1260251:SPISAL RS02335
gene id: 1260251:SPISAL_RS02335
uniprot id: R4VJ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1260251:SPISAL RS03585
gene id: 1260251:SPISAL_RS03585
uniprot id: R4VMK4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1260251:SPISAL RS04320
gene id: 1260251:SPISAL_RS04320
uniprot id: R4VFA6
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1260251:SPISAL RS06285
gene id: 1260251:SPISAL_RS06285
uniprot id: R4VLK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.

1260251:SPISAL RS01605
gene id: 1260251:SPISAL_RS01605
uniprot id: R4V5T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1260251:SPISAL RS01915
gene id: 1260251:SPISAL_RS01915
uniprot id: R4VIR2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1260251:SPISAL RS08040
gene id: 1260251:SPISAL_RS08040
uniprot id: R4V6Y6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1260251:SPISAL RS02785
gene id: 1260251:SPISAL_RS02785
uniprot id: R4VED4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PriB family.
messages: Binds single-stranded DNA at the primosome assembly site (PAS).
messages: Component of the preprimosomal complex composed of PriA, PriB, PriC, DnaB and DnaT. Upon transient interaction with DnaG it forms the primosome.

1260251:SPISAL RS07545
gene id: 1260251:SPISAL_RS07545
uniprot id: R4V9D2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1260251:SPISAL RS02205
gene id: 1260251:SPISAL_RS02205
uniprot id: R4VIX6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the MsrP family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

1260251:SPISAL RS03840
gene id: 1260251:SPISAL_RS03840
uniprot id: R4VK05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1260251:SPISAL RS01120
gene id: 1260251:SPISAL_RS01120
uniprot id: R4V2U4
names: Subcellular Location Annotation
messages: Cytoplasm

1260251:SPISAL RS05590
gene id: 1260251:SPISAL_RS05590
uniprot id: R4V5J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1260251:SPISAL RS05835
gene id: 1260251:SPISAL_RS05835
uniprot id: R4VGC4
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1260251:SPISAL RS07435
gene id: 1260251:SPISAL_RS07435
uniprot id: R4VPZ6
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

1260251:SPISAL RS07910
gene id: 1260251:SPISAL_RS07910
uniprot id: R4VQA9
names: Similarity
messages: Belongs to the GARS family.

1260251:SPISAL RS07340
gene id: 1260251:SPISAL_RS07340
uniprot id: R4V6I8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1260251:SPISAL RS06505
gene id: 1260251:SPISAL_RS06505
uniprot id: R4VGM9
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1260251:SPISAL RS04665
gene id: 1260251:SPISAL_RS04665
uniprot id: R4V4Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamE family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

1260251:SPISAL RS03245
gene id: 1260251:SPISAL_RS03245
uniprot id: R4VJN9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1260251:SPISAL RS08490
gene id: 1260251:SPISAL_RS08490
uniprot id: R4V7A8
names: Similarity
messages: Belongs to the OsmC/Ohr family.

1260251:SPISAL RS00550
gene id: 1260251:SPISAL_RS00550
uniprot id: R4VD06
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1260251:SPISAL RS02485
gene id: 1260251:SPISAL_RS02485
uniprot id: R4VJ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS03660
gene id: 1260251:SPISAL_RS03660
uniprot id: R4VJW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial glucokinase family.
messages: Cytoplasm

1260251:SPISAL RS03640
gene id: 1260251:SPISAL_RS03640
uniprot id: R4VML4
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS02880
gene id: 1260251:SPISAL_RS02880
uniprot id: R4V6L0
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1260251:SPISAL RS00755
gene id: 1260251:SPISAL_RS00755
uniprot id: R4VI14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

1260251:SPISAL RS03955
gene id: 1260251:SPISAL_RS03955
uniprot id: R4V4J2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1260251:SPISAL RS08035
gene id: 1260251:SPISAL_RS08035
uniprot id: R4VQE2
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

1260251:SPISAL RS01525
gene id: 1260251:SPISAL_RS01525
uniprot id: R4V316
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS04015
gene id: 1260251:SPISAL_RS04015
uniprot id: R4VK40
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

1260251:SPISAL RS06605
gene id: 1260251:SPISAL_RS06605
uniprot id: R4VGQ1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

1260251:SPISAL RS08310
gene id: 1260251:SPISAL_RS08310
uniprot id: R4VQM2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1260251:SPISAL RS02005
gene id: 1260251:SPISAL_RS02005
uniprot id: R4V3B1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1260251:SPISAL RS03175
gene id: 1260251:SPISAL_RS03175
uniprot id: R4V460
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1260251:SPISAL RS07960
gene id: 1260251:SPISAL_RS07960
uniprot id: R4VQC2
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS04030
gene id: 1260251:SPISAL_RS04030
uniprot id: R4V792
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1260251:SPISAL RS04150
gene id: 1260251:SPISAL_RS04150
uniprot id: R4VF74
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1260251:SPISAL RS01435
gene id: 1260251:SPISAL_RS01435
uniprot id: R4VDH8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1260251:SPISAL RS07535
gene id: 1260251:SPISAL_RS07535
uniprot id: R4VQ25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1260251:SPISAL RS06475
gene id: 1260251:SPISAL_RS06475
uniprot id: R4V8R0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1260251:SPISAL RS08075
gene id: 1260251:SPISAL_RS08075
uniprot id: R4VHM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1260251:SPISAL RS07525
gene id: 1260251:SPISAL_RS07525
uniprot id: R4VHB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1260251:SPISAL RS02080
gene id: 1260251:SPISAL_RS02080
uniprot id: R4VIU7
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

1260251:SPISAL RS07835
gene id: 1260251:SPISAL_RS07835
uniprot id: R4VQ89
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS04675
gene id: 1260251:SPISAL_RS04675
uniprot id: R4VFI7
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

1260251:SPISAL RS07345
gene id: 1260251:SPISAL_RS07345
uniprot id: R4V988
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

1260251:SPISAL RS06385
gene id: 1260251:SPISAL_RS06385
uniprot id: R4VLM4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

1260251:SPISAL RS06090
gene id: 1260251:SPISAL_RS06090
uniprot id: R4VLG9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS06830
gene id: 1260251:SPISAL_RS06830
uniprot id: R4V8Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1260251:SPISAL RS04280
gene id: 1260251:SPISAL_RS04280
uniprot id: R4VMY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
messages: Cytoplasm
messages: Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.

1260251:SPISAL RS06730
gene id: 1260251:SPISAL_RS06730
uniprot id: R4VGS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS05830
gene id: 1260251:SPISAL_RS05830
uniprot id: R4V8E7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1260251:SPISAL RS03320
gene id: 1260251:SPISAL_RS03320
uniprot id: R4VJQ3
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS02490
gene id: 1260251:SPISAL_RS02490
uniprot id: R4VLV4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1260251:SPISAL RS06970
gene id: 1260251:SPISAL_RS06970
uniprot id: R4VLX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsL family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Membrane
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

1260251:SPISAL RS06950
gene id: 1260251:SPISAL_RS06950
uniprot id: R4VPN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS02210
gene id: 1260251:SPISAL_RS02210
uniprot id: R4VLP8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrQ family.
messages: Binds 1 FMN per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.

1260251:SPISAL RS01695
gene id: 1260251:SPISAL_RS01695
uniprot id: R4VLE1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1260251:SPISAL RS05895
gene id: 1260251:SPISAL_RS05895
uniprot id: R4VP35
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

1260251:SPISAL RS08335
gene id: 1260251:SPISAL_RS08335
uniprot id: R4VQM4
names: Function
names: Similarity
names: Subunit
messages: Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
messages: Belongs to the ZapA family. Type 1 subfamily.
messages: Homodimer. Interacts with FtsZ.

1260251:SPISAL RS07075
gene id: 1260251:SPISAL_RS07075
uniprot id: R4VPR4
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS07470
gene id: 1260251:SPISAL_RS07470
uniprot id: R4V9B4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1260251:SPISAL RS08210
gene id: 1260251:SPISAL_RS08210
uniprot id: R4VQI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1260251:SPISAL RS07785
gene id: 1260251:SPISAL_RS07785
uniprot id: R4V6T1
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS04295
gene id: 1260251:SPISAL_RS04295
uniprot id: R4VFA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1260251:SPISAL RS01575
gene id: 1260251:SPISAL_RS01575
uniprot id: R4V323
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AFG1 ATPase family. ZapE subfamily.
messages: Cytoplasm
messages: Interacts with FtsZ.
messages: Reduces the stability of FtsZ polymers in the presence of ATP.

1260251:SPISAL RS01530
gene id: 1260251:SPISAL_RS01530
uniprot id: R4V5R5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

1260251:SPISAL RS03435
gene id: 1260251:SPISAL_RS03435
uniprot id: R4V6Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1260251:SPISAL RS07650
gene id: 1260251:SPISAL_RS07650
uniprot id: R4VHE3
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1260251:SPISAL RS07560
gene id: 1260251:SPISAL_RS07560
uniprot id: R4VQ32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1260251:SPISAL RS02970
gene id: 1260251:SPISAL_RS02970
uniprot id: R4V3W7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

1260251:SPISAL RS00350
gene id: 1260251:SPISAL_RS00350
uniprot id: R4VHS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1260251:SPISAL RS04070
gene id: 1260251:SPISAL_RS04070
uniprot id: R4V798
names: Similarity
messages: Belongs to the UPF0260 family.

1260251:SPISAL RS07250
gene id: 1260251:SPISAL_RS07250
uniprot id: R4VH45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Cell inner membrane
messages: Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.
messages: Membrane

1260251:SPISAL RS06665
gene id: 1260251:SPISAL_RS06665
uniprot id: R4VPH8
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS04615
gene id: 1260251:SPISAL_RS04615
uniprot id: R4V4X1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

1260251:SPISAL RS00260
gene id: 1260251:SPISAL_RS00260
uniprot id: R4V281
names: Similarity
messages: Belongs to the Smg family.

1260251:SPISAL RS08050
gene id: 1260251:SPISAL_RS08050
uniprot id: R4VHM3
names: Similarity
messages: Belongs to the FrmR/RcnR family.

1260251:SPISAL RS03965
gene id: 1260251:SPISAL_RS03965
uniprot id: R4VF36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1260251:SPISAL RS02400
gene id: 1260251:SPISAL_RS02400
uniprot id: R4V699
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1260251:SPISAL RS06925
gene id: 1260251:SPISAL_RS06925
uniprot id: R4VPM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1260251:SPISAL RS00395
gene id: 1260251:SPISAL_RS00395
uniprot id: R4VCW8
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Homodimer.
messages: Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.
messages: The transmembrane domain is a dimerization domain.

1260251:SPISAL RS04300
gene id: 1260251:SPISAL_RS04300
uniprot id: R4VK96
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

1260251:SPISAL RS01775
gene id: 1260251:SPISAL_RS01775
uniprot id: R4V363
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1260251:SPISAL RS05735
gene id: 1260251:SPISAL_RS05735
uniprot id: R4V5P9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1260251:SPISAL RS03510
gene id: 1260251:SPISAL_RS03510
uniprot id: R4V708
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine.

1260251:SPISAL RS01875
gene id: 1260251:SPISAL_RS01875
uniprot id: R4V385
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS04210
gene id: 1260251:SPISAL_RS04210
uniprot id: R4V4P1
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

1260251:SPISAL RS07325
gene id: 1260251:SPISAL_RS07325
uniprot id: R4VH65
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

1260251:SPISAL RS06395
gene id: 1260251:SPISAL_RS06395
uniprot id: R4V607
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Monomer.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

1260251:SPISAL RS08465
gene id: 1260251:SPISAL_RS08465
uniprot id: R4V7A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 9 family.
messages: Periplasm

1260251:SPISAL RS01370
gene id: 1260251:SPISAL_RS01370
uniprot id: R4VL76
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS02885
gene id: 1260251:SPISAL_RS02885
uniprot id: R4VEF5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

1260251:SPISAL RS00555
gene id: 1260251:SPISAL_RS00555
uniprot id: R4VHY4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably interacts with PlsX.

1260251:SPISAL RS02530
gene id: 1260251:SPISAL_RS02530
uniprot id: R4VE65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1260251:SPISAL RS06250
gene id: 1260251:SPISAL_RS06250
uniprot id: R4V8L0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein.

1260251:SPISAL RS05665
gene id: 1260251:SPISAL_RS05665
uniprot id: R4V8A8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1260251:SPISAL RS07970
gene id: 1260251:SPISAL_RS07970
uniprot id: R4V9N2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

1260251:SPISAL RS08400
gene id: 1260251:SPISAL_RS08400
uniprot id: R4VHW5
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS04060
gene id: 1260251:SPISAL_RS04060
uniprot id: R4VMT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

1260251:SPISAL RS05620
gene id: 1260251:SPISAL_RS05620
uniprot id: R4V894
names: Similarity
messages: Belongs to the SdhE FAD assembly factor family.

1260251:SPISAL RS01745
gene id: 1260251:SPISAL_RS01745
uniprot id: R4VLF4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

1260251:SPISAL RS06655
gene id: 1260251:SPISAL_RS06655
uniprot id: R4VGR1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1260251:SPISAL RS00215
gene id: 1260251:SPISAL_RS00215
uniprot id: R4V4Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

1260251:SPISAL RS02355
gene id: 1260251:SPISAL_RS02355
uniprot id: R4VE21
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1260251:SPISAL RS06845
gene id: 1260251:SPISAL_RS06845
uniprot id: R4VPL2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1260251:SPISAL RS07955
gene id: 1260251:SPISAL_RS07955
uniprot id: R4VMI7
names: Function
names: Similarity
messages: Belongs to the MurCDEF family. Mpl subfamily.
messages: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.

1260251:SPISAL RS02130
gene id: 1260251:SPISAL_RS02130
uniprot id: R4VIV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1260251:SPISAL RS03455
gene id: 1260251:SPISAL_RS03455
uniprot id: R4V4B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapB family.
messages: Cell inner membrane
messages: Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.

