1223802:SUTH RS20200
gene id: 1223802:SUTH_RS20200
uniprot id: W0SCP0
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1223802:SUTH RS04120
gene id: 1223802:SUTH_RS04120
uniprot id: W0SC64
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

1223802:SUTH RS17590
gene id: 1223802:SUTH_RS17590
uniprot id: W0SKC3
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS12375
gene id: 1223802:SUTH_RS12375
uniprot id: W0SH31
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

1223802:SUTH RS15290
gene id: 1223802:SUTH_RS15290
uniprot id: W0SHI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1223802:SUTH RS11850
gene id: 1223802:SUTH_RS11850
uniprot id: W0SGK0
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

1223802:SUTH RS07810
gene id: 1223802:SUTH_RS07810
uniprot id: W0SEA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1223802:SUTH RS01655
gene id: 1223802:SUTH_RS01655
uniprot id: W0SAW6
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1223802:SUTH RS00905
gene id: 1223802:SUTH_RS00905
uniprot id: W0S9X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1223802:SUTH RS08020
gene id: 1223802:SUTH_RS08020
uniprot id: W0SEE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1223802:SUTH RS15075
gene id: 1223802:SUTH_RS15075
uniprot id: W0SJH9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1223802:SUTH RS11280
gene id: 1223802:SUTH_RS11280
uniprot id: W0SGI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

1223802:SUTH RS16495
gene id: 1223802:SUTH_RS16495
uniprot id: W0SI27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1223802:SUTH RS11415
gene id: 1223802:SUTH_RS11415
uniprot id: W0SFP0
names: Similarity
messages: Belongs to the HSP15 family.

1223802:SUTH RS11575
gene id: 1223802:SUTH_RS11575
uniprot id: W0SFS0
names: Similarity
messages: Belongs to the ComB family.

1223802:SUTH RS05920
gene id: 1223802:SUTH_RS05920
uniprot id: W0SD62
names: Cofactor
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

1223802:SUTH RS15245
gene id: 1223802:SUTH_RS15245
uniprot id: W0SJN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1223802:SUTH RS03215
gene id: 1223802:SUTH_RS03215
uniprot id: W0SBQ8
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1223802:SUTH RS16145
gene id: 1223802:SUTH_RS16145
uniprot id: W0SMI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1223802:SUTH RS00535
gene id: 1223802:SUTH_RS00535
uniprot id: W0S9R3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiV subfamily.
messages: Forms an heterodimer with UbiU.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiU, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

1223802:SUTH RS03420
gene id: 1223802:SUTH_RS03420
uniprot id: W0SBU3
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

1223802:SUTH RS15125
gene id: 1223802:SUTH_RS15125
uniprot id: W0SJI5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1223802:SUTH RS05530
gene id: 1223802:SUTH_RS05530
uniprot id: W0SGT7
names: Caution
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

1223802:SUTH RS13455
gene id: 1223802:SUTH_RS13455
uniprot id: W0SL26
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1223802:SUTH RS11815
gene id: 1223802:SUTH_RS11815
uniprot id: W0SFW1
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS15325
gene id: 1223802:SUTH_RS15325
uniprot id: W0SJK0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS06905
gene id: 1223802:SUTH_RS06905
uniprot id: W0SEI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1223802:SUTH RS10050
gene id: 1223802:SUTH_RS10050
uniprot id: W0SFL6
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

1223802:SUTH RS04930
gene id: 1223802:SUTH_RS04930
uniprot id: W0SD12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

1223802:SUTH RS13280
gene id: 1223802:SUTH_RS13280
uniprot id: W0SKP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1223802:SUTH RS05140
gene id: 1223802:SUTH_RS05140
uniprot id: W0SCU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1223802:SUTH RS04785
gene id: 1223802:SUTH_RS04785
uniprot id: W0SCV6
names: Similarity
messages: Belongs to the type III secretion exporter family.

