1246995:AFR RS33535
gene id: 1246995:AFR_RS33535
uniprot id: U5WAG3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS13040
gene id: 1246995:AFR_RS13040
uniprot id: U5VYS2
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1246995:AFR RS37055
gene id: 1246995:AFR_RS37055
uniprot id: U5W8W5
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1246995:AFR RS38205
gene id: 1246995:AFR_RS38205
uniprot id: U5WD34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily.
messages: Periplasm

1246995:AFR RS40020
gene id: 1246995:AFR_RS40020
uniprot id: U5WAQ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Monomer.

1246995:AFR RS35875
gene id: 1246995:AFR_RS35875
uniprot id: U5WBM1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS00015
gene id: 1246995:AFR_RS00015
uniprot id: U5VNB3
names: Similarity
messages: Belongs to the 6-phosphogluconate dehydrogenase family.

1246995:AFR RS41230
gene id: 1246995:AFR_RS41230
uniprot id: U5WEI9
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

1246995:AFR RS25005
gene id: 1246995:AFR_RS25005
uniprot id: U5W1Y6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1246995:AFR RS37220
gene id: 1246995:AFR_RS37220
uniprot id: U5WCD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1246995:AFR RS23030
gene id: 1246995:AFR_RS23030
uniprot id: U5W4C8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS33680
gene id: 1246995:AFR_RS33680
uniprot id: U5W749
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS04315
gene id: 1246995:AFR_RS04315
uniprot id: U5VQN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1246995:AFR RS07220
gene id: 1246995:AFR_RS07220
uniprot id: U5VVP9
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS26660
gene id: 1246995:AFR_RS26660
uniprot id: U5W3I6
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1246995:AFR RS33400
gene id: 1246995:AFR_RS33400
uniprot id: U5W6S6
names: Similarity
messages: Belongs to the peptidase S1 family.

1246995:AFR RS16655
gene id: 1246995:AFR_RS16655
uniprot id: U5VXL9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS37450
gene id: 1246995:AFR_RS37450
uniprot id: U5WCQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

1246995:AFR RS27295
gene id: 1246995:AFR_RS27295
uniprot id: U5W6T9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS08120
gene id: 1246995:AFR_RS08120
uniprot id: U5VSV2
names: Similarity
messages: Belongs to the UPF0045 family.

1246995:AFR RS09215
gene id: 1246995:AFR_RS09215
uniprot id: U5VTD8
names: Similarity
messages: Belongs to the AfsR/DnrI/RedD regulatory family.

1246995:AFR RS10805
gene id: 1246995:AFR_RS10805
uniprot id: U5VXG8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1246995:AFR RS22585
gene id: 1246995:AFR_RS22585
uniprot id: U5W4B1
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

1246995:AFR RS10185
gene id: 1246995:AFR_RS10185
uniprot id: U5VTV5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1246995:AFR RS35855
gene id: 1246995:AFR_RS35855
uniprot id: U5WBQ4
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1246995:AFR RS25685
gene id: 1246995:AFR_RS25685
uniprot id: U5W2X7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arabinose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of L-arabinose to L-ribulose.

1246995:AFR RS40060
gene id: 1246995:AFR_RS40060
uniprot id: U5WB60
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase class-III family.

1246995:AFR RS37360
gene id: 1246995:AFR_RS37360
uniprot id: U5W920
names: Subunit
messages: Heterodimer of an alpha and a beta chain.

1246995:AFR RS30760
gene id: 1246995:AFR_RS30760
uniprot id: U5W5U4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

1246995:AFR RS47550
gene id: 1246995:AFR_RS47550
uniprot id: U5W9X4
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1246995:AFR RS03065
gene id: 1246995:AFR_RS03065
uniprot id: U5VTA4
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

1246995:AFR RS17175
gene id: 1246995:AFR_RS17175
uniprot id: U5W1B3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS11275
gene id: 1246995:AFR_RS11275
uniprot id: U5VUH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurD2 subfamily.
messages: Cell wall formation. Catalyzes the addition of L-glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine.
messages: Cytoplasm

1246995:AFR RS25110
gene id: 1246995:AFR_RS25110
uniprot id: U5W2A1
names: Similarity
messages: Belongs to the universal stress protein A family.

1246995:AFR RS09545
gene id: 1246995:AFR_RS09545
uniprot id: U5VWT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Cell membrane
messages: Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.

1246995:AFR RS07685
gene id: 1246995:AFR_RS07685
uniprot id: U5VVQ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1246995:AFR RS13525
gene id: 1246995:AFR_RS13525
uniprot id: U5VVE0
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

1246995:AFR RS04585
gene id: 1246995:AFR_RS04585
uniprot id: U5VU07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1246995:AFR RS11145
gene id: 1246995:AFR_RS11145
uniprot id: U5VU24
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

1246995:AFR RS39420
gene id: 1246995:AFR_RS39420
uniprot id: U5WAG1
names: Similarity
messages: Belongs to the FBPase class 2 family.

1246995:AFR RS07390
gene id: 1246995:AFR_RS07390
uniprot id: U5VSB3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1246995:AFR RS10700
gene id: 1246995:AFR_RS10700
uniprot id: U5VU61
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS24225
gene id: 1246995:AFR_RS24225
uniprot id: U5W1V7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS39485
gene id: 1246995:AFR_RS39485
uniprot id: U5WAA3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS19575
gene id: 1246995:AFR_RS19575
uniprot id: U5VZF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS39865
gene id: 1246995:AFR_RS39865
uniprot id: U5WDU2
names: Similarity
messages: Belongs to the glycosyl hydrolase 51 family.

1246995:AFR RS38765
gene id: 1246995:AFR_RS38765
uniprot id: U5WAB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta sliding clamp family.
messages: Cytoplasm

1246995:AFR RS43215
gene id: 1246995:AFR_RS43215
uniprot id: U5WFX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1246995:AFR RS19055
gene id: 1246995:AFR_RS19055
uniprot id: U5VYX7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS40365
gene id: 1246995:AFR_RS40365
uniprot id: U5WAP7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1246995:AFR RS26635
gene id: 1246995:AFR_RS26635
uniprot id: U5W3I2
names: Similarity
messages: Belongs to the AHA1 family.

1246995:AFR RS31060
gene id: 1246995:AFR_RS31060
uniprot id: U5W601
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1246995:AFR RS11160
gene id: 1246995:AFR_RS11160
uniprot id: U5VXV3
names: Cofactor
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Divalent metal ions. Mg(2+) is the most effective.

1246995:AFR RS36545
gene id: 1246995:AFR_RS36545
uniprot id: U5WC10
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1246995:AFR RS07715
gene id: 1246995:AFR_RS07715
uniprot id: U5VVY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1246995:AFR RS04625
gene id: 1246995:AFR_RS04625
uniprot id: U5VQH8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1246995:AFR RS00575
gene id: 1246995:AFR_RS00575
uniprot id: U5VNM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1246995:AFR RS01680
gene id: 1246995:AFR_RS01680
uniprot id: U5VSD1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

1246995:AFR RS39825
gene id: 1246995:AFR_RS39825
uniprot id: U5WB12
names: Similarity
messages: Belongs to the AHA1 family.

1246995:AFR RS33775
gene id: 1246995:AFR_RS33775
uniprot id: U5W706
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1246995:AFR RS18830
gene id: 1246995:AFR_RS18830
uniprot id: U5VYF1
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

1246995:AFR RS09335
gene id: 1246995:AFR_RS09335
uniprot id: U5VT46
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS30615
gene id: 1246995:AFR_RS30615
uniprot id: U5W555
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

1246995:AFR RS02495
gene id: 1246995:AFR_RS02495
uniprot id: U5VPN9
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS05985
gene id: 1246995:AFR_RS05985
uniprot id: U5VUZ0
names: Similarity
messages: Belongs to the AfsR/DnrI/RedD regulatory family.

1246995:AFR RS33500
gene id: 1246995:AFR_RS33500
uniprot id: U5W6U7
names: Similarity
messages: Belongs to the YggT family.

1246995:AFR RS10670
gene id: 1246995:AFR_RS10670
uniprot id: U5VTS5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

1246995:AFR RS43080
gene id: 1246995:AFR_RS43080
uniprot id: U5WFK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

1246995:AFR RS34080
gene id: 1246995:AFR_RS34080
uniprot id: U5W7F0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1246995:AFR RS40970
gene id: 1246995:AFR_RS40970
uniprot id: U5WB15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1246995:AFR RS11825
gene id: 1246995:AFR_RS11825
uniprot id: U5VUV9
names: Similarity
messages: Belongs to the FemABX family.

1246995:AFR RS01800
gene id: 1246995:AFR_RS01800
uniprot id: U5VPB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

1246995:AFR RS07500
gene id: 1246995:AFR_RS07500
uniprot id: U5VSH9
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group II subfamily.

1246995:AFR RS37535
gene id: 1246995:AFR_RS37535
uniprot id: U5W950
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1246995:AFR RS41555
gene id: 1246995:AFR_RS41555
uniprot id: U5WBE0
names: Similarity
messages: Belongs to the Nth/MutY family.

1246995:AFR RS05825
gene id: 1246995:AFR_RS05825
uniprot id: U5VUW1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DyP-type peroxidase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.
messages: Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.

1246995:AFR RS33090
gene id: 1246995:AFR_RS33090
uniprot id: U5WA35
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

1246995:AFR RS06745
gene id: 1246995:AFR_RS06745
uniprot id: U5VV91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

1246995:AFR RS10875
gene id: 1246995:AFR_RS10875
uniprot id: U5VU92
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS14550
gene id: 1246995:AFR_RS14550
uniprot id: U5VWE0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS29000
gene id: 1246995:AFR_RS29000
uniprot id: U5W7X0
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS16025
gene id: 1246995:AFR_RS16025
uniprot id: U5W0F9
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

1246995:AFR RS38105
gene id: 1246995:AFR_RS38105
uniprot id: U5WD17
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

1246995:AFR RS38860
gene id: 1246995:AFR_RS38860
uniprot id: U5WDG0
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS10135
gene id: 1246995:AFR_RS10135
uniprot id: U5VX42
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1246995:AFR RS30605
gene id: 1246995:AFR_RS30605
uniprot id: U5W8T1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1246995:AFR RS37685
gene id: 1246995:AFR_RS37685
uniprot id: U5W974
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1246995:AFR RS08210
gene id: 1246995:AFR_RS08210
uniprot id: U5VW72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

1246995:AFR RS36025
gene id: 1246995:AFR_RS36025
uniprot id: U5WBP5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1246995:AFR RS10405
gene id: 1246995:AFR_RS10405
uniprot id: U5VX94
names: Similarity
messages: Belongs to the TrpC family.

1246995:AFR RS37285
gene id: 1246995:AFR_RS37285
uniprot id: U5W908
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1246995:AFR RS39940
gene id: 1246995:AFR_RS39940
uniprot id: U5WAP0
names: Similarity
messages: Belongs to the peptidase S33 family.

1246995:AFR RS07425
gene id: 1246995:AFR_RS07425
uniprot id: U5VVT5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS01515
gene id: 1246995:AFR_RS01515
uniprot id: U5VP57
names: Similarity
messages: Belongs to the peptidase C40 family.

1246995:AFR RS14880
gene id: 1246995:AFR_RS14880
uniprot id: U5VZU4
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS09710
gene id: 1246995:AFR_RS09710
uniprot id: U5VTL9
names: Caution
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS02925
gene id: 1246995:AFR_RS02925
uniprot id: U5VPY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS09000
gene id: 1246995:AFR_RS09000
uniprot id: U5VWJ7
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

1246995:AFR RS33925
gene id: 1246995:AFR_RS33925
uniprot id: U5W739
names: Similarity
messages: Belongs to the CFA/CMAS family.

1246995:AFR RS38340
gene id: 1246995:AFR_RS38340
uniprot id: U5W9R4
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1246995:AFR RS35140
gene id: 1246995:AFR_RS35140
uniprot id: U5W7R8
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

1246995:AFR RS04695
gene id: 1246995:AFR_RS04695
uniprot id: U5VQY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1246995:AFR RS39025
gene id: 1246995:AFR_RS39025
uniprot id: U5WA46
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

1246995:AFR RS04325
gene id: 1246995:AFR_RS04325
uniprot id: U5VU47
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS40780
gene id: 1246995:AFR_RS40780
uniprot id: U5WEB0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

1246995:AFR RS42100
gene id: 1246995:AFR_RS42100
uniprot id: U5WF30
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

1246995:AFR RS24065
gene id: 1246995:AFR_RS24065
uniprot id: U5W232
names: Similarity
messages: Belongs to the YciI family.

1246995:AFR RS23330
gene id: 1246995:AFR_RS23330
uniprot id: U5W185
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS16860
gene id: 1246995:AFR_RS16860
uniprot id: U5VXD7
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS31015
gene id: 1246995:AFR_RS31015
uniprot id: U5W5E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS36240
gene id: 1246995:AFR_RS36240
uniprot id: U5W8D1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS08295
gene id: 1246995:AFR_RS08295
uniprot id: U5VSF4
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS20325
gene id: 1246995:AFR_RS20325
uniprot id: U5VZ88
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1246995:AFR RS23980
gene id: 1246995:AFR_RS23980
uniprot id: U5W4X4
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1246995:AFR RS07330
gene id: 1246995:AFR_RS07330
uniprot id: U5VSE6
names: Similarity
messages: Belongs to the YciI family.

1246995:AFR RS24275
gene id: 1246995:AFR_RS24275
uniprot id: U5W1W6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS31625
gene id: 1246995:AFR_RS31625
uniprot id: U5W6E4
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

1246995:AFR RS19700
gene id: 1246995:AFR_RS19700
uniprot id: U5VZH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1246995:AFR RS36155
gene id: 1246995:AFR_RS36155
uniprot id: U5WBW6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1246995:AFR RS41590
gene id: 1246995:AFR_RS41590
uniprot id: U5WER2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
messages: Cytoplasm

1246995:AFR RS09815
gene id: 1246995:AFR_RS09815
uniprot id: U5VWY7
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS31340
gene id: 1246995:AFR_RS31340
uniprot id: U5W5T0
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

1246995:AFR RS09375
gene id: 1246995:AFR_RS09375
uniprot id: U5VWX6
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1246995:AFR RS30610
gene id: 1246995:AFR_RS30610
uniprot id: U5W5R7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1246995:AFR RS02885
gene id: 1246995:AFR_RS02885
uniprot id: U5VT74
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1246995:AFR RS12000
gene id: 1246995:AFR_RS12000
uniprot id: U5VUM1
names: Similarity
messages: Belongs to the peptidase S33 family.

1246995:AFR RS06095
gene id: 1246995:AFR_RS06095
uniprot id: U5VR93
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1246995:AFR RS37170
gene id: 1246995:AFR_RS37170
uniprot id: U5WCC6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1246995:AFR RS22890
gene id: 1246995:AFR_RS22890
uniprot id: U5W1C5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1246995:AFR RS30940
gene id: 1246995:AFR_RS30940
uniprot id: U5W5C6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS25725
gene id: 1246995:AFR_RS25725
uniprot id: U5W5V6
names: Similarity
messages: Belongs to the pirin family.

1246995:AFR RS37615
gene id: 1246995:AFR_RS37615
uniprot id: U5W9C0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1246995:AFR RS01250
gene id: 1246995:AFR_RS01250
uniprot id: U5VP12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

1246995:AFR RS30785
gene id: 1246995:AFR_RS30785
uniprot id: U5W5U9
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

1246995:AFR RS24380
gene id: 1246995:AFR_RS24380
uniprot id: U5W564
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS10220
gene id: 1246995:AFR_RS10220
uniprot id: U5VXC6
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1246995:AFR RS14120
gene id: 1246995:AFR_RS14120
uniprot id: U5VZM3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS41010
gene id: 1246995:AFR_RS41010
uniprot id: U5WEP2
names: Similarity
names: Subunit
messages: Belongs to the sigma-70 factor family. ECF subfamily.
messages: Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.

1246995:AFR RS03265
gene id: 1246995:AFR_RS03265
uniprot id: U5VPP3
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS39850
gene id: 1246995:AFR_RS39850
uniprot id: U5WB17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS13945
gene id: 1246995:AFR_RS13945
uniprot id: U5VZJ0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS13010
gene id: 1246995:AFR_RS13010
uniprot id: U5VVH1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS00540
gene id: 1246995:AFR_RS00540
uniprot id: U5VRN8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1246995:AFR RS22900
gene id: 1246995:AFR_RS22900
uniprot id: U5W0Z7
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1246995:AFR RS35640
gene id: 1246995:AFR_RS35640
uniprot id: U5W803
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS19695
gene id: 1246995:AFR_RS19695
uniprot id: U5W2P0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1246995:AFR RS04850
gene id: 1246995:AFR_RS04850
uniprot id: U5VQL4
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1246995:AFR RS39175
gene id: 1246995:AFR_RS39175
uniprot id: U5WAB1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1246995:AFR RS31120
gene id: 1246995:AFR_RS31120
uniprot id: U5W5N7
names: Similarity
messages: Belongs to the thioesterase PaaI family.

1246995:AFR RS42140
gene id: 1246995:AFR_RS42140
uniprot id: U5WBZ1
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

1246995:AFR RS20050
gene id: 1246995:AFR_RS20050
uniprot id: U5VZ43
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS35835
gene id: 1246995:AFR_RS35835
uniprot id: U5W8P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1246995:AFR RS39005
gene id: 1246995:AFR_RS39005
uniprot id: U5WDB7
names: Similarity
messages: Belongs to the peptidase U62 family.

1246995:AFR RS34930
gene id: 1246995:AFR_RS34930
uniprot id: U5W873
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1246995:AFR RS13575
gene id: 1246995:AFR_RS13575
uniprot id: U5VVF2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS16225
gene id: 1246995:AFR_RS16225
uniprot id: U5VXA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1246995:AFR RS41640
gene id: 1246995:AFR_RS41640
uniprot id: U5WEW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS37965
gene id: 1246995:AFR_RS37965
uniprot id: U5W9C3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS14050
gene id: 1246995:AFR_RS14050
uniprot id: U5VWD3
names: Similarity
messages: Belongs to the F420H(2)-dependent quinone reductase family.

1246995:AFR RS23380
gene id: 1246995:AFR_RS23380
uniprot id: U5W196
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

1246995:AFR RS14360
gene id: 1246995:AFR_RS14360
uniprot id: U5VZR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

1246995:AFR RS21290
gene id: 1246995:AFR_RS21290
uniprot id: U5W3I0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS07115
gene id: 1246995:AFR_RS07115
uniprot id: U5VS64
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

1246995:AFR RS33230
gene id: 1246995:AFR_RS33230
uniprot id: U5W6U9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS03490
gene id: 1246995:AFR_RS03490
uniprot id: U5VPU2
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS19480
gene id: 1246995:AFR_RS19480
uniprot id: U5VYU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS16100
gene id: 1246995:AFR_RS16100
uniprot id: U5W0H3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1246995:AFR RS22540
gene id: 1246995:AFR_RS22540
uniprot id: U5W158
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS01930
gene id: 1246995:AFR_RS01930
uniprot id: U5VSH8
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1246995:AFR RS22225
gene id: 1246995:AFR_RS22225
uniprot id: U5W0N6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1246995:AFR RS36090
gene id: 1246995:AFR_RS36090
uniprot id: U5W8A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1246995:AFR RS01395
gene id: 1246995:AFR_RS01395
uniprot id: U5VNQ5
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS17760
gene id: 1246995:AFR_RS17760
uniprot id: U5VYE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS42605
gene id: 1246995:AFR_RS42605
uniprot id: U5WFB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EccB family.
messages: Membrane

1246995:AFR RS34715
gene id: 1246995:AFR_RS34715
uniprot id: U5WB54
names: Similarity
messages: Belongs to the peptidase S8 family.

1246995:AFR RS29405
gene id: 1246995:AFR_RS29405
uniprot id: U5W4J1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1246995:AFR RS41370
gene id: 1246995:AFR_RS41370
uniprot id: U5WBW5
names: Function
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: May catalyze the transamination reaction in phenylalanine biosynthesis.

1246995:AFR RS31680
gene id: 1246995:AFR_RS31680
uniprot id: U5W5X5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: Homotetramer.

1246995:AFR RS04600
gene id: 1246995:AFR_RS04600
uniprot id: U5VQH5
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1246995:AFR RS33915
gene id: 1246995:AFR_RS33915
uniprot id: U5WAN1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS07465
gene id: 1246995:AFR_RS07465
uniprot id: U5VVM5
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

1246995:AFR RS40160
gene id: 1246995:AFR_RS40160
uniprot id: U5WE93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS20435
gene id: 1246995:AFR_RS20435
uniprot id: U5W2V8
names: Function
names: Similarity
messages: Belongs to the Stf0 sulfotransferase family.
messages: Catalyzes the sulfuryl group transfer from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to trehalose, leading to trehalose-2-sulfate (T2S).

1246995:AFR RS10765
gene id: 1246995:AFR_RS10765
uniprot id: U5VUC4
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1246995:AFR RS25585
gene id: 1246995:AFR_RS25585
uniprot id: U5W2V9
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1246995:AFR RS18545
gene id: 1246995:AFR_RS18545
uniprot id: U5VY83
names: Similarity
messages: Belongs to the AfsR/DnrI/RedD regulatory family.

1246995:AFR RS12285
gene id: 1246995:AFR_RS12285
uniprot id: U5VUQ9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS37240
gene id: 1246995:AFR_RS37240
uniprot id: U5W957
names: Similarity
messages: Belongs to the TPP enzyme family.

1246995:AFR RS39895
gene id: 1246995:AFR_RS39895
uniprot id: U5WE46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1246995:AFR RS27445
gene id: 1246995:AFR_RS27445
uniprot id: U5W3X7
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1246995:AFR RS08695
gene id: 1246995:AFR_RS08695
uniprot id: U5VW96
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.
messages: Belongs to the aromatic-ring hydroxylase family. TetX subfamily.
messages: Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.
messages: Cytoplasm
messages: Monomer.

1246995:AFR RS18135
gene id: 1246995:AFR_RS18135
uniprot id: U5W1S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS26600
gene id: 1246995:AFR_RS26600
uniprot id: U5W6G4
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS09145
gene id: 1246995:AFR_RS09145
uniprot id: U5VTI5
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS22645
gene id: 1246995:AFR_RS22645
uniprot id: U5W0L2
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

1246995:AFR RS30205
gene id: 1246995:AFR_RS30205
uniprot id: U5W8L4
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

1246995:AFR RS20945
gene id: 1246995:AFR_RS20945
uniprot id: U5W071
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

1246995:AFR RS29400
gene id: 1246995:AFR_RS29400
uniprot id: U5W533
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

1246995:AFR RS07795
gene id: 1246995:AFR_RS07795
uniprot id: U5VSN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1246995:AFR RS04690
gene id: 1246995:AFR_RS04690
uniprot id: U5VUA5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1246995:AFR RS24715
gene id: 1246995:AFR_RS24715
uniprot id: U5W5C2
names: Similarity
messages: Belongs to the DAMOX/DASOX family.

