LCU RS02340
gene id: 1293592:LCU_RS02340
uniprot id: A0A8E2X7M6
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

1293592:LCU RS05575
gene id: 1293592:LCU_RS05575
uniprot id: A0A8E3BL90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS09785
gene id: 1293592:LCU_RS09785
uniprot id: A0A8E3BKP7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1293592:LCU RS07035
gene id: 1293592:LCU_RS07035
uniprot id: A0A8E2X989
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1293592:LCU RS04290
gene id: 1293592:LCU_RS04290
uniprot id: A0A8E2X9R6
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

1293592:LCU RS06260
gene id: 1293592:LCU_RS06260
uniprot id: A0A8E2X9J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

1293592:LCU RS09420
gene id: 1293592:LCU_RS09420
uniprot id: A0A8E2XBB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1293592:LCU RS06125
gene id: 1293592:LCU_RS06125
uniprot id: A0A8E2X8X8
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1293592:LCU RS01030
gene id: 1293592:LCU_RS01030
uniprot id: A0A8E3BIT6
names: Similarity
messages: Belongs to the universal stress protein A family.

1293592:LCU RS01450
gene id: 1293592:LCU_RS01450
uniprot id: A0A8E2X7C4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1293592:LCU RS01195
gene id: 1293592:LCU_RS01195
uniprot id: A0A8E3BK16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

1293592:LCU RS09185
gene id: 1293592:LCU_RS09185
uniprot id: A0A8E2XA66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Cell membrane
messages: H(+)-stimulated, divalent metal cation uptake system.

1293592:LCU RS02150
gene id: 1293592:LCU_RS02150
uniprot id: A0A8E3BK71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1293592:LCU RS00430
gene id: 1293592:LCU_RS00430
uniprot id: A0A8E3BJJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1293592:LCU RS02950
gene id: 1293592:LCU_RS02950
uniprot id: A0A8E2X7T2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1293592:LCU RS01360
gene id: 1293592:LCU_RS01360
uniprot id: A0A8E2X833
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1293592:LCU RS03605
gene id: 1293592:LCU_RS03605
uniprot id: A0A8E2XB01
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1293592:LCU RS02735
gene id: 1293592:LCU_RS02735
uniprot id: A0A8E3BJW9
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS01885
gene id: 1293592:LCU_RS01885
uniprot id: A0A8E3BK53
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1293592:LCU RS02195
gene id: 1293592:LCU_RS02195
uniprot id: A0A8E2XAL0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1293592:LCU RS01380
gene id: 1293592:LCU_RS01380
uniprot id: A0A8E2X7C3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1293592:LCU RS06720
gene id: 1293592:LCU_RS06720
uniprot id: A0A8E2XA46
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS06620
gene id: 1293592:LCU_RS06620
uniprot id: A0A8E2X9B7
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1293592:LCU RS04740
gene id: 1293592:LCU_RS04740
uniprot id: A0A8E3BKM0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1293592:LCU RS03230
gene id: 1293592:LCU_RS03230
uniprot id: A0A8E3BJ64
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1293592:LCU RS00225
gene id: 1293592:LCU_RS00225
uniprot id: A0A8E2X9W3
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS04855
gene id: 1293592:LCU_RS04855
uniprot id: A0A8E2X8H0
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1293592:LCU RS02545
gene id: 1293592:LCU_RS02545
uniprot id: A0A8E2X8L6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1293592:LCU RS08490
gene id: 1293592:LCU_RS08490
uniprot id: A0A8E3BL89
names: Similarity
messages: Belongs to the peptidase C69 family.

1293592:LCU RS04850
gene id: 1293592:LCU_RS04850
uniprot id: A0A8E2X9X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1293592:LCU RS06135
gene id: 1293592:LCU_RS06135
uniprot id: A0A8E2X8X7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1293592:LCU RS05770
gene id: 1293592:LCU_RS05770
uniprot id: A0A8E2XBL4
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

1293592:LCU RS07985
gene id: 1293592:LCU_RS07985
uniprot id: A0A8E2X9J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1293592:LCU RS00255
gene id: 1293592:LCU_RS00255
uniprot id: A0A8E3BJW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS02720
gene id: 1293592:LCU_RS02720
uniprot id: A0A8E2XAQ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

1293592:LCU RS03500
gene id: 1293592:LCU_RS03500
uniprot id: A0A8E2X9G7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1293592:LCU RS05020
gene id: 1293592:LCU_RS05020
uniprot id: A0A8E2X8N3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1293592:LCU RS07530
gene id: 1293592:LCU_RS07530
uniprot id: A0A8E3BKN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

1293592:LCU RS07630
gene id: 1293592:LCU_RS07630
uniprot id: A0A8E3BL38
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1293592:LCU RS07010
gene id: 1293592:LCU_RS07010
uniprot id: A0A8E2X9S7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1293592:LCU RS06410
gene id: 1293592:LCU_RS06410
uniprot id: A0A8E3BLD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease M5 family.
messages: Cytoplasm
messages: Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.

1293592:LCU RS00905
gene id: 1293592:LCU_RS00905
uniprot id: A0A8E2X765
names: Similarity
messages: Belongs to the UPF0342 family.

1293592:LCU RS03615
gene id: 1293592:LCU_RS03615
uniprot id: A0A8E2X8J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

1293592:LCU RS09430
gene id: 1293592:LCU_RS09430
uniprot id: A0A8E2XA50
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

1293592:LCU RS08635
gene id: 1293592:LCU_RS08635
uniprot id: A0A8E2XAU8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

1293592:LCU RS02165
gene id: 1293592:LCU_RS02165
uniprot id: A0A8E2X8D0
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1293592:LCU RS09360
gene id: 1293592:LCU_RS09360
uniprot id: A0A8E2XA08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1293592:LCU RS01915
gene id: 1293592:LCU_RS01915
uniprot id: A0A8E2X8Z4
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1293592:LCU RS02080
gene id: 1293592:LCU_RS02080
uniprot id: A0A8E2X879
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

1293592:LCU RS02775
gene id: 1293592:LCU_RS02775
uniprot id: A0A8E2X7R3
names: Subcellular Location Annotation
messages: Cytoplasm

1293592:LCU RS03310
gene id: 1293592:LCU_RS03310
uniprot id: A0A8E3BKC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

1293592:LCU RS02120
gene id: 1293592:LCU_RS02120
uniprot id: A0A8E2X8G8
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1293592:LCU RS01725
gene id: 1293592:LCU_RS01725
uniprot id: A0A8E3BJS0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS06975
gene id: 1293592:LCU_RS06975
uniprot id: A0A8E2XA76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1293592:LCU RS05615
gene id: 1293592:LCU_RS05615
uniprot id: A0A8E2XBJ8
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1293592:LCU RS03175
gene id: 1293592:LCU_RS03175
uniprot id: A0A8E2X8I9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1293592:LCU RS06950
gene id: 1293592:LCU_RS06950
uniprot id: A0A8E2X980
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane

1293592:LCU RS03325
gene id: 1293592:LCU_RS03325
uniprot id: A0A8E3BKV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1293592:LCU RS08070
gene id: 1293592:LCU_RS08070
uniprot id: A0A8E2XA99
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS06965
gene id: 1293592:LCU_RS06965
uniprot id: A0A8E2X9G0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1293592:LCU RS01070
gene id: 1293592:LCU_RS01070
uniprot id: A0A8E2X7D5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

1293592:LCU RS09650
gene id: 1293592:LCU_RS09650
uniprot id: A0A8E2XAM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1293592:LCU RS01305
gene id: 1293592:LCU_RS01305
uniprot id: A0A8E2X7B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS04015
gene id: 1293592:LCU_RS04015
uniprot id: A0A8E2XAA0
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

1293592:LCU RS04320
gene id: 1293592:LCU_RS04320
uniprot id: A0A8E2X8J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1293592:LCU RS08160
gene id: 1293592:LCU_RS08160
uniprot id: A0A8E2X9Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1293592:LCU RS06180
gene id: 1293592:LCU_RS06180
uniprot id: A0A8E3BLC2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.

1293592:LCU RS01835
gene id: 1293592:LCU_RS01835
uniprot id: A0A8E2X891
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS01350
gene id: 1293592:LCU_RS01350
uniprot id: A0A8E3BKJ2
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

1293592:LCU RS04795
gene id: 1293592:LCU_RS04795
uniprot id: A0A8E2XBC0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1293592:LCU RS03760
gene id: 1293592:LCU_RS03760
uniprot id: A0A8E2X8C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacteriophage holin family. Cp-1 holin subfamily.
messages: Membrane

1293592:LCU RS08020
gene id: 1293592:LCU_RS08020
uniprot id: A0A8E2XA33
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS04945
gene id: 1293592:LCU_RS04945
uniprot id: A0A8E2X8I2
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1293592:LCU RS07025
gene id: 1293592:LCU_RS07025
uniprot id: A0A8E2X991
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1293592:LCU RS01165
gene id: 1293592:LCU_RS01165
uniprot id: A0A8E2XA77
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

1293592:LCU RS06555
gene id: 1293592:LCU_RS06555
uniprot id: A0A8E2X9L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1293592:LCU RS01565
gene id: 1293592:LCU_RS01565
uniprot id: A0A8E3BJR1
names: Similarity
messages: Belongs to the type IA topoisomerase family.

