123214:PERMA RS08660
gene id: 123214:PERMA_RS08660
uniprot id: C0QS65
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

123214:PERMA RS02800
gene id: 123214:PERMA_RS02800
uniprot id: C0QUI5
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

123214:PERMA RS07080
gene id: 123214:PERMA_RS07080
uniprot id: C0QRA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

123214:PERMA RS08025
gene id: 123214:PERMA_RS08025
uniprot id: C0QRT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

123214:PERMA RS04865
gene id: 123214:PERMA_RS04865
uniprot id: C0QQ17
names: Similarity
messages: Belongs to the GSP E family.

123214:PERMA RS00420
gene id: 123214:PERMA_RS00420
uniprot id: C0QT68
names: Similarity
messages: Belongs to the MotB family.

123214:PERMA RS01350
gene id: 123214:PERMA_RS01350
uniprot id: C0QTQ3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

123214:PERMA RS04720
gene id: 123214:PERMA_RS04720
uniprot id: C0QPY9
names: PTM
messages: Binds 1 heme c group covalently per subunit.

123214:PERMA RS02475
gene id: 123214:PERMA_RS02475
uniprot id: C0QUB9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

123214:PERMA RS08670
gene id: 123214:PERMA_RS08670
uniprot id: C0QS67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

123214:PERMA RS09955
gene id: 123214:PERMA_RS09955
uniprot id: C0QSW1
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

123214:PERMA RS09320
gene id: 123214:PERMA_RS09320
uniprot id: C0QSJ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

123214:PERMA RS03215
gene id: 123214:PERMA_RS03215
uniprot id: C0QUR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

123214:PERMA RS02310
gene id: 123214:PERMA_RS02310
uniprot id: C0QU92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

123214:PERMA RS03930
gene id: 123214:PERMA_RS03930
uniprot id: C0QPI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

123214:PERMA RS00190
gene id: 123214:PERMA_RS00190
uniprot id: C0QT22
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

123214:PERMA RS07135
gene id: 123214:PERMA_RS07135
uniprot id: C0QRB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

123214:PERMA RS00115
gene id: 123214:PERMA_RS00115
uniprot id: C0QT07
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

123214:PERMA RS03205
gene id: 123214:PERMA_RS03205
uniprot id: C0QUR7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS07090
gene id: 123214:PERMA_RS07090
uniprot id: C0QRA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

123214:PERMA RS06085
gene id: 123214:PERMA_RS06085
uniprot id: C0QQQ3
names: Similarity
messages: Belongs to the YggT family.

123214:PERMA RS09750
gene id: 123214:PERMA_RS09750
uniprot id: C0QSS1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

123214:PERMA RS01185
gene id: 123214:PERMA_RS01185
uniprot id: C0QTM2
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS07580
gene id: 123214:PERMA_RS07580
uniprot id: C0QRK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

123214:PERMA RS02115
gene id: 123214:PERMA_RS02115
uniprot id: C0QU51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

123214:PERMA RS02080
gene id: 123214:PERMA_RS02080
uniprot id: C0QU44
names: Similarity
messages: Belongs to the SCO1/2 family.

123214:PERMA RS09605
gene id: 123214:PERMA_RS09605
uniprot id: C0QSP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

123214:PERMA RS10460
gene id: 123214:PERMA_RS10460
uniprot id: C0QUE1
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

123214:PERMA RS07315
gene id: 123214:PERMA_RS07315
uniprot id: C0QRE8
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.

123214:PERMA RS07995
gene id: 123214:PERMA_RS07995
uniprot id: C0QRT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

123214:PERMA RS02535
gene id: 123214:PERMA_RS02535
uniprot id: C0QUD1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

123214:PERMA RS08280
gene id: 123214:PERMA_RS08280
uniprot id: C0QRY9
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

123214:PERMA RS08430
gene id: 123214:PERMA_RS08430
uniprot id: C0QS18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

123214:PERMA RS03130
gene id: 123214:PERMA_RS03130
uniprot id: C0QUQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

123214:PERMA RS05820
gene id: 123214:PERMA_RS05820
uniprot id: C0QQK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

123214:PERMA RS04465
gene id: 123214:PERMA_RS04465
uniprot id: C0QPT8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

123214:PERMA RS02695
gene id: 123214:PERMA_RS02695
uniprot id: C0QUG2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

123214:PERMA RS03235
gene id: 123214:PERMA_RS03235
uniprot id: C0QUS3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS08610
gene id: 123214:PERMA_RS08610
uniprot id: C0QS55
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS03705
gene id: 123214:PERMA_RS03705
uniprot id: C0QPD6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

123214:PERMA RS07820
gene id: 123214:PERMA_RS07820
uniprot id: C0QRP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

123214:PERMA RS03440
gene id: 123214:PERMA_RS03440
uniprot id: C0QP83
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

123214:PERMA RS05260
gene id: 123214:PERMA_RS05260
uniprot id: C0QQ98
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

123214:PERMA RS07585
gene id: 123214:PERMA_RS07585
uniprot id: C0QRK1
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

123214:PERMA RS05890
gene id: 123214:PERMA_RS05890
uniprot id: C0QQL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

123214:PERMA RS07660
gene id: 123214:PERMA_RS07660
uniprot id: C0QRL5
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

123214:PERMA RS05630
gene id: 123214:PERMA_RS05630
uniprot id: C0QQH2
names: Similarity
messages: Belongs to the class-I fumarase family.

123214:PERMA RS09450
gene id: 123214:PERMA_RS09450
uniprot id: C0QSL7
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

123214:PERMA RS05045
gene id: 123214:PERMA_RS05045
uniprot id: C0QQ53
names: Similarity
messages: Belongs to the HypD family.

123214:PERMA RS04555
gene id: 123214:PERMA_RS04555
uniprot id: C0QPV6
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

123214:PERMA RS07800
gene id: 123214:PERMA_RS07800
uniprot id: C0QRP3
names: Similarity
messages: Belongs to the PstS family.

123214:PERMA RS07940
gene id: 123214:PERMA_RS07940
uniprot id: C0QRS1
names: Similarity
messages: Belongs to the UPF0045 family.

123214:PERMA RS06625
gene id: 123214:PERMA_RS06625
uniprot id: C0QR09
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

123214:PERMA RS05330
gene id: 123214:PERMA_RS05330
uniprot id: C0QQB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

123214:PERMA RS07505
gene id: 123214:PERMA_RS07505
uniprot id: C0QRI5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

123214:PERMA RS03760
gene id: 123214:PERMA_RS03760
uniprot id: C0QPE7
names: Similarity
messages: Belongs to the CutA family.

123214:PERMA RS03980
gene id: 123214:PERMA_RS03980
uniprot id: C0QPJ1
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS00790
gene id: 123214:PERMA_RS00790
uniprot id: C0QTE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

123214:PERMA RS01390
gene id: 123214:PERMA_RS01390
uniprot id: C0QTQ9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

123214:PERMA RS04215
gene id: 123214:PERMA_RS04215
uniprot id: C0QPN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

123214:PERMA RS02200
gene id: 123214:PERMA_RS02200
uniprot id: C0QU69
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

123214:PERMA RS07000
gene id: 123214:PERMA_RS07000
uniprot id: C0QR84
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

123214:PERMA RS06065
gene id: 123214:PERMA_RS06065
uniprot id: C0QQP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

123214:PERMA RS09470
gene id: 123214:PERMA_RS09470
uniprot id: C0QSM1
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

123214:PERMA RS06280
gene id: 123214:PERMA_RS06280
uniprot id: C0QQU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

123214:PERMA RS03015
gene id: 123214:PERMA_RS03015
uniprot id: C0QUM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

123214:PERMA RS04710
gene id: 123214:PERMA_RS04710
uniprot id: C0QPY7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS00340
gene id: 123214:PERMA_RS00340
uniprot id: C0QT52
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

123214:PERMA RS02315
gene id: 123214:PERMA_RS02315
uniprot id: C0QU93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

123214:PERMA RS06480
gene id: 123214:PERMA_RS06480
uniprot id: C0QQY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

123214:PERMA RS10565
gene id: 123214:PERMA_RS10565
uniprot id: C0QRI4
names: Similarity
messages: Belongs to the transglycosylase Slt family.

123214:PERMA RS07485
gene id: 123214:PERMA_RS07485
uniprot id: C0QRI2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

123214:PERMA RS07070
gene id: 123214:PERMA_RS07070
uniprot id: C0QR98
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

123214:PERMA RS01190
gene id: 123214:PERMA_RS01190
uniprot id: C0QTM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

123214:PERMA RS05085
gene id: 123214:PERMA_RS05085
uniprot id: C0QQ61
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

123214:PERMA RS04780
gene id: 123214:PERMA_RS04780
uniprot id: C0QQ00
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

123214:PERMA RS01595
gene id: 123214:PERMA_RS01595
uniprot id: C0QTU9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS08720
gene id: 123214:PERMA_RS08720
uniprot id: C0QS78
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

123214:PERMA RS00470
gene id: 123214:PERMA_RS00470
uniprot id: C0QT78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

123214:PERMA RS07945
gene id: 123214:PERMA_RS07945
uniprot id: C0QRS2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

123214:PERMA RS02130
gene id: 123214:PERMA_RS02130
uniprot id: C0QU54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

123214:PERMA RS09915
gene id: 123214:PERMA_RS09915
uniprot id: C0QSV3
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

123214:PERMA RS07810
gene id: 123214:PERMA_RS07810
uniprot id: C0QRP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

123214:PERMA RS01930
gene id: 123214:PERMA_RS01930
uniprot id: C0QU14
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

123214:PERMA RS05460
gene id: 123214:PERMA_RS05460
uniprot id: C0QQD8
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

123214:PERMA RS00580
gene id: 123214:PERMA_RS00580
uniprot id: C0QTA0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

123214:PERMA RS02485
gene id: 123214:PERMA_RS02485
uniprot id: C0QUC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

123214:PERMA RS06405
gene id: 123214:PERMA_RS06405
uniprot id: C0QQW7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

123214:PERMA RS00905
gene id: 123214:PERMA_RS00905
uniprot id: C0QTG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

123214:PERMA RS00965
gene id: 123214:PERMA_RS00965
uniprot id: C0QTH7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

123214:PERMA RS09140
gene id: 123214:PERMA_RS09140
uniprot id: C0QSF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

123214:PERMA RS06960
gene id: 123214:PERMA_RS06960
uniprot id: C0QR76
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

123214:PERMA RS05570
gene id: 123214:PERMA_RS05570
uniprot id: C0QQG0
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

123214:PERMA RS07785
gene id: 123214:PERMA_RS07785
uniprot id: C0QRP0
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

123214:PERMA RS05950
gene id: 123214:PERMA_RS05950
uniprot id: C0QQM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

123214:PERMA RS08305
gene id: 123214:PERMA_RS08305
uniprot id: C0QRZ4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

123214:PERMA RS08340
gene id: 123214:PERMA_RS08340
uniprot id: C0QS00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

123214:PERMA RS00300
gene id: 123214:PERMA_RS00300
uniprot id: C0QT44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

123214:PERMA RS02235
gene id: 123214:PERMA_RS02235
uniprot id: C0QU76
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

123214:PERMA RS02915
gene id: 123214:PERMA_RS02915
uniprot id: C0QUK8
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

123214:PERMA RS00085
gene id: 123214:PERMA_RS00085
uniprot id: C0QT01
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

123214:PERMA RS00815
gene id: 123214:PERMA_RS00815
uniprot id: C0QTE7
names: Similarity
messages: Belongs to the TlyA family.

123214:PERMA RS00765
gene id: 123214:PERMA_RS00765
uniprot id: C0QTD7
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

123214:PERMA RS07145
gene id: 123214:PERMA_RS07145
uniprot id: C0QRB3
names: Cofactor
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.

123214:PERMA RS02385
gene id: 123214:PERMA_RS02385
uniprot id: C0QUA4
names: Similarity
messages: Belongs to the transglycosylase Slt family.