1260251:SPISAL RS06050
gene id: 1260251:SPISAL_RS06050
uniprot id: R4V5U4
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS05025
gene id: 1260251:SPISAL_RS05025
uniprot id: R4VNE4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1260251:SPISAL RS03505
gene id: 1260251:SPISAL_RS03505
uniprot id: R4V4C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1260251:SPISAL RS06955
gene id: 1260251:SPISAL_RS06955
uniprot id: R4V6A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1260251:SPISAL RS05100
gene id: 1260251:SPISAL_RS05100
uniprot id: R4VNG2
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS04220
gene id: 1260251:SPISAL_RS04220
uniprot id: R4VF89
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

1260251:SPISAL RS05030
gene id: 1260251:SPISAL_RS05030
uniprot id: R4V571
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

1260251:SPISAL RS04130
gene id: 1260251:SPISAL_RS04130
uniprot id: R4VK59
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1260251:SPISAL RS04200
gene id: 1260251:SPISAL_RS04200
uniprot id: R4VK73
names: Similarity
messages: Belongs to the GcvT family.

1260251:SPISAL RS07400
gene id: 1260251:SPISAL_RS07400
uniprot id: R4VH84
names: Similarity
messages: Belongs to the PhoH family.

1260251:SPISAL RS03860
gene id: 1260251:SPISAL_RS03860
uniprot id: R4VF17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

1260251:SPISAL RS02505
gene id: 1260251:SPISAL_RS02505
uniprot id: R4VE57
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1260251:SPISAL RS08280
gene id: 1260251:SPISAL_RS08280
uniprot id: R4VMT7
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1260251:SPISAL RS03335
gene id: 1260251:SPISAL_RS03335
uniprot id: R4V6Y3
names: Similarity
messages: Belongs to the YciI family.

1260251:SPISAL RS06460
gene id: 1260251:SPISAL_RS06460
uniprot id: R4VLN7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

1260251:SPISAL RS00570
gene id: 1260251:SPISAL_RS00570
uniprot id: R4V599
names: Subcellular Location Annotation
messages: Mitochondrion

1260251:SPISAL RS08305
gene id: 1260251:SPISAL_RS08305
uniprot id: R4VMU1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1260251:SPISAL RS07870
gene id: 1260251:SPISAL_RS07870
uniprot id: R4V9K6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

1260251:SPISAL RS02450
gene id: 1260251:SPISAL_RS02450
uniprot id: R4V6B2
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.

1260251:SPISAL RS04140
gene id: 1260251:SPISAL_RS04140
uniprot id: R4V4M6
names: Subunit
messages: Homodimer.

1260251:SPISAL RS07445
gene id: 1260251:SPISAL_RS07445
uniprot id: R4V9A9
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS00600
gene id: 1260251:SPISAL_RS00600
uniprot id: R4VD46
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1260251:SPISAL RS00530
gene id: 1260251:SPISAL_RS00530
uniprot id: R4VHV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1260251:SPISAL RS03460
gene id: 1260251:SPISAL_RS03460
uniprot id: R4V701
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

1260251:SPISAL RS00090
gene id: 1260251:SPISAL_RS00090
uniprot id: R4V244
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC1 family. UbiB subfamily.
messages: Cell membrane
messages: Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS04090
gene id: 1260251:SPISAL_RS04090
uniprot id: R4V4L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS04780
gene id: 1260251:SPISAL_RS04780
uniprot id: R4VKJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

1260251:SPISAL RS02515
gene id: 1260251:SPISAL_RS02515
uniprot id: R4VLV8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS06055
gene id: 1260251:SPISAL_RS06055
uniprot id: R4V8H1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

1260251:SPISAL RS06225
gene id: 1260251:SPISAL_RS06225
uniprot id: R4V8K4
names: Similarity
messages: Belongs to the KAE1 / TsaD family. TsaB subfamily.

1260251:SPISAL RS01495
gene id: 1260251:SPISAL_RS01495
uniprot id: R4VL99
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Cell membrane
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

1260251:SPISAL RS04230
gene id: 1260251:SPISAL_RS04230
uniprot id: R4VMX2
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

1260251:SPISAL RS01240
gene id: 1260251:SPISAL_RS01240
uniprot id: R4VIA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Heterodimer of an alpha and a beta chain.
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1260251:SPISAL RS06135
gene id: 1260251:SPISAL_RS06135
uniprot id: R4VGH1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1260251:SPISAL RS00200
gene id: 1260251:SPISAL_RS00200
uniprot id: R4VHP3
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1260251:SPISAL RS01465
gene id: 1260251:SPISAL_RS01465
uniprot id: R4VIG2
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

1260251:SPISAL RS00120
gene id: 1260251:SPISAL_RS00120
uniprot id: R4V4W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1260251:SPISAL RS03450
gene id: 1260251:SPISAL_RS03450
uniprot id: R4VMI2
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS05930
gene id: 1260251:SPISAL_RS05930
uniprot id: R4V8F6
names: Similarity
messages: Belongs to the ClpA/ClpB family.

1260251:SPISAL RS02375
gene id: 1260251:SPISAL_RS02375
uniprot id: R4V695
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

1260251:SPISAL RS00695
gene id: 1260251:SPISAL_RS00695
uniprot id: R4V5D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

1260251:SPISAL RS02800
gene id: 1260251:SPISAL_RS02800
uniprot id: R4V3S2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1260251:SPISAL RS05690
gene id: 1260251:SPISAL_RS05690
uniprot id: R4V8D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1260251:SPISAL RS04485
gene id: 1260251:SPISAL_RS04485
uniprot id: R4VN27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsB family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

1260251:SPISAL RS07375
gene id: 1260251:SPISAL_RS07375
uniprot id: R4VH78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1260251:SPISAL RS05575
gene id: 1260251:SPISAL_RS05575
uniprot id: R4VG55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1260251:SPISAL RS03805
gene id: 1260251:SPISAL_RS03805
uniprot id: R4V750
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS02555
gene id: 1260251:SPISAL_RS02555
uniprot id: R4VE72
names: Similarity
messages: Belongs to the acylphosphatase family.

1260251:SPISAL RS04490
gene id: 1260251:SPISAL_RS04490
uniprot id: R4V4U6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1260251:SPISAL RS03195
gene id: 1260251:SPISAL_RS03195
uniprot id: R4VMD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1260251:SPISAL RS03830
gene id: 1260251:SPISAL_RS03830
uniprot id: R4V755
names: Similarity
messages: Belongs to the universal stress protein A family.

1260251:SPISAL RS07360
gene id: 1260251:SPISAL_RS07360
uniprot id: R4VPX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1260251:SPISAL RS04920
gene id: 1260251:SPISAL_RS04920
uniprot id: R4VKL7
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaved by autocatalysis into a large and a small subunit.
messages: This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.

1260251:SPISAL RS05385
gene id: 1260251:SPISAL_RS05385
uniprot id: R4V837
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS01780
gene id: 1260251:SPISAL_RS01780
uniprot id: R4V5X0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1260251:SPISAL RS03110
gene id: 1260251:SPISAL_RS03110
uniprot id: R4VJH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

1260251:SPISAL RS03255
gene id: 1260251:SPISAL_RS03255
uniprot id: R4V475
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1260251:SPISAL RS07570
gene id: 1260251:SPISAL_RS07570
uniprot id: R4V9D8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1260251:SPISAL RS03025
gene id: 1260251:SPISAL_RS03025
uniprot id: R4V6N6
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

1260251:SPISAL RS07630
gene id: 1260251:SPISAL_RS07630
uniprot id: R4VMC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1260251:SPISAL RS07420
gene id: 1260251:SPISAL_RS07420
uniprot id: R4V9A4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: Homohexamer; trimer of homodimers.

1260251:SPISAL RS03060
gene id: 1260251:SPISAL_RS03060
uniprot id: R4VJG3
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS02525
gene id: 1260251:SPISAL_RS02525
uniprot id: R4V6D0
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

1260251:SPISAL RS00065
gene id: 1260251:SPISAL_RS00065
uniprot id: R4V239
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1260251:SPISAL RS07010
gene id: 1260251:SPISAL_RS07010
uniprot id: R4V922
names: Cofactor
messages: Binds 1 heme c group covalently per subunit.

1260251:SPISAL RS02980
gene id: 1260251:SPISAL_RS02980
uniprot id: R4VEH4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1260251:SPISAL RS06235
gene id: 1260251:SPISAL_RS06235
uniprot id: R4VLJ8
names: Function
names: Similarity
messages: Belongs to the acetyltransferase family. EctA subfamily.
messages: Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A.

1260251:SPISAL RS06430
gene id: 1260251:SPISAL_RS06430
uniprot id: R4VGL7
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

1260251:SPISAL RS00610
gene id: 1260251:SPISAL_RS00610
uniprot id: R4VKT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1260251:SPISAL RS01925
gene id: 1260251:SPISAL_RS01925
uniprot id: R4V395
names: Similarity
messages: Belongs to the P(II) protein family.

1260251:SPISAL RS00505
gene id: 1260251:SPISAL_RS00505
uniprot id: R4VKM9
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1260251:SPISAL RS03075
gene id: 1260251:SPISAL_RS03075
uniprot id: R4V6P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone-like protein H-NS family.
messages: nucleoid

1260251:SPISAL RS05725
gene id: 1260251:SPISAL_RS05725
uniprot id: R4VLA7
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1260251:SPISAL RS01350
gene id: 1260251:SPISAL_RS01350
uniprot id: R4V2Y6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS01885
gene id: 1260251:SPISAL_RS01885
uniprot id: R4VDS6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1260251:SPISAL RS06555
gene id: 1260251:SPISAL_RS06555
uniprot id: R4VGP0
names: Similarity
messages: Belongs to the TrpF family.

1260251:SPISAL RS03420
gene id: 1260251:SPISAL_RS03420
uniprot id: R4VJS4
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

1260251:SPISAL RS06480
gene id: 1260251:SPISAL_RS06480
uniprot id: R4VGM6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1260251:SPISAL RS00865
gene id: 1260251:SPISAL_RS00865
uniprot id: R4V5G2
names: Similarity
messages: Belongs to the GcvT family.

1260251:SPISAL RS08275
gene id: 1260251:SPISAL_RS08275
uniprot id: R4VHT6
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1260251:SPISAL RS01445
gene id: 1260251:SPISAL_RS01445
uniprot id: R4VL91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1260251:SPISAL RS00060
gene id: 1260251:SPISAL_RS00060
uniprot id: R4VKD3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

1260251:SPISAL RS02470
gene id: 1260251:SPISAL_RS02470
uniprot id: R4V3K7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

1260251:SPISAL RS05335
gene id: 1260251:SPISAL_RS05335
uniprot id: R4V824
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

1260251:SPISAL RS06125
gene id: 1260251:SPISAL_RS06125
uniprot id: R4V5V8
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS03525
gene id: 1260251:SPISAL_RS03525
uniprot id: R4VJU2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1260251:SPISAL RS00720
gene id: 1260251:SPISAL_RS00720
uniprot id: R4V5D6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1260251:SPISAL RS00640
gene id: 1260251:SPISAL_RS00640
uniprot id: R4V2K8
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

1260251:SPISAL RS02295
gene id: 1260251:SPISAL_RS02295
uniprot id: R4V682
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1260251:SPISAL RS04425
gene id: 1260251:SPISAL_RS04425
uniprot id: R4VFC9
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1260251:SPISAL RS00365
gene id: 1260251:SPISAL_RS00365
uniprot id: R4V533
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1260251:SPISAL RS08530
gene id: 1260251:SPISAL_RS08530
uniprot id: R4VMY0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS08455
gene id: 1260251:SPISAL_RS08455
uniprot id: R4VMW9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1260251:SPISAL RS02385
gene id: 1260251:SPISAL_RS02385
uniprot id: R4VJ14
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1260251:SPISAL RS00630
gene id: 1260251:SPISAL_RS00630
uniprot id: R4VHZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1260251:SPISAL RS05095
gene id: 1260251:SPISAL_RS05095
uniprot id: R4VKQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

1260251:SPISAL RS07585
gene id: 1260251:SPISAL_RS07585
uniprot id: R4VQ38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1260251:SPISAL RS06765
gene id: 1260251:SPISAL_RS06765
uniprot id: R4VPJ6
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS06580
gene id: 1260251:SPISAL_RS06580
uniprot id: R4VGP6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1260251:SPISAL RS01070
gene id: 1260251:SPISAL_RS01070
uniprot id: R4V2T5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

1260251:SPISAL RS00935
gene id: 1260251:SPISAL_RS00935
uniprot id: R4VKZ6
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

1260251:SPISAL RS06695
gene id: 1260251:SPISAL_RS06695
uniprot id: R4V663
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1260251:SPISAL RS07385
gene id: 1260251:SPISAL_RS07385
uniprot id: R4VPY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS05770
gene id: 1260251:SPISAL_RS05770
uniprot id: R4VGB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1260251:SPISAL RS07935
gene id: 1260251:SPISAL_RS07935
uniprot id: R4VQB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1260251:SPISAL RS08055
gene id: 1260251:SPISAL_RS08055
uniprot id: R4VML2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1260251:SPISAL RS05610
gene id: 1260251:SPISAL_RS05610
uniprot id: R4VNU8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1260251:SPISAL RS01365
gene id: 1260251:SPISAL_RS01365
uniprot id: R4VID7
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

1260251:SPISAL RS00320
gene id: 1260251:SPISAL_RS00320
uniprot id: R4VCU8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1260251:SPISAL RS05450
gene id: 1260251:SPISAL_RS05450
uniprot id: R4VL00
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1260251:SPISAL RS03015
gene id: 1260251:SPISAL_RS03015
uniprot id: R4VM61
names: Similarity
messages: Belongs to the HesB/IscA family.

1260251:SPISAL RS02965
gene id: 1260251:SPISAL_RS02965
uniprot id: R4VM51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1260251:SPISAL RS03790
gene id: 1260251:SPISAL_RS03790
uniprot id: R4VJZ4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1260251:SPISAL RS03690
gene id: 1260251:SPISAL_RS03690
uniprot id: R4VMM4
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1260251:SPISAL RS03145
gene id: 1260251:SPISAL_RS03145
uniprot id: R4VMB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1260251:SPISAL RS06870
gene id: 1260251:SPISAL_RS06870
uniprot id: R4VLV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapD family.
messages: Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
messages: Cytoplasm
messages: Interacts with FtsZ.