1293592:LCU RS01580
gene id: 1293592:LCU_RS01580
uniprot id: A0A8E3BK40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm

1293592:LCU RS06980
gene id: 1293592:LCU_RS06980
uniprot id: A0A8E2X9R3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1293592:LCU RS04955
gene id: 1293592:LCU_RS04955
uniprot id: A0A8E2XBD6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

1293592:LCU RS07955
gene id: 1293592:LCU_RS07955
uniprot id: A0A8E3BL60
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

1293592:LCU RS02220
gene id: 1293592:LCU_RS02220
uniprot id: A0A8E3BJ06
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS03170
gene id: 1293592:LCU_RS03170
uniprot id: A0A8E3BKU5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

1293592:LCU RS09035
gene id: 1293592:LCU_RS09035
uniprot id: A0A8E2XAF4
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1293592:LCU RS00600
gene id: 1293592:LCU_RS00600
uniprot id: A0A8E3BJY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1293592:LCU RS05965
gene id: 1293592:LCU_RS05965
uniprot id: A0A8E3BKU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1293592:LCU RS03630
gene id: 1293592:LCU_RS03630
uniprot id: A0A8E3BJ88
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

1293592:LCU RS06780
gene id: 1293592:LCU_RS06780
uniprot id: A0A8E2XAG5
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

1293592:LCU RS03195
gene id: 1293592:LCU_RS03195
uniprot id: A0A8E2X7W7
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.

1293592:LCU RS03640
gene id: 1293592:LCU_RS03640
uniprot id: A0A8E3BKX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

1293592:LCU RS04515
gene id: 1293592:LCU_RS04515
uniprot id: A0A8E3BL25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0291 family.
messages: Cytoplasm

1293592:LCU RS04520
gene id: 1293592:LCU_RS04520
uniprot id: A0A8E2X8Z6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

1293592:LCU RS05695
gene id: 1293592:LCU_RS05695
uniprot id: A0A8E2X9S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1293592:LCU RS04880
gene id: 1293592:LCU_RS04880
uniprot id: A0A8E2X9H2
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

1293592:LCU RS03655
gene id: 1293592:LCU_RS03655
uniprot id: A0A8E2X9I6
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

1293592:LCU RS03265
gene id: 1293592:LCU_RS03265
uniprot id: A0A8E2X7X0
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

1293592:LCU RS02570
gene id: 1293592:LCU_RS02570
uniprot id: A0A8E3BJ26
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

1293592:LCU RS07030
gene id: 1293592:LCU_RS07030
uniprot id: A0A8E2X9D1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1293592:LCU RS02755
gene id: 1293592:LCU_RS02755
uniprot id: A0A8E3BKS2
names: Function
names: Similarity
names: Subunit
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Homodimer and homohexamer; in equilibrium.
messages: Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.

1293592:LCU RS08235
gene id: 1293592:LCU_RS08235
uniprot id: A0A8E2XB00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS04280
gene id: 1293592:LCU_RS04280
uniprot id: A0A8E2X8W9
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1293592:LCU RS07070
gene id: 1293592:LCU_RS07070
uniprot id: A0A8E3BJT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1293592:LCU RS08295
gene id: 1293592:LCU_RS08295
uniprot id: A0A8E3BL78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm

1293592:LCU RS08730
gene id: 1293592:LCU_RS08730
uniprot id: A0A8E2X9W1
names: Similarity
messages: Belongs to the sigma-54 factor family.

1293592:LCU RS07100
gene id: 1293592:LCU_RS07100
uniprot id: A0A8E2X9A2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1293592:LCU RS05580
gene id: 1293592:LCU_RS05580
uniprot id: A0A8E2X9B8
names: Similarity
messages: Belongs to the polypeptide deformylase family.

1293592:LCU RS05010
gene id: 1293592:LCU_RS05010
uniprot id: A0A8E2X8J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

1293592:LCU RS03320
gene id: 1293592:LCU_RS03320
uniprot id: A0A8E3BKD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EzrA family.
messages: Cell membrane
messages: Membrane
messages: Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization.

1293592:LCU RS00855
gene id: 1293592:LCU_RS00855
uniprot id: A0A8E2X806
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1293592:LCU RS05970
gene id: 1293592:LCU_RS05970
uniprot id: A0A8E3BLB2
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1293592:LCU RS02925
gene id: 1293592:LCU_RS02925
uniprot id: A0A8E3BKB0
names: Similarity
messages: Belongs to the UPF0398 family.

1293592:LCU RS01310
gene id: 1293592:LCU_RS01310
uniprot id: A0A8E2X7L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS09220
gene id: 1293592:LCU_RS09220
uniprot id: A0A8E3BLI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS06540
gene id: 1293592:LCU_RS06540
uniprot id: A0A8E2XA79
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1293592:LCU RS00850
gene id: 1293592:LCU_RS00850
uniprot id: A0A8E2XA37
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

1293592:LCU RS01825
gene id: 1293592:LCU_RS01825
uniprot id: A0A8E3BKM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1293592:LCU RS05585
gene id: 1293592:LCU_RS05585
uniprot id: A0A8E2X9H8
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1293592:LCU RS09195
gene id: 1293592:LCU_RS09195
uniprot id: A0A8E2XB13
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS02225
gene id: 1293592:LCU_RS02225
uniprot id: A0A8E3BK75
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

1293592:LCU RS04420
gene id: 1293592:LCU_RS04420
uniprot id: A0A8E3BKK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1293592:LCU RS06960
gene id: 1293592:LCU_RS06960
uniprot id: A0A8E2X979
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1293592:LCU RS06760
gene id: 1293592:LCU_RS06760
uniprot id: A0A8E2XB98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

1293592:LCU RS02585
gene id: 1293592:LCU_RS02585
uniprot id: A0A8E2X8D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

1293592:LCU RS01700
gene id: 1293592:LCU_RS01700
uniprot id: A0A8E2X7F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

1293592:LCU RS09490
gene id: 1293592:LCU_RS09490
uniprot id: A0A8E2XAK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1293592:LCU RS03160
gene id: 1293592:LCU_RS03160
uniprot id: A0A8E3BJ59
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1293592:LCU RS09620
gene id: 1293592:LCU_RS09620
uniprot id: A0A8E2XAP6
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS04125
gene id: 1293592:LCU_RS04125
uniprot id: A0A8E2X8U8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1293592:LCU RS00450
gene id: 1293592:LCU_RS00450
uniprot id: A0A8E3BJX2
names: Similarity
messages: Belongs to the IMPACT family.

1293592:LCU RS04920
gene id: 1293592:LCU_RS04920
uniprot id: A0A8E2X941
names: Similarity
messages: Belongs to the ThiD family.

1293592:LCU RS05240
gene id: 1293592:LCU_RS05240
uniprot id: A0A8E2X983
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS02350
gene id: 1293592:LCU_RS02350
uniprot id: A0A8E2XAM6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

1293592:LCU RS07265
gene id: 1293592:LCU_RS07265
uniprot id: A0A8E2X9J3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

1293592:LCU RS09405
gene id: 1293592:LCU_RS09405
uniprot id: A0A8E3BLW8
names: Similarity
messages: Belongs to the LOG family.

1293592:LCU RS02055
gene id: 1293592:LCU_RS02055
uniprot id: A0A8E3BJT6
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS05045
gene id: 1293592:LCU_RS05045
uniprot id: A0A8E2X933
names: Similarity
messages: Belongs to the acylphosphatase family.

1293592:LCU RS06605
gene id: 1293592:LCU_RS06605
uniprot id: A0A8E2X939
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

1293592:LCU RS05540
gene id: 1293592:LCU_RS05540
uniprot id: A0A8E2XBI9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1293592:LCU RS03305
gene id: 1293592:LCU_RS03305
uniprot id: A0A8E3BJZ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1293592:LCU RS03190
gene id: 1293592:LCU_RS03190
uniprot id: A0A8E2X812
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1293592:LCU RS09700
gene id: 1293592:LCU_RS09700
uniprot id: A0A8E3BL14
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS06275
gene id: 1293592:LCU_RS06275
uniprot id: A0A8E2X8Z9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS01235
gene id: 1293592:LCU_RS01235
uniprot id: A0A8E2X7K4
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1293592:LCU RS03580
gene id: 1293592:LCU_RS03580
uniprot id: A0A8E2X9H6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1293592:LCU RS01985
gene id: 1293592:LCU_RS01985
uniprot id: A0A8E3BIZ2
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

1293592:LCU RS09365
gene id: 1293592:LCU_RS09365
uniprot id: A0A8E2XA85
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1293592:LCU RS07115
gene id: 1293592:LCU_RS07115
uniprot id: A0A8E2X9H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1293592:LCU RS06145
gene id: 1293592:LCU_RS06145
uniprot id: A0A8E2XBP2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.

1293592:LCU RS02250
gene id: 1293592:LCU_RS02250
uniprot id: A0A8E2X7K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS05890
gene id: 1293592:LCU_RS05890
uniprot id: A0A8E3BLA9
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

1293592:LCU RS09825
gene id: 1293592:LCU_RS09825
uniprot id: A0A8E2XB06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Cell envelope
messages: Releases the N-terminal proline from various substrates.

1293592:LCU RS01060
gene id: 1293592:LCU_RS01060
uniprot id: A0A8E2X8P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

1293592:LCU RS09705
gene id: 1293592:LCU_RS09705
uniprot id: A0A8E3BLG1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1293592:LCU RS00695
gene id: 1293592:LCU_RS00695
uniprot id: A0A8E2X7R5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1293592:LCU RS06225
gene id: 1293592:LCU_RS06225
uniprot id: A0A8E2X9Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1293592:LCU RS04695
gene id: 1293592:LCU_RS04695
uniprot id: A0A8E2X8E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

1293592:LCU RS01510
gene id: 1293592:LCU_RS01510
uniprot id: A0A8E2X815
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

1293592:LCU RS04935
gene id: 1293592:LCU_RS04935
uniprot id: A0A8E2X8H9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1293592:LCU RS00485
gene id: 1293592:LCU_RS00485
uniprot id: A0A8E2X719
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.