1223802:SUTH RS03210
gene id: 1223802:SUTH_RS03210
uniprot id: W0SCH2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS08935
gene id: 1223802:SUTH_RS08935
uniprot id: W0SFP3
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1223802:SUTH RS10915
gene id: 1223802:SUTH_RS10915
uniprot id: W0SGV5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1223802:SUTH RS11640
gene id: 1223802:SUTH_RS11640
uniprot id: W0SGQ5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1223802:SUTH RS01570
gene id: 1223802:SUTH_RS01570
uniprot id: W0SA81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1223802:SUTH RS14150
gene id: 1223802:SUTH_RS14150
uniprot id: W0SIE4
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1223802:SUTH RS01620
gene id: 1223802:SUTH_RS01620
uniprot id: W0SA91
names: Similarity
messages: Belongs to the thioesterase PaaI family.

1223802:SUTH RS02835
gene id: 1223802:SUTH_RS02835
uniprot id: W0SBV8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

1223802:SUTH RS07790
gene id: 1223802:SUTH_RS07790
uniprot id: W0SEL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1223802:SUTH RS16330
gene id: 1223802:SUTH_RS16330
uniprot id: W0SJ54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1223802:SUTH RS05555
gene id: 1223802:SUTH_RS05555
uniprot id: W0SGU2
names: Similarity
messages: Belongs to the UPF0234 family.

1223802:SUTH RS05655
gene id: 1223802:SUTH_RS05655
uniprot id: W0SGW5
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS14485
gene id: 1223802:SUTH_RS14485
uniprot id: W0SLM9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: Homotetramer.
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

1223802:SUTH RS05150
gene id: 1223802:SUTH_RS05150
uniprot id: W0SGM2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1223802:SUTH RS10200
gene id: 1223802:SUTH_RS10200
uniprot id: W0SFQ7
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

1223802:SUTH RS05480
gene id: 1223802:SUTH_RS05480
uniprot id: W0SCH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

1223802:SUTH RS05800
gene id: 1223802:SUTH_RS05800
uniprot id: W0SDF8
names: Similarity
messages: Belongs to the transglycosylase Slt family.

1223802:SUTH RS01720
gene id: 1223802:SUTH_RS01720
uniprot id: W0SAA9
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS07675
gene id: 1223802:SUTH_RS07675
uniprot id: W0SEJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.

1223802:SUTH RS11835
gene id: 1223802:SUTH_RS11835
uniprot id: W0SJC7
names: Similarity
messages: Belongs to the aspartokinase family.

1223802:SUTH RS13705
gene id: 1223802:SUTH_RS13705
uniprot id: W0SI77
names: Function
names: Similarity
messages: Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

1223802:SUTH RS03260
gene id: 1223802:SUTH_RS03260
uniprot id: W0SCI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1223802:SUTH RS16610
gene id: 1223802:SUTH_RS16610
uniprot id: W0SJ78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

1223802:SUTH RS14890
gene id: 1223802:SUTH_RS14890
uniprot id: W0SHD2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1223802:SUTH RS04105
gene id: 1223802:SUTH_RS04105
uniprot id: W0SFY1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1223802:SUTH RS12440
gene id: 1223802:SUTH_RS12440
uniprot id: W0SG75
names: Similarity
messages: Belongs to the hemerythrin family.

1223802:SUTH RS08685
gene id: 1223802:SUTH_RS08685
uniprot id: W0SEZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1223802:SUTH RS03400
gene id: 1223802:SUTH_RS03400
uniprot id: W0SC46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1223802:SUTH RS10505
gene id: 1223802:SUTH_RS10505
uniprot id: W0SF74
names: Cofactor
messages: Binds 1 heme c group covalently per subunit.

1223802:SUTH RS13420
gene id: 1223802:SUTH_RS13420
uniprot id: W0SIQ3
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS14025
gene id: 1223802:SUTH_RS14025
uniprot id: W0SIC5
names: Similarity
messages: Belongs to the extradiol ring-cleavage dioxygenase family.