1246995:AFR RS34595
gene id: 1246995:AFR_RS34595
uniprot id: U5W7H9
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.

1246995:AFR RS23870
gene id: 1246995:AFR_RS23870
uniprot id: U5W1W0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS16985
gene id: 1246995:AFR_RS16985
uniprot id: U5VXF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS37100
gene id: 1246995:AFR_RS37100
uniprot id: U5W9E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS06360
gene id: 1246995:AFR_RS06360
uniprot id: U5VVA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

1246995:AFR RS05785
gene id: 1246995:AFR_RS05785
uniprot id: U5VR32
names: Similarity
messages: Belongs to the UPF0434 family.

1246995:AFR RS30805
gene id: 1246995:AFR_RS30805
uniprot id: U5W8X2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1246995:AFR RS13435
gene id: 1246995:AFR_RS13435
uniprot id: U5VVQ1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS30005
gene id: 1246995:AFR_RS30005
uniprot id: U5W5F3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reductive amination of pyruvate to L-alanine.

1246995:AFR RS26535
gene id: 1246995:AFR_RS26535
uniprot id: U5W3G5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.
messages: The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1246995:AFR RS41060
gene id: 1246995:AFR_RS41060
uniprot id: U5WEQ2
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

1246995:AFR RS06065
gene id: 1246995:AFR_RS06065
uniprot id: U5VRP4
names: Similarity
messages: Belongs to the GSP E family.

1246995:AFR RS42415
gene id: 1246995:AFR_RS42415
uniprot id: U5WFJ4
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS11815
gene id: 1246995:AFR_RS11815
uniprot id: U5VV12
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1246995:AFR RS16865
gene id: 1246995:AFR_RS16865
uniprot id: U5VXN9
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS27560
gene id: 1246995:AFR_RS27560
uniprot id: U5W6Z0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS05050
gene id: 1246995:AFR_RS05050
uniprot id: U5VQP9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1246995:AFR RS31030
gene id: 1246995:AFR_RS31030
uniprot id: U5W921
names: Similarity
messages: Belongs to the DSD1 family.

1246995:AFR RS05960
gene id: 1246995:AFR_RS05960
uniprot id: U5VRM1
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase involved in purine salvage.

1246995:AFR RS01520
gene id: 1246995:AFR_RS01520
uniprot id: U5VNS5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

1246995:AFR RS29235
gene id: 1246995:AFR_RS29235
uniprot id: U5W4P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS42705
gene id: 1246995:AFR_RS42705
uniprot id: U5WFD5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1246995:AFR RS41340
gene id: 1246995:AFR_RS41340
uniprot id: U5WEV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

1246995:AFR RS42440
gene id: 1246995:AFR_RS42440
uniprot id: U5WFK0
names: Similarity
messages: Belongs to the UPF0098 family.

1246995:AFR RS22960
gene id: 1246995:AFR_RS22960
uniprot id: U5W4H9
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS21320
gene id: 1246995:AFR_RS21320
uniprot id: U5W0E1
names: Similarity
messages: Belongs to the asparagine synthetase family.

1246995:AFR RS32660
gene id: 1246995:AFR_RS32660
uniprot id: U5W9V5
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS35685
gene id: 1246995:AFR_RS35685
uniprot id: U5W8M1
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

1246995:AFR RS34360
gene id: 1246995:AFR_RS34360
uniprot id: U5WAZ3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.

1246995:AFR RS09395
gene id: 1246995:AFR_RS09395
uniprot id: U5VWR0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1246995:AFR RS30545
gene id: 1246995:AFR_RS30545
uniprot id: U5W5B6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS06820
gene id: 1246995:AFR_RS06820
uniprot id: U5VVA4
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS02345
gene id: 1246995:AFR_RS02345
uniprot id: U5VPK8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1246995:AFR RS16505
gene id: 1246995:AFR_RS16505
uniprot id: U5W102
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS32650
gene id: 1246995:AFR_RS32650
uniprot id: U5W6C8
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS40620
gene id: 1246995:AFR_RS40620
uniprot id: U5WB14
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

1246995:AFR RS43225
gene id: 1246995:AFR_RS43225
uniprot id: U5WCH0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1246995:AFR RS26605
gene id: 1246995:AFR_RS26605
uniprot id: U5W6L5
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS14445
gene id: 1246995:AFR_RS14445
uniprot id: U5VW07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS19105
gene id: 1246995:AFR_RS19105
uniprot id: U5VYY7
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS10305
gene id: 1246995:AFR_RS10305
uniprot id: U5VTY0
names: Similarity
messages: Belongs to the peptidase S8 family.

1246995:AFR RS22320
gene id: 1246995:AFR_RS22320
uniprot id: U5W0F6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS27485
gene id: 1246995:AFR_RS27485
uniprot id: U5W6X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS04830
gene id: 1246995:AFR_RS04830
uniprot id: U5VQX1
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

1246995:AFR RS11795
gene id: 1246995:AFR_RS11795
uniprot id: U5VUJ1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS14600
gene id: 1246995:AFR_RS14600
uniprot id: U5VWE9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1246995:AFR RS06495
gene id: 1246995:AFR_RS06495
uniprot id: U5VRK7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

1246995:AFR RS41375
gene id: 1246995:AFR_RS41375
uniprot id: U5WBA1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS38780
gene id: 1246995:AFR_RS38780
uniprot id: U5WD70
names: Similarity
names: Subunit
messages: Belongs to the sigma-70 factor family. ECF subfamily.
messages: Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.

1246995:AFR RS38055
gene id: 1246995:AFR_RS38055
uniprot id: U5WD09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1246995:AFR RS10070
gene id: 1246995:AFR_RS10070
uniprot id: U5VTZ4
names: Similarity
messages: Belongs to the peptidase C40 family.

1246995:AFR RS07815
gene id: 1246995:AFR_RS07815
uniprot id: U5VW01
names: Similarity
messages: Belongs to the peptidase M1 family.

1246995:AFR RS18150
gene id: 1246995:AFR_RS18150
uniprot id: U5VYB1
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

1246995:AFR RS42315
gene id: 1246995:AFR_RS42315
uniprot id: U5WC19
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS30725
gene id: 1246995:AFR_RS30725
uniprot id: U5W8Q7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

1246995:AFR RS38270
gene id: 1246995:AFR_RS38270
uniprot id: U5WCY1
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

1246995:AFR RS10600
gene id: 1246995:AFR_RS10600
uniprot id: U5VU40
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1246995:AFR RS18670
gene id: 1246995:AFR_RS18670
uniprot id: U5VYB3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1246995:AFR RS31135
gene id: 1246995:AFR_RS31135
uniprot id: U5W616
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS26345
gene id: 1246995:AFR_RS26345
uniprot id: U5W2Z7
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS41675
gene id: 1246995:AFR_RS41675
uniprot id: U5WC63
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

1246995:AFR RS41140
gene id: 1246995:AFR_RS41140
uniprot id: U5WBR6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS30680
gene id: 1246995:AFR_RS30680
uniprot id: U5W8U5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS13585
gene id: 1246995:AFR_RS13585
uniprot id: U5VZ30
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS08850
gene id: 1246995:AFR_RS08850
uniprot id: U5VWN6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1246995:AFR RS41585
gene id: 1246995:AFR_RS41585
uniprot id: U5WBK2
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

1246995:AFR RS10240
gene id: 1246995:AFR_RS10240
uniprot id: U5VXD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1246995:AFR RS36835
gene id: 1246995:AFR_RS36835
uniprot id: U5W8T4
names: Function
names: Similarity
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.

1246995:AFR RS05520
gene id: 1246995:AFR_RS05520
uniprot id: U5VUH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

1246995:AFR RS30370
gene id: 1246995:AFR_RS30370
uniprot id: U5W580
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

1246995:AFR RS13290
gene id: 1246995:AFR_RS13290
uniprot id: U5VYW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS39170
gene id: 1246995:AFR_RS39170
uniprot id: U5WA51
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1246995:AFR RS37645
gene id: 1246995:AFR_RS37645
uniprot id: U5WCL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1246995:AFR RS00010
gene id: 1246995:AFR_RS00010
uniprot id: U5VRK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1246995:AFR RS17900
gene id: 1246995:AFR_RS17900
uniprot id: U5VXV8
names: Similarity
messages: Belongs to the peptidase S66 family.

1246995:AFR RS17540
gene id: 1246995:AFR_RS17540
uniprot id: U5VXZ6
names: Similarity
messages: Belongs to the peptidase S8 family.

1246995:AFR RS36505
gene id: 1246995:AFR_RS36505
uniprot id: U5W933
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1246995:AFR RS23705
gene id: 1246995:AFR_RS23705
uniprot id: U5W4Q5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.
messages: Belongs to the aromatic-ring hydroxylase family. TetX subfamily.
messages: Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.
messages: Cytoplasm
messages: Monomer.

1246995:AFR RS33130
gene id: 1246995:AFR_RS33130
uniprot id: U5W6L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

1246995:AFR RS26545
gene id: 1246995:AFR_RS26545
uniprot id: U5W367
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic ubiquitin-like protein family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
messages: Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.
messages: The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.

1246995:AFR RS15060
gene id: 1246995:AFR_RS15060
uniprot id: U5VWW0
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.
messages: Binds 1 zinc ion per subunit.

1246995:AFR RS08180
gene id: 1246995:AFR_RS08180
uniprot id: U5VW02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS31200
gene id: 1246995:AFR_RS31200
uniprot id: U5W8Z7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1246995:AFR RS39600
gene id: 1246995:AFR_RS39600
uniprot id: U5WAW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS29775
gene id: 1246995:AFR_RS29775
uniprot id: U5W890
names: Similarity
messages: Belongs to the aminoglycoside phosphotransferase family.

1246995:AFR RS31220
gene id: 1246995:AFR_RS31220
uniprot id: U5W5Q8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1246995:AFR RS35430
gene id: 1246995:AFR_RS35430
uniprot id: U5WBI1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

1246995:AFR RS33325
gene id: 1246995:AFR_RS33325
uniprot id: U5W6X1
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

1246995:AFR RS31080
gene id: 1246995:AFR_RS31080
uniprot id: U5W932
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1246995:AFR RS31020
gene id: 1246995:AFR_RS31020
uniprot id: U5W5L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS30280
gene id: 1246995:AFR_RS30280
uniprot id: U5W8M5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1246995:AFR RS05310
gene id: 1246995:AFR_RS05310
uniprot id: U5VUD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

1246995:AFR RS34235
gene id: 1246995:AFR_RS34235
uniprot id: U5WAW9
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.

1246995:AFR RS43895
gene id: 1246995:AFR_RS43895
uniprot id: U5W2N4
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.

1246995:AFR RS10250
gene id: 1246995:AFR_RS10250
uniprot id: U5VTJ5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS39980
gene id: 1246995:AFR_RS39980
uniprot id: U5WB45
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

1246995:AFR RS36170
gene id: 1246995:AFR_RS36170
uniprot id: U5W8I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1246995:AFR RS36700
gene id: 1246995:AFR_RS36700
uniprot id: U5WCB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1246995:AFR RS39180
gene id: 1246995:AFR_RS39180
uniprot id: U5WDI9
names: Function
messages: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.

1246995:AFR RS23890
gene id: 1246995:AFR_RS23890
uniprot id: U5W1W5
names: Similarity
messages: Belongs to the 4-hydroxy-2-oxovalerate aldolase family.

1246995:AFR RS36380
gene id: 1246995:AFR_RS36380
uniprot id: U5W904
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1246995:AFR RS39645
gene id: 1246995:AFR_RS39645
uniprot id: U5WE00
names: Subunit
messages: Heterodimer of an alpha and a beta chain.

1246995:AFR RS27075
gene id: 1246995:AFR_RS27075
uniprot id: U5W6P6
names: Similarity
messages: Belongs to the AHA1 family.

1246995:AFR RS13840
gene id: 1246995:AFR_RS13840
uniprot id: U5VZE4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

1246995:AFR RS27070
gene id: 1246995:AFR_RS27070
uniprot id: U5W3F5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS10130
gene id: 1246995:AFR_RS10130
uniprot id: U5VTU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1246995:AFR RS15840
gene id: 1246995:AFR_RS15840
uniprot id: U5VWQ1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1246995:AFR RS40995
gene id: 1246995:AFR_RS40995
uniprot id: U5WB20
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS04945
gene id: 1246995:AFR_RS04945
uniprot id: U5VR30
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS37310
gene id: 1246995:AFR_RS37310
uniprot id: U5W912
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

1246995:AFR RS29575
gene id: 1246995:AFR_RS29575
uniprot id: U5W563
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

1246995:AFR RS38550
gene id: 1246995:AFR_RS38550
uniprot id: U5WD27
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1246995:AFR RS42190
gene id: 1246995:AFR_RS42190
uniprot id: U5WC01
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

1246995:AFR RS15895
gene id: 1246995:AFR_RS15895
uniprot id: U5VX44
names: Similarity
messages: Belongs to the arginase family.

1246995:AFR RS22295
gene id: 1246995:AFR_RS22295
uniprot id: U5W0F4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS30830
gene id: 1246995:AFR_RS30830
uniprot id: U5W8X8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

1246995:AFR RS35080
gene id: 1246995:AFR_RS35080
uniprot id: U5WBC0
names: Similarity
messages: Belongs to the AHA1 family.

1246995:AFR RS29140
gene id: 1246995:AFR_RS29140
uniprot id: U5W7X6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS01365
gene id: 1246995:AFR_RS01365
uniprot id: U5VP33
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1246995:AFR RS33855
gene id: 1246995:AFR_RS33855
uniprot id: U5W781
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

1246995:AFR RS08065
gene id: 1246995:AFR_RS08065
uniprot id: U5VW46
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1246995:AFR RS06780
gene id: 1246995:AFR_RS06780
uniprot id: U5VS53
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS05680
gene id: 1246995:AFR_RS05680
uniprot id: U5VRG7
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1246995:AFR RS21405
gene id: 1246995:AFR_RS21405
uniprot id: U5W057
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1246995:AFR RS25315
gene id: 1246995:AFR_RS25315
uniprot id: U5W5N5
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

1246995:AFR RS01720
gene id: 1246995:AFR_RS01720
uniprot id: U5VNV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1246995:AFR RS16920
gene id: 1246995:AFR_RS16920
uniprot id: U5W105
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.

1246995:AFR RS13400
gene id: 1246995:AFR_RS13400
uniprot id: U5VVW2
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS10685
gene id: 1246995:AFR_RS10685
uniprot id: U5VXL3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Bind 1 Zn(2+) per subunit.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.

1246995:AFR RS03690
gene id: 1246995:AFR_RS03690
uniprot id: U5VPY7
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1246995:AFR RS36870
gene id: 1246995:AFR_RS36870
uniprot id: U5WC78
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1246995:AFR RS01745
gene id: 1246995:AFR_RS01745
uniprot id: U5VNW4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1246995:AFR RS11175
gene id: 1246995:AFR_RS11175
uniprot id: U5VU30
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1246995:AFR RS04710
gene id: 1246995:AFR_RS04710
uniprot id: U5VU32
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1246995:AFR RS24965
gene id: 1246995:AFR_RS24965
uniprot id: U5W5H0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

1246995:AFR RS24215
gene id: 1246995:AFR_RS24215
uniprot id: U5W255
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

1246995:AFR RS01175
gene id: 1246995:AFR_RS01175
uniprot id: U5VNZ8
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS43900
gene id: 1246995:AFR_RS43900
uniprot id: U5W5M1
names: Similarity
messages: Belongs to the DyP-type peroxidase family.

1246995:AFR RS10060
gene id: 1246995:AFR_RS10060
uniprot id: U5VX32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

1246995:AFR RS08450
gene id: 1246995:AFR_RS08450
uniprot id: U5VWC2
names: Similarity
messages: Belongs to the peptidase S8 family.

1246995:AFR RS36520
gene id: 1246995:AFR_RS36520
uniprot id: U5WC04
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1246995:AFR RS42725
gene id: 1246995:AFR_RS42725
uniprot id: U5WC74
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

1246995:AFR RS23595
gene id: 1246995:AFR_RS23595
uniprot id: U5W123
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS01085
gene id: 1246995:AFR_RS01085
uniprot id: U5VS51
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS04715
gene id: 1246995:AFR_RS04715
uniprot id: U5VUA9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1246995:AFR RS36690
gene id: 1246995:AFR_RS36690
uniprot id: U5W8W4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

1246995:AFR RS41600
gene id: 1246995:AFR_RS41600
uniprot id: U5WC15
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1246995:AFR RS17065
gene id: 1246995:AFR_RS17065
uniprot id: U5VXS1
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1246995:AFR RS00735
gene id: 1246995:AFR_RS00735
uniprot id: U5VN83
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1246995:AFR RS38695
gene id: 1246995:AFR_RS38695
uniprot id: U5W9S1
names: Similarity
messages: Belongs to the LOG family.

1246995:AFR RS26525
gene id: 1246995:AFR_RS26525
uniprot id: U5W6F2
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
messages: Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
messages: The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.

1246995:AFR RS37075
gene id: 1246995:AFR_RS37075
uniprot id: U5W9D9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1246995:AFR RS20750
gene id: 1246995:AFR_RS20750
uniprot id: U5VZG0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS22155
gene id: 1246995:AFR_RS22155
uniprot id: U5W0M7
names: Similarity
messages: Belongs to the manganese catalase family.

1246995:AFR RS04990
gene id: 1246995:AFR_RS04990
uniprot id: U5VUG2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1246995:AFR RS06890
gene id: 1246995:AFR_RS06890
uniprot id: U5VRR6
names: Similarity
messages: Belongs to the GSP E family.

1246995:AFR RS03460
gene id: 1246995:AFR_RS03460
uniprot id: U5VQ79
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

1246995:AFR RS07935
gene id: 1246995:AFR_RS07935
uniprot id: U5VVV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1246995:AFR RS06750
gene id: 1246995:AFR_RS06750
uniprot id: U5VVH2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1246995:AFR RS22805
gene id: 1246995:AFR_RS22805
uniprot id: U5W492
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

1246995:AFR RS43150
gene id: 1246995:AFR_RS43150
uniprot id: U5WC87
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS20065
gene id: 1246995:AFR_RS20065
uniprot id: U5W2V6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS10215
gene id: 1246995:AFR_RS10215
uniprot id: U5VX55
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1246995:AFR RS15880
gene id: 1246995:AFR_RS15880
uniprot id: U5W0I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

1246995:AFR RS16120
gene id: 1246995:AFR_RS16120
uniprot id: U5VX85
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

1246995:AFR RS36015
gene id: 1246995:AFR_RS36015
uniprot id: U5W883
names: Similarity
messages: Belongs to the peptidase S1 family.

1246995:AFR RS27225
gene id: 1246995:AFR_RS27225
uniprot id: U5W6X8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. TreS subfamily.

1246995:AFR RS08535
gene id: 1246995:AFR_RS08535
uniprot id: U5VSL0
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

1246995:AFR RS04210
gene id: 1246995:AFR_RS04210
uniprot id: U5VQC0
names: Function
names: Similarity
messages: Belongs to the UPF0677 family.
messages: Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.

1246995:AFR RS27090
gene id: 1246995:AFR_RS27090
uniprot id: U5W368
names: Similarity
messages: Belongs to the citrate synthase family.

1246995:AFR RS08000
gene id: 1246995:AFR_RS08000
uniprot id: U5VS98
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1246995:AFR RS14450
gene id: 1246995:AFR_RS14450
uniprot id: U5VWC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS13350
gene id: 1246995:AFR_RS13350
uniprot id: U5VVV0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS06105
gene id: 1246995:AFR_RS06105
uniprot id: U5VUT1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS35585
gene id: 1246995:AFR_RS35585
uniprot id: U5W8K5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1246995:AFR RS13205
gene id: 1246995:AFR_RS13205
uniprot id: U5VV74
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS07235
gene id: 1246995:AFR_RS07235
uniprot id: U5VS87
names: Similarity
messages: Belongs to the AfsR/DnrI/RedD regulatory family.

1246995:AFR RS25870
gene id: 1246995:AFR_RS25870
uniprot id: U5W2E5
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS31865
gene id: 1246995:AFR_RS31865
uniprot id: U5W9F6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS01750
gene id: 1246995:AFR_RS01750
uniprot id: U5VPB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1246995:AFR RS00730
gene id: 1246995:AFR_RS00730
uniprot id: U5VNQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1246995:AFR RS04520
gene id: 1246995:AFR_RS04520
uniprot id: U5VQU8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1246995:AFR RS27670
gene id: 1246995:AFR_RS27670
uniprot id: U5W423
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

1246995:AFR RS05755
gene id: 1246995:AFR_RS05755
uniprot id: U5VRI0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1246995:AFR RS11505
gene id: 1246995:AFR_RS11505
uniprot id: U5VXZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS05790
gene id: 1246995:AFR_RS05790
uniprot id: U5VRE8
names: Similarity
messages: Belongs to the PGI/PMI family.

1246995:AFR RS21240
gene id: 1246995:AFR_RS21240
uniprot id: U5W3H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sbp family.
messages: Cell membrane

1246995:AFR RS15260
gene id: 1246995:AFR_RS15260
uniprot id: U5VX00
names: Similarity
messages: Belongs to the UPF0098 family.

1246995:AFR RS16555
gene id: 1246995:AFR_RS16555
uniprot id: U5W109
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1246995:AFR RS05850
gene id: 1246995:AFR_RS05850
uniprot id: U5VUW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

1246995:AFR RS34070
gene id: 1246995:AFR_RS34070
uniprot id: U5W7S6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1246995:AFR RS40625
gene id: 1246995:AFR_RS40625
uniprot id: U5WE83
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

1246995:AFR RS19625
gene id: 1246995:AFR_RS19625
uniprot id: U5VZG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

1246995:AFR RS05815
gene id: 1246995:AFR_RS05815
uniprot id: U5VRF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

1246995:AFR RS42830
gene id: 1246995:AFR_RS42830
uniprot id: U5WFG1
names: Similarity
names: Subunit
messages: Belongs to the Bpa family.
messages: Forms a homooligomeric, either hexameric or heptameric, ring-like structure which stacks co-axially with the proteasomal alpha-rings.

1246995:AFR RS10260
gene id: 1246995:AFR_RS10260
uniprot id: U5VX67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1246995:AFR RS01770
gene id: 1246995:AFR_RS01770
uniprot id: U5VNW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1246995:AFR RS09230
gene id: 1246995:AFR_RS09230
uniprot id: U5VTJ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

1246995:AFR RS04290
gene id: 1246995:AFR_RS04290
uniprot id: U5VQN6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1246995:AFR RS37635
gene id: 1246995:AFR_RS37635
uniprot id: U5W966
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the NOS family. Bacterial NOS oxygenase subfamily.
messages: Catalyzes the production of nitric oxide.
messages: Homodimer.
messages: This protein is similar to the oxygenase domain of eukaryotic nitric oxide synthases but lacks the reductase domain which, in eukaryotes, is responsible for transfer of electrons to the ferric heme during nitric oxide synthesis.