1293592:LCU RS05130
gene id: 1293592:LCU_RS05130
uniprot id: A0A8E3BKP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

1293592:LCU RS05185
gene id: 1293592:LCU_RS05185
uniprot id: A0A8E2X8V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1293592:LCU RS06385
gene id: 1293592:LCU_RS06385
uniprot id: A0A8E2X9I9
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

1293592:LCU RS07465
gene id: 1293592:LCU_RS07465
uniprot id: A0A8E3BLK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS00210
gene id: 1293592:LCU_RS00210
uniprot id: A0A8E2X736
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

1293592:LCU RS09240
gene id: 1293592:LCU_RS09240
uniprot id: A0A8E2XAF7
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS04995
gene id: 1293592:LCU_RS04995
uniprot id: A0A8E2X952
names: Subcellular Location Annotation
messages: Cell membrane

1293592:LCU RS03470
gene id: 1293592:LCU_RS03470
uniprot id: A0A8E3BJ79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. Ycf16 family.
messages: Membrane

1293592:LCU RS01805
gene id: 1293592:LCU_RS01805
uniprot id: A0A8E3BK46
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1293592:LCU RS02795
gene id: 1293592:LCU_RS02795
uniprot id: A0A8E2X808
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

1293592:LCU RS01940
gene id: 1293592:LCU_RS01940
uniprot id: A0A8E2XAF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UPF0213 family.
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1293592:LCU RS04475
gene id: 1293592:LCU_RS04475
uniprot id: A0A8E2XB87
names: Similarity
messages: Belongs to the UPF0213 family.

1293592:LCU RS06330
gene id: 1293592:LCU_RS06330
uniprot id: A0A8E3BLD3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1293592:LCU RS00595
gene id: 1293592:LCU_RS00595
uniprot id: A0A8E3BIR3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1293592:LCU RS05725
gene id: 1293592:LCU_RS05725
uniprot id: A0A8E3BL99
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS05335
gene id: 1293592:LCU_RS05335
uniprot id: A0A8E2X992
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS02990
gene id: 1293592:LCU_RS02990
uniprot id: A0A8E2X8B7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS04625
gene id: 1293592:LCU_RS04625
uniprot id: A0A8E2X8E3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1293592:LCU RS00975
gene id: 1293592:LCU_RS00975
uniprot id: A0A8E2X8N7
names: Similarity
messages: Belongs to the asparagine synthetase family.

1293592:LCU RS04115
gene id: 1293592:LCU_RS04115
uniprot id: A0A8E3BKI5
names: Similarity
messages: Belongs to the TPP enzyme family.

1293592:LCU RS01120
gene id: 1293592:LCU_RS01120
uniprot id: A0A8E3BKH7
names: Similarity
messages: Belongs to the GARS family.

1293592:LCU RS02200
gene id: 1293592:LCU_RS02200
uniprot id: A0A8E2X8H8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1293592:LCU RS09550
gene id: 1293592:LCU_RS09550
uniprot id: A0A8E3BLF1
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1293592:LCU RS01055
gene id: 1293592:LCU_RS01055
uniprot id: A0A8E2X7Z3
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

1293592:LCU RS07635
gene id: 1293592:LCU_RS07635
uniprot id: A0A8E3BJV2
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS09695
gene id: 1293592:LCU_RS09695
uniprot id: A0A8E2XAQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS04425
gene id: 1293592:LCU_RS04425
uniprot id: A0A8E3BJD5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1293592:LCU RS01905
gene id: 1293592:LCU_RS01905
uniprot id: A0A8E2X859
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1293592:LCU RS06640
gene id: 1293592:LCU_RS06640
uniprot id: A0A8E3BKI6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1293592:LCU RS08025
gene id: 1293592:LCU_RS08025
uniprot id: A0A8E3BKR6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

1293592:LCU RS01185
gene id: 1293592:LCU_RS01185
uniprot id: A0A8E3BK10
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1293592:LCU RS01810
gene id: 1293592:LCU_RS01810
uniprot id: A0A8E3BIY1
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1293592:LCU RS00560
gene id: 1293592:LCU_RS00560
uniprot id: A0A8E2X733
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

1293592:LCU RS02020
gene id: 1293592:LCU_RS02020
uniprot id: A0A8E2X7M7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1293592:LCU RS06490
gene id: 1293592:LCU_RS06490
uniprot id: A0A8E3BKX5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1293592:LCU RS04500
gene id: 1293592:LCU_RS04500
uniprot id: A0A8E3BKK5
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS04700
gene id: 1293592:LCU_RS04700
uniprot id: A0A8E2X8J3
names: Similarity
messages: Belongs to the GSP E family.

1293592:LCU RS09515
gene id: 1293592:LCU_RS09515
uniprot id: A0A8E2XA27
names: Similarity
messages: Belongs to the thioredoxin family.

1293592:LCU RS07090
gene id: 1293592:LCU_RS07090
uniprot id: A0A8E2X9Z2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1293592:LCU RS05445
gene id: 1293592:LCU_RS05445
uniprot id: A0A8E2X8P4
names: Similarity
messages: Belongs to the ClpA/ClpB family.

1293592:LCU RS06585
gene id: 1293592:LCU_RS06585
uniprot id: A0A8E3BLE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LPG synthase family.
messages: Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
messages: Cell membrane
messages: Membrane

1293592:LCU RS05435
gene id: 1293592:LCU_RS05435
uniprot id: A0A8E2X8P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HPr family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
messages: P-Ser-HPr interacts with the catabolite control protein A (CcpA), forming a complex that binds to DNA at the catabolite response elements cre, operator sites preceding a large number of catabolite-regulated genes. Thus, P-Ser-HPr is a corepressor in carbon catabolite repression (CCR), a mechanism that allows bacteria to coordinate and optimize the utilization of available carbon sources. P-Ser-HPr also plays a role in inducer exclusion, in which it probably interacts with several non-PTS permeases and inhibits their transport activity.

1293592:LCU RS01845
gene id: 1293592:LCU_RS01845
uniprot id: A0A8E2X7G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0298 family.
messages: Cytoplasm

1293592:LCU RS07855
gene id: 1293592:LCU_RS07855
uniprot id: A0A8E2XAH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS02085
gene id: 1293592:LCU_RS02085
uniprot id: A0A8E2X8C1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0756 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS06600
gene id: 1293592:LCU_RS06600
uniprot id: A0A8E2XAF0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1293592:LCU RS03285
gene id: 1293592:LCU_RS03285
uniprot id: A0A8E2XAW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1293592:LCU RS00220
gene id: 1293592:LCU_RS00220
uniprot id: A0A8E2X799
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS09470
gene id: 1293592:LCU_RS09470
uniprot id: A0A8E3BLE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. CshB subfamily.
messages: Cytoplasm
messages: Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures.

1293592:LCU RS05220
gene id: 1293592:LCU_RS05220
uniprot id: A0A8E3BJH9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1293592:LCU RS09505
gene id: 1293592:LCU_RS09505
uniprot id: A0A8E2XA31
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS06995
gene id: 1293592:LCU_RS06995
uniprot id: A0A8E3BJS6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1293592:LCU RS03585
gene id: 1293592:LCU_RS03585
uniprot id: A0A8E2X809
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1293592:LCU RS00870
gene id: 1293592:LCU_RS00870
uniprot id: A0A8E3BJZ2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1293592:LCU RS04300
gene id: 1293592:LCU_RS04300
uniprot id: A0A8E2X8E6
names: Similarity
messages: Belongs to the ribF family.

1293592:LCU RS04510
gene id: 1293592:LCU_RS04510
uniprot id: A0A8E3BKK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0154 family.
messages: Membrane

1293592:LCU RS02575
gene id: 1293592:LCU_RS02575
uniprot id: A0A8E3BK91
names: Similarity
messages: Belongs to the ThiD family.

1293592:LCU RS09095
gene id: 1293592:LCU_RS09095
uniprot id: A0A8E3BL32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS03035
gene id: 1293592:LCU_RS03035
uniprot id: A0A8E2X9B3
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

1293592:LCU RS00955
gene id: 1293592:LCU_RS00955
uniprot id: A0A8E3BK02
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

1293592:LCU RS03315
gene id: 1293592:LCU_RS03315
uniprot id: A0A8E3BJ69
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1293592:LCU RS08390
gene id: 1293592:LCU_RS08390
uniprot id: A0A8E3BL84
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

1293592:LCU RS06615
gene id: 1293592:LCU_RS06615
uniprot id: A0A8E2X938
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1293592:LCU RS09165
gene id: 1293592:LCU_RS09165
uniprot id: A0A8E2X9Z1
names: Similarity
messages: Belongs to the FGGY kinase family.

1293592:LCU RS02995
gene id: 1293592:LCU_RS02995
uniprot id: A0A8E3BJX9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

1293592:LCU RS06655
gene id: 1293592:LCU_RS06655
uniprot id: A0A8E3BJQ8
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

1293592:LCU RS04325
gene id: 1293592:LCU_RS04325
uniprot id: A0A8E2XB73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1293592:LCU RS04875
gene id: 1293592:LCU_RS04875
uniprot id: A0A8E2XBC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

1293592:LCU RS01290
gene id: 1293592:LCU_RS01290
uniprot id: A0A8E2X8S7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

1293592:LCU RS06635
gene id: 1293592:LCU_RS06635
uniprot id: A0A8E2X9M3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1293592:LCU RS01105
gene id: 1293592:LCU_RS01105
uniprot id: A0A8E3BK06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1293592:LCU RS09280
gene id: 1293592:LCU_RS09280
uniprot id: A0A8E2X9Z9
names: Similarity
messages: Belongs to the peptidase C1 family.

1293592:LCU RS02620
gene id: 1293592:LCU_RS02620
uniprot id: A0A8E2X7Y8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPase class C family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm

1293592:LCU RS01020
gene id: 1293592:LCU_RS01020
uniprot id: A0A8E3BJM7
names: Subcellular Location Annotation
messages: Cytoplasm

1293592:LCU RS05750
gene id: 1293592:LCU_RS05750
uniprot id: A0A8E2X8T4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1293592:LCU RS07015
gene id: 1293592:LCU_RS07015
uniprot id: A0A8E2X9Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1293592:LCU RS05125
gene id: 1293592:LCU_RS05125
uniprot id: A0A8E3BKA1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1293592:LCU RS09145
gene id: 1293592:LCU_RS09145
uniprot id: A0A8E3BLV3
names: Similarity
messages: Belongs to the XFP family.