123214:PERMA RS09870
gene id: 123214:PERMA_RS09870
uniprot id: C0QSU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

123214:PERMA RS08005
gene id: 123214:PERMA_RS08005
uniprot id: C0QRT4
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

123214:PERMA RS08455
gene id: 123214:PERMA_RS08455
uniprot id: C0QS23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

123214:PERMA RS00880
gene id: 123214:PERMA_RS00880
uniprot id: C0QTG0
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

123214:PERMA RS05770
gene id: 123214:PERMA_RS05770
uniprot id: C0QQJ8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

123214:PERMA RS07740
gene id: 123214:PERMA_RS07740
uniprot id: C0QRN1
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS02930
gene id: 123214:PERMA_RS02930
uniprot id: C0QUL1
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane

123214:PERMA RS05055
gene id: 123214:PERMA_RS05055
uniprot id: C0QQ55
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS09850
gene id: 123214:PERMA_RS09850
uniprot id: C0QSU0
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

123214:PERMA RS03225
gene id: 123214:PERMA_RS03225
uniprot id: C0QUS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

123214:PERMA RS00415
gene id: 123214:PERMA_RS00415
uniprot id: C0QT67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

123214:PERMA RS05200
gene id: 123214:PERMA_RS05200
uniprot id: C0QQ85
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

123214:PERMA RS03075
gene id: 123214:PERMA_RS03075
uniprot id: C0QUP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

123214:PERMA RS08095
gene id: 123214:PERMA_RS08095
uniprot id: C0QRV2
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS05965
gene id: 123214:PERMA_RS05965
uniprot id: C0QQM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

123214:PERMA RS06080
gene id: 123214:PERMA_RS06080
uniprot id: C0QQQ2
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

123214:PERMA RS09200
gene id: 123214:PERMA_RS09200
uniprot id: C0QSG6
names: Similarity
messages: Belongs to the acylphosphatase family.

123214:PERMA RS00740
gene id: 123214:PERMA_RS00740
uniprot id: C0QTD2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

123214:PERMA RS06670
gene id: 123214:PERMA_RS06670
uniprot id: C0QR17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

123214:PERMA RS02490
gene id: 123214:PERMA_RS02490
uniprot id: C0QUC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

123214:PERMA RS04305
gene id: 123214:PERMA_RS04305
uniprot id: C0QPQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

123214:PERMA RS00960
gene id: 123214:PERMA_RS00960
uniprot id: C0QTH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

123214:PERMA RS00015
gene id: 123214:PERMA_RS00015
uniprot id: C0QSY6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

123214:PERMA RS01610
gene id: 123214:PERMA_RS01610
uniprot id: C0QTV2
names: Similarity
messages: Belongs to the UPF0145 family.

123214:PERMA RS05430
gene id: 123214:PERMA_RS05430
uniprot id: C0QQD2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS07855
gene id: 123214:PERMA_RS07855
uniprot id: C0QRQ4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

123214:PERMA RS09255
gene id: 123214:PERMA_RS09255
uniprot id: C0QSH9
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

123214:PERMA RS07275
gene id: 123214:PERMA_RS07275
uniprot id: C0QRE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

123214:PERMA RS06380
gene id: 123214:PERMA_RS06380
uniprot id: C0QQW3
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

123214:PERMA RS06570
gene id: 123214:PERMA_RS06570
uniprot id: C0QQZ8
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

123214:PERMA RS04015
gene id: 123214:PERMA_RS04015
uniprot id: C0QPJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

123214:PERMA RS06005
gene id: 123214:PERMA_RS06005
uniprot id: C0QQN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

123214:PERMA RS09875
gene id: 123214:PERMA_RS09875
uniprot id: C0QSU5
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS03070
gene id: 123214:PERMA_RS03070
uniprot id: C0QUP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

123214:PERMA RS00210
gene id: 123214:PERMA_RS00210
uniprot id: C0QT26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

123214:PERMA RS08325
gene id: 123214:PERMA_RS08325
uniprot id: C0QRZ8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS04105
gene id: 123214:PERMA_RS04105
uniprot id: C0QPL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

123214:PERMA RS07280
gene id: 123214:PERMA_RS07280
uniprot id: C0QRE1
names: Similarity
messages: Belongs to the UPF0758 family.

123214:PERMA RS00535
gene id: 123214:PERMA_RS00535
uniprot id: C0QT91
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

123214:PERMA RS05080
gene id: 123214:PERMA_RS05080
uniprot id: C0QQ60
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

123214:PERMA RS08090
gene id: 123214:PERMA_RS08090
uniprot id: C0QRV1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

123214:PERMA RS05995
gene id: 123214:PERMA_RS05995
uniprot id: C0QQN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

123214:PERMA RS02090
gene id: 123214:PERMA_RS02090
uniprot id: C0QU46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

123214:PERMA RS03575
gene id: 123214:PERMA_RS03575
uniprot id: C0QPB0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

123214:PERMA RS01125
gene id: 123214:PERMA_RS01125
uniprot id: C0QTL0
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

123214:PERMA RS02480
gene id: 123214:PERMA_RS02480
uniprot id: C0QUC0
names: Function
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

123214:PERMA RS00700
gene id: 123214:PERMA_RS00700
uniprot id: C0QTC4
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

123214:PERMA RS00655
gene id: 123214:PERMA_RS00655
uniprot id: C0QTB5
names: Similarity
messages: Belongs to the RecJ family.

123214:PERMA RS01130
gene id: 123214:PERMA_RS01130
uniprot id: C0QTL1
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS06460
gene id: 123214:PERMA_RS06460
uniprot id: C0QQX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

123214:PERMA RS07010
gene id: 123214:PERMA_RS07010
uniprot id: C0QR86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

123214:PERMA RS00400
gene id: 123214:PERMA_RS00400
uniprot id: C0QT64
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

123214:PERMA RS05215
gene id: 123214:PERMA_RS05215
uniprot id: C0QQ88
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

123214:PERMA RS09210
gene id: 123214:PERMA_RS09210
uniprot id: C0QSG8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

123214:PERMA RS05480
gene id: 123214:PERMA_RS05480
uniprot id: C0QQE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm

123214:PERMA RS02505
gene id: 123214:PERMA_RS02505
uniprot id: C0QUC5
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

123214:PERMA RS02705
gene id: 123214:PERMA_RS02705
uniprot id: C0QUG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

123214:PERMA RS02890
gene id: 123214:PERMA_RS02890
uniprot id: C0QUK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

123214:PERMA RS00635
gene id: 123214:PERMA_RS00635
uniprot id: C0QTB1
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

123214:PERMA RS00360
gene id: 123214:PERMA_RS00360
uniprot id: C0QT56
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

123214:PERMA RS08450
gene id: 123214:PERMA_RS08450
uniprot id: C0QS22
names: Similarity
messages: Belongs to the transketolase family.

123214:PERMA RS02455
gene id: 123214:PERMA_RS02455
uniprot id: C0QUB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

123214:PERMA RS08650
gene id: 123214:PERMA_RS08650
uniprot id: C0QS63
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

123214:PERMA RS02105
gene id: 123214:PERMA_RS02105
uniprot id: C0QU49
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

123214:PERMA RS05375
gene id: 123214:PERMA_RS05375
uniprot id: C0QQC1
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

123214:PERMA RS06865
gene id: 123214:PERMA_RS06865
uniprot id: C0QR57
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

123214:PERMA RS00435
gene id: 123214:PERMA_RS00435
uniprot id: C0QT71
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

123214:PERMA RS03160
gene id: 123214:PERMA_RS03160
uniprot id: C0QUQ8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

123214:PERMA RS00980
gene id: 123214:PERMA_RS00980
uniprot id: C0QTH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

123214:PERMA RS02110
gene id: 123214:PERMA_RS02110
uniprot id: C0QU50
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

123214:PERMA RS06995
gene id: 123214:PERMA_RS06995
uniprot id: C0QR83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

123214:PERMA RS07055
gene id: 123214:PERMA_RS07055
uniprot id: C0QR95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

123214:PERMA RS05350
gene id: 123214:PERMA_RS05350
uniprot id: C0QQB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

123214:PERMA RS04655
gene id: 123214:PERMA_RS04655
uniprot id: C0QPX6
names: Similarity
messages: Belongs to the TrpC family.

123214:PERMA RS04035
gene id: 123214:PERMA_RS04035
uniprot id: C0QPK2
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS08160
gene id: 123214:PERMA_RS08160
uniprot id: C0QRW5
names: Similarity
messages: Belongs to the RutC family.

123214:PERMA RS00590
gene id: 123214:PERMA_RS00590
uniprot id: C0QTA2
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS08035
gene id: 123214:PERMA_RS08035
uniprot id: C0QRU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

123214:PERMA RS01000
gene id: 123214:PERMA_RS01000
uniprot id: C0QTI3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

123214:PERMA RS00355
gene id: 123214:PERMA_RS00355
uniprot id: C0QT55
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

123214:PERMA RS00005
gene id: 123214:PERMA_RS00005
uniprot id: C0QSY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

123214:PERMA RS03730
gene id: 123214:PERMA_RS03730
uniprot id: C0QPE1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane

123214:PERMA RS04205
gene id: 123214:PERMA_RS04205
uniprot id: C0QPN6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS05245
gene id: 123214:PERMA_RS05245
uniprot id: C0QQ95
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS06230
gene id: 123214:PERMA_RS06230
uniprot id: C0QQT3
names: PTM
messages: Binds 1 heme c group covalently per subunit.

123214:PERMA RS01275
gene id: 123214:PERMA_RS01275
uniprot id: C0QTN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

123214:PERMA RS02985
gene id: 123214:PERMA_RS02985
uniprot id: C0QUM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

123214:PERMA RS03100
gene id: 123214:PERMA_RS03100
uniprot id: C0QUP6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS02845
gene id: 123214:PERMA_RS02845
uniprot id: C0QUJ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

123214:PERMA RS07970
gene id: 123214:PERMA_RS07970
uniprot id: C0QRS7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

123214:PERMA RS09305
gene id: 123214:PERMA_RS09305
uniprot id: C0QSI9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds 1 Fe(2+) cation per monomer.
messages: Binds 1 nickel ion per monomer.
messages: Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Monomer.

123214:PERMA RS03525
gene id: 123214:PERMA_RS03525
uniprot id: C0QPA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

123214:PERMA RS05210
gene id: 123214:PERMA_RS05210
uniprot id: C0QQ87
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

123214:PERMA RS08600
gene id: 123214:PERMA_RS08600
uniprot id: C0QS53
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

123214:PERMA RS09930
gene id: 123214:PERMA_RS09930
uniprot id: C0QSV6
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS03585
gene id: 123214:PERMA_RS03585
uniprot id: C0QPB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

123214:PERMA RS03430
gene id: 123214:PERMA_RS03430
uniprot id: C0QP81
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

123214:PERMA RS03955
gene id: 123214:PERMA_RS03955
uniprot id: C0QPI6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

123214:PERMA RS01790
gene id: 123214:PERMA_RS01790
uniprot id: C0QTY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

123214:PERMA RS08540
gene id: 123214:PERMA_RS08540
uniprot id: C0QS40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

123214:PERMA RS00110
gene id: 123214:PERMA_RS00110
uniprot id: C0QT06
names: Similarity
messages: Belongs to the pyruvate kinase family.

123214:PERMA RS06050
gene id: 123214:PERMA_RS06050
uniprot id: C0QQP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

123214:PERMA RS06620
gene id: 123214:PERMA_RS06620
uniprot id: C0QR08
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

123214:PERMA RS03770
gene id: 123214:PERMA_RS03770
uniprot id: C0QPE9
names: Similarity
messages: Belongs to the ClpA/ClpB family.

