1247726:MIM RS19220
gene id: 1247726:MIM_RS19220
uniprot id: W0PFB2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

1247726:MIM RS07980
gene id: 1247726:MIM_RS07980
uniprot id: W0PDR4
names: Similarity
messages: Belongs to the ArsC family.

1247726:MIM RS09270
gene id: 1247726:MIM_RS09270
uniprot id: W0PAT4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1247726:MIM RS02530
gene id: 1247726:MIM_RS02530
uniprot id: W0PAR4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1247726:MIM RS21570
gene id: 1247726:MIM_RS21570
uniprot id: W0PGC6
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS17140
gene id: 1247726:MIM_RS17140
uniprot id: W0PHR6
names: Similarity
messages: Belongs to the asparagine synthetase family.

1247726:MIM RS09955
gene id: 1247726:MIM_RS09955
uniprot id: W0PB64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1247726:MIM RS05240
gene id: 1247726:MIM_RS05240
uniprot id: W0PDJ2
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

1247726:MIM RS05070
gene id: 1247726:MIM_RS05070
uniprot id: W0P8L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

1247726:MIM RS09900
gene id: 1247726:MIM_RS09900
uniprot id: W0PB53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RlmJ family.
messages: Monomer.
messages: Specifically methylates the adenine in position 2030 of 23S rRNA.

1247726:MIM RS06420
gene id: 1247726:MIM_RS06420
uniprot id: W0P8Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS10790
gene id: 1247726:MIM_RS10790
uniprot id: W0PB87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS18880
gene id: 1247726:MIM_RS18880
uniprot id: W0PG03
names: Similarity
messages: Belongs to the VgrG protein family.

1247726:MIM RS20320
gene id: 1247726:MIM_RS20320
uniprot id: W0PK20
names: Similarity
messages: Belongs to the bacterial PQQ dehydrogenase family.

1247726:MIM RS18255
gene id: 1247726:MIM_RS18255
uniprot id: W0PI75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS15650
gene id: 1247726:MIM_RS15650
uniprot id: W0PDU1
names: Function
messages: May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.

1247726:MIM RS04200
gene id: 1247726:MIM_RS04200
uniprot id: W0P7S8
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS09630
gene id: 1247726:MIM_RS09630
uniprot id: W0PAN5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1247726:MIM RS02565
gene id: 1247726:MIM_RS02565
uniprot id: W0P6U8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1247726:MIM RS12130
gene id: 1247726:MIM_RS12130
uniprot id: W0PFV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cdh family.
messages: Membrane

1247726:MIM RS20860
gene id: 1247726:MIM_RS20860
uniprot id: W0PJ09
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1247726:MIM RS09960
gene id: 1247726:MIM_RS09960
uniprot id: W0PEM4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1247726:MIM RS11135
gene id: 1247726:MIM_RS11135
uniprot id: W0PBX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

1247726:MIM RS07795
gene id: 1247726:MIM_RS07795
uniprot id: W0PA02
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1247726:MIM RS07950
gene id: 1247726:MIM_RS07950
uniprot id: W0PA31
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group II subfamily.

1247726:MIM RS16200
gene id: 1247726:MIM_RS16200
uniprot id: W0PH20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1247726:MIM RS20105
gene id: 1247726:MIM_RS20105
uniprot id: W0PLJ8
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS12555
gene id: 1247726:MIM_RS12555
uniprot id: W0PGP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

1247726:MIM RS02760
gene id: 1247726:MIM_RS02760
uniprot id: W0PAV8
names: Subcellular Location Annotation
messages: Mitochondrion

1247726:MIM RS03720
gene id: 1247726:MIM_RS03720
uniprot id: W0PCR1
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS05020
gene id: 1247726:MIM_RS05020
uniprot id: W0P8K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

1247726:MIM RS11055
gene id: 1247726:MIM_RS11055
uniprot id: W0PGE1
names: Similarity
messages: Belongs to the OsmC/Ohr family.

1247726:MIM RS09010
gene id: 1247726:MIM_RS09010
uniprot id: W0PAC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS17360
gene id: 1247726:MIM_RS17360
uniprot id: W0PIN4
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS11980
gene id: 1247726:MIM_RS11980
uniprot id: W0PHC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

1247726:MIM RS09750
gene id: 1247726:MIM_RS09750
uniprot id: W0PFU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

1247726:MIM RS16460
gene id: 1247726:MIM_RS16460
uniprot id: W0PJP5
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

1247726:MIM RS10945
gene id: 1247726:MIM_RS10945
uniprot id: W0PBC0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1247726:MIM RS07230
gene id: 1247726:MIM_RS07230
uniprot id: W0PDB5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.

1247726:MIM RS01285
gene id: 1247726:MIM_RS01285
uniprot id: W0PAB2
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

1247726:MIM RS19015
gene id: 1247726:MIM_RS19015
uniprot id: W0PF63
names: Function
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

1247726:MIM RS01860
gene id: 1247726:MIM_RS01860
uniprot id: W0PAL4
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1247726:MIM RS19005
gene id: 1247726:MIM_RS19005
uniprot id: W0PID6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS19045
gene id: 1247726:MIM_RS19045
uniprot id: W0PJA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS01010
gene id: 1247726:MIM_RS01010
uniprot id: W0P609
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1247726:MIM RS02795
gene id: 1247726:MIM_RS02795
uniprot id: W0P6Z5
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.

1247726:MIM RS03945
gene id: 1247726:MIM_RS03945
uniprot id: W0PCU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. UvrD subfamily.
messages: Homodimer.
messages: Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.

1247726:MIM RS14055
gene id: 1247726:MIM_RS14055
uniprot id: W0PGG9
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1247726:MIM RS05985
gene id: 1247726:MIM_RS05985
uniprot id: W0PCU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS02730
gene id: 1247726:MIM_RS02730
uniprot id: W0P7A5
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS06315
gene id: 1247726:MIM_RS06315
uniprot id: W0PE45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS00790
gene id: 1247726:MIM_RS00790
uniprot id: W0P690
names: Function
names: Similarity
messages: Belongs to the SsuD family.
messages: Catalyzes the desulfonation of aliphatic sulfonates.

1247726:MIM RS12800
gene id: 1247726:MIM_RS12800
uniprot id: W0PG54
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS03210
gene id: 1247726:MIM_RS03210
uniprot id: W0PBD3
names: Subcellular Location Annotation
messages: Periplasm

1247726:MIM RS04540
gene id: 1247726:MIM_RS04540
uniprot id: W0P7Y9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate across the membrane.

1247726:MIM RS00415
gene id: 1247726:MIM_RS00415
uniprot id: W0P9W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS20585
gene id: 1247726:MIM_RS20585
uniprot id: W0PK65
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1247726:MIM RS12885
gene id: 1247726:MIM_RS12885
uniprot id: W0PCC7
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

1247726:MIM RS19115
gene id: 1247726:MIM_RS19115
uniprot id: W0PF79
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1247726:MIM RS06245
gene id: 1247726:MIM_RS06245
uniprot id: W0PCZ9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1247726:MIM RS20930
gene id: 1247726:MIM_RS20930
uniprot id: W0PHM8
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

1247726:MIM RS12600
gene id: 1247726:MIM_RS12600
uniprot id: W0PC79
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrQ family.
messages: Binds 1 FMN per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Membrane
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.

1247726:MIM RS12425
gene id: 1247726:MIM_RS12425
uniprot id: W0PC37
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS11195
gene id: 1247726:MIM_RS11195
uniprot id: W0PH21
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiC family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.

1247726:MIM RS05160
gene id: 1247726:MIM_RS05160
uniprot id: W0PC80
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1247726:MIM RS02540
gene id: 1247726:MIM_RS02540
uniprot id: W0P6U1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1247726:MIM RS20600
gene id: 1247726:MIM_RS20600
uniprot id: W0PLR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1247726:MIM RS04335
gene id: 1247726:MIM_RS04335
uniprot id: W0P7V1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1247726:MIM RS10620
gene id: 1247726:MIM_RS10620
uniprot id: W0PEY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS03555
gene id: 1247726:MIM_RS03555
uniprot id: W0PBJ8
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

1247726:MIM RS13505
gene id: 1247726:MIM_RS13505
uniprot id: W0PI86
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

1247726:MIM RS07475
gene id: 1247726:MIM_RS07475
uniprot id: W0P9U3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1247726:MIM RS20770
gene id: 1247726:MIM_RS20770
uniprot id: W0PHI4
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS05410
gene id: 1247726:MIM_RS05410
uniprot id: W0PCI5
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

1247726:MIM RS05775
gene id: 1247726:MIM_RS05775
uniprot id: W0PCL4
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

1247726:MIM RS17895
gene id: 1247726:MIM_RS17895
uniprot id: W0PIT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS07310
gene id: 1247726:MIM_RS07310
uniprot id: W0PEI6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1247726:MIM RS17180
gene id: 1247726:MIM_RS17180
uniprot id: W0PEH5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
messages: Cell membrane

1247726:MIM RS07580
gene id: 1247726:MIM_RS07580
uniprot id: W0PDN2
names: Similarity
messages: Belongs to the phosphoribulokinase family.

1247726:MIM RS15590
gene id: 1247726:MIM_RS15590
uniprot id: W0PJ34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1247726:MIM RS20810
gene id: 1247726:MIM_RS20810
uniprot id: W0PIZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS20685
gene id: 1247726:MIM_RS20685
uniprot id: W0PK86
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1247726:MIM RS02350
gene id: 1247726:MIM_RS02350
uniprot id: W0P718
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS20580
gene id: 1247726:MIM_RS20580
uniprot id: W0PFZ8
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1247726:MIM RS12675
gene id: 1247726:MIM_RS12675
uniprot id: W0PHQ6
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1247726:MIM RS15945
gene id: 1247726:MIM_RS15945
uniprot id: W0PJC6
names: Similarity
messages: Belongs to the ArsC family.

1247726:MIM RS02145
gene id: 1247726:MIM_RS02145
uniprot id: W0P6X6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1247726:MIM RS09555
gene id: 1247726:MIM_RS09555
uniprot id: W0PAM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1247726:MIM RS19165
gene id: 1247726:MIM_RS19165
uniprot id: W0PFA5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS13225
gene id: 1247726:MIM_RS13225
uniprot id: W0PCH5
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1247726:MIM RS08505
gene id: 1247726:MIM_RS08505
uniprot id: W0PAH0
names: Similarity
messages: Belongs to the UPF0178 family.

1247726:MIM RS09160
gene id: 1247726:MIM_RS09160
uniprot id: W0PEW5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS10770
gene id: 1247726:MIM_RS10770
uniprot id: W0PFR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS14010
gene id: 1247726:MIM_RS14010
uniprot id: W0PIH9
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
messages: Periplasm
messages: The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

1247726:MIM RS12500
gene id: 1247726:MIM_RS12500
uniprot id: W0PC54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1247726:MIM RS04090
gene id: 1247726:MIM_RS04090
uniprot id: W0PBN0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS03855
gene id: 1247726:MIM_RS03855
uniprot id: W0PBQ6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1247726:MIM RS10740
gene id: 1247726:MIM_RS10740
uniprot id: W0PB79
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1247726:MIM RS11315
gene id: 1247726:MIM_RS11315
uniprot id: W0PC06
names: Similarity
messages: Belongs to the YjdM family.

1247726:MIM RS00145
gene id: 1247726:MIM_RS00145
uniprot id: W0P9F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS15030
gene id: 1247726:MIM_RS15030
uniprot id: W0PGQ8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

1247726:MIM RS13750
gene id: 1247726:MIM_RS13750
uniprot id: W0PCV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS07490
gene id: 1247726:MIM_RS07490
uniprot id: W0PEL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell inner membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

1247726:MIM RS05285
gene id: 1247726:MIM_RS05285
uniprot id: W0PCA7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1247726:MIM RS07550
gene id: 1247726:MIM_RS07550
uniprot id: W0P9I4
names: Function
names: Similarity
messages: Belongs to the PqqB family.
messages: May be involved in the transport of PQQ or its precursor to the periplasm.

1247726:MIM RS10165
gene id: 1247726:MIM_RS10165
uniprot id: W0PG10
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1247726:MIM RS01720
gene id: 1247726:MIM_RS01720
uniprot id: W0PAB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AceK family.
messages: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
messages: Cytoplasm

1247726:MIM RS16475
gene id: 1247726:MIM_RS16475
uniprot id: W0PEY3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS06705
gene id: 1247726:MIM_RS06705
uniprot id: W0PD66
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS11240
gene id: 1247726:MIM_RS11240
uniprot id: W0PFF7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1247726:MIM RS07685
gene id: 1247726:MIM_RS07685
uniprot id: W0PDQ1
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS06330
gene id: 1247726:MIM_RS06330
uniprot id: W0P9A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS19555
gene id: 1247726:MIM_RS19555
uniprot id: W0PLA0
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

1247726:MIM RS19670
gene id: 1247726:MIM_RS19670
uniprot id: W0PJP8
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.

1247726:MIM RS01725
gene id: 1247726:MIM_RS01725
uniprot id: W0PBK7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS18690
gene id: 1247726:MIM_RS18690
uniprot id: W0PIB9
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS21280
gene id: 1247726:MIM_RS21280
uniprot id: W0PM47
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

1247726:MIM RS00900
gene id: 1247726:MIM_RS00900
uniprot id: W0P9W2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS12575
gene id: 1247726:MIM_RS12575
uniprot id: W0PC74
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1247726:MIM RS14700
gene id: 1247726:MIM_RS14700
uniprot id: W0PDP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

1247726:MIM RS11265
gene id: 1247726:MIM_RS11265
uniprot id: W0PFF8
names: Similarity
messages: Belongs to the IMPACT family.

1247726:MIM RS12250
gene id: 1247726:MIM_RS12250
uniprot id: W0PCE5
names: Similarity
messages: Belongs to the GARS family.

1247726:MIM RS16735
gene id: 1247726:MIM_RS16735
uniprot id: W0PII6
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1247726:MIM RS00170
gene id: 1247726:MIM_RS00170
uniprot id: W0P9G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS13715
gene id: 1247726:MIM_RS13715
uniprot id: W0PGF1
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1247726:MIM RS06200
gene id: 1247726:MIM_RS06200
uniprot id: W0PCS1
names: Cofactor
messages: Binds 1 Mg(2+) ion per subunit.

1247726:MIM RS09410
gene id: 1247726:MIM_RS09410
uniprot id: W0PF05
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1247726:MIM RS09475
gene id: 1247726:MIM_RS09475
uniprot id: W0PFN8
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

1247726:MIM RS15455
gene id: 1247726:MIM_RS15455
uniprot id: W0PGT6
names: Similarity
messages: Belongs to the YggT family.

1247726:MIM RS16210
gene id: 1247726:MIM_RS16210
uniprot id: W0PE41
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

1247726:MIM RS01415
gene id: 1247726:MIM_RS01415
uniprot id: W0P6K1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase S45 family.
messages: Binds 1 Ca(2+) ion per dimer.

1247726:MIM RS09945
gene id: 1247726:MIM_RS09945
uniprot id: W0PAU3
names: Similarity
messages: Belongs to the pirin family.

1247726:MIM RS15645
gene id: 1247726:MIM_RS15645
uniprot id: W0PJ45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aromatic amine dehydrogenase light chain family.
messages: Heterotetramer of two light and two heavy chains.
messages: Methylamine dehydrogenase carries out the oxidation of methylamine. Electrons are passed from methylamine dehydrogenase to amicyanin.
messages: Periplasm

1247726:MIM RS20595
gene id: 1247726:MIM_RS20595
uniprot id: W0PIW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1247726:MIM RS10380
gene id: 1247726:MIM_RS10380
uniprot id: W0PFI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS12400
gene id: 1247726:MIM_RS12400
uniprot id: W0PGN4
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS08645
gene id: 1247726:MIM_RS08645
uniprot id: W0PEP4
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.

1247726:MIM RS01810
gene id: 1247726:MIM_RS01810
uniprot id: W0PAK4
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1247726:MIM RS16380
gene id: 1247726:MIM_RS16380
uniprot id: W0PHB9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1247726:MIM RS19615
gene id: 1247726:MIM_RS19615
uniprot id: W0PFJ1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1247726:MIM RS09020
gene id: 1247726:MIM_RS09020
uniprot id: W0PAP7
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS06375
gene id: 1247726:MIM_RS06375
uniprot id: W0PD18
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS09360
gene id: 1247726:MIM_RS09360
uniprot id: W0PF03
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS21385
gene id: 1247726:MIM_RS21385
uniprot id: W0PM65
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

1247726:MIM RS21610
gene id: 1247726:MIM_RS21610
uniprot id: W0PJD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS11305
gene id: 1247726:MIM_RS11305
uniprot id: W0PGH0
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS08380
gene id: 1247726:MIM_RS08380
uniprot id: W0PDX9
names: Function
names: Similarity
messages: Belongs to the ClpA/ClpB family.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.

1247726:MIM RS19390
gene id: 1247726:MIM_RS19390
uniprot id: W0PGY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS17300
gene id: 1247726:MIM_RS17300
uniprot id: W0PK35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS11025
gene id: 1247726:MIM_RS11025
uniprot id: W0PBF2
names: Similarity
messages: Belongs to the Gfa family.

1247726:MIM RS20480
gene id: 1247726:MIM_RS20480
uniprot id: W0PK44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS15605
gene id: 1247726:MIM_RS15605
uniprot id: W0PE30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

1247726:MIM RS03290
gene id: 1247726:MIM_RS03290
uniprot id: W0PBE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS13240
gene id: 1247726:MIM_RS13240
uniprot id: W0PGA0
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

1247726:MIM RS18780
gene id: 1247726:MIM_RS18780
uniprot id: W0PKT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS10375
gene id: 1247726:MIM_RS10375
uniprot id: W0PB09
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1247726:MIM RS11460
gene id: 1247726:MIM_RS11460
uniprot id: W0PH57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

1247726:MIM RS19500
gene id: 1247726:MIM_RS19500
uniprot id: W0PII4
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS18765
gene id: 1247726:MIM_RS18765
uniprot id: W0PJ48
names: Similarity
messages: Belongs to the class-A beta-lactamase family.

1247726:MIM RS19870
gene id: 1247726:MIM_RS19870
uniprot id: W0PLF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS15365
gene id: 1247726:MIM_RS15365
uniprot id: W0PHR7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1247726:MIM RS07220
gene id: 1247726:MIM_RS07220
uniprot id: W0PDG2
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS20625
gene id: 1247726:MIM_RS20625
uniprot id: W0PLS4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1247726:MIM RS14665
gene id: 1247726:MIM_RS14665
uniprot id: W0PDB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS09600
gene id: 1247726:MIM_RS09600
uniprot id: W0PFR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

1247726:MIM RS15380
gene id: 1247726:MIM_RS15380
uniprot id: W0PIZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1247726:MIM RS15475
gene id: 1247726:MIM_RS15475
uniprot id: W0PE08
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1247726:MIM RS12180
gene id: 1247726:MIM_RS12180
uniprot id: W0PFW0
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

1247726:MIM RS10610
gene id: 1247726:MIM_RS10610
uniprot id: W0PFN1
names: Similarity
messages: Belongs to the PrpD family.

1247726:MIM RS19890
gene id: 1247726:MIM_RS19890
uniprot id: W0PIP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS01760
gene id: 1247726:MIM_RS01760
uniprot id: W0PAJ5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS07105
gene id: 1247726:MIM_RS07105
uniprot id: W0PEF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS08225
gene id: 1247726:MIM_RS08225
uniprot id: W0PDZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
messages: Cytoplasm
messages: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.

1247726:MIM RS09590
gene id: 1247726:MIM_RS09590
uniprot id: W0PAZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RdgC family.
messages: May be involved in recombination.
messages: nucleoid

1247726:MIM RS13495
gene id: 1247726:MIM_RS13495
uniprot id: W0PCZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS20155
gene id: 1247726:MIM_RS20155
uniprot id: W0PLK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1247726:MIM RS14005
gene id: 1247726:MIM_RS14005
uniprot id: W0PGG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1247726:MIM RS09345
gene id: 1247726:MIM_RS09345
uniprot id: W0PAU9
names: Similarity
messages: Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.

1247726:MIM RS13105
gene id: 1247726:MIM_RS13105
uniprot id: W0PI08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS03770
gene id: 1247726:MIM_RS03770
uniprot id: W0PCR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

1247726:MIM RS13630
gene id: 1247726:MIM_RS13630
uniprot id: W0PGY5
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

1247726:MIM RS02130
gene id: 1247726:MIM_RS02130
uniprot id: W0PBT1
names: Similarity
messages: Belongs to the bacterial PQQ dehydrogenase family.

1247726:MIM RS15570
gene id: 1247726:MIM_RS15570
uniprot id: W0PDS5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS18975
gene id: 1247726:MIM_RS18975
uniprot id: W0PG17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Aromatic acid:H(+) symporter (AAHS) (TC 2.A.1.15) family.
messages: Membrane

1247726:MIM RS04315
gene id: 1247726:MIM_RS04315
uniprot id: W0PBY5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1247726:MIM RS10225
gene id: 1247726:MIM_RS10225
uniprot id: W0PFE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1247726:MIM RS12170
gene id: 1247726:MIM_RS12170
uniprot id: W0PGM1
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

1247726:MIM RS03885
gene id: 1247726:MIM_RS03885
uniprot id: W0P804
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1247726:MIM RS14225
gene id: 1247726:MIM_RS14225
uniprot id: W0PH68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS02185
gene id: 1247726:MIM_RS02185
uniprot id: W0P6M1
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS02975
gene id: 1247726:MIM_RS02975
uniprot id: W0P734
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS20910
gene id: 1247726:MIM_RS20910
uniprot id: W0PJ17
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

1247726:MIM RS08440
gene id: 1247726:MIM_RS08440
uniprot id: W0PA33
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

1247726:MIM RS08675
gene id: 1247726:MIM_RS08675
uniprot id: W0PA70
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1247726:MIM RS20315
gene id: 1247726:MIM_RS20315
uniprot id: W0PFW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS15390
gene id: 1247726:MIM_RS15390
uniprot id: W0PHR9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 1 iron-sulfur cluster per subunit.
messages: Homodimer.
messages: Required for insertion of 4Fe-4S clusters.

1247726:MIM RS15560
gene id: 1247726:MIM_RS15560
uniprot id: W0PGU4
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

1247726:MIM RS10000
gene id: 1247726:MIM_RS10000
uniprot id: W0PFA1
names: Similarity
messages: Belongs to the RutC family.