1293592:LCU RS04690
gene id: 1293592:LCU_RS04690
uniprot id: A0A8E2X9V6
names: Function
messages: Required for transformation and DNA binding.

1293592:LCU RS01270
gene id: 1293592:LCU_RS01270
uniprot id: A0A8E3BK21
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1293592:LCU RS09415
gene id: 1293592:LCU_RS09415
uniprot id: A0A8E2XAS1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

1293592:LCU RS00180
gene id: 1293592:LCU_RS00180
uniprot id: A0A8E3BIN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS07000
gene id: 1293592:LCU_RS07000
uniprot id: A0A8E3BL05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1293592:LCU RS07670
gene id: 1293592:LCU_RS07670
uniprot id: A0A8E2X9G1
names: Similarity
messages: Belongs to the peptidase M13 family.

1293592:LCU RS09285
gene id: 1293592:LCU_RS09285
uniprot id: A0A8E2XA75
names: Similarity
messages: Belongs to the peptidase C1 family.

1293592:LCU RS00865
gene id: 1293592:LCU_RS00865
uniprot id: A0A8E3BJL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1293592:LCU RS01215
gene id: 1293592:LCU_RS01215
uniprot id: A0A8E2X8R9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1293592:LCU RS06775
gene id: 1293592:LCU_RS06775
uniprot id: A0A8E2X9V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

1293592:LCU RS05050
gene id: 1293592:LCU_RS05050
uniprot id: A0A8E3BK96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

1293592:LCU RS05680
gene id: 1293592:LCU_RS05680
uniprot id: A0A8E2X8S5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1293592:LCU RS01230
gene id: 1293592:LCU_RS01230
uniprot id: A0A8E2X7A4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

1293592:LCU RS09450
gene id: 1293592:LCU_RS09450
uniprot id: A0A8E2XCG6
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS07320
gene id: 1293592:LCU_RS07320
uniprot id: A0A8E2XAP7
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS07125
gene id: 1293592:LCU_RS07125
uniprot id: A0A8E2XA98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1293592:LCU RS02565
gene id: 1293592:LCU_RS02565
uniprot id: A0A8E3BK86
names: Similarity
messages: Belongs to the TPP enzyme family.

1293592:LCU RS06630
gene id: 1293592:LCU_RS06630
uniprot id: A0A8E2XA35
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1293592:LCU RS03410
gene id: 1293592:LCU_RS03410
uniprot id: A0A8E2X8L8
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

1293592:LCU RS09610
gene id: 1293592:LCU_RS09610
uniprot id: A0A8E2XB62
names: Function
messages: Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions.

1293592:LCU RS03220
gene id: 1293592:LCU_RS03220
uniprot id: A0A8E3BJZ4
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1293592:LCU RS06200
gene id: 1293592:LCU_RS06200
uniprot id: A0A8E2X8Y9
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

1293592:LCU RS09160
gene id: 1293592:LCU_RS09160
uniprot id: A0A8E2XB92
names: Similarity
messages: Belongs to the 6-phosphogluconate dehydrogenase family.

1293592:LCU RS02970
gene id: 1293592:LCU_RS02970
uniprot id: A0A8E2XAT7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. AddB/RexB type 2 subfamily.
messages: Heterodimer of AddA and RexB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity.

1293592:LCU RS00565
gene id: 1293592:LCU_RS00565
uniprot id: A0A8E2X7E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1293592:LCU RS09045
gene id: 1293592:LCU_RS09045
uniprot id: A0A8E3BLC3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1293592:LCU RS05330
gene id: 1293592:LCU_RS05330
uniprot id: A0A8E2XAS4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1293592:LCU RS06250
gene id: 1293592:LCU_RS06250
uniprot id: A0A8E3BKW2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1293592:LCU RS07935
gene id: 1293592:LCU_RS07935
uniprot id: A0A8E2XA21
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1293592:LCU RS03515
gene id: 1293592:LCU_RS03515
uniprot id: A0A8E2X807
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS09315
gene id: 1293592:LCU_RS09315
uniprot id: A0A8E3BK48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MrnC RNase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.

1293592:LCU RS02245
gene id: 1293592:LCU_RS02245
uniprot id: A0A8E2X935
names: Similarity
messages: Belongs to the UPF0346 family.

1293592:LCU RS00390
gene id: 1293592:LCU_RS00390
uniprot id: A0A8E2X8F9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS02045
gene id: 1293592:LCU_RS02045
uniprot id: A0A8E2X8F7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1293592:LCU RS03345
gene id: 1293592:LCU_RS03345
uniprot id: A0A8E2X7X9
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

1293592:LCU RS00985
gene id: 1293592:LCU_RS00985
uniprot id: A0A8E2X7C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

1293592:LCU RS07120
gene id: 1293592:LCU_RS07120
uniprot id: A0A8E2XBY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1293592:LCU RS00215
gene id: 1293592:LCU_RS00215
uniprot id: A0A8E2X6Y9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport.

1293592:LCU RS02930
gene id: 1293592:LCU_RS02930
uniprot id: A0A8E3BKT2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecU family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.

1293592:LCU RS03155
gene id: 1293592:LCU_RS03155
uniprot id: A0A8E3BKC1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1293592:LCU RS05990
gene id: 1293592:LCU_RS05990
uniprot id: A0A8E3BLZ5
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.
messages: Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.

1293592:LCU RS09555
gene id: 1293592:LCU_RS09555
uniprot id: A0A8E3BK61
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1293592:LCU RS01475
gene id: 1293592:LCU_RS01475
uniprot id: A0A8E2X887
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1293592:LCU RS02745
gene id: 1293592:LCU_RS02745
uniprot id: A0A8E3BJ35
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1293592:LCU RS01435
gene id: 1293592:LCU_RS01435
uniprot id: A0A8E2X805
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1293592:LCU RS08915
gene id: 1293592:LCU_RS08915
uniprot id: A0A8E2X9Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1293592:LCU RS01140
gene id: 1293592:LCU_RS01140
uniprot id: A0A8E2X8Q7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1293592:LCU RS05820
gene id: 1293592:LCU_RS05820
uniprot id: A0A8E2X9K7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1293592:LCU RS04265
gene id: 1293592:LCU_RS04265
uniprot id: A0A8E3BJC5
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS02040
gene id: 1293592:LCU_RS02040
uniprot id: A0A8E2XAG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1293592:LCU RS09380
gene id: 1293592:LCU_RS09380
uniprot id: A0A8E2XAL9
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS08625
gene id: 1293592:LCU_RS08625
uniprot id: A0A8E2X9Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. EmrB family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS04120
gene id: 1293592:LCU_RS04120
uniprot id: A0A8E3BL02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

1293592:LCU RS09480
gene id: 1293592:LCU_RS09480
uniprot id: A0A8E3BLD9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1293592:LCU RS04095
gene id: 1293592:LCU_RS04095
uniprot id: A0A8E3BK45
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS06610
gene id: 1293592:LCU_RS06610
uniprot id: A0A8E2X976
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

1293592:LCU RS05225
gene id: 1293592:LCU_RS05225
uniprot id: A0A8E3BKQ2
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS00275
gene id: 1293592:LCU_RS00275
uniprot id: A0A8E2X8E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LPG synthase family.
messages: Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
messages: Cell membrane
messages: Membrane

1293592:LCU RS05120
gene id: 1293592:LCU_RS05120
uniprot id: A0A8E2X944
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1293592:LCU RS00925
gene id: 1293592:LCU_RS00925
uniprot id: A0A8E2XA47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PrsA family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.

1293592:LCU RS09270
gene id: 1293592:LCU_RS09270
uniprot id: A0A8E2XA03
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

1293592:LCU RS09780
gene id: 1293592:LCU_RS09780
uniprot id: A0A8E2XBB4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1293592:LCU RS05205
gene id: 1293592:LCU_RS05205
uniprot id: A0A8E3BKA5
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS01540
gene id: 1293592:LCU_RS01540
uniprot id: A0A8E2X7E1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1293592:LCU RS01920
gene id: 1293592:LCU_RS01920
uniprot id: A0A8E2X7H4
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1293592:LCU RS04530
gene id: 1293592:LCU_RS04530
uniprot id: A0A8E2X9T9
names: Similarity
messages: Belongs to the RecJ family.

1293592:LCU RS06525
gene id: 1293592:LCU_RS06525
uniprot id: A0A8E2X966
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YabA family.
messages: Interacts with both DnaA and DnaN, acting as a bridge between these two proteins.
messages: Involved in initiation control of chromosome replication.

1293592:LCU RS02535
gene id: 1293592:LCU_RS02535
uniprot id: A0A8E2X7Y0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1293592:LCU RS07045
gene id: 1293592:LCU_RS07045
uniprot id: A0A8E2XBX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1293592:LCU RS02750
gene id: 1293592:LCU_RS02750
uniprot id: A0A8E3BKA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1293592:LCU RS03450
gene id: 1293592:LCU_RS03450
uniprot id: A0A8E2X8Y1
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1293592:LCU RS02980
gene id: 1293592:LCU_RS02980
uniprot id: A0A8E2X8R7
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

1293592:LCU RS05675
gene id: 1293592:LCU_RS05675
uniprot id: A0A8E2X8W6
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS04210
gene id: 1293592:LCU_RS04210
uniprot id: A0A8E2X8V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRP transporter (TC 2.A.7.5) family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS01505
gene id: 1293592:LCU_RS01505
uniprot id: A0A8E3BKK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsQ/DivIB family. DivIB subfamily.
messages: Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex.
messages: Cell membrane

1293592:LCU RS06855
gene id: 1293592:LCU_RS06855
uniprot id: A0A8E3BLG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

1293592:LCU RS01315
gene id: 1293592:LCU_RS01315
uniprot id: A0A8E2XA96
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1293592:LCU RS06025
gene id: 1293592:LCU_RS06025
uniprot id: A0A8E2X9E6
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS02205
gene id: 1293592:LCU_RS02205
uniprot id: A0A8E2X830
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

1293592:LCU RS00200
gene id: 1293592:LCU_RS00200
uniprot id: A0A8E2X8E2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS01005
gene id: 1293592:LCU_RS01005
uniprot id: A0A8E2X823
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S15 family.
messages: Homodimer.
messages: Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.