1260251:SPISAL RS04455
gene id: 1260251:SPISAL_RS04455
uniprot id: R4VKC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

1260251:SPISAL RS00220
gene id: 1260251:SPISAL_RS00220
uniprot id: R4VCS1
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

1260251:SPISAL RS04190
gene id: 1260251:SPISAL_RS04190
uniprot id: R4V7C5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1260251:SPISAL RS06020
gene id: 1260251:SPISAL_RS06020
uniprot id: R4VP55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

1260251:SPISAL RS07840
gene id: 1260251:SPISAL_RS07840
uniprot id: R4V6T7
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

1260251:SPISAL RS07655
gene id: 1260251:SPISAL_RS07655
uniprot id: R4VMC6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS08680
gene id: 1260251:SPISAL_RS08680
uniprot id: R4VKS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CopD family.
messages: Cell inner membrane
messages: Involved in copper resistance.
messages: Membrane

1260251:SPISAL RS01005
gene id: 1260251:SPISAL_RS01005
uniprot id: R4VDB3
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1260251:SPISAL RS04565
gene id: 1260251:SPISAL_RS04565
uniprot id: R4V4W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

1260251:SPISAL RS00535
gene id: 1260251:SPISAL_RS00535
uniprot id: R4VKN4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1260251:SPISAL RS04145
gene id: 1260251:SPISAL_RS04145
uniprot id: R4V7B3
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

1260251:SPISAL RS04695
gene id: 1260251:SPISAL_RS04695
uniprot id: R4V7N4
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

1260251:SPISAL RS02185
gene id: 1260251:SPISAL_RS02185
uniprot id: R4VLP4
names: Subcellular Location Annotation
messages: Cytoplasm

1260251:SPISAL RS08025
gene id: 1260251:SPISAL_RS08025
uniprot id: R4VHL5
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

1260251:SPISAL RS02830
gene id: 1260251:SPISAL_RS02830
uniprot id: R4V3T1
names: Similarity
messages: Belongs to the DEAD box helicase family.

1260251:SPISAL RS03100
gene id: 1260251:SPISAL_RS03100
uniprot id: R4V6Q6
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS04055
gene id: 1260251:SPISAL_RS04055
uniprot id: R4VK45
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

1260251:SPISAL RS00515
gene id: 1260251:SPISAL_RS00515
uniprot id: R4V574
names: Function
names: Similarity
messages: Belongs to the TenA family.
messages: Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.

1260251:SPISAL RS02640
gene id: 1260251:SPISAL_RS02640
uniprot id: R4VLY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

1260251:SPISAL RS01360
gene id: 1260251:SPISAL_RS01360
uniprot id: R4VDG7
names: Similarity
messages: Belongs to the glutamate synthase family.

1260251:SPISAL RS07865
gene id: 1260251:SPISAL_RS07865
uniprot id: R4V6U2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1260251:SPISAL RS08110
gene id: 1260251:SPISAL_RS08110
uniprot id: R4VQG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

1260251:SPISAL RS07505
gene id: 1260251:SPISAL_RS07505
uniprot id: R4VM90
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1260251:SPISAL RS03445
gene id: 1260251:SPISAL_RS03445
uniprot id: R4VJS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

1260251:SPISAL RS07540
gene id: 1260251:SPISAL_RS07540
uniprot id: R4V6M9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1260251:SPISAL RS08565
gene id: 1260251:SPISAL_RS08565
uniprot id: R4V7C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1260251:SPISAL RS00085
gene id: 1260251:SPISAL_RS00085
uniprot id: R4VKD9
names: Similarity
messages: Belongs to the peptidase S41A family.

1260251:SPISAL RS03620
gene id: 1260251:SPISAL_RS03620
uniprot id: R4V4D6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

1260251:SPISAL RS00205
gene id: 1260251:SPISAL_RS00205
uniprot id: R4VKG6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

1260251:SPISAL RS02775
gene id: 1260251:SPISAL_RS02775
uniprot id: R4V3R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
messages: Cytoplasm
messages: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.

1260251:SPISAL RS00845
gene id: 1260251:SPISAL_RS00845
uniprot id: R4VD89
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

1260251:SPISAL RS03200
gene id: 1260251:SPISAL_RS03200
uniprot id: R4V465
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS07775
gene id: 1260251:SPISAL_RS07775
uniprot id: R4VMF0
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1260251:SPISAL RS01890
gene id: 1260251:SPISAL_RS01890
uniprot id: R4VIQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1260251:SPISAL RS07520
gene id: 1260251:SPISAL_RS07520
uniprot id: R4V9C4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1260251:SPISAL RS06540
gene id: 1260251:SPISAL_RS06540
uniprot id: R4VPF3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1260251:SPISAL RS06920
gene id: 1260251:SPISAL_RS06920
uniprot id: R4VLW6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1260251:SPISAL RS04135
gene id: 1260251:SPISAL_RS04135
uniprot id: R4VMV2
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

1260251:SPISAL RS07915
gene id: 1260251:SPISAL_RS07915
uniprot id: R4V6V4
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1260251:SPISAL RS06600
gene id: 1260251:SPISAL_RS06600
uniprot id: R4V8T7
names: Similarity
messages: Belongs to the SCO1/2 family.

1260251:SPISAL RS03530
gene id: 1260251:SPISAL_RS03530
uniprot id: R4VMJ6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1260251:SPISAL RS05245
gene id: 1260251:SPISAL_RS05245
uniprot id: R4VKU0
names: Function
names: Similarity
messages: Belongs to the esterase D family.
messages: Serine hydrolase involved in the detoxification of formaldehyde.

1260251:SPISAL RS00360
gene id: 1260251:SPISAL_RS00360
uniprot id: R4V2A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1260251:SPISAL RS04520
gene id: 1260251:SPISAL_RS04520
uniprot id: R4V7J5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1260251:SPISAL RS03820
gene id: 1260251:SPISAL_RS03820
uniprot id: R4VMP9
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1260251:SPISAL RS03730
gene id: 1260251:SPISAL_RS03730
uniprot id: R4VEZ2
names: Function
names: Similarity
messages: Belongs to the FlgA family.
messages: Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.

1260251:SPISAL RS05960
gene id: 1260251:SPISAL_RS05960
uniprot id: R4VGE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1260251:SPISAL RS06690
gene id: 1260251:SPISAL_RS06690
uniprot id: R4VPI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1260251:SPISAL RS05985
gene id: 1260251:SPISAL_RS05985
uniprot id: R4VGE8
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

1260251:SPISAL RS07310
gene id: 1260251:SPISAL_RS07310
uniprot id: R4VPV9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

1260251:SPISAL RS01225
gene id: 1260251:SPISAL_RS01225
uniprot id: R4V2W4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

1260251:SPISAL RS00325
gene id: 1260251:SPISAL_RS00325
uniprot id: R4VHR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1260251:SPISAL RS06165
gene id: 1260251:SPISAL_RS06165
uniprot id: R4VP79
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS04550
gene id: 1260251:SPISAL_RS04550
uniprot id: R4VFF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

1260251:SPISAL RS07370
gene id: 1260251:SPISAL_RS07370
uniprot id: R4V995
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptE lipoprotein family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.
messages: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.

1260251:SPISAL RS08345
gene id: 1260251:SPISAL_RS08345
uniprot id: R4V9Y7
names: Subcellular Location Annotation
messages: Nucleus

1260251:SPISAL RS06835
gene id: 1260251:SPISAL_RS06835
uniprot id: R4VGU9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1260251:SPISAL RS07065
gene id: 1260251:SPISAL_RS07065
uniprot id: R4VH03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).

1260251:SPISAL RS01050
gene id: 1260251:SPISAL_RS01050
uniprot id: R4V5I9
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

1260251:SPISAL RS05865
gene id: 1260251:SPISAL_RS05865
uniprot id: R4VLD0
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1260251:SPISAL RS00605
gene id: 1260251:SPISAL_RS00605
uniprot id: R4VHZ2
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1260251:SPISAL RS00355
gene id: 1260251:SPISAL_RS00355
uniprot id: R4VKJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1260251:SPISAL RS03170
gene id: 1260251:SPISAL_RS03170
uniprot id: R4VMC9
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

1260251:SPISAL RS04470
gene id: 1260251:SPISAL_RS04470
uniprot id: R4V7I4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

1260251:SPISAL RS01845
gene id: 1260251:SPISAL_RS01845
uniprot id: R4VIP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Membrane

1260251:SPISAL RS03850
gene id: 1260251:SPISAL_RS03850
uniprot id: R4V4H3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1260251:SPISAL RS02715
gene id: 1260251:SPISAL_RS02715
uniprot id: R4VLZ9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1260251:SPISAL RS03720
gene id: 1260251:SPISAL_RS03720
uniprot id: R4V4F1
names: Similarity
messages: Belongs to the GSP E family.

1260251:SPISAL RS05115
gene id: 1260251:SPISAL_RS05115
uniprot id: R4VFV5
names: Similarity
messages: Belongs to the UPF0178 family.

1260251:SPISAL RS00880
gene id: 1260251:SPISAL_RS00880
uniprot id: R4VKY6
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1260251:SPISAL RS07530
gene id: 1260251:SPISAL_RS07530
uniprot id: R4VM96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1260251:SPISAL RS01075
gene id: 1260251:SPISAL_RS01075
uniprot id: R4V5J4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

1260251:SPISAL RS08340
gene id: 1260251:SPISAL_RS08340
uniprot id: R4V782
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1260251:SPISAL RS07920
gene id: 1260251:SPISAL_RS07920
uniprot id: R4V9M0
names: Similarity
messages: Belongs to the transcriptional regulatory Fis family.

1260251:SPISAL RS06660
gene id: 1260251:SPISAL_RS06660
uniprot id: R4VLS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1260251:SPISAL RS06275
gene id: 1260251:SPISAL_RS06275
uniprot id: R4V8L5
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS03155
gene id: 1260251:SPISAL_RS03155
uniprot id: R4V6U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1260251:SPISAL RS01680
gene id: 1260251:SPISAL_RS01680
uniprot id: R4V5U7
names: Similarity
messages: Belongs to the pyruvate kinase family.

1260251:SPISAL RS05925
gene id: 1260251:SPISAL_RS05925
uniprot id: R4V5S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1260251:SPISAL RS07035
gene id: 1260251:SPISAL_RS07035
uniprot id: R4V927
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1260251:SPISAL RS08730
gene id: 1260251:SPISAL_RS08730
uniprot id: R4VA31
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1260251:SPISAL RS02855
gene id: 1260251:SPISAL_RS02855
uniprot id: R4VEE8
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

1260251:SPISAL RS01375
gene id: 1260251:SPISAL_RS01375
uniprot id: R4V2Z0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1260251:SPISAL RS03705
gene id: 1260251:SPISAL_RS03705
uniprot id: R4VEY8
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

1260251:SPISAL RS02790
gene id: 1260251:SPISAL_RS02790
uniprot id: R4VJA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

1260251:SPISAL RS02615
gene id: 1260251:SPISAL_RS02615
uniprot id: R4VLX8
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS00010
gene id: 1260251:SPISAL_RS00010
uniprot id: R4VKC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1260251:SPISAL RS01415
gene id: 1260251:SPISAL_RS01415
uniprot id: R4VIE9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

1260251:SPISAL RS01090
gene id: 1260251:SPISAL_RS01090
uniprot id: R4VL25
names: Similarity
messages: Belongs to the peptidase M16 family.

1260251:SPISAL RS02175
gene id: 1260251:SPISAL_RS02175
uniprot id: R4VDY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1260251:SPISAL RS03055
gene id: 1260251:SPISAL_RS03055
uniprot id: R4VEJ5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1260251:SPISAL RS01220
gene id: 1260251:SPISAL_RS01220
uniprot id: R4VL49
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1260251:SPISAL RS08695
gene id: 1260251:SPISAL_RS08695
uniprot id: R4VGG4
names: Similarity
messages: Belongs to the phosphoribulokinase family.

1260251:SPISAL RS04180
gene id: 1260251:SPISAL_RS04180
uniprot id: R4VMW2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YceF subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1260251:SPISAL RS03105
gene id: 1260251:SPISAL_RS03105
uniprot id: R4VEL0
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1260251:SPISAL RS02480
gene id: 1260251:SPISAL_RS02480
uniprot id: R4VE51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS04585
gene id: 1260251:SPISAL_RS04585
uniprot id: R4VN45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1260251:SPISAL RS01595
gene id: 1260251:SPISAL_RS01595
uniprot id: R4VLB9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.

1260251:SPISAL RS05250
gene id: 1260251:SPISAL_RS05250
uniprot id: R4VNJ7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

1260251:SPISAL RS07930
gene id: 1260251:SPISAL_RS07930
uniprot id: R4VMI1
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

1260251:SPISAL RS05950
gene id: 1260251:SPISAL_RS05950
uniprot id: R4V5S7
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

1260251:SPISAL RS04670
gene id: 1260251:SPISAL_RS04670
uniprot id: R4V7M8
names: Similarity
messages: Belongs to the UPF0125 (RnfH) family.

1260251:SPISAL RS08285
gene id: 1260251:SPISAL_RS08285
uniprot id: R4VQL8
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

1260251:SPISAL RS05980
gene id: 1260251:SPISAL_RS05980
uniprot id: R4V8G3
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1260251:SPISAL RS06940
gene id: 1260251:SPISAL_RS06940
uniprot id: R4VGX2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. FtsW subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell division.

1260251:SPISAL RS03210
gene id: 1260251:SPISAL_RS03210
uniprot id: R4VER0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1260251:SPISAL RS06795
gene id: 1260251:SPISAL_RS06795
uniprot id: R4VPK0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

1260251:SPISAL RS08440
gene id: 1260251:SPISAL_RS08440
uniprot id: R4V7A0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1260251:SPISAL RS05790
gene id: 1260251:SPISAL_RS05790
uniprot id: R4VP16
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

1260251:SPISAL RS05580
gene id: 1260251:SPISAL_RS05580
uniprot id: R4VL36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1260251:SPISAL RS01545
gene id: 1260251:SPISAL_RS01545
uniprot id: R4VLA9
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

1260251:SPISAL RS03575
gene id: 1260251:SPISAL_RS03575
uniprot id: R4VEW7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

1260251:SPISAL RS03855
gene id: 1260251:SPISAL_RS03855
uniprot id: R4V759
names: Similarity
messages: Belongs to the aspartokinase family.