1247726:MIM RS14245
gene id: 1247726:MIM_RS14245
uniprot id: W0PD42
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS14660
gene id: 1247726:MIM_RS14660
uniprot id: W0PIR0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS20850
gene id: 1247726:MIM_RS20850
uniprot id: R4JQ65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1247726:MIM RS20935
gene id: 1247726:MIM_RS20935
uniprot id: W0PJ21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1247726:MIM RS06055
gene id: 1247726:MIM_RS06055
uniprot id: W0P8S7
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1247726:MIM RS21120
gene id: 1247726:MIM_RS21120
uniprot id: W0PJ49
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

1247726:MIM RS11565
gene id: 1247726:MIM_RS11565
uniprot id: W0PH69
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

1247726:MIM RS12355
gene id: 1247726:MIM_RS12355
uniprot id: W0PCG0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS20660
gene id: 1247726:MIM_RS20660
uniprot id: W0PK80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1247726:MIM RS19895
gene id: 1247726:MIM_RS19895
uniprot id: W0PLG2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1247726:MIM RS07450
gene id: 1247726:MIM_RS07450
uniprot id: W0P9T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1247726:MIM RS10965
gene id: 1247726:MIM_RS10965
uniprot id: W0PF46
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS15470
gene id: 1247726:MIM_RS15470
uniprot id: W0PHS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

1247726:MIM RS11215
gene id: 1247726:MIM_RS11215
uniprot id: W0PFF2
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.

1247726:MIM RS12495
gene id: 1247726:MIM_RS12495
uniprot id: W0PHL2
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1247726:MIM RS19885
gene id: 1247726:MIM_RS19885
uniprot id: W0PH47
names: Similarity
messages: Belongs to the UxaA family.

1247726:MIM RS02330
gene id: 1247726:MIM_RS02330
uniprot id: W0PAM3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1247726:MIM RS12895
gene id: 1247726:MIM_RS12895
uniprot id: W0PCQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1247726:MIM RS07075
gene id: 1247726:MIM_RS07075
uniprot id: W0PD81
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1247726:MIM RS03650
gene id: 1247726:MIM_RS03650
uniprot id: W0P7I2
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS09170
gene id: 1247726:MIM_RS09170
uniprot id: W0PEB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS09965
gene id: 1247726:MIM_RS09965
uniprot id: W0PFX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1247726:MIM RS20410
gene id: 1247726:MIM_RS20410
uniprot id: W0PLP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1247726:MIM RS07200
gene id: 1247726:MIM_RS07200
uniprot id: W0P9P0
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.
messages: Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids.

1247726:MIM RS13090
gene id: 1247726:MIM_RS13090
uniprot id: W0PGT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS11670
gene id: 1247726:MIM_RS11670
uniprot id: W0PBR1
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

1247726:MIM RS16910
gene id: 1247726:MIM_RS16910
uniprot id: W0PEE0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1247726:MIM RS14050
gene id: 1247726:MIM_RS14050
uniprot id: W0PDD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

1247726:MIM RS14965
gene id: 1247726:MIM_RS14965
uniprot id: W0PDH0
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

1247726:MIM RS11810
gene id: 1247726:MIM_RS11810
uniprot id: W0PC81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.
messages: Cell surface

1247726:MIM RS15840
gene id: 1247726:MIM_RS15840
uniprot id: W0PGW6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.

1247726:MIM RS02375
gene id: 1247726:MIM_RS02375
uniprot id: W0P725
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

1247726:MIM RS07970
gene id: 1247726:MIM_RS07970
uniprot id: W0PDV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS13725
gene id: 1247726:MIM_RS13725
uniprot id: W0PCU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1247726:MIM RS01985
gene id: 1247726:MIM_RS01985
uniprot id: W0PAF7
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1247726:MIM RS21470
gene id: 1247726:MIM_RS21470
uniprot id: W0PKN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1247726:MIM RS02625
gene id: 1247726:MIM_RS02625
uniprot id: W0PB04
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

1247726:MIM RS07785
gene id: 1247726:MIM_RS07785
uniprot id: W0P9M8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

1247726:MIM RS10485
gene id: 1247726:MIM_RS10485
uniprot id: W0PBF9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1247726:MIM RS09205
gene id: 1247726:MIM_RS09205
uniprot id: W0PFJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS12510
gene id: 1247726:MIM_RS12510
uniprot id: W0PCI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1247726:MIM RS12565
gene id: 1247726:MIM_RS12565
uniprot id: W0PG34
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1247726:MIM RS01475
gene id: 1247726:MIM_RS01475
uniprot id: W0PBG0
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS18335
gene id: 1247726:MIM_RS18335
uniprot id: W0PI87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS08135
gene id: 1247726:MIM_RS08135
uniprot id: W0PDT3
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS08370
gene id: 1247726:MIM_RS08370
uniprot id: W0PE13
names: Subcellular Location Annotation
messages: Cytoplasm

1247726:MIM RS18250
gene id: 1247726:MIM_RS18250
uniprot id: W0PFR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS04785
gene id: 1247726:MIM_RS04785
uniprot id: W0PC78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1247726:MIM RS06145
gene id: 1247726:MIM_RS06145
uniprot id: W0P977
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

1247726:MIM RS17490
gene id: 1247726:MIM_RS17490
uniprot id: W0PEK8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

1247726:MIM RS02545
gene id: 1247726:MIM_RS02545
uniprot id: W0PAZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1247726:MIM RS20505
gene id: 1247726:MIM_RS20505
uniprot id: W0PK50
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1247726:MIM RS16490
gene id: 1247726:MIM_RS16490
uniprot id: W0PE97
names: Similarity
messages: Belongs to the cysteine dioxygenase family.

1247726:MIM RS11595
gene id: 1247726:MIM_RS11595
uniprot id: W0PBP8
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS06795
gene id: 1247726:MIM_RS06795
uniprot id: W0PEB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1247726:MIM RS08825
gene id: 1247726:MIM_RS08825
uniprot id: W0PA96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1247726:MIM RS07225
gene id: 1247726:MIM_RS07225
uniprot id: W0P9P6
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

1247726:MIM RS06125
gene id: 1247726:MIM_RS06125
uniprot id: W0PCQ8
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1247726:MIM RS21150
gene id: 1247726:MIM_RS21150
uniprot id: W0PM19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS10385
gene id: 1247726:MIM_RS10385
uniprot id: W0PBE2
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

1247726:MIM RS04830
gene id: 1247726:MIM_RS04830
uniprot id: W0P838
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1247726:MIM RS08750
gene id: 1247726:MIM_RS08750
uniprot id: W0PA84
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS10085
gene id: 1247726:MIM_RS10085
uniprot id: W0PEP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1247726:MIM RS05085
gene id: 1247726:MIM_RS05085
uniprot id: W0P889
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

1247726:MIM RS12020
gene id: 1247726:MIM_RS12020
uniprot id: W0PCB2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1247726:MIM RS00935
gene id: 1247726:MIM_RS00935
uniprot id: W0P5Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

1247726:MIM RS15050
gene id: 1247726:MIM_RS15050
uniprot id: W0PHM1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

1247726:MIM RS03735
gene id: 1247726:MIM_RS03735
uniprot id: W0P7Y0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

1247726:MIM RS16920
gene id: 1247726:MIM_RS16920
uniprot id: W0PF51
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1247726:MIM RS21145
gene id: 1247726:MIM_RS21145
uniprot id: W0PJ53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

1247726:MIM RS05275
gene id: 1247726:MIM_RS05275
uniprot id: W0PCG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1247726:MIM RS04685
gene id: 1247726:MIM_RS04685
uniprot id: W0P8D5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1247726:MIM RS09125
gene id: 1247726:MIM_RS09125
uniprot id: W0PFH7
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS07295
gene id: 1247726:MIM_RS07295
uniprot id: W0PDH6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS13685
gene id: 1247726:MIM_RS13685
uniprot id: W0PD49
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1247726:MIM RS20900
gene id: 1247726:MIM_RS20900
uniprot id: W0PKC3
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1247726:MIM RS10410
gene id: 1247726:MIM_RS10410
uniprot id: W0PBE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS00720
gene id: 1247726:MIM_RS00720
uniprot id: W0PB28
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

1247726:MIM RS21070
gene id: 1247726:MIM_RS21070
uniprot id: W0PM03
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS21885
gene id: 1247726:MIM_RS21885
uniprot id: W0PKX6
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

1247726:MIM RS03020
gene id: 1247726:MIM_RS03020
uniprot id: W0PCF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

1247726:MIM RS16925
gene id: 1247726:MIM_RS16925
uniprot id: W0PHN1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1247726:MIM RS13625
gene id: 1247726:MIM_RS13625
uniprot id: W0PCP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PstS family.
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

1247726:MIM RS08410
gene id: 1247726:MIM_RS08410
uniprot id: W0PF36
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

1247726:MIM RS20420
gene id: 1247726:MIM_RS20420
uniprot id: W0PK37
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS11815
gene id: 1247726:MIM_RS11815
uniprot id: W0PFQ5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1247726:MIM RS04275
gene id: 1247726:MIM_RS04275
uniprot id: W0PBR5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS04080
gene id: 1247726:MIM_RS04080
uniprot id: W0PBT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS01375
gene id: 1247726:MIM_RS01375
uniprot id: W0PBD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS11140
gene id: 1247726:MIM_RS11140
uniprot id: W0PFE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

1247726:MIM RS16770
gene id: 1247726:MIM_RS16770
uniprot id: W0PF34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS02950
gene id: 1247726:MIM_RS02950
uniprot id: W0P728
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

1247726:MIM RS12950
gene id: 1247726:MIM_RS12950
uniprot id: W0PCQ7
names: Similarity
messages: Belongs to the universal stress protein A family.

1247726:MIM RS20210
gene id: 1247726:MIM_RS20210
uniprot id: W0PLL2
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1247726:MIM RS15985
gene id: 1247726:MIM_RS15985
uniprot id: W0PI25
names: Similarity
messages: Belongs to the GcvT family.

1247726:MIM RS00420
gene id: 1247726:MIM_RS00420
uniprot id: W0P620
names: Similarity
messages: Belongs to the type III secretion exporter family.

1247726:MIM RS19830
gene id: 1247726:MIM_RS19830
uniprot id: W0PH40
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS04435
gene id: 1247726:MIM_RS04435
uniprot id: W0P7W9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1247726:MIM RS08930
gene id: 1247726:MIM_RS08930
uniprot id: W0PFE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS02460
gene id: 1247726:MIM_RS02460
uniprot id: W0PBZ4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS07020
gene id: 1247726:MIM_RS07020
uniprot id: W0P9L0
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.
messages: The heme is bound between the two transmembrane subunits.

1247726:MIM RS00975
gene id: 1247726:MIM_RS00975
uniprot id: W0P9X5
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS05415
gene id: 1247726:MIM_RS05415
uniprot id: W0P8T8
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

1247726:MIM RS13115
gene id: 1247726:MIM_RS13115
uniprot id: W0PGT9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1247726:MIM RS20500
gene id: 1247726:MIM_RS20500
uniprot id: W0PFY8
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1247726:MIM RS16195
gene id: 1247726:MIM_RS16195
uniprot id: W0PEC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1247726:MIM RS08275
gene id: 1247726:MIM_RS08275
uniprot id: W0PF02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

1247726:MIM RS02830
gene id: 1247726:MIM_RS02830
uniprot id: W0P7C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1247726:MIM RS03580
gene id: 1247726:MIM_RS03580
uniprot id: W0PBK3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1247726:MIM RS17455
gene id: 1247726:MIM_RS17455
uniprot id: W0PK64
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

1247726:MIM RS07760
gene id: 1247726:MIM_RS07760
uniprot id: W0PDR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1247726:MIM RS11250
gene id: 1247726:MIM_RS11250
uniprot id: W0PBJ5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1247726:MIM RS09575
gene id: 1247726:MIM_RS09575
uniprot id: W0PFQ7
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

1247726:MIM RS02955
gene id: 1247726:MIM_RS02955
uniprot id: W0PB60
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

1247726:MIM RS14240
gene id: 1247726:MIM_RS14240
uniprot id: W0PIJ8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS20205
gene id: 1247726:MIM_RS20205
uniprot id: W0PIT1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1247726:MIM RS04290
gene id: 1247726:MIM_RS04290
uniprot id: W0PBY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS15495
gene id: 1247726:MIM_RS15495
uniprot id: W0PHT1
names: Function
names: Similarity
messages: Belongs to the MurCDEF family. Mpl subfamily.
messages: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.

1247726:MIM RS21580
gene id: 1247726:MIM_RS21580
uniprot id: W0PHY9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS06970
gene id: 1247726:MIM_RS06970
uniprot id: W0P9K2
names: Similarity
messages: Belongs to the bleomycin resistance protein family.

1247726:MIM RS10030
gene id: 1247726:MIM_RS10030
uniprot id: W0PB78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS01820
gene id: 1247726:MIM_RS01820
uniprot id: W0PAD1
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1247726:MIM RS17165
gene id: 1247726:MIM_RS17165
uniprot id: W0PHR8
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS11485
gene id: 1247726:MIM_RS11485
uniprot id: W0PH58
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1247726:MIM RS20955
gene id: 1247726:MIM_RS20955
uniprot id: W0PKD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1247726:MIM RS14875
gene id: 1247726:MIM_RS14875
uniprot id: W0PDR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS11575
gene id: 1247726:MIM_RS11575
uniprot id: W0PGI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1247726:MIM RS12615
gene id: 1247726:MIM_RS12615
uniprot id: W0PG38
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1247726:MIM RS12645
gene id: 1247726:MIM_RS12645
uniprot id: W0PG39
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1247726:MIM RS07965
gene id: 1247726:MIM_RS07965
uniprot id: W0P9R3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

1247726:MIM RS02100
gene id: 1247726:MIM_RS02100
uniprot id: W0PBS6
names: Similarity
messages: Belongs to the pirin family.

1247726:MIM RS10305
gene id: 1247726:MIM_RS10305
uniprot id: W0PFG7
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1247726:MIM RS10470
gene id: 1247726:MIM_RS10470
uniprot id: W0PG61
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS10750
gene id: 1247726:MIM_RS10750
uniprot id: W0PBK4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS08435
gene id: 1247726:MIM_RS08435
uniprot id: W0PF70
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1247726:MIM RS18090
gene id: 1247726:MIM_RS18090
uniprot id: W0PFN3
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

1247726:MIM RS19605
gene id: 1247726:MIM_RS19605
uniprot id: W0PIK0
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1247726:MIM RS11085
gene id: 1247726:MIM_RS11085
uniprot id: W0PBW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS05305
gene id: 1247726:MIM_RS05305
uniprot id: W0P8R2
names: Function
names: Similarity
messages: Belongs to the Dus family. DusB subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1247726:MIM RS16070
gene id: 1247726:MIM_RS16070
uniprot id: W0PEA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS06080
gene id: 1247726:MIM_RS06080
uniprot id: W0PE07
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1247726:MIM RS13000
gene id: 1247726:MIM_RS13000
uniprot id: W0PHY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1247726:MIM RS11735
gene id: 1247726:MIM_RS11735
uniprot id: W0PFP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS07470
gene id: 1247726:MIM_RS07470
uniprot id: W0PDL3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1247726:MIM RS20435
gene id: 1247726:MIM_RS20435
uniprot id: W0PLP7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1247726:MIM RS07350
gene id: 1247726:MIM_RS07350
uniprot id: W0P9R9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1247726:MIM RS19135
gene id: 1247726:MIM_RS19135
uniprot id: W0PL00
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1247726:MIM RS12015
gene id: 1247726:MIM_RS12015
uniprot id: W0PGL0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS23465
gene id: 1247726:MIM_RS23465
uniprot id: W0P7D4
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

1247726:MIM RS02445
gene id: 1247726:MIM_RS02445
uniprot id: W0PAX5
names: Function
names: Similarity
messages: Belongs to the esterase D family.
messages: Serine hydrolase involved in the detoxification of formaldehyde.

1247726:MIM RS04835
gene id: 1247726:MIM_RS04835
uniprot id: W0PC88
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1247726:MIM RS17620
gene id: 1247726:MIM_RS17620
uniprot id: W0PK85
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1247726:MIM RS06380
gene id: 1247726:MIM_RS06380
uniprot id: W0P9B4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

1247726:MIM RS08535
gene id: 1247726:MIM_RS08535
uniprot id: W0PEM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1247726:MIM RS15655
gene id: 1247726:MIM_RS15655
uniprot id: W0PHW0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.
messages: Membrane

1247726:MIM RS13930
gene id: 1247726:MIM_RS13930
uniprot id: W0PIH0
names: Similarity
messages: Belongs to the UPF0310 family.

1247726:MIM RS14215
gene id: 1247726:MIM_RS14215
uniprot id: W0PIJ5
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

1247726:MIM RS14045
gene id: 1247726:MIM_RS14045
uniprot id: W0PH52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

1247726:MIM RS01155
gene id: 1247726:MIM_RS01155
uniprot id: W0PB98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1247726:MIM RS16590
gene id: 1247726:MIM_RS16590
uniprot id: W0PIH1
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

1247726:MIM RS16235
gene id: 1247726:MIM_RS16235
uniprot id: W0PJH0
names: Similarity
names: Subunit
messages: Belongs to the muconolactone Delta-isomerase family.
messages: Homodecamer.

1247726:MIM RS13080
gene id: 1247726:MIM_RS13080
uniprot id: W0PHZ5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS10665
gene id: 1247726:MIM_RS10665
uniprot id: W0PFP1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1247726:MIM RS01005
gene id: 1247726:MIM_RS01005
uniprot id: W0PB75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1247726:MIM RS09710
gene id: 1247726:MIM_RS09710
uniprot id: W0PF59
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1247726:MIM RS12270
gene id: 1247726:MIM_RS12270
uniprot id: W0PGM7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1247726:MIM RS04840
gene id: 1247726:MIM_RS04840
uniprot id: W0P8G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS00075
gene id: 1247726:MIM_RS00075
uniprot id: W0P5I0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1247726:MIM RS21490
gene id: 1247726:MIM_RS21490
uniprot id: W0PGC0
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1247726:MIM RS21735
gene id: 1247726:MIM_RS21735
uniprot id: W0PKS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS06260
gene id: 1247726:MIM_RS06260
uniprot id: W0PE34
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

1247726:MIM RS19330
gene id: 1247726:MIM_RS19330
uniprot id: W0PFD9
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS19600
gene id: 1247726:MIM_RS19600
uniprot id: W0PH05
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.

1247726:MIM RS14285
gene id: 1247726:MIM_RS14285
uniprot id: W0PGJ2
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS20560
gene id: 1247726:MIM_RS20560
uniprot id: W0PHE5
names: Similarity
messages: Belongs to the CutA family.

1247726:MIM RS21750
gene id: 1247726:MIM_RS21750
uniprot id: W0PMC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1247726:MIM RS06455
gene id: 1247726:MIM_RS06455
uniprot id: W0P9C9
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1247726:MIM RS02355
gene id: 1247726:MIM_RS02355
uniprot id: W0PAM8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

1247726:MIM RS08630
gene id: 1247726:MIM_RS08630
uniprot id: W0PE38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS13810
gene id: 1247726:MIM_RS13810
uniprot id: W0PCV7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1247726:MIM RS20665
gene id: 1247726:MIM_RS20665
uniprot id: W0PHG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS08375
gene id: 1247726:MIM_RS08375
uniprot id: W0PAB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

1247726:MIM RS14685
gene id: 1247726:MIM_RS14685
uniprot id: W0PIR4
names: Similarity
messages: Belongs to the PhoH family.

1247726:MIM RS12280
gene id: 1247726:MIM_RS12280
uniprot id: W0PFZ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

1247726:MIM RS02610
gene id: 1247726:MIM_RS02610
uniprot id: W0PC24
names: Similarity
messages: Belongs to the GST superfamily. HSP26 family.

1247726:MIM RS12710
gene id: 1247726:MIM_RS12710
uniprot id: W0PGQ9
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS06585
gene id: 1247726:MIM_RS06585
uniprot id: W0P913
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1247726:MIM RS03120
gene id: 1247726:MIM_RS03120
uniprot id: W0PB58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS06735
gene id: 1247726:MIM_RS06735
uniprot id: W0P9G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS18420
gene id: 1247726:MIM_RS18420
uniprot id: W0PKM6
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1247726:MIM RS03525
gene id: 1247726:MIM_RS03525
uniprot id: W0PBI6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1247726:MIM RS09720
gene id: 1247726:MIM_RS09720
uniprot id: W0PEJ3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1247726:MIM RS08810
gene id: 1247726:MIM_RS08810
uniprot id: W0PAL5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

1247726:MIM RS16860
gene id: 1247726:MIM_RS16860
uniprot id: W0PF43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1247726:MIM RS20820
gene id: 1247726:MIM_RS20820
uniprot id: W0PG30
names: Similarity
messages: Belongs to the hyi family.

1247726:MIM RS13970
gene id: 1247726:MIM_RS13970
uniprot id: W0PH43
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1247726:MIM RS11295
gene id: 1247726:MIM_RS11295
uniprot id: W0PH36
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1247726:MIM RS05430
gene id: 1247726:MIM_RS05430
uniprot id: W0PDM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS21695
gene id: 1247726:MIM_RS21695
uniprot id: W0PJE4
names: Similarity
messages: Belongs to the HMG-CoA lyase family.
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1247726:MIM RS01685
gene id: 1247726:MIM_RS01685
uniprot id: W0P6P4
names: Similarity
messages: Belongs to the Smg family.

1247726:MIM RS07015
gene id: 1247726:MIM_RS07015
uniprot id: W0PDC2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.
messages: The heme is bound between the two transmembrane subunits.

1247726:MIM RS14395
gene id: 1247726:MIM_RS14395
uniprot id: W0PD65
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1247726:MIM RS03360
gene id: 1247726:MIM_RS03360
uniprot id: W0PCK8
names: Function
names: Similarity
messages: Belongs to the ClpA/ClpB family.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.

1247726:MIM RS12585
gene id: 1247726:MIM_RS12585
uniprot id: W0PCJ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YceF subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1247726:MIM RS12870
gene id: 1247726:MIM_RS12870
uniprot id: W0PCP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

1247726:MIM RS02020
gene id: 1247726:MIM_RS02020
uniprot id: W0PBR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

1247726:MIM RS01555
gene id: 1247726:MIM_RS01555
uniprot id: W0PA82
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1247726:MIM RS20680
gene id: 1247726:MIM_RS20680
uniprot id: W0PG11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

1247726:MIM RS13845
gene id: 1247726:MIM_RS13845
uniprot id: W0PD92
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

1247726:MIM RS12115
gene id: 1247726:MIM_RS12115
uniprot id: W0PBX8
names: Similarity
messages: Belongs to the barstar family.

1247726:MIM RS20655
gene id: 1247726:MIM_RS20655
uniprot id: W0PG08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1247726:MIM RS14070
gene id: 1247726:MIM_RS14070
uniprot id: W0PH53
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

1247726:MIM RS04555
gene id: 1247726:MIM_RS04555
uniprot id: W0PBW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

1247726:MIM RS05080
gene id: 1247726:MIM_RS05080
uniprot id: W0PDG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsQ/DivIB family. FtsQ subfamily.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

1247726:MIM RS14590
gene id: 1247726:MIM_RS14590
uniprot id: W0PHC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1247726:MIM RS10495
gene id: 1247726:MIM_RS10495
uniprot id: W0PG65
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS16720
gene id: 1247726:MIM_RS16720
uniprot id: W0PHJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS12175
gene id: 1247726:MIM_RS12175
uniprot id: W0PCD3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS11285
gene id: 1247726:MIM_RS11285
uniprot id: W0PC01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1247726:MIM RS15525
gene id: 1247726:MIM_RS15525
uniprot id: W0PE15
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

1247726:MIM RS00680
gene id: 1247726:MIM_RS00680
uniprot id: W0PA08
names: Subunit
messages: Homodimer.