123214:PERMA RS00390
gene id: 123214:PERMA_RS00390
uniprot id: C0QT62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

123214:PERMA RS00345
gene id: 123214:PERMA_RS00345
uniprot id: C0QT53
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

123214:PERMA RS02550
gene id: 123214:PERMA_RS02550
uniprot id: C0QUD4
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

123214:PERMA RS03540
gene id: 123214:PERMA_RS03540
uniprot id: C0QPA3
names: Similarity
messages: Belongs to the FliN/MopA/SpaO family.

123214:PERMA RS06420
gene id: 123214:PERMA_RS06420
uniprot id: C0QQX0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

123214:PERMA RS00545
gene id: 123214:PERMA_RS00545
uniprot id: C0QT93
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

123214:PERMA RS00195
gene id: 123214:PERMA_RS00195
uniprot id: C0QT23
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

123214:PERMA RS06035
gene id: 123214:PERMA_RS06035
uniprot id: C0QQP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

123214:PERMA RS06055
gene id: 123214:PERMA_RS06055
uniprot id: C0QQP7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

123214:PERMA RS10095
gene id: 123214:PERMA_RS10095
uniprot id: C0QUT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

123214:PERMA RS09110
gene id: 123214:PERMA_RS09110
uniprot id: C0QSE8
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS07775
gene id: 123214:PERMA_RS07775
uniprot id: C0QRN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

123214:PERMA RS00060
gene id: 123214:PERMA_RS00060
uniprot id: C0QSZ6
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

123214:PERMA RS03090
gene id: 123214:PERMA_RS03090
uniprot id: C0QUP4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

123214:PERMA RS00925
gene id: 123214:PERMA_RS00925
uniprot id: C0QTG9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

123214:PERMA RS00515
gene id: 123214:PERMA_RS00515
uniprot id: C0QT87
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

123214:PERMA RS02610
gene id: 123214:PERMA_RS02610
uniprot id: C0QUE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

123214:PERMA RS00285
gene id: 123214:PERMA_RS00285
uniprot id: C0QT41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

123214:PERMA RS07305
gene id: 123214:PERMA_RS07305
uniprot id: C0QRE6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

123214:PERMA RS06290
gene id: 123214:PERMA_RS06290
uniprot id: C0QQU5
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

123214:PERMA RS08250
gene id: 123214:PERMA_RS08250
uniprot id: C0QRY3
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS03615
gene id: 123214:PERMA_RS03615
uniprot id: C0QPB8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

123214:PERMA RS04400
gene id: 123214:PERMA_RS04400
uniprot id: C0QPS5
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

123214:PERMA RS00785
gene id: 123214:PERMA_RS00785
uniprot id: C0QTE1
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

123214:PERMA RS01685
gene id: 123214:PERMA_RS01685
uniprot id: C0QTW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

123214:PERMA RS01020
gene id: 123214:PERMA_RS01020
uniprot id: C0QTI8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

123214:PERMA RS03245
gene id: 123214:PERMA_RS03245
uniprot id: C0QUS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

123214:PERMA RS10050
gene id: 123214:PERMA_RS10050
uniprot id: C0QSX8
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS01705
gene id: 123214:PERMA_RS01705
uniprot id: C0QTX2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

123214:PERMA RS04345
gene id: 123214:PERMA_RS04345
uniprot id: C0QPR4
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS01945
gene id: 123214:PERMA_RS01945
uniprot id: C0QU18
names: Similarity
messages: Belongs to the peptidase S49 family.

123214:PERMA RS00090
gene id: 123214:PERMA_RS00090
uniprot id: C0QT02
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

123214:PERMA RS05490
gene id: 123214:PERMA_RS05490
uniprot id: C0QQE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

123214:PERMA RS05165
gene id: 123214:PERMA_RS05165
uniprot id: C0QQ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

123214:PERMA RS04325
gene id: 123214:PERMA_RS04325
uniprot id: C0QPR0
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.

123214:PERMA RS05985
gene id: 123214:PERMA_RS05985
uniprot id: C0QQN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

123214:PERMA RS00505
gene id: 123214:PERMA_RS00505
uniprot id: C0QT85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

123214:PERMA RS09150
gene id: 123214:PERMA_RS09150
uniprot id: C0QSF6
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

123214:PERMA RS03515
gene id: 123214:PERMA_RS03515
uniprot id: C0QP98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

123214:PERMA RS09345
gene id: 123214:PERMA_RS09345
uniprot id: C0QSJ7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS09720
gene id: 123214:PERMA_RS09720
uniprot id: C0QSR5
names: Similarity
messages: Belongs to the transglycosylase Slt family.

123214:PERMA RS03035
gene id: 123214:PERMA_RS03035
uniprot id: C0QUN3
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS08165
gene id: 123214:PERMA_RS08165
uniprot id: C0QRW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

123214:PERMA RS01105
gene id: 123214:PERMA_RS01105
uniprot id: C0QTK5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

123214:PERMA RS06980
gene id: 123214:PERMA_RS06980
uniprot id: C0QR80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

123214:PERMA RS04100
gene id: 123214:PERMA_RS04100
uniprot id: C0QPL5
names: Similarity
messages: Belongs to the GSP E family.

123214:PERMA RS07160
gene id: 123214:PERMA_RS07160
uniprot id: C0QRB6
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS05945
gene id: 123214:PERMA_RS05945
uniprot id: C0QQM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

123214:PERMA RS00680
gene id: 123214:PERMA_RS00680
uniprot id: C0QTC0
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS09285
gene id: 123214:PERMA_RS09285
uniprot id: C0QSI5
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

123214:PERMA RS07105
gene id: 123214:PERMA_RS07105
uniprot id: C0QRA5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

123214:PERMA RS06585
gene id: 123214:PERMA_RS06585
uniprot id: C0QR01
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

123214:PERMA RS00165
gene id: 123214:PERMA_RS00165
uniprot id: C0QT17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

123214:PERMA RS09300
gene id: 123214:PERMA_RS09300
uniprot id: C0QSI8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).

123214:PERMA RS03465
gene id: 123214:PERMA_RS03465
uniprot id: C0QP88
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

123214:PERMA RS05030
gene id: 123214:PERMA_RS05030
uniprot id: C0QQ50
names: Similarity
messages: Belongs to the HupF/HypC family.

123214:PERMA RS08380
gene id: 123214:PERMA_RS08380
uniprot id: C0QS08
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

123214:PERMA RS06375
gene id: 123214:PERMA_RS06375
uniprot id: C0QQW2
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

123214:PERMA RS10035
gene id: 123214:PERMA_RS10035
uniprot id: C0QSX5
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

123214:PERMA RS00915
gene id: 123214:PERMA_RS00915
uniprot id: C0QTG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

123214:PERMA RS09310
gene id: 123214:PERMA_RS09310
uniprot id: C0QSJ0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

123214:PERMA RS09825
gene id: 123214:PERMA_RS09825
uniprot id: C0QST5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

123214:PERMA RS05635
gene id: 123214:PERMA_RS05635
uniprot id: C0QQH3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

123214:PERMA RS02340
gene id: 123214:PERMA_RS02340
uniprot id: C0QU98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

123214:PERMA RS06100
gene id: 123214:PERMA_RS06100
uniprot id: C0QQQ6
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

123214:PERMA RS00385
gene id: 123214:PERMA_RS00385
uniprot id: C0QT61
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

123214:PERMA RS03325
gene id: 123214:PERMA_RS03325
uniprot id: C0QP61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

123214:PERMA RS05775
gene id: 123214:PERMA_RS05775
uniprot id: C0QQJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

123214:PERMA RS09780
gene id: 123214:PERMA_RS09780
uniprot id: C0QSS7
names: Similarity
messages: Belongs to the ribF family.

123214:PERMA RS00575
gene id: 123214:PERMA_RS00575
uniprot id: C0QT99
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

123214:PERMA RS06060
gene id: 123214:PERMA_RS06060
uniprot id: C0QQP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

123214:PERMA RS07525
gene id: 123214:PERMA_RS07525
uniprot id: C0QRI9
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

123214:PERMA RS05170
gene id: 123214:PERMA_RS05170
uniprot id: C0QQ79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

123214:PERMA RS01785
gene id: 123214:PERMA_RS01785
uniprot id: C0QTY6
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

123214:PERMA RS06885
gene id: 123214:PERMA_RS06885
uniprot id: C0QR61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

123214:PERMA RS05205
gene id: 123214:PERMA_RS05205
uniprot id: C0QQ86
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS00140
gene id: 123214:PERMA_RS00140
uniprot id: C0QT12
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

123214:PERMA RS04990
gene id: 123214:PERMA_RS04990
uniprot id: C0QQ42
names: Similarity
messages: Belongs to the peptidase M24B family.

123214:PERMA RS06725
gene id: 123214:PERMA_RS06725
uniprot id: C0QR27
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

123214:PERMA RS03700
gene id: 123214:PERMA_RS03700
uniprot id: C0QPD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheZ family.
messages: Cytoplasm

123214:PERMA RS03260
gene id: 123214:PERMA_RS03260
uniprot id: C0QUS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

123214:PERMA RS09095
gene id: 123214:PERMA_RS09095
uniprot id: C0QSE5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

123214:PERMA RS04130
gene id: 123214:PERMA_RS04130
uniprot id: C0QPM1
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS10200
gene id: 123214:PERMA_RS10200
uniprot id: C0QUV4
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

123214:PERMA RS05920
gene id: 123214:PERMA_RS05920
uniprot id: C0QQM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

123214:PERMA RS04275
gene id: 123214:PERMA_RS04275
uniprot id: C0QPQ0
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

123214:PERMA RS06845
gene id: 123214:PERMA_RS06845
uniprot id: C0QR53
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

123214:PERMA RS02925
gene id: 123214:PERMA_RS02925
uniprot id: C0QUL0
names: Similarity
messages: Belongs to the Rieske iron-sulfur protein family.

123214:PERMA RS00070
gene id: 123214:PERMA_RS00070
uniprot id: C0QSZ8
names: Similarity
messages: Belongs to the UPF0047 family.

123214:PERMA RS07695
gene id: 123214:PERMA_RS07695
uniprot id: C0QRM2
names: Similarity
messages: Belongs to the peptidase C56 family.

123214:PERMA RS04585
gene id: 123214:PERMA_RS04585
uniprot id: C0QPW2
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

123214:PERMA RS00055
gene id: 123214:PERMA_RS00055
uniprot id: C0QSZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

123214:PERMA RS04005
gene id: 123214:PERMA_RS04005
uniprot id: C0QPJ6
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS09970
gene id: 123214:PERMA_RS09970
uniprot id: C0QSW4
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

123214:PERMA RS02555
gene id: 123214:PERMA_RS02555
uniprot id: C0QUD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

123214:PERMA RS10070
gene id: 123214:PERMA_RS10070
uniprot id: C0QSY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

123214:PERMA RS09810
gene id: 123214:PERMA_RS09810
uniprot id: C0QST3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

123214:PERMA RS09485
gene id: 123214:PERMA_RS09485
uniprot id: C0QSM4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

123214:PERMA RS04670
gene id: 123214:PERMA_RS04670
uniprot id: C0QPX9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

123214:PERMA RS08435
gene id: 123214:PERMA_RS08435
uniprot id: C0QS19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

123214:PERMA RS02245
gene id: 123214:PERMA_RS02245
uniprot id: C0QU79
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

123214:PERMA RS03080
gene id: 123214:PERMA_RS03080
uniprot id: C0QUP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

123214:PERMA RS04315
gene id: 123214:PERMA_RS04315
uniprot id: C0QPQ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS05880
gene id: 123214:PERMA_RS05880
uniprot id: C0QQL2
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

123214:PERMA RS01640
gene id: 123214:PERMA_RS01640
uniprot id: C0QTV8
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

123214:PERMA RS00890
gene id: 123214:PERMA_RS00890
uniprot id: C0QTG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

123214:PERMA RS05860
gene id: 123214:PERMA_RS05860
uniprot id: C0QQK9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

123214:PERMA RS00770
gene id: 123214:PERMA_RS00770
uniprot id: C0QTD8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

123214:PERMA RS02600
gene id: 123214:PERMA_RS02600
uniprot id: C0QUE3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

123214:PERMA RS08535
gene id: 123214:PERMA_RS08535
uniprot id: C0QS39
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS08080
gene id: 123214:PERMA_RS08080
uniprot id: C0QRU9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

123214:PERMA RS04045
gene id: 123214:PERMA_RS04045
uniprot id: C0QPK4
names: Similarity
messages: Belongs to the ParB family.