1293592:LCU RS09445
gene id: 1293592:LCU_RS09445
uniprot id: A0A8E3BLH0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1293592:LCU RS03300
gene id: 1293592:LCU_RS03300
uniprot id: A0A8E2X8F5
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

1293592:LCU RS06590
gene id: 1293592:LCU_RS06590
uniprot id: A0A8E2X9M8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1293592:LCU RS09290
gene id: 1293592:LCU_RS09290
uniprot id: A0A8E2XCF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

1293592:LCU RS05620
gene id: 1293592:LCU_RS05620
uniprot id: A0A8E2X9R4
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS07065
gene id: 1293592:LCU_RS07065
uniprot id: A0A8E3BL08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1293592:LCU RS05815
gene id: 1293592:LCU_RS05815
uniprot id: A0A8E2X9E5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

1293592:LCU RS06405
gene id: 1293592:LCU_RS06405
uniprot id: A0A8E3BKX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1293592:LCU RS07980
gene id: 1293592:LCU_RS07980
uniprot id: A0A8E2XAX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1293592:LCU RS02905
gene id: 1293592:LCU_RS02905
uniprot id: A0A8E3BJX7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1293592:LCU RS08555
gene id: 1293592:LCU_RS08555
uniprot id: A0A8E2XC93
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS06080
gene id: 1293592:LCU_RS06080
uniprot id: A0A8E2XAA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS02630
gene id: 1293592:LCU_RS02630
uniprot id: A0A8E2X8M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1293592:LCU RS02965
gene id: 1293592:LCU_RS02965
uniprot id: A0A8E2X826
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. AddA subfamily.
messages: Heterodimer of AddA and AddB/RexB.
messages: The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.

1293592:LCU RS07625
gene id: 1293592:LCU_RS07625
uniprot id: A0A8E3BKP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

1293592:LCU RS01330
gene id: 1293592:LCU_RS01330
uniprot id: A0A8E3BJP7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1293592:LCU RS06845
gene id: 1293592:LCU_RS06845
uniprot id: A0A8E3BJR8
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.

1293592:LCU RS03510
gene id: 1293592:LCU_RS03510
uniprot id: A0A8E2X853
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

1293592:LCU RS01485
gene id: 1293592:LCU_RS01485
uniprot id: A0A8E3BJQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS00570
gene id: 1293592:LCU_RS00570
uniprot id: A0A8E2XA09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1293592:LCU RS07050
gene id: 1293592:LCU_RS07050
uniprot id: A0A8E2XA87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1293592:LCU RS02580
gene id: 1293592:LCU_RS02580
uniprot id: A0A8E3BKR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

1293592:LCU RS01175
gene id: 1293592:LCU_RS01175
uniprot id: A0A8E2X7P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1293592:LCU RS03625
gene id: 1293592:LCU_RS03625
uniprot id: A0A8E3BKE7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1293592:LCU RS05500
gene id: 1293592:LCU_RS05500
uniprot id: A0A8E3BL85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

1293592:LCU RS08425
gene id: 1293592:LCU_RS08425
uniprot id: A0A8E2XAD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS03150
gene id: 1293592:LCU_RS03150
uniprot id: A0A8E3BJY9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1293592:LCU RS01190
gene id: 1293592:LCU_RS01190
uniprot id: A0A8E3BIU3
names: Similarity
messages: Belongs to the TlyA family.

1293592:LCU RS02550
gene id: 1293592:LCU_RS02550
uniprot id: A0A8E2X871
names: Similarity
messages: Belongs to the peptidase T1B family. HslV subfamily.

1293592:LCU RS08150
gene id: 1293592:LCU_RS08150
uniprot id: A0A8E2XAZ0
names: Function
names: Similarity
messages: Belongs to the transposase IS30 family.
messages: Required for the transposition of the insertion element.

1293592:LCU RS08950
gene id: 1293592:LCU_RS08950
uniprot id: A0A8E3BKX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1293592:LCU RS04985
gene id: 1293592:LCU_RS04985
uniprot id: A0A8E3BKN8
names: Similarity
messages: Belongs to the HesB/IscA family.

1293592:LCU RS05760
gene id: 1293592:LCU_RS05760
uniprot id: A0A8E2X8T3
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1293592:LCU RS05365
gene id: 1293592:LCU_RS05365
uniprot id: A0A8E2X8X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArsC family. Spx subfamily.
messages: Cytoplasm
messages: Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes. Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP). This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.
messages: Interacts with the C-terminal domain of the alpha subunit of the RNAP.

1293592:LCU RS06925
gene id: 1293592:LCU_RS06925
uniprot id: A0A8E3BL00
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1293592:LCU RS04770
gene id: 1293592:LCU_RS04770
uniprot id: A0A8E2X9W5
names: Similarity
messages: Belongs to the glutamine synthetase family.

1293592:LCU RS07990
gene id: 1293592:LCU_RS07990
uniprot id: A0A8E2X9P2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1293592:LCU RS07800
gene id: 1293592:LCU_RS07800
uniprot id: A0A8E3BL51
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1293592:LCU RS00355
gene id: 1293592:LCU_RS00355
uniprot id: A0A8E3BJI6
names: Similarity
messages: Belongs to the cycloisomerase 2 family.

1293592:LCU RS07835
gene id: 1293592:LCU_RS07835
uniprot id: A0A8E2X9H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family.
messages: Membrane

1293592:LCU RS03290
gene id: 1293592:LCU_RS03290
uniprot id: A0A8E2X8W0
names: Similarity
messages: Belongs to the UPF0758 family.

1293592:LCU RS07710
gene id: 1293592:LCU_RS07710
uniprot id: A0A8E2XBB4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1293592:LCU RS03060
gene id: 1293592:LCU_RS03060
uniprot id: A0A8E2XAU5
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1293592:LCU RS05410
gene id: 1293592:LCU_RS05410
uniprot id: A0A8E3BL80
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

1293592:LCU RS05470
gene id: 1293592:LCU_RS05470
uniprot id: A0A8E2X985
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family.
messages: Membrane

1293592:LCU RS08895
gene id: 1293592:LCU_RS08895
uniprot id: A0A8E2XAD1
names: Similarity
messages: Belongs to the universal stress protein A family.

1293592:LCU RS03460
gene id: 1293592:LCU_RS03460
uniprot id: A0A8E3BK08
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

1293592:LCU RS04665
gene id: 1293592:LCU_RS04665
uniprot id: A0A8E3BJE7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mg(2+). Can also accept Mn(2+).

1293592:LCU RS02805
gene id: 1293592:LCU_RS02805
uniprot id: A0A8E2X8P8
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Tetramer of two alpha and two beta subunits.

1293592:LCU RS07260
gene id: 1293592:LCU_RS07260
uniprot id: A0A8E2X9A9
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1293592:LCU RS03690
gene id: 1293592:LCU_RS03690
uniprot id: A0A8E2X8K6
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS01370
gene id: 1293592:LCU_RS01370
uniprot id: A0A8E2X7B5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

1293592:LCU RS02705
gene id: 1293592:LCU_RS02705
uniprot id: A0A8E2X7V5
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

1293592:LCU RS01615
gene id: 1293592:LCU_RS01615
uniprot id: A0A8E2X7F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. EmrB family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS03610
gene id: 1293592:LCU_RS03610
uniprot id: A0A8E2X902
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

1293592:LCU RS05995
gene id: 1293592:LCU_RS05995
uniprot id: A0A8E2X8W5
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS04455
gene id: 1293592:LCU_RS04455
uniprot id: A0A8E2X8B6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS00375
gene id: 1293592:LCU_RS00375
uniprot id: A0A8E3BKC7
names: Function
names: Similarity
messages: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

1293592:LCU RS02110
gene id: 1293592:LCU_RS02110
uniprot id: A0A8E2X7T6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpA family.
messages: Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Cytoplasm
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.

1293592:LCU RS03620
gene id: 1293592:LCU_RS03620
uniprot id: A0A8E3BK17
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1293592:LCU RS00885
gene id: 1293592:LCU_RS00885
uniprot id: A0A8E3BKG4
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1293592:LCU RS03210
gene id: 1293592:LCU_RS03210
uniprot id: A0A8E2X8U9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

1293592:LCU RS08065
gene id: 1293592:LCU_RS08065
uniprot id: A0A8E2XA34
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1293592:LCU RS04930
gene id: 1293592:LCU_RS04930
uniprot id: A0A8E2X9Y0
names: Similarity
messages: Belongs to the UPF0340 family.