1247726:MIM RS08845
gene id: 1247726:MIM_RS08845
uniprot id: W0PE63
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS06320
gene id: 1247726:MIM_RS06320
uniprot id: W0P8X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1247726:MIM RS21540
gene id: 1247726:MIM_RS21540
uniprot id: W0PKP2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

1247726:MIM RS00960
gene id: 1247726:MIM_RS00960
uniprot id: W0P602
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1247726:MIM RS12110
gene id: 1247726:MIM_RS12110
uniprot id: W0PHF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell membrane
messages: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
messages: Membrane

1247726:MIM RS20460
gene id: 1247726:MIM_RS20460
uniprot id: W0PHC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1247726:MIM RS07845
gene id: 1247726:MIM_RS07845
uniprot id: W0PA12
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1247726:MIM RS08860
gene id: 1247726:MIM_RS08860
uniprot id: W0PES3
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

1247726:MIM RS17120
gene id: 1247726:MIM_RS17120
uniprot id: W0PK01
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1247726:MIM RS04795
gene id: 1247726:MIM_RS04795
uniprot id: W0PC05
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1247726:MIM RS07465
gene id: 1247726:MIM_RS07465
uniprot id: W0P9G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1247726:MIM RS00015
gene id: 1247726:MIM_RS00015
uniprot id: W0P5Q2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1247726:MIM RS10510
gene id: 1247726:MIM_RS10510
uniprot id: W0PBG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1247726:MIM RS03470
gene id: 1247726:MIM_RS03470
uniprot id: W0P7F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS07545
gene id: 1247726:MIM_RS07545
uniprot id: W0PEM5
names: Function
names: Similarity
messages: Belongs to the PqqC family.
messages: Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.

1247726:MIM RS13965
gene id: 1247726:MIM_RS13965
uniprot id: W0PCZ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1247726:MIM RS09580
gene id: 1247726:MIM_RS09580
uniprot id: W0PAM6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1247726:MIM RS16470
gene id: 1247726:MIM_RS16470
uniprot id: W0PIF8
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

1247726:MIM RS18970
gene id: 1247726:MIM_RS18970
uniprot id: W0PJ93
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

1247726:MIM RS15175
gene id: 1247726:MIM_RS15175
uniprot id: W0PIW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS08485
gene id: 1247726:MIM_RS08485
uniprot id: W0PE24
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS08765
gene id: 1247726:MIM_RS08765
uniprot id: W0PE51
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

1247726:MIM RS04255
gene id: 1247726:MIM_RS04255
uniprot id: W0P7T7
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.

1247726:MIM RS02240
gene id: 1247726:MIM_RS02240
uniprot id: W0P6M9
names: Similarity
messages: Belongs to the PrpD family.

1247726:MIM RS21175
gene id: 1247726:MIM_RS21175
uniprot id: W0PM23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1247726:MIM RS22095
gene id: 1247726:MIM_RS22095
uniprot id: W0PFS4
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

1247726:MIM RS15865
gene id: 1247726:MIM_RS15865
uniprot id: W0PGX0
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS08640
gene id: 1247726:MIM_RS08640
uniprot id: W0PA65
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS01895
gene id: 1247726:MIM_RS01895
uniprot id: W0P6S8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS11105
gene id: 1247726:MIM_RS11105
uniprot id: W0PGE4
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS13275
gene id: 1247726:MIM_RS13275
uniprot id: W0PCI3
names: Similarity
messages: Belongs to the SCO1/2 family.

1247726:MIM RS07300
gene id: 1247726:MIM_RS07300
uniprot id: W0P9R1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS11205
gene id: 1247726:MIM_RS11205
uniprot id: W0PGF5
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS02870
gene id: 1247726:MIM_RS02870
uniprot id: W0PC76
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

1247726:MIM RS05115
gene id: 1247726:MIM_RS05115
uniprot id: W0PCD8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1247726:MIM RS20905
gene id: 1247726:MIM_RS20905
uniprot id: W0PHM4
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1247726:MIM RS06100
gene id: 1247726:MIM_RS06100
uniprot id: W0PCQ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS07290
gene id: 1247726:MIM_RS07290
uniprot id: W0P9D9
names: Similarity
messages: Belongs to the PrpD family.

1247726:MIM RS08735
gene id: 1247726:MIM_RS08735
uniprot id: W0PAK3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1247726:MIM RS12515
gene id: 1247726:MIM_RS12515
uniprot id: W0PG27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1247726:MIM RS06910
gene id: 1247726:MIM_RS06910
uniprot id: W0PDA4
names: Similarity
messages: Belongs to the HIBADH-related family.

1247726:MIM RS14455
gene id: 1247726:MIM_RS14455
uniprot id: W0PDK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS19540
gene id: 1247726:MIM_RS19540
uniprot id: W0PJM4
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1247726:MIM RS07035
gene id: 1247726:MIM_RS07035
uniprot id: W0P991
names: Similarity
messages: Belongs to the SdhE FAD assembly factor family.

1247726:MIM RS15770
gene id: 1247726:MIM_RS15770
uniprot id: W0PJ71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Cell outer membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1247726:MIM RS04950
gene id: 1247726:MIM_RS04950
uniprot id: W0PC38
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family. HpsN subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD-dependent oxidation of (R)-2,3-dihydroxypropane-1-sulfonate to (R)-3-sulfolactate.

1247726:MIM RS20960
gene id: 1247726:MIM_RS20960
uniprot id: W0PHN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1247726:MIM RS09645
gene id: 1247726:MIM_RS09645
uniprot id: W0PEI3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1247726:MIM RS16915
gene id: 1247726:MIM_RS16915
uniprot id: W0PIK3
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

1247726:MIM RS21420
gene id: 1247726:MIM_RS21420
uniprot id: W0PKL9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS02890
gene id: 1247726:MIM_RS02890
uniprot id: W0PAY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptA family.
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane.
messages: Periplasm

1247726:MIM RS05390
gene id: 1247726:MIM_RS05390
uniprot id: W0P8T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-transferase family. Bpt subfamily.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.

1247726:MIM RS21475
gene id: 1247726:MIM_RS21475
uniprot id: W0PHX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1247726:MIM RS12715
gene id: 1247726:MIM_RS12715
uniprot id: W0PCM1
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS12005
gene id: 1247726:MIM_RS12005
uniprot id: W0PHD0
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1247726:MIM RS06590
gene id: 1247726:MIM_RS06590
uniprot id: W0PD51
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS21665
gene id: 1247726:MIM_RS21665
uniprot id: W0PI04
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1247726:MIM RS16535
gene id: 1247726:MIM_RS16535
uniprot id: W0PJQ9
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1247726:MIM RS11700
gene id: 1247726:MIM_RS11700
uniprot id: W0PGJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.

1247726:MIM RS16045
gene id: 1247726:MIM_RS16045
uniprot id: W0PE94
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS17995
gene id: 1247726:MIM_RS17995
uniprot id: W0PER7
names: Similarity
messages: Belongs to the CmpA/NrtA family.

1247726:MIM RS05940
gene id: 1247726:MIM_RS05940
uniprot id: W0P939
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS06430
gene id: 1247726:MIM_RS06430
uniprot id: W0P9C4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

1247726:MIM RS09595
gene id: 1247726:MIM_RS09595
uniprot id: W0PEH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1247726:MIM RS20715
gene id: 1247726:MIM_RS20715
uniprot id: W0PHH3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS22820
gene id: 1247726:MIM_RS22820
uniprot id: W0P9C0
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

1247726:MIM RS09275
gene id: 1247726:MIM_RS09275
uniprot id: W0PED1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS19790
gene id: 1247726:MIM_RS19790
uniprot id: W0PLE6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS06130
gene id: 1247726:MIM_RS06130
uniprot id: W0PE14
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1247726:MIM RS14940
gene id: 1247726:MIM_RS14940
uniprot id: W0PDG5
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1247726:MIM RS14420
gene id: 1247726:MIM_RS14420
uniprot id: W0PD68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS11510
gene id: 1247726:MIM_RS11510
uniprot id: W0PFI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS07860
gene id: 1247726:MIM_RS07860
uniprot id: W0P9P3
names: Similarity
messages: Belongs to the PhoH family.

1247726:MIM RS03440
gene id: 1247726:MIM_RS03440
uniprot id: W0PCM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

1247726:MIM RS18980
gene id: 1247726:MIM_RS18980
uniprot id: W0PID5
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family.

1247726:MIM RS08835
gene id: 1247726:MIM_RS08835
uniprot id: W0PAL8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS14535
gene id: 1247726:MIM_RS14535
uniprot id: W0PHB2
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1247726:MIM RS09725
gene id: 1247726:MIM_RS09725
uniprot id: W0PFU1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

1247726:MIM RS09610
gene id: 1247726:MIM_RS09610
uniprot id: W0PF48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LysR transcriptional regulatory family.
messages: Cytoplasm

1247726:MIM RS01100
gene id: 1247726:MIM_RS01100
uniprot id: W0P9Z7
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS16945
gene id: 1247726:MIM_RS16945
uniprot id: W0PF54
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1247726:MIM RS04740
gene id: 1247726:MIM_RS04740
uniprot id: W0PBZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS05055
gene id: 1247726:MIM_RS05055
uniprot id: W0PDF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1247726:MIM RS17100
gene id: 1247726:MIM_RS17100
uniprot id: W0PEG4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolB family.
messages: Cell outer membrane
messages: Membrane
messages: Monomer.

1247726:MIM RS08195
gene id: 1247726:MIM_RS08195
uniprot id: W0P9V4
names: Similarity
messages: Belongs to the UPF0053 family.

1247726:MIM RS03070
gene id: 1247726:MIM_RS03070
uniprot id: W0PB47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS04250
gene id: 1247726:MIM_RS04250
uniprot id: W0PD09
names: Similarity
messages: Belongs to the RuBisCO large chain family.

1247726:MIM RS13260
gene id: 1247726:MIM_RS13260
uniprot id: W0PCW1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS17875
gene id: 1247726:MIM_RS17875
uniprot id: W0PI29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS04935
gene id: 1247726:MIM_RS04935
uniprot id: W0P860
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS17325
gene id: 1247726:MIM_RS17325
uniprot id: W0PK39
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1247726:MIM RS05265
gene id: 1247726:MIM_RS05265
uniprot id: W0PDJ6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

1247726:MIM RS02780
gene id: 1247726:MIM_RS02780
uniprot id: W0P7B5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS12805
gene id: 1247726:MIM_RS12805
uniprot id: W0PHU2
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

1247726:MIM RS09990
gene id: 1247726:MIM_RS09990
uniprot id: W0PFX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS14625
gene id: 1247726:MIM_RS14625
uniprot id: W0PGM4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiD family.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
messages: Cell membrane
messages: Homohexamer.

1247726:MIM RS02050
gene id: 1247726:MIM_RS02050
uniprot id: W0P6J9
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaved by autocatalysis into a large and a small subunit.
messages: This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.

1247726:MIM RS15025
gene id: 1247726:MIM_RS15025
uniprot id: W0PDU0
names: Function
names: Subunit
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.

1247726:MIM RS14675
gene id: 1247726:MIM_RS14675
uniprot id: W0PDN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1247726:MIM RS02560
gene id: 1247726:MIM_RS02560
uniprot id: W0PC13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1247726:MIM RS04325
gene id: 1247726:MIM_RS04325
uniprot id: W0PBS4
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1247726:MIM RS01850
gene id: 1247726:MIM_RS01850
uniprot id: W0PBN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Homodimer.

1247726:MIM RS16940
gene id: 1247726:MIM_RS16940
uniprot id: W0PIK4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS13250
gene id: 1247726:MIM_RS13250
uniprot id: W0PCH9
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS20310
gene id: 1247726:MIM_RS20310
uniprot id: W0PLN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS20650
gene id: 1247726:MIM_RS20650
uniprot id: W0PLS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1247726:MIM RS15190
gene id: 1247726:MIM_RS15190
uniprot id: W0PDW0
names: Similarity
messages: Belongs to the asparaginase 1 family.

1247726:MIM RS11475
gene id: 1247726:MIM_RS11475
uniprot id: W0PC30
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1247726:MIM RS13350
gene id: 1247726:MIM_RS13350
uniprot id: W0PCJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS13890
gene id: 1247726:MIM_RS13890
uniprot id: W0PH31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS11480
gene id: 1247726:MIM_RS11480
uniprot id: W0PFI3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1247726:MIM RS03075
gene id: 1247726:MIM_RS03075
uniprot id: W0PCG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS00795
gene id: 1247726:MIM_RS00795
uniprot id: W0P9U7
names: Similarity
messages: Belongs to the SsuE family.

1247726:MIM RS17710
gene id: 1247726:MIM_RS17710
uniprot id: W0PIR6
names: Function
messages: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.

1247726:MIM RS12925
gene id: 1247726:MIM_RS12925
uniprot id: W0PG69
names: Function
names: Subcellular Location Annotation
messages: Periplasm
messages: Transfers electrons from cytochrome c551 to cytochrome oxidase.

1247726:MIM RS17475
gene id: 1247726:MIM_RS17475
uniprot id: W0PFB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS19580
gene id: 1247726:MIM_RS19580
uniprot id: W0PIJ7
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

1247726:MIM RS21715
gene id: 1247726:MIM_RS21715
uniprot id: W0PI21
names: Similarity
messages: Belongs to the PrpD family.

1247726:MIM RS09465
gene id: 1247726:MIM_RS09465
uniprot id: W0PAW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1247726:MIM RS04460
gene id: 1247726:MIM_RS04460
uniprot id: W0P7X4
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

1247726:MIM RS18815
gene id: 1247726:MIM_RS18815
uniprot id: W0PF35
names: Similarity
messages: Belongs to the UPF0225 family.

1247726:MIM RS00010
gene id: 1247726:MIM_RS00010
uniprot id: W0P9K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1247726:MIM RS15995
gene id: 1247726:MIM_RS15995
uniprot id: W0PE86
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS21710
gene id: 1247726:MIM_RS21710
uniprot id: W0PKS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS14525
gene id: 1247726:MIM_RS14525
uniprot id: W0PIP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

1247726:MIM RS07135
gene id: 1247726:MIM_RS07135
uniprot id: W0P9B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS01370
gene id: 1247726:MIM_RS01370
uniprot id: W0PA46
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1247726:MIM RS00910
gene id: 1247726:MIM_RS00910
uniprot id: W0P5Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS00115
gene id: 1247726:MIM_RS00115
uniprot id: W0P5R7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS14145
gene id: 1247726:MIM_RS14145
uniprot id: W0PD21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

1247726:MIM RS13525
gene id: 1247726:MIM_RS13525
uniprot id: W0PGC8
names: Similarity
messages: Belongs to the peptidase S8 family.

1247726:MIM RS19815
gene id: 1247726:MIM_RS19815
uniprot id: W0PLF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS15595
gene id: 1247726:MIM_RS15595
uniprot id: W0PDT2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1247726:MIM RS03805
gene id: 1247726:MIM_RS03805
uniprot id: W0PBP7
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.

1247726:MIM RS18535
gene id: 1247726:MIM_RS18535
uniprot id: W0PJ15
names: Similarity
messages: Belongs to the VgrG protein family.

1247726:MIM RS22160
gene id: 1247726:MIM_RS22160
uniprot id: W0PGP9
names: Function
names: Similarity
messages: Belongs to the DUF177 domain family.
messages: Plays a role in synthesis, processing and/or stability of 23S rRNA.

1247726:MIM RS10145
gene id: 1247726:MIM_RS10145
uniprot id: W0PAX4
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS00265
gene id: 1247726:MIM_RS00265
uniprot id: W0P5W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS09470
gene id: 1247726:MIM_RS09470
uniprot id: W0PEG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

1247726:MIM RS12535
gene id: 1247726:MIM_RS12535
uniprot id: W0PCJ0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1247726:MIM RS17370
gene id: 1247726:MIM_RS17370
uniprot id: W0PHU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

1247726:MIM RS07745
gene id: 1247726:MIM_RS07745
uniprot id: W0PDL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1247726:MIM RS10670
gene id: 1247726:MIM_RS10670
uniprot id: W0PBJ1
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

1247726:MIM RS00615
gene id: 1247726:MIM_RS00615
uniprot id: W0PB14
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS15685
gene id: 1247726:MIM_RS15685
uniprot id: W0PE48
names: Function
names: Subcellular Location Annotation
messages: Periplasm
messages: Transfers electrons from cytochrome c551 to cytochrome oxidase.

1247726:MIM RS18020
gene id: 1247726:MIM_RS18020
uniprot id: W0PKE4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS06095
gene id: 1247726:MIM_RS06095
uniprot id: W0P969
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1247726:MIM RS01270
gene id: 1247726:MIM_RS01270
uniprot id: W0PA27
names: Similarity
messages: Belongs to the bacterial PQQ dehydrogenase family.

1247726:MIM RS13710
gene id: 1247726:MIM_RS13710
uniprot id: W0PD70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1247726:MIM RS09310
gene id: 1247726:MIM_RS09310
uniprot id: W0PAH1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1247726:MIM RS09480
gene id: 1247726:MIM_RS09480
uniprot id: W0PAK5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

1247726:MIM RS17355
gene id: 1247726:MIM_RS17355
uniprot id: W0PEJ5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS09815
gene id: 1247726:MIM_RS09815
uniprot id: W0PF73
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS09770
gene id: 1247726:MIM_RS09770
uniprot id: W0PEK1
names: Function
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.

1247726:MIM RS07565
gene id: 1247726:MIM_RS07565
uniprot id: W0PDI4
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

1247726:MIM RS16540
gene id: 1247726:MIM_RS16540
uniprot id: W0PEA5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS12620
gene id: 1247726:MIM_RS12620
uniprot id: W0PHP7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase E/G family. RNase E subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per homotetramer.
messages: Cell inner membrane
messages: Cytoplasm
messages: Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.
messages: Homotetramer formed by a dimer of dimers.

1247726:MIM RS12440
gene id: 1247726:MIM_RS12440
uniprot id: W0PG16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

1247726:MIM RS12335
gene id: 1247726:MIM_RS12335
uniprot id: W0PHJ4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1247726:MIM RS10170
gene id: 1247726:MIM_RS10170
uniprot id: W0PAX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1247726:MIM RS18460
gene id: 1247726:MIM_RS18460
uniprot id: W0PFU9
names: Similarity
messages: Belongs to the ketopantoate reductase family.

1247726:MIM RS14855
gene id: 1247726:MIM_RS14855
uniprot id: W0PGP5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

1247726:MIM RS07455
gene id: 1247726:MIM_RS07455
uniprot id: W0PDG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1247726:MIM RS07525
gene id: 1247726:MIM_RS07525
uniprot id: W0PDM3
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS12865
gene id: 1247726:MIM_RS12865
uniprot id: W0PGS1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1247726:MIM RS00485
gene id: 1247726:MIM_RS00485
uniprot id: W0PAY6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS17775
gene id: 1247726:MIM_RS17775
uniprot id: W0PEN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS00495
gene id: 1247726:MIM_RS00495
uniprot id: W0P9X9
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS04590
gene id: 1247726:MIM_RS04590
uniprot id: W0PD64
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.

1247726:MIM RS20510
gene id: 1247726:MIM_RS20510
uniprot id: W0PHD5
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1247726:MIM RS16295
gene id: 1247726:MIM_RS16295
uniprot id: W0PI88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS02725
gene id: 1247726:MIM_RS02725
uniprot id: W0PB24
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

1247726:MIM RS20995
gene id: 1247726:MIM_RS20995
uniprot id: W0PLY6
names: Similarity
messages: Belongs to the FGGY kinase family.

1247726:MIM RS09210
gene id: 1247726:MIM_RS09210
uniprot id: W0PAF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS06290
gene id: 1247726:MIM_RS06290
uniprot id: W0PE42
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1247726:MIM RS08300
gene id: 1247726:MIM_RS08300
uniprot id: W0PF09
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

1247726:MIM RS03105
gene id: 1247726:MIM_RS03105
uniprot id: W0P789
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS09615
gene id: 1247726:MIM_RS09615
uniprot id: W0PB02
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

1247726:MIM RS11685
gene id: 1247726:MIM_RS11685
uniprot id: W0PFL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1247726:MIM RS19470
gene id: 1247726:MIM_RS19470
uniprot id: W0PGZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS04675
gene id: 1247726:MIM_RS04675
uniprot id: W0P809
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

1247726:MIM RS09970
gene id: 1247726:MIM_RS09970
uniprot id: W0PAU8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

1247726:MIM RS02715
gene id: 1247726:MIM_RS02715
uniprot id: W0PC45
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1247726:MIM RS10125
gene id: 1247726:MIM_RS10125
uniprot id: W0PFC2
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS15630
gene id: 1247726:MIM_RS15630
uniprot id: W0PE35
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

1247726:MIM RS11255
gene id: 1247726:MIM_RS11255
uniprot id: W0PGG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS15925
gene id: 1247726:MIM_RS15925
uniprot id: W0PDZ3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1247726:MIM RS02535
gene id: 1247726:MIM_RS02535
uniprot id: W0PC09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1247726:MIM RS06255
gene id: 1247726:MIM_RS06255
uniprot id: W0PCS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolA family.
messages: Monomer.
messages: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
messages: Periplasm

1247726:MIM RS22245
gene id: 1247726:MIM_RS22245
uniprot id: W0PFK2
names: Similarity
messages: Belongs to the VgrG protein family.

1247726:MIM RS11275
gene id: 1247726:MIM_RS11275
uniprot id: W0PBK0
names: Similarity
messages: Belongs to the peptidase S66 family.

1247726:MIM RS04165
gene id: 1247726:MIM_RS04165
uniprot id: W0PBP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS06040
gene id: 1247726:MIM_RS06040
uniprot id: W0P960
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

1247726:MIM RS21495
gene id: 1247726:MIM_RS21495
uniprot id: W0PKN6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS19170
gene id: 1247726:MIM_RS19170
uniprot id: W0PJH4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

1247726:MIM RS00580
gene id: 1247726:MIM_RS00580
uniprot id: W0P653
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS15405
gene id: 1247726:MIM_RS15405
uniprot id: W0PIZ3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1247726:MIM RS13645
gene id: 1247726:MIM_RS13645
uniprot id: W0PIA5
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1247726:MIM RS04680
gene id: 1247726:MIM_RS04680
uniprot id: W0PC56
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1247726:MIM RS01605
gene id: 1247726:MIM_RS01605
uniprot id: W0PA95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS01460
gene id: 1247726:MIM_RS01460
uniprot id: W0PAE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS01870
gene id: 1247726:MIM_RS01870
uniprot id: W0P6S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein.
messages: Oligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.