1223802:SUTH RS16245
gene id: 1223802:SUTH_RS16245
uniprot id: W0SMK1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1223802:SUTH RS16365
gene id: 1223802:SUTH_RS16365
uniprot id: W0SI05
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

1223802:SUTH RS12675
gene id: 1223802:SUTH_RS12675
uniprot id: W0SHT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1223802:SUTH RS14195
gene id: 1223802:SUTH_RS14195
uniprot id: W0SI74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

1223802:SUTH RS15735
gene id: 1223802:SUTH_RS15735
uniprot id: W0SJT5
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1223802:SUTH RS10835
gene id: 1223802:SUTH_RS10835
uniprot id: W0SFD4
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1223802:SUTH RS01300
gene id: 1223802:SUTH_RS01300
uniprot id: W0SA40
names: Similarity
messages: Belongs to the UPF0235 family.

1223802:SUTH RS13160
gene id: 1223802:SUTH_RS13160
uniprot id: W0SGL1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1223802:SUTH RS15720
gene id: 1223802:SUTH_RS15720
uniprot id: W0SIY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

1223802:SUTH RS03685
gene id: 1223802:SUTH_RS03685
uniprot id: W0SBZ3
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1223802:SUTH RS15345
gene id: 1223802:SUTH_RS15345
uniprot id: W0SJQ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1223802:SUTH RS08735
gene id: 1223802:SUTH_RS08735
uniprot id: W0SET8
names: Subcellular Location Annotation
messages: Cell inner membrane

1223802:SUTH RS09900
gene id: 1223802:SUTH_RS09900
uniprot id: W0SFR2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS06510
gene id: 1223802:SUTH_RS06510
uniprot id: W0SDU4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxH family.
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.
messages: Binds 2 Mn(2+) ions per subunit in a binuclear metal center.
messages: Cell inner membrane
messages: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS09205
gene id: 1223802:SUTH_RS09205
uniprot id: W0SEH7
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

1223802:SUTH RS16820
gene id: 1223802:SUTH_RS16820
uniprot id: W0SMV5
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1223802:SUTH RS07460
gene id: 1223802:SUTH_RS07460
uniprot id: W0SHI0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1223802:SUTH RS00570
gene id: 1223802:SUTH_RS00570
uniprot id: W0SAB8
names: Similarity
messages: Belongs to the DprA/Smf family.

1223802:SUTH RS01070
gene id: 1223802:SUTH_RS01070
uniprot id: W0SBA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.

1223802:SUTH RS14910
gene id: 1223802:SUTH_RS14910
uniprot id: W0SLU8
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

1223802:SUTH RS10015
gene id: 1223802:SUTH_RS10015
uniprot id: W0SEZ4
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

1223802:SUTH RS17215
gene id: 1223802:SUTH_RS17215
uniprot id: W0SN36
names: Similarity
messages: Belongs to the CutA family.

1223802:SUTH RS05570
gene id: 1223802:SUTH_RS05570
uniprot id: W0SD02
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1223802:SUTH RS07980
gene id: 1223802:SUTH_RS07980
uniprot id: W0SHM5
names: Function
names: Similarity
messages: A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
messages: Belongs to the NifU family.

1223802:SUTH RS04470
gene id: 1223802:SUTH_RS04470
uniprot id: W0SBV5
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

1223802:SUTH RS15395
gene id: 1223802:SUTH_RS15395
uniprot id: W0SJQ4
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS05225
gene id: 1223802:SUTH_RS05225
uniprot id: W0SCC7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1223802:SUTH RS16675
gene id: 1223802:SUTH_RS16675
uniprot id: W0SK57
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1223802:SUTH RS17160
gene id: 1223802:SUTH_RS17160
uniprot id: W0SK37
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

1223802:SUTH RS17625
gene id: 1223802:SUTH_RS17625
uniprot id: W0SND4
names: Subcellular Location Annotation
messages: Nucleus