1293592:LCU RS01470
gene id: 1293592:LCU_RS01470
uniprot id: A0A8E2XAB6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1293592:LCU RS03165
gene id: 1293592:LCU_RS03165
uniprot id: A0A8E3BKC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1293592:LCU RS09120
gene id: 1293592:LCU_RS09120
uniprot id: A0A8E2XAG1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS03555
gene id: 1293592:LCU_RS03555
uniprot id: A0A8E3BJ83
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS05300
gene id: 1293592:LCU_RS05300
uniprot id: A0A8E2X962
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS01180
gene id: 1293592:LCU_RS01180
uniprot id: A0A8E3BJN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1293592:LCU RS02880
gene id: 1293592:LCU_RS02880
uniprot id: A0A8E2XAS8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1293592:LCU RS08430
gene id: 1293592:LCU_RS08430
uniprot id: A0A8E2XB19
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

1293592:LCU RS02100
gene id: 1293592:LCU_RS02100
uniprot id: A0A8E2X7N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1293592:LCU RS05530
gene id: 1293592:LCU_RS05530
uniprot id: A0A8E2X8Q4
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

1293592:LCU RS01535
gene id: 1293592:LCU_RS01535
uniprot id: A0A8E2X7H8
names: Subcellular Location Annotation
messages: Cytoplasm

1293592:LCU RS07075
gene id: 1293592:LCU_RS07075
uniprot id: A0A8E3BL10
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1293592:LCU RS09535
gene id: 1293592:LCU_RS09535
uniprot id: A0A8E2XB53
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-DCP.
messages: Belongs to the DltC family.
messages: Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
messages: Cytoplasm

1293592:LCU RS03140
gene id: 1293592:LCU_RS03140
uniprot id: A0A8E2X8T8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1293592:LCU RS09495
gene id: 1293592:LCU_RS09495
uniprot id: A0A8E2XAT2
names: Similarity
messages: Belongs to the UPF0473 family.

1293592:LCU RS07135
gene id: 1293592:LCU_RS07135
uniprot id: A0A8E3BKL6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1293592:LCU RS05280
gene id: 1293592:LCU_RS05280
uniprot id: A0A8E2X8W3
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS07415
gene id: 1293592:LCU_RS07415
uniprot id: A0A8E2X9H3
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS06595
gene id: 1293592:LCU_RS06595
uniprot id: A0A8E2X9U0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1293592:LCU RS02760
gene id: 1293592:LCU_RS02760
uniprot id: A0A8E2X8E4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1293592:LCU RS06985
gene id: 1293592:LCU_RS06985
uniprot id: A0A8E3BKK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1293592:LCU RS05165
gene id: 1293592:LCU_RS05165
uniprot id: A0A8E2XA07
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1293592:LCU RS02590
gene id: 1293592:LCU_RS02590
uniprot id: A0A8E2X8H5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

1293592:LCU RS03105
gene id: 1293592:LCU_RS03105
uniprot id: A0A8E2X8N0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

1293592:LCU RS01745
gene id: 1293592:LCU_RS01745
uniprot id: A0A8E3BKL7
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

1293592:LCU RS08745
gene id: 1293592:LCU_RS08745
uniprot id: A0A8E2XCB1
names: Subcellular Location Annotation
messages: Cytoplasm

1293592:LCU RS05295
gene id: 1293592:LCU_RS05295
uniprot id: A0A8E2X9M4
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS03590
gene id: 1293592:LCU_RS03590
uniprot id: A0A8E2X863
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1293592:LCU RS04865
gene id: 1293592:LCU_RS04865
uniprot id: A0A8E2X8H4
names: Similarity
messages: Belongs to the EamA transporter family.

1293592:LCU RS06560
gene id: 1293592:LCU_RS06560
uniprot id: A0A8E3BKI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1293592:LCU RS09815
gene id: 1293592:LCU_RS09815
uniprot id: A0A8E2XC74
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1293592:LCU RS04460
gene id: 1293592:LCU_RS04460
uniprot id: A0A8E2X8G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1293592:LCU RS06695
gene id: 1293592:LCU_RS06695
uniprot id: A0A8E2X948
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS01375
gene id: 1293592:LCU_RS01375
uniprot id: A0A8E2X7G6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1293592:LCU RS07060
gene id: 1293592:LCU_RS07060
uniprot id: A0A8E3BKL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1293592:LCU RS01780
gene id: 1293592:LCU_RS01780
uniprot id: A0A8E2X7Q5
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS06380
gene id: 1293592:LCU_RS06380
uniprot id: A0A8E2XA04
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

1293592:LCU RS01090
gene id: 1293592:LCU_RS01090
uniprot id: A0A8E2X831
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1293592:LCU RS02070
gene id: 1293592:LCU_RS02070
uniprot id: A0A8E3BK67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Cytoplasm
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.

1293592:LCU RS07485
gene id: 1293592:LCU_RS07485
uniprot id: A0A8E2X9E2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1293592:LCU RS00580
gene id: 1293592:LCU_RS00580
uniprot id: A0A8E2X7I6
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1293592:LCU RS08000
gene id: 1293592:LCU_RS08000
uniprot id: A0A8E2XAY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
messages: Cell membrane
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.

1293592:LCU RS09675
gene id: 1293592:LCU_RS09675
uniprot id: A0A8E2XA48
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1293592:LCU RS01895
gene id: 1293592:LCU_RS01895
uniprot id: A0A8E3BK59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

1293592:LCU RS04810
gene id: 1293592:LCU_RS04810
uniprot id: A0A8E2X901
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1293592:LCU RS08605
gene id: 1293592:LCU_RS08605
uniprot id: A0A8E2XB35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

1293592:LCU RS07805
gene id: 1293592:LCU_RS07805
uniprot id: A0A8E3BLM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS05495
gene id: 1293592:LCU_RS05495
uniprot id: A0A8E3BK77
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

1293592:LCU RS00635
gene id: 1293592:LCU_RS00635
uniprot id: A0A8E2X745
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1293592:LCU RS06210
gene id: 1293592:LCU_RS06210
uniprot id: A0A8E2X8Y8
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1293592:LCU RS03115
gene id: 1293592:LCU_RS03115
uniprot id: A0A8E2X7V0
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Homohexamer.

1293592:LCU RS07645
gene id: 1293592:LCU_RS07645
uniprot id: A0A8E3BLL1
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS07085
gene id: 1293592:LCU_RS07085
uniprot id: A0A8E2X9T6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1293592:LCU RS00295
gene id: 1293592:LCU_RS00295
uniprot id: A0A8E2X7B1
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

1293592:LCU RS06515
gene id: 1293592:LCU_RS06515
uniprot id: A0A8E2XAE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-ACP thioesterase family.
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: chloroplast

1293592:LCU RS06420
gene id: 1293592:LCU_RS06420
uniprot id: A0A8E2X9S6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS07650
gene id: 1293592:LCU_RS07650
uniprot id: A0A8E2X9Y7
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

1293592:LCU RS03715
gene id: 1293592:LCU_RS03715
uniprot id: A0A8E3BJ93
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

1293592:LCU RS08750
gene id: 1293592:LCU_RS08750
uniprot id: A0A8E2XAV8
names: Subcellular Location Annotation
messages: Cytoplasm

1293592:LCU RS01765
gene id: 1293592:LCU_RS01765
uniprot id: A0A8E2X7F6
names: Function
names: Similarity
names: Subunit
messages: A non-essential component of RNA polymerase (RNAP).
messages: Belongs to the RNA polymerase subunit epsilon family.
messages: RNAP is composed of a core of 2 alpha, a beta and a beta' subunit. The core is associated with a delta subunit, and at least one of epsilon or omega. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1293592:LCU RS07020
gene id: 1293592:LCU_RS07020
uniprot id: A0A8E2XAM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1293592:LCU RS08075
gene id: 1293592:LCU_RS08075
uniprot id: A0A8E2XAY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS01240
gene id: 1293592:LCU_RS01240
uniprot id: A0A8E2XA86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

1293592:LCU RS03670
gene id: 1293592:LCU_RS03670
uniprot id: A0A8E2X828
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS05135
gene id: 1293592:LCU_RS05135
uniprot id: A0A8E2XB88
names: Similarity
names: Subunit
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
messages: Homotetramer.

1293592:LCU RS05670
gene id: 1293592:LCU_RS05670
uniprot id: A0A8E2X8S3
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

1293592:LCU RS01065
gene id: 1293592:LCU_RS01065
uniprot id: A0A8E2X780
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1293592:LCU RS05830
gene id: 1293592:LCU_RS05830
uniprot id: A0A8E2X8U4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1293592:LCU RS05825
gene id: 1293592:LCU_RS05825
uniprot id: A0A8E2XA78
names: Similarity
messages: Belongs to the diacylglycerol/lipid kinase family.

1293592:LCU RS05025
gene id: 1293592:LCU_RS05025
uniprot id: A0A8E2X8J1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1293592:LCU RS06480
gene id: 1293592:LCU_RS06480
uniprot id: A0A8E3BKX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

1293592:LCU RS04305
gene id: 1293592:LCU_RS04305
uniprot id: A0A8E2X8A3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1293592:LCU RS03680
gene id: 1293592:LCU_RS03680
uniprot id: A0A8E2XB09
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

1293592:LCU RS07705
gene id: 1293592:LCU_RS07705
uniprot id: A0A8E3BKP7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1293592:LCU RS06175
gene id: 1293592:LCU_RS06175
uniprot id: A0A8E3BKV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1293592:LCU RS05275
gene id: 1293592:LCU_RS05275
uniprot id: A0A8E2X8M1
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1293592:LCU RS07055
gene id: 1293592:LCU_RS07055
uniprot id: A0A8E2X9S3
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1293592:LCU RS08215
gene id: 1293592:LCU_RS08215
uniprot id: A0A8E3BL74
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

1293592:LCU RS04160
gene id: 1293592:LCU_RS04160
uniprot id: A0A8E2X8H1
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS03080
gene id: 1293592:LCU_RS03080
uniprot id: A0A8E3BKB5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS03040
gene id: 1293592:LCU_RS03040
uniprot id: A0A8E2X7U0
names: Similarity
messages: Belongs to the peptidase C69 family.

1293592:LCU RS03575
gene id: 1293592:LCU_RS03575
uniprot id: A0A8E2X8T2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1293592:LCU RS02715
gene id: 1293592:LCU_RS02715
uniprot id: A0A8E2X7Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

1293592:LCU RS09005
gene id: 1293592:LCU_RS09005
uniprot id: A0A8E2XA05
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS05715
gene id: 1293592:LCU_RS05715
uniprot id: A0A8E3BJK6
names: Similarity
messages: Belongs to the peptidase M29 family.