123214:PERMA RS02770
gene id: 123214:PERMA_RS02770
uniprot id: C0QUH9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

123214:PERMA RS02260
gene id: 123214:PERMA_RS02260
uniprot id: C0QU82
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

123214:PERMA RS04840
gene id: 123214:PERMA_RS04840
uniprot id: C0QQ12
names: Similarity
messages: Belongs to the bacterial secretin family.

123214:PERMA RS00100
gene id: 123214:PERMA_RS00100
uniprot id: C0QT04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

123214:PERMA RS00205
gene id: 123214:PERMA_RS00205
uniprot id: C0QT25
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS07730
gene id: 123214:PERMA_RS07730
uniprot id: C0QRM9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS07450
gene id: 123214:PERMA_RS07450
uniprot id: C0QRH7
names: Similarity
messages: Belongs to the GSP E family.

123214:PERMA RS07020
gene id: 123214:PERMA_RS07020
uniprot id: C0QR88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

123214:PERMA RS04210
gene id: 123214:PERMA_RS04210
uniprot id: C0QPN7
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

123214:PERMA RS01360
gene id: 123214:PERMA_RS01360
uniprot id: C0QTQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

123214:PERMA RS07030
gene id: 123214:PERMA_RS07030
uniprot id: C0QR90
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS05455
gene id: 123214:PERMA_RS05455
uniprot id: C0QQD7
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

123214:PERMA RS01180
gene id: 123214:PERMA_RS01180
uniprot id: C0QTM1
names: Similarity
messages: Belongs to the DprA/Smf family.

123214:PERMA RS05990
gene id: 123214:PERMA_RS05990
uniprot id: C0QQN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

123214:PERMA RS06900
gene id: 123214:PERMA_RS06900
uniprot id: C0QR64
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

123214:PERMA RS08490
gene id: 123214:PERMA_RS08490
uniprot id: C0QS30
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS04935
gene id: 123214:PERMA_RS04935
uniprot id: C0QQ31
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS02545
gene id: 123214:PERMA_RS02545
uniprot id: C0QUD3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

123214:PERMA RS07975
gene id: 123214:PERMA_RS07975
uniprot id: C0QRS8
names: Function
names: Similarity
messages: Belongs to the type-2 OGG1 family.
messages: Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).

123214:PERMA RS06215
gene id: 123214:PERMA_RS06215
uniprot id: C0QQT0
names: Similarity
messages: Belongs to the Nudix hydrolase family.

123214:PERMA RS03650
gene id: 123214:PERMA_RS03650
uniprot id: C0QPC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell membrane
messages: FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

123214:PERMA RS08565
gene id: 123214:PERMA_RS08565
uniprot id: C0QS45
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS04365
gene id: 123214:PERMA_RS04365
uniprot id: C0QPR8
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

123214:PERMA RS02840
gene id: 123214:PERMA_RS02840
uniprot id: C0QUJ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

123214:PERMA RS04520
gene id: 123214:PERMA_RS04520
uniprot id: C0QPU9
names: Similarity
messages: Belongs to the DEAD box helicase family.

123214:PERMA RS03580
gene id: 123214:PERMA_RS03580
uniprot id: C0QPB1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

123214:PERMA RS01055
gene id: 123214:PERMA_RS01055
uniprot id: C0QTJ5
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS01710
gene id: 123214:PERMA_RS01710
uniprot id: C0QTX3
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

123214:PERMA RS06605
gene id: 123214:PERMA_RS06605
uniprot id: C0QR05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

123214:PERMA RS00260
gene id: 123214:PERMA_RS00260
uniprot id: C0QT36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

123214:PERMA RS02540
gene id: 123214:PERMA_RS02540
uniprot id: C0QUD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

123214:PERMA RS01545
gene id: 123214:PERMA_RS01545
uniprot id: C0QTT9
names: Similarity
messages: Belongs to the Ahb/Nir family.

123214:PERMA RS03635
gene id: 123214:PERMA_RS03635
uniprot id: C0QPC2
names: Subcellular Location Annotation
messages: Periplasm

123214:PERMA RS08350
gene id: 123214:PERMA_RS08350
uniprot id: C0QS02
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

123214:PERMA RS00715
gene id: 123214:PERMA_RS00715
uniprot id: C0QTC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.
messages: In the N-terminal section; belongs to the complex I 30 kDa subunit family.
messages: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

123214:PERMA RS09530
gene id: 123214:PERMA_RS09530
uniprot id: C0QSN3
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

123214:PERMA RS05380
gene id: 123214:PERMA_RS05380
uniprot id: C0QQC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

123214:PERMA RS08415
gene id: 123214:PERMA_RS08415
uniprot id: C0QS15
names: Function
names: Similarity
messages: Belongs to the ATPase gamma chain family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

123214:PERMA RS00175
gene id: 123214:PERMA_RS00175
uniprot id: C0QT19
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

123214:PERMA RS05385
gene id: 123214:PERMA_RS05385
uniprot id: C0QQC3
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

123214:PERMA RS03610
gene id: 123214:PERMA_RS03610
uniprot id: C0QPB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Cell membrane
messages: Membrane
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

123214:PERMA RS06665
gene id: 123214:PERMA_RS06665
uniprot id: C0QR16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

123214:PERMA RS03295
gene id: 123214:PERMA_RS03295
uniprot id: C0QP55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

123214:PERMA RS06720
gene id: 123214:PERMA_RS06720
uniprot id: C0QR26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

123214:PERMA RS08510
gene id: 123214:PERMA_RS08510
uniprot id: C0QS34
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

123214:PERMA RS04640
gene id: 123214:PERMA_RS04640
uniprot id: C0QPX3
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

123214:PERMA RS08405
gene id: 123214:PERMA_RS08405
uniprot id: C0QS13
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

123214:PERMA RS03105
gene id: 123214:PERMA_RS03105
uniprot id: C0QUP7
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS09540
gene id: 123214:PERMA_RS09540
uniprot id: C0QSN5
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

123214:PERMA RS02010
gene id: 123214:PERMA_RS02010
uniprot id: C0QU30
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

123214:PERMA RS00450
gene id: 123214:PERMA_RS00450
uniprot id: C0QT74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

123214:PERMA RS04680
gene id: 123214:PERMA_RS04680
uniprot id: C0QPY1
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

123214:PERMA RS05365
gene id: 123214:PERMA_RS05365
uniprot id: C0QQB9
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

123214:PERMA RS10360
gene id: 123214:PERMA_RS10360
uniprot id: C0QUY8
names: Similarity
messages: Belongs to the type IA topoisomerase family.

123214:PERMA RS06025
gene id: 123214:PERMA_RS06025
uniprot id: C0QQP1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

123214:PERMA RS06205
gene id: 123214:PERMA_RS06205
uniprot id: C0QQS8
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaved by autocatalysis into a large and a small subunit.
messages: This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.

123214:PERMA RS00615
gene id: 123214:PERMA_RS00615
uniprot id: C0QTA7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

123214:PERMA RS06275
gene id: 123214:PERMA_RS06275
uniprot id: C0QQU2
names: Similarity
messages: Belongs to the SCO1/2 family.

123214:PERMA RS01750
gene id: 123214:PERMA_RS01750
uniprot id: C0QTX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

123214:PERMA RS06075
gene id: 123214:PERMA_RS06075
uniprot id: C0QQQ1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

123214:PERMA RS02015
gene id: 123214:PERMA_RS02015
uniprot id: C0QU31
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

123214:PERMA RS09760
gene id: 123214:PERMA_RS09760
uniprot id: C0QSS3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

123214:PERMA RS09585
gene id: 123214:PERMA_RS09585
uniprot id: C0QSP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

123214:PERMA RS04550
gene id: 123214:PERMA_RS04550
uniprot id: C0QPV5
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

123214:PERMA RS09655
gene id: 123214:PERMA_RS09655
uniprot id: C0QSQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

123214:PERMA RS04715
gene id: 123214:PERMA_RS04715
uniprot id: C0QPY8
names: PTM
messages: Binds 1 heme c group covalently per subunit.

123214:PERMA RS06070
gene id: 123214:PERMA_RS06070
uniprot id: C0QQQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

123214:PERMA RS09325
gene id: 123214:PERMA_RS09325
uniprot id: C0QSJ3
names: Similarity
messages: Belongs to the hemerythrin family.

123214:PERMA RS09460
gene id: 123214:PERMA_RS09460
uniprot id: C0QSL9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

123214:PERMA RS03950
gene id: 123214:PERMA_RS03950
uniprot id: C0QPI5
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

123214:PERMA RS06045
gene id: 123214:PERMA_RS06045
uniprot id: C0QQP5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

123214:PERMA RS06015
gene id: 123214:PERMA_RS06015
uniprot id: C0QQN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

123214:PERMA RS05250
gene id: 123214:PERMA_RS05250
uniprot id: C0QQ96
names: Similarity
messages: Belongs to the Nudix hydrolase family.

123214:PERMA RS08410
gene id: 123214:PERMA_RS08410
uniprot id: C0QS14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

123214:PERMA RS02810
gene id: 123214:PERMA_RS02810
uniprot id: C0QUI7
names: Similarity
messages: Belongs to the bacterial secretin family.

123214:PERMA RS05640
gene id: 123214:PERMA_RS05640
uniprot id: C0QQH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

123214:PERMA RS02755
gene id: 123214:PERMA_RS02755
uniprot id: C0QUH5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

123214:PERMA RS05900
gene id: 123214:PERMA_RS05900
uniprot id: C0QQL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

123214:PERMA RS02375
gene id: 123214:PERMA_RS02375
uniprot id: C0QUA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

123214:PERMA RS02510
gene id: 123214:PERMA_RS02510
uniprot id: C0QUC6
names: Similarity
messages: Belongs to the TrpF family.

123214:PERMA RS02125
gene id: 123214:PERMA_RS02125
uniprot id: C0QU53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

123214:PERMA RS05780
gene id: 123214:PERMA_RS05780
uniprot id: C0QQK0
names: Similarity
messages: Belongs to the Skp family.

123214:PERMA RS07370
gene id: 123214:PERMA_RS07370
uniprot id: C0QRF9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

123214:PERMA RS05565
gene id: 123214:PERMA_RS05565
uniprot id: C0QQF9
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

123214:PERMA RS04250
gene id: 123214:PERMA_RS04250
uniprot id: C0QPP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

123214:PERMA RS05975
gene id: 123214:PERMA_RS05975
uniprot id: C0QQN1
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

123214:PERMA RS08880
gene id: 123214:PERMA_RS08880
uniprot id: C0QSA6
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

123214:PERMA RS01795
gene id: 123214:PERMA_RS01795
uniprot id: C0QTY8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

123214:PERMA RS05575
gene id: 123214:PERMA_RS05575
uniprot id: C0QQG1
names: Similarity
messages: Belongs to the CarB family.

123214:PERMA RS03910
gene id: 123214:PERMA_RS03910
uniprot id: C0QPH7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

123214:PERMA RS03570
gene id: 123214:PERMA_RS03570
uniprot id: C0QPA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

123214:PERMA RS08275
gene id: 123214:PERMA_RS08275
uniprot id: C0QRY8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

123214:PERMA RS03420
gene id: 123214:PERMA_RS03420
uniprot id: C0QP78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

123214:PERMA RS05290
gene id: 123214:PERMA_RS05290
uniprot id: C0QQA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

123214:PERMA RS10600
gene id: 123214:PERMA_RS10600
uniprot id: C0QSL3
names: Similarity
messages: Belongs to the transglycosylase Slt family.