1223802:SUTH RS06125
gene id: 1223802:SUTH_RS06125
uniprot id: W0SDK9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1223802:SUTH RS17465
gene id: 1223802:SUTH_RS17465
uniprot id: W0SK79
names: Subcellular Location Annotation
messages: Cytoplasm

1223802:SUTH RS10705
gene id: 1223802:SUTH_RS10705
uniprot id: W0SFB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

1223802:SUTH RS08360
gene id: 1223802:SUTH_RS08360
uniprot id: W0SEV6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

1223802:SUTH RS05475
gene id: 1223802:SUTH_RS05475
uniprot id: W0SGS8
names: Similarity
messages: Belongs to the UPF0434 family.

1223802:SUTH RS14310
gene id: 1223802:SUTH_RS14310
uniprot id: W0SLJ4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1223802:SUTH RS03335
gene id: 1223802:SUTH_RS03335
uniprot id: W0SCJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1223802:SUTH RS10290
gene id: 1223802:SUTH_RS10290
uniprot id: W0SF38
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1223802:SUTH RS16875
gene id: 1223802:SUTH_RS16875
uniprot id: W0SI69
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS08540
gene id: 1223802:SUTH_RS08540
uniprot id: W0SHV4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase S45 family.
messages: Binds 1 Ca(2+) ion per dimer.

1223802:SUTH RS11510
gene id: 1223802:SUTH_RS11510
uniprot id: W0SGD7
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1223802:SUTH RS03220
gene id: 1223802:SUTH_RS03220
uniprot id: W0SC17
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1223802:SUTH RS06395
gene id: 1223802:SUTH_RS06395
uniprot id: W0SH74
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1223802:SUTH RS09370
gene id: 1223802:SUTH_RS09370
uniprot id: W0SFX4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-66 and Arg-69) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

1223802:SUTH RS17220
gene id: 1223802:SUTH_RS17220
uniprot id: W0SIC7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.

1223802:SUTH RS04335
gene id: 1223802:SUTH_RS04335
uniprot id: W0SG35
names: Similarity
messages: Belongs to the P(II) protein family.

1223802:SUTH RS00005
gene id: 1223802:SUTH_RS00005
uniprot id: W0SA31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1223802:SUTH RS04055
gene id: 1223802:SUTH_RS04055
uniprot id: W0SFW9
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudJ subfamily.
messages: Monomer.

1223802:SUTH RS09780
gene id: 1223802:SUTH_RS09780
uniprot id: W0SII7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1223802:SUTH RS00010
gene id: 1223802:SUTH_RS00010
uniprot id: W0SAE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1223802:SUTH RS01125
gene id: 1223802:SUTH_RS01125
uniprot id: W0SBB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

1223802:SUTH RS05415
gene id: 1223802:SUTH_RS05415
uniprot id: W0SCY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AceK family.
messages: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
messages: Cytoplasm

1223802:SUTH RS03770
gene id: 1223802:SUTH_RS03770
uniprot id: W0SFS1
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

1223802:SUTH RS13000
gene id: 1223802:SUTH_RS13000
uniprot id: W0SHY1
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

1223802:SUTH RS01855
gene id: 1223802:SUTH_RS01855
uniprot id: W0SAD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NapB family.
messages: Periplasm

1223802:SUTH RS06445
gene id: 1223802:SUTH_RS06445
uniprot id: W0SD01
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS16160
gene id: 1223802:SUTH_RS16160
uniprot id: W0SJT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1223802:SUTH RS15860
gene id: 1223802:SUTH_RS15860
uniprot id: W0SJW0
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1223802:SUTH RS03695
gene id: 1223802:SUTH_RS03695
uniprot id: W0SFQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1223802:SUTH RS12085
gene id: 1223802:SUTH_RS12085
uniprot id: W0SJE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

1223802:SUTH RS09000
gene id: 1223802:SUTH_RS09000
uniprot id: W0SI58
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1223802:SUTH RS01075
gene id: 1223802:SUTH_RS01075
uniprot id: W0SAK9
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

1223802:SUTH RS13520
gene id: 1223802:SUTH_RS13520
uniprot id: W0SIR2
names: PTM
messages: Binds 1 heme group per subunit.