1247726:MIM RS07990
gene id: 1247726:MIM_RS07990
uniprot id: W0P9S1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1247726:MIM RS04600
gene id: 1247726:MIM_RS04600
uniprot id: W0PC41
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS07060
gene id: 1247726:MIM_RS07060
uniprot id: W0P996
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

1247726:MIM RS09980
gene id: 1247726:MIM_RS09980
uniprot id: W0PB68
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.

1247726:MIM RS06815
gene id: 1247726:MIM_RS06815
uniprot id: W0PD40
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS16985
gene id: 1247726:MIM_RS16985
uniprot id: W0PEF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1247726:MIM RS18140
gene id: 1247726:MIM_RS18140
uniprot id: W0PET6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS11430
gene id: 1247726:MIM_RS11430
uniprot id: W0PH51
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1247726:MIM RS14585
gene id: 1247726:MIM_RS14585
uniprot id: W0PD96
names: Similarity
messages: Belongs to the transketolase family.

1247726:MIM RS02640
gene id: 1247726:MIM_RS02640
uniprot id: W0PC29
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

1247726:MIM RS17170
gene id: 1247726:MIM_RS17170
uniprot id: W0PCL4
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

1247726:MIM RS08245
gene id: 1247726:MIM_RS08245
uniprot id: W0PCL4
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

1247726:MIM RS12285
gene id: 1247726:MIM_RS12285
uniprot id: W0PHI6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1247726:MIM RS00195
gene id: 1247726:MIM_RS00195
uniprot id: W0P9G7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1247726:MIM RS02325
gene id: 1247726:MIM_RS02325
uniprot id: W0P714
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1247726:MIM RS03880
gene id: 1247726:MIM_RS03880
uniprot id: W0PBR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1247726:MIM RS18075
gene id: 1247726:MIM_RS18075
uniprot id: W0PI52
names: Similarity
messages: Belongs to the peptidase S33 family.

1247726:MIM RS21015
gene id: 1247726:MIM_RS21015
uniprot id: W0PJ36
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1247726:MIM RS13865
gene id: 1247726:MIM_RS13865
uniprot id: W0PH27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS10660
gene id: 1247726:MIM_RS10660
uniprot id: W0PB65
names: Similarity
messages: Belongs to the PrpD family.

1247726:MIM RS13670
gene id: 1247726:MIM_RS13670
uniprot id: W0PIA8
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1247726:MIM RS07025
gene id: 1247726:MIM_RS07025
uniprot id: W0PD71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS10705
gene id: 1247726:MIM_RS10705
uniprot id: W0PG91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS01225
gene id: 1247726:MIM_RS01225
uniprot id: W0PA18
names: Similarity
messages: Belongs to the peptidase M20A family. ArgE subfamily.

1247726:MIM RS00375
gene id: 1247726:MIM_RS00375
uniprot id: W0PAU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YscJ lipoprotein family.
messages: Cell outer membrane
messages: Membrane

1247726:MIM RS06545
gene id: 1247726:MIM_RS06545
uniprot id: W0P9E1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1247726:MIM RS00215
gene id: 1247726:MIM_RS00215
uniprot id: W0P5T8
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

1247726:MIM RS05945
gene id: 1247726:MIM_RS05945
uniprot id: W0PCN3
names: Similarity
messages: Belongs to the PrpD family.

1247726:MIM RS12265
gene id: 1247726:MIM_RS12265
uniprot id: W0PC08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

1247726:MIM RS10140
gene id: 1247726:MIM_RS10140
uniprot id: W0PG09
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1247726:MIM RS12305
gene id: 1247726:MIM_RS12305
uniprot id: W0PFZ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer.

1247726:MIM RS11750
gene id: 1247726:MIM_RS11750
uniprot id: W0PBS5
names: Similarity
messages: Belongs to the UxaA family.

1247726:MIM RS09735
gene id: 1247726:MIM_RS09735
uniprot id: W0PF62
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1247726:MIM RS09765
gene id: 1247726:MIM_RS09765
uniprot id: W0PB27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HscB family.
messages: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.
messages: Interacts with HscA and stimulates its ATPase activity.

1247726:MIM RS20430
gene id: 1247726:MIM_RS20430
uniprot id: W0PIU6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS01670
gene id: 1247726:MIM_RS01670
uniprot id: W0PBJ7
names: Similarity
messages: Belongs to the type IA topoisomerase family.

1247726:MIM RS10195
gene id: 1247726:MIM_RS10195
uniprot id: W0PAY4
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS09700
gene id: 1247726:MIM_RS09700
uniprot id: W0PFT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

1247726:MIM RS12940
gene id: 1247726:MIM_RS12940
uniprot id: W0PCD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1247726:MIM RS01030
gene id: 1247726:MIM_RS01030
uniprot id: W0PB80
names: Cofactor
messages: Binds 3 heme c groups covalently per subunit.

1247726:MIM RS08685
gene id: 1247726:MIM_RS08685
uniprot id: W0PAJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

1247726:MIM RS19325
gene id: 1247726:MIM_RS19325
uniprot id: W0PL59
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

1247726:MIM RS11615
gene id: 1247726:MIM_RS11615
uniprot id: W0PH75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1247726:MIM RS15600
gene id: 1247726:MIM_RS15600
uniprot id: W0PHV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1247726:MIM RS11695
gene id: 1247726:MIM_RS11695
uniprot id: W0PBR7
names: Subcellular Location Annotation
messages: Cytoplasm

1247726:MIM RS16685
gene id: 1247726:MIM_RS16685
uniprot id: W0PII0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS12955
gene id: 1247726:MIM_RS12955
uniprot id: W0PG71
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS07125
gene id: 1247726:MIM_RS07125
uniprot id: W0PD91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS07885
gene id: 1247726:MIM_RS07885
uniprot id: W0P9P7
names: Similarity
messages: Belongs to the threonine synthase family.

1247726:MIM RS05010
gene id: 1247726:MIM_RS05010
uniprot id: W0P874
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.

1247726:MIM RS03865
gene id: 1247726:MIM_RS03865
uniprot id: W0PBI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1247726:MIM RS19215
gene id: 1247726:MIM_RS19215
uniprot id: W0PL41
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

1247726:MIM RS14185
gene id: 1247726:MIM_RS14185
uniprot id: W0PGI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreF family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1247726:MIM RS15845
gene id: 1247726:MIM_RS15845
uniprot id: W0PJ97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

1247726:MIM RS10230
gene id: 1247726:MIM_RS10230
uniprot id: W0PBB2
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1247726:MIM RS12215
gene id: 1247726:MIM_RS12215
uniprot id: W0PBZ7
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS11520
gene id: 1247726:MIM_RS11520
uniprot id: W0PBN6
names: Subcellular Location Annotation
messages: Cytoplasm

1247726:MIM RS08155
gene id: 1247726:MIM_RS08155
uniprot id: W0PA69
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

1247726:MIM RS20450
gene id: 1247726:MIM_RS20450
uniprot id: W0PK42
names: Function
names: Similarity
messages: Belongs to the frataxin family.
messages: Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.

1247726:MIM RS02670
gene id: 1247726:MIM_RS02670
uniprot id: W0P6W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS16145
gene id: 1247726:MIM_RS16145
uniprot id: W0PEB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS20765
gene id: 1247726:MIM_RS20765
uniprot id: W0PKA2
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS03080
gene id: 1247726:MIM_RS03080
uniprot id: W0P777
names: Similarity
messages: Belongs to the peptidase S58 family.

1247726:MIM RS02265
gene id: 1247726:MIM_RS02265
uniprot id: W0P6N5
names: Function
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

1247726:MIM RS17095
gene id: 1247726:MIM_RS17095
uniprot id: W0PJZ5
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

1247726:MIM RS07400
gene id: 1247726:MIM_RS07400
uniprot id: W0P9T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS05045
gene id: 1247726:MIM_RS05045
uniprot id: W0P8K5
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS08180
gene id: 1247726:MIM_RS08180
uniprot id: W0PA74
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

1247726:MIM RS07740
gene id: 1247726:MIM_RS07740
uniprot id: W0P9Z3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1247726:MIM RS20180
gene id: 1247726:MIM_RS20180
uniprot id: W0PIS9
names: Similarity
messages: Belongs to the TPP enzyme family.

1247726:MIM RS01715
gene id: 1247726:MIM_RS01715
uniprot id: W0P6P9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1247726:MIM RS01535
gene id: 1247726:MIM_RS01535
uniprot id: W0PBG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1247726:MIM RS08875
gene id: 1247726:MIM_RS08875
uniprot id: W0PFC4
names: Similarity
messages: Belongs to the CmpA/NrtA family.

1247726:MIM RS03810
gene id: 1247726:MIM_RS03810
uniprot id: W0P7Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1247726:MIM RS13030
gene id: 1247726:MIM_RS13030
uniprot id: W0PCE7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1247726:MIM RS10675
gene id: 1247726:MIM_RS10675
uniprot id: W0PEY9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS20965
gene id: 1247726:MIM_RS20965
uniprot id: W0PJ26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1247726:MIM RS17080
gene id: 1247726:MIM_RS17080
uniprot id: W0PF66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1247726:MIM RS00410
gene id: 1247726:MIM_RS00410
uniprot id: W0P5Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Membrane

1247726:MIM RS19865
gene id: 1247726:MIM_RS19865
uniprot id: W0PIP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS16400
gene id: 1247726:MIM_RS16400
uniprot id: W0PEH0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS06715
gene id: 1247726:MIM_RS06715
uniprot id: W0PD20
names: Similarity
messages: Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family.

1247726:MIM RS19290
gene id: 1247726:MIM_RS19290
uniprot id: W0PGX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS10175
gene id: 1247726:MIM_RS10175
uniprot id: W0PFD6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS07505
gene id: 1247726:MIM_RS07505
uniprot id: W0P9U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS18560
gene id: 1247726:MIM_RS18560
uniprot id: W0PJ20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1247726:MIM RS15575
gene id: 1247726:MIM_RS15575
uniprot id: W0PHU6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

1247726:MIM RS08475
gene id: 1247726:MIM_RS08475
uniprot id: W0PEL8
names: Similarity
messages: Belongs to the thioesterase PaaI family.

1247726:MIM RS10045
gene id: 1247726:MIM_RS10045
uniprot id: W0PAW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1247726:MIM RS21080
gene id: 1247726:MIM_RS21080
uniprot id: W0PKF2
names: Similarity
messages: Belongs to the leucine-binding protein family.

1247726:MIM RS08970
gene id: 1247726:MIM_RS08970
uniprot id: W0PAN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS18470
gene id: 1247726:MIM_RS18470
uniprot id: W0PKN8
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

1247726:MIM RS08405
gene id: 1247726:MIM_RS08405
uniprot id: W0PE01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS16640
gene id: 1247726:MIM_RS16640
uniprot id: W0PJS4
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS18810
gene id: 1247726:MIM_RS18810
uniprot id: W0PKU3
names: Similarity
messages: Belongs to the AHA1 family.

1247726:MIM RS06410
gene id: 1247726:MIM_RS06410
uniprot id: W0PCV5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1247726:MIM RS03680
gene id: 1247726:MIM_RS03680
uniprot id: W0PBM2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1247726:MIM RS06905
gene id: 1247726:MIM_RS06905
uniprot id: W0P965
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1247726:MIM RS16510
gene id: 1247726:MIM_RS16510
uniprot id: W0PJQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS17420
gene id: 1247726:MIM_RS17420
uniprot id: W0PFB1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

1247726:MIM RS17665
gene id: 1247726:MIM_RS17665
uniprot id: W0PFD2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1247726:MIM RS10335
gene id: 1247726:MIM_RS10335
uniprot id: W0PBD4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1247726:MIM RS06665
gene id: 1247726:MIM_RS06665
uniprot id: W0PD63
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

1247726:MIM RS06465
gene id: 1247726:MIM_RS06465
uniprot id: W0PE67
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.

1247726:MIM RS00850
gene id: 1247726:MIM_RS00850
uniprot id: W0PB52
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS03240
gene id: 1247726:MIM_RS03240
uniprot id: W0P7P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS03695
gene id: 1247726:MIM_RS03695
uniprot id: W0PCQ9
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

1247726:MIM RS10130
gene id: 1247726:MIM_RS10130
uniprot id: W0PB96
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS02635
gene id: 1247726:MIM_RS02635
uniprot id: W0PAT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

1247726:MIM RS15620
gene id: 1247726:MIM_RS15620
uniprot id: W0PDT6
names: Cofactor
names: Function
names: Subunit
messages: Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.
messages: Binds 1 FAD per subunit.
messages: Binds 1 FMN per subunit.
messages: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.

1247726:MIM RS15750
gene id: 1247726:MIM_RS15750
uniprot id: W0PDV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1247726:MIM RS16370
gene id: 1247726:MIM_RS16370
uniprot id: W0PIE5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS02815
gene id: 1247726:MIM_RS02815
uniprot id: W0PC65
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

1247726:MIM RS16120
gene id: 1247726:MIM_RS16120
uniprot id: W0PEA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1247726:MIM RS03815
gene id: 1247726:MIM_RS03815
uniprot id: W0PBH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

1247726:MIM RS04500
gene id: 1247726:MIM_RS04500
uniprot id: W0PBU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

1247726:MIM RS12460
gene id: 1247726:MIM_RS12460
uniprot id: W0PCH8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS03920
gene id: 1247726:MIM_RS03920
uniprot id: W0PCU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS08320
gene id: 1247726:MIM_RS08320
uniprot id: W0PDW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

1247726:MIM RS14670
gene id: 1247726:MIM_RS14670
uniprot id: W0PHD8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1247726:MIM RS18475
gene id: 1247726:MIM_RS18475
uniprot id: W0PEZ0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1247726:MIM RS19990
gene id: 1247726:MIM_RS19990
uniprot id: W0PIQ7
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

1247726:MIM RS08045
gene id: 1247726:MIM_RS08045
uniprot id: W0PDW7
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS06550
gene id: 1247726:MIM_RS06550
uniprot id: W0PCY0
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS06900
gene id: 1247726:MIM_RS06900
uniprot id: W0PEC9
names: Similarity
messages: Belongs to the aspartokinase family.

1247726:MIM RS06075
gene id: 1247726:MIM_RS06075
uniprot id: W0PCQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1247726:MIM RS21505
gene id: 1247726:MIM_RS21505
uniprot id: W0PHT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1247726:MIM RS04005
gene id: 1247726:MIM_RS04005
uniprot id: W0P820
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

1247726:MIM RS09265
gene id: 1247726:MIM_RS09265
uniprot id: W0PEY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS08345
gene id: 1247726:MIM_RS08345
uniprot id: W0PAB1
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

1247726:MIM RS14065
gene id: 1247726:MIM_RS14065
uniprot id: W0PD08
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

1247726:MIM RS12375
gene id: 1247726:MIM_RS12375
uniprot id: W0PGN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

1247726:MIM RS11345
gene id: 1247726:MIM_RS11345
uniprot id: W0PC14
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1247726:MIM RS11800
gene id: 1247726:MIM_RS11800
uniprot id: W0PBT2
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

1247726:MIM RS15400
gene id: 1247726:MIM_RS15400
uniprot id: W0PGT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1247726:MIM RS04850
gene id: 1247726:MIM_RS04850
uniprot id: W0PDB3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS18565
gene id: 1247726:MIM_RS18565
uniprot id: W0PFW5
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1247726:MIM RS02930
gene id: 1247726:MIM_RS02930
uniprot id: W0PB55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

1247726:MIM RS19630
gene id: 1247726:MIM_RS19630
uniprot id: W0PH10
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS03260
gene id: 1247726:MIM_RS03260
uniprot id: W0P7B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS19810
gene id: 1247726:MIM_RS19810
uniprot id: W0PIN5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1247726:MIM RS12395
gene id: 1247726:MIM_RS12395
uniprot id: W0PC31
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

1247726:MIM RS12055
gene id: 1247726:MIM_RS12055
uniprot id: W0PHE1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

1247726:MIM RS16115
gene id: 1247726:MIM_RS16115
uniprot id: W0PI58
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

1247726:MIM RS13820
gene id: 1247726:MIM_RS13820
uniprot id: W0PD89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1247726:MIM RS16950
gene id: 1247726:MIM_RS16950
uniprot id: W0PHN6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1247726:MIM RS15695
gene id: 1247726:MIM_RS15695
uniprot id: W0PJ55
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

1247726:MIM RS07420
gene id: 1247726:MIM_RS07420
uniprot id: W0PDK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

1247726:MIM RS15135
gene id: 1247726:MIM_RS15135
uniprot id: W0PHN2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS07240
gene id: 1247726:MIM_RS07240
uniprot id: W0P9D0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS02045
gene id: 1247726:MIM_RS02045
uniprot id: W0PBR6
names: Similarity
messages: Belongs to the HSP15 family.

1247726:MIM RS13720
gene id: 1247726:MIM_RS13720
uniprot id: W0PIF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1247726:MIM RS03445
gene id: 1247726:MIM_RS03445
uniprot id: W0P7E8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1247726:MIM RS00315
gene id: 1247726:MIM_RS00315
uniprot id: W0P5X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS02485
gene id: 1247726:MIM_RS02485
uniprot id: W0PBZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS14375
gene id: 1247726:MIM_RS14375
uniprot id: W0PH90
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1247726:MIM RS20610
gene id: 1247726:MIM_RS20610
uniprot id: W0PK70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1247726:MIM RS12560
gene id: 1247726:MIM_RS12560
uniprot id: W0PCJ4
names: Similarity
messages: Belongs to the fabD family.

1247726:MIM RS14850
gene id: 1247726:MIM_RS14850
uniprot id: W0PDR5
names: Similarity
messages: Belongs to the DapA family.

1247726:MIM RS12775
gene id: 1247726:MIM_RS12775
uniprot id: W0PG51
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS00490
gene id: 1247726:MIM_RS00490
uniprot id: W0P5S8
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS06345
gene id: 1247726:MIM_RS06345
uniprot id: W0P8X6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS19585
gene id: 1247726:MIM_RS19585
uniprot id: W0PLA6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.
messages: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
messages: Cytoplasm
messages: Homodimer.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

1247726:MIM RS05950
gene id: 1247726:MIM_RS05950
uniprot id: W0PDY4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1247726:MIM RS17430
gene id: 1247726:MIM_RS17430
uniprot id: W0PK59
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS20645
gene id: 1247726:MIM_RS20645
uniprot id: W0PIX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1247726:MIM RS05970
gene id: 1247726:MIM_RS05970
uniprot id: W0PCN7
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase class-III family.

1247726:MIM RS20400
gene id: 1247726:MIM_RS20400
uniprot id: W0PHB6
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

1247726:MIM RS08600
gene id: 1247726:MIM_RS08600
uniprot id: W0PE37
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS18875
gene id: 1247726:MIM_RS18875
uniprot id: W0PJ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS21225
gene id: 1247726:MIM_RS21225
uniprot id: W0PM37
names: Similarity
messages: Belongs to the PrpD family.

1247726:MIM RS10300
gene id: 1247726:MIM_RS10300
uniprot id: W0PAZ8
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

1247726:MIM RS16965
gene id: 1247726:MIM_RS16965
uniprot id: W0PIK5
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

1247726:MIM RS07730
gene id: 1247726:MIM_RS07730
uniprot id: W0P9L7
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS04155
gene id: 1247726:MIM_RS04155
uniprot id: W0PBV0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS20945
gene id: 1247726:MIM_RS20945
uniprot id: W0PG55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1247726:MIM RS03740
gene id: 1247726:MIM_RS03740
uniprot id: W0PBG1
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS20495
gene id: 1247726:MIM_RS20495
uniprot id: W0PLQ5
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

1247726:MIM RS16065
gene id: 1247726:MIM_RS16065
uniprot id: W0PI51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS05300
gene id: 1247726:MIM_RS05300
uniprot id: W0PCG8
names: Similarity
messages: Belongs to the transcriptional regulatory Fis family.

1247726:MIM RS11540
gene id: 1247726:MIM_RS11540
uniprot id: W0PH66
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

1247726:MIM RS09755
gene id: 1247726:MIM_RS09755
uniprot id: W0PAQ9
names: Function
names: Similarity
messages: A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
messages: Belongs to the NifU family.

1247726:MIM RS12455
gene id: 1247726:MIM_RS12455
uniprot id: W0PGN8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS21615
gene id: 1247726:MIM_RS21615
uniprot id: W0PMA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS20840
gene id: 1247726:MIM_RS20840
uniprot id: W0PLV9
names: Similarity
messages: Belongs to the IlvD/Edd family.

1247726:MIM RS04560
gene id: 1247726:MIM_RS04560
uniprot id: W0PD60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

1247726:MIM RS09895
gene id: 1247726:MIM_RS09895
uniprot id: W0PF89
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family. GreB subfamily.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.

1247726:MIM RS17380
gene id: 1247726:MIM_RS17380
uniprot id: W0PEJ8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS11355
gene id: 1247726:MIM_RS11355
uniprot id: W0PH44
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1247726:MIM RS07380
gene id: 1247726:MIM_RS07380
uniprot id: W0PDE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS04525
gene id: 1247726:MIM_RS04525
uniprot id: W0PBV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS14190
gene id: 1247726:MIM_RS14190
uniprot id: W0PIJ4
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1247726:MIM RS03145
gene id: 1247726:MIM_RS03145
uniprot id: W0PB62
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

1247726:MIM RS03615
gene id: 1247726:MIM_RS03615
uniprot id: W0PBE3
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

1247726:MIM RS14220
gene id: 1247726:MIM_RS14220
uniprot id: W0PD35
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1247726:MIM RS10180
gene id: 1247726:MIM_RS10180
uniprot id: W0PB99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1247726:MIM RS07925
gene id: 1247726:MIM_RS07925
uniprot id: W0PA25
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1247726:MIM RS04720
gene id: 1247726:MIM_RS04720
uniprot id: W0PD90
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

1247726:MIM RS09605
gene id: 1247726:MIM_RS09605
uniprot id: W0PAN0
names: Similarity
messages: Belongs to the CFA/CMAS family.

1247726:MIM RS21650
gene id: 1247726:MIM_RS21650
uniprot id: W0PGD4
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1247726:MIM RS13070
gene id: 1247726:MIM_RS13070
uniprot id: W0PCS6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS07830
gene id: 1247726:MIM_RS07830
uniprot id: W0PES5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

1247726:MIM RS11505
gene id: 1247726:MIM_RS11505
uniprot id: W0PC35
names: Similarity
messages: Belongs to the P(II) protein family.

1247726:MIM RS01770
gene id: 1247726:MIM_RS01770
uniprot id: W0PAC3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS13375
gene id: 1247726:MIM_RS13375
uniprot id: W0PCJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS07575
gene id: 1247726:MIM_RS07575
uniprot id: W0P9I9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

1247726:MIM RS11635
gene id: 1247726:MIM_RS11635
uniprot id: W0PFK6
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1247726:MIM RS21910
gene id: 1247726:MIM_RS21910
uniprot id: W0P9M0
names: Similarity
messages: Belongs to the FliN/MopA/SpaO family.