1246995:AFR RS05010
gene id: 1246995:AFR_RS05010
uniprot id: U5VU86
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

1246995:AFR RS34155
gene id: 1246995:AFR_RS34155
uniprot id: U5W7H3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1246995:AFR RS04540
gene id: 1246995:AFR_RS04540
uniprot id: U5VU81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1246995:AFR RS05580
gene id: 1246995:AFR_RS05580
uniprot id: U5VRF1
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

1246995:AFR RS30705
gene id: 1246995:AFR_RS30705
uniprot id: U5W8U9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1246995:AFR RS21935
gene id: 1246995:AFR_RS21935
uniprot id: U5W3S0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS05475
gene id: 1246995:AFR_RS05475
uniprot id: U5VUP6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1246995:AFR RS03425
gene id: 1246995:AFR_RS03425
uniprot id: U5VTA3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1246995:AFR RS10715
gene id: 1246995:AFR_RS10715
uniprot id: U5VUB5
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

1246995:AFR RS22165
gene id: 1246995:AFR_RS22165
uniprot id: U5W434
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1246995:AFR RS09315
gene id: 1246995:AFR_RS09315
uniprot id: U5VTF8
names: Similarity
messages: Belongs to the YciI family.

1246995:AFR RS06965
gene id: 1246995:AFR_RS06965
uniprot id: U5VS40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS10780
gene id: 1246995:AFR_RS10780
uniprot id: U5VXG4
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1246995:AFR RS11500
gene id: 1246995:AFR_RS11500
uniprot id: U5VUQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS10625
gene id: 1246995:AFR_RS10625
uniprot id: U5VU45
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1246995:AFR RS38825
gene id: 1246995:AFR_RS38825
uniprot id: U5WA11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. EgtD family.
messages: Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine.
messages: Monomer.

1246995:AFR RS14145
gene id: 1246995:AFR_RS14145
uniprot id: U5VZM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CopC family.
messages: Periplasm

1246995:AFR RS22400
gene id: 1246995:AFR_RS22400
uniprot id: U5W0R4
names: Similarity
messages: Belongs to the ketopantoate reductase family.

1246995:AFR RS04575
gene id: 1246995:AFR_RS04575
uniprot id: U5VQH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1246995:AFR RS17770
gene id: 1246995:AFR_RS17770
uniprot id: U5VY38
names: Similarity
messages: Belongs to the glycosyl hydrolase 42 family.

1246995:AFR RS30290
gene id: 1246995:AFR_RS30290
uniprot id: U5W4Z4
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS22490
gene id: 1246995:AFR_RS22490
uniprot id: U5W147
names: Function
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).

1246995:AFR RS35795
gene id: 1246995:AFR_RS35795
uniprot id: U5W8A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS05270
gene id: 1246995:AFR_RS05270
uniprot id: U5VR94
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.

1246995:AFR RS01450
gene id: 1246995:AFR_RS01450
uniprot id: U5VP58
names: Similarity
messages: Belongs to the UbiD family.

1246995:AFR RS18775
gene id: 1246995:AFR_RS18775
uniprot id: U5VYN5
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1246995:AFR RS42010
gene id: 1246995:AFR_RS42010
uniprot id: U5WBX2
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1246995:AFR RS06245
gene id: 1246995:AFR_RS06245
uniprot id: U5VRC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS12650
gene id: 1246995:AFR_RS12650
uniprot id: U5VVG3
names: Similarity
messages: Belongs to the peptidase S1 family.

1246995:AFR RS33275
gene id: 1246995:AFR_RS33275
uniprot id: U5W6W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS26760
gene id: 1246995:AFR_RS26760
uniprot id: U5W316
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
messages: Monomer.

1246995:AFR RS19825
gene id: 1246995:AFR_RS19825
uniprot id: U5VZ05
names: Similarity
messages: Belongs to the YciI family.

1246995:AFR RS04765
gene id: 1246995:AFR_RS04765
uniprot id: U5VUB8
names: Function
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

1246995:AFR RS05915
gene id: 1246995:AFR_RS05915
uniprot id: U5VR57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

1246995:AFR RS14085
gene id: 1246995:AFR_RS14085
uniprot id: U5VW71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS39690
gene id: 1246995:AFR_RS39690
uniprot id: U5WDQ7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1246995:AFR RS00400
gene id: 1246995:AFR_RS00400
uniprot id: U5VRS6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS12910
gene id: 1246995:AFR_RS12910
uniprot id: U5VVE9
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS44210
gene id: 1246995:AFR_RS44210
uniprot id: U5W755
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1246995:AFR RS17240
gene id: 1246995:AFR_RS17240
uniprot id: U5VXU7
names: Similarity
messages: Belongs to the glycosyl hydrolase 27 family.

1246995:AFR RS01825
gene id: 1246995:AFR_RS01825
uniprot id: U5VPC3
names: Similarity
messages: Belongs to the WXG100 family.

1246995:AFR RS14815
gene id: 1246995:AFR_RS14815
uniprot id: U5VWQ7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS10520
gene id: 1246995:AFR_RS10520
uniprot id: U5VTP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS31450
gene id: 1246995:AFR_RS31450
uniprot id: U5W693
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS36755
gene id: 1246995:AFR_RS36755
uniprot id: U5W991
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.

1246995:AFR RS34275
gene id: 1246995:AFR_RS34275
uniprot id: U5W7J1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS11230
gene id: 1246995:AFR_RS11230
uniprot id: U5VUG4
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1246995:AFR RS21390
gene id: 1246995:AFR_RS21390
uniprot id: U5W3J8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS01755
gene id: 1246995:AFR_RS01755
uniprot id: U5VSE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1246995:AFR RS36710
gene id: 1246995:AFR_RS36710
uniprot id: U5W8R5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1246995:AFR RS00020
gene id: 1246995:AFR_RS00020
uniprot id: U5VMU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1246995:AFR RS30750
gene id: 1246995:AFR_RS30750
uniprot id: U5W8R1
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

1246995:AFR RS22060
gene id: 1246995:AFR_RS22060
uniprot id: U5W3U5
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS18010
gene id: 1246995:AFR_RS18010
uniprot id: U5W1J6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS40595
gene id: 1246995:AFR_RS40595
uniprot id: U5WB08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

1246995:AFR RS13005
gene id: 1246995:AFR_RS13005
uniprot id: U5VV37
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1246995:AFR RS43165
gene id: 1246995:AFR_RS43165
uniprot id: U5WFW8
names: Similarity
messages: Belongs to the thioredoxin family.

1246995:AFR RS28260
gene id: 1246995:AFR_RS28260
uniprot id: U5W3U1
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

1246995:AFR RS22250
gene id: 1246995:AFR_RS22250
uniprot id: U5W0P0
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS09365
gene id: 1246995:AFR_RS09365
uniprot id: U5VTG6
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

1246995:AFR RS40890
gene id: 1246995:AFR_RS40890
uniprot id: U5WBM0
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

1246995:AFR RS39580
gene id: 1246995:AFR_RS39580
uniprot id: U5WAB9
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS00005
gene id: 1246995:AFR_RS00005
uniprot id: U5VRE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1246995:AFR RS26175
gene id: 1246995:AFR_RS26175
uniprot id: U5W2W1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS09150
gene id: 1246995:AFR_RS09150
uniprot id: U5VT16
names: Similarity
messages: Belongs to the glutamine synthetase family.

1246995:AFR RS21650
gene id: 1246995:AFR_RS21650
uniprot id: U5W0Q3
names: Similarity
messages: Belongs to the OsmC/Ohr family.

1246995:AFR RS41775
gene id: 1246995:AFR_RS41775
uniprot id: U5WC80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1246995:AFR RS11290
gene id: 1246995:AFR_RS11290
uniprot id: U5VUM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS37555
gene id: 1246995:AFR_RS37555
uniprot id: U5W9M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1246995:AFR RS20605
gene id: 1246995:AFR_RS20605
uniprot id: U5VZP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

1246995:AFR RS14005
gene id: 1246995:AFR_RS14005
uniprot id: U5VVT3
names: Similarity
messages: Belongs to the fructosamine kinase family.

1246995:AFR RS42045
gene id: 1246995:AFR_RS42045
uniprot id: U5WF21
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS24195
gene id: 1246995:AFR_RS24195
uniprot id: U5W1K4
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS09975
gene id: 1246995:AFR_RS09975
uniprot id: U5VTX4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS10530
gene id: 1246995:AFR_RS10530
uniprot id: U5VXB9
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

1246995:AFR RS01020
gene id: 1246995:AFR_RS01020
uniprot id: U5VNW3
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS30560
gene id: 1246995:AFR_RS30560
uniprot id: U5W5R0
names: Subcellular Location Annotation
messages: Secreted

1246995:AFR RS02735
gene id: 1246995:AFR_RS02735
uniprot id: U5VT50
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1246995:AFR RS30625
gene id: 1246995:AFR_RS30625
uniprot id: U5W8N9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1246995:AFR RS05635
gene id: 1246995:AFR_RS05635
uniprot id: U5VR02
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1246995:AFR RS03400
gene id: 1246995:AFR_RS03400
uniprot id: U5VT99
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS09470
gene id: 1246995:AFR_RS09470
uniprot id: U5VTI1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 3 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1246995:AFR RS08270
gene id: 1246995:AFR_RS08270
uniprot id: U5VSE8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1246995:AFR RS22940
gene id: 1246995:AFR_RS22940
uniprot id: U5W1D4
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.

1246995:AFR RS29745
gene id: 1246995:AFR_RS29745
uniprot id: U5W886
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1246995:AFR RS07015
gene id: 1246995:AFR_RS07015
uniprot id: U5VS49
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

1246995:AFR RS33065
gene id: 1246995:AFR_RS33065
uniprot id: U5WA31
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

1246995:AFR RS00345
gene id: 1246995:AFR_RS00345
uniprot id: U5VRR8
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS40900
gene id: 1246995:AFR_RS40900
uniprot id: U5WB70
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: Belongs to the nitrobindin family.
messages: Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.
messages: Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.
messages: Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS15015
gene id: 1246995:AFR_RS15015
uniprot id: U5VW94
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS06710
gene id: 1246995:AFR_RS06710
uniprot id: U5VRP0
names: Similarity
messages: Belongs to the AfsR/DnrI/RedD regulatory family.

1246995:AFR RS09105
gene id: 1246995:AFR_RS09105
uniprot id: U5VWT1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS30735
gene id: 1246995:AFR_RS30735
uniprot id: U5W5U0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1246995:AFR RS04535
gene id: 1246995:AFR_RS04535
uniprot id: U5VTZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1246995:AFR RS34135
gene id: 1246995:AFR_RS34135
uniprot id: U5WAR7
names: Similarity
messages: Belongs to the CobH/CbiC family.

1246995:AFR RS13650
gene id: 1246995:AFR_RS13650
uniprot id: U5VVG7
names: Similarity
messages: Belongs to the CdaR family.

1246995:AFR RS04635
gene id: 1246995:AFR_RS04635
uniprot id: U5VU17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1246995:AFR RS05795
gene id: 1246995:AFR_RS05795
uniprot id: U5VUM8
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS32270
gene id: 1246995:AFR_RS32270
uniprot id: U5W6C2
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS31480
gene id: 1246995:AFR_RS31480
uniprot id: U5W5Q1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS09535
gene id: 1246995:AFR_RS09535
uniprot id: U5VT75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS20120
gene id: 1246995:AFR_RS20120
uniprot id: U5VZR7
names: Subcellular Location Annotation
messages: Cytoplasm

1246995:AFR RS30780
gene id: 1246995:AFR_RS30780
uniprot id: U5W8W6
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1246995:AFR RS07265
gene id: 1246995:AFR_RS07265
uniprot id: U5VVJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS39750
gene id: 1246995:AFR_RS39750
uniprot id: U5WAZ5
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

1246995:AFR RS27045
gene id: 1246995:AFR_RS27045
uniprot id: U5W3F3
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and hydrogenobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of hydrogenobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CobB catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

1246995:AFR RS37935
gene id: 1246995:AFR_RS37935
uniprot id: U5W9V4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS20670
gene id: 1246995:AFR_RS20670
uniprot id: U5W016
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1246995:AFR RS20170
gene id: 1246995:AFR_RS20170
uniprot id: U5VZS5
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS33395
gene id: 1246995:AFR_RS33395
uniprot id: U5W7C1
names: Subcellular Location Annotation
messages: Cytoplasm

1246995:AFR RS05005
gene id: 1246995:AFR_RS05005
uniprot id: U5VR04
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1246995:AFR RS42630
gene id: 1246995:AFR_RS42630
uniprot id: U5WFC0
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1246995:AFR RS07625
gene id: 1246995:AFR_RS07625
uniprot id: U5VVX0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1246995:AFR RS01885
gene id: 1246995:AFR_RS01885
uniprot id: U5VSQ0
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1246995:AFR RS04230
gene id: 1246995:AFR_RS04230
uniprot id: U5VQQ6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS36610
gene id: 1246995:AFR_RS36610
uniprot id: U5W8P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1246995:AFR RS19455
gene id: 1246995:AFR_RS19455
uniprot id: U5VYU3
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

1246995:AFR RS20685
gene id: 1246995:AFR_RS20685
uniprot id: U5W305
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS17455
gene id: 1246995:AFR_RS17455
uniprot id: U5VY86
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS41950
gene id: 1246995:AFR_RS41950
uniprot id: U5WCA9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS09345
gene id: 1246995:AFR_RS09345
uniprot id: U5VWQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Cytoplasm
messages: Homodimer.

1246995:AFR RS08865
gene id: 1246995:AFR_RS08865
uniprot id: U5VT86
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS34550
gene id: 1246995:AFR_RS34550
uniprot id: U5W7N8
names: Function
messages: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.

1246995:AFR RS09760
gene id: 1246995:AFR_RS09760
uniprot id: U5VTN0
names: Cofactor
names: Similarity
messages: Belongs to the class-II DAHP synthase family.
messages: Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.

1246995:AFR RS03820
gene id: 1246995:AFR_RS03820
uniprot id: U5VTM8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS01390
gene id: 1246995:AFR_RS01390
uniprot id: U5VP38
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS30285
gene id: 1246995:AFR_RS30285
uniprot id: U5W5K3
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS16470
gene id: 1246995:AFR_RS16470
uniprot id: U5VXI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.
messages: Cytoplasm

1246995:AFR RS43070
gene id: 1246995:AFR_RS43070
uniprot id: U5WCW8
names: Similarity
messages: Belongs to the AP endonuclease 2 family.

1246995:AFR RS19360
gene id: 1246995:AFR_RS19360
uniprot id: U5VXL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

1246995:AFR RS09820
gene id: 1246995:AFR_RS09820
uniprot id: U5VX50
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS09180
gene id: 1246995:AFR_RS09180
uniprot id: U5VTD5
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS32580
gene id: 1246995:AFR_RS32580
uniprot id: U5W6G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1246995:AFR RS21990
gene id: 1246995:AFR_RS21990
uniprot id: U5W400
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

1246995:AFR RS32870
gene id: 1246995:AFR_RS32870
uniprot id: U5WA40
names: Similarity
messages: Belongs to the cytochrome P450 family.

1246995:AFR RS31640
gene id: 1246995:AFR_RS31640
uniprot id: U5W9B8
names: Similarity
messages: Belongs to the allantoicase family.

1246995:AFR RS41460
gene id: 1246995:AFR_RS41460
uniprot id: U5WBH9
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

1246995:AFR RS10635
gene id: 1246995:AFR_RS10635
uniprot id: U5VXK3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1246995:AFR RS44135
gene id: 1246995:AFR_RS44135
uniprot id: U5W5L3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS40965
gene id: 1246995:AFR_RS40965
uniprot id: U5WBN4
names: Similarity
messages: Belongs to the PstS family.

1246995:AFR RS41315
gene id: 1246995:AFR_RS41315
uniprot id: U5WEV2
names: Similarity
messages: Belongs to the peptidase S8 family.

1246995:AFR RS09795
gene id: 1246995:AFR_RS09795
uniprot id: U5VX46
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

1246995:AFR RS16110
gene id: 1246995:AFR_RS16110
uniprot id: U5VXG5
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.

1246995:AFR RS04905
gene id: 1246995:AFR_RS04905
uniprot id: U5VQY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1246995:AFR RS26090
gene id: 1246995:AFR_RS26090
uniprot id: U5W357
names: Similarity
messages: Belongs to the AAA ATPase family.

1246995:AFR RS36860
gene id: 1246995:AFR_RS36860
uniprot id: U5W8T7
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1246995:AFR RS38255
gene id: 1246995:AFR_RS38255
uniprot id: U5WD42
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1246995:AFR RS18205
gene id: 1246995:AFR_RS18205
uniprot id: U5W1N2
names: Similarity
messages: Belongs to the PstS family.

1246995:AFR RS01865
gene id: 1246995:AFR_RS01865
uniprot id: U5VPC0
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS20870
gene id: 1246995:AFR_RS20870
uniprot id: U5W055
names: Similarity
messages: Belongs to the TPP enzyme family.

1246995:AFR RS38265
gene id: 1246995:AFR_RS38265
uniprot id: U5W9H8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

1246995:AFR RS22560
gene id: 1246995:AFR_RS22560
uniprot id: U5W4A7
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS34345
gene id: 1246995:AFR_RS34345
uniprot id: U5W7E0
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

1246995:AFR RS47785
gene id: 1246995:AFR_RS47785
uniprot id: U5VV25
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1246995:AFR RS23220
gene id: 1246995:AFR_RS23220
uniprot id: U5W1I1
names: Similarity
messages: Belongs to the peptidase S33 family.

1246995:AFR RS27915
gene id: 1246995:AFR_RS27915
uniprot id: U5W796
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1246995:AFR RS22590
gene id: 1246995:AFR_RS22590
uniprot id: U5W169
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS42950
gene id: 1246995:AFR_RS42950
uniprot id: U5WCB5
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1246995:AFR RS32405
gene id: 1246995:AFR_RS32405
uniprot id: U5W9Q6
names: Similarity
messages: Belongs to the F420H(2)-dependent quinone reductase family.

1246995:AFR RS10225
gene id: 1246995:AFR_RS10225
uniprot id: U5VU25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1246995:AFR RS00755
gene id: 1246995:AFR_RS00755
uniprot id: U5VNQ9
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

1246995:AFR RS11190
gene id: 1246995:AFR_RS11190
uniprot id: U5VXV7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS01625
gene id: 1246995:AFR_RS01625
uniprot id: U5VP91
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

1246995:AFR RS01705
gene id: 1246995:AFR_RS01705
uniprot id: U5VSD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1246995:AFR RS16715
gene id: 1246995:AFR_RS16715
uniprot id: U5W139
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1246995:AFR RS01120
gene id: 1246995:AFR_RS01120
uniprot id: U5VNF7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS22970
gene id: 1246995:AFR_RS22970
uniprot id: U5W0R0
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-69 and Arg-72) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

1246995:AFR RS36080
gene id: 1246995:AFR_RS36080
uniprot id: U5WBV1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS20330
gene id: 1246995:AFR_RS20330
uniprot id: U5VZI6
names: Similarity
messages: Belongs to the peptidase C40 family.

1246995:AFR RS29450
gene id: 1246995:AFR_RS29450
uniprot id: U5W542
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS09495
gene id: 1246995:AFR_RS09495
uniprot id: U5VWS8
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

1246995:AFR RS14560
gene id: 1246995:AFR_RS14560
uniprot id: U5VZV0
names: Similarity
names: Subunit
messages: Belongs to the sigma-70 factor family. ECF subfamily.
messages: Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.

1246995:AFR RS11295
gene id: 1246995:AFR_RS11295
uniprot id: U5VU58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS30595
gene id: 1246995:AFR_RS30595
uniprot id: U5W5C5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1246995:AFR RS26820
gene id: 1246995:AFR_RS26820
uniprot id: U5W6K1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS02035
gene id: 1246995:AFR_RS02035
uniprot id: U5VSJ7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1246995:AFR RS41400
gene id: 1246995:AFR_RS41400
uniprot id: U5WBA7
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1246995:AFR RS46080
gene id: 1246995:AFR_RS46080
uniprot id: U5VWE1
names: Similarity
messages: Belongs to the ros/MucR family.

1246995:AFR RS27900
gene id: 1246995:AFR_RS27900
uniprot id: U5W3M1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1246995:AFR RS33920
gene id: 1246995:AFR_RS33920
uniprot id: U5W7M7
names: Similarity
messages: Belongs to the CFA/CMAS family.

1246995:AFR RS28885
gene id: 1246995:AFR_RS28885
uniprot id: U5W472
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

1246995:AFR RS00040
gene id: 1246995:AFR_RS00040
uniprot id: U5VNB8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1246995:AFR RS09060
gene id: 1246995:AFR_RS09060
uniprot id: U5VTH6
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1246995:AFR RS37610
gene id: 1246995:AFR_RS37610
uniprot id: U5W962
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1246995:AFR RS43660
gene id: 1246995:AFR_RS43660
uniprot id: U5W0G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS21395
gene id: 1246995:AFR_RS21395
uniprot id: U5W0F8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1246995:AFR RS30980
gene id: 1246995:AFR_RS30980
uniprot id: U5W910
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS02135
gene id: 1246995:AFR_RS02135
uniprot id: U5VSL4
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

1246995:AFR RS06325
gene id: 1246995:AFR_RS06325
uniprot id: U5VRS1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1246995:AFR RS21230
gene id: 1246995:AFR_RS21230
uniprot id: U5W020
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1246995:AFR RS21440
gene id: 1246995:AFR_RS21440
uniprot id: U5W3K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS15385
gene id: 1246995:AFR_RS15385
uniprot id: U5VX25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS35850
gene id: 1246995:AFR_RS35850
uniprot id: U5WBL6
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

1246995:AFR RS05120
gene id: 1246995:AFR_RS05120
uniprot id: U5VR64
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1246995:AFR RS36325
gene id: 1246995:AFR_RS36325
uniprot id: U5WBV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1246995:AFR RS04865
gene id: 1246995:AFR_RS04865
uniprot id: U5VUD7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1246995:AFR RS15770
gene id: 1246995:AFR_RS15770
uniprot id: U5VX22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS18650
gene id: 1246995:AFR_RS18650
uniprot id: U5VYK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS32525
gene id: 1246995:AFR_RS32525
uniprot id: U5W6B2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS04305
gene id: 1246995:AFR_RS04305
uniprot id: U5VQR8
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS39410
gene id: 1246995:AFR_RS39410
uniprot id: U5WAS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1246995:AFR RS21480
gene id: 1246995:AFR_RS21480
uniprot id: U5W075
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1246995:AFR RS39815
gene id: 1246995:AFR_RS39815
uniprot id: U5WDT0
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1246995:AFR RS26975
gene id: 1246995:AFR_RS26975
uniprot id: U5W6M8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1246995:AFR RS17955
gene id: 1246995:AFR_RS17955
uniprot id: U5VY70
names: Similarity
messages: Belongs to the FAD-binding monooxygenase family.