1260251:SPISAL RS05870
gene id: 1260251:SPISAL_RS05870
uniprot id: R4VP30
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS01985
gene id: 1260251:SPISAL_RS01985
uniprot id: R4VDU9
names: Similarity
messages: Belongs to the Dps family.

1260251:SPISAL RS04800
gene id: 1260251:SPISAL_RS04800
uniprot id: R4VFL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1260251:SPISAL RS05020
gene id: 1260251:SPISAL_RS05020
uniprot id: R4VKN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

1260251:SPISAL RS02220
gene id: 1260251:SPISAL_RS02220
uniprot id: R4V667
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1260251:SPISAL RS06420
gene id: 1260251:SPISAL_RS06420
uniprot id: R4V612
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

1260251:SPISAL RS01675
gene id: 1260251:SPISAL_RS01675
uniprot id: R4V343
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1260251:SPISAL RS04655
gene id: 1260251:SPISAL_RS04655
uniprot id: R4VKG7
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1260251:SPISAL RS01100
gene id: 1260251:SPISAL_RS01100
uniprot id: R4V5J8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1260251:SPISAL RS08590
gene id: 1260251:SPISAL_RS08590
uniprot id: R4V7C4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

1260251:SPISAL RS04225
gene id: 1260251:SPISAL_RS04225
uniprot id: R4VK78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

1260251:SPISAL RS04510
gene id: 1260251:SPISAL_RS04510
uniprot id: R4VN31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1260251:SPISAL RS06565
gene id: 1260251:SPISAL_RS06565
uniprot id: R4VPF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.

1260251:SPISAL RS05700
gene id: 1260251:SPISAL_RS05700
uniprot id: R4VLA3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1260251:SPISAL RS07965
gene id: 1260251:SPISAL_RS07965
uniprot id: R4V6W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Membrane

1260251:SPISAL RS00985
gene id: 1260251:SPISAL_RS00985
uniprot id: R4VI54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1260251:SPISAL RS08155
gene id: 1260251:SPISAL_RS08155
uniprot id: R4VMN5
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS01860
gene id: 1260251:SPISAL_RS01860
uniprot id: R4VDS1
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1260251:SPISAL RS01295
gene id: 1260251:SPISAL_RS01295
uniprot id: R4VL63
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

1260251:SPISAL RS07555
gene id: 1260251:SPISAL_RS07555
uniprot id: R4VMA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1260251:SPISAL RS05135
gene id: 1260251:SPISAL_RS05135
uniprot id: R4V7Y4
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1260251:SPISAL RS01535
gene id: 1260251:SPISAL_RS01535
uniprot id: R4VDJ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1260251:SPISAL RS04460
gene id: 1260251:SPISAL_RS04460
uniprot id: R4VN20
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1260251:SPISAL RS00180
gene id: 1260251:SPISAL_RS00180
uniprot id: R4VKG1
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

1260251:SPISAL RS03130
gene id: 1260251:SPISAL_RS03130
uniprot id: R4VEL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1260251:SPISAL RS00130
gene id: 1260251:SPISAL_RS00130
uniprot id: R4VHN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

1260251:SPISAL RS06900
gene id: 1260251:SPISAL_RS06900
uniprot id: R4VPM5
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

1260251:SPISAL RS01710
gene id: 1260251:SPISAL_RS01710
uniprot id: R4VDN9
names: Similarity
messages: Belongs to the CFA/CMAS family.

1260251:SPISAL RS07610
gene id: 1260251:SPISAL_RS07610
uniprot id: R4VQ45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1260251:SPISAL RS01580
gene id: 1260251:SPISAL_RS01580
uniprot id: R4V5S5
names: Similarity
messages: Belongs to the histone deacetylase family.

1260251:SPISAL RS05235
gene id: 1260251:SPISAL_RS05235
uniprot id: R4V802
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS06840
gene id: 1260251:SPISAL_RS06840
uniprot id: R4VLV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1260251:SPISAL RS00345
gene id: 1260251:SPISAL_RS00345
uniprot id: R4VCV3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

1260251:SPISAL RS08580
gene id: 1260251:SPISAL_RS08580
uniprot id: R4VMY9
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

1260251:SPISAL RS01130
gene id: 1260251:SPISAL_RS01130
uniprot id: R4VDD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

1260251:SPISAL RS00255
gene id: 1260251:SPISAL_RS00255
uniprot id: R4VKH7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1260251:SPISAL RS02120
gene id: 1260251:SPISAL_RS02120
uniprot id: R4V643
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1260251:SPISAL RS03890
gene id: 1260251:SPISAL_RS03890
uniprot id: R4VF21
names: Cofactor
messages: Binds 1 FAD per subunit.

1260251:SPISAL RS05570
gene id: 1260251:SPISAL_RS05570
uniprot id: R4V882
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1260251:SPISAL RS00700
gene id: 1260251:SPISAL_RS00700
uniprot id: R4VD65
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1260251:SPISAL RS04505
gene id: 1260251:SPISAL_RS04505
uniprot id: R4VKD6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

1260251:SPISAL RS00645
gene id: 1260251:SPISAL_RS00645
uniprot id: R4V5C3
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1260251:SPISAL RS01035
gene id: 1260251:SPISAL_RS01035
uniprot id: R4VI64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1260251:SPISAL RS04625
gene id: 1260251:SPISAL_RS04625
uniprot id: R4VFH4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1260251:SPISAL RS02510
gene id: 1260251:SPISAL_RS02510
uniprot id: R4VJ45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

1260251:SPISAL RS04025
gene id: 1260251:SPISAL_RS04025
uniprot id: R4V4K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1260251:SPISAL RS02410
gene id: 1260251:SPISAL_RS02410
uniprot id: R4VJ20
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1260251:SPISAL RS08475
gene id: 1260251:SPISAL_RS08475
uniprot id: R4VHX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS05060
gene id: 1260251:SPISAL_RS05060
uniprot id: R4V7W5
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS00335
gene id: 1260251:SPISAL_RS00335
uniprot id: R4V2A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1260251:SPISAL RS07615
gene id: 1260251:SPISAL_RS07615
uniprot id: R4V6P6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1260251:SPISAL RS02810
gene id: 1260251:SPISAL_RS02810
uniprot id: R4VEE0
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1260251:SPISAL RS05675
gene id: 1260251:SPISAL_RS05675
uniprot id: R4VL89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

1260251:SPISAL RS02110
gene id: 1260251:SPISAL_RS02110
uniprot id: R4VLM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1260251:SPISAL RS06985
gene id: 1260251:SPISAL_RS06985
uniprot id: R4V916
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1260251:SPISAL RS05555
gene id: 1260251:SPISAL_RS05555
uniprot id: R4VG50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1260251:SPISAL RS00380
gene id: 1260251:SPISAL_RS00380
uniprot id: R4VKK3
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1260251:SPISAL RS03085
gene id: 1260251:SPISAL_RS03085
uniprot id: R4VJH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

1260251:SPISAL RS05695
gene id: 1260251:SPISAL_RS05695
uniprot id: R4VG96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1260251:SPISAL RS06750
gene id: 1260251:SPISAL_RS06750
uniprot id: R4V8W8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS04735
gene id: 1260251:SPISAL_RS04735
uniprot id: R4VN74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1260251:SPISAL RS08525
gene id: 1260251:SPISAL_RS08525
uniprot id: R4VHY1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1260251:SPISAL RS07875
gene id: 1260251:SPISAL_RS07875
uniprot id: R4VHI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

1260251:SPISAL RS06635
gene id: 1260251:SPISAL_RS06635
uniprot id: R4VLS0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS02910
gene id: 1260251:SPISAL_RS02910
uniprot id: R4V3U9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

1260251:SPISAL RS03725
gene id: 1260251:SPISAL_RS03725
uniprot id: R4V739
names: Similarity
messages: Belongs to the bacterial secretin family.

1260251:SPISAL RS05840
gene id: 1260251:SPISAL_RS05840
uniprot id: R4VLC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1260251:SPISAL RS03875
gene id: 1260251:SPISAL_RS03875
uniprot id: R4VMQ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AceK family.
messages: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS06575
gene id: 1260251:SPISAL_RS06575
uniprot id: R4V8T3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1260251:SPISAL RS00735
gene id: 1260251:SPISAL_RS00735
uniprot id: R4VKW0
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

1260251:SPISAL RS04830
gene id: 1260251:SPISAL_RS04830
uniprot id: R4VKK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmKL family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.

1260251:SPISAL RS03635
gene id: 1260251:SPISAL_RS03635
uniprot id: R4VJW3
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS01755
gene id: 1260251:SPISAL_RS01755
uniprot id: R4V5W5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS01725
gene id: 1260251:SPISAL_RS01725
uniprot id: R4V352
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

1260251:SPISAL RS08140
gene id: 1260251:SPISAL_RS08140
uniprot id: R4V707
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1260251:SPISAL RS01600
gene id: 1260251:SPISAL_RS01600
uniprot id: R4V327
names: Similarity
messages: Belongs to the YggT family.

1260251:SPISAL RS06905
gene id: 1260251:SPISAL_RS06905
uniprot id: R4V697
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1260251:SPISAL RS07620
gene id: 1260251:SPISAL_RS07620
uniprot id: R4V9F1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1260251:SPISAL RS04515
gene id: 1260251:SPISAL_RS04515
uniprot id: R4V4V1
names: Subcellular Location Annotation
messages: Cytoplasm

1260251:SPISAL RS01040
gene id: 1260251:SPISAL_RS01040
uniprot id: R4VL15
names: Cofactor
names: PTM
names: Subcellular Location Annotation
messages: Binds 2 heme groups per subunit.
messages: Binds 2 heme groups.
messages: Periplasm

1260251:SPISAL RS00745
gene id: 1260251:SPISAL_RS00745
uniprot id: R4V5E1
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS00725
gene id: 1260251:SPISAL_RS00725
uniprot id: R4VD68
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

1260251:SPISAL RS00225
gene id: 1260251:SPISAL_RS00225
uniprot id: R4VHP8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

1260251:SPISAL RS08250
gene id: 1260251:SPISAL_RS08250
uniprot id: R4VHR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

1260251:SPISAL RS02405
gene id: 1260251:SPISAL_RS02405
uniprot id: R4VE33
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS00155
gene id: 1260251:SPISAL_RS00155
uniprot id: R4VKF5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1260251:SPISAL RS02190
gene id: 1260251:SPISAL_RS02190
uniprot id: R4V3F0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1260251:SPISAL RS07350
gene id: 1260251:SPISAL_RS07350
uniprot id: R4VH72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1260251:SPISAL RS07240
gene id: 1260251:SPISAL_RS07240
uniprot id: R4V6G5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1260251:SPISAL RS02770
gene id: 1260251:SPISAL_RS02770
uniprot id: R4VM10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

1260251:SPISAL RS07095
gene id: 1260251:SPISAL_RS07095
uniprot id: R4VM00
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.

1260251:SPISAL RS04570
gene id: 1260251:SPISAL_RS04570
uniprot id: R4V7K6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
messages: Homodimer.

1260251:SPISAL RS00510
gene id: 1260251:SPISAL_RS00510
uniprot id: R4V2E1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1260251:SPISAL RS07190
gene id: 1260251:SPISAL_RS07190
uniprot id: R4V6F3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1260251:SPISAL RS06240
gene id: 1260251:SPISAL_RS06240
uniprot id: R4VP92
names: Function
names: Similarity
messages: Belongs to the ectoine synthase family.
messages: Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.

1260251:SPISAL RS08070
gene id: 1260251:SPISAL_RS08070
uniprot id: R4V9Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1260251:SPISAL RS07640
gene id: 1260251:SPISAL_RS07640
uniprot id: R4V6Q3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1260251:SPISAL RS05420
gene id: 1260251:SPISAL_RS05420
uniprot id: R4VG24
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1260251:SPISAL RS05165
gene id: 1260251:SPISAL_RS05165
uniprot id: R4VFW7
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
messages: Belongs to the RecC family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

1260251:SPISAL RS04710
gene id: 1260251:SPISAL_RS04710
uniprot id: R4VN70
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1260251:SPISAL RS01935
gene id: 1260251:SPISAL_RS01935
uniprot id: R4VDT8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1260251:SPISAL RS03665
gene id: 1260251:SPISAL_RS03665
uniprot id: R4VML8
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

1260251:SPISAL RS07080
gene id: 1260251:SPISAL_RS07080
uniprot id: R4V6D2
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

1260251:SPISAL RS05350
gene id: 1260251:SPISAL_RS05350
uniprot id: R4VNM4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1260251:SPISAL RS07355
gene id: 1260251:SPISAL_RS07355
uniprot id: R4VM52
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1260251:SPISAL RS02625
gene id: 1260251:SPISAL_RS02625
uniprot id: R4V6F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1260251:SPISAL RS08255
gene id: 1260251:SPISAL_RS08255
uniprot id: R4VMS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

1260251:SPISAL RS02140
gene id: 1260251:SPISAL_RS02140
uniprot id: R4V3D7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1260251:SPISAL RS06930
gene id: 1260251:SPISAL_RS06930
uniprot id: R4V6A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

1260251:SPISAL RS05525
gene id: 1260251:SPISAL_RS05525
uniprot id: R4V870
names: Similarity
messages: Belongs to the proline racemase family.

1260251:SPISAL RS03065
gene id: 1260251:SPISAL_RS03065
uniprot id: R4VM74
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.

1260251:SPISAL RS07465
gene id: 1260251:SPISAL_RS07465
uniprot id: R4V6L4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1260251:SPISAL RS06640
gene id: 1260251:SPISAL_RS06640
uniprot id: R4VPH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

1260251:SPISAL RS03045
gene id: 1260251:SPISAL_RS03045
uniprot id: R4V3Z0
names: Similarity
messages: Belongs to the YfgM family.

1260251:SPISAL RS00020
gene id: 1260251:SPISAL_RS00020
uniprot id: R4V4U4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1260251:SPISAL RS04720
gene id: 1260251:SPISAL_RS04720
uniprot id: R4V7N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Brp/Blh beta-carotene diooxygenase family.
messages: Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal.
messages: Cell membrane

1260251:SPISAL RS05170
gene id: 1260251:SPISAL_RS05170
uniprot id: R4VKR9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
messages: Belongs to the helicase family. UvrD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.
messages: The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
messages: The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.