1247726:MIM RS07700
gene id: 1247726:MIM_RS07700
uniprot id: W0PEQ3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1247726:MIM RS10355
gene id: 1247726:MIM_RS10355
uniprot id: W0PFH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS16185
gene id: 1247726:MIM_RS16185
uniprot id: W0PE33
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS12905
gene id: 1247726:MIM_RS12905
uniprot id: W0PHW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1247726:MIM RS18985
gene id: 1247726:MIM_RS18985
uniprot id: W0PKX3
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

1247726:MIM RS03100
gene id: 1247726:MIM_RS03100
uniprot id: W0PCG9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Maintains high levels of reduced glutathione.

1247726:MIM RS09685
gene id: 1247726:MIM_RS09685
uniprot id: W0PF57
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS04735
gene id: 1247726:MIM_RS04735
uniprot id: W0P8E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS10655
gene id: 1247726:MIM_RS10655
uniprot id: W0PG84
names: Similarity
messages: Belongs to the leucine-binding protein family.

1247726:MIM RS05920
gene id: 1247726:MIM_RS05920
uniprot id: W0PCM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS15145
gene id: 1247726:MIM_RS15145
uniprot id: W0PGR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS07390
gene id: 1247726:MIM_RS07390
uniprot id: W0P9F6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1247726:MIM RS06120
gene id: 1247726:MIM_RS06120
uniprot id: W0P974
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1247726:MIM RS02220
gene id: 1247726:MIM_RS02220
uniprot id: W0PAT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS00090
gene id: 1247726:MIM_RS00090
uniprot id: W0P5R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS04820
gene id: 1247726:MIM_RS04820
uniprot id: W0PC10
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1247726:MIM RS07040
gene id: 1247726:MIM_RS07040
uniprot id: W0PDC6
names: Similarity
messages: Belongs to the citrate synthase family.

1247726:MIM RS01190
gene id: 1247726:MIM_RS01190
uniprot id: W0PA94
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1247726:MIM RS06295
gene id: 1247726:MIM_RS06295
uniprot id: W0P8W6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1247726:MIM RS04115
gene id: 1247726:MIM_RS04115
uniprot id: W0PBN5
names: Function
names: Similarity
messages: Belongs to the CitG/MdcB family.
messages: Involved in the formation of 2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase.

1247726:MIM RS10040
gene id: 1247726:MIM_RS10040
uniprot id: W0PFY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1247726:MIM RS08625
gene id: 1247726:MIM_RS08625
uniprot id: W0PAI8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS09775
gene id: 1247726:MIM_RS09775
uniprot id: W0PFV3
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

1247726:MIM RS08315
gene id: 1247726:MIM_RS08315
uniprot id: W0PAA6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1247726:MIM RS09820
gene id: 1247726:MIM_RS09820
uniprot id: W0PB35
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1247726:MIM RS11465
gene id: 1247726:MIM_RS11465
uniprot id: W0PBM9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1247726:MIM RS09185
gene id: 1247726:MIM_RS09185
uniprot id: W0PAE7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS21170
gene id: 1247726:MIM_RS21170
uniprot id: W0PJ59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1247726:MIM RS21640
gene id: 1247726:MIM_RS21640
uniprot id: W0PJD6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

1247726:MIM RS19350
gene id: 1247726:MIM_RS19350
uniprot id: W0PL64
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

1247726:MIM RS03655
gene id: 1247726:MIM_RS03655
uniprot id: W0PBL8
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS07190
gene id: 1247726:MIM_RS07190
uniprot id: W0PDF8
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

1247726:MIM RS13840
gene id: 1247726:MIM_RS13840
uniprot id: W0PH23
names: Function
names: Similarity
messages: Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

1247726:MIM RS14655
gene id: 1247726:MIM_RS14655
uniprot id: W0PGN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1247726:MIM RS11865
gene id: 1247726:MIM_RS11865
uniprot id: W0PGK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS15480
gene id: 1247726:MIM_RS15480
uniprot id: W0PGT8
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1247726:MIM RS03790
gene id: 1247726:MIM_RS03790
uniprot id: W0PBH1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1247726:MIM RS08980
gene id: 1247726:MIM_RS08980
uniprot id: W0PFF0
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS08425
gene id: 1247726:MIM_RS08425
uniprot id: W0PAF5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS12570
gene id: 1247726:MIM_RS12570
uniprot id: W0PHM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

1247726:MIM RS11180
gene id: 1247726:MIM_RS11180
uniprot id: W0PGF2
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1247726:MIM RS12465
gene id: 1247726:MIM_RS12465
uniprot id: W0PG19
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

1247726:MIM RS03295
gene id: 1247726:MIM_RS03295
uniprot id: W0P7Q0
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

1247726:MIM RS03535
gene id: 1247726:MIM_RS03535
uniprot id: W0P7U4
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1247726:MIM RS19345
gene id: 1247726:MIM_RS19345
uniprot id: W0PIG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS04285
gene id: 1247726:MIM_RS04285
uniprot id: W0P7U1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1247726:MIM RS16085
gene id: 1247726:MIM_RS16085
uniprot id: W0PE16
names: Similarity
messages: Belongs to the TPP enzyme family.

1247726:MIM RS16255
gene id: 1247726:MIM_RS16255
uniprot id: W0PH28
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

1247726:MIM RS06915
gene id: 1247726:MIM_RS06915
uniprot id: W0P9J1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS05350
gene id: 1247726:MIM_RS05350
uniprot id: W0P8E2
names: Similarity
messages: Belongs to the DEAD box helicase family.

1247726:MIM RS19255
gene id: 1247726:MIM_RS19255
uniprot id: W0PFC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS11570
gene id: 1247726:MIM_RS11570
uniprot id: W0PBP4
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1247726:MIM RS07070
gene id: 1247726:MIM_RS07070
uniprot id: W0P9L9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

1247726:MIM RS14570
gene id: 1247726:MIM_RS14570
uniprot id: W0PDM1
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.

1247726:MIM RS04345
gene id: 1247726:MIM_RS04345
uniprot id: W0P876
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1247726:MIM RS20170
gene id: 1247726:MIM_RS20170
uniprot id: W0PJY9
names: Similarity
messages: Belongs to the oxoprolinase family.

1247726:MIM RS06995
gene id: 1247726:MIM_RS06995
uniprot id: W0P9K6
names: Similarity
messages: Belongs to the PrpD family.

1247726:MIM RS17485
gene id: 1247726:MIM_RS17485
uniprot id: W0PK68
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS08150
gene id: 1247726:MIM_RS08150
uniprot id: W0PDY2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1247726:MIM RS04760
gene id: 1247726:MIM_RS04760
uniprot id: W0P8F0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1247726:MIM RS02920
gene id: 1247726:MIM_RS02920
uniprot id: W0PC86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

1247726:MIM RS05150
gene id: 1247726:MIM_RS05150
uniprot id: W0PCE2
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS10260
gene id: 1247726:MIM_RS10260
uniprot id: W0PES2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1247726:MIM RS10280
gene id: 1247726:MIM_RS10280
uniprot id: W0PBC3
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

1247726:MIM RS17445
gene id: 1247726:MIM_RS17445
uniprot id: W0PFB5
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS01405
gene id: 1247726:MIM_RS01405
uniprot id: W0P683
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS07940
gene id: 1247726:MIM_RS07940
uniprot id: W0P9Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS10015
gene id: 1247726:MIM_RS10015
uniprot id: W0PFY1
names: Similarity
messages: Belongs to the leucine-binding protein family.

1247726:MIM RS15615
gene id: 1247726:MIM_RS15615
uniprot id: W0PJ40
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Binds 1 siroheme per subunit.
messages: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.

1247726:MIM RS13315
gene id: 1247726:MIM_RS13315
uniprot id: W0PGA9
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS09040
gene id: 1247726:MIM_RS09040
uniprot id: W0PEV1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS14540
gene id: 1247726:MIM_RS14540
uniprot id: W0PDL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Secreted

1247726:MIM RS02650
gene id: 1247726:MIM_RS02650
uniprot id: W0PB08
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

1247726:MIM RS14380
gene id: 1247726:MIM_RS14380
uniprot id: W0PDI8
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS17410
gene id: 1247726:MIM_RS17410
uniprot id: W0PEK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

1247726:MIM RS09570
gene id: 1247726:MIM_RS09570
uniprot id: W0PEH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

1247726:MIM RS00940
gene id: 1247726:MIM_RS00940
uniprot id: W0PA49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1247726:MIM RS12245
gene id: 1247726:MIM_RS12245
uniprot id: W0PGM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1247726:MIM RS04310
gene id: 1247726:MIM_RS04310
uniprot id: W0P7U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS09420
gene id: 1247726:MIM_RS09420
uniprot id: W0PEF3
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

1247726:MIM RS04215
gene id: 1247726:MIM_RS04215
uniprot id: W0P854
names: Similarity
messages: Belongs to the asparaginase 1 family.

1247726:MIM RS00290
gene id: 1247726:MIM_RS00290
uniprot id: W0P5X3
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

1247726:MIM RS02590
gene id: 1247726:MIM_RS02590
uniprot id: W0P6V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

1247726:MIM RS03935
gene id: 1247726:MIM_RS03935
uniprot id: W0P812
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS02570
gene id: 1247726:MIM_RS02570
uniprot id: W0PAZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1247726:MIM RS10105
gene id: 1247726:MIM_RS10105
uniprot id: W0PB92
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

1247726:MIM RS12200
gene id: 1247726:MIM_RS12200
uniprot id: W0PCD7
names: Similarity
messages: Belongs to the peptidase U62 family.

1247726:MIM RS07900
gene id: 1247726:MIM_RS07900
uniprot id: W0PDQ0
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS15805
gene id: 1247726:MIM_RS15805
uniprot id: W0PHZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS07935
gene id: 1247726:MIM_RS07935
uniprot id: W0PEU1
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1247726:MIM RS00185
gene id: 1247726:MIM_RS00185
uniprot id: W0P9N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS17035
gene id: 1247726:MIM_RS17035
uniprot id: W0PJY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1247726:MIM RS20855
gene id: 1247726:MIM_RS20855
uniprot id: R4JRJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1247726:MIM RS09660
gene id: 1247726:MIM_RS09660
uniprot id: W0PF55
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Involved in a late step of protoheme IX synthesis.
messages: Membrane

1247726:MIM RS13790
gene id: 1247726:MIM_RS13790
uniprot id: W0PD85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1247726:MIM RS06110
gene id: 1247726:MIM_RS06110
uniprot id: W0P8T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

1247726:MIM RS04170
gene id: 1247726:MIM_RS04170
uniprot id: W0PCZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS20010
gene id: 1247726:MIM_RS20010
uniprot id: W0PH65
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS01890
gene id: 1247726:MIM_RS01890
uniprot id: W0PAL9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS14890
gene id: 1247726:MIM_RS14890
uniprot id: W0PDF4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

1247726:MIM RS08885
gene id: 1247726:MIM_RS08885
uniprot id: W0PES6
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

1247726:MIM RS09245
gene id: 1247726:MIM_RS09245
uniprot id: W0PAS9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1247726:MIM RS03710
gene id: 1247726:MIM_RS03710
uniprot id: W0P7X5
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS02415
gene id: 1247726:MIM_RS02415
uniprot id: W0P6R8
names: Similarity
messages: Belongs to the SCO1/2 family.

1247726:MIM RS03630
gene id: 1247726:MIM_RS03630
uniprot id: W0PBL4
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1247726:MIM RS08335
gene id: 1247726:MIM_RS08335
uniprot id: W0PE09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

1247726:MIM RS08670
gene id: 1247726:MIM_RS08670
uniprot id: W0PF96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1247726:MIM RS18400
gene id: 1247726:MIM_RS18400
uniprot id: W0PEX4
names: Similarity
messages: Belongs to the OsmC/Ohr family.

1247726:MIM RS04630
gene id: 1247726:MIM_RS04630
uniprot id: W0P8C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

1247726:MIM RS08430
gene id: 1247726:MIM_RS08430
uniprot id: W0PE17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1247726:MIM RS04010
gene id: 1247726:MIM_RS04010
uniprot id: W0PBL7
names: Similarity
messages: Belongs to the peptidase S24 family.

1247726:MIM RS05310
gene id: 1247726:MIM_RS05310
uniprot id: W0PCB1
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

1247726:MIM RS07485
gene id: 1247726:MIM_RS07485
uniprot id: W0PDG9
names: Similarity
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.

1247726:MIM RS00080
gene id: 1247726:MIM_RS00080
uniprot id: W0P9L6
names: Similarity
messages: Belongs to the barstar family.

1247726:MIM RS02015
gene id: 1247726:MIM_RS02015
uniprot id: W0PAG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

1247726:MIM RS21180
gene id: 1247726:MIM_RS21180
uniprot id: W0PG83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1247726:MIM RS14945
gene id: 1247726:MIM_RS14945
uniprot id: W0PHI7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1247726:MIM RS02555
gene id: 1247726:MIM_RS02555
uniprot id: W0PAS0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

1247726:MIM RS01975
gene id: 1247726:MIM_RS01975
uniprot id: W0PAN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS01580
gene id: 1247726:MIM_RS01580
uniprot id: W0PA88
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1247726:MIM RS15710
gene id: 1247726:MIM_RS15710
uniprot id: W0PE52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1247726:MIM RS12685
gene id: 1247726:MIM_RS12685
uniprot id: W0PGQ7
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

1247726:MIM RS11620
gene id: 1247726:MIM_RS11620
uniprot id: W0PBQ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1247726:MIM RS21215
gene id: 1247726:MIM_RS21215
uniprot id: W0PHU5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS03415
gene id: 1247726:MIM_RS03415
uniprot id: W0PCL6
names: Function
names: Similarity
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family.
messages: In the N-terminal section; belongs to the proline dehydrogenase family.
messages: Oxidizes proline to glutamate for use as a carbon and nitrogen source.

1247726:MIM RS14580
gene id: 1247726:MIM_RS14580
uniprot id: W0PIQ2
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1247726:MIM RS10155
gene id: 1247726:MIM_RS10155
uniprot id: W0PB97
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

1247726:MIM RS04975
gene id: 1247726:MIM_RS04975
uniprot id: W0PC44
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS02910
gene id: 1247726:MIM_RS02910
uniprot id: W0P7E6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

1247726:MIM RS08620
gene id: 1247726:MIM_RS08620
uniprot id: W0PEP0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS14745
gene id: 1247726:MIM_RS14745
uniprot id: W0PHF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS12935
gene id: 1247726:MIM_RS12935
uniprot id: W0PHW6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1247726:MIM RS04075
gene id: 1247726:MIM_RS04075
uniprot id: W0P7Q5
names: Similarity
messages: Belongs to the DapA family.

1247726:MIM RS02025
gene id: 1247726:MIM_RS02025
uniprot id: W0P6J4
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1247726:MIM RS07840
gene id: 1247726:MIM_RS07840
uniprot id: W0PDS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

1247726:MIM RS10185
gene id: 1247726:MIM_RS10185
uniprot id: W0PEQ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1247726:MIM RS11380
gene id: 1247726:MIM_RS11380
uniprot id: W0PH48
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1247726:MIM RS17205
gene id: 1247726:MIM_RS17205
uniprot id: W0PEH8
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS06085
gene id: 1247726:MIM_RS06085
uniprot id: W0P8T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamE family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

1247726:MIM RS11260
gene id: 1247726:MIM_RS11260
uniprot id: W0PBZ5
names: Similarity
messages: Belongs to the thioredoxin family.

1247726:MIM RS01585
gene id: 1247726:MIM_RS01585
uniprot id: W0PBH7
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1247726:MIM RS12260
gene id: 1247726:MIM_RS12260
uniprot id: W0PHI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1247726:MIM RS04635
gene id: 1247726:MIM_RS04635
uniprot id: W0PBX7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS16410
gene id: 1247726:MIM_RS16410
uniprot id: W0PJN5
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS10940
gene id: 1247726:MIM_RS10940
uniprot id: W0PGB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS12295
gene id: 1247726:MIM_RS12295
uniprot id: W0PGM8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Cyclase 1 superfamily. KynB family.
messages: Binds 2 zinc ions per subunit.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
messages: Homodimer.

1247726:MIM RS10100
gene id: 1247726:MIM_RS10100
uniprot id: W0PFB6
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

1247726:MIM RS14115
gene id: 1247726:MIM_RS14115
uniprot id: W0PIJ1
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

1247726:MIM RS15740
gene id: 1247726:MIM_RS15740
uniprot id: W0PGV8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1247726:MIM RS05720
gene id: 1247726:MIM_RS05720
uniprot id: W0PCL4
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

1247726:MIM RS18745
gene id: 1247726:MIM_RS18745
uniprot id: W0PFY2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1247726:MIM RS17435
gene id: 1247726:MIM_RS17435
uniprot id: W0PEK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Cytoplasm

1247726:MIM RS07815
gene id: 1247726:MIM_RS07815
uniprot id: W0PDS7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1247726:MIM RS21465
gene id: 1247726:MIM_RS21465
uniprot id: W0PGB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1247726:MIM RS16165
gene id: 1247726:MIM_RS16165
uniprot id: W0PI69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS18860
gene id: 1247726:MIM_RS18860
uniprot id: W0PID1
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1247726:MIM RS05505
gene id: 1247726:MIM_RS05505
uniprot id: W0PCJ2
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS17700
gene id: 1247726:MIM_RS17700
uniprot id: W0PK99
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS07410
gene id: 1247726:MIM_RS07410
uniprot id: W0PEJ9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1247726:MIM RS06370
gene id: 1247726:MIM_RS06370
uniprot id: W0P8Y1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS09870
gene id: 1247726:MIM_RS09870
uniprot id: W0PF84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
messages: The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).

1247726:MIM RS20605
gene id: 1247726:MIM_RS20605
uniprot id: W0PG02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1247726:MIM RS00665
gene id: 1247726:MIM_RS00665
uniprot id: W0P9S9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS06205
gene id: 1247726:MIM_RS06205
uniprot id: W0PE26
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS03765
gene id: 1247726:MIM_RS03765
uniprot id: W0PBG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

1247726:MIM RS03040
gene id: 1247726:MIM_RS03040
uniprot id: W0P7K3
names: Similarity
messages: Belongs to the peptidase C40 family.

1247726:MIM RS15810
gene id: 1247726:MIM_RS15810
uniprot id: W0PE68
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1247726:MIM RS05320
gene id: 1247726:MIM_RS05320
uniprot id: W0P8D6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1247726:MIM RS21160
gene id: 1247726:MIM_RS21160
uniprot id: W0PKG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1247726:MIM RS13475
gene id: 1247726:MIM_RS13475
uniprot id: W0PGC5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1247726:MIM RS02845
gene id: 1247726:MIM_RS02845
uniprot id: W0P708
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: Homotetramer.
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

1247726:MIM RS06445
gene id: 1247726:MIM_RS06445
uniprot id: W0P8Z2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1247726:MIM RS07600
gene id: 1247726:MIM_RS07600
uniprot id: W0P9J4
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the RuBisCO large chain family. Type I subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterohexadecamer of 8 large chains and 8 small chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.
messages: The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'.

1247726:MIM RS04305
gene id: 1247726:MIM_RS04305
uniprot id: W0PD19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS03915
gene id: 1247726:MIM_RS03915
uniprot id: W0PBK1
names: Similarity
messages: Belongs to the TPP enzyme family.

1247726:MIM RS14360
gene id: 1247726:MIM_RS14360
uniprot id: W0PGJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family.
messages: Membrane

1247726:MIM RS14935
gene id: 1247726:MIM_RS14935
uniprot id: W0PIU9
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

1247726:MIM RS10765
gene id: 1247726:MIM_RS10765
uniprot id: W0PB83
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1247726:MIM RS18285
gene id: 1247726:MIM_RS18285
uniprot id: W0PI79
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS20090
gene id: 1247726:MIM_RS20090
uniprot id: W0PJX5
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

1247726:MIM RS14550
gene id: 1247726:MIM_RS14550
uniprot id: W0PGL8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: One is catalytic and the other provides a structural contribution.

1247726:MIM RS06525
gene id: 1247726:MIM_RS06525
uniprot id: W0PCX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS20615
gene id: 1247726:MIM_RS20615
uniprot id: W0PHF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1247726:MIM RS00405
gene id: 1247726:MIM_RS00405
uniprot id: W0PAV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS11680
gene id: 1247726:MIM_RS11680
uniprot id: W0PC59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1247726:MIM RS11120
gene id: 1247726:MIM_RS11120
uniprot id: W0PH09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS14640
gene id: 1247726:MIM_RS14640
uniprot id: W0PDA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ElaB/YgaM/YqjD family.
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS21725
gene id: 1247726:MIM_RS21725
uniprot id: W0PMC1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS08900
gene id: 1247726:MIM_RS08900
uniprot id: W0PFD4
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.
messages: Methylates ribosomal protein uL3 on a specific glutamine residue.

1247726:MIM RS14060
gene id: 1247726:MIM_RS14060
uniprot id: W0PII5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

1247726:MIM RS13860
gene id: 1247726:MIM_RS13860
uniprot id: W0PCW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS20980
gene id: 1247726:MIM_RS20980
uniprot id: W0PKD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1247726:MIM RS03775
gene id: 1247726:MIM_RS03775
uniprot id: W0P7K2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.

1247726:MIM RS19010
gene id: 1247726:MIM_RS19010
uniprot id: W0PKX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS12625
gene id: 1247726:MIM_RS12625
uniprot id: W0PC84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS09695
gene id: 1247726:MIM_RS09695
uniprot id: W0PEJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family. ParE type 1 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

1247726:MIM RS12880
gene id: 1247726:MIM_RS12880
uniprot id: W0PHV7
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

1247726:MIM RS10615
gene id: 1247726:MIM_RS10615
uniprot id: W0PBI4
names: Similarity
messages: Belongs to the PrpD family.

1247726:MIM RS01540
gene id: 1247726:MIM_RS01540
uniprot id: W0P6B0
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1247726:MIM RS20880
gene id: 1247726:MIM_RS20880
uniprot id: W0PHL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS05110
gene id: 1247726:MIM_RS05110
uniprot id: W0P897
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1247726:MIM RS18795
gene id: 1247726:MIM_RS18795
uniprot id: W0PFZ3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS03460
gene id: 1247726:MIM_RS03460
uniprot id: W0PCM4
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS18710
gene id: 1247726:MIM_RS18710
uniprot id: W0PJ41
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

1247726:MIM RS11005
gene id: 1247726:MIM_RS11005
uniprot id: W0PFY5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS15445
gene id: 1247726:MIM_RS15445
uniprot id: W0PHS3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1247726:MIM RS19270
gene id: 1247726:MIM_RS19270
uniprot id: W0PIF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1247726:MIM RS12380
gene id: 1247726:MIM_RS12380
uniprot id: W0PCG4
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

1247726:MIM RS01835
gene id: 1247726:MIM_RS01835
uniprot id: W0PAK9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1247726:MIM RS04625
gene id: 1247726:MIM_RS04625
uniprot id: W0PC46
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

1247726:MIM RS11010
gene id: 1247726:MIM_RS11010
uniprot id: W0PBS2
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

1247726:MIM RS05270
gene id: 1247726:MIM_RS05270
uniprot id: W0P8C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1247726:MIM RS06280
gene id: 1247726:MIM_RS06280
uniprot id: W0P998
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS12255
gene id: 1247726:MIM_RS12255
uniprot id: W0PFY9
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1247726:MIM RS17250
gene id: 1247726:MIM_RS17250
uniprot id: W0PK27
names: Similarity
messages: Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.