1246995:AFR RS22715
gene id: 1246995:AFR_RS22715
uniprot id: U5W192
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

1246995:AFR RS19910
gene id: 1246995:AFR_RS19910
uniprot id: U5W2L4
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

1246995:AFR RS02250
gene id: 1246995:AFR_RS02250
uniprot id: U5VP39
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

1246995:AFR RS27460
gene id: 1246995:AFR_RS27460
uniprot id: U5W6X0
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1246995:AFR RS26360
gene id: 1246995:AFR_RS26360
uniprot id: U5W3B2
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1246995:AFR RS10075
gene id: 1246995:AFR_RS10075
uniprot id: U5VTG5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1246995:AFR RS27845
gene id: 1246995:AFR_RS27845
uniprot id: U5W459
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1246995:AFR RS14260
gene id: 1246995:AFR_RS14260
uniprot id: U5VWG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1246995:AFR RS08290
gene id: 1246995:AFR_RS08290
uniprot id: U5VSY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS02960
gene id: 1246995:AFR_RS02960
uniprot id: U5VT85
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS13095
gene id: 1246995:AFR_RS13095
uniprot id: U5VYY4
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS43045
gene id: 1246995:AFR_RS43045
uniprot id: U5WCW5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1246995:AFR RS07945
gene id: 1246995:AFR_RS07945
uniprot id: U5VSR9
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

1246995:AFR RS21850
gene id: 1246995:AFR_RS21850
uniprot id: U5W078
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

1246995:AFR RS41455
gene id: 1246995:AFR_RS41455
uniprot id: U5WBB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS21235
gene id: 1246995:AFR_RS21235
uniprot id: U5W3B1
names: Similarity
messages: Belongs to the UPF0749 family.

1246995:AFR RS45830
gene id: 1246995:AFR_RS45830
uniprot id: U5VQN1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS42325
gene id: 1246995:AFR_RS42325
uniprot id: U5WFI2
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1246995:AFR RS30955
gene id: 1246995:AFR_RS30955
uniprot id: U5W903
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

1246995:AFR RS39890
gene id: 1246995:AFR_RS39890
uniprot id: U5WDU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

1246995:AFR RS04565
gene id: 1246995:AFR_RS04565
uniprot id: U5VU84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1246995:AFR RS39810
gene id: 1246995:AFR_RS39810
uniprot id: U5WAM3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS33235
gene id: 1246995:AFR_RS33235
uniprot id: U5WA63
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS05090
gene id: 1246995:AFR_RS05090
uniprot id: U5VUI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS37165
gene id: 1246995:AFR_RS37165
uniprot id: U5W945
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1246995:AFR RS14525
gene id: 1246995:AFR_RS14525
uniprot id: U5VWD6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS35260
gene id: 1246995:AFR_RS35260
uniprot id: U5W8E0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS11635
gene id: 1246995:AFR_RS11635
uniprot id: U5VY84
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS38455
gene id: 1246995:AFR_RS38455
uniprot id: U5WA54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

1246995:AFR RS15040
gene id: 1246995:AFR_RS15040
uniprot id: U5VW98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS05040
gene id: 1246995:AFR_RS05040
uniprot id: U5VUH2
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS12900
gene id: 1246995:AFR_RS12900
uniprot id: U5VVL3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS00805
gene id: 1246995:AFR_RS00805
uniprot id: U5VNS1
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

1246995:AFR RS04510
gene id: 1246995:AFR_RS04510
uniprot id: U5VTZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1246995:AFR RS33175
gene id: 1246995:AFR_RS33175
uniprot id: U5W6M3
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

1246995:AFR RS17755
gene id: 1246995:AFR_RS17755
uniprot id: U5W1L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS03880
gene id: 1246995:AFR_RS03880
uniprot id: U5VQK1
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1246995:AFR RS14695
gene id: 1246995:AFR_RS14695
uniprot id: U5VW42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS09610
gene id: 1246995:AFR_RS09610
uniprot id: U5VT88
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS14245
gene id: 1246995:AFR_RS14245
uniprot id: U5VW93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1246995:AFR RS43140
gene id: 1246995:AFR_RS43140
uniprot id: U5WFW4
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS39605
gene id: 1246995:AFR_RS39605
uniprot id: U5WAC4
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1246995:AFR RS23555
gene id: 1246995:AFR_RS23555
uniprot id: U5W4M5
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

1246995:AFR RS25810
gene id: 1246995:AFR_RS25810
uniprot id: U5W619
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS35100
gene id: 1246995:AFR_RS35100
uniprot id: U5WB87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

1246995:AFR RS05820
gene id: 1246995:AFR_RS05820
uniprot id: U5VUN1
names: Similarity
messages: Belongs to the EfeM/EfeO family.

1246995:AFR RS20180
gene id: 1246995:AFR_RS20180
uniprot id: U5VZF9
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS15290
gene id: 1246995:AFR_RS15290
uniprot id: U5VWE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial phospholipase C family.
messages: cell wall

1246995:AFR RS14440
gene id: 1246995:AFR_RS14440
uniprot id: U5VWJ3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

1246995:AFR RS31745
gene id: 1246995:AFR_RS31745
uniprot id: U5W9J8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

1246995:AFR RS36500
gene id: 1246995:AFR_RS36500
uniprot id: U5WC32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A probable RNA-binding protein.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm

1246995:AFR RS02970
gene id: 1246995:AFR_RS02970
uniprot id: U5VPH8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS00160
gene id: 1246995:AFR_RS00160
uniprot id: U5VRG6
names: Similarity
messages: Belongs to the heat shock protein 90 family.

1246995:AFR RS02575
gene id: 1246995:AFR_RS02575
uniprot id: U5VPR5
names: Similarity
messages: Belongs to the WXG100 family.

1246995:AFR RS25575
gene id: 1246995:AFR_RS25575
uniprot id: U5W5S8
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS15340
gene id: 1246995:AFR_RS15340
uniprot id: U5VWF2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS13365
gene id: 1246995:AFR_RS13365
uniprot id: U5VYY0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS07155
gene id: 1246995:AFR_RS07155
uniprot id: U5VRV5
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1246995:AFR RS25535
gene id: 1246995:AFR_RS25535
uniprot id: U5W2V0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1246995:AFR RS11015
gene id: 1246995:AFR_RS11015
uniprot id: U5VUH7
names: Similarity
messages: Belongs to the glutamine synthetase family.

1246995:AFR RS04645
gene id: 1246995:AFR_RS04645
uniprot id: U5VQX4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1246995:AFR RS04720
gene id: 1246995:AFR_RS04720
uniprot id: U5VQY8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS23680
gene id: 1246995:AFR_RS23680
uniprot id: U5W4P9
names: Similarity
messages: Belongs to the AHA1 family.

1246995:AFR RS09735
gene id: 1246995:AFR_RS09735
uniprot id: U5VTM5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

1246995:AFR RS34620
gene id: 1246995:AFR_RS34620
uniprot id: U5W7I4
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS38835
gene id: 1246995:AFR_RS38835
uniprot id: U5WDF4
names: Similarity
names: Subunit
messages: Belongs to the sigma-70 factor family. ECF subfamily.
messages: Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.

1246995:AFR RS27230
gene id: 1246995:AFR_RS27230
uniprot id: U5W3T6
names: Similarity
names: Subunit
messages: Belongs to the aminoglycoside phosphotransferase family.
messages: Monomer.

1246995:AFR RS01735
gene id: 1246995:AFR_RS01735
uniprot id: U5VSM0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1246995:AFR RS07475
gene id: 1246995:AFR_RS07475
uniprot id: U5VSH5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1246995:AFR RS09075
gene id: 1246995:AFR_RS09075
uniprot id: U5VWK9
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS07175
gene id: 1246995:AFR_RS07175
uniprot id: U5VSC0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1246995:AFR RS41885
gene id: 1246995:AFR_RS41885
uniprot id: U5WF05
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1246995:AFR RS10785
gene id: 1246995:AFR_RS10785
uniprot id: U5VXN1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

1246995:AFR RS31735
gene id: 1246995:AFR_RS31735
uniprot id: U5W636
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1246995:AFR RS00610
gene id: 1246995:AFR_RS00610
uniprot id: U5VNN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS36775
gene id: 1246995:AFR_RS36775
uniprot id: U5WCD5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1246995:AFR RS10465
gene id: 1246995:AFR_RS10465
uniprot id: U5VU73
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

1246995:AFR RS10945
gene id: 1246995:AFR_RS10945
uniprot id: U5VTY1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1246995:AFR RS18795
gene id: 1246995:AFR_RS18795
uniprot id: U5VYE4
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

1246995:AFR RS05200
gene id: 1246995:AFR_RS05200
uniprot id: U5VQS3
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

1246995:AFR RS10825
gene id: 1246995:AFR_RS10825
uniprot id: U5VU83
names: Similarity
messages: Belongs to the IlvD/Edd family.

1246995:AFR RS10585
gene id: 1246995:AFR_RS10585
uniprot id: U5VXJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

1246995:AFR RS03355
gene id: 1246995:AFR_RS03355
uniprot id: U5VTG1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS19110
gene id: 1246995:AFR_RS19110
uniprot id: U5W276
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS09765
gene id: 1246995:AFR_RS09765
uniprot id: U5VWX8
names: Similarity
messages: Belongs to the threonine aldolase family.

1246995:AFR RS15285
gene id: 1246995:AFR_RS15285
uniprot id: U5VX04
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS04660
gene id: 1246995:AFR_RS04660
uniprot id: U5VU23
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1246995:AFR RS27760
gene id: 1246995:AFR_RS27760
uniprot id: U5W727
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS36560
gene id: 1246995:AFR_RS36560
uniprot id: U5W8K1
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1246995:AFR RS30590
gene id: 1246995:AFR_RS30590
uniprot id: U5W550
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1246995:AFR RS43830
gene id: 1246995:AFR_RS43830
uniprot id: U5W191
names: Caution
names: Similarity
messages: Belongs to the peptidase S8 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS31065
gene id: 1246995:AFR_RS31065
uniprot id: U5W5F4
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1246995:AFR RS10680
gene id: 1246995:AFR_RS10680
uniprot id: U5VXE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

1246995:AFR RS10005
gene id: 1246995:AFR_RS10005
uniprot id: U5VTE9
names: Similarity
messages: Belongs to the peptidase S8 family.

1246995:AFR RS31845
gene id: 1246995:AFR_RS31845
uniprot id: U5W9L4
names: Similarity
messages: Belongs to the selenium-binding protein family.

1246995:AFR RS19135
gene id: 1246995:AFR_RS19135
uniprot id: U5W279
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS10415
gene id: 1246995:AFR_RS10415
uniprot id: U5VU65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1246995:AFR RS16815
gene id: 1246995:AFR_RS16815
uniprot id: U5VXN2
names: Similarity
messages: Belongs to the cytochrome P450 family.

1246995:AFR RS14720
gene id: 1246995:AFR_RS14720
uniprot id: U5VW47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

1246995:AFR RS14855
gene id: 1246995:AFR_RS14855
uniprot id: U5VZU1
names: Similarity
messages: Belongs to the glycosyl hydrolase 11 (cellulase G) family.

1246995:AFR RS10915
gene id: 1246995:AFR_RS10915
uniprot id: U5VUF5
names: Similarity
messages: Belongs to the YciI family.

1246995:AFR RS10045
gene id: 1246995:AFR_RS10045
uniprot id: U5VX88
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS01210
gene id: 1246995:AFR_RS01210
uniprot id: U5VS76
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1246995:AFR RS11455
gene id: 1246995:AFR_RS11455
uniprot id: U5VXZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS30835
gene id: 1246995:AFR_RS30835
uniprot id: U5W5W0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

1246995:AFR RS12110
gene id: 1246995:AFR_RS12110
uniprot id: U5VV03
names: Similarity
messages: Belongs to the YciI family.

1246995:AFR RS08105
gene id: 1246995:AFR_RS08105
uniprot id: U5VSP6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1246995:AFR RS30630
gene id: 1246995:AFR_RS30630
uniprot id: U5W8T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1246995:AFR RS08785
gene id: 1246995:AFR_RS08785
uniprot id: U5VSR5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1246995:AFR RS07455
gene id: 1246995:AFR_RS07455
uniprot id: U5VS04
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1246995:AFR RS16915
gene id: 1246995:AFR_RS16915
uniprot id: U5VXP7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS08600
gene id: 1246995:AFR_RS08600
uniprot id: U5VWF0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1246995:AFR RS20405
gene id: 1246995:AFR_RS20405
uniprot id: U5VZK1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS11595
gene id: 1246995:AFR_RS11595
uniprot id: U5VUF8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1246995:AFR RS42885
gene id: 1246995:AFR_RS42885
uniprot id: U5WFS6
names: Similarity
messages: Belongs to the fructosamine kinase family.

1246995:AFR RS07320
gene id: 1246995:AFR_RS07320
uniprot id: U5VVK0
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS35315
gene id: 1246995:AFR_RS35315
uniprot id: U5W7U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1246995:AFR RS08775
gene id: 1246995:AFR_RS08775
uniprot id: U5VWI6
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

1246995:AFR RS40710
gene id: 1246995:AFR_RS40710
uniprot id: U5WEI3
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliO/MopB family.
messages: Cell membrane

1246995:AFR RS30800
gene id: 1246995:AFR_RS30800
uniprot id: U5W8S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1246995:AFR RS03245
gene id: 1246995:AFR_RS03245
uniprot id: U5VQ41
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1246995:AFR RS16800
gene id: 1246995:AFR_RS16800
uniprot id: U5W144
names: Similarity
messages: Belongs to the citrate synthase family.

1246995:AFR RS34860
gene id: 1246995:AFR_RS34860
uniprot id: U5W7M5
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1246995:AFR RS03550
gene id: 1246995:AFR_RS03550
uniprot id: U5VTC6
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

1246995:AFR RS16690
gene id: 1246995:AFR_RS16690
uniprot id: U5W134
names: Similarity
messages: Belongs to the NodU/CmcH family.

1246995:AFR RS38960
gene id: 1246995:AFR_RS38960
uniprot id: U5WDH8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS07340
gene id: 1246995:AFR_RS07340
uniprot id: U5VSA4
names: Similarity
names: Subunit
messages: Belongs to the sigma-70 factor family. ECF subfamily.
messages: Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.

1246995:AFR RS20225
gene id: 1246995:AFR_RS20225
uniprot id: U5VZ71
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS21925
gene id: 1246995:AFR_RS21925
uniprot id: U5W088
names: Subcellular Location Annotation
messages: Cell inner membrane

1246995:AFR RS17375
gene id: 1246995:AFR_RS17375
uniprot id: U5W1E3
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1246995:AFR RS19865
gene id: 1246995:AFR_RS19865
uniprot id: U5W2S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

1246995:AFR RS30670
gene id: 1246995:AFR_RS30670
uniprot id: U5W5E0
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

1246995:AFR RS03105
gene id: 1246995:AFR_RS03105
uniprot id: U5VT47
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS22880
gene id: 1246995:AFR_RS22880
uniprot id: U5W4A5
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1246995:AFR RS09685
gene id: 1246995:AFR_RS09685
uniprot id: U5VTL5
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

1246995:AFR RS36165
gene id: 1246995:AFR_RS36165
uniprot id: U5W8B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1246995:AFR RS27775
gene id: 1246995:AFR_RS27775
uniprot id: U5W3J5
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS10150
gene id: 1246995:AFR_RS10150
uniprot id: U5VTI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

1246995:AFR RS08100
gene id: 1246995:AFR_RS08100
uniprot id: U5VSB4
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1246995:AFR RS35690
gene id: 1246995:AFR_RS35690
uniprot id: U5W814
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1246995:AFR RS04545
gene id: 1246995:AFR_RS04545
uniprot id: U5VQV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1246995:AFR RS12965
gene id: 1246995:AFR_RS12965
uniprot id: U5VYQ8
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS04300
gene id: 1246995:AFR_RS04300
uniprot id: U5VU42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1246995:AFR RS12225
gene id: 1246995:AFR_RS12225
uniprot id: U5VYI5
names: Subcellular Location Annotation
messages: Cytoplasm

1246995:AFR RS20205
gene id: 1246995:AFR_RS20205
uniprot id: U5VZG3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS23190
gene id: 1246995:AFR_RS23190
uniprot id: U5W4L3
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS20615
gene id: 1246995:AFR_RS20615
uniprot id: U5W352
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS30855
gene id: 1246995:AFR_RS30855
uniprot id: U5W8Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1246995:AFR RS06255
gene id: 1246995:AFR_RS06255
uniprot id: U5VUW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

1246995:AFR RS39495
gene id: 1246995:AFR_RS39495
uniprot id: U5WDM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1246995:AFR RS40630
gene id: 1246995:AFR_RS40630
uniprot id: U5WEG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

1246995:AFR RS22825
gene id: 1246995:AFR_RS22825
uniprot id: U5W0Y2
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

1246995:AFR RS04275
gene id: 1246995:AFR_RS04275
uniprot id: U5VU37
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

1246995:AFR RS06735
gene id: 1246995:AFR_RS06735
uniprot id: U5VRP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS23835
gene id: 1246995:AFR_RS23835
uniprot id: U5W4S9
names: Similarity
messages: Belongs to the FAD-binding monooxygenase family.
messages: Belongs to the FMO family.

1246995:AFR RS34585
gene id: 1246995:AFR_RS34585
uniprot id: U5WB31
names: Similarity
messages: Belongs to the thioredoxin family.

1246995:AFR RS15965
gene id: 1246995:AFR_RS15965
uniprot id: U5VWT0
names: Subcellular Location Annotation
messages: Cytoplasm

1246995:AFR RS04655
gene id: 1246995:AFR_RS04655
uniprot id: U5VQU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1246995:AFR RS39225
gene id: 1246995:AFR_RS39225
uniprot id: U5WAC3
names: Similarity
messages: Belongs to the peptidase S51 family.

1246995:AFR RS21795
gene id: 1246995:AFR_RS21795
uniprot id: U5W3W2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS30440
gene id: 1246995:AFR_RS30440
uniprot id: U5W523
names: Similarity
messages: Belongs to the cytochrome P450 family.

1246995:AFR RS28840
gene id: 1246995:AFR_RS28840
uniprot id: U5W4D2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS24095
gene id: 1246995:AFR_RS24095
uniprot id: U5W1I6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS37160
gene id: 1246995:AFR_RS37160
uniprot id: U5W8Y5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1246995:AFR RS38070
gene id: 1246995:AFR_RS38070
uniprot id: U5W9K3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1246995:AFR RS32665
gene id: 1246995:AFR_RS32665
uniprot id: U5WA10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

1246995:AFR RS11355
gene id: 1246995:AFR_RS11355
uniprot id: U5VXW7
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

1246995:AFR RS30255
gene id: 1246995:AFR_RS30255
uniprot id: U5W8M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS05165
gene id: 1246995:AFR_RS05165
uniprot id: U5VUJ5
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

1246995:AFR RS25955
gene id: 1246995:AFR_RS25955
uniprot id: U5W5Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 3 family.
messages: Catalyzes the depolymerization of both polygalacturonate and pectins of methyl esterification degree from 22 to 89%, with an endo mode of action. In contrast to the majority of pectate lyases, displays high activity on highly methylated pectins.
messages: Secreted

1246995:AFR RS16000
gene id: 1246995:AFR_RS16000
uniprot id: U5W0F1
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1246995:AFR RS23775
gene id: 1246995:AFR_RS23775
uniprot id: U5W160
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1246995:AFR RS13615
gene id: 1246995:AFR_RS13615
uniprot id: U5VZ78
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS34955
gene id: 1246995:AFR_RS34955
uniprot id: U5W878
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS35135
gene id: 1246995:AFR_RS35135
uniprot id: U5W8B3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS39070
gene id: 1246995:AFR_RS39070
uniprot id: U5WA00
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS05930
gene id: 1246995:AFR_RS05930
uniprot id: U5VUY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1246995:AFR RS19705
gene id: 1246995:AFR_RS19705
uniprot id: U5VYY2
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS25450
gene id: 1246995:AFR_RS25450
uniprot id: U5W5V7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS03165
gene id: 1246995:AFR_RS03165
uniprot id: U5VPM2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1246995:AFR RS26615
gene id: 1246995:AFR_RS26615
uniprot id: U5W2Y8
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS08135
gene id: 1246995:AFR_RS08135
uniprot id: U5VW59
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS05910
gene id: 1246995:AFR_RS05910
uniprot id: U5VRL0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

1246995:AFR RS07915
gene id: 1246995:AFR_RS07915
uniprot id: U5VW18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1246995:AFR RS35345
gene id: 1246995:AFR_RS35345
uniprot id: U5W816
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ChdC family. Type 2 subfamily.
messages: Fe-coproporphyrin III acts as both substrate and redox cofactor.
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate.

1246995:AFR RS06050
gene id: 1246995:AFR_RS06050
uniprot id: U5VRJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Membrane

1246995:AFR RS10925
gene id: 1246995:AFR_RS10925
uniprot id: U5VUA0
names: Similarity
messages: Belongs to the AHA1 family.

1246995:AFR RS04685
gene id: 1246995:AFR_RS04685
uniprot id: U5VU27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1246995:AFR RS24810
gene id: 1246995:AFR_RS24810
uniprot id: U5W246
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1246995:AFR RS26340
gene id: 1246995:AFR_RS26340
uniprot id: U5W2P6
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS24125
gene id: 1246995:AFR_RS24125
uniprot id: U5W1U1
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

1246995:AFR RS12425
gene id: 1246995:AFR_RS12425
uniprot id: U5VVB6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS11740
gene id: 1246995:AFR_RS11740
uniprot id: U5VV01
names: Similarity
messages: Belongs to the YciI family.

1246995:AFR RS22505
gene id: 1246995:AFR_RS22505
uniprot id: U5W432
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

1246995:AFR RS37405
gene id: 1246995:AFR_RS37405
uniprot id: U5W9J9
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

1246995:AFR RS16240
gene id: 1246995:AFR_RS16240
uniprot id: U5VXI9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.

1246995:AFR RS05035
gene id: 1246995:AFR_RS05035
uniprot id: U5VU90
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1246995:AFR RS27060
gene id: 1246995:AFR_RS27060
uniprot id: U5W3Q3
names: Similarity
messages: Belongs to the FGGY kinase family.

1246995:AFR RS40500
gene id: 1246995:AFR_RS40500
uniprot id: U5WE59
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS05780
gene id: 1246995:AFR_RS05780
uniprot id: U5VRI5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1246995:AFR RS10120
gene id: 1246995:AFR_RS10120
uniprot id: U5VU03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

1246995:AFR RS40510
gene id: 1246995:AFR_RS40510
uniprot id: U5WBF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyltransferase group 1 family. MshA subfamily.
messages: Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
messages: Homodimer.

