1224164:B843 RS09280
gene id: 1224164:B843_RS09280
uniprot id: W5Y9L6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

1224164:B843 RS08725
gene id: 1224164:B843_RS08725
uniprot id: W5Y1N3
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

1224164:B843 RS00215
gene id: 1224164:B843_RS00215
uniprot id: W5Y4N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

1224164:B843 RS09015
gene id: 1224164:B843_RS09015
uniprot id: W5Y2R1
names: Similarity
messages: Belongs to the YggT family.

1224164:B843 RS09610
gene id: 1224164:B843_RS09610
uniprot id: W5Y1X4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1224164:B843 RS12130
gene id: 1224164:B843_RS12130
uniprot id: W5YB48
names: Similarity
messages: Belongs to the peptidase M1 family.

1224164:B843 RS05765
gene id: 1224164:B843_RS05765
uniprot id: W5Y0X1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1224164:B843 RS01155
gene id: 1224164:B843_RS01155
uniprot id: W5XY59
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1224164:B843 RS09760
gene id: 1224164:B843_RS09760
uniprot id: W5Y210
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224164:B843 RS02000
gene id: 1224164:B843_RS02000
uniprot id: W5XXV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS08900
gene id: 1224164:B843_RS08900
uniprot id: W5Y1R3
names: Similarity
messages: Belongs to the HSP15 family.

1224164:B843 RS09800
gene id: 1224164:B843_RS09800
uniprot id: W5Y339
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1224164:B843 RS00195
gene id: 1224164:B843_RS00195
uniprot id: W5XXN5
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS07465
gene id: 1224164:B843_RS07465
uniprot id: W5Y8S8
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1224164:B843 RS07595
gene id: 1224164:B843_RS07595
uniprot id: W5Y1V9
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1224164:B843 RS07005
gene id: 1224164:B843_RS07005
uniprot id: W5Y0N0
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS08150
gene id: 1224164:B843_RS08150
uniprot id: W5Y1C7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS07660
gene id: 1224164:B843_RS07660
uniprot id: W5Y142
names: Similarity
messages: Belongs to the peptidase A24 family.

1224164:B843 RS12730
gene id: 1224164:B843_RS12730
uniprot id: W5Y4T1
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

1224164:B843 RS00010
gene id: 1224164:B843_RS00010
uniprot id: W5Y4K5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1224164:B843 RS08095
gene id: 1224164:B843_RS08095
uniprot id: W5Y175
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

1224164:B843 RS01195
gene id: 1224164:B843_RS01195
uniprot id: W5Y548
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1224164:B843 RS08500
gene id: 1224164:B843_RS08500
uniprot id: W5Y1J7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS10465
gene id: 1224164:B843_RS10465
uniprot id: W5Y3J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

1224164:B843 RS04995
gene id: 1224164:B843_RS04995
uniprot id: W5XZP9
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1224164:B843 RS10935
gene id: 1224164:B843_RS10935
uniprot id: W5Y2R6
names: Similarity
messages: Belongs to the PstS family.

1224164:B843 RS09090
gene id: 1224164:B843_RS09090
uniprot id: W5Y2S7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1224164:B843 RS09210
gene id: 1224164:B843_RS09210
uniprot id: W5Y2R7
names: Similarity
messages: Belongs to the asparagine synthetase family.

1224164:B843 RS08945
gene id: 1224164:B843_RS08945
uniprot id: W5Y1M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

1224164:B843 RS08250
gene id: 1224164:B843_RS08250
uniprot id: W5Y1E5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

1224164:B843 RS14030
gene id: 1224164:B843_RS14030
uniprot id: W5Y3N6
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS07540
gene id: 1224164:B843_RS07540
uniprot id: W5Y8U2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS06305
gene id: 1224164:B843_RS06305
uniprot id: W5Y172
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1224164:B843 RS10575
gene id: 1224164:B843_RS10575
uniprot id: W5Y3K9
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

1224164:B843 RS07640
gene id: 1224164:B843_RS07640
uniprot id: W5Y8V7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1224164:B843 RS11860
gene id: 1224164:B843_RS11860
uniprot id: W5Y4D5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1224164:B843 RS09635
gene id: 1224164:B843_RS09635
uniprot id: W5Y1X9
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS11445
gene id: 1224164:B843_RS11445
uniprot id: W5Y407
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS08135
gene id: 1224164:B843_RS08135
uniprot id: W5Y251
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1224164:B843 RS12950
gene id: 1224164:B843_RS12950
uniprot id: W5Y522
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS02875
gene id: 1224164:B843_RS02875
uniprot id: W5Y647
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1224164:B843 RS06630
gene id: 1224164:B843_RS06630
uniprot id: W5Y0C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

1224164:B843 RS06475
gene id: 1224164:B843_RS06475
uniprot id: W5Y828
names: Similarity
messages: Belongs to the universal stress protein A family.

1224164:B843 RS06740
gene id: 1224164:B843_RS06740
uniprot id: W5Y1F9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1224164:B843 RS07420
gene id: 1224164:B843_RS07420
uniprot id: W5Y1R9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

1224164:B843 RS01405
gene id: 1224164:B843_RS01405
uniprot id: W5XXC4
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1224164:B843 RS02445
gene id: 1224164:B843_RS02445
uniprot id: W5XY81
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1224164:B843 RS00490
gene id: 1224164:B843_RS00490
uniprot id: W5XX17
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS04390
gene id: 1224164:B843_RS04390
uniprot id: W5Y042
names: Similarity
messages: Belongs to the FPG family.

1224164:B843 RS02615
gene id: 1224164:B843_RS02615
uniprot id: W5XY34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1224164:B843 RS06055
gene id: 1224164:B843_RS06055
uniprot id: W5Y7W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS12495
gene id: 1224164:B843_RS12495
uniprot id: W5Y3N9
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

1224164:B843 RS05535
gene id: 1224164:B843_RS05535
uniprot id: W5Y0P4
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

1224164:B843 RS07095
gene id: 1224164:B843_RS07095
uniprot id: W5Y1M7
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.

1224164:B843 RS05865
gene id: 1224164:B843_RS05865
uniprot id: W5Y0Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1224164:B843 RS02730
gene id: 1224164:B843_RS02730
uniprot id: W5XZ19
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS07485
gene id: 1224164:B843_RS07485
uniprot id: W5Y107
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS10130
gene id: 1224164:B843_RS10130
uniprot id: W5Y2C6
names: Similarity
messages: Belongs to the peptidase M1 family.

1224164:B843 RS12425
gene id: 1224164:B843_RS12425
uniprot id: W5YBB6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.

1224164:B843 RS06500
gene id: 1224164:B843_RS06500
uniprot id: W5Y833
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1224164:B843 RS06125
gene id: 1224164:B843_RS06125
uniprot id: W5Y076
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1224164:B843 RS03105
gene id: 1224164:B843_RS03105
uniprot id: W5XZ90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpqB lipoprotein family.
messages: Cell membrane

1224164:B843 RS04560
gene id: 1224164:B843_RS04560
uniprot id: W5Y031
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1224164:B843 RS01520
gene id: 1224164:B843_RS01520
uniprot id: W5XYB5
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

1224164:B843 RS10035
gene id: 1224164:B843_RS10035
uniprot id: W5Y2G2
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1224164:B843 RS04785
gene id: 1224164:B843_RS04785
uniprot id: W5Y075
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1224164:B843 RS06020
gene id: 1224164:B843_RS06020
uniprot id: W5Y029
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1224164:B843 RS10795
gene id: 1224164:B843_RS10795
uniprot id: W5YAF8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS07240
gene id: 1224164:B843_RS07240
uniprot id: W5Y8K4
names: Subunit
messages: Heterodimer of an alpha and a beta chain.

1224164:B843 RS04140
gene id: 1224164:B843_RS04140
uniprot id: W5XZT0
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

1224164:B843 RS07600
gene id: 1224164:B843_RS07600
uniprot id: W5Y201
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

1224164:B843 RS09810
gene id: 1224164:B843_RS09810
uniprot id: W5Y221
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS02685
gene id: 1224164:B843_RS02685
uniprot id: W5XZ58
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1224164:B843 RS07555
gene id: 1224164:B843_RS07555
uniprot id: W5Y0Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1224164:B843 RS12140
gene id: 1224164:B843_RS12140
uniprot id: W5Y4J0
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS11885
gene id: 1224164:B843_RS11885
uniprot id: W5Y4E1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1224164:B843 RS09590
gene id: 1224164:B843_RS09590
uniprot id: W5Y244
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

1224164:B843 RS08555
gene id: 1224164:B843_RS08555
uniprot id: W5Y979
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1224164:B843 RS11495
gene id: 1224164:B843_RS11495
uniprot id: W5Y417
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1224164:B843 RS02190
gene id: 1224164:B843_RS02190
uniprot id: W5XXR3
names: Similarity
messages: Belongs to the heat shock protein 70 family.

1224164:B843 RS11100
gene id: 1224164:B843_RS11100
uniprot id: W5YAK6
names: Similarity
messages: Belongs to the GARS family.

1224164:B843 RS05045
gene id: 1224164:B843_RS05045
uniprot id: W5XZQ9
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS05705
gene id: 1224164:B843_RS05705
uniprot id: W5Y0S5
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS12925
gene id: 1224164:B843_RS12925
uniprot id: W5Y519
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS02205
gene id: 1224164:B843_RS02205
uniprot id: W5XYR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1224164:B843 RS10705
gene id: 1224164:B843_RS10705
uniprot id: W5Y3N0
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

1224164:B843 RS07480
gene id: 1224164:B843_RS07480
uniprot id: W5Y0X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

1224164:B843 RS00460
gene id: 1224164:B843_RS00460
uniprot id: W5XWU6
names: Similarity
messages: Belongs to the RutC family.

1224164:B843 RS04360
gene id: 1224164:B843_RS04360
uniprot id: W5XZY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1224164:B843 RS04555
gene id: 1224164:B843_RS04555
uniprot id: W5Y713
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

1224164:B843 RS06460
gene id: 1224164:B843_RS06460
uniprot id: W5Y1A6
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS11835
gene id: 1224164:B843_RS11835
uniprot id: W5Y4D2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1224164:B843 RS10690
gene id: 1224164:B843_RS10690
uniprot id: W5Y2M5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.
messages: Iron-storage protein.

1224164:B843 RS10325
gene id: 1224164:B843_RS10325
uniprot id: W5Y3L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

1224164:B843 RS02625
gene id: 1224164:B843_RS02625
uniprot id: W5Y611
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1224164:B843 RS04750
gene id: 1224164:B843_RS04750
uniprot id: W5XZG0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the malate synthase family. GlcB subfamily.
messages: Cytoplasm
messages: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1224164:B843 RS12295
gene id: 1224164:B843_RS12295
uniprot id: W5Y3J1
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

1224164:B843 RS03115
gene id: 1224164:B843_RS03115
uniprot id: W5XYC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

1224164:B843 RS06465
gene id: 1224164:B843_RS06465
uniprot id: W5Y096
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1224164:B843 RS09245
gene id: 1224164:B843_RS09245
uniprot id: W5Y1R8
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1224164:B843 RS02135
gene id: 1224164:B843_RS02135
uniprot id: W5XYR5
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS10620
gene id: 1224164:B843_RS10620
uniprot id: W5Y2Q8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1224164:B843 RS09970
gene id: 1224164:B843_RS09970
uniprot id: W5Y3B2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1224164:B843 RS06905
gene id: 1224164:B843_RS06905
uniprot id: W5Y0K8
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS07460
gene id: 1224164:B843_RS07460
uniprot id: W5Y102
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1224164:B843 RS08810
gene id: 1224164:B843_RS08810
uniprot id: W5Y9C5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

1224164:B843 RS09770
gene id: 1224164:B843_RS09770
uniprot id: W5Y9V9
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

1224164:B843 RS10675
gene id: 1224164:B843_RS10675
uniprot id: W5YAD9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1224164:B843 RS14185
gene id: 1224164:B843_RS14185
uniprot id: W5Y7X0
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS08825
gene id: 1224164:B843_RS08825
uniprot id: W5Y1K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1224164:B843 RS08275
gene id: 1224164:B843_RS08275
uniprot id: W5Y1E9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1224164:B843 RS02140
gene id: 1224164:B843_RS02140
uniprot id: W5XXQ0
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS07230
gene id: 1224164:B843_RS07230
uniprot id: W5Y0N7
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

1224164:B843 RS02200
gene id: 1224164:B843_RS02200
uniprot id: W5Y5Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS02960
gene id: 1224164:B843_RS02960
uniprot id: W5XZB2
names: Similarity
messages: Belongs to the AccD/PCCB family.