1260251:SPISAL RS05975
gene id: 1260251:SPISAL_RS05975
uniprot id: R4V5T1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the malate synthase family. GlcB subfamily.
messages: Cytoplasm
messages: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1260251:SPISAL RS02150
gene id: 1260251:SPISAL_RS02150
uniprot id: R4VDX9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1260251:SPISAL RS01655
gene id: 1260251:SPISAL_RS01655
uniprot id: R4V5U1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1260251:SPISAL RS05860
gene id: 1260251:SPISAL_RS05860
uniprot id: R4VGC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1260251:SPISAL RS03165
gene id: 1260251:SPISAL_RS03165
uniprot id: R4VJM4
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

1260251:SPISAL RS03600
gene id: 1260251:SPISAL_RS03600
uniprot id: R4VEX1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1260251:SPISAL RS06280
gene id: 1260251:SPISAL_RS06280
uniprot id: R4VGJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the high-potential iron-sulfur protein (HiPIP) family.
messages: Homodimer.
messages: Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria.

1260251:SPISAL RS04185
gene id: 1260251:SPISAL_RS04185
uniprot id: R4V4N7
names: Similarity
messages: Belongs to the peptidase S49 family.

1260251:SPISAL RS01245
gene id: 1260251:SPISAL_RS01245
uniprot id: R4VL54
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1260251:SPISAL RS07625
gene id: 1260251:SPISAL_RS07625
uniprot id: R4VHD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1260251:SPISAL RS06775
gene id: 1260251:SPISAL_RS06775
uniprot id: R4V8X3
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS08015
gene id: 1260251:SPISAL_RS08015
uniprot id: R4V6Y0
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1260251:SPISAL RS04315
gene id: 1260251:SPISAL_RS04315
uniprot id: R4V7F1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

1260251:SPISAL RS01320
gene id: 1260251:SPISAL_RS01320
uniprot id: R4VL67
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1260251:SPISAL RS01125
gene id: 1260251:SPISAL_RS01125
uniprot id: R4V5K3
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1260251:SPISAL RS03430
gene id: 1260251:SPISAL_RS03430
uniprot id: R4V4A6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1260251:SPISAL RS05145
gene id: 1260251:SPISAL_RS05145
uniprot id: R4VKR4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1260251:SPISAL RS08450
gene id: 1260251:SPISAL_RS08450
uniprot id: R4VHX2
names: Similarity
messages: Belongs to the LOG family.

1260251:SPISAL RS02780
gene id: 1260251:SPISAL_RS02780
uniprot id: R4V6J1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

1260251:SPISAL RS06440
gene id: 1260251:SPISAL_RS06440
uniprot id: R4VPD1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1260251:SPISAL RS07100
gene id: 1260251:SPISAL_RS07100
uniprot id: R4VPR8
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1260251:SPISAL RS06965
gene id: 1260251:SPISAL_RS06965
uniprot id: R4VGX9
names: Function
names: Similarity
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.

1260251:SPISAL RS06685
gene id: 1260251:SPISAL_RS06685
uniprot id: R4VLS9
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

1260251:SPISAL RS01250
gene id: 1260251:SPISAL_RS01250
uniprot id: R4V2W7
names: Similarity
messages: Belongs to the AlaDH/PNT family.

1260251:SPISAL RS07230
gene id: 1260251:SPISAL_RS07230
uniprot id: R4VM27
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1260251:SPISAL RS07280
gene id: 1260251:SPISAL_RS07280
uniprot id: R4VM37
names: Similarity
messages: Belongs to the UPF0250 family.

1260251:SPISAL RS02720
gene id: 1260251:SPISAL_RS02720
uniprot id: R4V3Q1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

1260251:SPISAL RS00330
gene id: 1260251:SPISAL_RS00330
uniprot id: R4VKJ4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1260251:SPISAL RS02600
gene id: 1260251:SPISAL_RS02600
uniprot id: R4V6E7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homodimer.

1260251:SPISAL RS04645
gene id: 1260251:SPISAL_RS04645
uniprot id: R4V7M2
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

1260251:SPISAL RS01980
gene id: 1260251:SPISAL_RS01980
uniprot id: R4V615
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS07760
gene id: 1260251:SPISAL_RS07760
uniprot id: R4V6S6
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS05550
gene id: 1260251:SPISAL_RS05550
uniprot id: R4V876
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1260251:SPISAL RS01505
gene id: 1260251:SPISAL_RS01505
uniprot id: R4V5R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS08145
gene id: 1260251:SPISAL_RS08145
uniprot id: R4V9S4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

1260251:SPISAL RS03125
gene id: 1260251:SPISAL_RS03125
uniprot id: R4V6R4
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1260251:SPISAL RS03995
gene id: 1260251:SPISAL_RS03995
uniprot id: R4VMS8
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1260251:SPISAL RS02630
gene id: 1260251:SPISAL_RS02630
uniprot id: R4VE93
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1260251:SPISAL RS02070
gene id: 1260251:SPISAL_RS02070
uniprot id: R4V632
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1260251:SPISAL RS01205
gene id: 1260251:SPISAL_RS01205
uniprot id: R4V5L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS03295
gene id: 1260251:SPISAL_RS03295
uniprot id: R4VJP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1260251:SPISAL RS01470
gene id: 1260251:SPISAL_RS01470
uniprot id: R4VL95
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiC family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.

1260251:SPISAL RS00285
gene id: 1260251:SPISAL_RS00285
uniprot id: R4V289
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

1260251:SPISAL RS07460
gene id: 1260251:SPISAL_RS07460
uniprot id: R4VQ03
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1260251:SPISAL RS07145
gene id: 1260251:SPISAL_RS07145
uniprot id: R4VH21
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1260251:SPISAL RS02350
gene id: 1260251:SPISAL_RS02350
uniprot id: R4V689
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS00690
gene id: 1260251:SPISAL_RS00690
uniprot id: R4V2M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. KdkA/RfaP family.
messages: Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position.
messages: Cell inner membrane
messages: Membrane

1260251:SPISAL RS02710
gene id: 1260251:SPISAL_RS02710
uniprot id: R4VJ83
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1260251:SPISAL RS06885
gene id: 1260251:SPISAL_RS06885
uniprot id: R4V8Z4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1260251:SPISAL RS08190
gene id: 1260251:SPISAL_RS08190
uniprot id: R4V720
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1260251:SPISAL RS05715
gene id: 1260251:SPISAL_RS05715
uniprot id: R4V8D6
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS05320
gene id: 1260251:SPISAL_RS05320
uniprot id: R4VKW4
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1260251:SPISAL RS06890
gene id: 1260251:SPISAL_RS06890
uniprot id: R4VGW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1260251:SPISAL RS01200
gene id: 1260251:SPISAL_RS01200
uniprot id: R4V2V9
names: Similarity
messages: Belongs to the P(II) protein family.

1260251:SPISAL RS03825
gene id: 1260251:SPISAL_RS03825
uniprot id: R4V4G8
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS01380
gene id: 1260251:SPISAL_RS01380
uniprot id: R4V5P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family.
messages: Cell outer membrane
messages: Membrane

1260251:SPISAL RS01430
gene id: 1260251:SPISAL_RS01430
uniprot id: R4V5P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1260251:SPISAL RS01910
gene id: 1260251:SPISAL_RS01910
uniprot id: R4VDT1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1260251:SPISAL RS07150
gene id: 1260251:SPISAL_RS07150
uniprot id: R4VM09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1260251:SPISAL RS04160
gene id: 1260251:SPISAL_RS04160
uniprot id: R4VMV7
names: Similarity
messages: Belongs to the fabD family.

1260251:SPISAL RS04540
gene id: 1260251:SPISAL_RS04540
uniprot id: R4V4V4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

1260251:SPISAL RS01740
gene id: 1260251:SPISAL_RS01740
uniprot id: R4VIM5
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.

1260251:SPISAL RS01345
gene id: 1260251:SPISAL_RS01345
uniprot id: R4VL71
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1260251:SPISAL RS01060
gene id: 1260251:SPISAL_RS01060
uniprot id: R4VI69
names: Similarity
messages: Belongs to the UPF0758 family.

1260251:SPISAL RS02730
gene id: 1260251:SPISAL_RS02730
uniprot id: R4VEC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

1260251:SPISAL RS04820
gene id: 1260251:SPISAL_RS04820
uniprot id: R4V7Q9
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

1260251:SPISAL RS05485
gene id: 1260251:SPISAL_RS05485
uniprot id: R4VNR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS08315
gene id: 1260251:SPISAL_RS08315
uniprot id: R4V778
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

1260251:SPISAL RS05740
gene id: 1260251:SPISAL_RS05740
uniprot id: R4V8D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

1260251:SPISAL RS03185
gene id: 1260251:SPISAL_RS03185
uniprot id: R4VEQ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1260251:SPISAL RS05965
gene id: 1260251:SPISAL_RS05965
uniprot id: R4VLE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1260251:SPISAL RS07975
gene id: 1260251:SPISAL_RS07975
uniprot id: R4VHK3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS07305
gene id: 1260251:SPISAL_RS07305
uniprot id: R4VM41
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
messages: Periplasm
messages: The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

1260251:SPISAL RS05940
gene id: 1260251:SPISAL_RS05940
uniprot id: R4VLE4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS08560
gene id: 1260251:SPISAL_RS08560
uniprot id: R4VQQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1260251:SPISAL RS02605
gene id: 1260251:SPISAL_RS02605
uniprot id: R4VE87
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

1260251:SPISAL RS02685
gene id: 1260251:SPISAL_RS02685
uniprot id: R4VJ76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1260251:SPISAL RS01515
gene id: 1260251:SPISAL_RS01515
uniprot id: R4VIH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane

1260251:SPISAL RS08605
gene id: 1260251:SPISAL_RS08605
uniprot id: R4VMZ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1260251:SPISAL RS02805
gene id: 1260251:SPISAL_RS02805
uniprot id: R4V6J8
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

1260251:SPISAL RS04080
gene id: 1260251:SPISAL_RS04080
uniprot id: R4VK50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

1260251:SPISAL RS02250
gene id: 1260251:SPISAL_RS02250
uniprot id: R4VE00
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1260251:SPISAL RS04235
gene id: 1260251:SPISAL_RS04235
uniprot id: R4V4P7
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS07780
gene id: 1260251:SPISAL_RS07780
uniprot id: R4VQ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane

1260251:SPISAL RS08170
gene id: 1260251:SPISAL_RS08170
uniprot id: R4V9S9
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1260251:SPISAL RS07175
gene id: 1260251:SPISAL_RS07175
uniprot id: R4VH27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolB family.
messages: Cell outer membrane
messages: Membrane
messages: Monomer.
messages: Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.

1260251:SPISAL RS01190
gene id: 1260251:SPISAL_RS01190
uniprot id: R4VI98
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1260251:SPISAL RS00035
gene id: 1260251:SPISAL_RS00035
uniprot id: R4VKC8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1260251:SPISAL RS02745
gene id: 1260251:SPISAL_RS02745
uniprot id: R4V3Q8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

1260251:SPISAL RS02240
gene id: 1260251:SPISAL_RS02240
uniprot id: R4V3G1
names: Similarity
messages: Belongs to the leucine-binding protein family.

1260251:SPISAL RS00370
gene id: 1260251:SPISAL_RS00370
uniprot id: R4VCW0
names: Function
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

1260251:SPISAL RS00980
gene id: 1260251:SPISAL_RS00980
uniprot id: R4VDA9
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS04525
gene id: 1260251:SPISAL_RS04525
uniprot id: R4VFF2
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1260251:SPISAL RS03985
gene id: 1260251:SPISAL_RS03985
uniprot id: R4V783
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1260251:SPISAL RS07925
gene id: 1260251:SPISAL_RS07925
uniprot id: R4VHJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

1260251:SPISAL RS08385
gene id: 1260251:SPISAL_RS08385
uniprot id: R4VQN2
names: Similarity
messages: Belongs to the thioredoxin family.

1260251:SPISAL RS00740
gene id: 1260251:SPISAL_RS00740
uniprot id: R4V2M8
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS02870
gene id: 1260251:SPISAL_RS02870
uniprot id: R4VM31
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1260251:SPISAL RS06355
gene id: 1260251:SPISAL_RS06355
uniprot id: R4VGK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1260251:SPISAL RS03000
gene id: 1260251:SPISAL_RS03000
uniprot id: R4V6N1
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1260251:SPISAL RS02680
gene id: 1260251:SPISAL_RS02680
uniprot id: R4VEA6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1260251:SPISAL RS05400
gene id: 1260251:SPISAL_RS05400
uniprot id: R4VKY7
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.

1260251:SPISAL RS03205
gene id: 1260251:SPISAL_RS03205
uniprot id: R4V6W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

1260251:SPISAL RS00705
gene id: 1260251:SPISAL_RS00705
uniprot id: R4VI06
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

1260251:SPISAL RS06650
gene id: 1260251:SPISAL_RS06650
uniprot id: R4V8U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1260251:SPISAL RS04240
gene id: 1260251:SPISAL_RS04240
uniprot id: R4V7D5
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS04250
gene id: 1260251:SPISAL_RS04250
uniprot id: R4VK83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1260251:SPISAL RS00715
gene id: 1260251:SPISAL_RS00715
uniprot id: R4V2M3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1260251:SPISAL RS04580
gene id: 1260251:SPISAL_RS04580
uniprot id: R4VKF2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS07880
gene id: 1260251:SPISAL_RS07880
uniprot id: R4VMG9
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

1260251:SPISAL RS04165
gene id: 1260251:SPISAL_RS04165
uniprot id: R4V4N2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1260251:SPISAL RS00040
gene id: 1260251:SPISAL_RS00040
uniprot id: R4V233
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1260251:SPISAL RS00135
gene id: 1260251:SPISAL_RS00135
uniprot id: R4VKE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1260251:SPISAL RS02925
gene id: 1260251:SPISAL_RS02925
uniprot id: R4VJC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS00930
gene id: 1260251:SPISAL_RS00930
uniprot id: R4VI43
names: Function
names: Similarity
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.