1246995:AFR RS05560
gene id: 1246995:AFR_RS05560
uniprot id: U5VQY7
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1246995:AFR RS09715
gene id: 1246995:AFR_RS09715
uniprot id: U5VWX0
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS35800
gene id: 1246995:AFR_RS35800
uniprot id: U5WBK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS36490
gene id: 1246995:AFR_RS36490
uniprot id: U5W8P3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1246995:AFR RS29395
gene id: 1246995:AFR_RS29395
uniprot id: U5W869
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS32410
gene id: 1246995:AFR_RS32410
uniprot id: U5W9W6
names: Similarity
messages: Belongs to the F420H(2)-dependent quinone reductase family.

1246995:AFR RS26240
gene id: 1246995:AFR_RS26240
uniprot id: U5W386
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1246995:AFR RS17855
gene id: 1246995:AFR_RS17855
uniprot id: U5W1G6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS19555
gene id: 1246995:AFR_RS19555
uniprot id: U5VYV8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1246995:AFR RS04670
gene id: 1246995:AFR_RS04670
uniprot id: U5VQX9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1246995:AFR RS15960
gene id: 1246995:AFR_RS15960
uniprot id: U5VXD8
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS36415
gene id: 1246995:AFR_RS36415
uniprot id: U5W8N3
names: Similarity
messages: Belongs to the DprA/Smf family.

1246995:AFR RS01725
gene id: 1246995:AFR_RS01725
uniprot id: U5VPA6
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.

1246995:AFR RS08170
gene id: 1246995:AFR_RS08170
uniprot id: U5VSC9
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

1246995:AFR RS18735
gene id: 1246995:AFR_RS18735
uniprot id: U5W229
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS29570
gene id: 1246995:AFR_RS29570
uniprot id: U5W8A2
names: Similarity
messages: Belongs to the AfsR/DnrI/RedD regulatory family.

1246995:AFR RS14625
gene id: 1246995:AFR_RS14625
uniprot id: U5VWF3
names: Subcellular Location Annotation
messages: Cytoplasm

1246995:AFR RS30775
gene id: 1246995:AFR_RS30775
uniprot id: U5W8R7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

1246995:AFR RS18330
gene id: 1246995:AFR_RS18330
uniprot id: U5W1Q3
names: Similarity
messages: Belongs to the peptidase S15 family.

1246995:AFR RS12795
gene id: 1246995:AFR_RS12795
uniprot id: U5VYT1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS07930
gene id: 1246995:AFR_RS07930
uniprot id: U5VSL2
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1246995:AFR RS31235
gene id: 1246995:AFR_RS31235
uniprot id: U5W640
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

1246995:AFR RS28430
gene id: 1246995:AFR_RS28430
uniprot id: U5W4H8
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS25755
gene id: 1246995:AFR_RS25755
uniprot id: U5W5V9
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS27370
gene id: 1246995:AFR_RS27370
uniprot id: U5W6V0
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

1246995:AFR RS30230
gene id: 1246995:AFR_RS30230
uniprot id: U5W8L7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS11950
gene id: 1246995:AFR_RS11950
uniprot id: U5VUL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS11325
gene id: 1246995:AFR_RS11325
uniprot id: U5VUI9
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

1246995:AFR RS08300
gene id: 1246995:AFR_RS08300
uniprot id: U5VST5
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1246995:AFR RS37080
gene id: 1246995:AFR_RS37080
uniprot id: U5W8X0
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1246995:AFR RS30065
gene id: 1246995:AFR_RS30065
uniprot id: U5W4W2
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1246995:AFR RS30150
gene id: 1246995:AFR_RS30150
uniprot id: U5W8F3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1246995:AFR RS34310
gene id: 1246995:AFR_RS34310
uniprot id: U5WAY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm

1246995:AFR RS03590
gene id: 1246995:AFR_RS03590
uniprot id: U5VPW4
names: Similarity
messages: Belongs to the AHA1 family.

1246995:AFR RS01090
gene id: 1246995:AFR_RS01090
uniprot id: U5VNX1
names: Similarity
messages: Belongs to the YciI family.

1246995:AFR RS08090
gene id: 1246995:AFR_RS08090
uniprot id: U5VW51
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS04665
gene id: 1246995:AFR_RS04665
uniprot id: U5VUA1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1246995:AFR RS36390
gene id: 1246995:AFR_RS36390
uniprot id: U5W8M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1246995:AFR RS40580
gene id: 1246995:AFR_RS40580
uniprot id: U5WEG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

1246995:AFR RS36385
gene id: 1246995:AFR_RS36385
uniprot id: U5W8G2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS02835
gene id: 1246995:AFR_RS02835
uniprot id: U5VT64
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

1246995:AFR RS11725
gene id: 1246995:AFR_RS11725
uniprot id: U5VUU2
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1246995:AFR RS21880
gene id: 1246995:AFR_RS21880
uniprot id: U5W0I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS31210
gene id: 1246995:AFR_RS31210
uniprot id: U5W635
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

1246995:AFR RS30375
gene id: 1246995:AFR_RS30375
uniprot id: U5W8J8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS04650
gene id: 1246995:AFR_RS04650
uniprot id: U5VQI2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1246995:AFR RS01295
gene id: 1246995:AFR_RS01295
uniprot id: U5VNL3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS42580
gene id: 1246995:AFR_RS42580
uniprot id: U5WFB1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1246995:AFR RS32770
gene id: 1246995:AFR_RS32770
uniprot id: U5WA25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SsgA family.
messages: Cell septum

1246995:AFR RS07985
gene id: 1246995:AFR_RS07985
uniprot id: U5VVW5
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS36475
gene id: 1246995:AFR_RS36475
uniprot id: U5WC29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1246995:AFR RS02670
gene id: 1246995:AFR_RS02670
uniprot id: U5VPB8
names: Similarity
messages: Belongs to the peptidase S66 family.

1246995:AFR RS23720
gene id: 1246995:AFR_RS23720
uniprot id: U5W150
names: Similarity
messages: Belongs to the peptidase S66 family.

1246995:AFR RS37015
gene id: 1246995:AFR_RS37015
uniprot id: U5W9D2
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS04515
gene id: 1246995:AFR_RS04515
uniprot id: U5VU76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1246995:AFR RS35500
gene id: 1246995:AFR_RS35500
uniprot id: U5WBG1
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1246995:AFR RS04805
gene id: 1246995:AFR_RS04805
uniprot id: U5VQW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS24580
gene id: 1246995:AFR_RS24580
uniprot id: U5W1R0
names: Similarity
messages: Belongs to the YciI family.

1246995:AFR RS20290
gene id: 1246995:AFR_RS20290
uniprot id: U5W2Z4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

1246995:AFR RS07965
gene id: 1246995:AFR_RS07965
uniprot id: U5VW26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1246995:AFR RS41000
gene id: 1246995:AFR_RS41000
uniprot id: U5WB89
names: Similarity
messages: Belongs to the PhoU family.
messages: Belongs to the UPF0111 family.

1246995:AFR RS10665
gene id: 1246995:AFR_RS10665
uniprot id: U5VUA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm

1246995:AFR RS10230
gene id: 1246995:AFR_RS10230
uniprot id: U5VTW3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1246995:AFR RS40670
gene id: 1246995:AFR_RS40670
uniprot id: U5WAU8
names: Similarity
messages: Belongs to the FlgD family.

1246995:AFR RS03160
gene id: 1246995:AFR_RS03160
uniprot id: U5VQ22
names: Similarity
messages: Belongs to the LOR family.

1246995:AFR RS26560
gene id: 1246995:AFR_RS26560
uniprot id: U5W3G9
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1246995:AFR RS41750
gene id: 1246995:AFR_RS41750
uniprot id: U5WC76
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1246995:AFR RS08070
gene id: 1246995:AFR_RS08070
uniprot id: U5VSU1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS24500
gene id: 1246995:AFR_RS24500
uniprot id: U5W2A0
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS09520
gene id: 1246995:AFR_RS09520
uniprot id: U5VWT2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS35960
gene id: 1246995:AFR_RS35960
uniprot id: U5W8S0
names: Similarity
messages: Belongs to the FPG family.

1246995:AFR RS24610
gene id: 1246995:AFR_RS24610
uniprot id: U5W219
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.

1246995:AFR RS19860
gene id: 1246995:AFR_RS19860
uniprot id: U5W2K4
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

1246995:AFR RS16160
gene id: 1246995:AFR_RS16160
uniprot id: U5W0M6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS43055
gene id: 1246995:AFR_RS43055
uniprot id: U5WCD4
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS34705
gene id: 1246995:AFR_RS34705
uniprot id: U5W7R4
names: Similarity
messages: Belongs to the peptidase S8 family.

1246995:AFR RS09280
gene id: 1246995:AFR_RS09280
uniprot id: U5VTK6
names: Similarity
messages: Belongs to the CutA family.

1246995:AFR RS36950
gene id: 1246995:AFR_RS36950
uniprot id: U5W909
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS04385
gene id: 1246995:AFR_RS04385
uniprot id: U5VQE9
names: Similarity
messages: Belongs to the YciI family.

1246995:AFR RS16680
gene id: 1246995:AFR_RS16680
uniprot id: U5VXM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GmhB family.
messages: Cytoplasm

1246995:AFR RS36195
gene id: 1246995:AFR_RS36195
uniprot id: U5W8I7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1246995:AFR RS03380
gene id: 1246995:AFR_RS03380
uniprot id: U5VTG8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1246995:AFR RS30040
gene id: 1246995:AFR_RS30040
uniprot id: U5W4W0
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS02325
gene id: 1246995:AFR_RS02325
uniprot id: U5VP52
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

1246995:AFR RS31215
gene id: 1246995:AFR_RS31215
uniprot id: U5W5J0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1246995:AFR RS41085
gene id: 1246995:AFR_RS41085
uniprot id: U5WEQ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

1246995:AFR RS27580
gene id: 1246995:AFR_RS27580
uniprot id: U5W3P3
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

1246995:AFR RS05765
gene id: 1246995:AFR_RS05765
uniprot id: U5VRE4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1246995:AFR RS32220
gene id: 1246995:AFR_RS32220
uniprot id: U5W6B6
names: Similarity
messages: Belongs to the YciI family.

1246995:AFR RS18525
gene id: 1246995:AFR_RS18525
uniprot id: U5VYI6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS05585
gene id: 1246995:AFR_RS05585
uniprot id: U5VQZ2
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1246995:AFR RS35165
gene id: 1246995:AFR_RS35165
uniprot id: U5W7S0
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1246995:AFR RS02920
gene id: 1246995:AFR_RS02920
uniprot id: U5VPG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS23450
gene id: 1246995:AFR_RS23450
uniprot id: U5W0Y9
names: Similarity
messages: Belongs to the acyl-CoA oxidase family.

1246995:AFR RS03300
gene id: 1246995:AFR_RS03300
uniprot id: U5VT82
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS01730
gene id: 1246995:AFR_RS01730
uniprot id: U5VSD8
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

1246995:AFR RS26720
gene id: 1246995:AFR_RS26720
uniprot id: U5W6I5
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS37880
gene id: 1246995:AFR_RS37880
uniprot id: U5WCX9
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1246995:AFR RS02600
gene id: 1246995:AFR_RS02600
uniprot id: U5VPR9
names: Similarity
messages: Belongs to the EccD/Snm4 family.

1246995:AFR RS32085
gene id: 1246995:AFR_RS32085
uniprot id: U5W699
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS33240
gene id: 1246995:AFR_RS33240
uniprot id: U5WAA4
names: Similarity
messages: Belongs to the UPF0225 family.

1246995:AFR RS07570
gene id: 1246995:AFR_RS07570
uniprot id: U5VSJ4
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1246995:AFR RS46695
gene id: 1246995:AFR_RS46695
uniprot id: U5VSM2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1246995:AFR RS09410
gene id: 1246995:AFR_RS09410
uniprot id: U5VT57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS43035
gene id: 1246995:AFR_RS43035
uniprot id: U5WFJ8
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1246995:AFR RS22690
gene id: 1246995:AFR_RS22690
uniprot id: U5W187
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS11380
gene id: 1246995:AFR_RS11380
uniprot id: U5VXX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

1246995:AFR RS06400
gene id: 1246995:AFR_RS06400
uniprot id: U5VRV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

1246995:AFR RS13165
gene id: 1246995:AFR_RS13165
uniprot id: U5VYU5
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS38180
gene id: 1246995:AFR_RS38180
uniprot id: U5WD29
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS42380
gene id: 1246995:AFR_RS42380
uniprot id: U5WCJ3
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS21605
gene id: 1246995:AFR_RS21605
uniprot id: U5W0E2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS19885
gene id: 1246995:AFR_RS19885
uniprot id: U5W2K9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

1246995:AFR RS23125
gene id: 1246995:AFR_RS23125
uniprot id: U5W141
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

1246995:AFR RS43110
gene id: 1246995:AFR_RS43110
uniprot id: U5WFW1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

1246995:AFR RS36485
gene id: 1246995:AFR_RS36485
uniprot id: U5W8I4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1246995:AFR RS26665
gene id: 1246995:AFR_RS26665
uniprot id: U5W2Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

1246995:AFR RS38080
gene id: 1246995:AFR_RS38080
uniprot id: U5WD13
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

1246995:AFR RS13915
gene id: 1246995:AFR_RS13915
uniprot id: U5VZC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1246995:AFR RS21410
gene id: 1246995:AFR_RS21410
uniprot id: U5W3E7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

1246995:AFR RS36470
gene id: 1246995:AFR_RS36470
uniprot id: U5WBZ2
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1246995:AFR RS21525
gene id: 1246995:AFR_RS21525
uniprot id: U5W0N4
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS31645
gene id: 1246995:AFR_RS31645
uniprot id: U5W9I1
names: Subunit
messages: Homotetramer.

1246995:AFR RS15350
gene id: 1246995:AFR_RS15350
uniprot id: U5W029
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

1246995:AFR RS37255
gene id: 1246995:AFR_RS37255
uniprot id: U5W9G9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1246995:AFR RS20580
gene id: 1246995:AFR_RS20580
uniprot id: U5VZN7
names: Function
names: Similarity
messages: Belongs to the catalase family. HPII subfamily.
messages: Serves to protect cells from the toxic effects of hydrogen peroxide.

1246995:AFR RS39185
gene id: 1246995:AFR_RS39185
uniprot id: U5WDR4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1246995:AFR RS10115
gene id: 1246995:AFR_RS10115
uniprot id: U5VXA5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS25670
gene id: 1246995:AFR_RS25670
uniprot id: U5W2L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane.

1246995:AFR RS12130
gene id: 1246995:AFR_RS12130
uniprot id: U5VUN8
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS02040
gene id: 1246995:AFR_RS02040
uniprot id: U5VSS5
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS13430
gene id: 1246995:AFR_RS13430
uniprot id: U5VVC0
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS40380
gene id: 1246995:AFR_RS40380
uniprot id: U5WEC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

1246995:AFR RS36725
gene id: 1246995:AFR_RS36725
uniprot id: U5WCC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1246995:AFR RS26725
gene id: 1246995:AFR_RS26725
uniprot id: U5W6N9
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS18520
gene id: 1246995:AFR_RS18520
uniprot id: U5VY78
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS31230
gene id: 1246995:AFR_RS31230
uniprot id: U5W959
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1246995:AFR RS15150
gene id: 1246995:AFR_RS15150
uniprot id: U5VZZ3
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS34945
gene id: 1246995:AFR_RS34945
uniprot id: U5WB59
names: Similarity
messages: Belongs to the glycosyl hydrolase 12 (cellulase H) family.

1246995:AFR RS13510
gene id: 1246995:AFR_RS13510
uniprot id: U5VZ14
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1246995:AFR RS38190
gene id: 1246995:AFR_RS38190
uniprot id: U5W9G3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

1246995:AFR RS30385
gene id: 1246995:AFR_RS30385
uniprot id: U5W5M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1246995:AFR RS10395
gene id: 1246995:AFR_RS10395
uniprot id: U5VU59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

1246995:AFR RS16995
gene id: 1246995:AFR_RS16995
uniprot id: U5W120
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

1246995:AFR RS29390
gene id: 1246995:AFR_RS29390
uniprot id: U5W818
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS14490
gene id: 1246995:AFR_RS14490
uniprot id: U5VWK2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS37680
gene id: 1246995:AFR_RS37680
uniprot id: U5W9Q4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1246995:AFR RS40600
gene id: 1246995:AFR_RS40600
uniprot id: U5WE78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

1246995:AFR RS10735
gene id: 1246995:AFR_RS10735
uniprot id: U5VXM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1246995:AFR RS13630
gene id: 1246995:AFR_RS13630
uniprot id: U5VVU2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS37480
gene id: 1246995:AFR_RS37480
uniprot id: U5W9L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS27575
gene id: 1246995:AFR_RS27575
uniprot id: U5W3G4
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

1246995:AFR RS00645
gene id: 1246995:AFR_RS00645
uniprot id: U5VRQ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

1246995:AFR RS33630
gene id: 1246995:AFR_RS33630
uniprot id: U5W736
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

1246995:AFR RS35330
gene id: 1246995:AFR_RS35330
uniprot id: U5WBG3
names: Similarity
messages: Belongs to the WrbA family.

1246995:AFR RS44280
gene id: 1246995:AFR_RS44280
uniprot id: U5WBS5
names: Similarity
messages: Belongs to the AfsR/DnrI/RedD regulatory family.

1246995:AFR RS16150
gene id: 1246995:AFR_RS16150
uniprot id: U5VX90
names: Function
names: Similarity
messages: Belongs to the bacterial two-domain DSD family.
messages: Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways.

1246995:AFR RS24765
gene id: 1246995:AFR_RS24765
uniprot id: U5W5D3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS36130
gene id: 1246995:AFR_RS36130
uniprot id: U5WBW1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS06070
gene id: 1246995:AFR_RS06070
uniprot id: U5VR88
names: Similarity
messages: Belongs to the GSP E family.

1246995:AFR RS06865
gene id: 1246995:AFR_RS06865
uniprot id: U5VRR4
names: Similarity
messages: Belongs to the AfsR/DnrI/RedD regulatory family.

1246995:AFR RS02165
gene id: 1246995:AFR_RS02165
uniprot id: U5VSU3
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.
messages: Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).

1246995:AFR RS09990
gene id: 1246995:AFR_RS09990
uniprot id: U5VX19
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1246995:AFR RS31265
gene id: 1246995:AFR_RS31265
uniprot id: U5W5K1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.
messages: Cell membrane
messages: Contains a di-nuclear catalytic Mg(2+) center.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1246995:AFR RS40635
gene id: 1246995:AFR_RS40635
uniprot id: U5WBH3
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

1246995:AFR RS32575
gene id: 1246995:AFR_RS32575
uniprot id: U5W6B8
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS37275
gene id: 1246995:AFR_RS37275
uniprot id: U5WCM3
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1246995:AFR RS24085
gene id: 1246995:AFR_RS24085
uniprot id: U5W572
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

1246995:AFR RS14425
gene id: 1246995:AFR_RS14425
uniprot id: U5VWC1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS04595
gene id: 1246995:AFR_RS04595
uniprot id: U5VQW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1246995:AFR RS06730
gene id: 1246995:AFR_RS06730
uniprot id: U5VS43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS17120
gene id: 1246995:AFR_RS17120
uniprot id: U5W143
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

1246995:AFR RS29230
gene id: 1246995:AFR_RS29230
uniprot id: U5W4G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS40675
gene id: 1246995:AFR_RS40675
uniprot id: U5WB24
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

1246995:AFR RS07635
gene id: 1246995:AFR_RS07635
uniprot id: U5VS36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1246995:AFR RS08725
gene id: 1246995:AFR_RS08725
uniprot id: U5VWH6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS28070
gene id: 1246995:AFR_RS28070
uniprot id: U5W7C4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

1246995:AFR RS41955
gene id: 1246995:AFR_RS41955
uniprot id: U5WBP4
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

1246995:AFR RS03395
gene id: 1246995:AFR_RS03395
uniprot id: U5VQ69
names: Similarity
messages: Belongs to the YciI family.

1246995:AFR RS36320
gene id: 1246995:AFR_RS36320
uniprot id: U5W8L3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

1246995:AFR RS32430
gene id: 1246995:AFR_RS32430
uniprot id: U5W9R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1246995:AFR RS20220
gene id: 1246995:AFR_RS20220
uniprot id: U5VZT5
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS31445
gene id: 1246995:AFR_RS31445
uniprot id: U5W998
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.

1246995:AFR RS35530
gene id: 1246995:AFR_RS35530
uniprot id: U5WBJ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine-5'-phosphate glycosidase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
messages: Homotrimer.

1246995:AFR RS06080
gene id: 1246995:AFR_RS06080
uniprot id: U5VUS7
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS04490
gene id: 1246995:AFR_RS04490
uniprot id: U5VTY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1246995:AFR RS23215
gene id: 1246995:AFR_RS23215
uniprot id: U5W4L9
names: Similarity
messages: Belongs to the peptidase S33 family.

1246995:AFR RS03305
gene id: 1246995:AFR_RS03305
uniprot id: U5VTF0
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS37640
gene id: 1246995:AFR_RS37640
uniprot id: U5W9C5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS03790
gene id: 1246995:AFR_RS03790
uniprot id: U5VQG5
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS23695
gene id: 1246995:AFR_RS23695
uniprot id: U5W145
names: Similarity
messages: Belongs to the peptidase S33 family.

1246995:AFR RS20795
gene id: 1246995:AFR_RS20795
uniprot id: U5W040
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

1246995:AFR RS10105
gene id: 1246995:AFR_RS10105
uniprot id: U5VTU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1246995:AFR RS37040
gene id: 1246995:AFR_RS37040
uniprot id: U5WCA3
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1246995:AFR RS37545
gene id: 1246995:AFR_RS37545
uniprot id: U5WCJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1246995:AFR RS20125
gene id: 1246995:AFR_RS20125
uniprot id: U5VZ55
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS37215
gene id: 1246995:AFR_RS37215
uniprot id: U5W953
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1246995:AFR RS35255
gene id: 1246995:AFR_RS35255
uniprot id: U5WBF0
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS20555
gene id: 1246995:AFR_RS20555
uniprot id: U5VZN0
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS36395
gene id: 1246995:AFR_RS36395
uniprot id: U5WBX4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1246995:AFR RS14065
gene id: 1246995:AFR_RS14065
uniprot id: U5VZF4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS10675
gene id: 1246995:AFR_RS10675
uniprot id: U5VU55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1246995:AFR RS21135
gene id: 1246995:AFR_RS21135
uniprot id: U5W388
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS26230
gene id: 1246995:AFR_RS26230
uniprot id: U5W6A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

1246995:AFR RS10145
gene id: 1246995:AFR_RS10145
uniprot id: U5VU09
names: Similarity
messages: Belongs to the YggT family.