1247726:MIM RS13045
gene id: 1247726:MIM_RS13045
uniprot id: W0PG78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1247726:MIM RS16485
gene id: 1247726:MIM_RS16485
uniprot id: K4L7X3
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the conversion 3-sulfinopropanoyl-CoA (3SP-CoA) to propanoyl-CoA by abstraction of sulfite (PubMed:23354747, PubMed:26057676). Does not show dehydrogenase activity (PubMed:23354747). Involved in the degradation of 3,3'-dithiodipropionate (DTDP), a sulfur-containing precursor substrate for biosynthesis of polythioesters (PTEs) (PubMed:23354747).
messages: Deletion of the gene completely impairs growth on DTDP or 3-sulfinopropanoyl (3SP) as the sole carbon source.
messages: Does not catalyze the dehydrogenation of acyl-CoA thioesters (PubMed:23354747). The absence of dehydrogenase activity is most probably caused by the absence of a catalytic glutamate residue in either of the two positions conserved throughout the acyl-CoA dehydrogenase family (PubMed:23354747).
messages: Homotetramer.

1247726:MIM RS11935
gene id: 1247726:MIM_RS11935
uniprot id: W0PGK5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

1247726:MIM RS15245
gene id: 1247726:MIM_RS15245
uniprot id: W0PDW9
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS02470
gene id: 1247726:MIM_RS02470
uniprot id: W0PAY2
names: Similarity
messages: Belongs to the glutamate synthase family.

1247726:MIM RS06575
gene id: 1247726:MIM_RS06575
uniprot id: W0PCY9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1247726:MIM RS06880
gene id: 1247726:MIM_RS06880
uniprot id: W0PD98
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

1247726:MIM RS14175
gene id: 1247726:MIM_RS14175
uniprot id: W0PH61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1247726:MIM RS02525
gene id: 1247726:MIM_RS02525
uniprot id: W0P757
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

1247726:MIM RS15140
gene id: 1247726:MIM_RS15140
uniprot id: W0PDV0
names: Similarity
messages: Belongs to the IlvD/Edd family.

1247726:MIM RS17685
gene id: 1247726:MIM_RS17685
uniprot id: W0PIR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS08865
gene id: 1247726:MIM_RS08865
uniprot id: W0PAM2
names: Similarity
messages: Belongs to the TrpF family.

1247726:MIM RS01785
gene id: 1247726:MIM_RS01785
uniprot id: W0PAK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS06635
gene id: 1247726:MIM_RS06635
uniprot id: W0P922
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxH family.
messages: Binds 2 Mn(2+) ions per subunit in a binuclear metal center.
messages: Cell inner membrane
messages: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS10715
gene id: 1247726:MIM_RS10715
uniprot id: W0PFQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS12140
gene id: 1247726:MIM_RS12140
uniprot id: W0PBY4
names: Similarity
messages: Belongs to the glutamate synthase family.

1247726:MIM RS01230
gene id: 1247726:MIM_RS01230
uniprot id: W0PBB3
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS21745
gene id: 1247726:MIM_RS21745
uniprot id: W0PJF3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS08455
gene id: 1247726:MIM_RS08455
uniprot id: W0PE21
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS07755
gene id: 1247726:MIM_RS07755
uniprot id: W0P9M4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LptE lipoprotein family.
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.
messages: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.

1247726:MIM RS16715
gene id: 1247726:MIM_RS16715
uniprot id: W0PF26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS15755
gene id: 1247726:MIM_RS15755
uniprot id: W0PHY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1247726:MIM RS13675
gene id: 1247726:MIM_RS13675
uniprot id: W0PCQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1247726:MIM RS03870
gene id: 1247726:MIM_RS03870
uniprot id: W0PCT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1247726:MIM RS01690
gene id: 1247726:MIM_RS01690
uniprot id: W0PAB0
names: Caution
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

1247726:MIM RS09450
gene id: 1247726:MIM_RS09450
uniprot id: W0PFN5
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1247726:MIM RS00005
gene id: 1247726:MIM_RS00005
uniprot id: W0P5G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1247726:MIM RS02900
gene id: 1247726:MIM_RS02900
uniprot id: W0P719
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

1247726:MIM RS07595
gene id: 1247726:MIM_RS07595
uniprot id: W0PEN8
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the RuBisCO small chain family.
messages: Heterohexadecamer of 8 large and 8 small subunits.
messages: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. Although the small subunit is not catalytic it is essential for maximal activity.
messages: The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'.

1247726:MIM RS07780
gene id: 1247726:MIM_RS07780
uniprot id: W0PER6
names: Similarity
messages: Belongs to the LOG family.

1247726:MIM RS13650
gene id: 1247726:MIM_RS13650
uniprot id: W0PCP6
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

1247726:MIM RS03420
gene id: 1247726:MIM_RS03420
uniprot id: W0P7E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
messages: Cell inner membrane

1247726:MIM RS10150
gene id: 1247726:MIM_RS10150
uniprot id: W0PFC6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1247726:MIM RS07975
gene id: 1247726:MIM_RS07975
uniprot id: W0PA35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS11630
gene id: 1247726:MIM_RS11630
uniprot id: W0PC57
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1247726:MIM RS09625
gene id: 1247726:MIM_RS09625
uniprot id: W0PFR9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1247726:MIM RS14750
gene id: 1247726:MIM_RS14750
uniprot id: W0PDQ2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS15180
gene id: 1247726:MIM_RS15180
uniprot id: W0PDK5
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.

1247726:MIM RS11210
gene id: 1247726:MIM_RS11210
uniprot id: W0PBY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1247726:MIM RS10605
gene id: 1247726:MIM_RS10605
uniprot id: W0PB54
names: Similarity
messages: Belongs to the PrpD family.

1247726:MIM RS19020
gene id: 1247726:MIM_RS19020
uniprot id: W0PJA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1247726:MIM RS12875
gene id: 1247726:MIM_RS12875
uniprot id: W0PG63
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 75 kDa subunit family.
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1247726:MIM RS14160
gene id: 1247726:MIM_RS14160
uniprot id: W0PGH7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS01955
gene id: 1247726:MIM_RS01955
uniprot id: W0P6T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1247726:MIM RS08680
gene id: 1247726:MIM_RS08680
uniprot id: W0PEP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

1247726:MIM RS09105
gene id: 1247726:MIM_RS09105
uniprot id: W0PAR1
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS09375
gene id: 1247726:MIM_RS09375
uniprot id: W0PFM5
names: Function
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.

1247726:MIM RS10255
gene id: 1247726:MIM_RS10255
uniprot id: W0PBB6
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1247726:MIM RS08830
gene id: 1247726:MIM_RS08830
uniprot id: W0PER9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS05050
gene id: 1247726:MIM_RS05050
uniprot id: W0PC60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1247726:MIM RS11730
gene id: 1247726:MIM_RS11730
uniprot id: W0PC69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS11960
gene id: 1247726:MIM_RS11960
uniprot id: W0PBV6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

1247726:MIM RS16790
gene id: 1247726:MIM_RS16790
uniprot id: W0PEC7
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

1247726:MIM RS12670
gene id: 1247726:MIM_RS12670
uniprot id: W0PG40
names: Similarity
messages: Belongs to the RutC family.

1247726:MIM RS09805
gene id: 1247726:MIM_RS09805
uniprot id: W0PFV5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

1247726:MIM RS14920
gene id: 1247726:MIM_RS14920
uniprot id: W0PHI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1247726:MIM RS13245
gene id: 1247726:MIM_RS13245
uniprot id: W0PI40
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS04330
gene id: 1247726:MIM_RS04330
uniprot id: W0PD24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1247726:MIM RS12480
gene id: 1247726:MIM_RS12480
uniprot id: W0PGP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

1247726:MIM RS02510
gene id: 1247726:MIM_RS02510
uniprot id: W0PC02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS21005
gene id: 1247726:MIM_RS21005
uniprot id: W0PKD9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1247726:MIM RS10850
gene id: 1247726:MIM_RS10850
uniprot id: W0PBM6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS15510
gene id: 1247726:MIM_RS15510
uniprot id: W0PJ19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

1247726:MIM RS06935
gene id: 1247726:MIM_RS06935
uniprot id: W0PDB0
names: Similarity
messages: Belongs to the UPF0234 family.

1247726:MIM RS04645
gene id: 1247726:MIM_RS04645
uniprot id: W0P805
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS20060
gene id: 1247726:MIM_RS20060
uniprot id: W0PFR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS13690
gene id: 1247726:MIM_RS13690
uniprot id: W0PGE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein.
messages: Oligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.

1247726:MIM RS03010
gene id: 1247726:MIM_RS03010
uniprot id: W0P7J2
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

1247726:MIM RS12550
gene id: 1247726:MIM_RS12550
uniprot id: W0PC68
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1247726:MIM RS10035
gene id: 1247726:MIM_RS10035
uniprot id: W0PEN5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

1247726:MIM RS10820
gene id: 1247726:MIM_RS10820
uniprot id: W0PFS6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1247726:MIM RS02600
gene id: 1247726:MIM_RS02600
uniprot id: W0P776
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

1247726:MIM RS07690
gene id: 1247726:MIM_RS07690
uniprot id: W0P9Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

1247726:MIM RS11675
gene id: 1247726:MIM_RS11675
uniprot id: W0PGJ1
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

1247726:MIM RS13565
gene id: 1247726:MIM_RS13565
uniprot id: W0PI95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1247726:MIM RS19610
gene id: 1247726:MIM_RS19610
uniprot id: W0PLA9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1247726:MIM RS20035
gene id: 1247726:MIM_RS20035
uniprot id: W0PJW6
names: Similarity
messages: Belongs to the tannase family.

1247726:MIM RS18720
gene id: 1247726:MIM_RS18720
uniprot id: W0PIC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS10560
gene id: 1247726:MIM_RS10560
uniprot id: W0PFM2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS05220
gene id: 1247726:MIM_RS05220
uniprot id: W0P8B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

1247726:MIM RS20990
gene id: 1247726:MIM_RS20990
uniprot id: W0PJ31
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1247726:MIM RS10625
gene id: 1247726:MIM_RS10625
uniprot id: W0PG81
names: Similarity
messages: Belongs to the PrpD family.

1247726:MIM RS19995
gene id: 1247726:MIM_RS19995
uniprot id: W0PLI2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1247726:MIM RS20345
gene id: 1247726:MIM_RS20345
uniprot id: W0PFX0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1247726:MIM RS18965
gene id: 1247726:MIM_RS18965
uniprot id: W0PF53
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

1247726:MIM RS11995
gene id: 1247726:MIM_RS11995
uniprot id: W0PCA8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1247726:MIM RS11835
gene id: 1247726:MIM_RS11835
uniprot id: W0PC85
names: Caution
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS07335
gene id: 1247726:MIM_RS07335
uniprot id: W0PEJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS01795
gene id: 1247726:MIM_RS01795
uniprot id: W0PAC7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1247726:MIM RS01305
gene id: 1247726:MIM_RS01305
uniprot id: W0P662
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS07030
gene id: 1247726:MIM_RS07030
uniprot id: W0PEE9
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

1247726:MIM RS10205
gene id: 1247726:MIM_RS10205
uniprot id: W0PBA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

1247726:MIM RS03940
gene id: 1247726:MIM_RS03940
uniprot id: W0PBK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

1247726:MIM RS08695
gene id: 1247726:MIM_RS08695
uniprot id: W0PFA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1247726:MIM RS13040
gene id: 1247726:MIM_RS13040
uniprot id: W0PCS2
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

1247726:MIM RS18385
gene id: 1247726:MIM_RS18385
uniprot id: W0PFT7
names: Similarity
messages: Belongs to the VgrG protein family.

1247726:MIM RS15540
gene id: 1247726:MIM_RS15540
uniprot id: W0PDS1
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.

1247726:MIM RS13660
gene id: 1247726:MIM_RS13660
uniprot id: W0PD32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

1247726:MIM RS15520
gene id: 1247726:MIM_RS15520
uniprot id: W0PHT5
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS03265
gene id: 1247726:MIM_RS03265
uniprot id: W0PBE1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS10080
gene id: 1247726:MIM_RS10080
uniprot id: W0PB89
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1247726:MIM RS15555
gene id: 1247726:MIM_RS15555
uniprot id: W0PE19
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

1247726:MIM RS18835
gene id: 1247726:MIM_RS18835
uniprot id: W0PKU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS10645
gene id: 1247726:MIM_RS10645
uniprot id: W0PEY5
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS12890
gene id: 1247726:MIM_RS12890
uniprot id: W0PGS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1247726:MIM RS11970
gene id: 1247726:MIM_RS11970
uniprot id: W0PCA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapB family.
messages: Cell inner membrane
messages: Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.

1247726:MIM RS05385
gene id: 1247726:MIM_RS05385
uniprot id: W0PCI1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

1247726:MIM RS16005
gene id: 1247726:MIM_RS16005
uniprot id: W0PJD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS05885
gene id: 1247726:MIM_RS05885
uniprot id: W0P930
names: Similarity
messages: Belongs to the IlvD/Edd family.

1247726:MIM RS11715
gene id: 1247726:MIM_RS11715
uniprot id: W0PH92
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS22065
gene id: 1247726:MIM_RS22065
uniprot id: W0PDM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Cytoplasm

1247726:MIM RS00160
gene id: 1247726:MIM_RS00160
uniprot id: W0P9N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS10315
gene id: 1247726:MIM_RS10315
uniprot id: W0PET1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

1247726:MIM RS12225
gene id: 1247726:MIM_RS12225
uniprot id: W0PCE1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS17280
gene id: 1247726:MIM_RS17280
uniprot id: W0PEI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1247726:MIM RS16890
gene id: 1247726:MIM_RS16890
uniprot id: W0PF47
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

1247726:MIM RS21220
gene id: 1247726:MIM_RS21220
uniprot id: W0PJ70
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS19315
gene id: 1247726:MIM_RS19315
uniprot id: W0PGX9
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS10960
gene id: 1247726:MIM_RS10960
uniprot id: W0PBQ0
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1247726:MIM RS12300
gene id: 1247726:MIM_RS12300
uniprot id: W0PCF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Homodimer.

1247726:MIM RS00505
gene id: 1247726:MIM_RS00505
uniprot id: W0P9Q0
names: Similarity
messages: Belongs to the GST superfamily.

1247726:MIM RS12605
gene id: 1247726:MIM_RS12605
uniprot id: W0PGQ1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the MsrP family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

1247726:MIM RS14885
gene id: 1247726:MIM_RS14885
uniprot id: W0PIU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Periplasm

1247726:MIM RS11050
gene id: 1247726:MIM_RS11050
uniprot id: W0PBG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

1247726:MIM RS13815
gene id: 1247726:MIM_RS13815
uniprot id: W0PH19
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1247726:MIM RS14835
gene id: 1247726:MIM_RS14835
uniprot id: W0PIT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.

1247726:MIM RS02765
gene id: 1247726:MIM_RS02765
uniprot id: W0PC52
names: Similarity
messages: Belongs to the DEAD box helicase family.

1247726:MIM RS13200
gene id: 1247726:MIM_RS13200
uniprot id: W0PCH1
names: Similarity
messages: Belongs to the peptidase C59 family.

1247726:MIM RS19565
gene id: 1247726:MIM_RS19565
uniprot id: W0PFI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1247726:MIM RS14200
gene id: 1247726:MIM_RS14200
uniprot id: W0PH64
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1247726:MIM RS01395
gene id: 1247726:MIM_RS01395
uniprot id: W0PA51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS14915
gene id: 1247726:MIM_RS14915
uniprot id: W0PDG0
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1247726:MIM RS12030
gene id: 1247726:MIM_RS12030
uniprot id: W0PHD6
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

1247726:MIM RS09950
gene id: 1247726:MIM_RS09950
uniprot id: W0PF95
names: Similarity
messages: Belongs to the YicC/YloC family.

1247726:MIM RS17110
gene id: 1247726:MIM_RS17110
uniprot id: W0PF69
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

1247726:MIM RS14615
gene id: 1247726:MIM_RS14615
uniprot id: W0PHC7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1247726:MIM RS02425
gene id: 1247726:MIM_RS02425
uniprot id: W0P738
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

1247726:MIM RS19985
gene id: 1247726:MIM_RS19985
uniprot id: W0PH63
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1247726:MIM RS11650
gene id: 1247726:MIM_RS11650
uniprot id: W0PGI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1247726:MIM RS09940
gene id: 1247726:MIM_RS09940
uniprot id: W0PFX2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1247726:MIM RS00555
gene id: 1247726:MIM_RS00555
uniprot id: W0P650
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1247726:MIM RS17415
gene id: 1247726:MIM_RS17415
uniprot id: W0PIP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

1247726:MIM RS02685
gene id: 1247726:MIM_RS02685
uniprot id: W0PAU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

1247726:MIM RS01140
gene id: 1247726:MIM_RS01140
uniprot id: W0PA85
names: Similarity
messages: Belongs to the 2-oxoadipate dioxygenase/decarboxylase family.

1247726:MIM RS08165
gene id: 1247726:MIM_RS08165
uniprot id: W0PEX5
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

1247726:MIM RS09760
gene id: 1247726:MIM_RS09760
uniprot id: W0PF65
names: Similarity
messages: Belongs to the HesB/IscA family.

1247726:MIM RS10275
gene id: 1247726:MIM_RS10275
uniprot id: W0PFG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1247726:MIM RS21250
gene id: 1247726:MIM_RS21250
uniprot id: W0PJ75
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1247726:MIM RS11200
gene id: 1247726:MIM_RS11200
uniprot id: W0PBJ2
names: Similarity
messages: Belongs to the P(II) protein family.

1247726:MIM RS13265
gene id: 1247726:MIM_RS13265
uniprot id: W0PGA3
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

1247726:MIM RS15765
gene id: 1247726:MIM_RS15765
uniprot id: W0PGW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TolB family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: Periplasm
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1247726:MIM RS07605
gene id: 1247726:MIM_RS07605
uniprot id: W0PDN7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS01480
gene id: 1247726:MIM_RS01480
uniprot id: W0P698
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

1247726:MIM RS05960
gene id: 1247726:MIM_RS05960
uniprot id: W0PCU4
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS11555
gene id: 1247726:MIM_RS11555
uniprot id: W0PCL4
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

1247726:MIM RS06600
gene id: 1247726:MIM_RS06600
uniprot id: W0PCZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS04690
gene id: 1247726:MIM_RS04690
uniprot id: W0PBY7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1247726:MIM RS00725
gene id: 1247726:MIM_RS00725
uniprot id: W0P5W3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS18225
gene id: 1247726:MIM_RS18225
uniprot id: W0PFQ4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS14415
gene id: 1247726:MIM_RS14415
uniprot id: W0PIM5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1247726:MIM RS10970
gene id: 1247726:MIM_RS10970
uniprot id: W0PGC1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1247726:MIM RS16745
gene id: 1247726:MIM_RS16745
uniprot id: W0PHK5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS03205
gene id: 1247726:MIM_RS03205
uniprot id: W0P7A7
names: Similarity
messages: Belongs to the UPF0423 family.

1247726:MIM RS18135
gene id: 1247726:MIM_RS18135
uniprot id: W0PKG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS17195
gene id: 1247726:MIM_RS17195
uniprot id: W0PHS0
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

1247726:MIM RS10160
gene id: 1247726:MIM_RS10160
uniprot id: W0PEQ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1247726:MIM RS07065
gene id: 1247726:MIM_RS07065
uniprot id: W0PDD2
names: Function
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

1247726:MIM RS21785
gene id: 1247726:MIM_RS21785
uniprot id: W0PI30
names: Similarity
messages: Belongs to the peptidase S24 family.

1247726:MIM RS10210
gene id: 1247726:MIM_RS10210
uniprot id: W0PER4
names: Similarity
messages: Belongs to the Skp family.

1247726:MIM RS06570
gene id: 1247726:MIM_RS06570
uniprot id: W0P9E5
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1247726:MIM RS07560
gene id: 1247726:MIM_RS07560
uniprot id: W0P9V6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Gfa family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione.

1247726:MIM RS11045
gene id: 1247726:MIM_RS11045
uniprot id: W0PGZ8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1247726:MIM RS09455
gene id: 1247726:MIM_RS09455
uniprot id: W0PAJ8
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1247726:MIM RS04350
gene id: 1247726:MIM_RS04350
uniprot id: W0PBS9
names: Function
names: Similarity
messages: Belongs to the catalase family. HPII subfamily.
messages: Serves to protect cells from the toxic effects of hydrogen peroxide.

1247726:MIM RS12860
gene id: 1247726:MIM_RS12860
uniprot id: W0PCC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1247726:MIM RS08775
gene id: 1247726:MIM_RS08775
uniprot id: W0PA87
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1247726:MIM RS20380
gene id: 1247726:MIM_RS20380
uniprot id: W0PIU1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS17980
gene id: 1247726:MIM_RS17980
uniprot id: W0PFL3
names: Function
names: Similarity
messages: Belongs to the cyanase family.
messages: Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.

1247726:MIM RS06190
gene id: 1247726:MIM_RS06190
uniprot id: W0PCZ1
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1247726:MIM RS07660
gene id: 1247726:MIM_RS07660
uniprot id: W0P9X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1247726:MIM RS01040
gene id: 1247726:MIM_RS01040
uniprot id: W0PA68
names: Similarity
messages: Belongs to the leucine-binding protein family.

1247726:MIM RS04580
gene id: 1247726:MIM_RS04580
uniprot id: W0P8B7
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.

1247726:MIM RS10330
gene id: 1247726:MIM_RS10330
uniprot id: W0PFH3
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1247726:MIM RS02255
gene id: 1247726:MIM_RS02255
uniprot id: W0PAK7
names: Similarity
messages: Belongs to the PrpF family.

1247726:MIM RS05120
gene id: 1247726:MIM_RS05120
uniprot id: W0P8M1
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1247726:MIM RS06105
gene id: 1247726:MIM_RS06105
uniprot id: W0PE10
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

1247726:MIM RS06400
gene id: 1247726:MIM_RS06400
uniprot id: W0PD22
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

1247726:MIM RS06210
gene id: 1247726:MIM_RS06210
uniprot id: W0P8V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS12650
gene id: 1247726:MIM_RS12650
uniprot id: W0PHQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1247726:MIM RS08745
gene id: 1247726:MIM_RS08745
uniprot id: W0PFA6
names: Similarity
messages: Belongs to the pseudomonas-type ThrB family.