1224164:B843 RS07685
gene id: 1224164:B843_RS07685
uniprot id: W5Y146
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

1224164:B843 RS08335
gene id: 1224164:B843_RS08335
uniprot id: W5Y284
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1224164:B843 RS07125
gene id: 1224164:B843_RS07125
uniprot id: W5Y0L6
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

1224164:B843 RS12640
gene id: 1224164:B843_RS12640
uniprot id: W5Y3R6
names: Similarity
messages: Belongs to the thioredoxin family.

1224164:B843 RS10610
gene id: 1224164:B843_RS10610
uniprot id: W5Y3Q0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1224164:B843 RS06385
gene id: 1224164:B843_RS06385
uniprot id: W5Y084
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS07825
gene id: 1224164:B843_RS07825
uniprot id: W5Y1Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1224164:B843 RS04610
gene id: 1224164:B843_RS04610
uniprot id: W5Y043
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1224164:B843 RS11960
gene id: 1224164:B843_RS11960
uniprot id: W5Y4F4
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

1224164:B843 RS04545
gene id: 1224164:B843_RS04545
uniprot id: W5XZ56
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1224164:B843 RS02405
gene id: 1224164:B843_RS02405
uniprot id: W5XYW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1224164:B843 RS03070
gene id: 1224164:B843_RS03070
uniprot id: W5XYJ3
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

1224164:B843 RS02935
gene id: 1224164:B843_RS02935
uniprot id: W5XZA7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1224164:B843 RS04510
gene id: 1224164:B843_RS04510
uniprot id: W5Y020
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

1224164:B843 RS02400
gene id: 1224164:B843_RS02400
uniprot id: W5Y5X2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1224164:B843 RS02420
gene id: 1224164:B843_RS02420
uniprot id: W5XY75
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1224164:B843 RS10315
gene id: 1224164:B843_RS10315
uniprot id: W5Y2F8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1224164:B843 RS01905
gene id: 1224164:B843_RS01905
uniprot id: W5Y5J3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS02580
gene id: 1224164:B843_RS02580
uniprot id: W5XYZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.

1224164:B843 RS11720
gene id: 1224164:B843_RS11720
uniprot id: W5Y380
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS08030
gene id: 1224164:B843_RS08030
uniprot id: W5Y903
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1224164:B843 RS08435
gene id: 1224164:B843_RS08435
uniprot id: W5Y2A2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1224164:B843 RS04195
gene id: 1224164:B843_RS04195
uniprot id: W5Y000
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1224164:B843 RS04625
gene id: 1224164:B843_RS04625
uniprot id: W5XZD6
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS02710
gene id: 1224164:B843_RS02710
uniprot id: W5XZ62
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutC family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

1224164:B843 RS11135
gene id: 1224164:B843_RS11135
uniprot id: W5Y3Y6
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS09735
gene id: 1224164:B843_RS09735
uniprot id: W5Y203
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1224164:B843 RS11410
gene id: 1224164:B843_RS11410
uniprot id: W5Y326
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

1224164:B843 RS08985
gene id: 1224164:B843_RS08985
uniprot id: W5Y2K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

1224164:B843 RS12645
gene id: 1224164:B843_RS12645
uniprot id: W5Y3U2
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS08110
gene id: 1224164:B843_RS08110
uniprot id: W5Y248
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1224164:B843 RS11045
gene id: 1224164:B843_RS11045
uniprot id: W5Y2W8
names: Similarity
messages: Belongs to the class-I fumarase family.

1224164:B843 RS09370
gene id: 1224164:B843_RS09370
uniprot id: W5Y1Z8
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

1224164:B843 RS08070
gene id: 1224164:B843_RS08070
uniprot id: W5Y170
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1224164:B843 RS02605
gene id: 1224164:B843_RS02605
uniprot id: W5XYZ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1224164:B843 RS01140
gene id: 1224164:B843_RS01140
uniprot id: W5XXD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1224164:B843 RS09795
gene id: 1224164:B843_RS09795
uniprot id: W5Y9W4
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

1224164:B843 RS10650
gene id: 1224164:B843_RS10650
uniprot id: W5YAD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

1224164:B843 RS08910
gene id: 1224164:B843_RS08910
uniprot id: W5Y2J3
names: Similarity
messages: Belongs to the IMPACT family.

1224164:B843 RS03190
gene id: 1224164:B843_RS03190
uniprot id: W5XYE0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1224164:B843 RS08085
gene id: 1224164:B843_RS08085
uniprot id: W5Y245
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

1224164:B843 RS04040
gene id: 1224164:B843_RS04040
uniprot id: W5Y6Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

1224164:B843 RS06300
gene id: 1224164:B843_RS06300
uniprot id: W5Y124
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1224164:B843 RS12280
gene id: 1224164:B843_RS12280
uniprot id: W5Y4G5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

1224164:B843 RS03120
gene id: 1224164:B843_RS03120
uniprot id: W5XYK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1224164:B843 RS01965
gene id: 1224164:B843_RS01965
uniprot id: W5XYN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

1224164:B843 RS11565
gene id: 1224164:B843_RS11565
uniprot id: W5YAV3
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

1224164:B843 RS07105
gene id: 1224164:B843_RS07105
uniprot id: W5Y0Q0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

1224164:B843 RS01605
gene id: 1224164:B843_RS01605
uniprot id: W5XXL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1224164:B843 RS05365
gene id: 1224164:B843_RS05365
uniprot id: W5XZQ2
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

1224164:B843 RS08545
gene id: 1224164:B843_RS08545
uniprot id: W5Y1F7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1224164:B843 RS02475
gene id: 1224164:B843_RS02475
uniprot id: W5Y5Y4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1224164:B843 RS06800
gene id: 1224164:B843_RS06800
uniprot id: W5Y0I7
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1224164:B843 RS02715
gene id: 1224164:B843_RS02715
uniprot id: W5XY51
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutB family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

1224164:B843 RS02455
gene id: 1224164:B843_RS02455
uniprot id: W5XYX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1224164:B843 RS06665
gene id: 1224164:B843_RS06665
uniprot id: W5Y874
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1224164:B843 RS13835
gene id: 1224164:B843_RS13835
uniprot id: W5Y1W0
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS11530
gene id: 1224164:B843_RS11530
uniprot id: W5Y327
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1224164:B843 RS08425
gene id: 1224164:B843_RS08425
uniprot id: W5Y1I2
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1224164:B843 RS02460
gene id: 1224164:B843_RS02460
uniprot id: W5XZ14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1224164:B843 RS06015
gene id: 1224164:B843_RS06015
uniprot id: W5Y116
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS11695
gene id: 1224164:B843_RS11695
uniprot id: W5Y377
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS02320
gene id: 1224164:B843_RS02320
uniprot id: W5XY21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1224164:B843 RS01185
gene id: 1224164:B843_RS01185
uniprot id: W5XX83
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS06490
gene id: 1224164:B843_RS06490
uniprot id: W5Y0A1
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS03175
gene id: 1224164:B843_RS03175
uniprot id: W5Y694
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1224164:B843 RS13095
gene id: 1224164:B843_RS13095
uniprot id: W5Y502
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1224164:B843 RS07120
gene id: 1224164:B843_RS07120
uniprot id: W5Y1N1
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

1224164:B843 RS06635
gene id: 1224164:B843_RS06635
uniprot id: W5Y0F8
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS08430
gene id: 1224164:B843_RS08430
uniprot id: W5Y957
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS05825
gene id: 1224164:B843_RS05825
uniprot id: W5Y034
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1224164:B843 RS03440
gene id: 1224164:B843_RS03440
uniprot id: W5XYJ1
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS12995
gene id: 1224164:B843_RS12995
uniprot id: W5Y4Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

1224164:B843 RS04840
gene id: 1224164:B843_RS04840
uniprot id: W5Y0E4
names: Similarity
messages: Belongs to the histone deacetylase family.

1224164:B843 RS05850
gene id: 1224164:B843_RS05850
uniprot id: W5Y038
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1224164:B843 RS08665
gene id: 1224164:B843_RS08665
uniprot id: W5Y2I3
names: Similarity
messages: Belongs to the P(II) protein family.

1224164:B843 RS10680
gene id: 1224164:B843_RS10680
uniprot id: W5Y3M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

1224164:B843 RS11275
gene id: 1224164:B843_RS11275
uniprot id: W5Y3X0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1224164:B843 RS03935
gene id: 1224164:B843_RS03935
uniprot id: W5Y6M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

1224164:B843 RS05265
gene id: 1224164:B843_RS05265
uniprot id: W5XZN1
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1224164:B843 RS09185
gene id: 1224164:B843_RS09185
uniprot id: W5Y2Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Cell membrane
messages: Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.

1224164:B843 RS08565
gene id: 1224164:B843_RS08565
uniprot id: W5Y2G0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS02310
gene id: 1224164:B843_RS02310
uniprot id: W5XYV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1224164:B843 RS14045
gene id: 1224164:B843_RS14045
uniprot id: W5Y526
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS12575
gene id: 1224164:B843_RS12575
uniprot id: W5Y4Q9
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS09655
gene id: 1224164:B843_RS09655
uniprot id: W5Y347
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1224164:B843 RS02815
gene id: 1224164:B843_RS02815
uniprot id: W5XY66
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1224164:B843 RS09355
gene id: 1224164:B843_RS09355
uniprot id: W5Y2V4
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1224164:B843 RS12020
gene id: 1224164:B843_RS12020
uniprot id: W5Y3D0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

1224164:B843 RS10775
gene id: 1224164:B843_RS10775
uniprot id: W5Y2T1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1224164:B843 RS08560
gene id: 1224164:B843_RS08560
uniprot id: W5Y2C3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

1224164:B843 RS03005
gene id: 1224164:B843_RS03005
uniprot id: W5XZ71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224164:B843 RS07275
gene id: 1224164:B843_RS07275
uniprot id: W5Y1Q4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS06990
gene id: 1224164:B843_RS06990
uniprot id: W5Y1F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

1224164:B843 RS04035
gene id: 1224164:B843_RS04035
uniprot id: W5XZ07
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS05640
gene id: 1224164:B843_RS05640
uniprot id: W5XZV7
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

1224164:B843 RS06345
gene id: 1224164:B843_RS06345
uniprot id: W5Y803
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1224164:B843 RS06715
gene id: 1224164:B843_RS06715
uniprot id: W5Y1F6
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1224164:B843 RS02390
gene id: 1224164:B843_RS02390
uniprot id: W5XXZ5
names: Function
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.

1224164:B843 RS05880
gene id: 1224164:B843_RS05880
uniprot id: W5Y7T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1224164:B843 RS09615
gene id: 1224164:B843_RS09615
uniprot id: W5Y250
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1224164:B843 RS10365
gene id: 1224164:B843_RS10365
uniprot id: W5Y3L9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1224164:B843 RS05255
gene id: 1224164:B843_RS05255
uniprot id: W5Y0J0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MshB deacetylase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.