1223802:SUTH RS15840
gene id: 1223802:SUTH_RS15840
uniprot id: W0SJP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

1223802:SUTH RS05820
gene id: 1223802:SUTH_RS05820
uniprot id: W0SD43
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

1223802:SUTH RS15445
gene id: 1223802:SUTH_RS15445
uniprot id: W0SJR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1223802:SUTH RS02980
gene id: 1223802:SUTH_RS02980
uniprot id: W0SB33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1223802:SUTH RS16605
gene id: 1223802:SUTH_RS16605
uniprot id: W0SJY4
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1223802:SUTH RS10940
gene id: 1223802:SUTH_RS10940
uniprot id: W0SGV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

1223802:SUTH RS07650
gene id: 1223802:SUTH_RS07650
uniprot id: W0SEJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1223802:SUTH RS06885
gene id: 1223802:SUTH_RS06885
uniprot id: W0SDN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1223802:SUTH RS01615
gene id: 1223802:SUTH_RS01615
uniprot id: W0SEG2
names: Cofactor
messages: Binds 1 Mg(2+) ion per subunit.

1223802:SUTH RS11700
gene id: 1223802:SUTH_RS11700
uniprot id: W0SJB8
names: Similarity
messages: Belongs to the thioredoxin family.

1223802:SUTH RS18210
gene id: 1223802:SUTH_RS18210
uniprot id: W0SBJ3
names: Similarity
messages: Belongs to the peptidase C14A family.

1223802:SUTH RS04720
gene id: 1223802:SUTH_RS04720
uniprot id: W0SC05
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS10955
gene id: 1223802:SUTH_RS10955
uniprot id: W0SJ32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

1223802:SUTH RS06845
gene id: 1223802:SUTH_RS06845
uniprot id: W0SHC0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1223802:SUTH RS02425
gene id: 1223802:SUTH_RS02425
uniprot id: W0SC48
names: Similarity
messages: Belongs to the DNase II family.

1223802:SUTH RS14185
gene id: 1223802:SUTH_RS14185
uniprot id: W0SLH0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS16055
gene id: 1223802:SUTH_RS16055
uniprot id: W0SJY0
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1223802:SUTH RS06495
gene id: 1223802:SUTH_RS06495
uniprot id: W0SD10
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS07410
gene id: 1223802:SUTH_RS07410
uniprot id: W0SDK1
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

1223802:SUTH RS14475
gene id: 1223802:SUTH_RS14475
uniprot id: W0SJ29
names: Similarity
messages: Belongs to the UPF0102 family.

1223802:SUTH RS04430
gene id: 1223802:SUTH_RS04430
uniprot id: W0SCC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

1223802:SUTH RS01610
gene id: 1223802:SUTH_RS01610
uniprot id: W0SB74
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

1223802:SUTH RS11235
gene id: 1223802:SUTH_RS11235
uniprot id: W0SJ67
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS04400
gene id: 1223802:SUTH_RS04400
uniprot id: W0SD51
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1223802:SUTH RS05755
gene id: 1223802:SUTH_RS05755
uniprot id: W0SGZ0
names: Similarity
messages: Belongs to the SCO1/2 family.

1223802:SUTH RS16540
gene id: 1223802:SUTH_RS16540
uniprot id: W0SMQ1
names: Similarity
messages: Belongs to the SCO1/2 family.

1223802:SUTH RS06515
gene id: 1223802:SUTH_RS06515
uniprot id: W0SH88
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1223802:SUTH RS05160
gene id: 1223802:SUTH_RS05160
uniprot id: W0SDK4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1223802:SUTH RS15985
gene id: 1223802:SUTH_RS15985
uniprot id: W0SJR6
names: Similarity
messages: Belongs to the malic enzymes family.
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

1223802:SUTH RS13685
gene id: 1223802:SUTH_RS13685
uniprot id: W0SL69
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1223802:SUTH RS10190
gene id: 1223802:SUTH_RS10190
uniprot id: W0SF20
names: Similarity
messages: Belongs to the peptidase A31 family.