1246995:AFR RS26475
gene id: 1246995:AFR_RS26475
uniprot id: U5W6A8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1246995:AFR RS24650
gene id: 1246995:AFR_RS24650
uniprot id: U5W2C6
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

1246995:AFR RS07630
gene id: 1246995:AFR_RS07630
uniprot id: U5VSK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1246995:AFR RS07380
gene id: 1246995:AFR_RS07380
uniprot id: U5VSF7
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS30025
gene id: 1246995:AFR_RS30025
uniprot id: U5W8D6
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS15615
gene id: 1246995:AFR_RS15615
uniprot id: U5VWK4
names: Similarity
messages: Belongs to the peptidase M1 family.

1246995:AFR RS37515
gene id: 1246995:AFR_RS37515
uniprot id: U5W9A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1246995:AFR RS40705
gene id: 1246995:AFR_RS40705
uniprot id: U5WE98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

1246995:AFR RS27425
gene id: 1246995:AFR_RS27425
uniprot id: U5W3E1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS12655
gene id: 1246995:AFR_RS12655
uniprot id: U5VUX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS13770
gene id: 1246995:AFR_RS13770
uniprot id: U5VW37
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1246995:AFR RS10140
gene id: 1246995:AFR_RS10140
uniprot id: U5VXB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

1246995:AFR RS09010
gene id: 1246995:AFR_RS09010
uniprot id: U5VTG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1246995:AFR RS39460
gene id: 1246995:AFR_RS39460
uniprot id: U5WA99
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS05305
gene id: 1246995:AFR_RS05305
uniprot id: U5VR62
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS09740
gene id: 1246995:AFR_RS09740
uniprot id: U5VWX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1246995:AFR RS21415
gene id: 1246995:AFR_RS21415
uniprot id: U5W3K3
names: Similarity
messages: Belongs to the IucA/IucC family.

1246995:AFR RS37235
gene id: 1246995:AFR_RS37235
uniprot id: U5W901
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS28065
gene id: 1246995:AFR_RS28065
uniprot id: U5W783
names: Function
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

1246995:AFR RS04930
gene id: 1246995:AFR_RS04930
uniprot id: U5VQY9
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS40110
gene id: 1246995:AFR_RS40110
uniprot id: U5WE85
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1246995:AFR RS24455
gene id: 1246995:AFR_RS24455
uniprot id: U5W1Z5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1246995:AFR RS20310
gene id: 1246995:AFR_RS20310
uniprot id: U5W2T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

1246995:AFR RS04940
gene id: 1246995:AFR_RS04940
uniprot id: U5VUF2
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1246995:AFR RS08780
gene id: 1246995:AFR_RS08780
uniprot id: U5VT84
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1246995:AFR RS00535
gene id: 1246995:AFR_RS00535
uniprot id: U5VNM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1246995:AFR RS31165
gene id: 1246995:AFR_RS31165
uniprot id: U5W5H7
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

1246995:AFR RS34745
gene id: 1246995:AFR_RS34745
uniprot id: U5W835
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS38195
gene id: 1246995:AFR_RS38195
uniprot id: U5W9N4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1246995:AFR RS09370
gene id: 1246995:AFR_RS09370
uniprot id: U5VWQ5
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1246995:AFR RS03095
gene id: 1246995:AFR_RS03095
uniprot id: U5VPK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS41905
gene id: 1246995:AFR_RS41905
uniprot id: U5WBN7
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS31900
gene id: 1246995:AFR_RS31900
uniprot id: U5W6I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1246995:AFR RS04630
gene id: 1246995:AFR_RS04630
uniprot id: U5VQT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1246995:AFR RS40095
gene id: 1246995:AFR_RS40095
uniprot id: U5WAK9
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1246995:AFR RS08910
gene id: 1246995:AFR_RS08910
uniprot id: U5VTF2
names: Similarity
messages: Belongs to the barstar family.

1246995:AFR RS00330
gene id: 1246995:AFR_RS00330
uniprot id: U5VMZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

1246995:AFR RS26570
gene id: 1246995:AFR_RS26570
uniprot id: U5W371
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

1246995:AFR RS23790
gene id: 1246995:AFR_RS23790
uniprot id: U5W4X6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS22405
gene id: 1246995:AFR_RS22405
uniprot id: U5W412
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS42720
gene id: 1246995:AFR_RS42720
uniprot id: U5WC23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1246995:AFR RS22365
gene id: 1246995:AFR_RS22365
uniprot id: U5W122
names: Similarity
messages: Belongs to the UPF0098 family.

1246995:AFR RS19330
gene id: 1246995:AFR_RS19330
uniprot id: U5VYS6
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

1246995:AFR RS29755
gene id: 1246995:AFR_RS29755
uniprot id: U5W599
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1246995:AFR RS40425
gene id: 1246995:AFR_RS40425
uniprot id: U5WE45
names: Cofactor
messages: Binds 1 FAD per subunit.

1246995:AFR RS35435
gene id: 1246995:AFR_RS35435
uniprot id: U5W8H6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS17070
gene id: 1246995:AFR_RS17070
uniprot id: U5W133
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS33340
gene id: 1246995:AFR_RS33340
uniprot id: U5W7B2
names: Similarity
messages: Belongs to the peptidase S9C family.

1246995:AFR RS25355
gene id: 1246995:AFR_RS25355
uniprot id: U5W248
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1246995:AFR RS12760
gene id: 1246995:AFR_RS12760
uniprot id: U5VVB7
names: Similarity
messages: Belongs to the YciI family.

1246995:AFR RS19990
gene id: 1246995:AFR_RS19990
uniprot id: U5W2U4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

1246995:AFR RS32840
gene id: 1246995:AFR_RS32840
uniprot id: U5W9Y9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1246995:AFR RS02445
gene id: 1246995:AFR_RS02445
uniprot id: U5VPM8
names: Similarity
messages: Belongs to the cysteine dioxygenase family.

1246995:AFR RS31105
gene id: 1246995:AFR_RS31105
uniprot id: U5W937
names: Function
names: Similarity
messages: Belongs to the peptidase S51 family.
messages: Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.

1246995:AFR RS40715
gene id: 1246995:AFR_RS40715
uniprot id: U5WBI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

1246995:AFR RS38820
gene id: 1246995:AFR_RS38820
uniprot id: U5W9U8
names: Function
messages: Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.

1246995:AFR RS31140
gene id: 1246995:AFR_RS31140
uniprot id: U5W5H1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS08440
gene id: 1246995:AFR_RS08440
uniprot id: U5VSW2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS22705
gene id: 1246995:AFR_RS22705
uniprot id: U5W473
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

1246995:AFR RS21365
gene id: 1246995:AFR_RS21365
uniprot id: U5W3J3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1246995:AFR RS22520
gene id: 1246995:AFR_RS22520
uniprot id: U5W0J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS16205
gene id: 1246995:AFR_RS16205
uniprot id: U5W0J2
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1246995:AFR RS42595
gene id: 1246995:AFR_RS42595
uniprot id: U5WC03
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1246995:AFR RS31110
gene id: 1246995:AFR_RS31110
uniprot id: U5W611
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS16440
gene id: 1246995:AFR_RS16440
uniprot id: U5VX75
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS24985
gene id: 1246995:AFR_RS24985
uniprot id: U5W278
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1246995:AFR RS39845
gene id: 1246995:AFR_RS39845
uniprot id: U5WE36
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1246995:AFR RS31305
gene id: 1246995:AFR_RS31305
uniprot id: U5W972
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS30390
gene id: 1246995:AFR_RS30390
uniprot id: U5W513
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1246995:AFR RS39655
gene id: 1246995:AFR_RS39655
uniprot id: U5WAD3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1246995:AFR RS34475
gene id: 1246995:AFR_RS34475
uniprot id: U5W7M6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS36235
gene id: 1246995:AFR_RS36235
uniprot id: U5W8X3
names: Similarity
messages: Belongs to the glutamine synthetase family.

1246995:AFR RS18875
gene id: 1246995:AFR_RS18875
uniprot id: U5VZ16
names: Similarity
messages: Belongs to the FAD-binding monooxygenase family.

1246995:AFR RS13910
gene id: 1246995:AFR_RS13910
uniprot id: U5VW43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1246995:AFR RS40690
gene id: 1246995:AFR_RS40690
uniprot id: U5WBI2
names: Similarity
messages: Belongs to the MotB family.

1246995:AFR RS42420
gene id: 1246995:AFR_RS42420
uniprot id: U5WCJ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1246995:AFR RS04120
gene id: 1246995:AFR_RS04120
uniprot id: U5VTS9
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS00340
gene id: 1246995:AFR_RS00340
uniprot id: U5VRJ7
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS01880
gene id: 1246995:AFR_RS01880
uniprot id: U5VSG8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1246995:AFR RS29165
gene id: 1246995:AFR_RS29165
uniprot id: U5W7X9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1246995:AFR RS15850
gene id: 1246995:AFR_RS15850
uniprot id: U5W0C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Membrane

1246995:AFR RS34820
gene id: 1246995:AFR_RS34820
uniprot id: U5WB72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1246995:AFR RS09900
gene id: 1246995:AFR_RS09900
uniprot id: U5VTW0
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

1246995:AFR RS21815
gene id: 1246995:AFR_RS21815
uniprot id: U5W3W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS38025
gene id: 1246995:AFR_RS38025
uniprot id: U5WCT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1246995:AFR RS08310
gene id: 1246995:AFR_RS08310
uniprot id: U5VW91
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS12775
gene id: 1246995:AFR_RS12775
uniprot id: U5VVI7
names: Function
names: Similarity
messages: Belongs to the UPF0677 family.
messages: Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.

1246995:AFR RS16825
gene id: 1246995:AFR_RS16825
uniprot id: U5W149
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1246995:AFR RS25615
gene id: 1246995:AFR_RS25615
uniprot id: U5W294
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS18220
gene id: 1246995:AFR_RS18220
uniprot id: U5VY16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS28130
gene id: 1246995:AFR_RS28130
uniprot id: U5W4B6
names: Similarity
messages: Belongs to the cytochrome P450 family.

1246995:AFR RS31195
gene id: 1246995:AFR_RS31195
uniprot id: U5W5Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1246995:AFR RS00180
gene id: 1246995:AFR_RS00180
uniprot id: U5VNG2
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

1246995:AFR RS36230
gene id: 1246995:AFR_RS36230
uniprot id: U5WBY3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1246995:AFR RS27895
gene id: 1246995:AFR_RS27895
uniprot id: U5W469
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1246995:AFR RS30340
gene id: 1246995:AFR_RS30340
uniprot id: U5W504
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS15550
gene id: 1246995:AFR_RS15550
uniprot id: U5W070
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1246995:AFR RS37550
gene id: 1246995:AFR_RS37550
uniprot id: U5WCS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1246995:AFR RS36375
gene id: 1246995:AFR_RS36375
uniprot id: U5WC14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

1246995:AFR RS01255
gene id: 1246995:AFR_RS01255
uniprot id: U5VS17
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1246995:AFR RS22570
gene id: 1246995:AFR_RS22570
uniprot id: U5W0J9
names: Similarity
messages: Belongs to the DapA family.

1246995:AFR RS24535
gene id: 1246995:AFR_RS24535
uniprot id: U5W208
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS00720
gene id: 1246995:AFR_RS00720
uniprot id: U5VRR9
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

1246995:AFR RS40730
gene id: 1246995:AFR_RS40730
uniprot id: U5WEA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

1246995:AFR RS27805
gene id: 1246995:AFR_RS27805
uniprot id: U5W3T8
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS42650
gene id: 1246995:AFR_RS42650
uniprot id: U5WC60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

1246995:AFR RS35985
gene id: 1246995:AFR_RS35985
uniprot id: U5W8S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1246995:AFR RS06485
gene id: 1246995:AFR_RS06485
uniprot id: U5VVC7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

1246995:AFR RS35160
gene id: 1246995:AFR_RS35160
uniprot id: U5W8B9
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

1246995:AFR RS31360
gene id: 1246995:AFR_RS31360
uniprot id: U5W5M2
names: Subcellular Location Annotation
messages: Cytoplasm

1246995:AFR RS20755
gene id: 1246995:AFR_RS20755
uniprot id: U5VZS3
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS36865
gene id: 1246995:AFR_RS36865
uniprot id: U5W8Z6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1246995:AFR RS30075
gene id: 1246995:AFR_RS30075
uniprot id: U5W8E5
names: Similarity
messages: Belongs to the TlyA family.

1246995:AFR RS38665
gene id: 1246995:AFR_RS38665
uniprot id: U5WA92
names: Subcellular Location Annotation
messages: Cytoplasm

1246995:AFR RS04295
gene id: 1246995:AFR_RS04295
uniprot id: U5VTV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1246995:AFR RS21190
gene id: 1246995:AFR_RS21190
uniprot id: U5W3G1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS18970
gene id: 1246995:AFR_RS18970
uniprot id: U5VYJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS02100
gene id: 1246995:AFR_RS02100
uniprot id: U5VP21
names: Similarity
messages: Belongs to the peptidase C56 family.

1246995:AFR RS06575
gene id: 1246995:AFR_RS06575
uniprot id: U5VRL9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS33335
gene id: 1246995:AFR_RS33335
uniprot id: U5WAC5
names: Similarity
messages: Belongs to the asparagine synthetase family.

1246995:AFR RS02260
gene id: 1246995:AFR_RS02260
uniprot id: U5VSN9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.

1246995:AFR RS39900
gene id: 1246995:AFR_RS39900
uniprot id: U5WB28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1246995:AFR RS06445
gene id: 1246995:AFR_RS06445
uniprot id: U5VRJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1246995:AFR RS03500
gene id: 1246995:AFR_RS03500
uniprot id: U5VTB5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1246995:AFR RS26480
gene id: 1246995:AFR_RS26480
uniprot id: U5W6E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1246995:AFR RS26225
gene id: 1246995:AFR_RS26225
uniprot id: U5W648
names: Similarity
messages: Belongs to the peptidase M1 family.

1246995:AFR RS29340
gene id: 1246995:AFR_RS29340
uniprot id: U5W810
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS20430
gene id: 1246995:AFR_RS20430
uniprot id: U5VZK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1246995:AFR RS16430
gene id: 1246995:AFR_RS16430
uniprot id: U5W0Y8
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS29530
gene id: 1246995:AFR_RS29530
uniprot id: U5W4L2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS32815
gene id: 1246995:AFR_RS32815
uniprot id: U5W9Y4
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS43060
gene id: 1246995:AFR_RS43060
uniprot id: U5WFK3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

1246995:AFR RS17920
gene id: 1246995:AFR_RS17920
uniprot id: U5VYH5
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1246995:AFR RS19715
gene id: 1246995:AFR_RS19715
uniprot id: U5W2H6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS25205
gene id: 1246995:AFR_RS25205
uniprot id: U5W220
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS00445
gene id: 1246995:AFR_RS00445
uniprot id: U5VRL8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1246995:AFR RS40950
gene id: 1246995:AFR_RS40950
uniprot id: U5WB80
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. MshD subfamily.
messages: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1246995:AFR RS30170
gene id: 1246995:AFR_RS30170
uniprot id: U5W543
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1246995:AFR RS09415
gene id: 1246995:AFR_RS09415
uniprot id: U5VTH5
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

1246995:AFR RS07730
gene id: 1246995:AFR_RS07730
uniprot id: U5VSH2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1246995:AFR RS09140
gene id: 1246995:AFR_RS09140
uniprot id: U5VWT6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1246995:AFR RS08705
gene id: 1246995:AFR_RS08705
uniprot id: U5VT72
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1246995:AFR RS30380
gene id: 1246995:AFR_RS30380
uniprot id: U5W8P1
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

1246995:AFR RS00945
gene id: 1246995:AFR_RS00945
uniprot id: U5VNU6
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1246995:AFR RS09675
gene id: 1246995:AFR_RS09675
uniprot id: U5VTR9
names: Similarity
messages: Belongs to the FAD-binding monooxygenase family.
messages: Belongs to the FMO family.

1246995:AFR RS04620
gene id: 1246995:AFR_RS04620
uniprot id: U5VQW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1246995:AFR RS27525
gene id: 1246995:AFR_RS27525
uniprot id: U5W3F8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1246995:AFR RS30860
gene id: 1246995:AFR_RS30860
uniprot id: U5W5W5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1246995:AFR RS32475
gene id: 1246995:AFR_RS32475
uniprot id: U5W6F1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1246995:AFR RS37505
gene id: 1246995:AFR_RS37505
uniprot id: U5W9L8
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

1246995:AFR RS39660
gene id: 1246995:AFR_RS39660
uniprot id: U5WAK0
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS32875
gene id: 1246995:AFR_RS32875
uniprot id: U5W723
names: Similarity
messages: Belongs to the peptidase S1 family.

1246995:AFR RS20370
gene id: 1246995:AFR_RS20370
uniprot id: U5VZW5
names: Similarity
messages: Belongs to the AAA ATPase family.

1246995:AFR RS05965
gene id: 1246995:AFR_RS05965
uniprot id: U5VR68
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

1246995:AFR RS13330
gene id: 1246995:AFR_RS13330
uniprot id: U5VV98
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1246995:AFR RS02300
gene id: 1246995:AFR_RS02300
uniprot id: U5VP47
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1246995:AFR RS40685
gene id: 1246995:AFR_RS40685
uniprot id: U5WEH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

1246995:AFR RS30765
gene id: 1246995:AFR_RS30765
uniprot id: U5W587
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS42360
gene id: 1246995:AFR_RS42360
uniprot id: U5WBW3
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS18355
gene id: 1246995:AFR_RS18355
uniprot id: U5W1Q8
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1246995:AFR RS09385
gene id: 1246995:AFR_RS09385
uniprot id: U5VT53
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

1246995:AFR RS20690
gene id: 1246995:AFR_RS20690
uniprot id: U5W364
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS01760
gene id: 1246995:AFR_RS01760
uniprot id: U5VSM4
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS38440
gene id: 1246995:AFR_RS38440
uniprot id: U5W9T5
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

1246995:AFR RS35995
gene id: 1246995:AFR_RS35995
uniprot id: U5W8F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

1246995:AFR RS04580
gene id: 1246995:AFR_RS04580
uniprot id: U5VQT0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1246995:AFR RS14775
gene id: 1246995:AFR_RS14775
uniprot id: U5VWH7
names: Similarity
messages: Belongs to the peptidase S33 family.

1246995:AFR RS36695
gene id: 1246995:AFR_RS36695
uniprot id: U5WC52
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

1246995:AFR RS40370
gene id: 1246995:AFR_RS40370
uniprot id: U5WAW3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1246995:AFR RS10495
gene id: 1246995:AFR_RS10495
uniprot id: U5VTP3
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS33155
gene id: 1246995:AFR_RS33155
uniprot id: U5W6T2
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1246995:AFR RS22170
gene id: 1246995:AFR_RS22170
uniprot id: U5W0C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Cell membrane
messages: H(+)-stimulated, divalent metal cation uptake system.

1246995:AFR RS07910
gene id: 1246995:AFR_RS07910
uniprot id: U5VVV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1246995:AFR RS02285
gene id: 1246995:AFR_RS02285
uniprot id: U5VSP4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1246995:AFR RS06425
gene id: 1246995:AFR_RS06425
uniprot id: U5VRV4
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1246995:AFR RS20900
gene id: 1246995:AFR_RS20900
uniprot id: U5VZJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Gfo/Idh/MocA family.
messages: Homotetramer.
messages: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).

1246995:AFR RS08835
gene id: 1246995:AFR_RS08835
uniprot id: U5VSU6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS39430
gene id: 1246995:AFR_RS39430
uniprot id: U5WDW0
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS25940
gene id: 1246995:AFR_RS25940
uniprot id: U5W329
names: Cofactor
messages: Can also use Mn(2+) ion.

1246995:AFR RS42625
gene id: 1246995:AFR_RS42625
uniprot id: U5WC56
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1246995:AFR RS07890
gene id: 1246995:AFR_RS07890
uniprot id: U5VW13
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1246995:AFR RS05345
gene id: 1246995:AFR_RS05345
uniprot id: U5VRA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1246995:AFR RS14915
gene id: 1246995:AFR_RS14915
uniprot id: U5VW77
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS03235
gene id: 1246995:AFR_RS03235
uniprot id: U5VQ35
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS10375
gene id: 1246995:AFR_RS10375
uniprot id: U5VTL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS26825
gene id: 1246995:AFR_RS26825
uniprot id: U5W6Q5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.

1246995:AFR RS26420
gene id: 1246995:AFR_RS26420
uniprot id: U5W312
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

1246995:AFR RS25415
gene id: 1246995:AFR_RS25415
uniprot id: U5W2F9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

1246995:AFR RS42105
gene id: 1246995:AFR_RS42105
uniprot id: U5WFE1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

1246995:AFR RS39670
gene id: 1246995:AFR_RS39670
uniprot id: U5WE04
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

1246995:AFR RS22660
gene id: 1246995:AFR_RS22660
uniprot id: U5W4C3
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1246995:AFR RS25440
gene id: 1246995:AFR_RS25440
uniprot id: U5W2G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS15025
gene id: 1246995:AFR_RS15025
uniprot id: U5VZX4
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1246995:AFR RS29620
gene id: 1246995:AFR_RS29620
uniprot id: U5W8B1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS21250
gene id: 1246995:AFR_RS21250
uniprot id: U5VZS0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1246995:AFR RS12005
gene id: 1246995:AFR_RS12005
uniprot id: U5VUY7
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1246995:AFR RS04745
gene id: 1246995:AFR_RS04745
uniprot id: U5VQZ4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS15860
gene id: 1246995:AFR_RS15860
uniprot id: U5VXB8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS03965
gene id: 1246995:AFR_RS03965
uniprot id: U5VQI6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS21840
gene id: 1246995:AFR_RS21840
uniprot id: U5W3X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS09155
gene id: 1246995:AFR_RS09155
uniprot id: U5VTD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

1246995:AFR RS43100
gene id: 1246995:AFR_RS43100
uniprot id: U5WCE4
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

1246995:AFR RS24570
gene id: 1246995:AFR_RS24570
uniprot id: U5W5G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS17830
gene id: 1246995:AFR_RS17830
uniprot id: U5W1M1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1246995:AFR RS32100
gene id: 1246995:AFR_RS32100
uniprot id: U5W6M1
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1246995:AFR RS11730
gene id: 1246995:AFR_RS11730
uniprot id: U5VY34
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

1246995:AFR RS06265
gene id: 1246995:AFR_RS06265
uniprot id: U5VRT0
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

1246995:AFR RS07790
gene id: 1246995:AFR_RS07790
uniprot id: U5VVZ7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1246995:AFR RS07830
gene id: 1246995:AFR_RS07830
uniprot id: U5VSJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1246995:AFR RS40825
gene id: 1246995:AFR_RS40825
uniprot id: U5WB57
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1246995:AFR RS25695
gene id: 1246995:AFR_RS25695
uniprot id: U5W2L5
names: Similarity
messages: Belongs to the ribulokinase family.