1224164:B843 RS11220
gene id: 1224164:B843_RS11220
uniprot id: W5Y2Z5
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

1224164:B843 RS12500
gene id: 1224164:B843_RS12500
uniprot id: W5YBE8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1224164:B843 RS11915
gene id: 1224164:B843_RS11915
uniprot id: W5Y3A0
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1224164:B843 RS01745
gene id: 1224164:B843_RS01745
uniprot id: W5XYI3
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

1224164:B843 RS13005
gene id: 1224164:B843_RS13005
uniprot id: W5Y3Y2
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS00705
gene id: 1224164:B843_RS00705
uniprot id: W5XXX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

1224164:B843 RS12735
gene id: 1224164:B843_RS12735
uniprot id: W5Y4Y4
names: Similarity
messages: Belongs to the FPG family.

1224164:B843 RS08835
gene id: 1224164:B843_RS08835
uniprot id: W5Y9D0
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS13765
gene id: 1224164:B843_RS13765
uniprot id: W5XZV0
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS04850
gene id: 1224164:B843_RS04850
uniprot id: W5XZJ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS12380
gene id: 1224164:B843_RS12380
uniprot id: W5Y4I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS03955
gene id: 1224164:B843_RS03955
uniprot id: W5XYY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1224164:B843 RS08295
gene id: 1224164:B843_RS08295
uniprot id: W5Y1B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1224164:B843 RS13100
gene id: 1224164:B843_RS13100
uniprot id: W5Y544
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1224164:B843 RS03690
gene id: 1224164:B843_RS03690
uniprot id: W5XZJ5
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

1224164:B843 RS08105
gene id: 1224164:B843_RS08105
uniprot id: W5Y909
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1224164:B843 RS09945
gene id: 1224164:B843_RS09945
uniprot id: W5Y396
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1224164:B843 RS01260
gene id: 1224164:B843_RS01260
uniprot id: W5XY79
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS04885
gene id: 1224164:B843_RS04885
uniprot id: W5Y0D2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1224164:B843 RS12460
gene id: 1224164:B843_RS12460
uniprot id: W5Y4Q6
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1224164:B843 RS12955
gene id: 1224164:B843_RS12955
uniprot id: W5Y3X2
names: Function
names: Similarity
messages: Belongs to the TrpF family.
messages: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain.
messages: In the C-terminal section; belongs to the TrpF family.
messages: In the N-terminal section; belongs to the TrpC family.

1224164:B843 RS06155
gene id: 1224164:B843_RS06155
uniprot id: W5Y7X8
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1224164:B843 RS04530
gene id: 1224164:B843_RS04530
uniprot id: W5Y708
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1224164:B843 RS05890
gene id: 1224164:B843_RS05890
uniprot id: W5Y0Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

1224164:B843 RS04220
gene id: 1224164:B843_RS04220
uniprot id: W5Y006
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1224164:B843 RS09435
gene id: 1224164:B843_RS09435
uniprot id: W5Y301
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane

1224164:B843 RS09915
gene id: 1224164:B843_RS09915
uniprot id: W5Y9Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1224164:B843 RS02175
gene id: 1224164:B843_RS02175
uniprot id: W5Y5Q1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1224164:B843 RS10810
gene id: 1224164:B843_RS10810
uniprot id: W5Y2P5
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1224164:B843 RS12965
gene id: 1224164:B843_RS12965
uniprot id: W5YBN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1224164:B843 RS06340
gene id: 1224164:B843_RS06340
uniprot id: W5Y0A6
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1224164:B843 RS01945
gene id: 1224164:B843_RS01945
uniprot id: W5XXL1
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS10085
gene id: 1224164:B843_RS10085
uniprot id: W5Y3D1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1224164:B843 RS06605
gene id: 1224164:B843_RS06605
uniprot id: W5Y0C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1224164:B843 RS06375
gene id: 1224164:B843_RS06375
uniprot id: W5Y139
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS04590
gene id: 1224164:B843_RS04590
uniprot id: W5Y079
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

1224164:B843 RS12940
gene id: 1224164:B843_RS12940
uniprot id: W5YBM9
names: Cofactor
names: Similarity
messages: Belongs to the anthranilate synthase component I family.
messages: Binds 1 Mg(2+) ion per subunit.

1224164:B843 RS05005
gene id: 1224164:B843_RS05005
uniprot id: W5Y0E9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.
messages: Belongs to the MshB deacetylase family. Mca subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Monomer.

1224164:B843 RS05600
gene id: 1224164:B843_RS05600
uniprot id: W5XZZ2
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

1224164:B843 RS00110
gene id: 1224164:B843_RS00110
uniprot id: W5XWP1
names: Similarity
messages: Belongs to the AHA1 family.

1224164:B843 RS10750
gene id: 1224164:B843_RS10750
uniprot id: W5Y2S9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1224164:B843 RS08025
gene id: 1224164:B843_RS08025
uniprot id: W5Y1A5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1224164:B843 RS01585
gene id: 1224164:B843_RS01585
uniprot id: W5Y5C0
names: Similarity
messages: Belongs to the OsmC/Ohr family.

1224164:B843 RS00405
gene id: 1224164:B843_RS00405
uniprot id: W5XXS9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS02240
gene id: 1224164:B843_RS02240
uniprot id: W5XXS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1224164:B843 RS09725
gene id: 1224164:B843_RS09725
uniprot id: W5Y324
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS07820
gene id: 1224164:B843_RS07820
uniprot id: W5Y8Y2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1224164:B843 RS12115
gene id: 1224164:B843_RS12115
uniprot id: W5Y4I5
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS07795
gene id: 1224164:B843_RS07795
uniprot id: W5Y8X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1224164:B843 RS04945
gene id: 1224164:B843_RS04945
uniprot id: W5Y0E0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1224164:B843 RS06610
gene id: 1224164:B843_RS06610
uniprot id: W5Y0F2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1224164:B843 RS07410
gene id: 1224164:B843_RS07410
uniprot id: W5Y0X9
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS09030
gene id: 1224164:B843_RS09030
uniprot id: W5Y9G5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1224164:B843 RS05370
gene id: 1224164:B843_RS05370
uniprot id: W5XZV9
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

1224164:B843 RS04415
gene id: 1224164:B843_RS04415
uniprot id: W5Y046
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1224164:B843 RS08285
gene id: 1224164:B843_RS08285
uniprot id: W5Y276
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1224164:B843 RS03555
gene id: 1224164:B843_RS03555
uniprot id: W5XZL3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Cytoplasm
messages: Homotetramer.

1224164:B843 RS10355
gene id: 1224164:B843_RS10355
uniprot id: W5YA89
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-69 and Arg-72) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

1224164:B843 RS09710
gene id: 1224164:B843_RS09710
uniprot id: W5Y1Z6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm

1224164:B843 RS08505
gene id: 1224164:B843_RS08505
uniprot id: W5Y969
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1224164:B843 RS00805
gene id: 1224164:B843_RS00805
uniprot id: W5XXZ3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1224164:B843 RS06005
gene id: 1224164:B843_RS06005
uniprot id: W5Y7V3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1224164:B843 RS08510
gene id: 1224164:B843_RS08510
uniprot id: W5Y2B5
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1224164:B843 RS09935
gene id: 1224164:B843_RS09935
uniprot id: W5Y2B3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1224164:B843 RS01910
gene id: 1224164:B843_RS01910
uniprot id: W5XYK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

1224164:B843 RS02225
gene id: 1224164:B843_RS02225
uniprot id: W5Y5R0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1224164:B843 RS08365
gene id: 1224164:B843_RS08365
uniprot id: W5Y2C4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1224164:B843 RS07745
gene id: 1224164:B843_RS07745
uniprot id: W5Y8X1
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1224164:B843 RS09835
gene id: 1224164:B843_RS09835
uniprot id: W5Y227
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS07585
gene id: 1224164:B843_RS07585
uniprot id: W5Y128
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1224164:B843 RS10685
gene id: 1224164:B843_RS10685
uniprot id: W5Y3R4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

1224164:B843 RS00190
gene id: 1224164:B843_RS00190
uniprot id: W5Y4N1
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS04345
gene id: 1224164:B843_RS04345
uniprot id: W5XZ06
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1224164:B843 RS02790
gene id: 1224164:B843_RS02790
uniprot id: W5XY62
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS01330
gene id: 1224164:B843_RS01330
uniprot id: W5Y570
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS09330
gene id: 1224164:B843_RS09330
uniprot id: W5Y9M7
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS01215
gene id: 1224164:B843_RS01215
uniprot id: W5XXE9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1224164:B843 RS10700
gene id: 1224164:B843_RS10700
uniprot id: W5YAE4
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

1224164:B843 RS09360
gene id: 1224164:B843_RS09360
uniprot id: W5Y2Y7
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS00170
gene id: 1224164:B843_RS00170
uniprot id: W5XXN1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1224164:B843 RS09525
gene id: 1224164:B843_RS09525
uniprot id: W5Y0D8
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

1224164:B843 RS01995
gene id: 1224164:B843_RS01995
uniprot id: W5XXM1
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Could possibly oxidize fatty acids using specific components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS06085
gene id: 1224164:B843_RS06085
uniprot id: W5Y0Y5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1224164:B843 RS07870
gene id: 1224164:B843_RS07870
uniprot id: W5Y8Y9
names: Similarity
messages: Belongs to the DyP-type peroxidase family.

1224164:B843 RS05905
gene id: 1224164:B843_RS05905
uniprot id: W5Y7T5
names: Similarity
messages: Belongs to the UPF0045 family.

1224164:B843 RS07780
gene id: 1224164:B843_RS07780
uniprot id: W5Y233
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1224164:B843 RS01150
gene id: 1224164:B843_RS01150
uniprot id: W5XY48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

1224164:B843 RS06010
gene id: 1224164:B843_RS06010
uniprot id: W5Y0X0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1224164:B843 RS08795
gene id: 1224164:B843_RS08795
uniprot id: W5Y2L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1224164:B843 RS02170
gene id: 1224164:B843_RS02170
uniprot id: W5XXY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1224164:B843 RS02355
gene id: 1224164:B843_RS02355
uniprot id: W5XYV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

1224164:B843 RS02670
gene id: 1224164:B843_RS02670
uniprot id: W5XYC2
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1224164:B843 RS10075
gene id: 1224164:B843_RS10075
uniprot id: W5Y2H1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1224164:B843 RS00635
gene id: 1224164:B843_RS00635
uniprot id: W5XWY2
names: Similarity
messages: Belongs to the UPF0145 family.

1224164:B843 RS10395
gene id: 1224164:B843_RS10395
uniprot id: W5Y3M3
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

1224164:B843 RS04200
gene id: 1224164:B843_RS04200
uniprot id: W5XYX4
names: Similarity
messages: Belongs to the AccD/PCCB family.

1224164:B843 RS01595
gene id: 1224164:B843_RS01595
uniprot id: W5XYE8
names: Subcellular Location Annotation
messages: Cytoplasm

1224164:B843 RS07145
gene id: 1224164:B843_RS07145
uniprot id: W5Y1N5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1224164:B843 RS10615
gene id: 1224164:B843_RS10615
uniprot id: W5Y2L1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1224164:B843 RS02245
gene id: 1224164:B843_RS02245
uniprot id: W5XY02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1224164:B843 RS08350
gene id: 1224164:B843_RS08350
uniprot id: W5Y1G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1224164:B843 RS12675
gene id: 1224164:B843_RS12675
uniprot id: W5YBI8
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS07670
gene id: 1224164:B843_RS07670
uniprot id: W5Y1X1
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

1224164:B843 RS07575
gene id: 1224164:B843_RS07575
uniprot id: W5Y1Z7
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

1224164:B843 RS02440
gene id: 1224164:B843_RS02440
uniprot id: W5XY05
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1224164:B843 RS07445
gene id: 1224164:B843_RS07445
uniprot id: W5Y1S6
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

1224164:B843 RS10640
gene id: 1224164:B843_RS10640
uniprot id: W5Y2L5
names: Similarity
messages: Belongs to the peptidase S58 family.