1260251:SPISAL RS01690
gene id: 1260251:SPISAL_RS01690
uniprot id: R4VIL3
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

1260251:SPISAL RS02380
gene id: 1260251:SPISAL_RS02380
uniprot id: R4VE28
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

1260251:SPISAL RS06405
gene id: 1260251:SPISAL_RS06405
uniprot id: R4VGL2
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

1260251:SPISAL RS06515
gene id: 1260251:SPISAL_RS06515
uniprot id: R4VPE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
messages: Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
messages: Homotetramer.

1260251:SPISAL RS03900
gene id: 1260251:SPISAL_RS03900
uniprot id: R4VMR2
names: Similarity
messages: Belongs to the peptidase M42 family.

1260251:SPISAL RS01455
gene id: 1260251:SPISAL_RS01455
uniprot id: R4V5Q2
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1260251:SPISAL RS06045
gene id: 1260251:SPISAL_RS06045
uniprot id: R4VP60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Homodimer.

1260251:SPISAL RS00295
gene id: 1260251:SPISAL_RS00295
uniprot id: R4VCU0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS06230
gene id: 1260251:SPISAL_RS06230
uniprot id: R4VGI8
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS05055
gene id: 1260251:SPISAL_RS05055
uniprot id: R4V577
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

1260251:SPISAL RS07155
gene id: 1260251:SPISAL_RS07155
uniprot id: R4VPS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1260251:SPISAL RS05005
gene id: 1260251:SPISAL_RS05005
uniprot id: R4V565
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1260251:SPISAL RS04205
gene id: 1260251:SPISAL_RS04205
uniprot id: R4VMW7
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

1260251:SPISAL RS00385
gene id: 1260251:SPISAL_RS00385
uniprot id: R4V2B1
names: Similarity
messages: Belongs to the citrate synthase family.

1260251:SPISAL RS03285
gene id: 1260251:SPISAL_RS03285
uniprot id: R4V6X4
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS04790
gene id: 1260251:SPISAL_RS04790
uniprot id: R4V512
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1260251:SPISAL RS03485
gene id: 1260251:SPISAL_RS03485
uniprot id: R4V704
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS03405
gene id: 1260251:SPISAL_RS03405
uniprot id: R4V4A2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1260251:SPISAL RS04770
gene id: 1260251:SPISAL_RS04770
uniprot id: R4V7P8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1260251:SPISAL RS08205
gene id: 1260251:SPISAL_RS08205
uniprot id: R4VMP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-2 integral membrane protein family. Lipooligosaccharide exporter (TC 3.A.1.102) subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction. Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4-linked N-acetylglucosamine oligosaccharide. This subunit encodes the transporter.
messages: The complex is composed of two ATP-binding proteins (NodI) and two transmembrane proteins (NodJ).

1260251:SPISAL RS07940
gene id: 1260251:SPISAL_RS07940
uniprot id: R4V6W1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

1260251:SPISAL RS07045
gene id: 1260251:SPISAL_RS07045
uniprot id: R4VLZ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS01635
gene id: 1260251:SPISAL_RS01635
uniprot id: R4VDM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1260251:SPISAL RS05460
gene id: 1260251:SPISAL_RS05460
uniprot id: R4V5G7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1260251:SPISAL RS00450
gene id: 1260251:SPISAL_RS00450
uniprot id: R4VHU3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1260251:SPISAL RS05270
gene id: 1260251:SPISAL_RS05270
uniprot id: R4VKU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

1260251:SPISAL RS00070
gene id: 1260251:SPISAL_RS00070
uniprot id: R4V4V3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

1260251:SPISAL RS00470
gene id: 1260251:SPISAL_RS00470
uniprot id: R4VCY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS07590
gene id: 1260251:SPISAL_RS07590
uniprot id: R4V6P0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1260251:SPISAL RS08435
gene id: 1260251:SPISAL_RS08435
uniprot id: R4VQN8
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

1260251:SPISAL RS01460
gene id: 1260251:SPISAL_RS01460
uniprot id: R4VDI3
names: Similarity
messages: Belongs to the RutC family.

1260251:SPISAL RS03980
gene id: 1260251:SPISAL_RS03980
uniprot id: R4V4J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS05285
gene id: 1260251:SPISAL_RS05285
uniprot id: R4V813
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1260251:SPISAL RS06220
gene id: 1260251:SPISAL_RS06220
uniprot id: R4V5X4
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

1260251:SPISAL RS05000
gene id: 1260251:SPISAL_RS05000
uniprot id: R4VND7
names: Similarity
messages: Belongs to the SufE family.

1260251:SPISAL RS00945
gene id: 1260251:SPISAL_RS00945
uniprot id: R4V5H5
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

1260251:SPISAL RS03700
gene id: 1260251:SPISAL_RS03700
uniprot id: R4V736
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1260251:SPISAL RS07170
gene id: 1260251:SPISAL_RS07170
uniprot id: R4V954
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

1260251:SPISAL RS03275
gene id: 1260251:SPISAL_RS03275
uniprot id: R4VME9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1260251:SPISAL RS04610
gene id: 1260251:SPISAL_RS04610
uniprot id: R4VN51
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

1260251:SPISAL RS02325
gene id: 1260251:SPISAL_RS02325
uniprot id: R4V686
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1260251:SPISAL RS06255
gene id: 1260251:SPISAL_RS06255
uniprot id: R4VGJ2
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

1260251:SPISAL RS02695
gene id: 1260251:SPISAL_RS02695
uniprot id: R4V3P7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS03040
gene id: 1260251:SPISAL_RS03040
uniprot id: R4VM69
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1260251:SPISAL RS02420
gene id: 1260251:SPISAL_RS02420
uniprot id: R4V3J7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1260251:SPISAL RS07395
gene id: 1260251:SPISAL_RS07395
uniprot id: R4V999
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1260251:SPISAL RS06500
gene id: 1260251:SPISAL_RS06500
uniprot id: R4V8R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1260251:SPISAL RS02920
gene id: 1260251:SPISAL_RS02920
uniprot id: R4VEG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1260251:SPISAL RS07850
gene id: 1260251:SPISAL_RS07850
uniprot id: R4VHH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1260251:SPISAL RS04105
gene id: 1260251:SPISAL_RS04105
uniprot id: R4VK55
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1260251:SPISAL RS08725
gene id: 1260251:SPISAL_RS08725
uniprot id: R4VQM8
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS08115
gene id: 1260251:SPISAL_RS08115
uniprot id: R4V702
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1260251:SPISAL RS01340
gene id: 1260251:SPISAL_RS01340
uniprot id: R4VID2
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1260251:SPISAL RS06330
gene id: 1260251:SPISAL_RS06330
uniprot id: R4VGK1
names: Similarity
messages: Belongs to the transglycosylase Slt family.

1260251:SPISAL RS08535
gene id: 1260251:SPISAL_RS08535
uniprot id: R4VQQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1260251:SPISAL RS07450
gene id: 1260251:SPISAL_RS07450
uniprot id: R4VH94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1260251:SPISAL RS01115
gene id: 1260251:SPISAL_RS01115
uniprot id: R4VL29
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmJ family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the guanosine in position 1516 of 16S rRNA.

1260251:SPISAL RS06815
gene id: 1260251:SPISAL_RS06815
uniprot id: R4VLV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

1260251:SPISAL RS02735
gene id: 1260251:SPISAL_RS02735
uniprot id: R4VJ88
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

1260251:SPISAL RS02115
gene id: 1260251:SPISAL_RS02115
uniprot id: R4V3D2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

1260251:SPISAL RS08445
gene id: 1260251:SPISAL_RS08445
uniprot id: R4VA03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

1260251:SPISAL RS07485
gene id: 1260251:SPISAL_RS07485
uniprot id: R4VQ10
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1260251:SPISAL RS02585
gene id: 1260251:SPISAL_RS02585
uniprot id: R4VJ60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1260251:SPISAL RS04500
gene id: 1260251:SPISAL_RS04500
uniprot id: R4VFE5
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS01055
gene id: 1260251:SPISAL_RS01055
uniprot id: R4VDC2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS01165
gene id: 1260251:SPISAL_RS01165
uniprot id: R4VL40
names: Similarity
messages: Belongs to the histone deacetylase family.

1260251:SPISAL RS04630
gene id: 1260251:SPISAL_RS04630
uniprot id: R4VKG2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1260251:SPISAL RS03440
gene id: 1260251:SPISAL_RS03440
uniprot id: R4VEU7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

1260251:SPISAL RS07980
gene id: 1260251:SPISAL_RS07980
uniprot id: R4VMJ4
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

1260251:SPISAL RS06435
gene id: 1260251:SPISAL_RS06435
uniprot id: R4VLN3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1260251:SPISAL RS08915
gene id: 1260251:SPISAL_RS08915
uniprot id: R4V9Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

1260251:SPISAL RS05315
gene id: 1260251:SPISAL_RS05315
uniprot id: R4VG01
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.

1260251:SPISAL RS03135
gene id: 1260251:SPISAL_RS03135
uniprot id: R4VJK9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1260251:SPISAL RS00420
gene id: 1260251:SPISAL_RS00420
uniprot id: R4VCX4
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS02180
gene id: 1260251:SPISAL_RS02180
uniprot id: R4VIX0
names: Similarity
messages: Belongs to the PhoH family.

1260251:SPISAL RS06570
gene id: 1260251:SPISAL_RS06570
uniprot id: R4V639
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

1260251:SPISAL RS07550
gene id: 1260251:SPISAL_RS07550
uniprot id: R4VHB8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1260251:SPISAL RS02990
gene id: 1260251:SPISAL_RS02990
uniprot id: R4VM55
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1260251:SPISAL RS02700
gene id: 1260251:SPISAL_RS02700
uniprot id: R4V6H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

1260251:SPISAL RS06015
gene id: 1260251:SPISAL_RS06015
uniprot id: R4VLF6
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1260251:SPISAL RS01565
gene id: 1260251:SPISAL_RS01565
uniprot id: R4VII4
names: Similarity
messages: Belongs to the SCO1/2 family.

1260251:SPISAL RS05110
gene id: 1260251:SPISAL_RS05110
uniprot id: R4V7X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

1260251:SPISAL RS02575
gene id: 1260251:SPISAL_RS02575
uniprot id: R4V6E2
names: Caution
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS08550
gene id: 1260251:SPISAL_RS08550
uniprot id: R4VHY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1260251:SPISAL RS08375
gene id: 1260251:SPISAL_RS08375
uniprot id: R4VHW1
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

1260251:SPISAL RS05630
gene id: 1260251:SPISAL_RS05630
uniprot id: R4VL51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

1260251:SPISAL RS02820
gene id: 1260251:SPISAL_RS02820
uniprot id: R4VM25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1260251:SPISAL RS08425
gene id: 1260251:SPISAL_RS08425
uniprot id: R4VHW8
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS02595
gene id: 1260251:SPISAL_RS02595
uniprot id: R4V3N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1260251:SPISAL RS08380
gene id: 1260251:SPISAL_RS08380
uniprot id: R4VMV6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS04640
gene id: 1260251:SPISAL_RS04640
uniprot id: R4V4X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1260251:SPISAL RS05075
gene id: 1260251:SPISAL_RS05075
uniprot id: R4VNF7
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1260251:SPISAL RS01080
gene id: 1260251:SPISAL_RS01080
uniprot id: R4VDC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

1260251:SPISAL RS05640
gene id: 1260251:SPISAL_RS05640
uniprot id: R4V5L3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.
messages: The heme is bound between the two transmembrane subunits.

1260251:SPISAL RS04430
gene id: 1260251:SPISAL_RS04430
uniprot id: R4VKB9
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

1260251:SPISAL RS05625
gene id: 1260251:SPISAL_RS05625
uniprot id: R4VG64
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

1260251:SPISAL RS06110
gene id: 1260251:SPISAL_RS06110
uniprot id: R4VGG8
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

1260251:SPISAL RS07135
gene id: 1260251:SPISAL_RS07135
uniprot id: R4V949
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1260251:SPISAL RS00275
gene id: 1260251:SPISAL_RS00275
uniprot id: R4VHQ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1260251:SPISAL RS02550
gene id: 1260251:SPISAL_RS02550
uniprot id: R4V6D5
names: Similarity
messages: Belongs to the WrbA family.

1260251:SPISAL RS00415
gene id: 1260251:SPISAL_RS00415
uniprot id: R4V548
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS00545
gene id: 1260251:SPISAL_RS00545
uniprot id: R4V578
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1260251:SPISAL RS04730
gene id: 1260251:SPISAL_RS04730
uniprot id: R4VKI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1260251:SPISAL RS06760
gene id: 1260251:SPISAL_RS06760
uniprot id: R4VLU3
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS07315
gene id: 1260251:SPISAL_RS07315
uniprot id: R4V6I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1260251:SPISAL RS01625
gene id: 1260251:SPISAL_RS01625
uniprot id: R4V332
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1260251:SPISAL RS06735
gene id: 1260251:SPISAL_RS06735
uniprot id: R4VLT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS07645
gene id: 1260251:SPISAL_RS07645
uniprot id: R4V9F9
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1260251:SPISAL RS04925
gene id: 1260251:SPISAL_RS04925
uniprot id: R4VNC0
names: Similarity
messages: Belongs to the YoeB family.