1293592:LCU RS09635
gene id: 1293592:LCU_RS09635
uniprot id: A0A8E3BK65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. EmrB family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS07095
gene id: 1293592:LCU_RS07095
uniprot id: A0A8E2XAM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1293592:LCU RS04440
gene id: 1293592:LCU_RS04440
uniprot id: A0A8E2X8Y5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1293592:LCU RS06935
gene id: 1293592:LCU_RS06935
uniprot id: A0A8E2X9R5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS05945
gene id: 1293592:LCU_RS05945
uniprot id: A0A8E2X9D6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SprT family.
messages: Binds 1 zinc ion.
messages: Cytoplasm

1293592:LCU RS08050
gene id: 1293592:LCU_RS08050
uniprot id: A0A8E3BJX5
names: Similarity
messages: Belongs to the EamA transporter family.

1293592:LCU RS00745
gene id: 1293592:LCU_RS00745
uniprot id: A0A8E2XA28
names: Similarity
messages: Belongs to the GST superfamily.

1293592:LCU RS04835
gene id: 1293592:LCU_RS04835
uniprot id: A0A8E3BL43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS04970
gene id: 1293592:LCU_RS04970
uniprot id: A0A8E3BK92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS09540
gene id: 1293592:LCU_RS09540
uniprot id: A0A8E2XAN7
names: Similarity
messages: Belongs to the DltD family.

1293592:LCU RS00615
gene id: 1293592:LCU_RS00615
uniprot id: A0A8E2X7U9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

1293592:LCU RS06880
gene id: 1293592:LCU_RS06880
uniprot id: A0A8E2X9A4
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

1293592:LCU RS06670
gene id: 1293592:LCU_RS06670
uniprot id: A0A8E2X9V0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1293592:LCU RS03570
gene id: 1293592:LCU_RS03570
uniprot id: A0A8E2X8N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1293592:LCU RS07725
gene id: 1293592:LCU_RS07725
uniprot id: A0A8E3BLL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1293592:LCU RS00530
gene id: 1293592:LCU_RS00530
uniprot id: A0A8E3BKD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1293592:LCU RS01620
gene id: 1293592:LCU_RS01620
uniprot id: A0A8E2X7N8
names: Similarity
messages: Belongs to the TelA family.

1293592:LCU RS04505
gene id: 1293592:LCU_RS04505
uniprot id: A0A8E3BJD9
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS04820
gene id: 1293592:LCU_RS04820
uniprot id: A0A8E3BKM5
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS07995
gene id: 1293592:LCU_RS07995
uniprot id: A0A8E2X9J7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

1293592:LCU RS01365
gene id: 1293592:LCU_RS01365
uniprot id: A0A8E2X8T6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

1293592:LCU RS07515
gene id: 1293592:LCU_RS07515
uniprot id: A0A8E2XC10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS00400
gene id: 1293592:LCU_RS00400
uniprot id: A0A8E2X755
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

1293592:LCU RS02740
gene id: 1293592:LCU_RS02740
uniprot id: A0A8E3BK94
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

1293592:LCU RS05730
gene id: 1293592:LCU_RS05730
uniprot id: A0A8E2X9D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS01495
gene id: 1293592:LCU_RS01495
uniprot id: A0A8E3BIW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1293592:LCU RS02125
gene id: 1293592:LCU_RS02125
uniprot id: A0A8E2X820
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.
messages: Cell membrane
messages: Membrane
messages: Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.

1293592:LCU RS09440
gene id: 1293592:LCU_RS09440
uniprot id: A0A8E2XA94
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

1293592:LCU RS05190
gene id: 1293592:LCU_RS05190
uniprot id: A0A8E2XBG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

1293592:LCU RS01160
gene id: 1293592:LCU_RS01160
uniprot id: A0A8E2X7J4
names: Similarity
messages: Belongs to the asp23 family.

1293592:LCU RS01085
gene id: 1293592:LCU_RS01085
uniprot id: A0A8E2XA67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1293592:LCU RS04345
gene id: 1293592:LCU_RS04345
uniprot id: A0A8E3BKJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1293592:LCU RS01775
gene id: 1293592:LCU_RS01775
uniprot id: A0A8E2X7G3
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS06280
gene id: 1293592:LCU_RS06280
uniprot id: A0A8E2X937
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

1293592:LCU RS03065
gene id: 1293592:LCU_RS03065
uniprot id: A0A8E2X8S8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1293592:LCU RS09125
gene id: 1293592:LCU_RS09125
uniprot id: A0A8E3BKY2
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

1293592:LCU RS08265
gene id: 1293592:LCU_RS08265
uniprot id: A0A8E2XC74
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1293592:LCU RS01115
gene id: 1293592:LCU_RS01115
uniprot id: A0A8E3BK11
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1293592:LCU RS03110
gene id: 1293592:LCU_RS03110
uniprot id: A0A8E2X9C3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides.
messages: Cytoplasm

1293592:LCU RS07970
gene id: 1293592:LCU_RS07970
uniprot id: A0A8E2XA25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1293592:LCU RS09190
gene id: 1293592:LCU_RS09190
uniprot id: A0A8E2XCE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

1293592:LCU RS04105
gene id: 1293592:LCU_RS04105
uniprot id: A0A8E3BJB5
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS03340
gene id: 1293592:LCU_RS03340
uniprot id: A0A8E2X9E7
names: Function
names: Similarity
names: Subunit
messages: In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily.
messages: Monomer.
messages: Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine.

1293592:LCU RS02160
gene id: 1293592:LCU_RS02160
uniprot id: A0A8E2X889
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1293592:LCU RS09105
gene id: 1293592:LCU_RS09105
uniprot id: A0A8E2XCE2
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

1293592:LCU RS01155
gene id: 1293592:LCU_RS01155
uniprot id: A0A8E2X795
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1293592:LCU RS04045
gene id: 1293592:LCU_RS04045
uniprot id: A0A8E2X8Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

1293592:LCU RS08060
gene id: 1293592:LCU_RS08060
uniprot id: A0A8E3BLN7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1293592:LCU RS06140
gene id: 1293592:LCU_RS06140
uniprot id: A0A8E2X959
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm
messages: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.

1293592:LCU RS07005
gene id: 1293592:LCU_RS07005
uniprot id: A0A8E3BLH3
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1293592:LCU RS04340
gene id: 1293592:LCU_RS04340
uniprot id: A0A8E3BK60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1293592:LCU RS06890
gene id: 1293592:LCU_RS06890
uniprot id: A0A8E2X9F3
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS09560
gene id: 1293592:LCU_RS09560
uniprot id: A0A8E2XAR9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1293592:LCU RS01080
gene id: 1293592:LCU_RS01080
uniprot id: A0A8E2X7I7
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1293592:LCU RS06955
gene id: 1293592:LCU_RS06955
uniprot id: A0A8E2X9C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

1293592:LCU RS04450
gene id: 1293592:LCU_RS04450
uniprot id: A0A8E2X9T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1293592:LCU RS08515
gene id: 1293592:LCU_RS08515
uniprot id: A0A8E2XA83
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS00740
gene id: 1293592:LCU_RS00740
uniprot id: A0A8E2X7G0
names: Similarity
messages: Belongs to the OsmC/Ohr family.

1293592:LCU RS05140
gene id: 1293592:LCU_RS05140
uniprot id: A0A8E3BJH4
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS08610
gene id: 1293592:LCU_RS08610
uniprot id: A0A8E2X9S0
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1293592:LCU RS00470
gene id: 1293592:LCU_RS00470
uniprot id: A0A8E2X8G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1293592:LCU RS01225
gene id: 1293592:LCU_RS01225
uniprot id: A0A8E2X7E9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS01670
gene id: 1293592:LCU_RS01670
uniprot id: A0A8E3BKL2
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS02765
gene id: 1293592:LCU_RS02765
uniprot id: A0A8E2X8J4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1293592:LCU RS03135
gene id: 1293592:LCU_RS03135
uniprot id: A0A8E2XAV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1293592:LCU RS08780
gene id: 1293592:LCU_RS08780
uniprot id: A0A8E3BK14
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1293592:LCU RS08600
gene id: 1293592:LCU_RS08600
uniprot id: A0A8E2XAE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRP transporter (TC 2.A.7.5) family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS03635
gene id: 1293592:LCU_RS03635
uniprot id: A0A8E3BKF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

1293592:LCU RS02615
gene id: 1293592:LCU_RS02615
uniprot id: A0A8E2X7Q1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1293592:LCU RS00170
gene id: 1293592:LCU_RS00170
uniprot id: A0A8E3BJU8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1293592:LCU RS07355
gene id: 1293592:LCU_RS07355
uniprot id: A0A8E2X9V4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1293592:LCU RS09055
gene id: 1293592:LCU_RS09055
uniprot id: A0A8E3BLB9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1293592:LCU RS06730
gene id: 1293592:LCU_RS06730
uniprot id: A0A8E3BKJ1
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1293592:LCU RS08350
gene id: 1293592:LCU_RS08350
uniprot id: A0A8E2X9W6
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1293592:LCU RS09390
gene id: 1293592:LCU_RS09390
uniprot id: A0A8E3BLE2
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1293592:LCU RS00620
gene id: 1293592:LCU_RS00620
uniprot id: A0A8E2X8J9
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

1293592:LCU RS00700
gene id: 1293592:LCU_RS00700
uniprot id: A0A8E2X7V9
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

1293592:LCU RS04825
gene id: 1293592:LCU_RS04825
uniprot id: A0A8E3BJF7
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1293592:LCU RS02920
gene id: 1293592:LCU_RS02920
uniprot id: A0A8E3BJ45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GpsB family.
messages: Cytoplasm
messages: Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation.
messages: Forms polymers through the coiled coil domains. Interacts with PBP1, MreC and EzrA.