1224164:B843 RS04290
gene id: 1224164:B843_RS04290
uniprot id: W5Y0D8
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

1224164:B843 RS09150
gene id: 1224164:B843_RS09150
uniprot id: W5Y1V2
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.
messages: Homodimer.

1224164:B843 RS04050
gene id: 1224164:B843_RS04050
uniprot id: W5XZX2
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS05510
gene id: 1224164:B843_RS05510
uniprot id: W5Y0N9
names: Similarity
messages: Belongs to the HypD family.

1224164:B843 RS06975
gene id: 1224164:B843_RS06975
uniprot id: W5Y0I4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS10895
gene id: 1224164:B843_RS10895
uniprot id: W5YAG9
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

1224164:B843 RS04680
gene id: 1224164:B843_RS04680
uniprot id: W5Y741
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

1224164:B843 RS02780
gene id: 1224164:B843_RS02780
uniprot id: W5XZ28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

1224164:B843 RS05015
gene id: 1224164:B843_RS05015
uniprot id: W5XZJ7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS02840
gene id: 1224164:B843_RS02840
uniprot id: W5XY71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS08815
gene id: 1224164:B843_RS08815
uniprot id: W5Y2H2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1224164:B843 RS02250
gene id: 1224164:B843_RS02250
uniprot id: W5Y5R6
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1224164:B843 RS07390
gene id: 1224164:B843_RS07390
uniprot id: W5Y8Q5
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1224164:B843 RS05415
gene id: 1224164:B843_RS05415
uniprot id: W5XZR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1224164:B843 RS06200
gene id: 1224164:B843_RS06200
uniprot id: W5Y086
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1224164:B843 RS11890
gene id: 1224164:B843_RS11890
uniprot id: W5Y393
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1224164:B843 RS02220
gene id: 1224164:B843_RS02220
uniprot id: W5XXZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1224164:B843 RS01735
gene id: 1224164:B843_RS01735
uniprot id: W5Y5F4
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1224164:B843 RS01370
gene id: 1224164:B843_RS01370
uniprot id: W5XXC0
names: Similarity
messages: Belongs to the FAD-binding monooxygenase family.

1224164:B843 RS07020
gene id: 1224164:B843_RS07020
uniprot id: W5Y1L7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1224164:B843 RS05545
gene id: 1224164:B843_RS05545
uniprot id: W5XZT8
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1224164:B843 RS11075
gene id: 1224164:B843_RS11075
uniprot id: W5YAK0
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1224164:B843 RS06950
gene id: 1224164:B843_RS06950
uniprot id: W5Y0H9
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS08915
gene id: 1224164:B843_RS08915
uniprot id: W5Y2N7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

1224164:B843 RS10080
gene id: 1224164:B843_RS10080
uniprot id: W5YA42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1224164:B843 RS02040
gene id: 1224164:B843_RS02040
uniprot id: W5XYP7
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

1224164:B843 RS09005
gene id: 1224164:B843_RS09005
uniprot id: W5Y9F5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1224164:B843 RS06710
gene id: 1224164:B843_RS06710
uniprot id: W5Y1A3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS09600
gene id: 1224164:B843_RS09600
uniprot id: W5Y300
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

1224164:B843 RS03905
gene id: 1224164:B843_RS03905
uniprot id: W5XYY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

1224164:B843 RS09755
gene id: 1224164:B843_RS09755
uniprot id: W5Y371
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS08830
gene id: 1224164:B843_RS08830
uniprot id: W5Y1Q0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1224164:B843 RS05525
gene id: 1224164:B843_RS05525
uniprot id: W5XZY1
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

1224164:B843 RS08305
gene id: 1224164:B843_RS08305
uniprot id: W5Y937
names: Similarity
messages: Belongs to the ribF family.

1224164:B843 RS11610
gene id: 1224164:B843_RS11610
uniprot id: W5Y364
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1224164:B843 RS02900
gene id: 1224164:B843_RS02900
uniprot id: W5Y651
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

1224164:B843 RS07520
gene id: 1224164:B843_RS07520
uniprot id: W5Y1T7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1224164:B843 RS10535
gene id: 1224164:B843_RS10535
uniprot id: W5Y2J6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1224164:B843 RS02105
gene id: 1224164:B843_RS02105
uniprot id: W5XYP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1224164:B843 RS01695
gene id: 1224164:B843_RS01695
uniprot id: W5XYH2
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1224164:B843 RS09895
gene id: 1224164:B843_RS09895
uniprot id: W5Y362
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS08655
gene id: 1224164:B843_RS08655
uniprot id: W5Y996
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1224164:B843 RS00865
gene id: 1224164:B843_RS00865
uniprot id: W5XY04
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS02100
gene id: 1224164:B843_RS02100
uniprot id: W5Y5N4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1224164:B843 RS11360
gene id: 1224164:B843_RS11360
uniprot id: W5Y2Z7
names: Similarity
messages: Belongs to the peptidase S13 family.

1224164:B843 RS09620
gene id: 1224164:B843_RS09620
uniprot id: W5Y9T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1224164:B843 RS02210
gene id: 1224164:B843_RS02210
uniprot id: W5XYT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1224164:B843 RS08380
gene id: 1224164:B843_RS08380
uniprot id: W5Y949
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

1224164:B843 RS02075
gene id: 1224164:B843_RS02075
uniprot id: W5Y5M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1224164:B843 RS08705
gene id: 1224164:B843_RS08705
uniprot id: W5Y9A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1224164:B843 RS05025
gene id: 1224164:B843_RS05025
uniprot id: W5Y7D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm

1224164:B843 RS10530
gene id: 1224164:B843_RS10530
uniprot id: W5Y3P2
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Could possibly oxidize fatty acids using specific components.

1224164:B843 RS07630
gene id: 1224164:B843_RS07630
uniprot id: W5Y0Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1224164:B843 RS00350
gene id: 1224164:B843_RS00350
uniprot id: W5XXR1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1224164:B843 RS04905
gene id: 1224164:B843_RS04905
uniprot id: W5XZN8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1224164:B843 RS10155
gene id: 1224164:B843_RS10155
uniprot id: W5Y2D0
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group II subfamily.

1224164:B843 RS10140
gene id: 1224164:B843_RS10140
uniprot id: W5YA53
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1224164:B843 RS12870
gene id: 1224164:B843_RS12870
uniprot id: W5Y4V8
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1224164:B843 RS11755
gene id: 1224164:B843_RS11755
uniprot id: W5Y471
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS12655
gene id: 1224164:B843_RS12655
uniprot id: W5Y4S0
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1224164:B843 RS11450
gene id: 1224164:B843_RS11450
uniprot id: W5Y453
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS09825
gene id: 1224164:B843_RS09825
uniprot id: W5Y345
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS09870
gene id: 1224164:B843_RS09870
uniprot id: W5Y357
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1224164:B843 RS05645
gene id: 1224164:B843_RS05645
uniprot id: W5Y002
names: Similarity
messages: Belongs to the PrpD family.

1224164:B843 RS08180
gene id: 1224164:B843_RS08180
uniprot id: W5Y919
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

1224164:B843 RS07470
gene id: 1224164:B843_RS07470
uniprot id: W5Y1T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm

1224164:B843 RS01700
gene id: 1224164:B843_RS01700
uniprot id: W5XXG7
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

1224164:B843 RS13035
gene id: 1224164:B843_RS13035
uniprot id: W5Y416
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

1224164:B843 RS11455
gene id: 1224164:B843_RS11455
uniprot id: W5Y313
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS07680
gene id: 1224164:B843_RS07680
uniprot id: W5Y108
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1224164:B843 RS00420
gene id: 1224164:B843_RS00420
uniprot id: W5Y4R8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS03860
gene id: 1224164:B843_RS03860
uniprot id: W5Y6L3
names: Similarity
messages: Belongs to the acyl-CoA oxidase family.

1224164:B843 RS09855
gene id: 1224164:B843_RS09855
uniprot id: W5Y232
names: Similarity
messages: Belongs to the EfeM/EfeO family.

1224164:B843 RS08355
gene id: 1224164:B843_RS08355
uniprot id: W5Y944
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1224164:B843 RS10975
gene id: 1224164:B843_RS10975
uniprot id: W5Y3R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1224164:B843 RS03040
gene id: 1224164:B843_RS03040
uniprot id: W5XYA7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1224164:B843 RS05100
gene id: 1224164:B843_RS05100
uniprot id: W5Y7E4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1224164:B843 RS09140
gene id: 1224164:B843_RS09140
uniprot id: W5Y2T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

1224164:B843 RS08040
gene id: 1224164:B843_RS08040
uniprot id: W5Y272
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1224164:B843 RS09275
gene id: 1224164:B843_RS09275
uniprot id: W5Y1X3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1224164:B843 RS06195
gene id: 1224164:B843_RS06195
uniprot id: W5Y056
names: Similarity
messages: Belongs to the isochorismate synthase family.

1224164:B843 RS05945
gene id: 1224164:B843_RS05945
uniprot id: W5Y013
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1224164:B843 RS02620
gene id: 1224164:B843_RS02620
uniprot id: W5XYB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

1224164:B843 RS05655
gene id: 1224164:B843_RS05655
uniprot id: W5Y0R6
names: Similarity
messages: Belongs to the citrate synthase family.

1224164:B843 RS01555
gene id: 1224164:B843_RS01555
uniprot id: W5XXJ8
names: Similarity
messages: Belongs to the GSP E family.

1224164:B843 RS09230
gene id: 1224164:B843_RS09230
uniprot id: W5Y9K5
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

1224164:B843 RS01100
gene id: 1224164:B843_RS01100
uniprot id: W5XY39
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

1224164:B843 RS11945
gene id: 1224164:B843_RS11945
uniprot id: W5Y3B9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

1224164:B843 RS01190
gene id: 1224164:B843_RS01190
uniprot id: W5XXE4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport.

1224164:B843 RS12415
gene id: 1224164:B843_RS12415
uniprot id: W5Y3K7
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

1224164:B843 RS04930
gene id: 1224164:B843_RS04930
uniprot id: W5XZI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1224164:B843 RS11525
gene id: 1224164:B843_RS11525
uniprot id: W5Y467
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Membrane

1224164:B843 RS10990
gene id: 1224164:B843_RS10990
uniprot id: W5Y2W0
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS01275
gene id: 1224164:B843_RS01275
uniprot id: W5Y560
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1224164:B843 RS11585
gene id: 1224164:B843_RS11585
uniprot id: W5Y360
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

1224164:B843 RS08980
gene id: 1224164:B843_RS08980
uniprot id: W5Y9F2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1224164:B843 RS02215
gene id: 1224164:B843_RS02215
uniprot id: W5XXR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1224164:B843 RS06865
gene id: 1224164:B843_RS06865
uniprot id: W5Y1D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1224164:B843 RS09925
gene id: 1224164:B843_RS09925
uniprot id: W5Y3A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1224164:B843 RS07110
gene id: 1224164:B843_RS07110
uniprot id: W5Y8H4
names: Similarity
messages: Belongs to the peptidase M18 family.

1224164:B843 RS07960
gene id: 1224164:B843_RS07960
uniprot id: W5Y218
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1224164:B843 RS02230
gene id: 1224164:B843_RS02230
uniprot id: W5XYS2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1224164:B843 RS07450
gene id: 1224164:B843_RS07450
uniprot id: W5Y1X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

1224164:B843 RS02480
gene id: 1224164:B843_RS02480
uniprot id: W5XYX7
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1224164:B843 RS00735
gene id: 1224164:B843_RS00735
uniprot id: W5XX03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 85 family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS05105
gene id: 1224164:B843_RS05105
uniprot id: W5Y0G3
names: Similarity
messages: Belongs to the FBPase class 2 family.

1224164:B843 RS02315
gene id: 1224164:B843_RS02315
uniprot id: W5XXU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1224164:B843 RS08495
gene id: 1224164:B843_RS08495
uniprot id: W5Y1E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1224164:B843 RS12960
gene id: 1224164:B843_RS12960
uniprot id: W5Y402
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1224164:B843 RS00005
gene id: 1224164:B843_RS00005
uniprot id: W5XWU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1224164:B843 RS01565
gene id: 1224164:B843_RS01565
uniprot id: W5XYC5
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS11765
gene id: 1224164:B843_RS11765
uniprot id: W5Y374
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1224164:B843 RS02025
gene id: 1224164:B843_RS02025
uniprot id: W5XXV9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

1224164:B843 RS01885
gene id: 1224164:B843_RS01885
uniprot id: W5XYK2
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1224164:B843 RS02255
gene id: 1224164:B843_RS02255
uniprot id: W5XYS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1224164:B843 RS08290
gene id: 1224164:B843_RS08290
uniprot id: W5Y2B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1224164:B843 RS02955
gene id: 1224164:B843_RS02955
uniprot id: W5XZ61
names: Similarity
messages: Belongs to the AccD/PCCB family.

1224164:B843 RS02300
gene id: 1224164:B843_RS02300
uniprot id: W5Y5S6
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

1224164:B843 RS00105
gene id: 1224164:B843_RS00105
uniprot id: W5XXL9
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS07015
gene id: 1224164:B843_RS07015
uniprot id: W5Y1G2
names: Similarity
messages: Belongs to the CobH/CbiC family.

1224164:B843 RS08060
gene id: 1224164:B843_RS08060
uniprot id: W5Y240
names: Function
names: Similarity
names: Subunit
messages: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
messages: Belongs to the AhpD family.
messages: Homotrimer.

1224164:B843 RS05180
gene id: 1224164:B843_RS05180
uniprot id: W5Y0H8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS03060
gene id: 1224164:B843_RS03060
uniprot id: W5XZC8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1224164:B843 RS04185
gene id: 1224164:B843_RS04185
uniprot id: W5Y6S9
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

1224164:B843 RS05760
gene id: 1224164:B843_RS05760
uniprot id: W5Y0T3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

1224164:B843 RS07940
gene id: 1224164:B843_RS07940
uniprot id: W5Y255
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ChdC family. Type 2 subfamily.
messages: Fe-coproporphyrin III acts as both substrate and redox cofactor.
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate.

1224164:B843 RS01625
gene id: 1224164:B843_RS01625
uniprot id: W5XXL7
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.

1224164:B843 RS06325
gene id: 1224164:B843_RS06325
uniprot id: W5Y129
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1224164:B843 RS05205
gene id: 1224164:B843_RS05205
uniprot id: W5Y0I2
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS10410
gene id: 1224164:B843_RS10410
uniprot id: W5YA97
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS07500
gene id: 1224164:B843_RS07500
uniprot id: W5Y1Y3
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1224164:B843 RS02585
gene id: 1224164:B843_RS02585
uniprot id: W5XZ36
names: Similarity
messages: Belongs to the AAE transporter (TC 2.A.81) family.

1224164:B843 RS11335
gene id: 1224164:B843_RS11335
uniprot id: W5Y2Z2
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1224164:B843 RS08880
gene id: 1224164:B843_RS08880
uniprot id: W5Y1Q9
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1224164:B843 RS08685
gene id: 1224164:B843_RS08685
uniprot id: W5Y2E7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1224164:B843 RS07130
gene id: 1224164:B843_RS07130
uniprot id: W5Y0Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane

1224164:B843 RS05520
gene id: 1224164:B843_RS05520
uniprot id: W5XZT3
names: Similarity
messages: Belongs to the HypE family.

1224164:B843 RS05835
gene id: 1224164:B843_RS05835
uniprot id: W5Y0U5
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS03235
gene id: 1224164:B843_RS03235
uniprot id: W5XZF6
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1224164:B843 RS02980
gene id: 1224164:B843_RS02980
uniprot id: W5XZ66
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1224164:B843 RS08785
gene id: 1224164:B843_RS08785
uniprot id: W5Y9C1
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1224164:B843 RS07560
gene id: 1224164:B843_RS07560
uniprot id: W5Y123
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1224164:B843 RS03375
gene id: 1224164:B843_RS03375
uniprot id: W5Y6C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

1224164:B843 RS12145
gene id: 1224164:B843_RS12145
uniprot id: W5Y3E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1224164:B843 RS09200
gene id: 1224164:B843_RS09200
uniprot id: W5Y1W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

1224164:B843 RS07810
gene id: 1224164:B843_RS07810
uniprot id: W5Y132
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

1224164:B843 RS06470
gene id: 1224164:B843_RS06470
uniprot id: W5Y0C5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1224164:B843 RS04685
gene id: 1224164:B843_RS04685
uniprot id: W5Y054
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1224164:B843 RS09550
gene id: 1224164:B843_RS09550
uniprot id: W5Y323
names: Similarity
messages: Belongs to the ribonuclease N1/T1 family.

1224164:B843 RS02550
gene id: 1224164:B843_RS02550
uniprot id: W5Y5Z8
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1224164:B843 RS04065
gene id: 1224164:B843_RS04065
uniprot id: W5Y6Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1224164:B843 RS09440
gene id: 1224164:B843_RS09440
uniprot id: W5Y1U9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

1224164:B843 RS09055
gene id: 1224164:B843_RS09055
uniprot id: W5Y9H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1224164:B843 RS09255
gene id: 1224164:B843_RS09255
uniprot id: W5Y9L1
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1224164:B843 RS01820
gene id: 1224164:B843_RS01820
uniprot id: W5XYK1
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1224164:B843 RS09465
gene id: 1224164:B843_RS09465
uniprot id: W5Y306
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

1224164:B843 RS07235
gene id: 1224164:B843_RS07235
uniprot id: W5Y0S6
names: Subunit
messages: Heterodimer of an alpha and a beta chain.

1224164:B843 RS07140
gene id: 1224164:B843_RS07140
uniprot id: W5Y1I5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1224164:B843 RS11690
gene id: 1224164:B843_RS11690
uniprot id: W5Y358
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

1224164:B843 RS13055
gene id: 1224164:B843_RS13055
uniprot id: W5Y3Z4
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS13065
gene id: 1224164:B843_RS13065
uniprot id: W5YBP9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1224164:B843 RS07310
gene id: 1224164:B843_RS07310
uniprot id: W5Y0T8
names: Similarity
messages: Belongs to the UPF0237 family.

1224164:B843 RS09940
gene id: 1224164:B843_RS09940
uniprot id: W5YA05
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1224164:B843 RS00580
gene id: 1224164:B843_RS00580
uniprot id: W5XXV8
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1224164:B843 RS06515
gene id: 1224164:B843_RS06515
uniprot id: W5Y0A7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1224164:B843 RS04755
gene id: 1224164:B843_RS04755
uniprot id: W5Y759
names: Cofactor
messages: Can also use Mn(2+) ion.

1224164:B843 RS02770
gene id: 1224164:B843_RS02770
uniprot id: W5XYD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224164:B843 RS03665
gene id: 1224164:B843_RS03665
uniprot id: W5Y6H8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1224164:B843 RS05870
gene id: 1224164:B843_RS05870
uniprot id: W5XZZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1224164:B843 RS01280
gene id: 1224164:B843_RS01280
uniprot id: W5XY68
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

1224164:B843 RS02350
gene id: 1224164:B843_RS02350
uniprot id: W5Y5W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS11910
gene id: 1224164:B843_RS11910
uniprot id: W5Y4E5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1224164:B843 RS12670
gene id: 1224164:B843_RS12670
uniprot id: W5Y3U7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1224164:B843 RS04735
gene id: 1224164:B843_RS04735
uniprot id: W5Y066
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS13070
gene id: 1224164:B843_RS13070
uniprot id: W5Y4Z9
names: Similarity
messages: Belongs to the thioredoxin family.

1224164:B843 RS02540
gene id: 1224164:B843_RS02540
uniprot id: W5XY22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1224164:B843 RS02535
gene id: 1224164:B843_RS02535
uniprot id: W5XZ29
names: Similarity
messages: Belongs to the WXG100 family.

1224164:B843 RS14015
gene id: 1224164:B843_RS14015
uniprot id: W5Y7Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

1224164:B843 RS00090
gene id: 1224164:B843_RS00090
uniprot id: W5XXL5
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS12330
gene id: 1224164:B843_RS12330
uniprot id: W5Y4H6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

1224164:B843 RS12990
gene id: 1224164:B843_RS12990
uniprot id: W5YBN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

1224164:B843 RS11440
gene id: 1224164:B843_RS11440
uniprot id: W5YAS9
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS11420
gene id: 1224164:B843_RS11420
uniprot id: W5Y403
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

1224164:B843 RS04475
gene id: 1224164:B843_RS04475
uniprot id: W5XZA5
names: Similarity
messages: Belongs to the AccD/PCCB family.

1224164:B843 RS03025
gene id: 1224164:B843_RS03025
uniprot id: W5Y672
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

1224164:B843 RS11745
gene id: 1224164:B843_RS11745
uniprot id: W5Y385
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

1224164:B843 RS07070
gene id: 1224164:B843_RS07070
uniprot id: W5Y1M5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1224164:B843 RS11435
gene id: 1224164:B843_RS11435
uniprot id: W5Y331
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1224164:B843 RS02865
gene id: 1224164:B843_RS02865
uniprot id: W5XY76
names: Similarity
messages: Belongs to the peptidase C40 family.

1224164:B843 RS06900
gene id: 1224164:B843_RS06900
uniprot id: W5Y0G9
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS06775
gene id: 1224164:B843_RS06775
uniprot id: W5Y0I3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS11570
gene id: 1224164:B843_RS11570
uniprot id: W5Y434
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1224164:B843 RS09745
gene id: 1224164:B843_RS09745
uniprot id: W5Y9V4
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS07425
gene id: 1224164:B843_RS07425
uniprot id: W5Y1X2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

1224164:B843 RS01440
gene id: 1224164:B843_RS01440
uniprot id: W5Y590
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS02650
gene id: 1224164:B843_RS02650
uniprot id: W5Y617
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

1224164:B843 RS07705
gene id: 1224164:B843_RS07705
uniprot id: W5Y113
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS00280
gene id: 1224164:B843_RS00280
uniprot id: W5XXQ6
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS04835
gene id: 1224164:B843_RS04835
uniprot id: W5Y0A3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1224164:B843 RS09695
gene id: 1224164:B843_RS09695
uniprot id: W5Y9U5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1224164:B843 RS01525
gene id: 1224164:B843_RS01525
uniprot id: W5XYD1
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS03710
gene id: 1224164:B843_RS03710
uniprot id: W5Y6I7
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1224164:B843 RS04605
gene id: 1224164:B843_RS04605
uniprot id: W5Y726
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1224164:B843 RS08620
gene id: 1224164:B843_RS08620
uniprot id: W5Y1H1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

1224164:B843 RS10905
gene id: 1224164:B843_RS10905
uniprot id: W5Y3U4
names: Similarity
messages: Belongs to the PhoU family.

1224164:B843 RS02085
gene id: 1224164:B843_RS02085
uniprot id: W5XYQ4
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1224164:B843 RS03550
gene id: 1224164:B843_RS03550
uniprot id: W5XZG8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1224164:B843 RS08155
gene id: 1224164:B843_RS08155
uniprot id: W5Y915
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1224164:B843 RS10460
gene id: 1224164:B843_RS10460
uniprot id: W5YAA7
names: Similarity
messages: Belongs to the CsoR family.

1224164:B843 RS01125
gene id: 1224164:B843_RS01125
uniprot id: W5XY43
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1224164:B843 RS05565
gene id: 1224164:B843_RS05565
uniprot id: W5Y0U2
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

1224164:B843 RS10245
gene id: 1224164:B843_RS10245
uniprot id: W5Y2K2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1224164:B843 RS12830
gene id: 1224164:B843_RS12830
uniprot id: W5XZ69
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

1224164:B843 RS03920
gene id: 1224164:B843_RS03920
uniprot id: W5XZU5
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1224164:B843 RS08700
gene id: 1224164:B843_RS08700
uniprot id: W5Y1N0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

1224164:B843 RS05550
gene id: 1224164:B843_RS05550
uniprot id: W5XZY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

1224164:B843 RS06270
gene id: 1224164:B843_RS06270
uniprot id: W5Y7Z1
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

1224164:B843 RS02235
gene id: 1224164:B843_RS02235
uniprot id: W5XYT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1224164:B843 RS05410
gene id: 1224164:B843_RS05410
uniprot id: W5Y0S0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1224164:B843 RS05340
gene id: 1224164:B843_RS05340
uniprot id: W5Y0Q6
names: Similarity
messages: Belongs to the LOG family.

1224164:B843 RS01385
gene id: 1224164:B843_RS01385
uniprot id: W5XXH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

1224164:B843 RS04420
gene id: 1224164:B843_RS04420
uniprot id: W5XZ25
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1224164:B843 RS11340
gene id: 1224164:B843_RS11340
uniprot id: W5Y312
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1224164:B843 RS09665
gene id: 1224164:B843_RS09665
uniprot id: W5Y258
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1224164:B843 RS07675
gene id: 1224164:B843_RS07675
uniprot id: W5Y216
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1224164:B843 RS08690
gene id: 1224164:B843_RS08690
uniprot id: W5Y2I8
names: Similarity
messages: Belongs to the acylphosphatase family.

1224164:B843 RS07170
gene id: 1224164:B843_RS07170
uniprot id: W5Y1N9
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

1224164:B843 RS10710
gene id: 1224164:B843_RS10710
uniprot id: W5Y3R8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1224164:B843 RS02410
gene id: 1224164:B843_RS02410
uniprot id: W5XZ02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1224164:B843 RS05590
gene id: 1224164:B843_RS05590
uniprot id: W5Y0U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1224164:B843 RS10940
gene id: 1224164:B843_RS10940
uniprot id: W5Y2V2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. MshD subfamily.
messages: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1224164:B843 RS08525
gene id: 1224164:B843_RS08525
uniprot id: W5Y1K0
names: Similarity
messages: Belongs to the DprA/Smf family.

1224164:B843 RS05540
gene id: 1224164:B843_RS05540
uniprot id: W5Y0T9
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

1224164:B843 RS08760
gene id: 1224164:B843_RS08760
uniprot id: W5Y2G1
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

1224164:B843 RS02435
gene id: 1224164:B843_RS02435
uniprot id: W5XZ09
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1224164:B843 RS09510
gene id: 1224164:B843_RS09510
uniprot id: W5Y2Y6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1224164:B843 RS07180
gene id: 1224164:B843_RS07180
uniprot id: W5Y0R5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
messages: Monomer.

1224164:B843 RS12105
gene id: 1224164:B843_RS12105
uniprot id: W5YB43
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS02090
gene id: 1224164:B843_RS02090
uniprot id: W5XXN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1224164:B843 RS08415
gene id: 1224164:B843_RS08415
uniprot id: W5Y2D1
names: Similarity
messages: Belongs to the MQO family.

1224164:B843 RS08695
gene id: 1224164:B843_RS08695
uniprot id: W5Y1I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS08595
gene id: 1224164:B843_RS08595
uniprot id: W5Y1G8
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1224164:B843 RS01255
gene id: 1224164:B843_RS01255
uniprot id: W5XY63
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS05860
gene id: 1224164:B843_RS05860
uniprot id: W5Y0V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1224164:B843 RS06600
gene id: 1224164:B843_RS06600
uniprot id: W5Y1D5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1224164:B843 RS07545
gene id: 1224164:B843_RS07545
uniprot id: W5Y1V0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS02810
gene id: 1224164:B843_RS02810
uniprot id: W5XZ81
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1224164:B843 RS03610
gene id: 1224164:B843_RS03610
uniprot id: W5XYM2
names: Similarity
messages: Belongs to the DNA polymerase type-A family.

1224164:B843 RS01860
gene id: 1224164:B843_RS01860
uniprot id: W5XYJ7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1224164:B843 RS01270
gene id: 1224164:B843_RS01270
uniprot id: W5XXF5
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS08225
gene id: 1224164:B843_RS08225
uniprot id: W5Y1E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1224164:B843 RS05670
gene id: 1224164:B843_RS05670
uniprot id: W5Y004
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Membrane

1224164:B843 RS12560
gene id: 1224164:B843_RS12560
uniprot id: W5Y3Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1224164:B843 RS11365
gene id: 1224164:B843_RS11365
uniprot id: W5Y318
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1224164:B843 RS04110
gene id: 1224164:B843_RS04110
uniprot id: W5XZS5
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

1224164:B843 RS10025
gene id: 1224164:B843_RS10025
uniprot id: W5Y3F9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1224164:B843 RS09980
gene id: 1224164:B843_RS09980
uniprot id: W5Y292
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1224164:B843 RS09830
gene id: 1224164:B843_RS09830
uniprot id: W5Y387
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1224164:B843 RS07760
gene id: 1224164:B843_RS07760
uniprot id: W5Y120
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1224164:B843 RS04540
gene id: 1224164:B843_RS04540
uniprot id: W5Y070
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1224164:B843 RS01160
gene id: 1224164:B843_RS01160
uniprot id: W5XX78
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1224164:B843 RS04660
gene id: 1224164:B843_RS04660
uniprot id: W5Y051
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Belongs to the precorrin methyltransferase family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1224164:B843 RS11760
gene id: 1224164:B843_RS11760
uniprot id: W5Y4B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS06830
gene id: 1224164:B843_RS06830
uniprot id: W5Y8B0
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS09560
gene id: 1224164:B843_RS09560
uniprot id: W5Y236
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

1224164:B843 RS00270
gene id: 1224164:B843_RS00270
uniprot id: W5Y4P3
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS09190
gene id: 1224164:B843_RS09190
uniprot id: W5Y2V0
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 heme c groups covalently per subunit.
messages: Cell membrane
messages: Membrane
messages: The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.

1224164:B843 RS10185
gene id: 1224164:B843_RS10185
uniprot id: W5Y2I9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1224164:B843 RS05185
gene id: 1224164:B843_RS05185
uniprot id: W5Y0M7
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1224164:B843 RS11905
gene id: 1224164:B843_RS11905
uniprot id: W5Y498
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1224164:B843 RS09775
gene id: 1224164:B843_RS09775
uniprot id: W5Y334
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS06135
gene id: 1224164:B843_RS06135
uniprot id: W5Y0Z3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS08845
gene id: 1224164:B843_RS08845
uniprot id: W5Y2M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1224164:B843 RS05395
gene id: 1224164:B843_RS05395
uniprot id: W5XZW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

1224164:B843 RS08270
gene id: 1224164:B843_RS08270
uniprot id: W5Y1A1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS02830
gene id: 1224164:B843_RS02830
uniprot id: W5XZ39
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1224164:B843 RS09785
gene id: 1224164:B843_RS09785
uniprot id: W5Y215
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

1224164:B843 RS06320
gene id: 1224164:B843_RS06320
uniprot id: W5Y7Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1224164:B843 RS00015
gene id: 1224164:B843_RS00015
uniprot id: W5XXJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1224164:B843 RS02335
gene id: 1224164:B843_RS02335
uniprot id: W5XYX0
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS12650
gene id: 1224164:B843_RS12650
uniprot id: W5YBI5
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS11940
gene id: 1224164:B843_RS11940
uniprot id: W5Y3A4
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

1224164:B843 RS04125
gene id: 1224164:B843_RS04125
uniprot id: W5XZ27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1224164:B843 RS05245
gene id: 1224164:B843_RS05245
uniprot id: W5XZU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1224164:B843 RS07865
gene id: 1224164:B843_RS07865
uniprot id: W5Y177
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS03830
gene id: 1224164:B843_RS03830
uniprot id: W5Y6K9
names: Similarity
messages: Belongs to the AccD/PCCB family.

1224164:B843 RS05915
gene id: 1224164:B843_RS05915
uniprot id: W5Y0Z5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

1224164:B843 RS04795
gene id: 1224164:B843_RS04795
uniprot id: W5XZB6
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Could possibly oxidize fatty acids using specific components.

1224164:B843 RS13265
gene id: 1224164:B843_RS13265
uniprot id: W5Y237
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

1224164:B843 RS11210
gene id: 1224164:B843_RS11210
uniprot id: W5Y401
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1224164:B843 RS00695
gene id: 1224164:B843_RS00695
uniprot id: W5Y4V9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DyP-type peroxidase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.
messages: Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.

1224164:B843 RS03090
gene id: 1224164:B843_RS03090
uniprot id: W5XYB8
names: Caution
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1224164:B843 RS11350
gene id: 1224164:B843_RS11350
uniprot id: W5Y3Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

1224164:B843 RS05345
gene id: 1224164:B843_RS05345
uniprot id: W5XZP7
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

1224164:B843 RS04430
gene id: 1224164:B843_RS04430
uniprot id: W5Y6Y4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1224164:B843 RS01760
gene id: 1224164:B843_RS01760
uniprot id: W5Y5G1
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

1224164:B843 RS05820
gene id: 1224164:B843_RS05820
uniprot id: W5XZZ1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1224164:B843 RS06590
gene id: 1224164:B843_RS06590
uniprot id: W5Y856
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1224164:B843 RS00585
gene id: 1224164:B843_RS00585
uniprot id: W5XWX3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1224164:B843 RS09845
gene id: 1224164:B843_RS09845
uniprot id: W5Y351
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1224164:B843 RS10900
gene id: 1224164:B843_RS10900
uniprot id: W5Y3Q1
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1224164:B843 RS07625
gene id: 1224164:B843_RS07625
uniprot id: W5Y206
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

1224164:B843 RS10165
gene id: 1224164:B843_RS10165
uniprot id: W5YA57
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Catalyzes the reversible reductive amination of pyruvate to L-alanine.

1224164:B843 RS10430
gene id: 1224164:B843_RS10430
uniprot id: W5Y2N1
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS08130
gene id: 1224164:B843_RS08130
uniprot id: W5Y912
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1224164:B843 RS04760
gene id: 1224164:B843_RS04760
uniprot id: W5Y071
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Homotrimer.

1224164:B843 RS09060
gene id: 1224164:B843_RS09060
uniprot id: W5Y2M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1224164:B843 RS08600
gene id: 1224164:B843_RS08600
uniprot id: W5Y1L2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1224164:B843 RS04860
gene id: 1224164:B843_RS04860
uniprot id: W5Y0C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1224164:B843 RS10050
gene id: 1224164:B843_RS10050
uniprot id: W5Y3G4
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1224164:B843 RS05770
gene id: 1224164:B843_RS05770
uniprot id: W5XZY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1224164:B843 RS12410
gene id: 1224164:B843_RS12410
uniprot id: W5Y4P6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS04485
gene id: 1224164:B843_RS04485
uniprot id: W5Y015
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1224164:B843 RS10760
gene id: 1224164:B843_RS10760
uniprot id: W5Y3N7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1224164:B843 RS01920
gene id: 1224164:B843_RS01920
uniprot id: W5XXK5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

1224164:B843 RS11740
gene id: 1224164:B843_RS11740
uniprot id: W5Y369
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS01435
gene id: 1224164:B843_RS01435
uniprot id: W5XXI1
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS11240
gene id: 1224164:B843_RS11240
uniprot id: W5Y2X5
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1224164:B843 RS09235
gene id: 1224164:B843_RS09235
uniprot id: W5Y2S2
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

1224164:B843 RS07580
gene id: 1224164:B843_RS07580
uniprot id: W5Y0Z0
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS05030
gene id: 1224164:B843_RS05030
uniprot id: W5Y0F1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS11185
gene id: 1224164:B843_RS11185
uniprot id: W5Y3V1
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

1224164:B843 RS01225
gene id: 1224164:B843_RS01225
uniprot id: W5XY60
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

1224164:B843 RS09660
gene id: 1224164:B843_RS09660
uniprot id: W5Y1Y6
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

1224164:B843 RS06555
gene id: 1224164:B843_RS06555
uniprot id: W5Y0B6
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

1224164:B843 RS09065
gene id: 1224164:B843_RS09065
uniprot id: W5Y2S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1224164:B843 RS09145
gene id: 1224164:B843_RS09145
uniprot id: W5Y1Q3
names: Cofactor
names: Similarity
messages: Belongs to the class-II DAHP synthase family.
messages: Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.

1224164:B843 RS09650
gene id: 1224164:B843_RS09650
uniprot id: W5Y308
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1224164:B843 RS06615
gene id: 1224164:B843_RS06615
uniprot id: W5Y863
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1224164:B843 RS06510
gene id: 1224164:B843_RS06510
uniprot id: W5Y1B4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1224164:B843 RS08340
gene id: 1224164:B843_RS08340
uniprot id: W5Y2C1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1224164:B843 RS01460
gene id: 1224164:B843_RS01460
uniprot id: W5XXD2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1224164:B843 RS04765
gene id: 1224164:B843_RS04765
uniprot id: W5Y0A9
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1224164:B843 RS12405
gene id: 1224164:B843_RS12405
uniprot id: W5Y4J1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1224164:B843 RS09115
gene id: 1224164:B843_RS09115
uniprot id: W5Y2T4
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1224164:B843 RS12895
gene id: 1224164:B843_RS12895
uniprot id: W5Y4W4
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS09960
gene id: 1224164:B843_RS09960
uniprot id: W5Y2D6
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS02465
gene id: 1224164:B843_RS02465
uniprot id: W5XY09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1224164:B843 RS02295
gene id: 1224164:B843_RS02295
uniprot id: W5XY15
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

1224164:B843 RS07535
gene id: 1224164:B843_RS07535
uniprot id: W5Y118
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1224164:B843 RS13030
gene id: 1224164:B843_RS13030
uniprot id: W5Y3Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

1224164:B843 RS02415
gene id: 1224164:B843_RS02415
uniprot id: W5XXZ9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1224164:B843 RS05855
gene id: 1224164:B843_RS05855
uniprot id: W5Y7S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1224164:B843 RS08490
gene id: 1224164:B843_RS08490
uniprot id: W5Y2E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

1224164:B843 RS06915
gene id: 1224164:B843_RS06915
uniprot id: W5Y1E2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

1224164:B843 RS07525
gene id: 1224164:B843_RS07525
uniprot id: W5Y1Y8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

1224164:B843 RS06035
gene id: 1224164:B843_RS06035
uniprot id: W5Y0X5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS13085
gene id: 1224164:B843_RS13085
uniprot id: W5Y426
names: Similarity
messages: Belongs to the ParB family.

1224164:B843 RS10510
gene id: 1224164:B843_RS10510
uniprot id: W5Y2J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

1224164:B843 RS07855
gene id: 1224164:B843_RS07855
uniprot id: W5Y247
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.
messages: Cell membrane
messages: Contains a di-nuclear catalytic Mg(2+) center.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1224164:B843 RS02125
gene id: 1224164:B843_RS02125
uniprot id: W5Y5N7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1224164:B843 RS05620
gene id: 1224164:B843_RS05620
uniprot id: W5XZZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

1224164:B843 RS12400
gene id: 1224164:B843_RS12400
uniprot id: W5YBB1
names: Similarity
messages: Belongs to the catalase family.

1224164:B843 RS11865
gene id: 1224164:B843_RS11865
uniprot id: W5Y390
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1224164:B843 RS03510
gene id: 1224164:B843_RS03510
uniprot id: W5XYK4
names: Similarity
messages: Belongs to the peptidase S14 family.

1224164:B843 RS05115
gene id: 1224164:B843_RS05115
uniprot id: W5XZL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1224164:B843 RS07830
gene id: 1224164:B843_RS07830
uniprot id: W5Y243
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

1224164:B843 RS01365
gene id: 1224164:B843_RS01365
uniprot id: W5XY99
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1224164:B843 RS08230
gene id: 1224164:B843_RS08230
uniprot id: W5Y926
names: Similarity
messages: Belongs to the YciI family.

1224164:B843 RS04450
gene id: 1224164:B843_RS04450
uniprot id: W5XZ98
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1224164:B843 RS01165
gene id: 1224164:B843_RS01165
uniprot id: W5XXE0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1224164:B843 RS11205
gene id: 1224164:B843_RS11205
uniprot id: W5Y3V5
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1224164:B843 RS08645
gene id: 1224164:B843_RS08645
uniprot id: W5Y1H6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1224164:B843 RS00560
gene id: 1224164:B843_RS00560
uniprot id: W5XWW8
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1224164:B843 RS10115
gene id: 1224164:B843_RS10115
uniprot id: W5YA48
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1224164:B843 RS12890
gene id: 1224164:B843_RS12890
uniprot id: W5YBM4
names: Similarity
messages: Belongs to the UPF0371 family.

1224164:B843 RS13340
gene id: 1224164:B843_RS13340
uniprot id: W5Y4T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS11215
gene id: 1224164:B843_RS11215
uniprot id: W5Y2X0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS09175
gene id: 1224164:B843_RS09175
uniprot id: W5Y1V6
names: Similarity
messages: Belongs to the peptidase C40 family.

1224164:B843 RS11150
gene id: 1224164:B843_RS11150
uniprot id: W5YAL6
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS05660
gene id: 1224164:B843_RS05660
uniprot id: W5Y0V7
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

1224164:B843 RS07150
gene id: 1224164:B843_RS07150
uniprot id: W5Y0M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1224164:B843 RS08720
gene id: 1224164:B843_RS08720
uniprot id: W5Y1J1
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1224164:B843 RS02545
gene id: 1224164:B843_RS02545
uniprot id: W5XYA1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1224164:B843 RS05775
gene id: 1224164:B843_RS05775
uniprot id: W5Y024
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

1224164:B843 RS11260
gene id: 1224164:B843_RS11260
uniprot id: W5Y412
names: Function
names: Similarity
messages: Belongs to the IMPDH/GMPR family. GuaB1 subfamily.
messages: Involved in the purine-salvage pathway. Catalyzes the NADPH-dependent conversion of GMP to IMP.

1224164:B843 RS12635
gene id: 1224164:B843_RS12635
uniprot id: W5Y4W7
names: Similarity
messages: Belongs to the PspA/IM30 family.

1224164:B843 RS07720
gene id: 1224164:B843_RS07720
uniprot id: W5Y8W8
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS09420
gene id: 1224164:B843_RS09420
uniprot id: W5Y209
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1224164:B843 RS06060
gene id: 1224164:B843_RS06060
uniprot id: W5Y0Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224164:B843 RS07590
gene id: 1224164:B843_RS07590
uniprot id: W5Y8U9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

1224164:B843 RS05280
gene id: 1224164:B843_RS05280
uniprot id: W5Y0J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1224164:B843 RS10925
gene id: 1224164:B843_RS10925
uniprot id: W5Y3Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1224164:B843 RS06620
gene id: 1224164:B843_RS06620
uniprot id: W5Y188
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

1224164:B843 RS05940
gene id: 1224164:B843_RS05940
uniprot id: W5Y100
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1224164:B843 RS08850
gene id: 1224164:B843_RS08850
uniprot id: W5Y1L1
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1224164:B843 RS12935
gene id: 1224164:B843_RS12935
uniprot id: W5Y3Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1224164:B843 RS04830
gene id: 1224164:B843_RS04830
uniprot id: W5Y789
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1224164:B843 RS08185
gene id: 1224164:B843_RS08185
uniprot id: W5Y260
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1224164:B843 RS10695
gene id: 1224164:B843_RS10695
uniprot id: W5Y2S3
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1224164:B843 RS07090
gene id: 1224164:B843_RS07090
uniprot id: W5Y1H7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic ubiquitin-like protein family.
messages: Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.
messages: Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
messages: Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.
messages: The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.

1224164:B843 RS02645
gene id: 1224164:B843_RS02645
uniprot id: W5XYB7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1224164:B843 RS11095
gene id: 1224164:B843_RS11095
uniprot id: W5Y2X8
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS04805
gene id: 1224164:B843_RS04805
uniprot id: W5Y770
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1224164:B843 RS06545
gene id: 1224164:B843_RS06545
uniprot id: W5Y0D8
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

1224164:B843 RS09680
gene id: 1224164:B843_RS09680
uniprot id: W5Y352
names: Similarity
messages: Belongs to the disproportionating enzyme family.

1224164:B843 RS02660
gene id: 1224164:B843_RS02660
uniprot id: W5XZ53
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1224164:B843 RS07380
gene id: 1224164:B843_RS07380
uniprot id: W5Y0R9
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1224164:B843 RS07035
gene id: 1224164:B843_RS07035
uniprot id: W5Y8F7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1224164:B843 RS11145
gene id: 1224164:B843_RS11145
uniprot id: W5Y2Y5
names: Similarity
messages: Belongs to the TPP enzyme family.

1224164:B843 RS09780
gene id: 1224164:B843_RS09780
uniprot id: W5Y376
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

1224164:B843 RS07315
gene id: 1224164:B843_RS07315
uniprot id: W5Y8L9
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

1224164:B843 RS07255
gene id: 1224164:B843_RS07255
uniprot id: W5Y0P3
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1224164:B843 RS11580
gene id: 1224164:B843_RS11580
uniprot id: W5Y337
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

1224164:B843 RS07375
gene id: 1224164:B843_RS07375
uniprot id: W5Y1R7
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

1224164:B843 RS08530
gene id: 1224164:B843_RS08530
uniprot id: W5Y974
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1224164:B843 RS12155
gene id: 1224164:B843_RS12155
uniprot id: W5YB53
names: Similarity
messages: Belongs to the AccD/PCCB family.

1224164:B843 RS12250
gene id: 1224164:B843_RS12250
uniprot id: W5Y3I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

1224164:B843 RS10295
gene id: 1224164:B843_RS10295
uniprot id: W5Y2F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224164:B843 RS05875
gene id: 1224164:B843_RS05875
uniprot id: W5Y041
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1224164:B843 RS06110
gene id: 1224164:B843_RS06110
uniprot id: W5Y0Y9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS06165
gene id: 1224164:B843_RS06165
uniprot id: W5Y148
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

1224164:B843 RS05120
gene id: 1224164:B843_RS05120
uniprot id: W5XZS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1224164:B843 RS05290
gene id: 1224164:B843_RS05290
uniprot id: W5XZN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

1224164:B843 RS03170
gene id: 1224164:B843_RS03170
uniprot id: W5XYL2
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

1224164:B843 RS03790
gene id: 1224164:B843_RS03790
uniprot id: W5XYR3
names: Function
names: Similarity
messages: Belongs to the cyanase family.
messages: Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.

1224164:B843 RS05900
gene id: 1224164:B843_RS05900
uniprot id: W5Y045
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

1224164:B843 RS02425
gene id: 1224164:B843_RS02425
uniprot id: W5Y5X7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1224164:B843 RS02120
gene id: 1224164:B843_RS02120
uniprot id: W5XXX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1224164:B843 RS06815
gene id: 1224164:B843_RS06815
uniprot id: W5Y1H4
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS02185
gene id: 1224164:B843_RS02185
uniprot id: W5XYS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1224164:B843 RS05650
gene id: 1224164:B843_RS05650
uniprot id: W5Y7N8
names: Function
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.

1224164:B843 RS06955
gene id: 1224164:B843_RS06955
uniprot id: W5Y0L9
names: Similarity
messages: Belongs to the DyP-type peroxidase family.

1224164:B843 RS11330
gene id: 1224164:B843_RS11330
uniprot id: W5Y427
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

1224164:B843 RS06160
gene id: 1224164:B843_RS06160
uniprot id: W5Y0Z9
names: Subunit
messages: Homodimer.

1224164:B843 RS02895
gene id: 1224164:B843_RS02895
uniprot id: W5XYG3
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1224164:B843 RS09270
gene id: 1224164:B843_RS09270
uniprot id: W5Y1S2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1224164:B843 RS04170
gene id: 1224164:B843_RS04170
uniprot id: W5XZZ4
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1224164:B843 RS11465
gene id: 1224164:B843_RS11465
uniprot id: W5YAT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

1224164:B843 RS09990
gene id: 1224164:B843_RS09990
uniprot id: W5YA25
names: Similarity
messages: Belongs to the pirin family.

1224164:B843 RS08580
gene id: 1224164:B843_RS08580
uniprot id: W5Y984
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

1224164:B843 RS12445
gene id: 1224164:B843_RS12445
uniprot id: W5Y3M9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

1224164:B843 RS02280
gene id: 1224164:B843_RS02280
uniprot id: W5XYT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

1224164:B843 RS07040
gene id: 1224164:B843_RS07040
uniprot id: W5Y1G7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1224164:B843 RS06440
gene id: 1224164:B843_RS06440
uniprot id: W5Y092
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

1224164:B843 RS04550
gene id: 1224164:B843_RS04550
uniprot id: W5XZC1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1224164:B843 RS10150
gene id: 1224164:B843_RS10150
uniprot id: W5Y3I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1224164:B843 RS07815
gene id: 1224164:B843_RS07815
uniprot id: W5Y168
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1224164:B843 RS09165
gene id: 1224164:B843_RS09165
uniprot id: W5Y2U5
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1224164:B843 RS03255
gene id: 1224164:B843_RS03255
uniprot id: W5XZB9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1224164:B843 RS06640
gene id: 1224164:B843_RS06640
uniprot id: W5Y868
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1224164:B843 RS13000
gene id: 1224164:B843_RS13000
uniprot id: W5Y529
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS12090
gene id: 1224164:B843_RS12090
uniprot id: W5Y4I0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

1224164:B843 RS01335
gene id: 1224164:B843_RS01335
uniprot id: W5XY77
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1224164:B843 RS02820
gene id: 1224164:B843_RS02820
uniprot id: W5XYE7
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1224164:B843 RS07530
gene id: 1224164:B843_RS07530
uniprot id: W5Y0Y1
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1224164:B843 RS00345
gene id: 1224164:B843_RS00345
uniprot id: W5Y4Q7
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS11965
gene id: 1224164:B843_RS11965
uniprot id: W5Y3A9
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

1224164:B843 RS08450
gene id: 1224164:B843_RS08450
uniprot id: W5Y1I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1224164:B843 RS01720
gene id: 1224164:B843_RS01720
uniprot id: W5XYH8
names: Similarity
messages: Belongs to the peptidase M1 family.

1224164:B843 RS11925
gene id: 1224164:B843_RS11925
uniprot id: W5YB14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS02080
gene id: 1224164:B843_RS02080
uniprot id: W5XYP0
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1224164:B843 RS02470
gene id: 1224164:B843_RS02470
uniprot id: W5XY86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1224164:B843 RS08210
gene id: 1224164:B843_RS08210
uniprot id: W5Y264
names: Similarity
messages: Belongs to the PspA/IM30 family.

1224164:B843 RS12255
gene id: 1224164:B843_RS12255
uniprot id: W5YB76
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS12810
gene id: 1224164:B843_RS12810
uniprot id: W5Y4U4
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS05580
gene id: 1224164:B843_RS05580
uniprot id: W5Y7M4
names: Similarity
messages: Belongs to the HupF/HypC family.

1224164:B843 RS05605
gene id: 1224164:B843_RS05605
uniprot id: W5Y7M8
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

1224164:B843 RS00235
gene id: 1224164:B843_RS00235
uniprot id: W5XWX8
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS09265
gene id: 1224164:B843_RS09265
uniprot id: W5Y2W7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1224164:B843 RS11175
gene id: 1224164:B843_RS11175
uniprot id: W5Y2Y9
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

1224164:B843 RS05230
gene id: 1224164:B843_RS05230
uniprot id: W5Y0I6
names: Similarity
messages: Belongs to the ArsC family.

1224164:B843 RS02575
gene id: 1224164:B843_RS02575
uniprot id: W5Y602
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1224164:B843 RS07215
gene id: 1224164:B843_RS07215
uniprot id: W5Y1K1
names: Similarity
messages: Belongs to the UPF0098 family.

1224164:B843 RS11080
gene id: 1224164:B843_RS11080
uniprot id: W5Y3T0
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

1224164:B843 RS00145
gene id: 1224164:B843_RS00145
uniprot id: W5Y4M4
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS05845
gene id: 1224164:B843_RS05845
uniprot id: W5XZZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1224164:B843 RS13990
gene id: 1224164:B843_RS13990
uniprot id: W5XZ86
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS11590
gene id: 1224164:B843_RS11590
uniprot id: W5YAV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

1224164:B843 RS04325
gene id: 1224164:B843_RS04325
uniprot id: W5XZ69
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

1224164:B843 RS01875
gene id: 1224164:B843_RS01875
uniprot id: W5XXS7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1224164:B843 RS05140
gene id: 1224164:B843_RS05140
uniprot id: W5XZL5
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1224164:B843 RS09300
gene id: 1224164:B843_RS09300
uniprot id: W5Y1Y4
names: Similarity
messages: Belongs to the glutamine synthetase family.

1224164:B843 RS11060
gene id: 1224164:B843_RS11060
uniprot id: W5Y3X3
names: Similarity
messages: Belongs to the glutathione peroxidase family.

1224164:B843 RS12440
gene id: 1224164:B843_RS12440
uniprot id: W5Y3L5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Homodimer.

1224164:B843 RS06045
gene id: 1224164:B843_RS06045
uniprot id: W5Y032
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1224164:B843 RS04045
gene id: 1224164:B843_RS04045
uniprot id: W5XZR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

1224164:B843 RS03940
gene id: 1224164:B843_RS03940
uniprot id: W5XZP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

1224164:B843 RS12875
gene id: 1224164:B843_RS12875
uniprot id: W5Y510
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS11325
gene id: 1224164:B843_RS11325
uniprot id: W5Y3Y1
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

1224164:B843 RS10815
gene id: 1224164:B843_RS10815
uniprot id: W5Y2T6
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1224164:B843 RS03865
gene id: 1224164:B843_RS03865
uniprot id: W5XZM4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1224164:B843 RS01245
gene id: 1224164:B843_RS01245
uniprot id: W5Y555
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

1224164:B843 RS07430
gene id: 1224164:B843_RS07430
uniprot id: W5Y0W5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1224164:B843 RS08035
gene id: 1224164:B843_RS08035
uniprot id: W5Y234
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1224164:B843 RS07200
gene id: 1224164:B843_RS07200
uniprot id: W5Y0N1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

1224164:B843 RS00700
gene id: 1224164:B843_RS00700
uniprot id: W5XXX2
names: Similarity
messages: Belongs to the EfeM/EfeO family.

1224164:B843 RS04710
gene id: 1224164:B843_RS04710
uniprot id: W5Y061
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

1224164:B843 RS08615
gene id: 1224164:B843_RS08615
uniprot id: W5Y2H3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1224164:B843 RS01705
gene id: 1224164:B843_RS01705
uniprot id: W5XXN7
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

1224164:B843 RS08205
gene id: 1224164:B843_RS08205
uniprot id: W5Y922
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS10715
gene id: 1224164:B843_RS10715
uniprot id: W5Y2N0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1224164:B843 RS01430
gene id: 1224164:B843_RS01430
uniprot id: W5XXC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS06130
gene id: 1224164:B843_RS06130
uniprot id: W5Y7X5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1224164:B843 RS06705
gene id: 1224164:B843_RS06705
uniprot id: W5Y881
names: Similarity
messages: Belongs to the TlyA family.

1224164:B843 RS09555
gene id: 1224164:B843_RS09555
uniprot id: W5Y1W5
names: Similarity
messages: Belongs to the barstar family.

1224164:B843 RS03085
gene id: 1224164:B843_RS03085
uniprot id: W5XZD1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1224164:B843 RS00780
gene id: 1224164:B843_RS00780
uniprot id: W5XXZ0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

1224164:B843 RS04505
gene id: 1224164:B843_RS04505
uniprot id: W5Y702
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

1224164:B843 RS03275
gene id: 1224164:B843_RS03275
uniprot id: W5Y6A8
names: Similarity
messages: Belongs to the peptidase S16 family.

1224164:B843 RS07800
gene id: 1224164:B843_RS07800
uniprot id: W5Y1Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1224164:B843 RS08310
gene id: 1224164:B843_RS08310
uniprot id: W5Y279
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1224164:B843 RS06795
gene id: 1224164:B843_RS06795
uniprot id: W5Y0F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1224164:B843 RS07065
gene id: 1224164:B843_RS07065
uniprot id: W5Y1H3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1224164:B843 RS06355
gene id: 1224164:B843_RS06355
uniprot id: W5Y183
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.

1224164:B843 RS11775
gene id: 1224164:B843_RS11775
uniprot id: W5YAY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1224164:B843 RS05070
gene id: 1224164:B843_RS05070
uniprot id: W5XZR2
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS09295
gene id: 1224164:B843_RS09295
uniprot id: W5Y1S5
names: Subcellular Location Annotation
messages: Membrane

1224164:B843 RS05975
gene id: 1224164:B843_RS05975
uniprot id: W5Y057
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224164:B843 RS03885
gene id: 1224164:B843_RS03885
uniprot id: W5Y6L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1224164:B843 RS08590
gene id: 1224164:B843_RS08590
uniprot id: W5Y2G7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1224164:B843 RS02995
gene id: 1224164:B843_RS02995
uniprot id: W5XYI1
names: Similarity
messages: Belongs to the CsoR family.

1224164:B843 RS05780
gene id: 1224164:B843_RS05780
uniprot id: W5Y7Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1224164:B843 RS11475
gene id: 1224164:B843_RS11475
uniprot id: W5Y457
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

1224164:B843 RS05320
gene id: 1224164:B843_RS05320
uniprot id: W5XZP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.

1224164:B843 RS05155
gene id: 1224164:B843_RS05155
uniprot id: W5Y0H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1224164:B843 RS08790
gene id: 1224164:B843_RS08790
uniprot id: W5Y2G5
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

1224164:B843 RS10800
gene id: 1224164:B843_RS10800
uniprot id: W5Y3P1
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

1224164:B843 RS07975
gene id: 1224164:B843_RS07975
uniprot id: W5Y195
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.