123214:PERMA RS01195
gene id: 123214:PERMA_RS01195
uniprot id: C0QTM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

123214:PERMA RS07040
gene id: 123214:PERMA_RS07040
uniprot id: C0QR92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

123214:PERMA RS03645
gene id: 123214:PERMA_RS03645
uniprot id: C0QPC4
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

123214:PERMA RS05485
gene id: 123214:PERMA_RS05485
uniprot id: C0QQE3
names: Similarity
messages: Belongs to the LacAB/RpiB family.

123214:PERMA RS04535
gene id: 123214:PERMA_RS04535
uniprot id: C0QPV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

123214:PERMA RS03145
gene id: 123214:PERMA_RS03145
uniprot id: C0QUQ5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

123214:PERMA RS04770
gene id: 123214:PERMA_RS04770
uniprot id: C0QPZ8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

123214:PERMA RS06265
gene id: 123214:PERMA_RS06265
uniprot id: C0QQU0
names: PTM
messages: Binds 1 heme c group covalently per subunit.

123214:PERMA RS06715
gene id: 123214:PERMA_RS06715
uniprot id: C0QR25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

123214:PERMA RS01330
gene id: 123214:PERMA_RS01330
uniprot id: C0QTQ0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell inner membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

123214:PERMA RS07865
gene id: 123214:PERMA_RS07865
uniprot id: C0QRQ6
names: Similarity
messages: Belongs to the P(II) protein family.

123214:PERMA RS00440
gene id: 123214:PERMA_RS00440
uniprot id: C0QT72
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS03655
gene id: 123214:PERMA_RS03655
uniprot id: C0QPC6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

123214:PERMA RS08515
gene id: 123214:PERMA_RS08515
uniprot id: C0QS35
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

123214:PERMA RS01030
gene id: 123214:PERMA_RS01030
uniprot id: C0QTJ0
names: Similarity
messages: Belongs to the GSP E family.

123214:PERMA RS01280
gene id: 123214:PERMA_RS01280
uniprot id: C0QTP0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

123214:PERMA RS07635
gene id: 123214:PERMA_RS07635
uniprot id: C0QRL1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

123214:PERMA RS08115
gene id: 123214:PERMA_RS08115
uniprot id: C0QRV6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

123214:PERMA RS07715
gene id: 123214:PERMA_RS07715
uniprot id: C0QRM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

123214:PERMA RS03030
gene id: 123214:PERMA_RS03030
uniprot id: C0QUN1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

123214:PERMA RS03740
gene id: 123214:PERMA_RS03740
uniprot id: C0QPE3
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

123214:PERMA RS07710
gene id: 123214:PERMA_RS07710
uniprot id: C0QRM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

123214:PERMA RS01810
gene id: 123214:PERMA_RS01810
uniprot id: C0QTZ1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

123214:PERMA RS06370
gene id: 123214:PERMA_RS06370
uniprot id: C0QQW1
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS06020
gene id: 123214:PERMA_RS06020
uniprot id: C0QQP0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

123214:PERMA RS02325
gene id: 123214:PERMA_RS02325
uniprot id: C0QU95
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

123214:PERMA RS01615
gene id: 123214:PERMA_RS01615
uniprot id: C0QTV3
names: Similarity
messages: Belongs to the DNA polymerase type-A family.

123214:PERMA RS03195
gene id: 123214:PERMA_RS03195
uniprot id: C0QUR5
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

123214:PERMA RS09495
gene id: 123214:PERMA_RS09495
uniprot id: C0QSM6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

123214:PERMA RS07335
gene id: 123214:PERMA_RS07335
uniprot id: C0QRF2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

123214:PERMA RS01540
gene id: 123214:PERMA_RS01540
uniprot id: C0QTT8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

123214:PERMA RS03640
gene id: 123214:PERMA_RS03640
uniprot id: C0QPC3
names: Similarity
names: Subunit
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

123214:PERMA RS04625
gene id: 123214:PERMA_RS04625
uniprot id: C0QPX0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

123214:PERMA RS01410
gene id: 123214:PERMA_RS01410
uniprot id: C0QTR3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS02620
gene id: 123214:PERMA_RS02620
uniprot id: C0QUE7
names: Similarity
messages: Belongs to the SAICAR synthetase family.

123214:PERMA RS09340
gene id: 123214:PERMA_RS09340
uniprot id: C0QSJ6
names: Similarity
messages: Belongs to the histone deacetylase family.

123214:PERMA RS03460
gene id: 123214:PERMA_RS03460
uniprot id: C0QP87
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

123214:PERMA RS01505
gene id: 123214:PERMA_RS01505
uniprot id: C0QTT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapD family.
messages: Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

123214:PERMA RS06000
gene id: 123214:PERMA_RS06000
uniprot id: C0QQN6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

123214:PERMA RS03520
gene id: 123214:PERMA_RS03520
uniprot id: C0QP99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliR/MopE/SpaR family.
messages: Membrane

123214:PERMA RS07565
gene id: 123214:PERMA_RS07565
uniprot id: C0QRJ7
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS05910
gene id: 123214:PERMA_RS05910
uniprot id: C0QQL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

123214:PERMA RS05185
gene id: 123214:PERMA_RS05185
uniprot id: C0QQ82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

123214:PERMA RS05915
gene id: 123214:PERMA_RS05915
uniprot id: C0QQL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

123214:PERMA RS00425
gene id: 123214:PERMA_RS00425
uniprot id: C0QT69
names: Similarity
messages: Belongs to the MotB family.

123214:PERMA RS03315
gene id: 123214:PERMA_RS03315
uniprot id: C0QP59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

123214:PERMA RS00900
gene id: 123214:PERMA_RS00900
uniprot id: C0QTG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

123214:PERMA RS09280
gene id: 123214:PERMA_RS09280
uniprot id: C0QSI4
names: Similarity
messages: Belongs to the VapB family.

123214:PERMA RS06560
gene id: 123214:PERMA_RS06560
uniprot id: C0QQZ6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

123214:PERMA RS06565
gene id: 123214:PERMA_RS06565
uniprot id: C0QQZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

123214:PERMA RS05225
gene id: 123214:PERMA_RS05225
uniprot id: C0QQ90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

123214:PERMA RS00250
gene id: 123214:PERMA_RS00250
uniprot id: C0QT34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

123214:PERMA RS01825
gene id: 123214:PERMA_RS01825
uniprot id: C0QTZ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

123214:PERMA RS07455
gene id: 123214:PERMA_RS07455
uniprot id: C0QRH8
names: Similarity
messages: Belongs to the GSP E family.

123214:PERMA RS04065
gene id: 123214:PERMA_RS04065
uniprot id: C0QPK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP K family.
messages: Cell inner membrane
messages: Membrane

123214:PERMA RS03065
gene id: 123214:PERMA_RS03065
uniprot id: C0QUN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

123214:PERMA RS09155
gene id: 123214:PERMA_RS09155
uniprot id: C0QSF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

123214:PERMA RS05885
gene id: 123214:PERMA_RS05885
uniprot id: C0QQL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

123214:PERMA RS06305
gene id: 123214:PERMA_RS06305
uniprot id: C0QQU8
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS00930
gene id: 123214:PERMA_RS00930
uniprot id: C0QTH0
names: Similarity
messages: Belongs to the peptidase S41A family.

123214:PERMA RS04810
gene id: 123214:PERMA_RS04810
uniprot id: C0QQ06
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

123214:PERMA RS06705
gene id: 123214:PERMA_RS06705
uniprot id: C0QR23
names: Similarity
messages: Belongs to the YicC/YloC family.

123214:PERMA RS06730
gene id: 123214:PERMA_RS06730
uniprot id: C0QR28
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

123214:PERMA RS03890
gene id: 123214:PERMA_RS03890
uniprot id: C0QPH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

123214:PERMA RS00910
gene id: 123214:PERMA_RS00910
uniprot id: C0QTG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

123214:PERMA RS06315
gene id: 123214:PERMA_RS06315
uniprot id: C0QQV0
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

123214:PERMA RS00030
gene id: 123214:PERMA_RS00030
uniprot id: C0QSZ0
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS02205
gene id: 123214:PERMA_RS02205
uniprot id: C0QU70
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS05240
gene id: 123214:PERMA_RS05240
uniprot id: C0QQ94
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

123214:PERMA RS00255
gene id: 123214:PERMA_RS00255
uniprot id: C0QT35
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

123214:PERMA RS04375
gene id: 123214:PERMA_RS04375
uniprot id: C0QPS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

123214:PERMA RS02155
gene id: 123214:PERMA_RS02155
uniprot id: C0QU59
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

123214:PERMA RS08470
gene id: 123214:PERMA_RS08470
uniprot id: C0QS26
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

123214:PERMA RS03135
gene id: 123214:PERMA_RS03135
uniprot id: C0QUQ3
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

123214:PERMA RS04790
gene id: 123214:PERMA_RS04790
uniprot id: C0QQ02
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.

123214:PERMA RS05925
gene id: 123214:PERMA_RS05925
uniprot id: C0QQK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

123214:PERMA RS08690
gene id: 123214:PERMA_RS08690
uniprot id: C0QS72
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

123214:PERMA RS01160
gene id: 123214:PERMA_RS01160
uniprot id: C0QTL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

123214:PERMA RS00170
gene id: 123214:PERMA_RS00170
uniprot id: C0QT18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

123214:PERMA RS04510
gene id: 123214:PERMA_RS04510
uniprot id: C0QPU7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

123214:PERMA RS02790
gene id: 123214:PERMA_RS02790
uniprot id: C0QUI3
names: Similarity
messages: Belongs to the AdoMet synthase family.

123214:PERMA RS08655
gene id: 123214:PERMA_RS08655
uniprot id: C0QS64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

123214:PERMA RS07985
gene id: 123214:PERMA_RS07985
uniprot id: C0QRT0
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

123214:PERMA RS08620
gene id: 123214:PERMA_RS08620
uniprot id: C0QS57
names: Similarity
messages: Belongs to the ClpA/ClpB family.

123214:PERMA RS06880
gene id: 123214:PERMA_RS06880
uniprot id: C0QR60
names: Similarity
messages: Belongs to the GARS family.

123214:PERMA RS08265
gene id: 123214:PERMA_RS08265
uniprot id: C0QRY6
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

123214:PERMA RS08020
gene id: 123214:PERMA_RS08020
uniprot id: C0QRT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

123214:PERMA RS01650
gene id: 123214:PERMA_RS01650
uniprot id: C0QTW1
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

123214:PERMA RS02465
gene id: 123214:PERMA_RS02465
uniprot id: C0QUB7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

123214:PERMA RS03110
gene id: 123214:PERMA_RS03110
uniprot id: C0QUP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

123214:PERMA RS10890
gene id: 123214:PERMA_RS10890
uniprot id: C0QSQ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

123214:PERMA RS02750
gene id: 123214:PERMA_RS02750
uniprot id: C0QUH3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

123214:PERMA RS00975
gene id: 123214:PERMA_RS00975
uniprot id: C0QTH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

123214:PERMA RS02860
gene id: 123214:PERMA_RS02860
uniprot id: C0QUJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

123214:PERMA RS02865
gene id: 123214:PERMA_RS02865
uniprot id: C0QUJ8
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

123214:PERMA RS04955
gene id: 123214:PERMA_RS04955
uniprot id: C0QQ35
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

123214:PERMA RS09175
gene id: 123214:PERMA_RS09175
uniprot id: C0QSG1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

123214:PERMA RS05930
gene id: 123214:PERMA_RS05930
uniprot id: C0QQM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

123214:PERMA RS00780
gene id: 123214:PERMA_RS00780
uniprot id: C0QTE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

123214:PERMA RS08390
gene id: 123214:PERMA_RS08390
uniprot id: C0QS10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

123214:PERMA RS02100
gene id: 123214:PERMA_RS02100
uniprot id: C0QU48
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

123214:PERMA RS09790
gene id: 123214:PERMA_RS09790
uniprot id: C0QSS9
names: Similarity
messages: Belongs to the GSP E family.