1247726:MIM RS13590
gene id: 1247726:MIM_RS13590
uniprot id: W0PGD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1247726:MIM RS11600
gene id: 1247726:MIM_RS11600
uniprot id: W0PGI4
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS04960
gene id: 1247726:MIM_RS04960
uniprot id: W0P864
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS11020
gene id: 1247726:MIM_RS11020
uniprot id: W0PGE9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1247726:MIM RS21035
gene id: 1247726:MIM_RS21035
uniprot id: W0PHP8
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS15370
gene id: 1247726:MIM_RS15370
uniprot id: W0PDY7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS11985
gene id: 1247726:MIM_RS11985
uniprot id: W0PBV8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

1247726:MIM RS09315
gene id: 1247726:MIM_RS09315
uniprot id: W0PEZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS11160
gene id: 1247726:MIM_RS11160
uniprot id: W0PBX9
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS21825
gene id: 1247726:MIM_RS21825
uniprot id: W0PGE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS13050
gene id: 1247726:MIM_RS13050
uniprot id: W0PHZ2
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

1247726:MIM RS14645
gene id: 1247726:MIM_RS14645
uniprot id: W0PHD3
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1247726:MIM RS11530
gene id: 1247726:MIM_RS11530
uniprot id: W0PC39
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

1247726:MIM RS19825
gene id: 1247726:MIM_RS19825
uniprot id: W0PJS7
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1247726:MIM RS18480
gene id: 1247726:MIM_RS18480
uniprot id: W0PJ05
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS07985
gene id: 1247726:MIM_RS07985
uniprot id: W0PEU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

1247726:MIM RS16655
gene id: 1247726:MIM_RS16655
uniprot id: W0PF15
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS02775
gene id: 1247726:MIM_RS02775
uniprot id: W0PB36
names: Similarity
messages: Belongs to the TrpC family.

1247726:MIM RS10365
gene id: 1247726:MIM_RS10365
uniprot id: W0PEU0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS20300
gene id: 1247726:MIM_RS20300
uniprot id: W0PHA3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS20515
gene id: 1247726:MIM_RS20515
uniprot id: W0PIV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

1247726:MIM RS13960
gene id: 1247726:MIM_RS13960
uniprot id: W0PIH3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1247726:MIM RS20640
gene id: 1247726:MIM_RS20640
uniprot id: W0PHF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1247726:MIM RS06385
gene id: 1247726:MIM_RS06385
uniprot id: W0PCU7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1247726:MIM RS04610
gene id: 1247726:MIM_RS04610
uniprot id: W0PBX2
names: Cofactor
messages: Binds 3 heme c groups covalently per subunit.

1247726:MIM RS07820
gene id: 1247726:MIM_RS07820
uniprot id: W0PA07
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

1247726:MIM RS15410
gene id: 1247726:MIM_RS15410
uniprot id: W0PDP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1247726:MIM RS06305
gene id: 1247726:MIM_RS06305
uniprot id: W0P9A3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1247726:MIM RS03875
gene id: 1247726:MIM_RS03875
uniprot id: W0P7M1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1247726:MIM RS04725
gene id: 1247726:MIM_RS04725
uniprot id: W0P817
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

1247726:MIM RS09290
gene id: 1247726:MIM_RS09290
uniprot id: W0PEY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS04415
gene id: 1247726:MIM_RS04415
uniprot id: W0PC07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS08460
gene id: 1247726:MIM_RS08460
uniprot id: W0PF80
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1247726:MIM RS08235
gene id: 1247726:MIM_RS08235
uniprot id: W0PDV1
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1247726:MIM RS05090
gene id: 1247726:MIM_RS05090
uniprot id: W0PCD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1247726:MIM RS14235
gene id: 1247726:MIM_RS14235
uniprot id: W0PGI8
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1247726:MIM RS04070
gene id: 1247726:MIM_RS04070
uniprot id: W0PCW9
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS09730
gene id: 1247726:MIM_RS09730
uniprot id: W0PAQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1247726:MIM RS07850
gene id: 1247726:MIM_RS07850
uniprot id: W0PDP1
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

1247726:MIM RS08820
gene id: 1247726:MIM_RS08820
uniprot id: W0PFB7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1247726:MIM RS01490
gene id: 1247726:MIM_RS01490
uniprot id: W0P6L3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the malate synthase family. GlcB subfamily.
messages: Cytoplasm
messages: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1247726:MIM RS12900
gene id: 1247726:MIM_RS12900
uniprot id: W0PG66
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1247726:MIM RS01315
gene id: 1247726:MIM_RS01315
uniprot id: W0P6I3
names: Similarity
messages: Belongs to the UPF0047 family.

1247726:MIM RS15035
gene id: 1247726:MIM_RS15035
uniprot id: W0PIW1
names: Similarity
messages: Belongs to the transglycosylase Slt family.

1247726:MIM RS02120
gene id: 1247726:MIM_RS02120
uniprot id: W0P6X0
names: Similarity
messages: Belongs to the MbcT/ParT/Res family.

1247726:MIM RS15950
gene id: 1247726:MIM_RS15950
uniprot id: W0PDZ5
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1247726:MIM RS10570
gene id: 1247726:MIM_RS10570
uniprot id: W0PEX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS17190
gene id: 1247726:MIM_RS17190
uniprot id: W0PF78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1247726:MIM RS21165
gene id: 1247726:MIM_RS21165
uniprot id: W0PHT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1247726:MIM RS16455
gene id: 1247726:MIM_RS16455
uniprot id: W0PHD9
names: Similarity
messages: Belongs to the PrpF family.

1247726:MIM RS21480
gene id: 1247726:MIM_RS21480
uniprot id: W0PJB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1247726:MIM RS04495
gene id: 1247726:MIM_RS04495
uniprot id: W0P8A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS20985
gene id: 1247726:MIM_RS20985
uniprot id: W0PHN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1247726:MIM RS06195
gene id: 1247726:MIM_RS06195
uniprot id: W0P985
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS15580
gene id: 1247726:MIM_RS15580
uniprot id: W0PE23
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1247726:MIM RS08125
gene id: 1247726:MIM_RS08125
uniprot id: W0PDX7
names: Similarity
messages: Belongs to the DSD1 family.

1247726:MIM RS12680
gene id: 1247726:MIM_RS12680
uniprot id: W0PC93
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1247726:MIM RS10915
gene id: 1247726:MIM_RS10915
uniprot id: W0PGB5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1247726:MIM RS01045
gene id: 1247726:MIM_RS01045
uniprot id: W0P6D3
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS02710
gene id: 1247726:MIM_RS02710
uniprot id: W0PAV0
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1247726:MIM RS10860
gene id: 1247726:MIM_RS10860
uniprot id: W0PGA8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1247726:MIM RS00970
gene id: 1247726:MIM_RS00970
uniprot id: W0P6C0
names: Similarity
messages: Belongs to the SIP oxidoreductase family.

1247726:MIM RS15800
gene id: 1247726:MIM_RS15800
uniprot id: W0PDX0
names: Similarity
messages: Belongs to the peptidase C56 family.

1247726:MIM RS10190
gene id: 1247726:MIM_RS10190
uniprot id: W0PG15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

1247726:MIM RS12315
gene id: 1247726:MIM_RS12315
uniprot id: W0PC16
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family.
messages: Part of the 50S ribosomal subunit.

1247726:MIM RS21075
gene id: 1247726:MIM_RS21075
uniprot id: W0PG70
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS09665
gene id: 1247726:MIM_RS09665
uniprot id: W0PB11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1247726:MIM RS10010
gene id: 1247726:MIM_RS10010
uniprot id: W0PEN2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS16560
gene id: 1247726:MIM_RS16560
uniprot id: W0PEZ9
names: Subcellular Location Annotation
messages: Periplasm

1247726:MIM RS19365
gene id: 1247726:MIM_RS19365
uniprot id: W0PGY4
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

1247726:MIM RS20630
gene id: 1247726:MIM_RS20630
uniprot id: W0PG06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1247726:MIM RS06300
gene id: 1247726:MIM_RS06300
uniprot id: W0PD07
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS01925
gene id: 1247726:MIM_RS01925
uniprot id: W0P6T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1247726:MIM RS17350
gene id: 1247726:MIM_RS17350
uniprot id: W0PK45
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

1247726:MIM RS13975
gene id: 1247726:MIM_RS13975
uniprot id: W0PDB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

1247726:MIM RS08355
gene id: 1247726:MIM_RS08355
uniprot id: W0PF18
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1247726:MIM RS09215
gene id: 1247726:MIM_RS09215
uniprot id: W0PEX2
names: Similarity
messages: Belongs to the DapA family.

1247726:MIM RS03785
gene id: 1247726:MIM_RS03785
uniprot id: W0P7Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS06750
gene id: 1247726:MIM_RS06750
uniprot id: W0P943
names: Similarity
messages: Belongs to the catalase family.

1247726:MIM RS11660
gene id: 1247726:MIM_RS11660
uniprot id: W0PFL0
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1247726:MIM RS04400
gene id: 1247726:MIM_RS04400
uniprot id: W0PBT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS12505
gene id: 1247726:MIM_RS12505
uniprot id: W0PGP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1247726:MIM RS12340
gene id: 1247726:MIM_RS12340
uniprot id: W0PC21
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1247726:MIM RS11015
gene id: 1247726:MIM_RS11015
uniprot id: W0PF74
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

1247726:MIM RS09320
gene id: 1247726:MIM_RS09320
uniprot id: W0PAU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS12815
gene id: 1247726:MIM_RS12815
uniprot id: W0PGR7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1247726:MIM RS01880
gene id: 1247726:MIM_RS01880
uniprot id: W0PBN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

1247726:MIM RS04815
gene id: 1247726:MIM_RS04815
uniprot id: W0P8G0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1247726:MIM RS04060
gene id: 1247726:MIM_RS04060
uniprot id: W0PBM5
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

1247726:MIM RS12745
gene id: 1247726:MIM_RS12745
uniprot id: W0PG48
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS13990
gene id: 1247726:MIM_RS13990
uniprot id: W0PCZ5
names: Cofactor
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.

1247726:MIM RS16405
gene id: 1247726:MIM_RS16405
uniprot id: W0PHC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS08215
gene id: 1247726:MIM_RS08215
uniprot id: W0PEY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS20425
gene id: 1247726:MIM_RS20425
uniprot id: W0PHC2
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

1247726:MIM RS15215
gene id: 1247726:MIM_RS15215
uniprot id: W0PHP4
names: Similarity
messages: Belongs to the SCO1/2 family.

1247726:MIM RS04445
gene id: 1247726:MIM_RS04445
uniprot id: W0P895
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS09140
gene id: 1247726:MIM_RS09140
uniprot id: W0PAR5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

1247726:MIM RS05895
gene id: 1247726:MIM_RS05895
uniprot id: W0PDX5
names: Cofactor
names: Similarity
messages: Belongs to the bacterial PQQ dehydrogenase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 1 PQQ group per subunit.

1247726:MIM RS09370
gene id: 1247726:MIM_RS09370
uniprot id: W0PEE7
names: Function
names: Similarity
messages: Belongs to the acetyltransferase family. EctA subfamily.
messages: Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A.

1247726:MIM RS16595
gene id: 1247726:MIM_RS16595
uniprot id: W0PF06
names: Similarity
messages: Belongs to the asparaginase 1 family.

1247726:MIM RS04135
gene id: 1247726:MIM_RS04135
uniprot id: W0P841
names: PTM
names: Subcellular Location Annotation
messages: Covalently binds the prosthetic group of malonate decarboxylase.
messages: Cytoplasm

1247726:MIM RS14575
gene id: 1247726:MIM_RS14575
uniprot id: W0PGM0
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1247726:MIM RS05075
gene id: 1247726:MIM_RS05075
uniprot id: W0PC67
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1247726:MIM RS19705
gene id: 1247726:MIM_RS19705
uniprot id: W0PIL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

1247726:MIM RS19040
gene id: 1247726:MIM_RS19040
uniprot id: W0PF67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS12010
gene id: 1247726:MIM_RS12010
uniprot id: W0PBW0
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

1247726:MIM RS10220
gene id: 1247726:MIM_RS10220
uniprot id: W0PAY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

1247726:MIM RS15155
gene id: 1247726:MIM_RS15155
uniprot id: W0PDK1
names: Similarity
messages: Belongs to the Rht family.

1247726:MIM RS01240
gene id: 1247726:MIM_RS01240
uniprot id: W0PAA2
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

1247726:MIM RS03605
gene id: 1247726:MIM_RS03605
uniprot id: W0PBK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1247726:MIM RS11580
gene id: 1247726:MIM_RS11580
uniprot id: W0PC49
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1247726:MIM RS12735
gene id: 1247726:MIM_RS12735
uniprot id: W0PGR1
names: Similarity
messages: Belongs to the BolA/IbaG family.

1247726:MIM RS16245
gene id: 1247726:MIM_RS16245
uniprot id: W0PI80
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS03195
gene id: 1247726:MIM_RS03195
uniprot id: W0PB70
names: Function
names: Similarity
messages: Belongs to the ribose 1,5-bisphosphokinase family.
messages: Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).

1247726:MIM RS02800
gene id: 1247726:MIM_RS02800
uniprot id: W0PB38
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1247726:MIM RS19590
gene id: 1247726:MIM_RS19590
uniprot id: W0PFI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm
messages: Homodimer.

1247726:MIM RS01910
gene id: 1247726:MIM_RS01910
uniprot id: W0P6H4
names: Similarity
messages: Belongs to the MbcT/ParT/Res family.

1247726:MIM RS20405
gene id: 1247726:MIM_RS20405
uniprot id: W0PIU4
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS16010
gene id: 1247726:MIM_RS16010
uniprot id: W0PE02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS10115
gene id: 1247726:MIM_RS10115
uniprot id: W0PG05
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

1247726:MIM RS19740
gene id: 1247726:MIM_RS19740
uniprot id: W0PLD4
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

1247726:MIM RS09430
gene id: 1247726:MIM_RS09430
uniprot id: W0PAJ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

1247726:MIM RS13880
gene id: 1247726:MIM_RS13880
uniprot id: W0PIG4
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1247726:MIM RS03895
gene id: 1247726:MIM_RS03895
uniprot id: W0PCT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1247726:MIM RS20485
gene id: 1247726:MIM_RS20485
uniprot id: W0PHD1
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS08710
gene id: 1247726:MIM_RS08710
uniprot id: W0PAJ9
names: Cofactor
messages: Can also use Mn(2+) ion.

1247726:MIM RS11150
gene id: 1247726:MIM_RS11150
uniprot id: W0PBI8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1247726:MIM RS16500
gene id: 1247726:MIM_RS16500
uniprot id: W0PEY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS04710
gene id: 1247726:MIM_RS04710
uniprot id: W0P8E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. MrdA subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall.
messages: Cell inner membrane

1247726:MIM RS15775
gene id: 1247726:MIM_RS15775
uniprot id: W0PDW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

1247726:MIM RS05635
gene id: 1247726:MIM_RS05635
uniprot id: W0PDQ4
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

1247726:MIM RS16230
gene id: 1247726:MIM_RS16230
uniprot id: W0PH24
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.

1247726:MIM RS01325
gene id: 1247726:MIM_RS01325
uniprot id: W0PBD0
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

1247726:MIM RS11490
gene id: 1247726:MIM_RS11490
uniprot id: W0PBN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiK family.
messages: Cytoplasm
messages: Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.

1247726:MIM RS04410
gene id: 1247726:MIM_RS04410
uniprot id: W0P7W4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS21020
gene id: 1247726:MIM_RS21020
uniprot id: W0PLZ3
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS10200
gene id: 1247726:MIM_RS10200
uniprot id: W0PFE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1247726:MIM RS12275
gene id: 1247726:MIM_RS12275
uniprot id: W0PCE8
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

1247726:MIM RS17705
gene id: 1247726:MIM_RS17705
uniprot id: W0PEN3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1247726:MIM RS13015
gene id: 1247726:MIM_RS13015
uniprot id: W0PCR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS05175
gene id: 1247726:MIM_RS05175
uniprot id: W0PCE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Homotrimer.

1247726:MIM RS12430
gene id: 1247726:MIM_RS12430
uniprot id: W0PGN6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1247726:MIM RS13255
gene id: 1247726:MIM_RS13255
uniprot id: W0PGU9
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS14600
gene id: 1247726:MIM_RS14600
uniprot id: W0PGM2
names: Similarity
messages: Belongs to the barstar family.

1247726:MIM RS02915
gene id: 1247726:MIM_RS02915
uniprot id: W0PAY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1247726:MIM RS07695
gene id: 1247726:MIM_RS07695
uniprot id: W0PDK9
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS08420
gene id: 1247726:MIM_RS08420
uniprot id: W0PEL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS20620
gene id: 1247726:MIM_RS20620
uniprot id: W0PIX1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1247726:MIM RS07245
gene id: 1247726:MIM_RS07245
uniprot id: W0PDG7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS09415
gene id: 1247726:MIM_RS09415
uniprot id: W0PAW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1247726:MIM RS21630
gene id: 1247726:MIM_RS21630
uniprot id: W0PI01
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS14475
gene id: 1247726:MIM_RS14475
uniprot id: W0PHA5
names: Similarity
messages: Belongs to the extradiol ring-cleavage dioxygenase family.

1247726:MIM RS09190
gene id: 1247726:MIM_RS09190
uniprot id: W0PEW8
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

1247726:MIM RS11175
gene id: 1247726:MIM_RS11175
uniprot id: W0PBJ0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1247726:MIM RS18510
gene id: 1247726:MIM_RS18510
uniprot id: W0PFV8
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

1247726:MIM RS14985
gene id: 1247726:MIM_RS14985
uniprot id: W0PIV4
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS17750
gene id: 1247726:MIM_RS17750
uniprot id: W0PIR9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS07585
gene id: 1247726:MIM_RS07585
uniprot id: W0P9W1
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS04395
gene id: 1247726:MIM_RS04395
uniprot id: W0P884
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS10425
gene id: 1247726:MIM_RS10425
uniprot id: W0PB16
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArsB family.
messages: Cell membrane
messages: Involved in arsenical resistance. Thought to form the channel of an arsenite pump.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1247726:MIM RS16170
gene id: 1247726:MIM_RS16170
uniprot id: W0PEB7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1247726:MIM RS17075
gene id: 1247726:MIM_RS17075
uniprot id: W0PIL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1247726:MIM RS15825
gene id: 1247726:MIM_RS15825
uniprot id: W0PDX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1247726:MIM RS11990
gene id: 1247726:MIM_RS11990
uniprot id: W0PGK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1247726:MIM RS19140
gene id: 1247726:MIM_RS19140
uniprot id: W0PF82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1247726:MIM RS03520
gene id: 1247726:MIM_RS03520
uniprot id: W0P7G2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

1247726:MIM RS18055
gene id: 1247726:MIM_RS18055
uniprot id: W0PIV6
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS08295
gene id: 1247726:MIM_RS08295
uniprot id: W0PDW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

1247726:MIM RS13785
gene id: 1247726:MIM_RS13785
uniprot id: W0PH16
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

1247726:MIM RS12855
gene id: 1247726:MIM_RS12855
uniprot id: W0PHV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1247726:MIM RS19085
gene id: 1247726:MIM_RS19085
uniprot id: W0PKZ1
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.

1247726:MIM RS12195
gene id: 1247726:MIM_RS12195
uniprot id: W0PGM3
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

1247726:MIM RS00515
gene id: 1247726:MIM_RS00515
uniprot id: W0P5T1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

1247726:MIM RS14165
gene id: 1247726:MIM_RS14165
uniprot id: W0PIJ3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS14080
gene id: 1247726:MIM_RS14080
uniprot id: W0PDD3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1247726:MIM RS13085
gene id: 1247726:MIM_RS13085
uniprot id: W0PCF5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1247726:MIM RS16100
gene id: 1247726:MIM_RS16100
uniprot id: W0PH01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: In the C-terminal section; belongs to the OsmX family.
messages: In the N-terminal section; belongs to the binding-protein-dependent transport system permease family.

1247726:MIM RS07995
gene id: 1247726:MIM_RS07995
uniprot id: W0PDV6
names: Function
names: Similarity
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.

1247726:MIM RS20000
gene id: 1247726:MIM_RS20000
uniprot id: W0PFQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS12730
gene id: 1247726:MIM_RS12730
uniprot id: W0PCA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YciB family.
messages: Cell inner membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.

1247726:MIM RS01825
gene id: 1247726:MIM_RS01825
uniprot id: W0PBM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family.
messages: Periplasm

1247726:MIM RS02315
gene id: 1247726:MIM_RS02315
uniprot id: W0P6P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1247726:MIM RS02595
gene id: 1247726:MIM_RS02595
uniprot id: W0PAZ9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

1247726:MIM RS11130
gene id: 1247726:MIM_RS11130
uniprot id: W0PGE6
names: Cofactor
names: Similarity
messages: Belongs to the nitroreductase family.
messages: Binds 1 FMN per subunit.

1247726:MIM RS00990
gene id: 1247726:MIM_RS00990
uniprot id: W0PA59
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS04940
gene id: 1247726:MIM_RS04940
uniprot id: W0PCA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

1247726:MIM RS08330
gene id: 1247726:MIM_RS08330
uniprot id: W0P9Y3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1247726:MIM RS04405
gene id: 1247726:MIM_RS04405
uniprot id: W0PD37
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1247726:MIM RS12915
gene id: 1247726:MIM_RS12915
uniprot id: W0PCL4
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

1247726:MIM RS06500
gene id: 1247726:MIM_RS06500
uniprot id: W0PCX0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1247726:MIM RS12750
gene id: 1247726:MIM_RS12750
uniprot id: W0PHT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZipA family.
messages: Cell inner membrane
messages: Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.

1247726:MIM RS08185
gene id: 1247726:MIM_RS08185
uniprot id: W0PDU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Membrane
messages: Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

1247726:MIM RS02905
gene id: 1247726:MIM_RS02905
uniprot id: W0PB50
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

1247726:MIM RS21400
gene id: 1247726:MIM_RS21400
uniprot id: W0PHX6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

1247726:MIM RS02455
gene id: 1247726:MIM_RS02455
uniprot id: W0PAQ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1247726:MIM RS11280
gene id: 1247726:MIM_RS11280
uniprot id: W0PGG7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

1247726:MIM RS19455
gene id: 1247726:MIM_RS19455
uniprot id: W0PL84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS10515
gene id: 1247726:MIM_RS10515
uniprot id: W0PEW4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1247726:MIM RS06765
gene id: 1247726:MIM_RS06765
uniprot id: W0PD31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS00310
gene id: 1247726:MIM_RS00310
uniprot id: W0P9R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS05065
gene id: 1247726:MIM_RS05065
uniprot id: W0PCC9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS01355
gene id: 1247726:MIM_RS01355
uniprot id: W0P674
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS05205
gene id: 1247726:MIM_RS05205
uniprot id: W0P8N7
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

1247726:MIM RS07170
gene id: 1247726:MIM_RS07170
uniprot id: W0P9N5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1247726:MIM RS09335
gene id: 1247726:MIM_RS09335
uniprot id: W0PAH4
names: Similarity
messages: Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family.