1246995:AFR RS42205
gene id: 1246995:AFR_RS42205
uniprot id: U5WCF7
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

1246995:AFR RS07505
gene id: 1246995:AFR_RS07505
uniprot id: U5VS16
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS40475
gene id: 1246995:AFR_RS40475
uniprot id: U5WE55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1246995:AFR RS37855
gene id: 1246995:AFR_RS37855
uniprot id: U5WCX4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS18560
gene id: 1246995:AFR_RS18560
uniprot id: U5W205
names: Similarity
messages: Belongs to the glycosyl hydrolase.

1246995:AFR RS38730
gene id: 1246995:AFR_RS38730
uniprot id: U5WD60
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS04485
gene id: 1246995:AFR_RS04485
uniprot id: U5VQR3
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1246995:AFR RS40535
gene id: 1246995:AFR_RS40535
uniprot id: U5WBF7
names: Similarity
messages: Belongs to the peptidase S8 family.

1246995:AFR RS01485
gene id: 1246995:AFR_RS01485
uniprot id: U5VSH4
names: Function
names: Similarity
messages: A cysteine desulfhydrase that generates hydrogen sulfide, H(2)S. The H(2)S produced by this enzyme modulates the balance between respiration and glycolysis, and contributes to redox homeostasis. Probably eliminates toxic levels of Cys (which can induce oxidative stress).
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family. Cds1 subfamily.

1246995:AFR RS36765
gene id: 1246995:AFR_RS36765
uniprot id: U5W8X9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1246995:AFR RS43115
gene id: 1246995:AFR_RS43115
uniprot id: U5WCX6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS41755
gene id: 1246995:AFR_RS41755
uniprot id: U5WBL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

1246995:AFR RS05595
gene id: 1246995:AFR_RS05595
uniprot id: U5VUJ3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.
messages: Belongs to the MshB deacetylase family. Mca subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Monomer.

1246995:AFR RS04310
gene id: 1246995:AFR_RS04310
uniprot id: U5VQD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

1246995:AFR RS07110
gene id: 1246995:AFR_RS07110
uniprot id: U5VRU9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS14365
gene id: 1246995:AFR_RS14365
uniprot id: U5VWH8
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS05145
gene id: 1246995:AFR_RS05145
uniprot id: U5VR69
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1246995:AFR RS24350
gene id: 1246995:AFR_RS24350
uniprot id: U5W1Y0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS07785
gene id: 1246995:AFR_RS07785
uniprot id: U5VVS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1246995:AFR RS35610
gene id: 1246995:AFR_RS35610
uniprot id: U5W8K9
names: Similarity
messages: Belongs to the histone deacetylase family.

1246995:AFR RS39680
gene id: 1246995:AFR_RS39680
uniprot id: U5WAD8
names: Similarity
messages: Belongs to the UPRTase family.

1246995:AFR RS05865
gene id: 1246995:AFR_RS05865
uniprot id: U5VRG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1246995:AFR RS37020
gene id: 1246995:AFR_RS37020
uniprot id: U5W8V9
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1246995:AFR RS36285
gene id: 1246995:AFR_RS36285
uniprot id: U5W8Y1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS01405
gene id: 1246995:AFR_RS01405
uniprot id: U5VS88
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS07450
gene id: 1246995:AFR_RS07450
uniprot id: U5VSH0
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

1246995:AFR RS15175
gene id: 1246995:AFR_RS15175
uniprot id: U5VZZ7
names: Similarity
messages: Belongs to the YciI family.

1246995:AFR RS20815
gene id: 1246995:AFR_RS20815
uniprot id: U5W390
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS41295
gene id: 1246995:AFR_RS41295
uniprot id: U5WBU8
names: Similarity
messages: Belongs to the heat shock protein 70 family.

1246995:AFR RS26910
gene id: 1246995:AFR_RS26910
uniprot id: U5W341
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS33440
gene id: 1246995:AFR_RS33440
uniprot id: U5WAE4
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

1246995:AFR RS19355
gene id: 1246995:AFR_RS19355
uniprot id: U5VYS9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

1246995:AFR RS43400
gene id: 1246995:AFR_RS43400
uniprot id: U5VRR1
names: Similarity
messages: Belongs to the peptidase S8 family.

1246995:AFR RS38735
gene id: 1246995:AFR_RS38735
uniprot id: U5WDD8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS09445
gene id: 1246995:AFR_RS09445
uniprot id: U5VWS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

1246995:AFR RS40720
gene id: 1246995:AFR_RS40720
uniprot id: U5WAW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

1246995:AFR RS31245
gene id: 1246995:AFR_RS31245
uniprot id: U5VXL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

1246995:AFR RS40375
gene id: 1246995:AFR_RS40375
uniprot id: U5WE37
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1246995:AFR RS02625
gene id: 1246995:AFR_RS02625
uniprot id: U5VPS4
names: Similarity
messages: Belongs to the AfsR/DnrI/RedD regulatory family.

1246995:AFR RS41580
gene id: 1246995:AFR_RS41580
uniprot id: U5WBE5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS05920
gene id: 1246995:AFR_RS05920
uniprot id: U5VRG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

1246995:AFR RS33670
gene id: 1246995:AFR_RS33670
uniprot id: U5W7H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS38325
gene id: 1246995:AFR_RS38325
uniprot id: U5WD54
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

1246995:AFR RS35940
gene id: 1246995:AFR_RS35940
uniprot id: U5W867
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

1246995:AFR RS14845
gene id: 1246995:AFR_RS14845
uniprot id: U5VW65
names: Similarity
messages: Belongs to the AHA1 family.

1246995:AFR RS34020
gene id: 1246995:AFR_RS34020
uniprot id: U5W7P9
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS24750
gene id: 1246995:AFR_RS24750
uniprot id: U5W2E6
names: Similarity
messages: Belongs to the tannase family.

1246995:AFR RS20075
gene id: 1246995:AFR_RS20075
uniprot id: U5VZ46
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS07580
gene id: 1246995:AFR_RS07580
uniprot id: U5VSE7
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase Eis family.
messages: Homohexamer; trimer of dimers.

1246995:AFR RS27800
gene id: 1246995:AFR_RS27800
uniprot id: U5W3K1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS27660
gene id: 1246995:AFR_RS27660
uniprot id: U5W708
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1246995:AFR RS05525
gene id: 1246995:AFR_RS05525
uniprot id: U5VUQ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1246995:AFR RS20210
gene id: 1246995:AFR_RS20210
uniprot id: U5W2S1
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

1246995:AFR RS41115
gene id: 1246995:AFR_RS41115
uniprot id: U5WBR1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS12790
gene id: 1246995:AFR_RS12790
uniprot id: U5VYM4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1246995:AFR RS04610
gene id: 1246995:AFR_RS04610
uniprot id: U5VU12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1246995:AFR RS30660
gene id: 1246995:AFR_RS30660
uniprot id: U5W5S5
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1246995:AFR RS38400
gene id: 1246995:AFR_RS38400
uniprot id: U5WD68
names: Similarity
messages: Belongs to the disproportionating enzyme family.

1246995:AFR RS35380
gene id: 1246995:AFR_RS35380
uniprot id: U5WBH1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1246995:AFR RS11990
gene id: 1246995:AFR_RS11990
uniprot id: U5VYE5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1246995:AFR RS33060
gene id: 1246995:AFR_RS33060
uniprot id: U5W6R0
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1246995:AFR RS02630
gene id: 1246995:AFR_RS02630
uniprot id: U5VSV4
names: Similarity
messages: Belongs to the AfsR/DnrI/RedD regulatory family.

1246995:AFR RS42005
gene id: 1246995:AFR_RS42005
uniprot id: U5WBQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS34615
gene id: 1246995:AFR_RS34615
uniprot id: U5W811
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS35895
gene id: 1246995:AFR_RS35895
uniprot id: U5W8C9
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS32655
gene id: 1246995:AFR_RS32655
uniprot id: U5W6I2
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS28390
gene id: 1246995:AFR_RS28390
uniprot id: U5W455
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS05095
gene id: 1246995:AFR_RS05095
uniprot id: U5VR59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS20745
gene id: 1246995:AFR_RS20745
uniprot id: U5W031
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1246995:AFR RS02370
gene id: 1246995:AFR_RS02370
uniprot id: U5VPL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

1246995:AFR RS03510
gene id: 1246995:AFR_RS03510
uniprot id: U5VQ89
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1246995:AFR RS05620
gene id: 1246995:AFR_RS05620
uniprot id: U5VUJ7
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1246995:AFR RS01460
gene id: 1246995:AFR_RS01460
uniprot id: U5VSG9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS39820
gene id: 1246995:AFR_RS39820
uniprot id: U5WE31
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS32090
gene id: 1246995:AFR_RS32090
uniprot id: U5W9K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS10515
gene id: 1246995:AFR_RS10515
uniprot id: U5VU80
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1246995:AFR RS28125
gene id: 1246995:AFR_RS28125
uniprot id: U5W7D3
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1246995:AFR RS10590
gene id: 1246995:AFR_RS10590
uniprot id: U5VU94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1246995:AFR RS20790
gene id: 1246995:AFR_RS20790
uniprot id: U5W383
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

1246995:AFR RS35865
gene id: 1246995:AFR_RS35865
uniprot id: U5W849
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1246995:AFR RS40585
gene id: 1246995:AFR_RS40585
uniprot id: U5WBG5
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

1246995:AFR RS24885
gene id: 1246995:AFR_RS24885
uniprot id: U5W260
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

1246995:AFR RS36660
gene id: 1246995:AFR_RS36660
uniprot id: U5W8Q6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1246995:AFR RS04550
gene id: 1246995:AFR_RS04550
uniprot id: U5VQG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1246995:AFR RS00715
gene id: 1246995:AFR_RS00715
uniprot id: U5VNQ6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS37985
gene id: 1246995:AFR_RS37985
uniprot id: U5W9W5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1246995:AFR RS37740
gene id: 1246995:AFR_RS37740
uniprot id: U5W984
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS04460
gene id: 1246995:AFR_RS04460
uniprot id: U5VTY2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1246995:AFR RS38450
gene id: 1246995:AFR_RS38450
uniprot id: U5WD78
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS32970
gene id: 1246995:AFR_RS32970
uniprot id: U5WA59
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1246995:AFR RS04920
gene id: 1246995:AFR_RS04920
uniprot id: U5VR25
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1246995:AFR RS11030
gene id: 1246995:AFR_RS11030
uniprot id: U5VXL6
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

1246995:AFR RS16980
gene id: 1246995:AFR_RS16980
uniprot id: U5VXZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS30695
gene id: 1246995:AFR_RS30695
uniprot id: U5W5E5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

1246995:AFR RS32560
gene id: 1246995:AFR_RS32560
uniprot id: U5W9T6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS01765
gene id: 1246995:AFR_RS01765
uniprot id: U5VPA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

1246995:AFR RS37670
gene id: 1246995:AFR_RS37670
uniprot id: U5WCM0
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1246995:AFR RS30810
gene id: 1246995:AFR_RS30810
uniprot id: U5W5V4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS23410
gene id: 1246995:AFR_RS23410
uniprot id: U5W4J8
names: Similarity
messages: Belongs to the AHA1 family.

1246995:AFR RS36650
gene id: 1246995:AFR_RS36650
uniprot id: U5WCA6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS16945
gene id: 1246995:AFR_RS16945
uniprot id: U5W110
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

1246995:AFR RS35505
gene id: 1246995:AFR_RS35505
uniprot id: U5WBJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1246995:AFR RS06380
gene id: 1246995:AFR_RS06380
uniprot id: U5VV26
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS30510
gene id: 1246995:AFR_RS30510
uniprot id: U5W5Q0
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS46825
gene id: 1246995:AFR_RS46825
uniprot id: U5W442
names: Similarity
messages: Belongs to the universal stress protein A family.

1246995:AFR RS14885
gene id: 1246995:AFR_RS14885
uniprot id: U5W003
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS37675
gene id: 1246995:AFR_RS37675
uniprot id: U5WCU6
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

1246995:AFR RS10895
gene id: 1246995:AFR_RS10895
uniprot id: U5VTW8
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS22510
gene id: 1246995:AFR_RS22510
uniprot id: U5W4A0
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

1246995:AFR RS19020
gene id: 1246995:AFR_RS19020
uniprot id: U5VZ77
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

1246995:AFR RS30490
gene id: 1246995:AFR_RS30490
uniprot id: U5W531
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer.

1246995:AFR RS04555
gene id: 1246995:AFR_RS04555
uniprot id: U5VQS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1246995:AFR RS04915
gene id: 1246995:AFR_RS04915
uniprot id: U5VUE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

1246995:AFR RS33720
gene id: 1246995:AFR_RS33720
uniprot id: U5W7I2
names: Similarity
messages: Belongs to the peptidase S33 family.

1246995:AFR RS39315
gene id: 1246995:AFR_RS39315
uniprot id: U5WAR0
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1246995:AFR RS04425
gene id: 1246995:AFR_RS04425
uniprot id: U5VTX8
names: Similarity
messages: Belongs to the UPF0234 family.

1246995:AFR RS23550
gene id: 1246995:AFR_RS23550
uniprot id: U5W1C8
names: Function
names: Similarity
messages: Belongs to the catalase family. HPII subfamily.
messages: Serves to protect cells from the toxic effects of hydrogen peroxide.

1246995:AFR RS06370
gene id: 1246995:AFR_RS06370
uniprot id: U5VRI4
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS38815
gene id: 1246995:AFR_RS38815
uniprot id: U5WAC2
names: Function
names: Similarity
messages: Belongs to the EgtB family.
messages: Catalyzes the oxidative sulfurization of hercynine (N-alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.

1246995:AFR RS19630
gene id: 1246995:AFR_RS19630
uniprot id: U5VYW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: In the N-terminal section; belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

1246995:AFR RS41125
gene id: 1246995:AFR_RS41125
uniprot id: U5WBB5
names: Similarity
messages: Belongs to the AAA ATPase family.

1246995:AFR RS19895
gene id: 1246995:AFR_RS19895
uniprot id: U5VZL9
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS35775
gene id: 1246995:AFR_RS35775
uniprot id: U5WBK1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

1246995:AFR RS20570
gene id: 1246995:AFR_RS20570
uniprot id: U5W000
names: Similarity
messages: Belongs to the leucine-binding protein family.

1246995:AFR RS09665
gene id: 1246995:AFR_RS09665
uniprot id: U5VWW1
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1246995:AFR RS02160
gene id: 1246995:AFR_RS02160
uniprot id: U5VSL9
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

1246995:AFR RS20620
gene id: 1246995:AFR_RS20620
uniprot id: U5W008
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1246995:AFR RS12805
gene id: 1246995:AFR_RS12805
uniprot id: U5VV02
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

1246995:AFR RS42735
gene id: 1246995:AFR_RS42735
uniprot id: U5WFQ3
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

1246995:AFR RS35005
gene id: 1246995:AFR_RS35005
uniprot id: U5W887
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

1246995:AFR RS21875
gene id: 1246995:AFR_RS21875
uniprot id: U5W082
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Vgb family.
messages: Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
messages: Monomer.

1246995:AFR RS31055
gene id: 1246995:AFR_RS31055
uniprot id: U5W927
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1246995:AFR RS39735
gene id: 1246995:AFR_RS39735
uniprot id: U5WAL4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS43050
gene id: 1246995:AFR_RS43050
uniprot id: U5WC70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

1246995:AFR RS16445
gene id: 1246995:AFR_RS16445
uniprot id: U5VXI3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS04840
gene id: 1246995:AFR_RS04840
uniprot id: U5VUD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1246995:AFR RS16315
gene id: 1246995:AFR_RS16315
uniprot id: U5VXK6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS32165
gene id: 1246995:AFR_RS32165
uniprot id: U5W9L5
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

1246995:AFR RS05630
gene id: 1246995:AFR_RS05630
uniprot id: U5VRF8
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1246995:AFR RS30250
gene id: 1246995:AFR_RS30250
uniprot id: U5W8H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS00200
gene id: 1246995:AFR_RS00200
uniprot id: U5VMX4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1246995:AFR RS05020
gene id: 1246995:AFR_RS05020
uniprot id: U5VR45
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

1246995:AFR RS36820
gene id: 1246995:AFR_RS36820
uniprot id: U5WC68
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1246995:AFR RS27750
gene id: 1246995:AFR_RS27750
uniprot id: U5W3J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane.

1246995:AFR RS02255
gene id: 1246995:AFR_RS02255
uniprot id: U5VPJ9
names: Similarity
messages: Belongs to the citrate synthase family.

1246995:AFR RS25545
gene id: 1246995:AFR_RS25545
uniprot id: U5W2I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS24815
gene id: 1246995:AFR_RS24815
uniprot id: U5W5E2
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS02340
gene id: 1246995:AFR_RS02340
uniprot id: U5VSX2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS22525
gene id: 1246995:AFR_RS22525
uniprot id: U5W0T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS25170
gene id: 1246995:AFR_RS25170
uniprot id: U5W5R5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1246995:AFR RS00765
gene id: 1246995:AFR_RS00765
uniprot id: U5VNR8
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1246995:AFR RS28485
gene id: 1246995:AFR_RS28485
uniprot id: U5W3Z1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1246995:AFR RS23015
gene id: 1246995:AFR_RS23015
uniprot id: U5W1E6
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1246995:AFR RS07955
gene id: 1246995:AFR_RS07955
uniprot id: U5VSL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1246995:AFR RS04705
gene id: 1246995:AFR_RS04705
uniprot id: U5VQV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1246995:AFR RS17280
gene id: 1246995:AFR_RS17280
uniprot id: U5VY48
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1246995:AFR RS28350
gene id: 1246995:AFR_RS28350
uniprot id: U5W7H7
names: Similarity
messages: Belongs to the AfsR/DnrI/RedD regulatory family.

1246995:AFR RS27205
gene id: 1246995:AFR_RS27205
uniprot id: U5W3T0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS02995
gene id: 1246995:AFR_RS02995
uniprot id: U5VPI3
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS19255
gene id: 1246995:AFR_RS19255
uniprot id: U5VZ11
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS40280
gene id: 1246995:AFR_RS40280
uniprot id: U5WBA8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1246995:AFR RS20520
gene id: 1246995:AFR_RS20520
uniprot id: U5VZZ1
names: Similarity
messages: Belongs to the AHA1 family.

1246995:AFR RS32860
gene id: 1246995:AFR_RS32860
uniprot id: U5W6L9
names: Similarity
messages: Belongs to the glycosyl hydrolase 81 family.

1246995:AFR RS37875
gene id: 1246995:AFR_RS37875
uniprot id: U5WCR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0060 family.
messages: Cell membrane

1246995:AFR RS01300
gene id: 1246995:AFR_RS01300
uniprot id: U5VP35
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS24015
gene id: 1246995:AFR_RS24015
uniprot id: U5W218
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS00530
gene id: 1246995:AFR_RS00530
uniprot id: U5VN38
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1246995:AFR RS09510
gene id: 1246995:AFR_RS09510
uniprot id: U5VT71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

1246995:AFR RS17785
gene id: 1246995:AFR_RS17785
uniprot id: U5VYF0
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

1246995:AFR RS43160
gene id: 1246995:AFR_RS43160
uniprot id: U5WFM3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1246995:AFR RS08505
gene id: 1246995:AFR_RS08505
uniprot id: U5VT34
names: Function
messages: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.

1246995:AFR RS12985
gene id: 1246995:AFR_RS12985
uniprot id: U5VVG6
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

1246995:AFR RS04570
gene id: 1246995:AFR_RS04570
uniprot id: U5VQV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1246995:AFR RS41320
gene id: 1246995:AFR_RS41320
uniprot id: U5WBV4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1246995:AFR RS19035
gene id: 1246995:AFR_RS19035
uniprot id: U5W266
names: Similarity
messages: Belongs to the glycosyl hydrolase 42 family.

1246995:AFR RS38540
gene id: 1246995:AFR_RS38540
uniprot id: U5W9N9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1246995:AFR RS06620
gene id: 1246995:AFR_RS06620
uniprot id: U5VVF0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

1246995:AFR RS07035
gene id: 1246995:AFR_RS07035
uniprot id: U5VRT8
names: Similarity
messages: Belongs to the F420H(2)-dependent quinone reductase family.

1246995:AFR RS04700
gene id: 1246995:AFR_RS04700
uniprot id: U5VQI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1246995:AFR RS34140
gene id: 1246995:AFR_RS34140
uniprot id: U5WAV5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1246995:AFR RS21115
gene id: 1246995:AFR_RS21115
uniprot id: U5W3E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS08220
gene id: 1246995:AFR_RS08220
uniprot id: U5VSD9
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1246995:AFR RS37070
gene id: 1246995:AFR_RS37070
uniprot id: U5WCI5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS02975
gene id: 1246995:AFR_RS02975
uniprot id: U5VPZ4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1246995:AFR RS31185
gene id: 1246995:AFR_RS31185
uniprot id: U5W627
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1246995:AFR RS42685
gene id: 1246995:AFR_RS42685
uniprot id: U5WFP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1246995:AFR RS17265
gene id: 1246995:AFR_RS17265
uniprot id: U5VXV2
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

1246995:AFR RS13295
gene id: 1246995:AFR_RS13295
uniprot id: U5VZ23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS35765
gene id: 1246995:AFR_RS35765
uniprot id: U5W829
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS27520
gene id: 1246995:AFR_RS27520
uniprot id: U5W3Z2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1246995:AFR RS04505
gene id: 1246995:AFR_RS04505
uniprot id: U5VQF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1246995:AFR RS09080
gene id: 1246995:AFR_RS09080
uniprot id: U5VWS6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS19945
gene id: 1246995:AFR_RS19945
uniprot id: U5VZM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1246995:AFR RS24520
gene id: 1246995:AFR_RS24520
uniprot id: U5W5F1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS36095
gene id: 1246995:AFR_RS36095
uniprot id: U5W8G9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1246995:AFR RS41485
gene id: 1246995:AFR_RS41485
uniprot id: U5WBI4
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

1246995:AFR RS36140
gene id: 1246995:AFR_RS36140
uniprot id: U5W8B0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1246995:AFR RS10360
gene id: 1246995:AFR_RS10360
uniprot id: U5VX86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1246995:AFR RS39000
gene id: 1246995:AFR_RS39000
uniprot id: U5WA42
names: Similarity
messages: Belongs to the peptidase U62 family.