123214:PERMA RS08635
gene id: 123214:PERMA_RS08635
uniprot id: C0QS60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

123214:PERMA RS09800
gene id: 123214:PERMA_RS09800
uniprot id: C0QST1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

123214:PERMA RS01145
gene id: 123214:PERMA_RS01145
uniprot id: C0QTL4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS05315
gene id: 123214:PERMA_RS05315
uniprot id: C0QQA9
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

123214:PERMA RS00760
gene id: 123214:PERMA_RS00760
uniprot id: C0QTD6
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

123214:PERMA RS06430
gene id: 123214:PERMA_RS06430
uniprot id: C0QQX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Membrane

123214:PERMA RS03210
gene id: 123214:PERMA_RS03210
uniprot id: C0QUR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

123214:PERMA RS05270
gene id: 123214:PERMA_RS05270
uniprot id: C0QQA0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

123214:PERMA RS04870
gene id: 123214:PERMA_RS04870
uniprot id: C0QQ18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

123214:PERMA RS04120
gene id: 123214:PERMA_RS04120
uniprot id: C0QPL9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Monomer.

123214:PERMA RS07845
gene id: 123214:PERMA_RS07845
uniprot id: C0QRQ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Homodimer.
messages: Involved in the biosynthesis of 6-O-methylglucose lipopolysaccarides (MGLPs). Catalyzes the transfer of a glucose (Glc) moiety from uridine diphosphate (UDP-Glc) to the position 2 of 3-phospho-D-glycerate (3-PGA) to form glucosyl-3-phosphoglycerate (GPG). GpgS is most active with UDP-glucose, followed by GDP-glucose, ADP-glucose, and to a lesser extent, TDP-glucose. 3-PGA is the only acceptor for these glucosyl donors.
messages: Requires divalent cations for activity in the following order of efficiency: Mn(2+), Co(2+), Mg(2+) and Ni(2+) ions.

123214:PERMA RS07540
gene id: 123214:PERMA_RS07540
uniprot id: C0QRJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

123214:PERMA RS06300
gene id: 123214:PERMA_RS06300
uniprot id: C0QQU7
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS06710
gene id: 123214:PERMA_RS06710
uniprot id: C0QR24
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS04075
gene id: 123214:PERMA_RS04075
uniprot id: C0QPL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP M family.
messages: Cell inner membrane
messages: Membrane

123214:PERMA RS07255
gene id: 123214:PERMA_RS07255
uniprot id: C0QRD6
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

123214:PERMA RS03660
gene id: 123214:PERMA_RS03660
uniprot id: C0QPC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: FliG is one of 2 proteins (FliG, FliN) that might form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

123214:PERMA RS04775
gene id: 123214:PERMA_RS04775
uniprot id: C0QPZ9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS05075
gene id: 123214:PERMA_RS05075
uniprot id: C0QQ59
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS00510
gene id: 123214:PERMA_RS00510
uniprot id: C0QT86
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaved by autocatalysis into a large and a small subunit.
messages: This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.

123214:PERMA RS07330
gene id: 123214:PERMA_RS07330
uniprot id: C0QRF1
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

123214:PERMA RS05785
gene id: 123214:PERMA_RS05785
uniprot id: C0QQK1
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

123214:PERMA RS03505
gene id: 123214:PERMA_RS03505
uniprot id: C0QP96
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

123214:PERMA RS06425
gene id: 123214:PERMA_RS06425
uniprot id: C0QQX1
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

123214:PERMA RS02285
gene id: 123214:PERMA_RS02285
uniprot id: C0QU87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

123214:PERMA RS06105
gene id: 123214:PERMA_RS06105
uniprot id: C0QQQ7
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

123214:PERMA RS07345
gene id: 123214:PERMA_RS07345
uniprot id: C0QRF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

123214:PERMA RS01895
gene id: 123214:PERMA_RS01895
uniprot id: C0QU08
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane

123214:PERMA RS02275
gene id: 123214:PERMA_RS02275
uniprot id: C0QU85
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

123214:PERMA RS07630
gene id: 123214:PERMA_RS07630
uniprot id: C0QRL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

123214:PERMA RS00670
gene id: 123214:PERMA_RS00670
uniprot id: C0QTB8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

123214:PERMA RS01405
gene id: 123214:PERMA_RS01405
uniprot id: C0QTR2
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS01855
gene id: 123214:PERMA_RS01855
uniprot id: C0QU00
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS10485
gene id: 123214:PERMA_RS10485
uniprot id: C0QPG0
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS06365
gene id: 123214:PERMA_RS06365
uniprot id: C0QQW0
names: Similarity
messages: Belongs to the universal stress protein A family.

123214:PERMA RS00310
gene id: 123214:PERMA_RS00310
uniprot id: C0QT46
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

123214:PERMA RS05935
gene id: 123214:PERMA_RS05935
uniprot id: C0QQM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

123214:PERMA RS04295
gene id: 123214:PERMA_RS04295
uniprot id: C0QPQ4
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS06970
gene id: 123214:PERMA_RS06970
uniprot id: C0QR78
names: Similarity
messages: Belongs to the UPF0235 family.

123214:PERMA RS03470
gene id: 123214:PERMA_RS03470
uniprot id: C0QP89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

123214:PERMA RS09190
gene id: 123214:PERMA_RS09190
uniprot id: C0QSG4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

123214:PERMA RS05060
gene id: 123214:PERMA_RS05060
uniprot id: C0QQ56
names: Similarity
messages: Belongs to the HypE family.

123214:PERMA RS01140
gene id: 123214:PERMA_RS01140
uniprot id: C0QTL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

123214:PERMA RS05495
gene id: 123214:PERMA_RS05495
uniprot id: C0QQE5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS06440
gene id: 123214:PERMA_RS06440
uniprot id: C0QQX4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.

123214:PERMA RS04270
gene id: 123214:PERMA_RS04270
uniprot id: C0QPP9
names: Similarity
messages: Belongs to the CarB family.

123214:PERMA RS08150
gene id: 123214:PERMA_RS08150
uniprot id: C0QRW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

123214:PERMA RS00710
gene id: 123214:PERMA_RS00710
uniprot id: C0QTC6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

123214:PERMA RS06650
gene id: 123214:PERMA_RS06650
uniprot id: C0QR13
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

123214:PERMA RS02715
gene id: 123214:PERMA_RS02715
uniprot id: C0QUG6
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

123214:PERMA RS03415
gene id: 123214:PERMA_RS03415
uniprot id: C0QP77
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

123214:PERMA RS08100
gene id: 123214:PERMA_RS08100
uniprot id: C0QRV3
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

123214:PERMA RS04985
gene id: 123214:PERMA_RS04985
uniprot id: C0QQ41
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

123214:PERMA RS02280
gene id: 123214:PERMA_RS02280
uniprot id: C0QU86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

123214:PERMA RS05980
gene id: 123214:PERMA_RS05980
uniprot id: C0QQN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

123214:PERMA RS01950
gene id: 123214:PERMA_RS01950
uniprot id: C0QU19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

123214:PERMA RS04115
gene id: 123214:PERMA_RS04115
uniprot id: C0QPL8
names: Similarity
messages: Belongs to the rubredoxin family.

123214:PERMA RS02670
gene id: 123214:PERMA_RS02670
uniprot id: C0QUF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

123214:PERMA RS08270
gene id: 123214:PERMA_RS08270
uniprot id: C0QRY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

123214:PERMA RS00560
gene id: 123214:PERMA_RS00560
uniprot id: C0QT96
names: Similarity
messages: Belongs to the MEMO1 family.

123214:PERMA RS01315
gene id: 123214:PERMA_RS01315
uniprot id: C0QTP7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

123214:PERMA RS03155
gene id: 123214:PERMA_RS03155
uniprot id: C0QUQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

123214:PERMA RS08130
gene id: 123214:PERMA_RS08130
uniprot id: C0QRV9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

123214:PERMA RS02085
gene id: 123214:PERMA_RS02085
uniprot id: C0QU45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

123214:PERMA RS08460
gene id: 123214:PERMA_RS08460
uniprot id: C0QS24
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

123214:PERMA RS00350
gene id: 123214:PERMA_RS00350
uniprot id: C0QT54
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

123214:PERMA RS09570
gene id: 123214:PERMA_RS09570
uniprot id: C0QSP1
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

123214:PERMA RS02060
gene id: 123214:PERMA_RS02060
uniprot id: C0QU40
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS07545
gene id: 123214:PERMA_RS07545
uniprot id: C0QRJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

123214:PERMA RS04575
gene id: 123214:PERMA_RS04575
uniprot id: C0QPW0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

123214:PERMA RS07005
gene id: 123214:PERMA_RS07005
uniprot id: C0QR85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.
messages: In the N-terminal section; belongs to the complex I 30 kDa subunit family.
messages: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

123214:PERMA RS05940
gene id: 123214:PERMA_RS05940
uniprot id: C0QQM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

123214:PERMA RS02440
gene id: 123214:PERMA_RS02440
uniprot id: C0QUB2
names: Similarity
messages: Belongs to the creatininase superfamily.

123214:PERMA RS07155
gene id: 123214:PERMA_RS07155
uniprot id: C0QRB5
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

123214:PERMA RS02835
gene id: 123214:PERMA_RS02835
uniprot id: C0QUJ2
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

123214:PERMA RS04235
gene id: 123214:PERMA_RS04235
uniprot id: C0QPP2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

123214:PERMA RS08155
gene id: 123214:PERMA_RS08155
uniprot id: C0QRW4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

123214:PERMA RS04685
gene id: 123214:PERMA_RS04685
uniprot id: C0QPY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

123214:PERMA RS06890
gene id: 123214:PERMA_RS06890
uniprot id: C0QR62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

123214:PERMA RS03625
gene id: 123214:PERMA_RS03625
uniprot id: C0QPC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: Periplasm
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

123214:PERMA RS07360
gene id: 123214:PERMA_RS07360
uniprot id: C0QRF7
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS07025
gene id: 123214:PERMA_RS07025
uniprot id: C0QR89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

123214:PERMA RS04760
gene id: 123214:PERMA_RS04760
uniprot id: C0QPZ6
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

123214:PERMA RS00275
gene id: 123214:PERMA_RS00275
uniprot id: C0QT39
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

123214:PERMA RS07130
gene id: 123214:PERMA_RS07130
uniprot id: C0QRB0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS06150
gene id: 123214:PERMA_RS06150
uniprot id: C0QQR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

123214:PERMA RS06490
gene id: 123214:PERMA_RS06490
uniprot id: C0QQY4
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

123214:PERMA RS02940
gene id: 123214:PERMA_RS02940
uniprot id: C0QUL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

123214:PERMA RS09805
gene id: 123214:PERMA_RS09805
uniprot id: C0QST2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

123214:PERMA RS06545
gene id: 123214:PERMA_RS06545
uniprot id: C0QQZ3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS05960
gene id: 123214:PERMA_RS05960
uniprot id: C0QQM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

123214:PERMA RS06790
gene id: 123214:PERMA_RS06790
uniprot id: C0QR39
names: Similarity
messages: Belongs to the UPRTase family.

123214:PERMA RS03450
gene id: 123214:PERMA_RS03450
uniprot id: C0QP85
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

123214:PERMA RS03060
gene id: 123214:PERMA_RS03060
uniprot id: C0QUN8
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

123214:PERMA RS07035
gene id: 123214:PERMA_RS07035
uniprot id: C0QR91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

123214:PERMA RS06910
gene id: 123214:PERMA_RS06910
uniprot id: C0QR66
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS01925
gene id: 123214:PERMA_RS01925
uniprot id: C0QU13
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

123214:PERMA RS00025
gene id: 123214:PERMA_RS00025
uniprot id: C0QSY8
names: Similarity
messages: Belongs to the UbiD family.