1260251:SPISAL RS04085
gene id: 1260251:SPISAL_RS04085
uniprot id: R4VMU2
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

1260251:SPISAL RS01275
gene id: 1260251:SPISAL_RS01275
uniprot id: R4V2X0
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1260251:SPISAL RS05545
gene id: 1260251:SPISAL_RS05545
uniprot id: R4V5I6
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1260251:SPISAL RS05200
gene id: 1260251:SPISAL_RS05200
uniprot id: R4VNI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CopC family.
messages: Involved in copper resistance.
messages: Periplasm

1260251:SPISAL RS07600
gene id: 1260251:SPISAL_RS07600
uniprot id: R4VHD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1260251:SPISAL RS02265
gene id: 1260251:SPISAL_RS02265
uniprot id: R4V3G6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1260251:SPISAL RS06415
gene id: 1260251:SPISAL_RS06415
uniprot id: R4VPC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

1260251:SPISAL RS08600
gene id: 1260251:SPISAL_RS08600
uniprot id: R4VHY9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS00580
gene id: 1260251:SPISAL_RS00580
uniprot id: R4VHY8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS07415
gene id: 1260251:SPISAL_RS07415
uniprot id: R4V6K3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1260251:SPISAL RS07025
gene id: 1260251:SPISAL_RS07025
uniprot id: R4VPQ3
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1260251:SPISAL RS03775
gene id: 1260251:SPISAL_RS03775
uniprot id: R4V4F9
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS06425
gene id: 1260251:SPISAL_RS06425
uniprot id: R4V8Q0
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1260251:SPISAL RS05160
gene id: 1260251:SPISAL_RS05160
uniprot id: R4V7Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS03390
gene id: 1260251:SPISAL_RS03390
uniprot id: R4VEU0
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

1260251:SPISAL RS00115
gene id: 1260251:SPISAL_RS00115
uniprot id: R4V249
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

1260251:SPISAL RS04975
gene id: 1260251:SPISAL_RS04975
uniprot id: R4VND2
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1260251:SPISAL RS01085
gene id: 1260251:SPISAL_RS01085
uniprot id: R4VI76
names: Similarity
messages: Belongs to the peptidase M16 family.

1260251:SPISAL RS03675
gene id: 1260251:SPISAL_RS03675
uniprot id: R4V732
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.

1260251:SPISAL RS04270
gene id: 1260251:SPISAL_RS04270
uniprot id: R4VF99
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS00565
gene id: 1260251:SPISAL_RS00565
uniprot id: R4V2I0
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

1260251:SPISAL RS02580
gene id: 1260251:SPISAL_RS02580
uniprot id: R4VE79
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1260251:SPISAL RS07500
gene id: 1260251:SPISAL_RS07500
uniprot id: R4VHA6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1260251:SPISAL RS02975
gene id: 1260251:SPISAL_RS02975
uniprot id: R4V6M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane

1260251:SPISAL RS08575
gene id: 1260251:SPISAL_RS08575
uniprot id: R4VHY7
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS01270
gene id: 1260251:SPISAL_RS01270
uniprot id: R4VL59
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiD family.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
messages: Cell membrane
messages: Homohexamer.

1260251:SPISAL RS03020
gene id: 1260251:SPISAL_RS03020
uniprot id: R4V3Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1260251:SPISAL RS02665
gene id: 1260251:SPISAL_RS02665
uniprot id: R4VLY8
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

1260251:SPISAL RS06410
gene id: 1260251:SPISAL_RS06410
uniprot id: R4VLM9
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

1260251:SPISAL RS05900
gene id: 1260251:SPISAL_RS05900
uniprot id: R4V5R8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolA family.
messages: Monomer.
messages: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
messages: Periplasm

1260251:SPISAL RS07795
gene id: 1260251:SPISAL_RS07795
uniprot id: R4V9J1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1260251:SPISAL RS08090
gene id: 1260251:SPISAL_RS08090
uniprot id: R4V6Z7
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

1260251:SPISAL RS01760
gene id: 1260251:SPISAL_RS01760
uniprot id: R4VDP9
names: Similarity
messages: Belongs to the TrpC family.

1260251:SPISAL RS01095
gene id: 1260251:SPISAL_RS01095
uniprot id: R4V2U0
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmD family.
messages: Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle.

1260251:SPISAL RS08460
gene id: 1260251:SPISAL_RS08460
uniprot id: R4VQP2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1260251:SPISAL RS07830
gene id: 1260251:SPISAL_RS07830
uniprot id: R4VMF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1260251:SPISAL RS03150
gene id: 1260251:SPISAL_RS03150
uniprot id: R4V444
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1260251:SPISAL RS06615
gene id: 1260251:SPISAL_RS06615
uniprot id: R4VPG9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.
messages: May be beta-lysylated on the epsilon-amino group of Lys-34 by the combined action of EpmA and EpmB, and then hydroxylated on the C5 position of the same residue by EpmC (if this protein is present). Lysylation is critical for the stimulatory effect of EF-P on peptide-bond formation. The lysylation moiety may extend toward the peptidyltransferase center and stabilize the terminal 3-CCA end of the tRNA. Hydroxylation of the C5 position on Lys-34 may allow additional potential stabilizing hydrogen-bond interactions with the P-tRNA.

1260251:SPISAL RS01135
gene id: 1260251:SPISAL_RS01135
uniprot id: R4VI86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RdgC family.
messages: May be involved in recombination.
messages: nucleoid

1260251:SPISAL RS03780
gene id: 1260251:SPISAL_RS03780
uniprot id: R4V747
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS03605
gene id: 1260251:SPISAL_RS03605
uniprot id: R4VJV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

1260251:SPISAL RS06560
gene id: 1260251:SPISAL_RS06560
uniprot id: R4VLQ7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS07515
gene id: 1260251:SPISAL_RS07515
uniprot id: R4V6M5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1260251:SPISAL RS05945
gene id: 1260251:SPISAL_RS05945
uniprot id: R4VP43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HflD family.
messages: Cell membrane
messages: Cytoplasm

1260251:SPISAL RS01260
gene id: 1260251:SPISAL_RS01260
uniprot id: R4VDF4
names: Similarity
messages: Belongs to the MlaA family.

1260251:SPISAL RS04365
gene id: 1260251:SPISAL_RS04365
uniprot id: R4V7G2
names: Similarity
messages: Belongs to the YkuD family.

1260251:SPISAL RS05120
gene id: 1260251:SPISAL_RS05120
uniprot id: R4VKQ8
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS01640
gene id: 1260251:SPISAL_RS01640
uniprot id: R4VIK0
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

1260251:SPISAL RS00455
gene id: 1260251:SPISAL_RS00455
uniprot id: R4VKL8
names: Cofactor
messages: Can also use Mn(2+) ion.

1260251:SPISAL RS00015
gene id: 1260251:SPISAL_RS00015
uniprot id: R4V226
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1260251:SPISAL RS01155
gene id: 1260251:SPISAL_RS01155
uniprot id: R4VDD7
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

1260251:SPISAL RS05745
gene id: 1260251:SPISAL_RS05745
uniprot id: R4VGB2
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

1260251:SPISAL RS03470
gene id: 1260251:SPISAL_RS03470
uniprot id: R4VJT3
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1260251:SPISAL RS03410
gene id: 1260251:SPISAL_RS03410
uniprot id: R4V6Z4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS01500
gene id: 1260251:SPISAL_RS01500
uniprot id: R4V313
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

1260251:SPISAL RS08355
gene id: 1260251:SPISAL_RS08355
uniprot id: R4VMV1
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm
messages: In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.

1260251:SPISAL RS04650
gene id: 1260251:SPISAL_RS04650
uniprot id: R4VFI0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS03515
gene id: 1260251:SPISAL_RS03515
uniprot id: R4VEW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

1260251:SPISAL RS04555
gene id: 1260251:SPISAL_RS04555
uniprot id: R4VKE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1260251:SPISAL RS08540
gene id: 1260251:SPISAL_RS08540
uniprot id: R4V7B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1260251:SPISAL RS00490
gene id: 1260251:SPISAL_RS00490
uniprot id: R4V566
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

1260251:SPISAL RS03535
gene id: 1260251:SPISAL_RS03535
uniprot id: R4V4C4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1260251:SPISAL RS05905
gene id: 1260251:SPISAL_RS05905
uniprot id: R4V8F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Membrane

1260251:SPISAL RS01030
gene id: 1260251:SPISAL_RS01030
uniprot id: R4VDB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

1260251:SPISAL RS07270
gene id: 1260251:SPISAL_RS07270
uniprot id: R4V975
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RlpA family.
messages: Cell membrane
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

1260251:SPISAL RS01025
gene id: 1260251:SPISAL_RS01025
uniprot id: R4V5I5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

1260251:SPISAL RS06720
gene id: 1260251:SPISAL_RS06720
uniprot id: R4V668
names: Function
messages: Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals.

1260251:SPISAL RS06525
gene id: 1260251:SPISAL_RS06525
uniprot id: R4V8S2
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS00635
gene id: 1260251:SPISAL_RS00635
uniprot id: R4VKT9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1260251:SPISAL RS00170
gene id: 1260251:SPISAL_RS00170
uniprot id: R4VCQ9
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Involved in a late step of protoheme IX synthesis.
messages: Membrane

1260251:SPISAL RS00950
gene id: 1260251:SPISAL_RS00950
uniprot id: R4VDA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

1260251:SPISAL RS08570
gene id: 1260251:SPISAL_RS08570
uniprot id: R4VA22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1260251:SPISAL RS01315
gene id: 1260251:SPISAL_RS01315
uniprot id: R4VIC5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1260251:SPISAL RS05875
gene id: 1260251:SPISAL_RS05875
uniprot id: R4V5R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1260251:SPISAL RS03095
gene id: 1260251:SPISAL_RS03095
uniprot id: R4V405
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1260251:SPISAL RS07410
gene id: 1260251:SPISAL_RS07410
uniprot id: R4VPY8
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

1260251:SPISAL RS07580
gene id: 1260251:SPISAL_RS07580
uniprot id: R4VMA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1260251:SPISAL RS05650
gene id: 1260251:SPISAL_RS05650
uniprot id: R4VL58
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1260251:SPISAL RS03500
gene id: 1260251:SPISAL_RS03500
uniprot id: R4VMJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1260251:SPISAL RS01195
gene id: 1260251:SPISAL_RS01195
uniprot id: R4VL44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiK family.
messages: Cytoplasm
messages: Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.

1260251:SPISAL RS00595
gene id: 1260251:SPISAL_RS00595
uniprot id: R4V5B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS01950
gene id: 1260251:SPISAL_RS01950
uniprot id: R4V3A1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1260251:SPISAL RS04345
gene id: 1260251:SPISAL_RS04345
uniprot id: R4VFB1
names: Function
names: Similarity
messages: Belongs to the Dus family. DusA subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.

1260251:SPISAL RS01440
gene id: 1260251:SPISAL_RS01440
uniprot id: R4VIF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1260251:SPISAL RS01335
gene id: 1260251:SPISAL_RS01335
uniprot id: R4VDG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

1260251:SPISAL RS01970
gene id: 1260251:SPISAL_RS01970
uniprot id: R4VLK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

1260251:SPISAL RS02815
gene id: 1260251:SPISAL_RS02815
uniprot id: R4VJA6
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1260251:SPISAL RS06520
gene id: 1260251:SPISAL_RS06520
uniprot id: R4V631
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS06100
gene id: 1260251:SPISAL_RS06100
uniprot id: R4V5V3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1260251:SPISAL RS01665
gene id: 1260251:SPISAL_RS01665
uniprot id: R4VIK7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

1260251:SPISAL RS05885
gene id: 1260251:SPISAL_RS05885
uniprot id: R4VGD3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS03305
gene id: 1260251:SPISAL_RS03305
uniprot id: R4V485
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

1260251:SPISAL RS01920
gene id: 1260251:SPISAL_RS01920
uniprot id: R4VLJ1
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS06445
gene id: 1260251:SPISAL_RS06445
uniprot id: R4V617
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1260251:SPISAL RS06910
gene id: 1260251:SPISAL_RS06910
uniprot id: R4V8Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

1260251:SPISAL RS02590
gene id: 1260251:SPISAL_RS02590
uniprot id: R4VLX3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS07635
gene id: 1260251:SPISAL_RS07635
uniprot id: R4VQ51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1260251:SPISAL RS07225
gene id: 1260251:SPISAL_RS07225
uniprot id: R4VH40
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1260251:SPISAL RS01735
gene id: 1260251:SPISAL_RS01735
uniprot id: R4VDP4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1260251:SPISAL RS00390
gene id: 1260251:SPISAL_RS00390
uniprot id: R4V540
names: Similarity
messages: Belongs to the PrpD family.

1260251:SPISAL RS00045
gene id: 1260251:SPISAL_RS00045
uniprot id: R4V4U9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

1260251:SPISAL RS03230
gene id: 1260251:SPISAL_RS03230
uniprot id: R4V470
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1260251:SPISAL RS00005
gene id: 1260251:SPISAL_RS00005
uniprot id: R4VHK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1260251:SPISAL RS06915
gene id: 1260251:SPISAL_RS06915
uniprot id: R4VGW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsQ/DivIB family. FtsQ subfamily.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

1260251:SPISAL RS06705
gene id: 1260251:SPISAL_RS06705
uniprot id: R4VGR9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1260251:SPISAL RS07495
gene id: 1260251:SPISAL_RS07495
uniprot id: R4V9B9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1260251:SPISAL RS00340
gene id: 1260251:SPISAL_RS00340
uniprot id: R4V526
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1260251:SPISAL RS03250
gene id: 1260251:SPISAL_RS03250
uniprot id: R4VME4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1260251:SPISAL RS08555
gene id: 1260251:SPISAL_RS08555
uniprot id: R4VMY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1260251:SPISAL RS04635
gene id: 1260251:SPISAL_RS04635
uniprot id: R4VN55
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1260251:SPISAL RS00620
gene id: 1260251:SPISAL_RS00620
uniprot id: R4V5B8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.

1260251:SPISAL RS03180
gene id: 1260251:SPISAL_RS03180
uniprot id: R4V6V3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

1260251:SPISAL RS06645
gene id: 1260251:SPISAL_RS06645
uniprot id: R4V655
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family. ParE type 1 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

1260251:SPISAL RS04255
gene id: 1260251:SPISAL_RS04255
uniprot id: R4VMX8
names: Similarity
messages: Belongs to the SfsA family.

1260251:SPISAL RS06820
gene id: 1260251:SPISAL_RS06820
uniprot id: R4VPK7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1260251:SPISAL RS06380
gene id: 1260251:SPISAL_RS06380
uniprot id: R4VGK8
names: Function
names: Subunit
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.