1223802:SUTH RS10055
gene id: 1223802:SUTH_RS10055
uniprot id: W0SFX1
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

1223802:SUTH RS07400
gene id: 1223802:SUTH_RS07400
uniprot id: W0SED8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1223802:SUTH RS04435
gene id: 1223802:SUTH_RS04435
uniprot id: W0SCN8
names: Similarity
messages: Belongs to the MotB family.

1223802:SUTH RS06850
gene id: 1223802:SUTH_RS06850
uniprot id: W0SD80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1223802:SUTH RS12570
gene id: 1223802:SUTH_RS12570
uniprot id: W0SII6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

1223802:SUTH RS08590
gene id: 1223802:SUTH_RS08590
uniprot id: W0SHW3
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS13435
gene id: 1223802:SUTH_RS13435
uniprot id: W0SGR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homodimer.

1223802:SUTH RS10735
gene id: 1223802:SUTH_RS10735
uniprot id: W0SGR7
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1223802:SUTH RS04995
gene id: 1223802:SUTH_RS04995
uniprot id: W0SDH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1223802:SUTH RS11790
gene id: 1223802:SUTH_RS11790
uniprot id: W0SH97
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1223802:SUTH RS07045
gene id: 1223802:SUTH_RS07045
uniprot id: W0SHE2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1223802:SUTH RS12240
gene id: 1223802:SUTH_RS12240
uniprot id: W0SGT2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1223802:SUTH RS17230
gene id: 1223802:SUTH_RS17230
uniprot id: W0SK45
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1223802:SUTH RS00615
gene id: 1223802:SUTH_RS00615
uniprot id: W0SB25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

1223802:SUTH RS06290
gene id: 1223802:SUTH_RS06290
uniprot id: W0SDD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane
messages: Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

1223802:SUTH RS11375
gene id: 1223802:SUTH_RS11375
uniprot id: W0SGB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1223802:SUTH RS11490
gene id: 1223802:SUTH_RS11490
uniprot id: W0SJA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0114 family.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS09755
gene id: 1223802:SUTH_RS09755
uniprot id: W0SII0
names: Similarity
messages: Belongs to the HSP15 family.

1223802:SUTH RS17275
gene id: 1223802:SUTH_RS17275
uniprot id: W0SKB6
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1223802:SUTH RS01805
gene id: 1223802:SUTH_RS01805
uniprot id: W0SAC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmD/CycX/HelD family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

1223802:SUTH RS06585
gene id: 1223802:SUTH_RS06585
uniprot id: W0SDV9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1223802:SUTH RS04315
gene id: 1223802:SUTH_RS04315
uniprot id: W0SBS7
names: Similarity
messages: Belongs to the UPF0423 family.

1223802:SUTH RS17150
gene id: 1223802:SUTH_RS17150
uniprot id: W0SIB4
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.

1223802:SUTH RS05615
gene id: 1223802:SUTH_RS05615
uniprot id: W0SDT3
names: Similarity
messages: Belongs to the thioesterase PaaI family.

1223802:SUTH RS10060
gene id: 1223802:SUTH_RS10060
uniprot id: W0SIT5
names: Similarity
messages: Belongs to the hemerythrin family.