123214:PERMA RS07530
gene id: 123214:PERMA_RS07530
uniprot id: C0QRJ0
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS00885
gene id: 123214:PERMA_RS00885
uniprot id: C0QTG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

123214:PERMA RS00365
gene id: 123214:PERMA_RS00365
uniprot id: C0QT57
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

123214:PERMA RS06920
gene id: 123214:PERMA_RS06920
uniprot id: C0QR68
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

123214:PERMA RS00335
gene id: 123214:PERMA_RS00335
uniprot id: C0QT51
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

123214:PERMA RS00380
gene id: 123214:PERMA_RS00380
uniprot id: C0QT60
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

123214:PERMA RS01035
gene id: 123214:PERMA_RS01035
uniprot id: C0QTJ1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

123214:PERMA RS05345
gene id: 123214:PERMA_RS05345
uniprot id: C0QQB5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS01300
gene id: 123214:PERMA_RS01300
uniprot id: C0QTP4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS07435
gene id: 123214:PERMA_RS07435
uniprot id: C0QRH3
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

123214:PERMA RS05410
gene id: 123214:PERMA_RS05410
uniprot id: C0QQC8
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS04615
gene id: 123214:PERMA_RS04615
uniprot id: C0QPW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

123214:PERMA RS02300
gene id: 123214:PERMA_RS02300
uniprot id: C0QU90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

123214:PERMA RS01455
gene id: 123214:PERMA_RS01455
uniprot id: C0QTS2
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS06345
gene id: 123214:PERMA_RS06345
uniprot id: C0QQV6
names: Cofactor
names: Similarity
messages: Belongs to the ApbE family.
messages: Magnesium. Can also use manganese.

123214:PERMA RS00745
gene id: 123214:PERMA_RS00745
uniprot id: C0QTD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

123214:PERMA RS02070
gene id: 123214:PERMA_RS02070
uniprot id: C0QU42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

123214:PERMA RS04420
gene id: 123214:PERMA_RS04420
uniprot id: C0QPS9
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

123214:PERMA RS05855
gene id: 123214:PERMA_RS05855
uniprot id: C0QQK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

123214:PERMA RS03545
gene id: 123214:PERMA_RS03545
uniprot id: C0QPA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

123214:PERMA RS08525
gene id: 123214:PERMA_RS08525
uniprot id: C0QS37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

123214:PERMA RS07445
gene id: 123214:PERMA_RS07445
uniprot id: C0QRH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

123214:PERMA RS03865
gene id: 123214:PERMA_RS03865
uniprot id: C0QPG8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

123214:PERMA RS09770
gene id: 123214:PERMA_RS09770
uniprot id: C0QSS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

123214:PERMA RS00405
gene id: 123214:PERMA_RS00405
uniprot id: C0QT65
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

123214:PERMA RS07015
gene id: 123214:PERMA_RS07015
uniprot id: C0QR87
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

123214:PERMA RS02785
gene id: 123214:PERMA_RS02785
uniprot id: C0QUI2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

123214:PERMA RS01150
gene id: 123214:PERMA_RS01150
uniprot id: C0QTL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

123214:PERMA RS07520
gene id: 123214:PERMA_RS07520
uniprot id: C0QRI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

123214:PERMA RS07805
gene id: 123214:PERMA_RS07805
uniprot id: C0QRP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

123214:PERMA RS07965
gene id: 123214:PERMA_RS07965
uniprot id: C0QRS6
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS03200
gene id: 123214:PERMA_RS03200
uniprot id: C0QUR6
names: Similarity
messages: Belongs to the glutamate synthase family.

123214:PERMA RS04085
gene id: 123214:PERMA_RS04085
uniprot id: C0QPL2
names: Similarity
messages: Belongs to the peptidase S8 family.

123214:PERMA RS07355
gene id: 123214:PERMA_RS07355
uniprot id: C0QRF6
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS01590
gene id: 123214:PERMA_RS01590
uniprot id: C0QTU8
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS05335
gene id: 123214:PERMA_RS05335
uniprot id: C0QQB3
names: Similarity
messages: Belongs to the UPF0047 family.

123214:PERMA RS00860
gene id: 123214:PERMA_RS00860
uniprot id: C0QTF6
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

123214:PERMA RS05470
gene id: 123214:PERMA_RS05470
uniprot id: C0QQE0
names: Similarity
messages: Belongs to the HepT RNase toxin family.

123214:PERMA RS01120
gene id: 123214:PERMA_RS01120
uniprot id: C0QTK9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

123214:PERMA RS06870
gene id: 123214:PERMA_RS06870
uniprot id: C0QR58
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

123214:PERMA RS01335
gene id: 123214:PERMA_RS01335
uniprot id: C0QTQ1
names: Similarity
messages: Belongs to the UPF0166 family.

123214:PERMA RS00045
gene id: 123214:PERMA_RS00045
uniprot id: C0QSZ3
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

123214:PERMA RS06115
gene id: 123214:PERMA_RS06115
uniprot id: C0QQQ9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

123214:PERMA RS09880
gene id: 123214:PERMA_RS09880
uniprot id: C0QSU6
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

123214:PERMA RS00480
gene id: 123214:PERMA_RS00480
uniprot id: C0QT80
names: Similarity
messages: Belongs to the CinA family.

123214:PERMA RS08290
gene id: 123214:PERMA_RS08290
uniprot id: C0QRZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

123214:PERMA RS02605
gene id: 123214:PERMA_RS02605
uniprot id: C0QUE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

123214:PERMA RS08725
gene id: 123214:PERMA_RS08725
uniprot id: C0QS79
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

123214:PERMA RS04500
gene id: 123214:PERMA_RS04500
uniprot id: C0QPU5
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homomer.

123214:PERMA RS01475
gene id: 123214:PERMA_RS01475
uniprot id: C0QTS6
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

123214:PERMA RS07440
gene id: 123214:PERMA_RS07440
uniprot id: C0QRH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm

123214:PERMA RS06855
gene id: 123214:PERMA_RS06855
uniprot id: C0QR54
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

123214:PERMA RS02775
gene id: 123214:PERMA_RS02775
uniprot id: C0QUI0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

123214:PERMA RS06905
gene id: 123214:PERMA_RS06905
uniprot id: C0QR65
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

123214:PERMA RS09565
gene id: 123214:PERMA_RS09565
uniprot id: C0QSP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

123214:PERMA RS04545
gene id: 123214:PERMA_RS04545
uniprot id: C0QPV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homodimer.

123214:PERMA RS01770
gene id: 123214:PERMA_RS01770
uniprot id: C0QTY3
names: Similarity
messages: Belongs to the thioredoxin family.

123214:PERMA RS04260
gene id: 123214:PERMA_RS04260
uniprot id: C0QPP7
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

123214:PERMA RS01420
gene id: 123214:PERMA_RS01420
uniprot id: C0QTR5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

123214:PERMA RS10065
gene id: 123214:PERMA_RS10065
uniprot id: C0QSY1
names: Similarity
messages: Belongs to the P(II) protein family.

123214:PERMA RS01695
gene id: 123214:PERMA_RS01695
uniprot id: C0QTX0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

123214:PERMA RS02225
gene id: 123214:PERMA_RS02225
uniprot id: C0QU74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

123214:PERMA RS03185
gene id: 123214:PERMA_RS03185
uniprot id: C0QUR3
names: Similarity
messages: Belongs to the peptidase S26 family.

123214:PERMA RS09765
gene id: 123214:PERMA_RS09765
uniprot id: C0QSS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

123214:PERMA RS00600
gene id: 123214:PERMA_RS00600
uniprot id: C0QTA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

123214:PERMA RS01100
gene id: 123214:PERMA_RS01100
uniprot id: C0QTK4
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

123214:PERMA RS05685
gene id: 123214:PERMA_RS05685
uniprot id: C0QQI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

123214:PERMA RS02725
gene id: 123214:PERMA_RS02725
uniprot id: C0QUG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

123214:PERMA RS03915
gene id: 123214:PERMA_RS03915
uniprot id: C0QPH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

123214:PERMA RS01675
gene id: 123214:PERMA_RS01675
uniprot id: C0QTW6
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

123214:PERMA RS01665
gene id: 123214:PERMA_RS01665
uniprot id: C0QTW4
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

123214:PERMA RS03180
gene id: 123214:PERMA_RS03180
uniprot id: C0QUR2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS07575
gene id: 123214:PERMA_RS07575
uniprot id: C0QRJ9
names: Similarity
messages: Belongs to the citrate synthase family.

123214:PERMA RS04875
gene id: 123214:PERMA_RS04875
uniprot id: C0QQ19
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS06640
gene id: 123214:PERMA_RS06640
uniprot id: C0QR11
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

123214:PERMA RS07870
gene id: 123214:PERMA_RS07870
uniprot id: C0QRQ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

123214:PERMA RS09380
gene id: 123214:PERMA_RS09380
uniprot id: C0QSK4
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

123214:PERMA RS06875
gene id: 123214:PERMA_RS06875
uniprot id: C0QR59
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

123214:PERMA RS06400
gene id: 123214:PERMA_RS06400
uniprot id: C0QQW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

123214:PERMA RS02675
gene id: 123214:PERMA_RS02675
uniprot id: C0QUF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

123214:PERMA RS04885
gene id: 123214:PERMA_RS04885
uniprot id: C0QQ21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

123214:PERMA RS07850
gene id: 123214:PERMA_RS07850
uniprot id: C0QRQ3
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

123214:PERMA RS09795
gene id: 123214:PERMA_RS09795
uniprot id: C0QST0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

123214:PERMA RS05970
gene id: 123214:PERMA_RS05970
uniprot id: C0QQN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

123214:PERMA RS06260
gene id: 123214:PERMA_RS06260
uniprot id: C0QQT9
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS03365
gene id: 123214:PERMA_RS03365
uniprot id: C0QP67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsL family.
messages: Cell membrane
messages: Essential cell division protein.
messages: Membrane

123214:PERMA RS01270
gene id: 123214:PERMA_RS01270
uniprot id: C0QTN8
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

123214:PERMA RS00820
gene id: 123214:PERMA_RS00820
uniprot id: C0QTE8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

123214:PERMA RS02975
gene id: 123214:PERMA_RS02975
uniprot id: C0QUM0
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS00950
gene id: 123214:PERMA_RS00950
uniprot id: C0QTH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

123214:PERMA RS01980
gene id: 123214:PERMA_RS01980
uniprot id: C0QU24
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

123214:PERMA RS01060
gene id: 123214:PERMA_RS01060
uniprot id: C0QTJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

123214:PERMA RS00320
gene id: 123214:PERMA_RS00320
uniprot id: C0QT48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

123214:PERMA RS00995
gene id: 123214:PERMA_RS00995
uniprot id: C0QTI2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL31 family.