1246995:AFR RS13905
gene id: 1246995:AFR_RS13905
uniprot id: U5VVR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1246995:AFR RS26905
gene id: 1246995:AFR_RS26905
uniprot id: U5W3M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1246995:AFR RS05150
gene id: 1246995:AFR_RS05150
uniprot id: U5VQR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1246995:AFR RS41615
gene id: 1246995:AFR_RS41615
uniprot id: U5WET9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1246995:AFR RS27965
gene id: 1246995:AFR_RS27965
uniprot id: U5W7A5
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1246995:AFR RS42075
gene id: 1246995:AFR_RS42075
uniprot id: U5WFD8
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS04465
gene id: 1246995:AFR_RS04465
uniprot id: U5VU68
names: Similarity
messages: Belongs to the UPF0336 family.

1246995:AFR RS39715
gene id: 1246995:AFR_RS39715
uniprot id: U5WDR2
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

1246995:AFR RS16245
gene id: 1246995:AFR_RS16245
uniprot id: U5VWZ3
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS31905
gene id: 1246995:AFR_RS31905
uniprot id: U5W610
names: Similarity
messages: Belongs to the peptidase S15 family.

1246995:AFR RS03050
gene id: 1246995:AFR_RS03050
uniprot id: U5VPJ4
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

1246995:AFR RS03190
gene id: 1246995:AFR_RS03190
uniprot id: U5VPM7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1246995:AFR RS23875
gene id: 1246995:AFR_RS23875
uniprot id: U5W1I8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1246995:AFR RS14660
gene id: 1246995:AFR_RS14660
uniprot id: U5VZW7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

1246995:AFR RS31795
gene id: 1246995:AFR_RS31795
uniprot id: U5W9K7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1246995:AFR RS25945
gene id: 1246995:AFR_RS25945
uniprot id: U5W2G0
names: Similarity
messages: Belongs to the malate synthase family.

1246995:AFR RS39905
gene id: 1246995:AFR_RS39905
uniprot id: U5WAI0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1246995:AFR RS10660
gene id: 1246995:AFR_RS10660
uniprot id: U5VXK8
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

1246995:AFR RS07070
gene id: 1246995:AFR_RS07070
uniprot id: U5VVF1
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

1246995:AFR RS05195
gene id: 1246995:AFR_RS05195
uniprot id: U5VR80
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1246995:AFR RS40695
gene id: 1246995:AFR_RS40695
uniprot id: U5WAV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

1246995:AFR RS08860
gene id: 1246995:AFR_RS08860
uniprot id: U5VSW5
names: Similarity
messages: Belongs to the UPF0047 family.

1246995:AFR RS07640
gene id: 1246995:AFR_RS07640
uniprot id: U5VSF6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS11345
gene id: 1246995:AFR_RS11345
uniprot id: U5VU91
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1246995:AFR RS39455
gene id: 1246995:AFR_RS39455
uniprot id: U5WDW5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS09020
gene id: 1246995:AFR_RS09020
uniprot id: U5VTB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS14990
gene id: 1246995:AFR_RS14990
uniprot id: U5VW90
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1246995:AFR RS11155
gene id: 1246995:AFR_RS11155
uniprot id: U5VXN8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS08985
gene id: 1246995:AFR_RS08985
uniprot id: U5VTG4
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1246995:AFR RS35970
gene id: 1246995:AFR_RS35970
uniprot id: U5W8E6
names: Similarity
messages: Belongs to the PspA/IM30 family.

1246995:AFR RS00630
gene id: 1246995:AFR_RS00630
uniprot id: U5VN61
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

1246995:AFR RS26425
gene id: 1246995:AFR_RS26425
uniprot id: U5W696
names: Similarity
messages: Belongs to the AHA1 family.

1246995:AFR RS19740
gene id: 1246995:AFR_RS19740
uniprot id: U5W2I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1246995:AFR RS00910
gene id: 1246995:AFR_RS00910
uniprot id: U5VRU8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm

1246995:AFR RS35350
gene id: 1246995:AFR_RS35350
uniprot id: U5WBD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

1246995:AFR RS36790
gene id: 1246995:AFR_RS36790
uniprot id: U5W8Y3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1246995:AFR RS05730
gene id: 1246995:AFR_RS05730
uniprot id: U5VRH5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1246995:AFR RS35440
gene id: 1246995:AFR_RS35440
uniprot id: U5W7W7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1246995:AFR RS41305
gene id: 1246995:AFR_RS41305
uniprot id: U5WBF4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1246995:AFR RS40615
gene id: 1246995:AFR_RS40615
uniprot id: U5WAT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

1246995:AFR RS40140
gene id: 1246995:AFR_RS40140
uniprot id: U5WB77
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

1246995:AFR RS42815
gene id: 1246995:AFR_RS42815
uniprot id: U5WCS1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

1246995:AFR RS38795
gene id: 1246995:AFR_RS38795
uniprot id: U5W9U2
names: Similarity
messages: Belongs to the AHA1 family.

1246995:AFR RS23425
gene id: 1246995:AFR_RS23425
uniprot id: U5W0Y4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic Ku family.
messages: Homodimer. Interacts with LigD.
messages: With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

1246995:AFR RS02305
gene id: 1246995:AFR_RS02305
uniprot id: U5VPK9
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

1246995:AFR RS39405
gene id: 1246995:AFR_RS39405
uniprot id: U5WDV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1246995:AFR RS27105
gene id: 1246995:AFR_RS27105
uniprot id: U5W6V5
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1246995:AFR RS30295
gene id: 1246995:AFR_RS30295
uniprot id: U5W565
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS32425
gene id: 1246995:AFR_RS32425
uniprot id: U5W6E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1246995:AFR RS37530
gene id: 1246995:AFR_RS37530
uniprot id: U5W9M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1246995:AFR RS22780
gene id: 1246995:AFR_RS22780
uniprot id: U5W487
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1246995:AFR RS11760
gene id: 1246995:AFR_RS11760
uniprot id: U5VYA6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS11305
gene id: 1246995:AFR_RS11305
uniprot id: U5VXR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS13920
gene id: 1246995:AFR_RS13920
uniprot id: U5VZI3
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS34245
gene id: 1246995:AFR_RS34245
uniprot id: U5W7C6
names: Similarity
messages: Belongs to the peptidase S8 family.

1246995:AFR RS39555
gene id: 1246995:AFR_RS39555
uniprot id: U5WAB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS41355
gene id: 1246995:AFR_RS41355
uniprot id: U5WBG2
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

1246995:AFR RS37245
gene id: 1246995:AFR_RS37245
uniprot id: U5WCE1
names: Similarity
messages: Belongs to the heat shock protein 70 family.

1246995:AFR RS11195
gene id: 1246995:AFR_RS11195
uniprot id: U5VUL0
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1246995:AFR RS01370
gene id: 1246995:AFR_RS01370
uniprot id: U5VNP9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

1246995:AFR RS10095
gene id: 1246995:AFR_RS10095
uniprot id: U5VTZ8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS19605
gene id: 1246995:AFR_RS19605
uniprot id: U5VYW5
names: Similarity
messages: Belongs to the F420H(2)-dependent quinone reductase family.

1246995:AFR RS06085
gene id: 1246995:AFR_RS06085
uniprot id: U5VV09
names: Similarity
messages: Belongs to the peptidase M7 family.

1246995:AFR RS37485
gene id: 1246995:AFR_RS37485
uniprot id: U5W944
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

1246995:AFR RS31470
gene id: 1246995:AFR_RS31470
uniprot id: U5W9A3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS17200
gene id: 1246995:AFR_RS17200
uniprot id: U5W1B6
names: Similarity
messages: Belongs to the AHA1 family.

1246995:AFR RS00695
gene id: 1246995:AFR_RS00695
uniprot id: U5VRR5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1246995:AFR RS08285
gene id: 1246995:AFR_RS08285
uniprot id: U5VW87
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1246995:AFR RS28195
gene id: 1246995:AFR_RS28195
uniprot id: U5W7A4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

1246995:AFR RS00700
gene id: 1246995:AFR_RS00700
uniprot id: U5VRX7
names: Similarity
messages: Belongs to the GARS family.

1246995:AFR RS44050
gene id: 1246995:AFR_RS44050
uniprot id: U5W4Q0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

1246995:AFR RS18840
gene id: 1246995:AFR_RS18840
uniprot id: U5W201
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

1246995:AFR RS13595
gene id: 1246995:AFR_RS13595
uniprot id: U5VW04
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS18025
gene id: 1246995:AFR_RS18025
uniprot id: U5VXY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

1246995:AFR RS09835
gene id: 1246995:AFR_RS09835
uniprot id: U5VTP2
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1246995:AFR RS33890
gene id: 1246995:AFR_RS33890
uniprot id: U5WAM6
names: Similarity
messages: Belongs to the peptidase M1 family.

1246995:AFR RS10295
gene id: 1246995:AFR_RS10295
uniprot id: U5VU39
names: Similarity
names: Subunit
messages: Belongs to the sigma-70 factor family. ECF subfamily.
messages: Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.

1246995:AFR RS12025
gene id: 1246995:AFR_RS12025
uniprot id: U5VUM4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS20675
gene id: 1246995:AFR_RS20675
uniprot id: U5VZE7
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS36020
gene id: 1246995:AFR_RS36020
uniprot id: U5W8F5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

1246995:AFR RS34355
gene id: 1246995:AFR_RS34355
uniprot id: U5WAU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS28090
gene id: 1246995:AFR_RS28090
uniprot id: U5W3Z4
names: Cofactor
messages: Binds 4 [4Fe-4S] clusters per subunit.

1246995:AFR RS31725
gene id: 1246995:AFR_RS31725
uniprot id: U5W6F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

1246995:AFR RS03010
gene id: 1246995:AFR_RS03010
uniprot id: U5VT26
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS40185
gene id: 1246995:AFR_RS40185
uniprot id: U5WB88
names: Similarity
messages: Belongs to the thioredoxin family.

1246995:AFR RS40250
gene id: 1246995:AFR_RS40250
uniprot id: U5WE15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

1246995:AFR RS08685
gene id: 1246995:AFR_RS08685
uniprot id: U5VSP2
names: Similarity
messages: Belongs to the SurE nucleotidase family.

1246995:AFR RS04880
gene id: 1246995:AFR_RS04880
uniprot id: U5VQY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

1246995:AFR RS36525
gene id: 1246995:AFR_RS36525
uniprot id: U5WC37
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS41430
gene id: 1246995:AFR_RS41430
uniprot id: U5WBB3
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

1246995:AFR RS15000
gene id: 1246995:AFR_RS15000
uniprot id: U5VZX0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS04480
gene id: 1246995:AFR_RS04480
uniprot id: U5VQF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1246995:AFR RS10710
gene id: 1246995:AFR_RS10710
uniprot id: U5VXL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

1246995:AFR RS19610
gene id: 1246995:AFR_RS19610
uniprot id: U5VZ66
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS40310
gene id: 1246995:AFR_RS40310
uniprot id: U5WAN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

1246995:AFR RS24450
gene id: 1246995:AFR_RS24450
uniprot id: U5W1P2
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

1246995:AFR RS20965
gene id: 1246995:AFR_RS20965
uniprot id: U5W3C0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1246995:AFR RS04245
gene id: 1246995:AFR_RS04245
uniprot id: U5VTU9
names: Similarity
messages: Belongs to the group II decarboxylase family.

1246995:AFR RS22390
gene id: 1246995:AFR_RS22390
uniprot id: U5W127
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS41380
gene id: 1246995:AFR_RS41380
uniprot id: U5WBG6
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS07650
gene id: 1246995:AFR_RS07650
uniprot id: U5VVX5
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

1246995:AFR RS10410
gene id: 1246995:AFR_RS10410
uniprot id: U5VXG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1246995:AFR RS05180
gene id: 1246995:AFR_RS05180
uniprot id: U5VR38
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

1246995:AFR RS36465
gene id: 1246995:AFR_RS36465
uniprot id: U5W8P0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1246995:AFR RS12515
gene id: 1246995:AFR_RS12515
uniprot id: U5VYI0
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS22460
gene id: 1246995:AFR_RS22460
uniprot id: U5W491
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein SsuA/TauA family.
messages: Periplasm

1246995:AFR RS02930
gene id: 1246995:AFR_RS02930
uniprot id: U5VT10
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1246995:AFR RS05490
gene id: 1246995:AFR_RS05490
uniprot id: U5VR96
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS25840
gene id: 1246995:AFR_RS25840
uniprot id: U5W308
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

1246995:AFR RS14150
gene id: 1246995:AFR_RS14150
uniprot id: U5VWE8
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS07315
gene id: 1246995:AFR_RS07315
uniprot id: U5VSA0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS23345
gene id: 1246995:AFR_RS23345
uniprot id: U5W1K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1246995:AFR RS32640
gene id: 1246995:AFR_RS32640
uniprot id: U5WA06
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS05070
gene id: 1246995:AFR_RS05070
uniprot id: U5VR54
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS14950
gene id: 1246995:AFR_RS14950
uniprot id: U5VZW0
names: Similarity
messages: Belongs to the AfsR/DnrI/RedD regulatory family.

1246995:AFR RS09540
gene id: 1246995:AFR_RS09540
uniprot id: U5VTJ3
names: Caution
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 heme c groups covalently per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.

1246995:AFR RS03960
gene id: 1246995:AFR_RS03960
uniprot id: U5VQ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

1246995:AFR RS42645
gene id: 1246995:AFR_RS42645
uniprot id: U5WC13
names: Similarity
messages: Belongs to the FPG family.

1246995:AFR RS11040
gene id: 1246995:AFR_RS11040
uniprot id: U5VUI1
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1246995:AFR RS00780
gene id: 1246995:AFR_RS00780
uniprot id: U5VNR5
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1246995:AFR RS18460
gene id: 1246995:AFR_RS18460
uniprot id: U5W1Y7
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS29385
gene id: 1246995:AFR_RS29385
uniprot id: U5W4S0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1246995:AFR RS13460
gene id: 1246995:AFR_RS13460
uniprot id: U5VVQ6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS30640
gene id: 1246995:AFR_RS30640
uniprot id: U5W561
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS00930
gene id: 1246995:AFR_RS00930
uniprot id: U5VNU8
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

1246995:AFR RS07980
gene id: 1246995:AFR_RS07980
uniprot id: U5VSM3
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS33530
gene id: 1246995:AFR_RS33530
uniprot id: U5WAB4
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS04240
gene id: 1246995:AFR_RS04240
uniprot id: U5VQM8
names: Similarity
messages: Belongs to the ComB family.

1246995:AFR RS06570
gene id: 1246995:AFR_RS06570
uniprot id: U5VS23
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.
messages: Membrane

1246995:AFR RS26260
gene id: 1246995:AFR_RS26260
uniprot id: U5W6A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS30890
gene id: 1246995:AFR_RS30890
uniprot id: U5W5B5
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

1246995:AFR RS20305
gene id: 1246995:AFR_RS20305
uniprot id: U5VZI1
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS25760
gene id: 1246995:AFR_RS25760
uniprot id: U5W607
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS28600
gene id: 1246995:AFR_RS28600
uniprot id: U5W7N0
names: Similarity
names: Subunit
messages: Belongs to the sigma-70 factor family. ECF subfamily.
messages: Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.

1246995:AFR RS39100
gene id: 1246995:AFR_RS39100
uniprot id: U5WA62
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1246995:AFR RS34605
gene id: 1246995:AFR_RS34605
uniprot id: U5WAZ6
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS30655
gene id: 1246995:AFR_RS30655
uniprot id: U5W8U1
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1246995:AFR RS22685
gene id: 1246995:AFR_RS22685
uniprot id: U5W4C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS37500
gene id: 1246995:AFR_RS37500
uniprot id: U5WCR4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS02950
gene id: 1246995:AFR_RS02950
uniprot id: U5VPY8
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS06450
gene id: 1246995:AFR_RS06450
uniprot id: U5VRV8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1246995:AFR RS36370
gene id: 1246995:AFR_RS36370
uniprot id: U5WBW9
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

1246995:AFR RS42020
gene id: 1246995:AFR_RS42020
uniprot id: U5WFC9
names: Similarity
messages: Belongs to the DnaX/STICHEL family.

1246995:AFR RS08190
gene id: 1246995:AFR_RS08190
uniprot id: U5VSW4
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

1246995:AFR RS01710
gene id: 1246995:AFR_RS01710
uniprot id: U5VSL7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1246995:AFR RS09755
gene id: 1246995:AFR_RS09755
uniprot id: U5VTA9
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

1246995:AFR RS31870
gene id: 1246995:AFR_RS31870
uniprot id: U5W9L9
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS30700
gene id: 1246995:AFR_RS30700
uniprot id: U5W8Q2
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1246995:AFR RS00490
gene id: 1246995:AFR_RS00490
uniprot id: U5VRM7
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1246995:AFR RS39880
gene id: 1246995:AFR_RS39880
uniprot id: U5WAH5
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

1246995:AFR RS35520
gene id: 1246995:AFR_RS35520
uniprot id: U5W853
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1246995:AFR RS04975
gene id: 1246995:AFR_RS04975
uniprot id: U5VQN5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

1246995:AFR RS00075
gene id: 1246995:AFR_RS00075
uniprot id: U5VMV4
names: Similarity
messages: Belongs to the CFA/CMAS family.

1246995:AFR RS30740
gene id: 1246995:AFR_RS30740
uniprot id: U5W583
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1246995:AFR RS00475
gene id: 1246995:AFR_RS00475
uniprot id: U5VRU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

1246995:AFR RS14520
gene id: 1246995:AFR_RS14520
uniprot id: U5VW16
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1246995:AFR RS31675
gene id: 1246995:AFR_RS31675
uniprot id: U5W6F0
names: Function
names: Similarity
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.

1246995:AFR RS18595
gene id: 1246995:AFR_RS18595
uniprot id: U5VY96
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1246995:AFR RS26265
gene id: 1246995:AFR_RS26265
uniprot id: U5W391
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS19150
gene id: 1246995:AFR_RS19150
uniprot id: U5VYQ2
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

1246995:AFR RS04900
gene id: 1246995:AFR_RS04900
uniprot id: U5VQM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.

1246995:AFR RS44340
gene id: 1246995:AFR_RS44340
uniprot id: U5WDA9
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

1246995:AFR RS13145
gene id: 1246995:AFR_RS13145
uniprot id: U5VYZ4
names: Similarity
messages: Belongs to the extradiol ring-cleavage dioxygenase family.

1246995:AFR RS09600
gene id: 1246995:AFR_RS09600
uniprot id: U5VX17
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1246995:AFR RS01440
gene id: 1246995:AFR_RS01440
uniprot id: U5VP44
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS33475
gene id: 1246995:AFR_RS33475
uniprot id: U5W6U1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1246995:AFR RS20315
gene id: 1246995:AFR_RS20315
uniprot id: U5W2Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

1246995:AFR RS15355
gene id: 1246995:AFR_RS15355
uniprot id: U5W089
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1246995:AFR RS37930
gene id: 1246995:AFR_RS37930
uniprot id: U5WCY7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1246995:AFR RS10565
gene id: 1246995:AFR_RS10565
uniprot id: U5VU89
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1246995:AFR RS40360
gene id: 1246995:AFR_RS40360
uniprot id: U5WBC2
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1246995:AFR RS31590
gene id: 1246995:AFR_RS31590
uniprot id: U5W9B1
names: Similarity
messages: Belongs to the pirin family.

1246995:AFR RS16730
gene id: 1246995:AFR_RS16730
uniprot id: U5VXN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1246995:AFR RS19510
gene id: 1246995:AFR_RS19510
uniprot id: U5VZ52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS12105
gene id: 1246995:AFR_RS12105
uniprot id: U5VUN5
names: Similarity
messages: Belongs to the peptidase S33 family.

1246995:AFR RS10340
gene id: 1246995:AFR_RS10340
uniprot id: U5VXE9
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS08020
gene id: 1246995:AFR_RS08020
uniprot id: U5VST3
names: Similarity
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.

1246995:AFR RS06060
gene id: 1246995:AFR_RS06060
uniprot id: U5VV05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

1246995:AFR RS35815
gene id: 1246995:AFR_RS35815
uniprot id: U5W839
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

1246995:AFR RS18965
gene id: 1246995:AFR_RS18965
uniprot id: U5VZ53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1246995:AFR RS43195
gene id: 1246995:AFR_RS43195
uniprot id: U5WCY8
names: Similarity
messages: Belongs to the ParB family.

1246995:AFR RS36100
gene id: 1246995:AFR_RS36100
uniprot id: U5WBR2
names: Similarity
messages: Belongs to the ribF family.

1246995:AFR RS05380
gene id: 1246995:AFR_RS05380
uniprot id: U5VR77
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1246995:AFR RS34545
gene id: 1246995:AFR_RS34545
uniprot id: U5W7H0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.
messages: Belongs to the aromatic-ring hydroxylase family. TetX subfamily.
messages: Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.
messages: Cytoplasm
messages: Monomer.

1246995:AFR RS05230
gene id: 1246995:AFR_RS05230
uniprot id: U5VR47
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.

1246995:AFR RS04605
gene id: 1246995:AFR_RS04605
uniprot id: U5VQT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1246995:AFR RS35310
gene id: 1246995:AFR_RS35310
uniprot id: U5W8E9
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

1246995:AFR RS24185
gene id: 1246995:AFR_RS24185
uniprot id: U5W592
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1246995:AFR RS16355
gene id: 1246995:AFR_RS16355
uniprot id: U5W0T7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.
messages: Belongs to the aromatic-ring hydroxylase family. TetX subfamily.
messages: Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.
messages: Cytoplasm
messages: Monomer.

1246995:AFR RS22020
gene id: 1246995:AFR_RS22020
uniprot id: U5W0V6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1246995:AFR RS19450
gene id: 1246995:AFR_RS19450
uniprot id: U5VZD6
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

1246995:AFR RS17330
gene id: 1246995:AFR_RS17330
uniprot id: U5VY58
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS32500
gene id: 1246995:AFR_RS32500
uniprot id: U5W6F5
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

1246995:AFR RS25490
gene id: 1246995:AFR_RS25490
uniprot id: U5W2H4
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

1246995:AFR RS30850
gene id: 1246995:AFR_RS30850
uniprot id: U5W8S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

1246995:AFR RS04770
gene id: 1246995:AFR_RS04770
uniprot id: U5VQZ9
names: Function
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.

1246995:AFR RS18800
gene id: 1246995:AFR_RS18800
uniprot id: U5VYN9
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS34880
gene id: 1246995:AFR_RS34880
uniprot id: U5W861
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS01585
gene id: 1246995:AFR_RS01585
uniprot id: U5VSJ5
names: Subcellular Location Annotation
messages: Membrane

1246995:AFR RS41635
gene id: 1246995:AFR_RS41635
uniprot id: U5WBN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1246995:AFR RS30395
gene id: 1246995:AFR_RS30395
uniprot id: U5W585
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1246995:AFR RS23670
gene id: 1246995:AFR_RS23670
uniprot id: U5W140
names: Similarity
messages: Belongs to the AHA1 family.

1246995:AFR RS20425
gene id: 1246995:AFR_RS20425
uniprot id: U5VZA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.