1247726:MIM RS14000
gene id: 1247726:MIM_RS14000
uniprot id: W0PDC1
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

1247726:MIM RS12545
gene id: 1247726:MIM_RS12545
uniprot id: W0PHM3
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

1247726:MIM RS15850
gene id: 1247726:MIM_RS15850
uniprot id: W0PDY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS08905
gene id: 1247726:MIM_RS08905
uniprot id: W0PAA9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

1247726:MIM RS10050
gene id: 1247726:MIM_RS10050
uniprot id: W0PFA7
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS08660
gene id: 1247726:MIM_RS08660
uniprot id: W0PAJ2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1247726:MIM RS00925
gene id: 1247726:MIM_RS00925
uniprot id: W0P9W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS00440
gene id: 1247726:MIM_RS00440
uniprot id: W0P5R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Membrane

1247726:MIM RS12795
gene id: 1247726:MIM_RS12795
uniprot id: W0PCN5
names: Function
names: Similarity
messages: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
messages: Belongs to the AhpD family.

1247726:MIM RS14860
gene id: 1247726:MIM_RS14860
uniprot id: W0PIU0
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS08705
gene id: 1247726:MIM_RS08705
uniprot id: W0PEQ2
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS06365
gene id: 1247726:MIM_RS06365
uniprot id: W0PE54
names: Similarity
messages: Belongs to the thioesterase PaaI family.

1247726:MIM RS18295
gene id: 1247726:MIM_RS18295
uniprot id: W0PEV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS17210
gene id: 1247726:MIM_RS17210
uniprot id: W0PIM8
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS06450
gene id: 1247726:MIM_RS06450
uniprot id: W0PD29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1247726:MIM RS13220
gene id: 1247726:MIM_RS13220
uniprot id: W0PI27
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS21255
gene id: 1247726:MIM_RS21255
uniprot id: W0PM42
names: Similarity
messages: Belongs to the GST superfamily.

1247726:MIM RS19820
gene id: 1247726:MIM_RS19820
uniprot id: W0PFM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS12725
gene id: 1247726:MIM_RS12725
uniprot id: W0PHS7
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

1247726:MIM RS00230
gene id: 1247726:MIM_RS00230
uniprot id: W0P5L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS20970
gene id: 1247726:MIM_RS20970
uniprot id: W0PLY1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1247726:MIM RS07955
gene id: 1247726:MIM_RS07955
uniprot id: W0PDR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. KdkA/RfaP family.
messages: Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position.
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS06135
gene id: 1247726:MIM_RS06135
uniprot id: W0P8U1
names: Similarity
messages: Belongs to the methylglyoxal synthase family.

1247726:MIM RS04565
gene id: 1247726:MIM_RS04565
uniprot id: W0P7Z2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1247726:MIM RS04640
gene id: 1247726:MIM_RS04640
uniprot id: W0PD74
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS15785
gene id: 1247726:MIM_RS15785
uniprot id: W0PE66
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS19800
gene id: 1247726:MIM_RS19800
uniprot id: W0PJS1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1247726:MIM RS06630
gene id: 1247726:MIM_RS06630
uniprot id: W0PE89
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1247726:MIM RS02465
gene id: 1247726:MIM_RS02465
uniprot id: W0P6S5
names: Similarity
messages: Belongs to the DEAD box helicase family.

1247726:MIM RS05030
gene id: 1247726:MIM_RS05030
uniprot id: W0PDF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1247726:MIM RS06140
gene id: 1247726:MIM_RS06140
uniprot id: W0PCX7
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

1247726:MIM RS02520
gene id: 1247726:MIM_RS02520
uniprot id: W0PAZ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS02385
gene id: 1247726:MIM_RS02385
uniprot id: W0PBX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS08605
gene id: 1247726:MIM_RS08605
uniprot id: W0PF91
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS03485
gene id: 1247726:MIM_RS03485
uniprot id: W0PBC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

1247726:MIM RS19160
gene id: 1247726:MIM_RS19160
uniprot id: W0PL15
names: Similarity
messages: Belongs to the pirin family.

1247726:MIM RS16465
gene id: 1247726:MIM_RS16465
uniprot id: W0PE95
names: Similarity
messages: Belongs to the citrate synthase family.

1247726:MIM RS11110
gene id: 1247726:MIM_RS11110
uniprot id: W0PBX0
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS16365
gene id: 1247726:MIM_RS16365
uniprot id: W0PE72
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS19265
gene id: 1247726:MIM_RS19265
uniprot id: W0PGX5
names: Caution
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS11885
gene id: 1247726:MIM_RS11885
uniprot id: W0PHB3
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS10520
gene id: 1247726:MIM_RS10520
uniprot id: W0PG68
names: Subunit
messages: Homodimer.

1247726:MIM RS11770
gene id: 1247726:MIM_RS11770
uniprot id: W0PH99
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1247726:MIM RS06940
gene id: 1247726:MIM_RS06940
uniprot id: W0P9J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1247726:MIM RS08760
gene id: 1247726:MIM_RS08760
uniprot id: W0PAK8
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1247726:MIM RS08700
gene id: 1247726:MIM_RS08700
uniprot id: W0PA75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1247726:MIM RS21115
gene id: 1247726:MIM_RS21115
uniprot id: W0PHR3
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

1247726:MIM RS21820
gene id: 1247726:MIM_RS21820
uniprot id: W0PMD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1247726:MIM RS01330
gene id: 1247726:MIM_RS01330
uniprot id: W0P667
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS01050
gene id: 1247726:MIM_RS01050
uniprot id: W0P9Y9
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS10910
gene id: 1247726:MIM_RS10910
uniprot id: W0PF33
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS02270
gene id: 1247726:MIM_RS02270
uniprot id: W0PAU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1247726:MIM RS21780
gene id: 1247726:MIM_RS21780
uniprot id: W0PKT3
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

1247726:MIM RS21835
gene id: 1247726:MIM_RS21835
uniprot id: W0PI42
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS01255
gene id: 1247726:MIM_RS01255
uniprot id: W0P652
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1247726:MIM RS07005
gene id: 1247726:MIM_RS07005
uniprot id: W0PEE6
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1247726:MIM RS15485
gene id: 1247726:MIM_RS15485
uniprot id: W0PJ13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1247726:MIM RS10555
gene id: 1247726:MIM_RS10555
uniprot id: W0PB39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS14760
gene id: 1247726:MIM_RS14760
uniprot id: W0PGN9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS02575
gene id: 1247726:MIM_RS02575
uniprot id: W0P768
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1247726:MIM RS04700
gene id: 1247726:MIM_RS04700
uniprot id: W0P814
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

1247726:MIM RS02550
gene id: 1247726:MIM_RS02550
uniprot id: W0P763
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1247726:MIM RS15230
gene id: 1247726:MIM_RS15230
uniprot id: W0PIX0
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1247726:MIM RS07570
gene id: 1247726:MIM_RS07570
uniprot id: W0PEM9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: One is catalytic and the other provides a structural contribution.

1247726:MIM RS20830
gene id: 1247726:MIM_RS20830
uniprot id: W0PHK8
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

1247726:MIM RS08305
gene id: 1247726:MIM_RS08305
uniprot id: W0P9X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1247726:MIM RS02410
gene id: 1247726:MIM_RS02410
uniprot id: W0PBY0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

1247726:MIM RS14345
gene id: 1247726:MIM_RS14345
uniprot id: W0PD57
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS01665
gene id: 1247726:MIM_RS01665
uniprot id: W0PAA5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

1247726:MIM RS10535
gene id: 1247726:MIM_RS10535
uniprot id: W0PBG9
names: Similarity
messages: Belongs to the DapA family.

1247726:MIM RS07315
gene id: 1247726:MIM_RS07315
uniprot id: W0P9E3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS14705
gene id: 1247726:MIM_RS14705
uniprot id: W0PGN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
messages: Cytoplasm
messages: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.

1247726:MIM RS03350
gene id: 1247726:MIM_RS03350
uniprot id: W0P7R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell inner membrane
messages: Membrane

1247726:MIM RS20340
gene id: 1247726:MIM_RS20340
uniprot id: W0PLN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1247726:MIM RS12850
gene id: 1247726:MIM_RS12850
uniprot id: W0PG60
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS06030
gene id: 1247726:MIM_RS06030
uniprot id: W0P8S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase bacterial subunit 4 family.
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

1247726:MIM RS15270
gene id: 1247726:MIM_RS15270
uniprot id: W0PDX3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

1247726:MIM RS20670
gene id: 1247726:MIM_RS20670
uniprot id: W0PIX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS02645
gene id: 1247726:MIM_RS02645
uniprot id: W0P6W3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.

1247726:MIM RS10995
gene id: 1247726:MIM_RS10995
uniprot id: W0PGC3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS14390
gene id: 1247726:MIM_RS14390
uniprot id: W0PIM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS02105
gene id: 1247726:MIM_RS02105
uniprot id: W0P6K9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS06530
gene id: 1247726:MIM_RS06530
uniprot id: W0PE76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS03890
gene id: 1247726:MIM_RS03890
uniprot id: W0PBJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1247726:MIM RS01095
gene id: 1247726:MIM_RS01095
uniprot id: W0P6E3
names: Similarity
messages: Belongs to the FrmR/RcnR family.

1247726:MIM RS10025
gene id: 1247726:MIM_RS10025
uniprot id: W0PFA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane
messages: Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

1247726:MIM RS20220
gene id: 1247726:MIM_RS20220
uniprot id: W0PJZ9
names: Similarity
messages: Belongs to the SIP oxidoreductase family.

1247726:MIM RS17040
gene id: 1247726:MIM_RS17040
uniprot id: W0PEF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1247726:MIM RS00060
gene id: 1247726:MIM_RS00060
uniprot id: W0P5Q7
names: Similarity
messages: Belongs to the protease inhibitor I11 (ecotin) family.

1247726:MIM RS06270
gene id: 1247726:MIM_RS06270
uniprot id: W0P8W1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS16225
gene id: 1247726:MIM_RS16225
uniprot id: W0PEC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS11515
gene id: 1247726:MIM_RS11515
uniprot id: W0PH62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

1247726:MIM RS04185
gene id: 1247726:MIM_RS04185
uniprot id: W0P850
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

1247726:MIM RS17870
gene id: 1247726:MIM_RS17870
uniprot id: W0PFH1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS14250
gene id: 1247726:MIM_RS14250
uniprot id: W0PH71
names: Subunit
messages: Homodimer.

1247726:MIM RS06035
gene id: 1247726:MIM_RS06035
uniprot id: W0PCV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

1247726:MIM RS07460
gene id: 1247726:MIM_RS07460
uniprot id: W0PEK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1247726:MIM RS21460
gene id: 1247726:MIM_RS21460
uniprot id: W0PM82
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1247726:MIM RS20235
gene id: 1247726:MIM_RS20235
uniprot id: W0PLL8
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1247726:MIM RS02605
gene id: 1247726:MIM_RS02605
uniprot id: W0PAT0
names: Cofactor
messages: Binds 1 heme c group covalently per subunit.

1247726:MIM RS02695
gene id: 1247726:MIM_RS02695
uniprot id: W0P6X4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

1247726:MIM RS11470
gene id: 1247726:MIM_RS11470
uniprot id: W0PGH9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1247726:MIM RS07825
gene id: 1247726:MIM_RS07825
uniprot id: W0PDN6
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

1247726:MIM RS04550
gene id: 1247726:MIM_RS04550
uniprot id: W0P8B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Periplasm

1247726:MIM RS20065
gene id: 1247726:MIM_RS20065
uniprot id: W0PJX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS09305
gene id: 1247726:MIM_RS09305
uniprot id: W0PFK9
names: Similarity
messages: Belongs to the TPP enzyme family.

1247726:MIM RS14230
gene id: 1247726:MIM_RS14230
uniprot id: W0PDF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1247726:MIM RS16855
gene id: 1247726:MIM_RS16855
uniprot id: W0PIK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1247726:MIM RS14930
gene id: 1247726:MIM_RS14930
uniprot id: W0PGQ0
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

1247726:MIM RS19850
gene id: 1247726:MIM_RS19850
uniprot id: W0PFM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS03830
gene id: 1247726:MIM_RS03830
uniprot id: W0PBQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Homodimer.

1247726:MIM RS19105
gene id: 1247726:MIM_RS19105
uniprot id: W0PIE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS08725
gene id: 1247726:MIM_RS08725
uniprot id: W0PA79
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

1247726:MIM RS09495
gene id: 1247726:MIM_RS09495
uniprot id: W0PEG3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1247726:MIM RS09380
gene id: 1247726:MIM_RS09380
uniprot id: W0PAI4
names: Function
names: Similarity
messages: Belongs to the ectoine synthase family.
messages: Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.

1247726:MIM RS21360
gene id: 1247726:MIM_RS21360
uniprot id: W0PM60
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

1247726:MIM RS01905
gene id: 1247726:MIM_RS01905
uniprot id: W0PBP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

1247726:MIM RS03175
gene id: 1247726:MIM_RS03175
uniprot id: W0PCI0
names: Function
names: Similarity
messages: Belongs to the PhnJ family.
messages: Catalyzes the breakage of the C-P bond in alpha-D-ribose 1-methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose.

1247726:MIM RS08855
gene id: 1247726:MIM_RS08855
uniprot id: W0PAA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1247726:MIM RS03215
gene id: 1247726:MIM_RS03215
uniprot id: W0P7N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

1247726:MIM RS06555
gene id: 1247726:MIM_RS06555
uniprot id: W0PE79
names: Function
names: Similarity
messages: Belongs to the AMP nucleosidase family.
messages: Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.

1247726:MIM RS13445
gene id: 1247726:MIM_RS13445
uniprot id: W0PCY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1247726:MIM RS00065
gene id: 1247726:MIM_RS00065
uniprot id: W0P9E4
names: Cofactor
names: Similarity
messages: Belongs to the bacterial PQQ dehydrogenase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 1 PQQ group per subunit.
messages: Binds 1 heme c group per subunit.

1247726:MIM RS20975
gene id: 1247726:MIM_RS20975
uniprot id: W0PG59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1247726:MIM RS05340
gene id: 1247726:MIM_RS05340
uniprot id: W0PCB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

1247726:MIM RS16015
gene id: 1247726:MIM_RS16015
uniprot id: W0PI41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1247726:MIM RS06395
gene id: 1247726:MIM_RS06395
uniprot id: W0P8Y5
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

1247726:MIM RS13295
gene id: 1247726:MIM_RS13295
uniprot id: W0PI49
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1247726:MIM RS07880
gene id: 1247726:MIM_RS07880
uniprot id: W0PET3
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

1247726:MIM RS21445
gene id: 1247726:MIM_RS21445
uniprot id: W0PKM4
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1247726:MIM RS09500
gene id: 1247726:MIM_RS09500
uniprot id: W0PFP3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1247726:MIM RS02275
gene id: 1247726:MIM_RS02275
uniprot id: W0P701
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS06230
gene id: 1247726:MIM_RS06230
uniprot id: W0PE31
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

1247726:MIM RS20150
gene id: 1247726:MIM_RS20150
uniprot id: W0PIS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1247726:MIM RS20565
gene id: 1247726:MIM_RS20565
uniprot id: W0PIW0
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS21450
gene id: 1247726:MIM_RS21450
uniprot id: W0PCL4
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

1247726:MIM RS20635
gene id: 1247726:MIM_RS20635
uniprot id: W0PK75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1247726:MIM RS10685
gene id: 1247726:MIM_RS10685
uniprot id: W0PB69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS20275
gene id: 1247726:MIM_RS20275
uniprot id: W0PHA0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS03900
gene id: 1247726:MIM_RS03900
uniprot id: W0P7M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1247726:MIM RS06640
gene id: 1247726:MIM_RS06640
uniprot id: W0PD59
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1247726:MIM RS07835
gene id: 1247726:MIM_RS07835
uniprot id: W0P9N7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PriB family.
messages: Binds single-stranded DNA at the primosome assembly site (PAS).
messages: Component of the preprimosomal complex composed of PriA, PriB, PriC, DnaB and DnaT. Upon transient interaction with DnaG it forms the primosome.

1247726:MIM RS22240
gene id: 1247726:MIM_RS22240
uniprot id: W0PIQ6
names: Similarity
messages: Belongs to the VgrG protein family.

1247726:MIM RS14910
gene id: 1247726:MIM_RS14910
uniprot id: W0PIU7
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS08160
gene id: 1247726:MIM_RS08160
uniprot id: W0PDT9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

1247726:MIM RS14970
gene id: 1247726:MIM_RS14970
uniprot id: W0PHK4
names: Similarity
messages: Belongs to the complex I 75 kDa subunit family.
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1247726:MIM RS07365
gene id: 1247726:MIM_RS07365
uniprot id: W0P9F2
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS10565
gene id: 1247726:MIM_RS10565
uniprot id: W0PBH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS06275
gene id: 1247726:MIM_RS06275
uniprot id: W0PD02
names: Similarity
messages: Belongs to the UPF0246 family.

1247726:MIM RS11920
gene id: 1247726:MIM_RS11920
uniprot id: W0PHB7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CcoP / FixP family.
messages: Binds 2 heme C groups per subunit.
messages: C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.
messages: Cell inner membrane
messages: Component of the cbb3-type cytochrome c oxidase.

1247726:MIM RS05060
gene id: 1247726:MIM_RS05060
uniprot id: W0P883
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. FtsW subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell division.

1247726:MIM RS08730
gene id: 1247726:MIM_RS08730
uniprot id: W0PEQ6
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

1247726:MIM RS21600
gene id: 1247726:MIM_RS21600
uniprot id: W0PKQ1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1247726:MIM RS07535
gene id: 1247726:MIM_RS07535
uniprot id: W0PDH9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. PqqE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
messages: Interacts with PqqD. The interaction is necessary for activity of PqqE.

1247726:MIM RS12415
gene id: 1247726:MIM_RS12415
uniprot id: W0PG12
names: Similarity
messages: Belongs to the UPF0751 family.

1247726:MIM RS03505
gene id: 1247726:MIM_RS03505
uniprot id: W0P7T9
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

1247726:MIM RS15000
gene id: 1247726:MIM_RS15000
uniprot id: W0PDT7
names: Similarity
messages: Belongs to the universal stress protein A family.

1247726:MIM RS05905
gene id: 1247726:MIM_RS05905
uniprot id: W0P8Q0
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1247726:MIM RS10250
gene id: 1247726:MIM_RS10250
uniprot id: W0PFF5
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.

1247726:MIM RS19145
gene id: 1247726:MIM_RS19145
uniprot id: W0PJD0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS17910
gene id: 1247726:MIM_RS17910
uniprot id: W0PKC8
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

1247726:MIM RS14950
gene id: 1247726:MIM_RS14950
uniprot id: W0PDT0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

1247726:MIM RS17905
gene id: 1247726:MIM_RS17905
uniprot id: W0PI32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein SsuA/TauA family.
messages: Periplasm

1247726:MIM RS09385
gene id: 1247726:MIM_RS09385
uniprot id: W0PF04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PhyH family. EctD subfamily.
messages: Homodimer.
messages: Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine.

1247726:MIM RS13010
gene id: 1247726:MIM_RS13010
uniprot id: W0PGT1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS17055
gene id: 1247726:MIM_RS17055
uniprot id: W0PF64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1247726:MIM RS09460
gene id: 1247726:MIM_RS09460
uniprot id: W0PF16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

1247726:MIM RS00640
gene id: 1247726:MIM_RS00640
uniprot id: W0PB17
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1247726:MIM RS14135
gene id: 1247726:MIM_RS14135
uniprot id: W0PGH5
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

1247726:MIM RS10055
gene id: 1247726:MIM_RS10055
uniprot id: W0PB84
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS06610
gene id: 1247726:MIM_RS06610
uniprot id: W0P918
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

1247726:MIM RS09115
gene id: 1247726:MIM_RS09115
uniprot id: W0PEA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1247726:MIM RS17160
gene id: 1247726:MIM_RS17160
uniprot id: W0PF75
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1247726:MIM RS08590
gene id: 1247726:MIM_RS08590
uniprot id: W0PEN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial secretin family.
messages: Homododecamer. Tetramer of trimer.
messages: Required for type IV pilus biogenesis and competence. Could function as a pore for exit of the pilus but also as a channel for entry of heme and antimicrobial agents and uptake of transforming DNA.

1247726:MIM RS18430
gene id: 1247726:MIM_RS18430
uniprot id: W0PJ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS05295
gene id: 1247726:MIM_RS05295
uniprot id: W0P8D1
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1247726:MIM RS08490
gene id: 1247726:MIM_RS08490
uniprot id: W0PF83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS13695
gene id: 1247726:MIM_RS13695
uniprot id: W0PIE6
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS03910
gene id: 1247726:MIM_RS03910
uniprot id: W0P807
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS06480
gene id: 1247726:MIM_RS06480
uniprot id: W0P8Z7
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS14680
gene id: 1247726:MIM_RS14680
uniprot id: W0PGN3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

1247726:MIM RS02165
gene id: 1247726:MIM_RS02165
uniprot id: W0PAR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

1247726:MIM RS14445
gene id: 1247726:MIM_RS14445
uniprot id: W0PD73
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS09930
gene id: 1247726:MIM_RS09930
uniprot id: W0PB57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1247726:MIM RS08190
gene id: 1247726:MIM_RS08190
uniprot id: W0PEY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

1247726:MIM RS03560
gene id: 1247726:MIM_RS03560
uniprot id: W0P7U8
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1247726:MIM RS02755
gene id: 1247726:MIM_RS02755
uniprot id: W0P7B0
names: Subcellular Location Annotation
messages: Membrane

1247726:MIM RS09440
gene id: 1247726:MIM_RS09440
uniprot id: W0PAW5
names: Similarity
messages: Belongs to the YfgM family.

1247726:MIM RS13595
gene id: 1247726:MIM_RS13595
uniprot id: W0PI98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1247726:MIM RS10595
gene id: 1247726:MIM_RS10595
uniprot id: W0PEX7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1247726:MIM RS21485
gene id: 1247726:MIM_RS21485
uniprot id: W0PM89
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1247726:MIM RS05095
gene id: 1247726:MIM_RS05095
uniprot id: W0P8L6
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

1247726:MIM RS18945
gene id: 1247726:MIM_RS18945
uniprot id: W0PG13
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1247726:MIM RS10340
gene id: 1247726:MIM_RS10340
uniprot id: W0PET4
names: Similarity
messages: Belongs to the GST superfamily.

1247726:MIM RS09000
gene id: 1247726:MIM_RS09000
uniprot id: W0PE87
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

1247726:MIM RS00830
gene id: 1247726:MIM_RS00830
uniprot id: W0P5Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS17025
gene id: 1247726:MIM_RS17025
uniprot id: W0PF61
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1247726:MIM RS08910
gene id: 1247726:MIM_RS08910
uniprot id: W0PET0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

1247726:MIM RS04490
gene id: 1247726:MIM_RS04490
uniprot id: W0PC23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1247726:MIM RS13795
gene id: 1247726:MIM_RS13795
uniprot id: W0PGF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS06660
gene id: 1247726:MIM_RS06660
uniprot id: W0P928
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1247726:MIM RS11115
gene id: 1247726:MIM_RS11115
uniprot id: W0PFD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

1247726:MIM RS17085
gene id: 1247726:MIM_RS17085
uniprot id: W0PHQ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).