1260251:SPISAL RS07855
gene id: 1260251:SPISAL_RS07855
uniprot id: R4VMG2
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS01045
gene id: 1260251:SPISAL_RS01045
uniprot id: R4V2T0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1260251:SPISAL RS08370
gene id: 1260251:SPISAL_RS08370
uniprot id: R4V9Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1260251:SPISAL RS08545
gene id: 1260251:SPISAL_RS08545
uniprot id: R4VA19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1260251:SPISAL RS04495
gene id: 1260251:SPISAL_RS04495
uniprot id: R4V7I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

1260251:SPISAL RS04795
gene id: 1260251:SPISAL_RS04795
uniprot id: R4V7Q4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1260251:SPISAL RS07235
gene id: 1260251:SPISAL_RS07235
uniprot id: R4VPU2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1260251:SPISAL RS06975
gene id: 1260251:SPISAL_RS06975
uniprot id: R4VPP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1260251:SPISAL RS06335
gene id: 1260251:SPISAL_RS06335
uniprot id: R4VLL6
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS04290
gene id: 1260251:SPISAL_RS04290
uniprot id: R4V7E5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Homodimer.

1260251:SPISAL RS02750
gene id: 1260251:SPISAL_RS02750
uniprot id: R4V6I6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1260251:SPISAL RS04260
gene id: 1260251:SPISAL_RS04260
uniprot id: R4V4Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1260251:SPISAL RS01670
gene id: 1260251:SPISAL_RS01670
uniprot id: R4VLD5
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1260251:SPISAL RS03315
gene id: 1260251:SPISAL_RS03315
uniprot id: R4VES9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZipA family.
messages: Cell inner membrane
messages: Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.
messages: Interacts with FtsZ via their C-terminal domains.

1260251:SPISAL RS05355
gene id: 1260251:SPISAL_RS05355
uniprot id: R4V5E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS01550
gene id: 1260251:SPISAL_RS01550
uniprot id: R4V320
names: Similarity
messages: Belongs to the peptidase S49 family.

1260251:SPISAL RS02095
gene id: 1260251:SPISAL_RS02095
uniprot id: R4V638
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TolB family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: Periplasm
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1260251:SPISAL RS01610
gene id: 1260251:SPISAL_RS01610
uniprot id: R4VDL5
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1260251:SPISAL RS04380
gene id: 1260251:SPISAL_RS04380
uniprot id: R4VN04
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.
messages: Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids.

1260251:SPISAL RS04810
gene id: 1260251:SPISAL_RS04810
uniprot id: R4VN91
names: Function
names: Subunit
messages: Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins.
messages: Homodimer.

1260251:SPISAL RS08300
gene id: 1260251:SPISAL_RS08300
uniprot id: R4VHU9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1260251:SPISAL RS07320
gene id: 1260251:SPISAL_RS07320
uniprot id: R4V983
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

1260251:SPISAL RS07455
gene id: 1260251:SPISAL_RS07455
uniprot id: R4VM77
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1260251:SPISAL RS01560
gene id: 1260251:SPISAL_RS01560
uniprot id: R4VDK5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS00100
gene id: 1260251:SPISAL_RS00100
uniprot id: R4VCP3
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

1260251:SPISAL RS05430
gene id: 1260251:SPISAL_RS05430
uniprot id: R4VNP6
names: Similarity
messages: Belongs to the GcvT family.

1260251:SPISAL RS04575
gene id: 1260251:SPISAL_RS04575
uniprot id: R4VFG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1260251:SPISAL RS04595
gene id: 1260251:SPISAL_RS04595
uniprot id: R4V7L1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1260251:SPISAL RS00055
gene id: 1260251:SPISAL_RS00055
uniprot id: R4VHL9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.

1260251:SPISAL RS07565
gene id: 1260251:SPISAL_RS07565
uniprot id: R4V6N4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1260251:SPISAL RS02465
gene id: 1260251:SPISAL_RS02465
uniprot id: R4VLV0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

1260251:SPISAL RS07200
gene id: 1260251:SPISAL_RS07200
uniprot id: R4VH32
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

1260251:SPISAL RS04680
gene id: 1260251:SPISAL_RS04680
uniprot id: R4VKH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1260251:SPISAL RS02105
gene id: 1260251:SPISAL_RS02105
uniprot id: R4VIV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1260251:SPISAL RS07480
gene id: 1260251:SPISAL_RS07480
uniprot id: R4VM84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1260251:SPISAL RS08900
gene id: 1260251:SPISAL_RS08900
uniprot id: R4VP09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1260251:SPISAL RS07605
gene id: 1260251:SPISAL_RS07605
uniprot id: R4VMB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1260251:SPISAL RS00145
gene id: 1260251:SPISAL_RS00145
uniprot id: R4VCQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

1260251:SPISAL RS08595
gene id: 1260251:SPISAL_RS08595
uniprot id: R4VA26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

1260251:SPISAL RS06980
gene id: 1260251:SPISAL_RS06980
uniprot id: R4V6B0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1260251:SPISAL RS07020
gene id: 1260251:SPISAL_RS07020
uniprot id: R4VLY6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

1260251:SPISAL RS01400
gene id: 1260251:SPISAL_RS01400
uniprot id: R4V2Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

1260251:SPISAL RS02090
gene id: 1260251:SPISAL_RS02090
uniprot id: R4V3C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Cell outer membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1260251:SPISAL RS06545
gene id: 1260251:SPISAL_RS06545
uniprot id: R4V636
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1260251:SPISAL RS01660
gene id: 1260251:SPISAL_RS01660
uniprot id: R4VDM7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

1260251:SPISAL RS07945
gene id: 1260251:SPISAL_RS07945
uniprot id: R4V9M7
names: Similarity
messages: Belongs to the CFA/CMAS family.

1260251:SPISAL RS01475
gene id: 1260251:SPISAL_RS01475
uniprot id: R4V308
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
messages: Cell inner membrane

1260251:SPISAL RS07365
gene id: 1260251:SPISAL_RS07365
uniprot id: R4V6J3
names: Similarity
messages: Belongs to the DNA polymerase HolA subunit family.

1260251:SPISAL RS01855
gene id: 1260251:SPISAL_RS01855
uniprot id: R4V5Y6
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.

1260251:SPISAL RS06855
gene id: 1260251:SPISAL_RS06855
uniprot id: R4V691
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP E family.
messages: Cytoplasm

1260251:SPISAL RS01825
gene id: 1260251:SPISAL_RS01825
uniprot id: R4VLH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1260251:SPISAL RS00625
gene id: 1260251:SPISAL_RS00625
uniprot id: R4VD51
names: Similarity
messages: Belongs to the CutA family.

1260251:SPISAL RS02435
gene id: 1260251:SPISAL_RS02435
uniprot id: R4VJ26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TamA family.
messages: Cell outer membrane
messages: Membrane

1260251:SPISAL RS08390
gene id: 1260251:SPISAL_RS08390
uniprot id: R4V791
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

1260251:SPISAL RS04155
gene id: 1260251:SPISAL_RS04155
uniprot id: R4VK63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

1260251:SPISAL RS05935
gene id: 1260251:SPISAL_RS05935
uniprot id: R4VGE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

1260251:SPISAL RS03240
gene id: 1260251:SPISAL_RS03240
uniprot id: R4VER4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1260251:SPISAL RS03160
gene id: 1260251:SPISAL_RS03160
uniprot id: R4VEP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1260251:SPISAL RS06080
gene id: 1260251:SPISAL_RS06080
uniprot id: R4V8H5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Homotrimer.

1260251:SPISAL RS03310
gene id: 1260251:SPISAL_RS03310
uniprot id: R4V6X8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1260251:SPISAL RS00375
gene id: 1260251:SPISAL_RS00375
uniprot id: R4VHS7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

1260251:SPISAL RS06620
gene id: 1260251:SPISAL_RS06620
uniprot id: R4V649
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

1260251:SPISAL RS02455
gene id: 1260251:SPISAL_RS02455
uniprot id: R4VE45
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase T family.
messages: Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.

1260251:SPISAL RS03080
gene id: 1260251:SPISAL_RS03080
uniprot id: R4VEK2
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1260251:SPISAL RS05045
gene id: 1260251:SPISAL_RS05045
uniprot id: R4VKP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Brp/Blh beta-carotene diooxygenase family.
messages: Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal.
messages: Cell membrane

1260251:SPISAL RS06315
gene id: 1260251:SPISAL_RS06315
uniprot id: R4VPA7
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

1260251:SPISAL RS01410
gene id: 1260251:SPISAL_RS01410
uniprot id: R4VDH3
names: Similarity
messages: Belongs to the citrate synthase family.

1260251:SPISAL RS07475
gene id: 1260251:SPISAL_RS07475
uniprot id: R4VHA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1260251:SPISAL RS04930
gene id: 1260251:SPISAL_RS04930
uniprot id: R4V549
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1260251:SPISAL RS03235
gene id: 1260251:SPISAL_RS03235
uniprot id: R4V6W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1260251:SPISAL RS02440
gene id: 1260251:SPISAL_RS02440
uniprot id: R4VLU6
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS02425
gene id: 1260251:SPISAL_RS02425
uniprot id: R4V6A5
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

1260251:SPISAL RS07440
gene id: 1260251:SPISAL_RS07440
uniprot id: R4V6K8
names: Caution
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS06810
gene id: 1260251:SPISAL_RS06810
uniprot id: R4VGU2
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

1260251:SPISAL RS03945
gene id: 1260251:SPISAL_RS03945
uniprot id: R4VK25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS00110
gene id: 1260251:SPISAL_RS00110
uniprot id: R4VKE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

1260251:SPISAL RS06590
gene id: 1260251:SPISAL_RS06590
uniprot id: R4VPG3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

1260251:SPISAL RS07185
gene id: 1260251:SPISAL_RS07185
uniprot id: R4VPT5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1260251:SPISAL RS00250
gene id: 1260251:SPISAL_RS00250
uniprot id: R4VHQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family. TsaC subfamily.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.

1260251:SPISAL RS05565
gene id: 1260251:SPISAL_RS05565
uniprot id: R4V5J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

1260251:SPISAL RS00310
gene id: 1260251:SPISAL_RS00310
uniprot id: R4V295
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

1260251:SPISAL RS05370
gene id: 1260251:SPISAL_RS05370
uniprot id: R4VKY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1260251:SPISAL RS03870
gene id: 1260251:SPISAL_RS03870
uniprot id: R4VK10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1260251:SPISAL RS04760
gene id: 1260251:SPISAL_RS04760
uniprot id: R4VN79
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1260251:SPISAL RS01015
gene id: 1260251:SPISAL_RS01015
uniprot id: R4VL11
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1260251:SPISAL RS07575
gene id: 1260251:SPISAL_RS07575
uniprot id: R4VHC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1260251:SPISAL RS05890
gene id: 1260251:SPISAL_RS05890
uniprot id: R4VLD4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1260251:SPISAL RS02610
gene id: 1260251:SPISAL_RS02610
uniprot id: R4VJ64
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS03555
gene id: 1260251:SPISAL_RS03555
uniprot id: R4VMK0
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

1260251:SPISAL RS03400
gene id: 1260251:SPISAL_RS03400
uniprot id: R4VMH3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1260251:SPISAL RS05810
gene id: 1260251:SPISAL_RS05810
uniprot id: R4VGC0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1260251:SPISAL RS05635
gene id: 1260251:SPISAL_RS05635
uniprot id: R4VNV5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.

1260251:SPISAL RS08185
gene id: 1260251:SPISAL_RS08185
uniprot id: R4VQH9
names: Similarity
messages: Belongs to the universal stress protein A family.

1260251:SPISAL RS06995
gene id: 1260251:SPISAL_RS06995
uniprot id: R4VLY1
names: Similarity
messages: Belongs to the UPF0102 family.

1260251:SPISAL RS05685
gene id: 1260251:SPISAL_RS05685
uniprot id: R4V5P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1260251:SPISAL RS03590
gene id: 1260251:SPISAL_RS03590
uniprot id: R4V4D2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1260251:SPISAL RS05845
gene id: 1260251:SPISAL_RS05845
uniprot id: R4VP25
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1260251:SPISAL RS08100
gene id: 1260251:SPISAL_RS08100
uniprot id: R4VHN2
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

1260251:SPISAL RS01880
gene id: 1260251:SPISAL_RS01880
uniprot id: R4V5Z4
names: Similarity
messages: Belongs to the universal stress protein A family.

1260251:SPISAL RS04590
gene id: 1260251:SPISAL_RS04590
uniprot id: R4V4W4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1260251:SPISAL RS06935
gene id: 1260251:SPISAL_RS06935
uniprot id: R4V904
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

1260251:SPISAL RS00785
gene id: 1260251:SPISAL_RS00785
uniprot id: R4VKW8
names: Function
names: Similarity
messages: Belongs to the CsgG family.
messages: May be involved in the biogenesis of curli organelles.

1260251:SPISAL RS07895
gene id: 1260251:SPISAL_RS07895
uniprot id: R4V9L4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

1260251:SPISAL RS02155
gene id: 1260251:SPISAL_RS02155
uniprot id: R4VIW4
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1260251:SPISAL RS05080
gene id: 1260251:SPISAL_RS05080
uniprot id: R4V581
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

1260251:SPISAL RS06455
gene id: 1260251:SPISAL_RS06455
uniprot id: R4VGM1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1260251:SPISAL RS02890
gene id: 1260251:SPISAL_RS02890
uniprot id: R4VJB5
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1260251:SPISAL RS04995
gene id: 1260251:SPISAL_RS04995
uniprot id: R4VKN1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1260251:SPISAL RS04685
gene id: 1260251:SPISAL_RS04685
uniprot id: R4VN66
names: Similarity
messages: Belongs to the PhoH family.

1260251:SPISAL RS08270
gene id: 1260251:SPISAL_RS08270
uniprot id: R4V9X7
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1260251:SPISAL RS04785
gene id: 1260251:SPISAL_RS04785
uniprot id: R4VN84
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1260251:SPISAL RS07595
gene id: 1260251:SPISAL_RS07595
uniprot id: R4V9E5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1260251:SPISAL RS01570
gene id: 1260251:SPISAL_RS01570
uniprot id: R4VLB4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1260251:SPISAL RS00560
gene id: 1260251:SPISAL_RS00560
uniprot id: R4VKR1
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

1260251:SPISAL RS06755
gene id: 1260251:SPISAL_RS06755
uniprot id: R4VGS8
names: Subcellular Location Annotation
messages: Membrane

1260251:SPISAL RS07510
gene id: 1260251:SPISAL_RS07510
uniprot id: R4VQ18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1260251:SPISAL RS04195
gene id: 1260251:SPISAL_RS04195
uniprot id: R4VF84
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.