123214:PERMA RS01045
gene id: 123214:PERMA_RS01045
uniprot id: C0QTJ3
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

123214:PERMA RS09935
gene id: 123214:PERMA_RS09935
uniprot id: C0QSV7
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS07625
gene id: 123214:PERMA_RS07625
uniprot id: C0QRK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

123214:PERMA RS01655
gene id: 123214:PERMA_RS01655
uniprot id: C0QTW2
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

123214:PERMA RS09680
gene id: 123214:PERMA_RS09680
uniprot id: C0QSQ7
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS07095
gene id: 123214:PERMA_RS07095
uniprot id: C0QRA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A probable RNA-binding protein.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm

123214:PERMA RS08560
gene id: 123214:PERMA_RS08560
uniprot id: C0QS44
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

123214:PERMA RS04785
gene id: 123214:PERMA_RS04785
uniprot id: C0QQ01
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

123214:PERMA RS05510
gene id: 123214:PERMA_RS05510
uniprot id: C0QQE8
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

123214:PERMA RS00945
gene id: 123214:PERMA_RS00945
uniprot id: C0QTH3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

123214:PERMA RS10840
gene id: 123214:PERMA_RS10840
uniprot id: C0QPA5
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

123214:PERMA RS09180
gene id: 123214:PERMA_RS09180
uniprot id: C0QSG2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

123214:PERMA RS04405
gene id: 123214:PERMA_RS04405
uniprot id: C0QPS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

123214:PERMA RS02560
gene id: 123214:PERMA_RS02560
uniprot id: C0QUD6
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS01765
gene id: 123214:PERMA_RS01765
uniprot id: C0QTY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

123214:PERMA RS09785
gene id: 123214:PERMA_RS09785
uniprot id: C0QSS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

123214:PERMA RS08235
gene id: 123214:PERMA_RS08235
uniprot id: C0QRY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

123214:PERMA RS00185
gene id: 123214:PERMA_RS00185
uniprot id: C0QT21
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

123214:PERMA RS07780
gene id: 123214:PERMA_RS07780
uniprot id: C0QRN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

123214:PERMA RS09845
gene id: 123214:PERMA_RS09845
uniprot id: C0QST9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

123214:PERMA RS00755
gene id: 123214:PERMA_RS00755
uniprot id: C0QTD5
names: Similarity
messages: Belongs to the MoaD family.

123214:PERMA RS01870
gene id: 123214:PERMA_RS01870
uniprot id: C0QU03
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

123214:PERMA RS06590
gene id: 123214:PERMA_RS06590
uniprot id: C0QR02
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

123214:PERMA RS03795
gene id: 123214:PERMA_RS03795
uniprot id: C0QPF4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

123214:PERMA RS02150
gene id: 123214:PERMA_RS02150
uniprot id: C0QU58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

123214:PERMA RS01800
gene id: 123214:PERMA_RS01800
uniprot id: C0QTY9
names: Similarity
messages: Belongs to the UPF0102 family.

123214:PERMA RS00080
gene id: 123214:PERMA_RS00080
uniprot id: C0QT00
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

123214:PERMA RS08420
gene id: 123214:PERMA_RS08420
uniprot id: C0QS16
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

123214:PERMA RS09480
gene id: 123214:PERMA_RS09480
uniprot id: C0QSM3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

123214:PERMA RS03805
gene id: 123214:PERMA_RS03805
uniprot id: C0QPF6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

123214:PERMA RS04525
gene id: 123214:PERMA_RS04525
uniprot id: C0QPV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

123214:PERMA RS00305
gene id: 123214:PERMA_RS00305
uniprot id: C0QT45
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

123214:PERMA RS08225
gene id: 123214:PERMA_RS08225
uniprot id: C0QRX8
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

123214:PERMA RS07890
gene id: 123214:PERMA_RS07890
uniprot id: C0QRR1
names: Similarity
messages: Belongs to the LOG family.

123214:PERMA RS06410
gene id: 123214:PERMA_RS06410
uniprot id: C0QQW8
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS07490
gene id: 123214:PERMA_RS07490
uniprot id: C0QRI3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

123214:PERMA RS04570
gene id: 123214:PERMA_RS04570
uniprot id: C0QPV9
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

123214:PERMA RS02525
gene id: 123214:PERMA_RS02525
uniprot id: C0QUC9
names: Similarity
messages: Belongs to the universal stress protein A family.

123214:PERMA RS02970
gene id: 123214:PERMA_RS02970
uniprot id: C0QUL9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

123214:PERMA RS10935
gene id: 123214:PERMA_RS10935
uniprot id: C0QSN6
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

123214:PERMA RS07365
gene id: 123214:PERMA_RS07365
uniprot id: C0QRF8
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

123214:PERMA RS03370
gene id: 123214:PERMA_RS03370
uniprot id: C0QP68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

123214:PERMA RS05395
gene id: 123214:PERMA_RS05395
uniprot id: C0QQC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

123214:PERMA RS02615
gene id: 123214:PERMA_RS02615
uniprot id: C0QUE6
names: Similarity
messages: Belongs to the UDPGP type 2 family.

123214:PERMA RS09260
gene id: 123214:PERMA_RS09260
uniprot id: C0QSI0
names: Similarity
messages: Belongs to the UPF0175 family.

123214:PERMA RS01265
gene id: 123214:PERMA_RS01265
uniprot id: C0QTN7
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

123214:PERMA RS09385
gene id: 123214:PERMA_RS09385
uniprot id: C0QSK5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SoxA family.
messages: Binds 2 heme groups per subunit.
messages: Heterodimer of SoxA and SoxX.
messages: Periplasm

123214:PERMA RS00035
gene id: 123214:PERMA_RS00035
uniprot id: C0QSZ1
names: Similarity
messages: Belongs to the peptidase S16 family.

123214:PERMA RS06390
gene id: 123214:PERMA_RS06390
uniprot id: C0QQW4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

123214:PERMA RS03025
gene id: 123214:PERMA_RS03025
uniprot id: C0QUN0
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

123214:PERMA RS06415
gene id: 123214:PERMA_RS06415
uniprot id: C0QQW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

123214:PERMA RS01995
gene id: 123214:PERMA_RS01995
uniprot id: C0QU27
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

123214:PERMA RS08630
gene id: 123214:PERMA_RS08630
uniprot id: C0QS59
names: Similarity
messages: Belongs to the Skp family.

123214:PERMA RS07900
gene id: 123214:PERMA_RS07900
uniprot id: C0QRR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

123214:PERMA RS06575
gene id: 123214:PERMA_RS06575
uniprot id: C0QQZ9
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

123214:PERMA RS04940
gene id: 123214:PERMA_RS04940
uniprot id: C0QQ32
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

123214:PERMA RS03670
gene id: 123214:PERMA_RS03670
uniprot id: C0QPC9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

123214:PERMA RS01990
gene id: 123214:PERMA_RS01990
uniprot id: C0QU26
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

123214:PERMA RS06140
gene id: 123214:PERMA_RS06140
uniprot id: C0QQR5
names: Caution
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS09945
gene id: 123214:PERMA_RS09945
uniprot id: C0QSV9
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS00010
gene id: 123214:PERMA_RS00010
uniprot id: C0QSY5
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

123214:PERMA RS04245
gene id: 123214:PERMA_RS04245
uniprot id: C0QPP4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

123214:PERMA RS05625
gene id: 123214:PERMA_RS05625
uniprot id: C0QQH1
names: Similarity
messages: Belongs to the class-I fumarase family.

123214:PERMA RS05100
gene id: 123214:PERMA_RS05100
uniprot id: C0QQ64
names: Subcellular Location Annotation
messages: Cytoplasm

123214:PERMA RS00985
gene id: 123214:PERMA_RS00985
uniprot id: C0QTI0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

123214:PERMA RS09535
gene id: 123214:PERMA_RS09535
uniprot id: C0QSN4
names: Similarity
messages: Belongs to the ModE family.

123214:PERMA RS01965
gene id: 123214:PERMA_RS01965
uniprot id: C0QU22
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

123214:PERMA RS00520
gene id: 123214:PERMA_RS00520
uniprot id: C0QT88
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS02140
gene id: 123214:PERMA_RS02140
uniprot id: C0QU56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

123214:PERMA RS01935
gene id: 123214:PERMA_RS01935
uniprot id: C0QU15
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

123214:PERMA RS05405
gene id: 123214:PERMA_RS05405
uniprot id: C0QQC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

123214:PERMA RS00295
gene id: 123214:PERMA_RS00295
uniprot id: C0QT43
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

123214:PERMA RS07430
gene id: 123214:PERMA_RS07430
uniprot id: C0QRH2
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

123214:PERMA RS08530
gene id: 123214:PERMA_RS08530
uniprot id: C0QS38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell inner membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

123214:PERMA RS06010
gene id: 123214:PERMA_RS06010
uniprot id: C0QQN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

123214:PERMA RS05620
gene id: 123214:PERMA_RS05620
uniprot id: C0QQH0
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

123214:PERMA RS03095
gene id: 123214:PERMA_RS03095
uniprot id: C0QUP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

123214:PERMA RS02700
gene id: 123214:PERMA_RS02700
uniprot id: C0QUG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

123214:PERMA RS01070
gene id: 123214:PERMA_RS01070
uniprot id: C0QTJ8
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

123214:PERMA RS00895
gene id: 123214:PERMA_RS00895
uniprot id: C0QTG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

123214:PERMA RS04370
gene id: 123214:PERMA_RS04370
uniprot id: C0QPR9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

123214:PERMA RS03555
gene id: 123214:PERMA_RS03555
uniprot id: C0QPA6
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

123214:PERMA RS03400
gene id: 123214:PERMA_RS03400
uniprot id: C0QP74
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

123214:PERMA RS00530
gene id: 123214:PERMA_RS00530
uniprot id: C0QT90
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

123214:PERMA RS02680
gene id: 123214:PERMA_RS02680
uniprot id: C0QUF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

123214:PERMA RS05750
gene id: 123214:PERMA_RS05750
uniprot id: C0QQJ4
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

123214:PERMA RS08105
gene id: 123214:PERMA_RS08105
uniprot id: C0QRV4
names: Similarity
messages: Belongs to the aspartokinase family.

123214:PERMA RS08425
gene id: 123214:PERMA_RS08425
uniprot id: C0QS17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

123214:PERMA RS05955
gene id: 123214:PERMA_RS05955
uniprot id: C0QQM7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

123214:PERMA RS09555
gene id: 123214:PERMA_RS09555
uniprot id: C0QSN8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

123214:PERMA RS04430
gene id: 123214:PERMA_RS04430
uniprot id: C0QPT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

123214:PERMA RS02900
gene id: 123214:PERMA_RS02900
uniprot id: C0QUK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

123214:PERMA RS06955
gene id: 123214:PERMA_RS06955
uniprot id: C0QR75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

123214:PERMA RS04030
gene id: 123214:PERMA_RS04030
uniprot id: C0QPK1
names: Subcellular Location Annotation
messages: Membrane

123214:PERMA RS10495
gene id: 123214:PERMA_RS10495
uniprot id: C0QPL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family. GSP D subfamily.
messages: Cell outer membrane

123214:PERMA RS04050
gene id: 123214:PERMA_RS04050
uniprot id: C0QPK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

123214:PERMA RS03995
gene id: 123214:PERMA_RS03995
uniprot id: C0QPJ4
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

123214:PERMA RS01235
gene id: 123214:PERMA_RS01235
uniprot id: C0QTN2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

123214:PERMA RS03900
gene id: 123214:PERMA_RS03900
uniprot id: C0QPH5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

123214:PERMA RS01115
gene id: 123214:PERMA_RS01115
uniprot id: C0QTK8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

123214:PERMA RS05340
gene id: 123214:PERMA_RS05340
uniprot id: C0QQB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

123214:PERMA RS04675
gene id: 123214:PERMA_RS04675
uniprot id: C0QPY0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

123214:PERMA RS07380
gene id: 123214:PERMA_RS07380
uniprot id: C0QRG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

123214:PERMA RS06040
gene id: 123214:PERMA_RS06040
uniprot id: C0QQP4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

123214:PERMA RS01135
gene id: 123214:PERMA_RS01135
uniprot id: C0QTL2
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

123214:PERMA RS09160
gene id: 123214:PERMA_RS09160
uniprot id: C0QSF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

123214:PERMA RS01970
gene id: 123214:PERMA_RS01970
uniprot id: C0QU23
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

123214:PERMA RS02850
gene id: 123214:PERMA_RS02850
uniprot id: C0QUJ5
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

123214:PERMA RS07925
gene id: 123214:PERMA_RS07925
uniprot id: C0QRR8
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

123214:PERMA RS08760
gene id: 123214:PERMA_RS08760
uniprot id: C0QS86
names: Similarity
messages: Belongs to the hemerythrin family.

123214:PERMA RS00660
gene id: 123214:PERMA_RS00660
uniprot id: C0QTB6
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

123214:PERMA RS01875
gene id: 123214:PERMA_RS01875
uniprot id: C0QU04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane