1224162:B840 RS03875
gene id: 1224162:B840_RS03875
uniprot id: A0A0B6TQ87
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS06230
gene id: 1224162:B840_RS06230
uniprot id: A0A0B6TTI4
names: Similarity
messages: Belongs to the peptidase M18 family.

1224162:B840 RS05250
gene id: 1224162:B840_RS05250
uniprot id: A0A0B6TFA6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS00305
gene id: 1224162:B840_RS00305
uniprot id: A0A0B6TQ19
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS02185
gene id: 1224162:B840_RS02185
uniprot id: A0A0B6TDR7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

1224162:B840 RS07695
gene id: 1224162:B840_RS07695
uniprot id: A0A0B6TMI4
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

1224162:B840 RS12620
gene id: 1224162:B840_RS12620
uniprot id: A0A0B6TX52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1224162:B840 RS05075
gene id: 1224162:B840_RS05075
uniprot id: A0A0B6TF69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

1224162:B840 RS12155
gene id: 1224162:B840_RS12155
uniprot id: A0A0B6TQ46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1224162:B840 RS08465
gene id: 1224162:B840_RS08465
uniprot id: A0A0B6TSU3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1224162:B840 RS00625
gene id: 1224162:B840_RS00625
uniprot id: A0A0B6TII0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1224162:B840 RS05810
gene id: 1224162:B840_RS05810
uniprot id: A0A0B6TT81
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS06015
gene id: 1224162:B840_RS06015
uniprot id: A0A0B6TTC8
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS09750
gene id: 1224162:B840_RS09750
uniprot id: A0A0B6TXW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

1224162:B840 RS02030
gene id: 1224162:B840_RS02030
uniprot id: A0A0B6TTF6
names: Similarity
messages: Belongs to the peptidase S8 family.

1224162:B840 RS07395
gene id: 1224162:B840_RS07395
uniprot id: A0A0B6TGI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1224162:B840 RS07380
gene id: 1224162:B840_RS07380
uniprot id: A0A0B6TS35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS02290
gene id: 1224162:B840_RS02290
uniprot id: A0A0B6TDT5
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS07225
gene id: 1224162:B840_RS07225
uniprot id: A0A0B6TM83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1224162:B840 RS11115
gene id: 1224162:B840_RS11115
uniprot id: A0A0B6TIQ6
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

1224162:B840 RS11895
gene id: 1224162:B840_RS11895
uniprot id: A0A0B6TWN0
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS09420
gene id: 1224162:B840_RS09420
uniprot id: A0A0B6TTC5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

1224162:B840 RS08700
gene id: 1224162:B840_RS08700
uniprot id: A0A0B6THF8
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

1224162:B840 RS04900
gene id: 1224162:B840_RS04900
uniprot id: A0A0B6TF30
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS08095
gene id: 1224162:B840_RS08095
uniprot id: A0A0B6TSJ9
names: Similarity
messages: Belongs to the HSP15 family.

1224162:B840 RS11255
gene id: 1224162:B840_RS11255
uniprot id: A0A0B6TWD6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

1224162:B840 RS11860
gene id: 1224162:B840_RS11860
uniprot id: A0A0B6TJ50
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS01940
gene id: 1224162:B840_RS01940
uniprot id: A0A0B6TJA9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1224162:B840 RS02445
gene id: 1224162:B840_RS02445
uniprot id: A0A0B6TDW3
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS10415
gene id: 1224162:B840_RS10415
uniprot id: A0A0B6TY87
names: Caution
names: Similarity
messages: Belongs to the nitrobindin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lacks the conserved His residue that binds heme iron in the nitrobindin family.

1224162:B840 RS01610
gene id: 1224162:B840_RS01610
uniprot id: A0A0B6TT86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

1224162:B840 RS00500
gene id: 1224162:B840_RS00500
uniprot id: A0A0B6TIE1
names: Function
names: Similarity
messages: Belongs to the AMP nucleosidase family.
messages: Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.

1224162:B840 RS02910
gene id: 1224162:B840_RS02910
uniprot id: A0A0B6TJT9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1224162:B840 RS04475
gene id: 1224162:B840_RS04475
uniprot id: A0A0B6TUV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.

1224162:B840 RS02585
gene id: 1224162:B840_RS02585
uniprot id: A0A0B6TRD8
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1224162:B840 RS05275
gene id: 1224162:B840_RS05275
uniprot id: A0A0B6TFB2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS07390
gene id: 1224162:B840_RS07390
uniprot id: A0A0B6TWG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

1224162:B840 RS01790
gene id: 1224162:B840_RS01790
uniprot id: A0A0B6TJ86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1224162:B840 RS11310
gene id: 1224162:B840_RS11310
uniprot id: A0A0B6TIV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

1224162:B840 RS11870
gene id: 1224162:B840_RS11870
uniprot id: A0A0B6TUM9
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS10900
gene id: 1224162:B840_RS10900
uniprot id: A0A0B6TU60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS09600
gene id: 1224162:B840_RS09600
uniprot id: A0A0B6TVB0
names: Similarity
messages: Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.

1224162:B840 RS00375
gene id: 1224162:B840_RS00375
uniprot id: A0A0B6TN67
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS00760
gene id: 1224162:B840_RS00760
uniprot id: A0A0B6TQB9
names: Similarity
messages: Belongs to the glutamate synthase family.

1224162:B840 RS06130
gene id: 1224162:B840_RS06130
uniprot id: A0A0B6TTH0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS12205
gene id: 1224162:B840_RS12205
uniprot id: A0A0B6TQ52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

1224162:B840 RS03815
gene id: 1224162:B840_RS03815
uniprot id: A0A0B6TEL1
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS01045
gene id: 1224162:B840_RS01045
uniprot id: A0A0B6TQL3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1224162:B840 RS01370
gene id: 1224162:B840_RS01370
uniprot id: A0A0B6TT44
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

1224162:B840 RS03970
gene id: 1224162:B840_RS03970
uniprot id: A0A0B6TKF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1224162:B840 RS01155
gene id: 1224162:B840_RS01155
uniprot id: A0A0B6TIY6
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS06840
gene id: 1224162:B840_RS06840
uniprot id: A0A0B6TW69
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1224162:B840 RS05690
gene id: 1224162:B840_RS05690
uniprot id: A0A0B6TLE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

1224162:B840 RS06560
gene id: 1224162:B840_RS06560
uniprot id: A0A0B6TTM9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS01930
gene id: 1224162:B840_RS01930
uniprot id: A0A0B6TTE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1224162:B840 RS07935
gene id: 1224162:B840_RS07935
uniprot id: A0A0B6TWS8
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1224162:B840 RS06685
gene id: 1224162:B840_RS06685
uniprot id: A0A0B6TTP6
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

1224162:B840 RS10825
gene id: 1224162:B840_RS10825
uniprot id: A0A0B6TPD8
names: Similarity
messages: Belongs to the peptidase S13 family.

1224162:B840 RS04000
gene id: 1224162:B840_RS04000
uniprot id: A0A0B6TQA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

1224162:B840 RS10590
gene id: 1224162:B840_RS10590
uniprot id: A0A0B6TYD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diaminopimelate dehydrogenase family.
messages: Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate.
messages: Homodimer.

1224162:B840 RS01315
gene id: 1224162:B840_RS01315
uniprot id: A0A0B6TNT8
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

1224162:B840 RS00105
gene id: 1224162:B840_RS00105
uniprot id: A0A0B6TN14
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

1224162:B840 RS12575
gene id: 1224162:B840_RS12575
uniprot id: A0A0B6TZL5
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS05510
gene id: 1224162:B840_RS05510
uniprot id: A0A0B6TVF8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1224162:B840 RS05765
gene id: 1224162:B840_RS05765
uniprot id: A0A0B6TLG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1224162:B840 RS03365
gene id: 1224162:B840_RS03365
uniprot id: A0A0B6TRW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

1224162:B840 RS05695
gene id: 1224162:B840_RS05695
uniprot id: A0A0B6TR66
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1224162:B840 RS09470
gene id: 1224162:B840_RS09470
uniprot id: A0A0B6TTD2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1224162:B840 RS07140
gene id: 1224162:B840_RS07140
uniprot id: A0A0B6TWB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1224162:B840 RS06595
gene id: 1224162:B840_RS06595
uniprot id: A0A0B6TG39
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1224162:B840 RS09135
gene id: 1224162:B840_RS09135
uniprot id: A0A0B6TNG6
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS11745
gene id: 1224162:B840_RS11745
uniprot id: A0A0B6TWK9
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS11790
gene id: 1224162:B840_RS11790
uniprot id: A0A0B6TZ41
names: Similarity
messages: Belongs to the PspA/IM30 family.

1224162:B840 RS00665
gene id: 1224162:B840_RS00665
uniprot id: A0A0B6TSM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS09790
gene id: 1224162:B840_RS09790
uniprot id: A0A0B6TTI2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1224162:B840 RS00810
gene id: 1224162:B840_RS00810
uniprot id: A0A0B6TCY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1224162:B840 RS00825
gene id: 1224162:B840_RS00825
uniprot id: A0A0B6TQE1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1224162:B840 RS00865
gene id: 1224162:B840_RS00865
uniprot id: A0A0B6TCZ9
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1224162:B840 RS03535
gene id: 1224162:B840_RS03535
uniprot id: A0A0B6TEH3
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

1224162:B840 RS06460
gene id: 1224162:B840_RS06460
uniprot id: A0A0B6TTL7
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1224162:B840 RS10465
gene id: 1224162:B840_RS10465
uniprot id: A0A0B6TYA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

1224162:B840 RS10895
gene id: 1224162:B840_RS10895
uniprot id: A0A0B6TPF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS02440
gene id: 1224162:B840_RS02440
uniprot id: A0A0B6TTM8
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS09080
gene id: 1224162:B840_RS09080
uniprot id: A0A0B6THM1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm

1224162:B840 RS12240
gene id: 1224162:B840_RS12240
uniprot id: A0A0B6TWT6
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1224162:B840 RS07590
gene id: 1224162:B840_RS07590
uniprot id: A0A0B6TGM6
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS05285
gene id: 1224162:B840_RS05285
uniprot id: A0A0B6TQY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224162:B840 RS07840
gene id: 1224162:B840_RS07840
uniprot id: A0A0B6TGS7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1224162:B840 RS10890
gene id: 1224162:B840_RS10890
uniprot id: A0A0B6TIJ9
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS07490
gene id: 1224162:B840_RS07490
uniprot id: A0A0B6TWI5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1224162:B840 RS07985
gene id: 1224162:B840_RS07985
uniprot id: A0A0B6TWU1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

1224162:B840 RS01990
gene id: 1224162:B840_RS01990
uniprot id: A0A0B6TJC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1224162:B840 RS08205
gene id: 1224162:B840_RS08205
uniprot id: A0A0B6TX04
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1224162:B840 RS08540
gene id: 1224162:B840_RS08540
uniprot id: A0A0B6TUT6
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS01070
gene id: 1224162:B840_RS01070
uniprot id: A0A0B6TQL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS09745
gene id: 1224162:B840_RS09745
uniprot id: A0A0B6TVD4
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Catalyzes the reversible reductive amination of pyruvate to L-alanine.

1224162:B840 RS10080
gene id: 1224162:B840_RS10080
uniprot id: A0A0B6TNX6
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

1224162:B840 RS13665
gene id: 1224162:B840_RS13665
uniprot id: A0A0B6TDQ4
names: Similarity
messages: Belongs to the cytochrome P450 family.

1224162:B840 RS12010
gene id: 1224162:B840_RS12010
uniprot id: A0A0B6TQ25
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1224162:B840 RS07760
gene id: 1224162:B840_RS07760
uniprot id: A0A0B6TWN8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1224162:B840 RS03975
gene id: 1224162:B840_RS03975
uniprot id: A0A0B6TQA3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

1224162:B840 RS09030
gene id: 1224162:B840_RS09030
uniprot id: A0A0B6TXK7
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

1224162:B840 RS08115
gene id: 1224162:B840_RS08115
uniprot id: A0A0B6TMT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

1224162:B840 RS02820
gene id: 1224162:B840_RS02820
uniprot id: A0A0B6TE31
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1224162:B840 RS08435
gene id: 1224162:B840_RS08435
uniprot id: A0A0B6TN17
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1224162:B840 RS12230
gene id: 1224162:B840_RS12230
uniprot id: A0A0B6TQ56
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS12430
gene id: 1224162:B840_RS12430
uniprot id: A0A0B6TQC5
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

1224162:B840 RS04690
gene id: 1224162:B840_RS04690
uniprot id: A0A0B6TSJ8
names: Similarity
messages: Belongs to the FAD-binding monooxygenase family.

1224162:B840 RS02010
gene id: 1224162:B840_RS02010
uniprot id: A0A0B6TDN4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS07235
gene id: 1224162:B840_RS07235
uniprot id: A0A0B6TTY4
names: Function
names: Similarity
names: Subunit
messages: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
messages: Belongs to the AhpD family.
messages: Homotrimer.

1224162:B840 RS08215
gene id: 1224162:B840_RS08215
uniprot id: A0A0B6TMW5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1224162:B840 RS01800
gene id: 1224162:B840_RS01800
uniprot id: A0A0B6TQX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1224162:B840 RS05195
gene id: 1224162:B840_RS05195
uniprot id: A0A0B6TV90
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS12555
gene id: 1224162:B840_RS12555
uniprot id: A0A0B6TJL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

1224162:B840 RS11725
gene id: 1224162:B840_RS11725
uniprot id: A0A0B6TZ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS05230
gene id: 1224162:B840_RS05230
uniprot id: A0A0B6TL34
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1224162:B840 RS03680
gene id: 1224162:B840_RS03680
uniprot id: A0A0B6TEJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1224162:B840 RS03385
gene id: 1224162:B840_RS03385
uniprot id: A0A0B6TQ01
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

1224162:B840 RS05915
gene id: 1224162:B840_RS05915
uniprot id: A0A0B6TVQ4
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS09055
gene id: 1224162:B840_RS09055
uniprot id: A0A0B6TXL0
names: Similarity
messages: Belongs to the disproportionating enzyme family.

1224162:B840 RS04705
gene id: 1224162:B840_RS04705
uniprot id: A0A0B6TKS4
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1224162:B840 RS03370
gene id: 1224162:B840_RS03370
uniprot id: A0A0B6TU99
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1224162:B840 RS11265
gene id: 1224162:B840_RS11265
uniprot id: A0A0B6TIU3
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

1224162:B840 RS08005
gene id: 1224162:B840_RS08005
uniprot id: A0A0B6TUD4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1224162:B840 RS02195
gene id: 1224162:B840_RS02195
uniprot id: A0A0B6TP90
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1224162:B840 RS09220
gene id: 1224162:B840_RS09220
uniprot id: A0A0B6TT92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Belongs to the sulfur carrier protein TusA family.
messages: Cell inner membrane
messages: Membrane

1224162:B840 RS06690
gene id: 1224162:B840_RS06690
uniprot id: A0A0B6TW46
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

1224162:B840 RS01885
gene id: 1224162:B840_RS01885
uniprot id: A0A0B6TDL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1224162:B840 RS09485
gene id: 1224162:B840_RS09485
uniprot id: A0A0B6TNM2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1224162:B840 RS09115
gene id: 1224162:B840_RS09115
uniprot id: A0A0B6TT77
names: Similarity
names: Subunit
messages: Belongs to the aminoglycoside phosphotransferase family.
messages: Monomer.

1224162:B840 RS06960
gene id: 1224162:B840_RS06960
uniprot id: A0A0B6TTU1
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS02270
gene id: 1224162:B840_RS02270
uniprot id: A0A0B6TJH4
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1224162:B840 RS00995
gene id: 1224162:B840_RS00995
uniprot id: A0A0B6TIT3
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS02055
gene id: 1224162:B840_RS02055
uniprot id: A0A0B6TTG0
names: Similarity
messages: Belongs to the WXG100 family.

1224162:B840 RS03135
gene id: 1224162:B840_RS03135
uniprot id: A0A0B6TU38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

1224162:B840 RS02395
gene id: 1224162:B840_RS02395
uniprot id: A0A0B6TDV3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1224162:B840 RS02405
gene id: 1224162:B840_RS02405
uniprot id: A0A0B6TPC8
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1224162:B840 RS03625
gene id: 1224162:B840_RS03625
uniprot id: A0A0B6TS38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS06885
gene id: 1224162:B840_RS06885
uniprot id: A0A0B6TTS9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1224162:B840 RS08305
gene id: 1224162:B840_RS08305
uniprot id: A0A0B6TX28
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1224162:B840 RS09025
gene id: 1224162:B840_RS09025
uniprot id: A0A0B6TV25
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1224162:B840 RS05730
gene id: 1224162:B840_RS05730
uniprot id: A0A0B6TVL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1224162:B840 RS06905
gene id: 1224162:B840_RS06905
uniprot id: A0A0B6TRV4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1224162:B840 RS11840
gene id: 1224162:B840_RS11840
uniprot id: A0A0B6TJ45
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

1224162:B840 RS00735
gene id: 1224162:B840_RS00735
uniprot id: A0A0B6TQB2
names: Similarity
messages: Belongs to the peptidase M13 family.

1224162:B840 RS03170
gene id: 1224162:B840_RS03170
uniprot id: A0A0B6TJZ3
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

1224162:B840 RS05670
gene id: 1224162:B840_RS05670
uniprot id: A0A0B6TLE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1224162:B840 RS01505
gene id: 1224162:B840_RS01505
uniprot id: A0A0B6TQT0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1224162:B840 RS03610
gene id: 1224162:B840_RS03610
uniprot id: A0A0B6TEI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Homotrimer.

1224162:B840 RS06910
gene id: 1224162:B840_RS06910
uniprot id: A0A0B6TTT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1224162:B840 RS02170
gene id: 1224162:B840_RS02170
uniprot id: A0A0B6TP83
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1224162:B840 RS11160
gene id: 1224162:B840_RS11160
uniprot id: A0A0B6TYV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224162:B840 RS05290
gene id: 1224162:B840_RS05290
uniprot id: A0A0B6TSW1
names: Similarity
messages: Belongs to the CmpA/NrtA family.

1224162:B840 RS10475
gene id: 1224162:B840_RS10475
uniprot id: A0A0B6TP52
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1224162:B840 RS06565
gene id: 1224162:B840_RS06565
uniprot id: A0A0B6TW26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1224162:B840 RS11210
gene id: 1224162:B840_RS11210
uniprot id: A0A0B6TYW0
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1224162:B840 RS01870
gene id: 1224162:B840_RS01870
uniprot id: A0A0B6TP29
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1224162:B840 RS03375
gene id: 1224162:B840_RS03375
uniprot id: A0A0B6TEC2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1224162:B840 RS10170
gene id: 1224162:B840_RS10170
uniprot id: A0A0B6TY44
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1224162:B840 RS10755
gene id: 1224162:B840_RS10755
uniprot id: A0A0B6TU21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

1224162:B840 RS00005
gene id: 1224162:B840_RS00005
uniprot id: A0A0B6TS90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1224162:B840 RS03525
gene id: 1224162:B840_RS03525
uniprot id: A0A0B6TS04
names: Similarity
messages: Belongs to the peptidase C56 family.

1224162:B840 RS00925
gene id: 1224162:B840_RS00925
uniprot id: A0A0B6TSU2
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

1224162:B840 RS09370
gene id: 1224162:B840_RS09370
uniprot id: A0A0B6TTB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1224162:B840 RS01040
gene id: 1224162:B840_RS01040
uniprot id: A0A0B6TNQ3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS03580
gene id: 1224162:B840_RS03580
uniprot id: A0A0B6TUG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

1224162:B840 RS05880
gene id: 1224162:B840_RS05880
uniprot id: A0A0B6TRA8
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1224162:B840 RS10280
gene id: 1224162:B840_RS10280
uniprot id: A0A0B6TP16
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1224162:B840 RS04185
gene id: 1224162:B840_RS04185
uniprot id: A0A0B6TSB0
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1224162:B840 RS04325
gene id: 1224162:B840_RS04325
uniprot id: A0A0B6TSD2
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS03420
gene id: 1224162:B840_RS03420
uniprot id: A0A0B6TRX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

1224162:B840 RS11635
gene id: 1224162:B840_RS11635
uniprot id: A0A0B6TJ10
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1224162:B840 RS09455
gene id: 1224162:B840_RS09455
uniprot id: A0A0B6TXR8
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

1224162:B840 RS09300
gene id: 1224162:B840_RS09300
uniprot id: A0A0B6TV57
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS01730
gene id: 1224162:B840_RS01730
uniprot id: A0A0B6TTA3
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS01450
gene id: 1224162:B840_RS01450
uniprot id: A0A0B6TJ34
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1224162:B840 RS02495
gene id: 1224162:B840_RS02495
uniprot id: A0A0B6TDX3
names: Similarity
messages: Belongs to the PrpD family.

1224162:B840 RS09070
gene id: 1224162:B840_RS09070
uniprot id: A0A0B6TV32
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

1224162:B840 RS12770
gene id: 1224162:B840_RS12770
uniprot id: A0A0B6TJR7
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS04790
gene id: 1224162:B840_RS04790
uniprot id: A0A0B6TSL3
names: Similarity
names: Subunit
messages: Belongs to the muconolactone Delta-isomerase family.
messages: Homodecamer.

1224162:B840 RS01975
gene id: 1224162:B840_RS01975
uniprot id: A0A0B6TR10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1224162:B840 RS09230
gene id: 1224162:B840_RS09230
uniprot id: A0A0B6TXN3
names: Function
names: Similarity
messages: Belongs to the catalase family. HPII subfamily.
messages: Serves to protect cells from the toxic effects of hydrogen peroxide.

1224162:B840 RS09325
gene id: 1224162:B840_RS09325
uniprot id: A0A0B6TV61
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1224162:B840 RS00585
gene id: 1224162:B840_RS00585
uniprot id: A0A0B6TQ75
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

1224162:B840 RS06310
gene id: 1224162:B840_RS06310
uniprot id: A0A0B6TVZ0
names: Similarity
messages: Belongs to the UPF0098 family.

1224162:B840 RS02300
gene id: 1224162:B840_RS02300
uniprot id: A0A0B6TPB0
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS02505
gene id: 1224162:B840_RS02505
uniprot id: A0A0B6TPE7
names: Similarity
messages: Belongs to the citrate synthase family.

1224162:B840 RS10285
gene id: 1224162:B840_RS10285
uniprot id: A0A0B6TTS1
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1224162:B840 RS01855
gene id: 1224162:B840_RS01855
uniprot id: A0A0B6TTC7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1224162:B840 RS06245
gene id: 1224162:B840_RS06245
uniprot id: A0A0B6TLS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane

1224162:B840 RS06045
gene id: 1224162:B840_RS06045
uniprot id: A0A0B6TVU7
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

1224162:B840 RS11960
gene id: 1224162:B840_RS11960
uniprot id: A0A0B6TQ18
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

1224162:B840 RS01935
gene id: 1224162:B840_RS01935
uniprot id: A0A0B6TDM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1224162:B840 RS00370
gene id: 1224162:B840_RS00370
uniprot id: A0A0B6TIB2
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS11390
gene id: 1224162:B840_RS11390
uniprot id: A0A0B6TIW0
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS08605
gene id: 1224162:B840_RS08605
uniprot id: A0A0B6TSZ9
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

1224162:B840 RS05190
gene id: 1224162:B840_RS05190
uniprot id: A0A0B6TSU1
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS01945
gene id: 1224162:B840_RS01945
uniprot id: A0A0B6TP41
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1224162:B840 RS06115
gene id: 1224162:B840_RS06115
uniprot id: A0A0B6TFW1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1224162:B840 RS02430
gene id: 1224162:B840_RS02430
uniprot id: A0A0B6TPD3
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS03270
gene id: 1224162:B840_RS03270
uniprot id: A0A0B6TEA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1224162:B840 RS06520
gene id: 1224162:B840_RS06520
uniprot id: A0A0B6TG26
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

1224162:B840 RS10580
gene id: 1224162:B840_RS10580
uniprot id: A0A0B6TTY3
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS02695
gene id: 1224162:B840_RS02695
uniprot id: A0A0B6TE11
names: Similarity
messages: Belongs to the thymidylate kinase family.

1224162:B840 RS03605
gene id: 1224162:B840_RS03605
uniprot id: A0A0B6TUG5
names: Cofactor
messages: Can also use Mn(2+) ion.

1224162:B840 RS01020
gene id: 1224162:B840_RS01020
uniprot id: A0A0B6TIW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Homodimer.

1224162:B840 RS11220
gene id: 1224162:B840_RS11220
uniprot id: A0A0B6TPQ8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1224162:B840 RS02400
gene id: 1224162:B840_RS02400
uniprot id: A0A0B6TJJ7
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1224162:B840 RS01345
gene id: 1224162:B840_RS01345
uniprot id: A0A0B6TT39
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1224162:B840 RS10480
gene id: 1224162:B840_RS10480
uniprot id: A0A0B6TTW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1224162:B840 RS03045
gene id: 1224162:B840_RS03045
uniprot id: A0A0B6TRP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1224162:B840 RS02165
gene id: 1224162:B840_RS02165
uniprot id: A0A0B6TJF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

1224162:B840 RS02050
gene id: 1224162:B840_RS02050
uniprot id: A0A0B6TR35
names: Similarity
messages: Belongs to the WXG100 family.

1224162:B840 RS08270
gene id: 1224162:B840_RS08270
uniprot id: A0A0B6TSN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1224162:B840 RS07750
gene id: 1224162:B840_RS07750
uniprot id: A0A0B6TSB2
names: Similarity
messages: Belongs to the UPF0102 family.

1224162:B840 RS05030
gene id: 1224162:B840_RS05030
uniprot id: A0A0B6TKY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1224162:B840 RS03040
gene id: 1224162:B840_RS03040
uniprot id: A0A0B6TPR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1224162:B840 RS02335
gene id: 1224162:B840_RS02335
uniprot id: A0A0B6TTL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS10315
gene id: 1224162:B840_RS10315
uniprot id: A0A0B6TY61
names: Similarity
messages: Belongs to the CsoR family.

1224162:B840 RS03470
gene id: 1224162:B840_RS03470
uniprot id: A0A0B6TQ20
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS07735
gene id: 1224162:B840_RS07735
uniprot id: A0A0B6TWN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1224162:B840 RS01745
gene id: 1224162:B840_RS01745
uniprot id: A0A0B6TP09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1224162:B840 RS05935
gene id: 1224162:B840_RS05935
uniprot id: A0A0B6TTB1
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS09920
gene id: 1224162:B840_RS09920
uniprot id: A0A0B6TNU0
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

1224162:B840 RS10885
gene id: 1224162:B840_RS10885
uniprot id: A0A0B6TYK2
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS07480
gene id: 1224162:B840_RS07480
uniprot id: A0A0B6TS55
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1224162:B840 RS07180
gene id: 1224162:B840_RS07180
uniprot id: A0A0B6TS01
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1224162:B840 RS08025
gene id: 1224162:B840_RS08025
uniprot id: A0A0B6TSI0
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1224162:B840 RS01150
gene id: 1224162:B840_RS01150
uniprot id: A0A0B6TD84
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

1224162:B840 RS08450
gene id: 1224162:B840_RS08450
uniprot id: A0A0B6TX68
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1224162:B840 RS09840
gene id: 1224162:B840_RS09840
uniprot id: A0A0B6THZ2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1224162:B840 RS06760
gene id: 1224162:B840_RS06760
uniprot id: A0A0B6TTQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1224162:B840 RS09150
gene id: 1224162:B840_RS09150
uniprot id: A0A0B6TXM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224162:B840 RS03015
gene id: 1224162:B840_RS03015
uniprot id: A0A0B6TPQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

1224162:B840 RS11740
gene id: 1224162:B840_RS11740
uniprot id: A0A0B6TUL2
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS02310
gene id: 1224162:B840_RS02310
uniprot id: A0A0B6TTK6
names: Subcellular Location Annotation
messages: Cytoplasm

1224162:B840 RS02435
gene id: 1224162:B840_RS02435
uniprot id: A0A0B6TRA5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS03165
gene id: 1224162:B840_RS03165
uniprot id: A0A0B6TE85
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1224162:B840 RS07740
gene id: 1224162:B840_RS07740
uniprot id: A0A0B6TGQ7
names: Similarity
messages: Belongs to the DprA/Smf family.

1224162:B840 RS07780
gene id: 1224162:B840_RS07780
uniprot id: A0A0B6TU89
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS12160
gene id: 1224162:B840_RS12160
uniprot id: A0A0B6TUS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1224162:B840 RS10090
gene id: 1224162:B840_RS10090
uniprot id: A0A0B6TVJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1224162:B840 RS09280
gene id: 1224162:B840_RS09280
uniprot id: A0A0B6TXP1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1224162:B840 RS00715
gene id: 1224162:B840_RS00715
uniprot id: A0A0B6TSN8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1224162:B840 RS07720
gene id: 1224162:B840_RS07720
uniprot id: A0A0B6TMI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1224162:B840 RS08525
gene id: 1224162:B840_RS08525
uniprot id: A0A0B6THA1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

1224162:B840 RS03855
gene id: 1224162:B840_RS03855
uniprot id: A0A0B6TS70
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

1224162:B840 RS12145
gene id: 1224162:B840_RS12145
uniprot id: A0A0B6TZA4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS10800
gene id: 1224162:B840_RS10800
uniprot id: A0A0B6TPD1
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

1224162:B840 RS06715
gene id: 1224162:B840_RS06715
uniprot id: A0A0B6TW49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1224162:B840 RS04540
gene id: 1224162:B840_RS04540
uniprot id: A0A0B6TSH3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1224162:B840 RS06545
gene id: 1224162:B840_RS06545
uniprot id: A0A0B6TG30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm

1224162:B840 RS06065
gene id: 1224162:B840_RS06065
uniprot id: A0A0B6TTF5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS11280
gene id: 1224162:B840_RS11280
uniprot id: A0A0B6TWE0
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS04385
gene id: 1224162:B840_RS04385
uniprot id: A0A0B6TEU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS08535
gene id: 1224162:B840_RS08535
uniprot id: A0A0B6TSV9
names: Similarity
messages: Belongs to the glutamine synthetase family.

1224162:B840 RS03390
gene id: 1224162:B840_RS03390
uniprot id: A0A0B6TRX3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1224162:B840 RS10395
gene id: 1224162:B840_RS10395
uniprot id: A0A0B6TI88
names: Similarity
messages: Belongs to the PstS family.

1224162:B840 RS01845
gene id: 1224162:B840_RS01845
uniprot id: A0A0B6TP25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1224162:B840 RS12360
gene id: 1224162:B840_RS12360
uniprot id: A0A0B6TWY6
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

1224162:B840 RS05890
gene id: 1224162:B840_RS05890
uniprot id: A0A0B6TVQ0
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1224162:B840 RS08220
gene id: 1224162:B840_RS08220
uniprot id: A0A0B6TSM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

1224162:B840 RS03600
gene id: 1224162:B840_RS03600
uniprot id: A0A0B6TS36
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the malate synthase family. GlcB subfamily.
messages: Cytoplasm
messages: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1224162:B840 RS00180
gene id: 1224162:B840_RS00180
uniprot id: A0A0B6TCK8
names: Similarity
messages: Belongs to the non-flavoprotein flavin reductase family.

1224162:B840 RS12730
gene id: 1224162:B840_RS12730
uniprot id: A0A0B6TV83
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS06880
gene id: 1224162:B840_RS06880
uniprot id: A0A0B6TRV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1224162:B840 RS03950
gene id: 1224162:B840_RS03950
uniprot id: A0A0B6TQ99
names: Similarity
messages: Belongs to the FBPase class 2 family.

1224162:B840 RS08455
gene id: 1224162:B840_RS08455
uniprot id: A0A0B6TH80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1224162:B840 RS10245
gene id: 1224162:B840_RS10245
uniprot id: A0A0B6TTR5
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS08880
gene id: 1224162:B840_RS08880
uniprot id: A0A0B6TV06
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1224162:B840 RS10160
gene id: 1224162:B840_RS10160
uniprot id: A0A0B6TTP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

1224162:B840 RS05025
gene id: 1224162:B840_RS05025
uniprot id: A0A0B6TF58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1224162:B840 RS10695
gene id: 1224162:B840_RS10695
uniprot id: A0A0B6TVX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DisA family.
messages: Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
messages: Homooctamer.
messages: Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.

1224162:B840 RS01275
gene id: 1224162:B840_RS01275
uniprot id: A0A0B6TT27
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1224162:B840 RS09270
gene id: 1224162:B840_RS09270
uniprot id: A0A0B6TTA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1224162:B840 RS00935
gene id: 1224162:B840_RS00935
uniprot id: A0A0B6TD11
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS09380
gene id: 1224162:B840_RS09380
uniprot id: A0A0B6TXQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1224162:B840 RS03835
gene id: 1224162:B840_RS03835
uniprot id: A0A0B6TUK2
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1224162:B840 RS03825
gene id: 1224162:B840_RS03825
uniprot id: A0A0B6TQ82
names: Similarity
messages: Belongs to the AHA1 family.

1224162:B840 RS02565
gene id: 1224162:B840_RS02565
uniprot id: A0A0B6TTQ6
names: Similarity
messages: Belongs to the AccD/PCCB family.

1224162:B840 RS05135
gene id: 1224162:B840_RS05135
uniprot id: A0A0B6TQV3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS10440
gene id: 1224162:B840_RS10440
uniprot id: A0A0B6TY95
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

1224162:B840 RS08225
gene id: 1224162:B840_RS08225
uniprot id: A0A0B6TUJ7
names: Similarity
messages: Belongs to the YggT family.

1224162:B840 RS11540
gene id: 1224162:B840_RS11540
uniprot id: A0A0B6TPV5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS11465
gene id: 1224162:B840_RS11465
uniprot id: A0A0B6TPU3
names: Similarity
messages: Belongs to the AccD/PCCB family.

1224162:B840 RS06855
gene id: 1224162:B840_RS06855
uniprot id: A0A0B6TRU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS01920
gene id: 1224162:B840_RS01920
uniprot id: A0A0B6TP38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1224162:B840 RS07435
gene id: 1224162:B840_RS07435
uniprot id: A0A0B6TU16
names: Similarity
messages: Belongs to the PspA/IM30 family.

1224162:B840 RS03075
gene id: 1224162:B840_RS03075
uniprot id: A0A0B6TJX2
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS05480
gene id: 1224162:B840_RS05480
uniprot id: A0A0B6TSZ8
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.

1224162:B840 RS00920
gene id: 1224162:B840_RS00920
uniprot id: A0A0B6TQG1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

1224162:B840 RS08585
gene id: 1224162:B840_RS08585
uniprot id: A0A0B6TUW2
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS01010
gene id: 1224162:B840_RS01010
uniprot id: A0A0B6TSX5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

1224162:B840 RS04340
gene id: 1224162:B840_RS04340
uniprot id: A0A0B6TKL3
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1224162:B840 RS07485
gene id: 1224162:B840_RS07485
uniprot id: A0A0B6TU24
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS08145
gene id: 1224162:B840_RS08145
uniprot id: A0A0B6TSK9
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1224162:B840 RS05815
gene id: 1224162:B840_RS05815
uniprot id: A0A0B6TVN4
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1224162:B840 RS04635
gene id: 1224162:B840_RS04635
uniprot id: A0A0B6TQK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

1224162:B840 RS08460
gene id: 1224162:B840_RS08460
uniprot id: A0A0B6TN23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1224162:B840 RS09450
gene id: 1224162:B840_RS09450
uniprot id: A0A0B6TV82
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1224162:B840 RS00480
gene id: 1224162:B840_RS00480
uniprot id: A0A0B6TN88
names: Similarity
messages: Belongs to the heme oxygenase family.

1224162:B840 RS01480
gene id: 1224162:B840_RS01480
uniprot id: A0A0B6TNW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1224162:B840 RS02535
gene id: 1224162:B840_RS02535
uniprot id: A0A0B6TRC6
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Could possibly oxidize fatty acids using specific components.

1224162:B840 RS02330
gene id: 1224162:B840_RS02330
uniprot id: A0A0B6TR85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
messages: Cytoplasm
messages: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.

1224162:B840 RS07575
gene id: 1224162:B840_RS07575
uniprot id: A0A0B6TS77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1224162:B840 RS07105
gene id: 1224162:B840_RS07105
uniprot id: A0A0B6TRY9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1224162:B840 RS08390
gene id: 1224162:B840_RS08390
uniprot id: A0A0B6TSS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Cell membrane
messages: Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.

1224162:B840 RS11965
gene id: 1224162:B840_RS11965
uniprot id: A0A0B6TUP6
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS07940
gene id: 1224162:B840_RS07940
uniprot id: A0A0B6TGU7
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

1224162:B840 RS04430
gene id: 1224162:B840_RS04430
uniprot id: A0A0B6TEV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1224162:B840 RS07190
gene id: 1224162:B840_RS07190
uniprot id: A0A0B6TWC2
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1224162:B840 RS06680
gene id: 1224162:B840_RS06680
uniprot id: A0A0B6TRR8
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1224162:B840 RS06615
gene id: 1224162:B840_RS06615
uniprot id: A0A0B6TW32
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1224162:B840 RS03640
gene id: 1224162:B840_RS03640
uniprot id: A0A0B6TKA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm

1224162:B840 RS11190
gene id: 1224162:B840_RS11190
uniprot id: A0A0B6TIT4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1224162:B840 RS01980
gene id: 1224162:B840_RS01980
uniprot id: A0A0B6TTE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1224162:B840 RS08160
gene id: 1224162:B840_RS08160
uniprot id: A0A0B6TH05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

1224162:B840 RS03440
gene id: 1224162:B840_RS03440
uniprot id: A0A0B6TQ14
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1224162:B840 RS02680
gene id: 1224162:B840_RS02680
uniprot id: A0A0B6TPI3
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

1224162:B840 RS01850
gene id: 1224162:B840_RS01850
uniprot id: A0A0B6TQY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1224162:B840 RS03495
gene id: 1224162:B840_RS03495
uniprot id: A0A0B6TQ27
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Monomer.

1224162:B840 RS06770
gene id: 1224162:B840_RS06770
uniprot id: A0A0B6TG73
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

1224162:B840 RS06675
gene id: 1224162:B840_RS06675
uniprot id: A0A0B6TLZ5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

1224162:B840 RS01955
gene id: 1224162:B840_RS01955
uniprot id: A0A0B6TTE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1224162:B840 RS11155
gene id: 1224162:B840_RS11155
uniprot id: A0A0B6TWB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224162:B840 RS06500
gene id: 1224162:B840_RS06500
uniprot id: A0A0B6TLW6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

1224162:B840 RS06915
gene id: 1224162:B840_RS06915
uniprot id: A0A0B6TW84
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

1224162:B840 RS01735
gene id: 1224162:B840_RS01735
uniprot id: A0A0B6TDI1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1224162:B840 RS04600
gene id: 1224162:B840_RS04600
uniprot id: A0A0B6TEY0
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

1224162:B840 RS10345
gene id: 1224162:B840_RS10345
uniprot id: A0A0B6TY68
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS08410
gene id: 1224162:B840_RS08410
uniprot id: A0A0B6TN12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

1224162:B840 RS04380
gene id: 1224162:B840_RS04380
uniprot id: A0A0B6TUT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS01985
gene id: 1224162:B840_RS01985
uniprot id: A0A0B6TDN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1224162:B840 RS12245
gene id: 1224162:B840_RS12245
uniprot id: A0A0B6TZC3
names: Similarity
messages: Belongs to the thioredoxin family.

1224162:B840 RS08960
gene id: 1224162:B840_RS08960
uniprot id: A0A0B6THK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

1224162:B840 RS04310
gene id: 1224162:B840_RS04310
uniprot id: A0A0B6TET4
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS10915
gene id: 1224162:B840_RS10915
uniprot id: A0A0B6TIK7
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

1224162:B840 RS07525
gene id: 1224162:B840_RS07525
uniprot id: A0A0B6TS65
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1224162:B840 RS06670
gene id: 1224162:B840_RS06670
uniprot id: A0A0B6TG54
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1224162:B840 RS11175
gene id: 1224162:B840_RS11175
uniprot id: A0A0B6TUD6
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

1224162:B840 RS09620
gene id: 1224162:B840_RS09620
uniprot id: A0A0B6TTF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1224162:B840 RS08670
gene id: 1224162:B840_RS08670
uniprot id: A0A0B6THF1
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

1224162:B840 RS04250
gene id: 1224162:B840_RS04250
uniprot id: A0A0B6TQE7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1224162:B840 RS08805
gene id: 1224162:B840_RS08805
uniprot id: A0A0B6THH4
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1224162:B840 RS09390
gene id: 1224162:B840_RS09390
uniprot id: A0A0B6TNK7
names: Similarity
messages: Belongs to the pirin family.

1224162:B840 RS04630
gene id: 1224162:B840_RS04630
uniprot id: A0A0B6TKR2
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1224162:B840 RS06725
gene id: 1224162:B840_RS06725
uniprot id: A0A0B6TM04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1224162:B840 RS07455
gene id: 1224162:B840_RS07455
uniprot id: A0A0B6TS50
names: Similarity
messages: Belongs to the YciI family.

1224162:B840 RS08885
gene id: 1224162:B840_RS08885
uniprot id: A0A0B6TXI6
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1224162:B840 RS00410
gene id: 1224162:B840_RS00410
uniprot id: A0A0B6TSH1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

1224162:B840 RS07290
gene id: 1224162:B840_RS07290
uniprot id: A0A0B6TWE2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1224162:B840 RS09950
gene id: 1224162:B840_RS09950
uniprot id: A0A0B6TNU7
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

1224162:B840 RS10135
gene id: 1224162:B840_RS10135
uniprot id: A0A0B6TTP4
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1224162:B840 RS07365
gene id: 1224162:B840_RS07365
uniprot id: A0A0B6TWF9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

1224162:B840 RS06450
gene id: 1224162:B840_RS06450
uniprot id: A0A0B6TLV7
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1224162:B840 RS01715
gene id: 1224162:B840_RS01715
uniprot id: A0A0B6TJ74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1224162:B840 RS07610
gene id: 1224162:B840_RS07610
uniprot id: A0A0B6TWL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Membrane

1224162:B840 RS10945
gene id: 1224162:B840_RS10945
uniprot id: A0A0B6TPG9
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1224162:B840 RS09180
gene id: 1224162:B840_RS09180
uniprot id: A0A0B6THN7
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1224162:B840 RS01880
gene id: 1224162:B840_RS01880
uniprot id: A0A0B6TTD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1224162:B840 RS06900
gene id: 1224162:B840_RS06900
uniprot id: A0A0B6TM34
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1224162:B840 RS02120
gene id: 1224162:B840_RS02120
uniprot id: A0A0B6TP72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.

1224162:B840 RS11950
gene id: 1224162:B840_RS11950
uniprot id: A0A0B6TZ68
names: Similarity
messages: Belongs to the UPF0371 family.

1224162:B840 RS05530
gene id: 1224162:B840_RS05530
uniprot id: A0A0B6TT11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS05100
gene id: 1224162:B840_RS05100
uniprot id: A0A0B6TF75
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1224162:B840 RS10085
gene id: 1224162:B840_RS10085
uniprot id: A0A0B6TTN4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1224162:B840 RS07855
gene id: 1224162:B840_RS07855
uniprot id: A0A0B6TUA6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1224162:B840 RS01765
gene id: 1224162:B840_RS01765
uniprot id: A0A0B6TJ81
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1224162:B840 RS09825
gene id: 1224162:B840_RS09825
uniprot id: A0A0B6TVE6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1224162:B840 RS06140
gene id: 1224162:B840_RS06140
uniprot id: A0A0B6TFW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

1224162:B840 RS01430
gene id: 1224162:B840_RS01430
uniprot id: A0A0B6TJ29
names: Similarity
messages: Belongs to the CsoR family.

1224162:B840 RS08260
gene id: 1224162:B840_RS08260
uniprot id: A0A0B6TH27
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS09335
gene id: 1224162:B840_RS09335
uniprot id: A0A0B6THR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1224162:B840 RS02765
gene id: 1224162:B840_RS02765
uniprot id: A0A0B6TTV5
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

1224162:B840 RS07920
gene id: 1224162:B840_RS07920
uniprot id: A0A0B6TMN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1224162:B840 RS00300
gene id: 1224162:B840_RS00300
uniprot id: A0A0B6TN53
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS09585
gene id: 1224162:B840_RS09585
uniprot id: A0A0B6TNN7
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

1224162:B840 RS01190
gene id: 1224162:B840_RS01190
uniprot id: A0A0B6TQN5
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS08900
gene id: 1224162:B840_RS08900
uniprot id: A0A0B6TV09
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1224162:B840 RS05115
gene id: 1224162:B840_RS05115
uniprot id: A0A0B6TSS6
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

1224162:B840 RS07260
gene id: 1224162:B840_RS07260
uniprot id: A0A0B6TTY9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1224162:B840 RS06610
gene id: 1224162:B840_RS06610
uniprot id: A0A0B6TTN7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

1224162:B840 RS09640
gene id: 1224162:B840_RS09640
uniprot id: A0A0B6THV7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1224162:B840 RS11490
gene id: 1224162:B840_RS11490
uniprot id: A0A0B6TPU7
names: Similarity
messages: Belongs to the mycobacterial A85 antigen family.

1224162:B840 RS07580
gene id: 1224162:B840_RS07580
uniprot id: A0A0B6TU42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1224162:B840 RS07665
gene id: 1224162:B840_RS07665
uniprot id: A0A0B6TGP1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

1224162:B840 RS06535
gene id: 1224162:B840_RS06535
uniprot id: A0A0B6TTM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1224162:B840 RS01085
gene id: 1224162:B840_RS01085
uniprot id: A0A0B6TIX6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1224162:B840 RS10795
gene id: 1224162:B840_RS10795
uniprot id: A0A0B6TIH6
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

1224162:B840 RS07460
gene id: 1224162:B840_RS07460
uniprot id: A0A0B6TU22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

1224162:B840 RS05625
gene id: 1224162:B840_RS05625
uniprot id: A0A0B6TR51
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1224162:B840 RS12275
gene id: 1224162:B840_RS12275
uniprot id: A0A0B6TJC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1224162:B840 RS00120
gene id: 1224162:B840_RS00120
uniprot id: A0A0B6TCJ8
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS00115
gene id: 1224162:B840_RS00115
uniprot id: A0A0B6TSA7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1224162:B840 RS08985
gene id: 1224162:B840_RS08985
uniprot id: A0A0B6THK4
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1224162:B840 RS08490
gene id: 1224162:B840_RS08490
uniprot id: A0A0B6TSU9
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS02245
gene id: 1224162:B840_RS02245
uniprot id: A0A0B6TJG9
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS08105
gene id: 1224162:B840_RS08105
uniprot id: A0A0B6TWX6
names: Similarity
messages: Belongs to the IMPACT family.

1224162:B840 RS01550
gene id: 1224162:B840_RS01550
uniprot id: A0A0B6TNY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

1224162:B840 RS10385
gene id: 1224162:B840_RS10385
uniprot id: A0A0B6TVQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1224162:B840 RS03185
gene id: 1224162:B840_RS03185
uniprot id: A0A0B6TU50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1224162:B840 RS10225
gene id: 1224162:B840_RS10225
uniprot id: A0A0B6TVM6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1224162:B840 RS09125
gene id: 1224162:B840_RS09125
uniprot id: A0A0B6TXL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCCT transporter (TC 2.A.15) family.
messages: Membrane

1224162:B840 RS08240
gene id: 1224162:B840_RS08240
uniprot id: A0A0B6TMX1
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

1224162:B840 RS07220
gene id: 1224162:B840_RS07220
uniprot id: A0A0B6TGE6
names: Similarity
messages: Belongs to the serine/threonine dehydratase family. DsdA subfamily.

1224162:B840 RS12015
gene id: 1224162:B840_RS12015
uniprot id: A0A0B6TUQ4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1224162:B840 RS03105
gene id: 1224162:B840_RS03105
uniprot id: A0A0B6TRQ5
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

1224162:B840 RS10745
gene id: 1224162:B840_RS10745
uniprot id: A0A0B6TIG4
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS09010
gene id: 1224162:B840_RS09010
uniprot id: A0A0B6THK8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1224162:B840 RS10565
gene id: 1224162:B840_RS10565
uniprot id: A0A0B6TYC5
names: Similarity
messages: Belongs to the TPP enzyme family.

1224162:B840 RS04745
gene id: 1224162:B840_RS04745
uniprot id: A0A0B6TV01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Membrane

1224162:B840 RS03845
gene id: 1224162:B840_RS03845
uniprot id: A0A0B6TKC6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.
messages: Belongs to the MshB deacetylase family. Mca subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Monomer.

1224162:B840 RS11970
gene id: 1224162:B840_RS11970
uniprot id: A0A0B6TWP1
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

1224162:B840 RS02305
gene id: 1224162:B840_RS02305
uniprot id: A0A0B6TR80
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS05265
gene id: 1224162:B840_RS05265
uniprot id: A0A0B6TSV6
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1224162:B840 RS00945
gene id: 1224162:B840_RS00945
uniprot id: A0A0B6TNK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1224162:B840 RS00055
gene id: 1224162:B840_RS00055
uniprot id: A0A0B6TS99
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1224162:B840 RS09635
gene id: 1224162:B840_RS09635
uniprot id: A0A0B6TXU6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1224162:B840 RS00980
gene id: 1224162:B840_RS00980
uniprot id: A0A0B6TQH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1224162:B840 RS09365
gene id: 1224162:B840_RS09365
uniprot id: A0A0B6TNK4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1224162:B840 RS06620
gene id: 1224162:B840_RS06620
uniprot id: A0A0B6TG43
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1224162:B840 RS07185
gene id: 1224162:B840_RS07185
uniprot id: A0A0B6TTX6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1224162:B840 RS06870
gene id: 1224162:B840_RS06870
uniprot id: A0A0B6TG90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1224162:B840 RS04315
gene id: 1224162:B840_RS04315
uniprot id: A0A0B6TKK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
messages: Cell membrane
messages: Mediates zinc uptake. May also transport other divalent cations.
messages: Membrane

1224162:B840 RS05455
gene id: 1224162:B840_RS05455
uniprot id: A0A0B6TSZ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1224162:B840 RS01080
gene id: 1224162:B840_RS01080
uniprot id: A0A0B6TD71
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS01625
gene id: 1224162:B840_RS01625
uniprot id: A0A0B6TNZ1
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS07960
gene id: 1224162:B840_RS07960
uniprot id: A0A0B6TWT4
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

1224162:B840 RS01675
gene id: 1224162:B840_RS01675
uniprot id: A0A0B6TP00
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1224162:B840 RS06190
gene id: 1224162:B840_RS06190
uniprot id: A0A0B6TFX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1224162:B840 RS07795
gene id: 1224162:B840_RS07795
uniprot id: A0A0B6TMK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

1224162:B840 RS02930
gene id: 1224162:B840_RS02930
uniprot id: A0A0B6TE48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

1224162:B840 RS11030
gene id: 1224162:B840_RS11030
uniprot id: A0A0B6TW72
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS08195
gene id: 1224162:B840_RS08195
uniprot id: A0A0B6TSM0
names: Similarity
messages: Belongs to the asparaginase 1 family.

1224162:B840 RS05710
gene id: 1224162:B840_RS05710
uniprot id: A0A0B6TFK3
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1224162:B840 RS11120
gene id: 1224162:B840_RS11120
uniprot id: A0A0B6TPL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1224162:B840 RS08405
gene id: 1224162:B840_RS08405
uniprot id: A0A0B6TH66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

1224162:B840 RS04395
gene id: 1224162:B840_RS04395
uniprot id: A0A0B6TQH1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1224162:B840 RS09100
gene id: 1224162:B840_RS09100
uniprot id: A0A0B6TXL7
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS04920
gene id: 1224162:B840_RS04920
uniprot id: A0A0B6TV36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

1224162:B840 RS01995
gene id: 1224162:B840_RS01995
uniprot id: A0A0B6TP49
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1224162:B840 RS10400
gene id: 1224162:B840_RS10400
uniprot id: A0A0B6TP37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. MshD subfamily.
messages: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
messages: Monomer.

1224162:B840 RS05040
gene id: 1224162:B840_RS05040
uniprot id: A0A0B6TSR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1224162:B840 RS04825
gene id: 1224162:B840_RS04825
uniprot id: A0A0B6TQP8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1224162:B840 RS11715
gene id: 1224162:B840_RS11715
uniprot id: A0A0B6TPY0
names: Similarity
messages: Belongs to the universal stress protein A family.

1224162:B840 RS10690
gene id: 1224162:B840_RS10690
uniprot id: A0A0B6TU05
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1224162:B840 RS09005
gene id: 1224162:B840_RS09005
uniprot id: A0A0B6TXK3
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS08325
gene id: 1224162:B840_RS08325
uniprot id: A0A0B6TUM8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1224162:B840 RS02895
gene id: 1224162:B840_RS02895
uniprot id: A0A0B6TTY6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS03325
gene id: 1224162:B840_RS03325
uniprot id: A0A0B6TK32
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1224162:B840 RS10570
gene id: 1224162:B840_RS10570
uniprot id: A0A0B6TIC5
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS01805
gene id: 1224162:B840_RS01805
uniprot id: A0A0B6TTB8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1224162:B840 RS06530
gene id: 1224162:B840_RS06530
uniprot id: A0A0B6TRN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

1224162:B840 RS06355
gene id: 1224162:B840_RS06355
uniprot id: A0A0B6TRL1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS05270
gene id: 1224162:B840_RS05270
uniprot id: A0A0B6TVA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1224162:B840 RS03140
gene id: 1224162:B840_RS03140
uniprot id: A0A0B6TE80
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1224162:B840 RS08660
gene id: 1224162:B840_RS08660
uniprot id: A0A0B6TUY0
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1224162:B840 RS12375
gene id: 1224162:B840_RS12375
uniprot id: A0A0B6TQA9
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1224162:B840 RS11375
gene id: 1224162:B840_RS11375
uniprot id: A0A0B6TUG0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

1224162:B840 RS09730
gene id: 1224162:B840_RS09730
uniprot id: A0A0B6THX1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1224162:B840 RS06630
gene id: 1224162:B840_RS06630
uniprot id: A0A0B6TRQ9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS06495
gene id: 1224162:B840_RS06495
uniprot id: A0A0B6TG20
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

1224162:B840 RS07865
gene id: 1224162:B840_RS07865
uniprot id: A0A0B6TGT2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1224162:B840 RS12490
gene id: 1224162:B840_RS12490
uniprot id: A0A0B6TV24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1224162:B840 RS10620
gene id: 1224162:B840_RS10620
uniprot id: A0A0B6TYD6
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

1224162:B840 RS05720
gene id: 1224162:B840_RS05720
uniprot id: A0A0B6TR71
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1224162:B840 RS04785
gene id: 1224162:B840_RS04785
uniprot id: A0A0B6TQN6
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS11865
gene id: 1224162:B840_RS11865
uniprot id: A0A0B6TQ02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

1224162:B840 RS10470
gene id: 1224162:B840_RS10470
uniprot id: A0A0B6TIA4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1224162:B840 RS08975
gene id: 1224162:B840_RS08975
uniprot id: A0A0B6TV18
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS07895
gene id: 1224162:B840_RS07895
uniprot id: A0A0B6TMM8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1224162:B840 RS06410
gene id: 1224162:B840_RS06410
uniprot id: A0A0B6TTK9
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

1224162:B840 RS11735
gene id: 1224162:B840_RS11735
uniprot id: A0A0B6TPY4
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS11730
gene id: 1224162:B840_RS11730
uniprot id: A0A0B6TJ28
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS05840
gene id: 1224162:B840_RS05840
uniprot id: A0A0B6TVP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1224162:B840 RS01925
gene id: 1224162:B840_RS01925
uniprot id: A0A0B6TR01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1224162:B840 RS10435
gene id: 1224162:B840_RS10435
uniprot id: A0A0B6TVR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1224162:B840 RS12020
gene id: 1224162:B840_RS12020
uniprot id: A0A0B6TWP7
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Could possibly oxidize fatty acids using specific components.

1224162:B840 RS08930
gene id: 1224162:B840_RS08930
uniprot id: A0A0B6TXJ3
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

1224162:B840 RS00320
gene id: 1224162:B840_RS00320
uniprot id: A0A0B6TI99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224162:B840 RS01605
gene id: 1224162:B840_RS01605
uniprot id: A0A0B6TQU5
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS09040
gene id: 1224162:B840_RS09040
uniprot id: A0A0B6TNF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1224162:B840 RS04555
gene id: 1224162:B840_RS04555
uniprot id: A0A0B6TKQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1224162:B840 RS06745
gene id: 1224162:B840_RS06745
uniprot id: A0A0B6TG68
names: Similarity
messages: Belongs to the peptidase A24 family.

1224162:B840 RS10370
gene id: 1224162:B840_RS10370
uniprot id: A0A0B6TI84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1224162:B840 RS05495
gene id: 1224162:B840_RS05495
uniprot id: A0A0B6TL95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1224162:B840 RS02775
gene id: 1224162:B840_RS02775
uniprot id: A0A0B6TJR3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1224162:B840 RS05630
gene id: 1224162:B840_RS05630
uniprot id: A0A0B6TT36
names: Similarity
messages: Belongs to the universal stress protein A family.

1224162:B840 RS07385
gene id: 1224162:B840_RS07385
uniprot id: A0A0B6TU09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS10115
gene id: 1224162:B840_RS10115
uniprot id: A0A0B6TVK5
names: Similarity
messages: Belongs to the peptidase S58 family.

1224162:B840 RS11885
gene id: 1224162:B840_RS11885
uniprot id: A0A0B6TQ06
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1224162:B840 RS11650
gene id: 1224162:B840_RS11650
uniprot id: A0A0B6TWJ3
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS01895
gene id: 1224162:B840_RS01895
uniprot id: A0A0B6TP34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1224162:B840 RS04320
gene id: 1224162:B840_RS04320
uniprot id: A0A0B6TQF9
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS00335
gene id: 1224162:B840_RS00335
uniprot id: A0A0B6TSF4
names: Cofactor
messages: Binds 1 FAD per subunit.

1224162:B840 RS12045
gene id: 1224162:B840_RS12045
uniprot id: A0A0B6TWQ1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1224162:B840 RS10955
gene id: 1224162:B840_RS10955
uniprot id: A0A0B6TW50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Membrane

1224162:B840 RS10805
gene id: 1224162:B840_RS10805
uniprot id: A0A0B6TU32
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1224162:B840 RS02725
gene id: 1224162:B840_RS02725
uniprot id: A0A0B6TJQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1224162:B840 RS05900
gene id: 1224162:B840_RS05900
uniprot id: A0A0B6TLK0
names: Subcellular Location Annotation
messages: Secreted

1224162:B840 RS06780
gene id: 1224162:B840_RS06780
uniprot id: A0A0B6TRT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

1224162:B840 RS03710
gene id: 1224162:B840_RS03710
uniprot id: A0A0B6TKB1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1224162:B840 RS03985
gene id: 1224162:B840_RS03985
uniprot id: A0A0B6TUM5
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

1224162:B840 RS05355
gene id: 1224162:B840_RS05355
uniprot id: A0A0B6TL63
names: Similarity
messages: Belongs to the isochorismate synthase family.

1224162:B840 RS12615
gene id: 1224162:B840_RS12615
uniprot id: A0A0B6TV52
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS11425
gene id: 1224162:B840_RS11425
uniprot id: A0A0B6TWG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

1224162:B840 RS07990
gene id: 1224162:B840_RS07990
uniprot id: A0A0B6TGW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1224162:B840 RS11710
gene id: 1224162:B840_RS11710
uniprot id: A0A0B6TJ23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1224162:B840 RS12090
gene id: 1224162:B840_RS12090
uniprot id: A0A0B6TWR0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS03530
gene id: 1224162:B840_RS03530
uniprot id: A0A0B6TUE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1224162:B840 RS07965
gene id: 1224162:B840_RS07965
uniprot id: A0A0B6TGV5
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

1224162:B840 RS02060
gene id: 1224162:B840_RS02060
uniprot id: A0A0B6TDP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1224162:B840 RS11910
gene id: 1224162:B840_RS11910
uniprot id: A0A0B6TQ10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

1224162:B840 RS11085
gene id: 1224162:B840_RS11085
uniprot id: A0A0B6TYQ8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS02500
gene id: 1224162:B840_RS02500
uniprot id: A0A0B6TJL4
names: Function
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.

1224162:B840 RS00650
gene id: 1224162:B840_RS00650
uniprot id: A0A0B6TII7
names: Similarity
messages: Belongs to the pirin family.

1224162:B840 RS03555
gene id: 1224162:B840_RS03555
uniprot id: A0A0B6TUF9
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1224162:B840 RS10880
gene id: 1224162:B840_RS10880
uniprot id: A0A0B6TW30
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1224162:B840 RS05750
gene id: 1224162:B840_RS05750
uniprot id: A0A0B6TT68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1224162:B840 RS06660
gene id: 1224162:B840_RS06660
uniprot id: A0A0B6TTP2
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

1224162:B840 RS09820
gene id: 1224162:B840_RS09820
uniprot id: A0A0B6TTI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS04915
gene id: 1224162:B840_RS04915
uniprot id: A0A0B6TSN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS05325
gene id: 1224162:B840_RS05325
uniprot id: A0A0B6TFC3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

1224162:B840 RS04985
gene id: 1224162:B840_RS04985
uniprot id: A0A0B6TQS4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1224162:B840 RS00775
gene id: 1224162:B840_RS00775
uniprot id: A0A0B6TIL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 85 family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS11555
gene id: 1224162:B840_RS11555
uniprot id: A0A0B6TZ10
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

1224162:B840 RS10230
gene id: 1224162:B840_RS10230
uniprot id: A0A0B6TY51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS01785
gene id: 1224162:B840_RS01785
uniprot id: A0A0B6TDJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1224162:B840 RS06865
gene id: 1224162:B840_RS06865
uniprot id: A0A0B6TW74
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1224162:B840 RS03290
gene id: 1224162:B840_RS03290
uniprot id: A0A0B6TU78
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1224162:B840 RS10180
gene id: 1224162:B840_RS10180
uniprot id: A0A0B6TNZ9
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

1224162:B840 RS02710
gene id: 1224162:B840_RS02710
uniprot id: A0A0B6TRG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpqB lipoprotein family.
messages: Cell membrane

1224162:B840 RS04005
gene id: 1224162:B840_RS04005
uniprot id: A0A0B6TS89
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1224162:B840 RS00640
gene id: 1224162:B840_RS00640
uniprot id: A0A0B6TSM1
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-69 and Arg-72) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

1224162:B840 RS01860
gene id: 1224162:B840_RS01860
uniprot id: A0A0B6TDK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1224162:B840 RS07970
gene id: 1224162:B840_RS07970
uniprot id: A0A0B6TMP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1224162:B840 RS07875
gene id: 1224162:B840_RS07875
uniprot id: A0A0B6TSE4
names: Similarity
messages: Belongs to the P(II) protein family.

1224162:B840 RS10770
gene id: 1224162:B840_RS10770
uniprot id: A0A0B6TIH0
names: Similarity
messages: Belongs to the pantothenate synthetase family.

1224162:B840 RS09165
gene id: 1224162:B840_RS09165
uniprot id: A0A0B6TT85
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1224162:B840 RS07285
gene id: 1224162:B840_RS07285
uniprot id: A0A0B6TTZ4
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1224162:B840 RS06070
gene id: 1224162:B840_RS06070
uniprot id: A0A0B6TVV8
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

1224162:B840 RS09445
gene id: 1224162:B840_RS09445
uniprot id: A0A0B6TTC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS03775
gene id: 1224162:B840_RS03775
uniprot id: A0A0B6TS59
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1224162:B840 RS01825
gene id: 1224162:B840_RS01825
uniprot id: A0A0B6TQY2
names: Similarity
messages: Belongs to the asp23 family.

1224162:B840 RS03090
gene id: 1224162:B840_RS03090
uniprot id: A0A0B6TU25
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

1224162:B840 RS06210
gene id: 1224162:B840_RS06210
uniprot id: A0A0B6TVX7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic ubiquitin-like protein family.
messages: Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.
messages: Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
messages: Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.
messages: The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.

1224162:B840 RS11010
gene id: 1224162:B840_RS11010
uniprot id: A0A0B6TYN7
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

1224162:B840 RS06220
gene id: 1224162:B840_RS06220
uniprot id: A0A0B6TLS5
names: Similarity
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Homohexamer. Assembles into a hexameric ring structure.

1224162:B840 RS06250
gene id: 1224162:B840_RS06250
uniprot id: A0A0B6TRJ8
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

1224162:B840 RS10375
gene id: 1224162:B840_RS10375
uniprot id: A0A0B6TP32
names: Similarity
messages: Belongs to the cytochrome P450 family.

1224162:B840 RS07245
gene id: 1224162:B840_RS07245
uniprot id: A0A0B6TGF0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1224162:B840 RS09525
gene id: 1224162:B840_RS09525
uniprot id: A0A0B6TXS8
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

1224162:B840 RS02315
gene id: 1224162:B840_RS02315
uniprot id: A0A0B6TDU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224162:B840 RS00010
gene id: 1224162:B840_RS00010
uniprot id: A0A0B6TCH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1224162:B840 RS10865
gene id: 1224162:B840_RS10865
uniprot id: A0A0B6TIJ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

1224162:B840 RS03305
gene id: 1224162:B840_RS03305
uniprot id: A0A0B6TPY1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1224162:B840 RS12125
gene id: 1224162:B840_RS12125
uniprot id: A0A0B6TJ95
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS08280
gene id: 1224162:B840_RS08280
uniprot id: A0A0B6TX21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1224162:B840 RS02610
gene id: 1224162:B840_RS02610
uniprot id: A0A0B6TRE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224162:B840 RS03435
gene id: 1224162:B840_RS03435
uniprot id: A0A0B6TK59
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1224162:B840 RS01240
gene id: 1224162:B840_RS01240
uniprot id: A0A0B6TQP3
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.

1224162:B840 RS06540
gene id: 1224162:B840_RS06540
uniprot id: A0A0B6TW22
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1224162:B840 RS09205
gene id: 1224162:B840_RS09205
uniprot id: A0A0B6TXM8
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS11925
gene id: 1224162:B840_RS11925
uniprot id: A0A0B6TZ63
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

1224162:B840 RS03280
gene id: 1224162:B840_RS03280
uniprot id: A0A0B6TPX4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1224162:B840 RS09020
gene id: 1224162:B840_RS09020
uniprot id: A0A0B6TT60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1224162:B840 RS03380
gene id: 1224162:B840_RS03380
uniprot id: A0A0B6TK44
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1224162:B840 RS03220
gene id: 1224162:B840_RS03220
uniprot id: A0A0B6TE94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1224162:B840 RS05760
gene id: 1224162:B840_RS05760
uniprot id: A0A0B6TFL4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS02325
gene id: 1224162:B840_RS02325
uniprot id: A0A0B6TPB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

1224162:B840 RS12115
gene id: 1224162:B840_RS12115
uniprot id: A0A0B6TWR4
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS00620
gene id: 1224162:B840_RS00620
uniprot id: A0A0B6TCT9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1224162:B840 RS11640
gene id: 1224162:B840_RS11640
uniprot id: A0A0B6TPW9
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

1224162:B840 RS08920
gene id: 1224162:B840_RS08920
uniprot id: A0A0B6TT45
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS01225
gene id: 1224162:B840_RS01225
uniprot id: A0A0B6TD96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1224162:B840 RS09225
gene id: 1224162:B840_RS09225
uniprot id: A0A0B6TV48
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1224162:B840 RS09360
gene id: 1224162:B840_RS09360
uniprot id: A0A0B6THR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1224162:B840 RS02230
gene id: 1224162:B840_RS02230
uniprot id: A0A0B6TR63
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1224162:B840 RS09545
gene id: 1224162:B840_RS09545
uniprot id: A0A0B6TVA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS00900
gene id: 1224162:B840_RS00900
uniprot id: A0A0B6TD06
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS09625
gene id: 1224162:B840_RS09625
uniprot id: A0A0B6TVB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1224162:B840 RS06025
gene id: 1224162:B840_RS06025
uniprot id: A0A0B6TFT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

1224162:B840 RS07405
gene id: 1224162:B840_RS07405
uniprot id: A0A0B6TS40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

1224162:B840 RS12720
gene id: 1224162:B840_RS12720
uniprot id: A0A0B6TJQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1224162:B840 RS01710
gene id: 1224162:B840_RS01710
uniprot id: A0A0B6TDH6
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1224162:B840 RS02920
gene id: 1224162:B840_RS02920
uniprot id: A0A0B6TRK4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

1224162:B840 RS05435
gene id: 1224162:B840_RS05435
uniprot id: A0A0B6TVE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1224162:B840 RS08040
gene id: 1224162:B840_RS08040
uniprot id: A0A0B6TGX3
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

1224162:B840 RS06890
gene id: 1224162:B840_RS06890
uniprot id: A0A0B6TW79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

1224162:B840 RS05045
gene id: 1224162:B840_RS05045
uniprot id: A0A0B6TV58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1224162:B840 RS09460
gene id: 1224162:B840_RS09460
uniprot id: A0A0B6THS9
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

1224162:B840 RS08020
gene id: 1224162:B840_RS08020
uniprot id: A0A0B6TMQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1224162:B840 RS01640
gene id: 1224162:B840_RS01640
uniprot id: A0A0B6TDG5
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

1224162:B840 RS05210
gene id: 1224162:B840_RS05210
uniprot id: A0A0B6TQX1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1224162:B840 RS08245
gene id: 1224162:B840_RS08245
uniprot id: A0A0B6TSN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1224162:B840 RS06255
gene id: 1224162:B840_RS06255
uniprot id: A0A0B6TTI9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1224162:B840 RS08255
gene id: 1224162:B840_RS08255
uniprot id: A0A0B6TX16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

1224162:B840 RS05830
gene id: 1224162:B840_RS05830
uniprot id: A0A0B6TR94
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS05175
gene id: 1224162:B840_RS05175
uniprot id: A0A0B6TF90
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1224162:B840 RS02460
gene id: 1224162:B840_RS02460
uniprot id: A0A0B6TRB1
names: Similarity
messages: Belongs to the peptidase C40 family.

1224162:B840 RS09700
gene id: 1224162:B840_RS09700
uniprot id: A0A0B6THW6
names: Similarity
messages: Belongs to the peptidase M1 family.

1224162:B840 RS09610
gene id: 1224162:B840_RS09610
uniprot id: A0A0B6THV3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1224162:B840 RS00635
gene id: 1224162:B840_RS00635
uniprot id: A0A0B6TQ86
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS02415
gene id: 1224162:B840_RS02415
uniprot id: A0A0B6TTM4
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1224162:B840 RS08495
gene id: 1224162:B840_RS08495
uniprot id: A0A0B6TUS4
names: Similarity
messages: Belongs to the glutamine synthetase family.

1224162:B840 RS01635
gene id: 1224162:B840_RS01635
uniprot id: A0A0B6TT91
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

1224162:B840 RS10155
gene id: 1224162:B840_RS10155
uniprot id: A0A0B6TNZ4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1224162:B840 RS07835
gene id: 1224162:B840_RS07835
uniprot id: A0A0B6TWQ5
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

1224162:B840 RS04980
gene id: 1224162:B840_RS04980
uniprot id: A0A0B6TKX9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS06525
gene id: 1224162:B840_RS06525
uniprot id: A0A0B6TLX1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1224162:B840 RS07725
gene id: 1224162:B840_RS07725
uniprot id: A0A0B6TSA8
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1224162:B840 RS00975
gene id: 1224162:B840_RS00975
uniprot id: A0A0B6TNL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1224162:B840 RS02550
gene id: 1224162:B840_RS02550
uniprot id: A0A0B6TJM0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1224162:B840 RS05775
gene id: 1224162:B840_RS05775
uniprot id: A0A0B6TT75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1224162:B840 RS03255
gene id: 1224162:B840_RS03255
uniprot id: A0A0B6TPW8
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS07505
gene id: 1224162:B840_RS07505
uniprot id: A0A0B6TS61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1224162:B840 RS01310
gene id: 1224162:B840_RS01310
uniprot id: A0A0B6TJ09
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1224162:B840 RS08170
gene id: 1224162:B840_RS08170
uniprot id: A0A0B6TSL4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1224162:B840 RS02885
gene id: 1224162:B840_RS02885
uniprot id: A0A0B6TRJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

1224162:B840 RS02210
gene id: 1224162:B840_RS02210
uniprot id: A0A0B6TDS0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1224162:B840 RS07175
gene id: 1224162:B840_RS07175
uniprot id: A0A0B6TM74
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1224162:B840 RS04655
gene id: 1224162:B840_RS04655
uniprot id: A0A0B6TKR6
names: Similarity
messages: Belongs to the D-glutamate cyclase family.

1224162:B840 RS02385
gene id: 1224162:B840_RS02385
uniprot id: A0A0B6TR96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1224162:B840 RS12560
gene id: 1224162:B840_RS12560
uniprot id: A0A0B6TQG3
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS02490
gene id: 1224162:B840_RS02490
uniprot id: A0A0B6TTN8
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

1224162:B840 RS05035
gene id: 1224162:B840_RS05035
uniprot id: A0A0B6TQT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1224162:B840 RS11145
gene id: 1224162:B840_RS11145
uniprot id: A0A0B6TPP2
names: Similarity
messages: Belongs to the OsmC/Ohr family.

1224162:B840 RS06205
gene id: 1224162:B840_RS06205
uniprot id: A0A0B6TTI1
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
messages: Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
messages: The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.

1224162:B840 RS11070
gene id: 1224162:B840_RS11070
uniprot id: A0A0B6TPK0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

1224162:B840 RS11045
gene id: 1224162:B840_RS11045
uniprot id: A0A0B6TPJ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1224162:B840 RS05745
gene id: 1224162:B840_RS05745
uniprot id: A0A0B6TR77
names: Caution
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

1224162:B840 RS02065
gene id: 1224162:B840_RS02065
uniprot id: A0A0B6TJD3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1224162:B840 RS09425
gene id: 1224162:B840_RS09425
uniprot id: A0A0B6TV76
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1224162:B840 RS02190
gene id: 1224162:B840_RS02190
uniprot id: A0A0B6TJF9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1224162:B840 RS04865
gene id: 1224162:B840_RS04865
uniprot id: A0A0B6TSM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1224162:B840 RS05055
gene id: 1224162:B840_RS05055
uniprot id: A0A0B6TKZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

1224162:B840 RS05920
gene id: 1224162:B840_RS05920
uniprot id: A0A0B6TFQ4
names: Subcellular Location Annotation
messages: Secreted

1224162:B840 RS03930
gene id: 1224162:B840_RS03930
uniprot id: A0A0B6TS82
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS09575
gene id: 1224162:B840_RS09575
uniprot id: A0A0B6TXT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

1224162:B840 RS00515
gene id: 1224162:B840_RS00515
uniprot id: A0A0B6TSJ6
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS02180
gene id: 1224162:B840_RS02180
uniprot id: A0A0B6TTI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1224162:B840 RS01750
gene id: 1224162:B840_RS01750
uniprot id: A0A0B6TQW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1224162:B840 RS04300
gene id: 1224162:B840_RS04300
uniprot id: A0A0B6TQF4
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS11305
gene id: 1224162:B840_RS11305
uniprot id: A0A0B6TYX5
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1224162:B840 RS01035
gene id: 1224162:B840_RS01035
uniprot id: A0A0B6TIX0
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

1224162:B840 RS06785
gene id: 1224162:B840_RS06785
uniprot id: A0A0B6TTR3
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS10175
gene id: 1224162:B840_RS10175
uniprot id: A0A0B6TI58
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

1224162:B840 RS12525
gene id: 1224162:B840_RS12525
uniprot id: A0A0B6TZK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

1224162:B840 RS01865
gene id: 1224162:B840_RS01865
uniprot id: A0A0B6TJ96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1224162:B840 RS12270
gene id: 1224162:B840_RS12270
uniprot id: A0A0B6TZC8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1224162:B840 RS06665
gene id: 1224162:B840_RS06665
uniprot id: A0A0B6TW41
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS10235
gene id: 1224162:B840_RS10235
uniprot id: A0A0B6TI66
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1224162:B840 RS10810
gene id: 1224162:B840_RS10810
uniprot id: A0A0B6TW09
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1224162:B840 RS05600
gene id: 1224162:B840_RS05600
uniprot id: A0A0B6TLC3
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS05020
gene id: 1224162:B840_RS05020
uniprot id: A0A0B6TV53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1224162:B840 RS12425
gene id: 1224162:B840_RS12425
uniprot id: A0A0B6TJI3
names: Subcellular Location Annotation
messages: Cytoplasm

1224162:B840 RS00235
gene id: 1224162:B840_RS00235
uniprot id: A0A0B6TCL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

1224162:B840 RS06765
gene id: 1224162:B840_RS06765
uniprot id: A0A0B6TW58
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1224162:B840 RS06445
gene id: 1224162:B840_RS06445
uniprot id: A0A0B6TG10
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

1224162:B840 RS13785
gene id: 1224162:B840_RS13785
uniprot id: A0A0B6TSV2
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS10950
gene id: 1224162:B840_RS10950
uniprot id: A0A0B6TU70
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS03725
gene id: 1224162:B840_RS03725
uniprot id: A0A0B6TUI7
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

1224162:B840 RS00025
gene id: 1224162:B840_RS00025
uniprot id: A0A0B6TPW6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1224162:B840 RS00950
gene id: 1224162:B840_RS00950
uniprot id: A0A0B6TQG9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

1224162:B840 RS04990
gene id: 1224162:B840_RS04990
uniprot id: A0A0B6TSP9
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1224162:B840 RS01700
gene id: 1224162:B840_RS01700
uniprot id: A0A0B6TQV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1224162:B840 RS08735
gene id: 1224162:B840_RS08735
uniprot id: A0A0B6TT19
names: Cofactor
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Divalent metal ions. Mg(2+) is the most effective.

1224162:B840 RS06225
gene id: 1224162:B840_RS06225
uniprot id: A0A0B6TRJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

1224162:B840 RS09690
gene id: 1224162:B840_RS09690
uniprot id: A0A0B6TVC4
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1224162:B840 RS05700
gene id: 1224162:B840_RS05700
uniprot id: A0A0B6TT55
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1224162:B840 RS00195
gene id: 1224162:B840_RS00195
uniprot id: A0A0B6TPZ7
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1224162:B840 RS00295
gene id: 1224162:B840_RS00295
uniprot id: A0A0B6TI95
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS04620
gene id: 1224162:B840_RS04620
uniprot id: A0A0B6TUX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Membrane

1224162:B840 RS04265
gene id: 1224162:B840_RS04265
uniprot id: A0A0B6TES7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCCT transporter (TC 2.A.15) family.
messages: Membrane

1224162:B840 RS12400
gene id: 1224162:B840_RS12400
uniprot id: A0A0B6TUZ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

1224162:B840 RS12405
gene id: 1224162:B840_RS12405
uniprot id: A0A0B6TWZ9
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

1224162:B840 RS11530
gene id: 1224162:B840_RS11530
uniprot id: A0A0B6TZ06
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

1224162:B840 RS03900
gene id: 1224162:B840_RS03900
uniprot id: A0A0B6TQ92
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS07595
gene id: 1224162:B840_RS07595
uniprot id: A0A0B6TMF8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1224162:B840 RS02485
gene id: 1224162:B840_RS02485
uniprot id: A0A0B6TRB7
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1224162:B840 RS04445
gene id: 1224162:B840_RS04445
uniprot id: A0A0B6TSF3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MshB deacetylase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.

1224162:B840 RS11400
gene id: 1224162:B840_RS11400
uniprot id: A0A0B6TUG4
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS00085
gene id: 1224162:B840_RS00085
uniprot id: A0A0B6TPX7
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS01555
gene id: 1224162:B840_RS01555
uniprot id: A0A0B6TQT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.
messages: Cell membrane
messages: Membrane

1224162:B840 RS06260
gene id: 1224162:B840_RS06260
uniprot id: A0A0B6TVY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1224162:B840 RS08380
gene id: 1224162:B840_RS08380
uniprot id: A0A0B6TH60
names: Similarity
messages: Belongs to the peptidase C40 family.

1224162:B840 RS00445
gene id: 1224162:B840_RS00445
uniprot id: A0A0B6TID0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1224162:B840 RS07710
gene id: 1224162:B840_RS07710
uniprot id: A0A0B6TWM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1224162:B840 RS08060
gene id: 1224162:B840_RS08060
uniprot id: A0A0B6TWW0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1224162:B840 RS00465
gene id: 1224162:B840_RS00465
uniprot id: A0A0B6TCQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

1224162:B840 RS07555
gene id: 1224162:B840_RS07555
uniprot id: A0A0B6TU39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1224162:B840 RS05770
gene id: 1224162:B840_RS05770
uniprot id: A0A0B6TR82
names: Similarity
messages: Belongs to the UPF0434 family.

1224162:B840 RS06165
gene id: 1224162:B840_RS06165
uniprot id: A0A0B6TFW8
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

1224162:B840 RS02855
gene id: 1224162:B840_RS02855
uniprot id: A0A0B6TPM2
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS07315
gene id: 1224162:B840_RS07315
uniprot id: A0A0B6TWE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1224162:B840 RS05220
gene id: 1224162:B840_RS05220
uniprot id: A0A0B6TV97
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

1224162:B840 RS04210
gene id: 1224162:B840_RS04210
uniprot id: A0A0B6TUR0
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

1224162:B840 RS04415
gene id: 1224162:B840_RS04415
uniprot id: A0A0B6TKM4
names: Similarity
messages: Belongs to the ArsC family.

1224162:B840 RS04190
gene id: 1224162:B840_RS04190
uniprot id: A0A0B6TUQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

1224162:B840 RS02240
gene id: 1224162:B840_RS02240
uniprot id: A0A0B6TDS5
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS01540
gene id: 1224162:B840_RS01540
uniprot id: A0A0B6TDE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1224162:B840 RS05065
gene id: 1224162:B840_RS05065
uniprot id: A0A0B6TSR4
names: Similarity
messages: Belongs to the UPF0045 family.

1224162:B840 RS03160
gene id: 1224162:B840_RS03160
uniprot id: A0A0B6TU44
names: Similarity
messages: Belongs to the citrate synthase family.

1224162:B840 RS06860
gene id: 1224162:B840_RS06860
uniprot id: A0A0B6TTS5
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1224162:B840 RS05635
gene id: 1224162:B840_RS05635
uniprot id: A0A0B6TVI9
names: Similarity
messages: Belongs to the universal stress protein A family.

1224162:B840 RS01075
gene id: 1224162:B840_RS01075
uniprot id: A0A0B6TSY3
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS01960
gene id: 1224162:B840_RS01960
uniprot id: A0A0B6TDM5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1224162:B840 RS07910
gene id: 1224162:B840_RS07910
uniprot id: A0A0B6TWS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS12480
gene id: 1224162:B840_RS12480
uniprot id: A0A0B6TJJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1224162:B840 RS12050
gene id: 1224162:B840_RS12050
uniprot id: A0A0B6TZ85
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS12440
gene id: 1224162:B840_RS12440
uniprot id: A0A0B6TX09
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1224162:B840 RS01965
gene id: 1224162:B840_RS01965
uniprot id: A0A0B6TJB5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1224162:B840 RS11200
gene id: 1224162:B840_RS11200
uniprot id: A0A0B6TUD8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1224162:B840 RS05885
gene id: 1224162:B840_RS05885
uniprot id: A0A0B6TT99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1224162:B840 RS04965
gene id: 1224162:B840_RS04965
uniprot id: A0A0B6TSP4
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1224162:B840 RS10490
gene id: 1224162:B840_RS10490
uniprot id: A0A0B6TYA9
names: Similarity
messages: Belongs to the glutathione peroxidase family.

1224162:B840 RS10705
gene id: 1224162:B840_RS10705
uniprot id: A0A0B6TIE9
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.
messages: Reversible hydration of carbon dioxide.

1224162:B840 RS05105
gene id: 1224162:B840_RS05105
uniprot id: A0A0B6TL04
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1224162:B840 RS09740
gene id: 1224162:B840_RS09740
uniprot id: A0A0B6TTH1
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group II subfamily.

1224162:B840 RS07640
gene id: 1224162:B840_RS07640
uniprot id: A0A0B6TGN5
names: Similarity
messages: Belongs to the MQO family.

1224162:B840 RS01170
gene id: 1224162:B840_RS01170
uniprot id: A0A0B6TSZ5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1224162:B840 RS02925
gene id: 1224162:B840_RS02925
uniprot id: A0A0B6TTZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

1224162:B840 RS09530
gene id: 1224162:B840_RS09530
uniprot id: A0A0B6THU2
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

1224162:B840 RS00940
gene id: 1224162:B840_RS00940
uniprot id: A0A0B6TIQ7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS01585
gene id: 1224162:B840_RS01585
uniprot id: A0A0B6TT82
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS11250
gene id: 1224162:B840_RS11250
uniprot id: A0A0B6TUE4
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

1224162:B840 RS03010
gene id: 1224162:B840_RS03010
uniprot id: A0A0B6TJW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224162:B840 RS06240
gene id: 1224162:B840_RS06240
uniprot id: A0A0B6TFX8
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

1224162:B840 RS04880
gene id: 1224162:B840_RS04880
uniprot id: A0A0B6TKV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1224162:B840 RS08610
gene id: 1224162:B840_RS08610
uniprot id: A0A0B6TUX1
names: Similarity
messages: Belongs to the glutamine synthetase family.

1224162:B840 RS11955
gene id: 1224162:B840_RS11955
uniprot id: A0A0B6TJ67
names: Similarity
messages: Belongs to the FPG family.

1224162:B840 RS02800
gene id: 1224162:B840_RS02800
uniprot id: A0A0B6TJS0
names: Similarity
messages: Belongs to the DEAD box helicase family.

1224162:B840 RS06215
gene id: 1224162:B840_RS06215
uniprot id: A0A0B6TFX3
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.

1224162:B840 RS07615
gene id: 1224162:B840_RS07615
uniprot id: A0A0B6TGN0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1224162:B840 RS03260
gene id: 1224162:B840_RS03260
uniprot id: A0A0B6TRU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1224162:B840 RS05205
gene id: 1224162:B840_RS05205
uniprot id: A0A0B6TL27
names: Similarity
messages: Belongs to the PrpF family.

1224162:B840 RS00365
gene id: 1224162:B840_RS00365
uniprot id: A0A0B6TCN6
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

1224162:B840 RS07845
gene id: 1224162:B840_RS07845
uniprot id: A0A0B6TML6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1224162:B840 RS01415
gene id: 1224162:B840_RS01415
uniprot id: A0A0B6TQR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1224162:B840 RS09215
gene id: 1224162:B840_RS09215
uniprot id: A0A0B6TNH7
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.

1224162:B840 RS11945
gene id: 1224162:B840_RS11945
uniprot id: A0A0B6TWN7
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

1224162:B840 RS10725
gene id: 1224162:B840_RS10725
uniprot id: A0A0B6TPB4
names: Function
names: Similarity
messages: Belongs to the IMPDH/GMPR family. GuaB1 subfamily.
messages: Involved in the purine-salvage pathway. Catalyzes the NADPH-dependent conversion of GMP to IMP.

1224162:B840 RS10360
gene id: 1224162:B840_RS10360
uniprot id: A0A0B6TVP7
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

1224162:B840 RS00535
gene id: 1224162:B840_RS00535
uniprot id: A0A0B6TQ62
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

1224162:B840 RS05010
gene id: 1224162:B840_RS05010
uniprot id: A0A0B6TQS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1224162:B840 RS00690
gene id: 1224162:B840_RS00690
uniprot id: A0A0B6TSN1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1224162:B840 RS10505
gene id: 1224162:B840_RS10505
uniprot id: A0A0B6TTW6
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1224162:B840 RS00215
gene id: 1224162:B840_RS00215
uniprot id: A0A0B6TN35
names: Subcellular Location Annotation
messages: Cytoplasm

1224162:B840 RS06650
gene id: 1224162:B840_RS06650
uniprot id: A0A0B6TLZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1224162:B840 RS00455
gene id: 1224162:B840_RS00455
uniprot id: A0A0B6TQ48
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.

1224162:B840 RS12840
gene id: 1224162:B840_RS12840
uniprot id: A0A0B6TSB7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1224162:B840 RS07475
gene id: 1224162:B840_RS07475
uniprot id: A0A0B6TMD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

1224162:B840 RS02755
gene id: 1224162:B840_RS02755
uniprot id: A0A0B6TPK1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1224162:B840 RS05170
gene id: 1224162:B840_RS05170
uniprot id: A0A0B6TV84
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1224162:B840 RS00290
gene id: 1224162:B840_RS00290
uniprot id: A0A0B6TCM4
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS01005
gene id: 1224162:B840_RS01005
uniprot id: A0A0B6TQJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

1224162:B840 RS02945
gene id: 1224162:B840_RS02945
uniprot id: A0A0B6TRL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1224162:B840 RS07465
gene id: 1224162:B840_RS07465
uniprot id: A0A0B6TWI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.
messages: Membrane

1224162:B840 RS07620
gene id: 1224162:B840_RS07620
uniprot id: A0A0B6TMG5
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

1224162:B840 RS05145
gene id: 1224162:B840_RS05145
uniprot id: A0A0B6TV80
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS07270
gene id: 1224162:B840_RS07270
uniprot id: A0A0B6TGF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

1224162:B840 RS02840
gene id: 1224162:B840_RS02840
uniprot id: A0A0B6TTX3
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1224162:B840 RS10450
gene id: 1224162:B840_RS10450
uniprot id: A0A0B6TP46
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1224162:B840 RS07775
gene id: 1224162:B840_RS07775
uniprot id: A0A0B6TSB9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1224162:B840 RS04530
gene id: 1224162:B840_RS04530
uniprot id: A0A0B6TKP6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS12635
gene id: 1224162:B840_RS12635
uniprot id: A0A0B6TQI0
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

1224162:B840 RS10195
gene id: 1224162:B840_RS10195
uniprot id: A0A0B6TY48
names: Similarity
messages: Belongs to the fructosamine kinase family.

1224162:B840 RS06645
gene id: 1224162:B840_RS06645
uniprot id: A0A0B6TG49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1224162:B840 RS07500
gene id: 1224162:B840_RS07500
uniprot id: A0A0B6TMD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1224162:B840 RS08415
gene id: 1224162:B840_RS08415
uniprot id: A0A0B6TSS8
names: Similarity
messages: Belongs to the asparagine synthetase family.

1224162:B840 RS08285
gene id: 1224162:B840_RS08285
uniprot id: A0A0B6TH33
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS09555
gene id: 1224162:B840_RS09555
uniprot id: A0A0B6THU6
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS06275
gene id: 1224162:B840_RS06275
uniprot id: A0A0B6TRK2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
messages: Monomer.

1224162:B840 RS01535
gene id: 1224162:B840_RS01535
uniprot id: A0A0B6TT72
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1224162:B840 RS04195
gene id: 1224162:B840_RS04195
uniprot id: A0A0B6TKI9
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS01185
gene id: 1224162:B840_RS01185
uniprot id: A0A0B6TNS1
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS02380
gene id: 1224162:B840_RS02380
uniprot id: A0A0B6TPC4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS08895
gene id: 1224162:B840_RS08895
uniprot id: A0A0B6TT43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

1224162:B840 RS05740
gene id: 1224162:B840_RS05740
uniprot id: A0A0B6TLG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1224162:B840 RS05805
gene id: 1224162:B840_RS05805
uniprot id: A0A0B6TR88
names: Similarity
messages: Belongs to the TlyA family.

1224162:B840 RS08745
gene id: 1224162:B840_RS08745
uniprot id: A0A0B6TXG4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

1224162:B840 RS01890
gene id: 1224162:B840_RS01890
uniprot id: A0A0B6TJA1
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1224162:B840 RS08175
gene id: 1224162:B840_RS08175
uniprot id: A0A0B6TUI1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1224162:B840 RS11900
gene id: 1224162:B840_RS11900
uniprot id: A0A0B6TZ57
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

1224162:B840 RS03565
gene id: 1224162:B840_RS03565
uniprot id: A0A0B6TK99
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1224162:B840 RS13855
gene id: 1224162:B840_RS13855
uniprot id: A0A0B6TVX9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1224162:B840 RS11000
gene id: 1224162:B840_RS11000
uniprot id: A0A0B6TU80
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1224162:B840 RS01025
gene id: 1224162:B840_RS01025
uniprot id: A0A0B6TSX8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

1224162:B840 RS06415
gene id: 1224162:B840_RS06415
uniprot id: A0A0B6TW03
names: Subcellular Location Annotation
messages: Cell membrane

1224162:B840 RS03155
gene id: 1224162:B840_RS03155
uniprot id: A0A0B6TRS0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

1224162:B840 RS00435
gene id: 1224162:B840_RS00435
uniprot id: A0A0B6TSH7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1224162:B840 RS04550
gene id: 1224162:B840_RS04550
uniprot id: A0A0B6TEX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1224162:B840 RS12485
gene id: 1224162:B840_RS12485
uniprot id: A0A0B6TQE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane

1224162:B840 RS00555
gene id: 1224162:B840_RS00555
uniprot id: A0A0B6TNA9
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

1224162:B840 RS11235
gene id: 1224162:B840_RS11235
uniprot id: A0A0B6TYW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1224162:B840 RS07415
gene id: 1224162:B840_RS07415
uniprot id: A0A0B6TWG9
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS06740
gene id: 1224162:B840_RS06740
uniprot id: A0A0B6TW54
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

1224162:B840 RS04120
gene id: 1224162:B840_RS04120
uniprot id: A0A0B6TKH9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial survival in phagocytes.

1224162:B840 RS08470
gene id: 1224162:B840_RS08470
uniprot id: A0A0B6TUR8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

1224162:B840 RS02785
gene id: 1224162:B840_RS02785
uniprot id: A0A0B6TRH8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1224162:B840 RS07745
gene id: 1224162:B840_RS07745
uniprot id: A0A0B6TMJ6
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1224162:B840 RS07670
gene id: 1224162:B840_RS07670
uniprot id: A0A0B6TMH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1224162:B840 RS01910
gene id: 1224162:B840_RS01910
uniprot id: A0A0B6TDL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1224162:B840 RS07375
gene id: 1224162:B840_RS07375
uniprot id: A0A0B6TMB0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1224162:B840 RS02615
gene id: 1224162:B840_RS02615
uniprot id: A0A0B6TTR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224162:B840 RS03965
gene id: 1224162:B840_RS03965
uniprot id: A0A0B6TEN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1224162:B840 RS08110
gene id: 1224162:B840_RS08110
uniprot id: A0A0B6TGZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

1224162:B840 RS08275
gene id: 1224162:B840_RS08275
uniprot id: A0A0B6TUL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1224162:B840 RS08440
gene id: 1224162:B840_RS08440
uniprot id: A0A0B6TST4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

1224162:B840 RS01875
gene id: 1224162:B840_RS01875
uniprot id: A0A0B6TQZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1224162:B840 RS05430
gene id: 1224162:B840_RS05430
uniprot id: A0A0B6TSY7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1224162:B840 RS11800
gene id: 1224162:B840_RS11800
uniprot id: A0A0B6TPZ1
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS08030
gene id: 1224162:B840_RS08030
uniprot id: A0A0B6TUE0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1224162:B840 RS04950
gene id: 1224162:B840_RS04950
uniprot id: A0A0B6TF41
names: Similarity
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Homotrimer.

1224162:B840 RS00390
gene id: 1224162:B840_RS00390
uniprot id: A0A0B6TCP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1224162:B840 RS05015
gene id: 1224162:B840_RS05015
uniprot id: A0A0B6TSQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1224162:B840 RS00630
gene id: 1224162:B840_RS00630
uniprot id: A0A0B6TND1
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1224162:B840 RS12790
gene id: 1224162:B840_RS12790
uniprot id: A0A0B6TQ30
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1224162:B840 RS00880
gene id: 1224162:B840_RS00880
uniprot id: A0A0B6TQF5
names: Function
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: May catalyze the transamination reaction in phenylalanine biosynthesis.

1224162:B840 RS01950
gene id: 1224162:B840_RS01950
uniprot id: A0A0B6TR04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1224162:B840 RS04875
gene id: 1224162:B840_RS04875
uniprot id: A0A0B6TF25
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

1224162:B840 RS10655
gene id: 1224162:B840_RS10655
uniprot id: A0A0B6TID9
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1224162:B840 RS08000
gene id: 1224162:B840_RS08000
uniprot id: A0A0B6TSH4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS02720
gene id: 1224162:B840_RS02720
uniprot id: A0A0B6TE16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

1224162:B840 RS05580
gene id: 1224162:B840_RS05580
uniprot id: A0A0B6TR41
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS06825
gene id: 1224162:B840_RS06825
uniprot id: A0A0B6TM19
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1224162:B840 RS02980
gene id: 1224162:B840_RS02980
uniprot id: A0A0B6TE56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

1224162:B840 RS08475
gene id: 1224162:B840_RS08475
uniprot id: A0A0B6TX91
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1224162:B840 RS06640
gene id: 1224162:B840_RS06640
uniprot id: A0A0B6TW37
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1224162:B840 RS11275
gene id: 1224162:B840_RS11275
uniprot id: A0A0B6TUE9
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS11890
gene id: 1224162:B840_RS11890
uniprot id: A0A0B6TUN4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1224162:B840 RS12260
gene id: 1224162:B840_RS12260
uniprot id: A0A0B6TUU7
names: Similarity
messages: Belongs to the ParB family.

1224162:B840 RS12150
gene id: 1224162:B840_RS12150
uniprot id: A0A0B6TJ98
names: Function
names: Similarity
messages: Belongs to the TrpF family.
messages: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain.
messages: In the C-terminal section; belongs to the TrpF family.
messages: In the N-terminal section; belongs to the TrpC family.

1224162:B840 RS11205
gene id: 1224162:B840_RS11205
uniprot id: A0A0B6TWC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1224162:B840 RS05315
gene id: 1224162:B840_RS05315
uniprot id: A0A0B6TSW6
names: Similarity
messages: Belongs to the non-flavoprotein flavin reductase family.

1224162:B840 RS02225
gene id: 1224162:B840_RS02225
uniprot id: A0A0B6TP93
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

1224162:B840 RS00130
gene id: 1224162:B840_RS00130
uniprot id: A0A0B6TI68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

1224162:B840 RS04455
gene id: 1224162:B840_RS04455
uniprot id: A0A0B6TEV6
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1224162:B840 RS10830
gene id: 1224162:B840_RS10830
uniprot id: A0A0B6TU40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1224162:B840 RS06950
gene id: 1224162:B840_RS06950
uniprot id: A0A0B6TM41
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.
messages: Cell membrane
messages: Contains a di-nuclear catalytic Mg(2+) center.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1224162:B840 RS06575
gene id: 1224162:B840_RS06575
uniprot id: A0A0B6TLX8
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1224162:B840 RS10390
gene id: 1224162:B840_RS10390
uniprot id: A0A0B6TY80
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1224162:B840 RS05735
gene id: 1224162:B840_RS05735
uniprot id: A0A0B6TFK8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1224162:B840 RS01840
gene id: 1224162:B840_RS01840
uniprot id: A0A0B6TJ92
names: Similarity
messages: Belongs to the asp23 family.

1224162:B840 RS03695
gene id: 1224162:B840_RS03695
uniprot id: A0A0B6TS49
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS01650
gene id: 1224162:B840_RS01650
uniprot id: A0A0B6TNZ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

1224162:B840 RS07650
gene id: 1224162:B840_RS07650
uniprot id: A0A0B6TS91
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1224162:B840 RS09320
gene id: 1224162:B840_RS09320
uniprot id: A0A0B6TTA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1224162:B840 RS09565
gene id: 1224162:B840_RS09565
uniprot id: A0A0B6TTE7
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1224162:B840 RS02000
gene id: 1224162:B840_RS02000
uniprot id: A0A0B6TR27
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1224162:B840 RS13380
gene id: 1224162:B840_RS13380
uniprot id: A0A0B6TCK3
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS06010
gene id: 1224162:B840_RS06010
uniprot id: A0A0B6TRE1
names: Subcellular Location Annotation
messages: Membrane

1224162:B840 RS06505
gene id: 1224162:B840_RS06505
uniprot id: A0A0B6TRN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1224162:B840 RS10075
gene id: 1224162:B840_RS10075
uniprot id: A0A0B6TI38
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1224162:B840 RS06815
gene id: 1224162:B840_RS06815
uniprot id: A0A0B6TW67
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1224162:B840 RS06720
gene id: 1224162:B840_RS06720
uniprot id: A0A0B6TG62
names: Similarity
messages: Belongs to the peptidase M24B family.

1224162:B840 RS05755
gene id: 1224162:B840_RS05755
uniprot id: A0A0B6TVM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

1224162:B840 RS03945
gene id: 1224162:B840_RS03945
uniprot id: A0A0B6TKE2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1224162:B840 RS10185
gene id: 1224162:B840_RS10185
uniprot id: A0A0B6TTQ4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1224162:B840 RS11610
gene id: 1224162:B840_RS11610
uniprot id: A0A0B6TJ04
names: Similarity
messages: Belongs to the pyruvate kinase family.

1224162:B840 RS04970
gene id: 1224162:B840_RS04970
uniprot id: A0A0B6TV44
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

1224162:B840 RS07850
gene id: 1224162:B840_RS07850
uniprot id: A0A0B6TSD9
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.