1293592:LCU RS01665
gene id: 1293592:LCU_RS01665
uniprot id: A0A8E3BK47
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS07665
gene id: 1293592:LCU_RS07665
uniprot id: A0A8E2XAT4
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1293592:LCU RS07040
gene id: 1293592:LCU_RS07040
uniprot id: A0A8E2X9H1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1293592:LCU RS08125
gene id: 1293592:LCU_RS08125
uniprot id: A0A8E3BJY0
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

1293592:LCU RS02095
gene id: 1293592:LCU_RS02095
uniprot id: A0A8E2X7I9
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

1293592:LCU RS06520
gene id: 1293592:LCU_RS06520
uniprot id: A0A8E2X929
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1293592:LCU RS01500
gene id: 1293592:LCU_RS01500
uniprot id: A0A8E3BK35
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS04830
gene id: 1293592:LCU_RS04830
uniprot id: A0A8E3BKM8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1293592:LCU RS07255
gene id: 1293592:LCU_RS07255
uniprot id: A0A8E2X9F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1293592:LCU RS01050
gene id: 1293592:LCU_RS01050
uniprot id: A0A8E2X7V6
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the FGGY kinase family.
messages: Homotetramer and homodimer (in equilibrium).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), including enzyme I, and histidine-containing protein (HPr) are required for the phosphorylation, which leads to the activation of the enzyme.

1293592:LCU RS04060
gene id: 1293592:LCU_RS04060
uniprot id: A0A8E2X8B9
names: Similarity
messages: Belongs to the universal stress protein A family.

1293592:LCU RS08455
gene id: 1293592:LCU_RS08455
uniprot id: A0A8E2XA95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1293592:LCU RS07730
gene id: 1293592:LCU_RS07730
uniprot id: A0A8E2XAC3
names: Similarity
messages: Belongs to the CFA/CMAS family.

1293592:LCU RS01755
gene id: 1293592:LCU_RS01755
uniprot id: A0A8E2X881
names: Similarity
messages: Belongs to the diacylglycerol/lipid kinase family.

1293592:LCU RS00480
gene id: 1293592:LCU_RS00480
uniprot id: A0A8E2X764
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

1293592:LCU RS08760
gene id: 1293592:LCU_RS08760
uniprot id: A0A8E3BKV6
names: Subcellular Location Annotation
messages: Membrane

1293592:LCU RS05465
gene id: 1293592:LCU_RS05465
uniprot id: A0A8E3BLH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

1293592:LCU RS07660
gene id: 1293592:LCU_RS07660
uniprot id: A0A8E2XA51
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS03260
gene id: 1293592:LCU_RS03260
uniprot id: A0A8E2X9D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS02770
gene id: 1293592:LCU_RS02770
uniprot id: A0A8E2X987
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

1293592:LCU RS09100
gene id: 1293592:LCU_RS09100
uniprot id: A0A8E2XA54
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

1293592:LCU RS09530
gene id: 1293592:LCU_RS09530
uniprot id: A0A8E2XCH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Cell membrane
messages: Membrane
messages: O-acyltransferase that catalyzes D-alanylation of both teichoic acid and lipoteichoic acid (LTA). D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Catalyzes D-alanylation from DltC carrier protein.

1293592:LCU RS01520
gene id: 1293592:LCU_RS01520
uniprot id: A0A8E2X8V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

1293592:LCU RS01785
gene id: 1293592:LCU_RS01785
uniprot id: A0A8E2XAE7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1293592:LCU RS03465
gene id: 1293592:LCU_RS03465
uniprot id: A0A8E3BKD9
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1293592:LCU RS04885
gene id: 1293592:LCU_RS04885
uniprot id: A0A8E2X912
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1293592:LCU RS05200
gene id: 1293592:LCU_RS05200
uniprot id: A0A8E2X954
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

1293592:LCU RS08790
gene id: 1293592:LCU_RS08790
uniprot id: A0A8E3BLS9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1293592:LCU RS01355
gene id: 1293592:LCU_RS01355
uniprot id: A0A8E2X7Z6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1293592:LCU RS00510
gene id: 1293592:LCU_RS00510
uniprot id: A0A8E3BJJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1293592:LCU RS00345
gene id: 1293592:LCU_RS00345
uniprot id: A0A8E2X7T0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

1293592:LCU RS01415
gene id: 1293592:LCU_RS01415
uniprot id: A0A8E3BK23
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

1293592:LCU RS06270
gene id: 1293592:LCU_RS06270
uniprot id: A0A8E2XAC2
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

1293592:LCU RS07505
gene id: 1293592:LCU_RS07505
uniprot id: A0A8E2X9M2
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1293592:LCU RS07110
gene id: 1293592:LCU_RS07110
uniprot id: A0A8E2X999
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1293592:LCU RS06920
gene id: 1293592:LCU_RS06920
uniprot id: A0A8E3BJS1
names: Similarity
messages: Belongs to the diacylglycerol/lipid kinase family.

1293592:LCU RS05380
gene id: 1293592:LCU_RS05380
uniprot id: A0A8E2X973
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1293592:LCU RS00795
gene id: 1293592:LCU_RS00795
uniprot id: A0A8E2X7S5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: In the native structure, TdcB is in a dimeric form, whereas in the TdcB-AMP complex, it exists in a tetrameric form (dimer of dimers).

1293592:LCU RS07960
gene id: 1293592:LCU_RS07960
uniprot id: A0A8E3BLN2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1293592:LCU RS00380
gene id: 1293592:LCU_RS00380
uniprot id: A0A8E2X7M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

1293592:LCU RS04240
gene id: 1293592:LCU_RS04240
uniprot id: A0A8E2X8I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

1293592:LCU RS02540
gene id: 1293592:LCU_RS02540
uniprot id: A0A8E2XAP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

1293592:LCU RS07950
gene id: 1293592:LCU_RS07950
uniprot id: A0A8E3BJX1
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

1293592:LCU RS05840
gene id: 1293592:LCU_RS05840
uniprot id: A0A8E2X8U5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1293592:LCU RS07590
gene id: 1293592:LCU_RS07590
uniprot id: A0A8E2X9E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Cell membrane
messages: Component of the transport system for branched-chain amino acids.
messages: Membrane

1293592:LCU RS02800
gene id: 1293592:LCU_RS02800
uniprot id: A0A8E2XAR8
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1293592:LCU RS04275
gene id: 1293592:LCU_RS04275
uniprot id: A0A8E3BL12
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1293592:LCU RS07140
gene id: 1293592:LCU_RS07140
uniprot id: A0A8E3BL13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1293592:LCU RS01760
gene id: 1293592:LCU_RS01760
uniprot id: A0A8E2X8X9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

1293592:LCU RS06930
gene id: 1293592:LCU_RS06930
uniprot id: A0A8E3BLG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1293592:LCU RS02960
gene id: 1293592:LCU_RS02960
uniprot id: A0A8E2X7T9
names: Function
names: Similarity
messages: 3'-5' exonuclease.
messages: Belongs to the helicase family. DinG subfamily. Type 2 sub-subfamily.

1293592:LCU RS05835
gene id: 1293592:LCU_RS05835
uniprot id: A0A8E2X8Y4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1293592:LCU RS04525
gene id: 1293592:LCU_RS04525
uniprot id: A0A8E2X947
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1293592:LCU RS03330
gene id: 1293592:LCU_RS03330
uniprot id: A0A8E2X8K8
names: Similarity
messages: Belongs to the UPF0637 family.

1293592:LCU RS01660
gene id: 1293592:LCU_RS01660
uniprot id: A0A8E3BIX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

1293592:LCU RS08015
gene id: 1293592:LCU_RS08015
uniprot id: A0A8E2XAM2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpB RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpA.
messages: Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1293592:LCU RS09525
gene id: 1293592:LCU_RS09525
uniprot id: A0A8E2XAA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.
messages: Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
messages: Cytoplasm

1293592:LCU RS05085
gene id: 1293592:LCU_RS05085
uniprot id: A0A8E2X9Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1293592:LCU RS07940
gene id: 1293592:LCU_RS07940
uniprot id: A0A8E3BKR1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GdpP/PdeA phosphodiesterase family.
messages: Cell membrane
messages: For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.
messages: Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP).

1293592:LCU RS01855
gene id: 1293592:LCU_RS01855
uniprot id: A0A8E2X7H1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1293592:LCU RS09455
gene id: 1293592:LCU_RS09455
uniprot id: A0A8E2XB44
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1293592:LCU RS09670
gene id: 1293592:LCU_RS09670
uniprot id: A0A8E2XA81
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1293592:LCU RS02025
gene id: 1293592:LCU_RS02025
uniprot id: A0A8E2X7J2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1293592:LCU RS07160
gene id: 1293592:LCU_RS07160
uniprot id: A0A8E2X9U4
names: Similarity
messages: Belongs to the CtsR family.

1293592:LCU RS07535
gene id: 1293592:LCU_RS07535
uniprot id: A0A8E3BL33
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1293592:LCU RS00185
gene id: 1293592:LCU_RS00185
uniprot id: A0A8E3BJV6
names: Similarity
messages: Belongs to the RutC family.

1293592:LCU RS04705
gene id: 1293592:LCU_RS04705
uniprot id: A0A8E2X8F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1293592:LCU RS05095
gene id: 1293592:LCU_RS05095
uniprot id: A0A8E2X8P3
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1293592:LCU RS07965
gene id: 1293592:LCU_RS07965
uniprot id: A0A8E2XAQ8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1293592:LCU RS01340
gene id: 1293592:LCU_RS01340
uniprot id: A0A8E3BIV4
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

1293592:LCU RS01275
gene id: 1293592:LCU_RS01275
uniprot id: A0A8E3BKI7
names: Similarity
messages: Belongs to the asp23 family.

1293592:LCU RS09410
gene id: 1293592:LCU_RS09410
uniprot id: A0A8E2XAH2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1293592:LCU RS05900
gene id: 1293592:LCU_RS05900
uniprot id: A0A8E2X9L7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
messages: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
messages: Cytoplasm
messages: Homodimer.

1293592:LCU RS00895
gene id: 1293592:LCU_RS00895
uniprot id: A0A8E2X7X6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.