1223802:SUTH RS04615
gene id: 1223802:SUTH_RS04615
uniprot id: W0SG90
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

1223802:SUTH RS12045
gene id: 1223802:SUTH_RS12045
uniprot id: W0SHC3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1223802:SUTH RS10315
gene id: 1223802:SUTH_RS10315
uniprot id: W0SF43
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS12130
gene id: 1223802:SUTH_RS12130
uniprot id: W0SGQ8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1223802:SUTH RS01160
gene id: 1223802:SUTH_RS01160
uniprot id: W0SAY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

1223802:SUTH RS12150
gene id: 1223802:SUTH_RS12150
uniprot id: W0SHD4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

1223802:SUTH RS07380
gene id: 1223802:SUTH_RS07380
uniprot id: W0SHG4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1223802:SUTH RS00340
gene id: 1223802:SUTH_RS00340
uniprot id: W0SA85
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1223802:SUTH RS07770
gene id: 1223802:SUTH_RS07770
uniprot id: W0SHK3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1223802:SUTH RS03990
gene id: 1223802:SUTH_RS03990
uniprot id: W0SCX3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1223802:SUTH RS04310
gene id: 1223802:SUTH_RS04310
uniprot id: W0SG29
names: Similarity
messages: Belongs to the OprB family.

1223802:SUTH RS03235
gene id: 1223802:SUTH_RS03235
uniprot id: W0SCH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1223802:SUTH RS11735
gene id: 1223802:SUTH_RS11735
uniprot id: W0SH91
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS00225
gene id: 1223802:SUTH_RS00225
uniprot id: W0SDQ9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS01270
gene id: 1223802:SUTH_RS01270
uniprot id: W0SE98
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

1223802:SUTH RS08830
gene id: 1223802:SUTH_RS08830
uniprot id: W0SI00
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1223802:SUTH RS01545
gene id: 1223802:SUTH_RS01545
uniprot id: W0SA79
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS05700
gene id: 1223802:SUTH_RS05700
uniprot id: W0SDE5
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS12020
gene id: 1223802:SUTH_RS12020
uniprot id: W0SHC1
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.

1223802:SUTH RS00995
gene id: 1223802:SUTH_RS00995
uniprot id: W0SB97
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1223802:SUTH RS04985
gene id: 1223802:SUTH_RS04985
uniprot id: W0SGI9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS06605
gene id: 1223802:SUTH_RS06605
uniprot id: W0SDI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

1223802:SUTH RS15275
gene id: 1223802:SUTH_RS15275
uniprot id: W0SJJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

1223802:SUTH RS15280
gene id: 1223802:SUTH_RS15280
uniprot id: W0SIT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsQ/DivIB family. FtsQ subfamily.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

1223802:SUTH RS16790
gene id: 1223802:SUTH_RS16790
uniprot id: W0SJ95
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1223802:SUTH RS04570
gene id: 1223802:SUTH_RS04570
uniprot id: W0SBX6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

1223802:SUTH RS01670
gene id: 1223802:SUTH_RS01670
uniprot id: W0SAA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1223802:SUTH RS11200
gene id: 1223802:SUTH_RS11200
uniprot id: W0SG85
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1223802:SUTH RS08165
gene id: 1223802:SUTH_RS08165
uniprot id: W0SES3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1223802:SUTH RS03715
gene id: 1223802:SUTH_RS03715
uniprot id: W0SCA6
names: Similarity
messages: Belongs to the pirin family.

1223802:SUTH RS15295
gene id: 1223802:SUTH_RS15295
uniprot id: W0SJP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

1223802:SUTH RS01045
gene id: 1223802:SUTH_RS01045
uniprot id: W0SBA5
names: Cofactor
messages: Binds 4 [4Fe-4S] clusters per subunit.

1223802:SUTH RS13745
gene id: 1223802:SUTH_RS13745
uniprot id: W0SI11
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1223802:SUTH RS15765
gene id: 1223802:SUTH_RS15765
uniprot id: W0SJN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1223802:SUTH RS06760
gene id: 1223802:SUTH_RS06760
uniprot id: W0SDZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1223802:SUTH RS10370
gene id: 1223802:SUTH_RS10370
uniprot id: W0SGJ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1223802:SUTH RS07165
gene id: 1223802:SUTH_RS07165
uniprot id: W0SDV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrE/TusD family.
messages: Cytoplasm

1223802:SUTH RS16430
gene id: 1223802:SUTH_RS16430
uniprot id: W0SJ59
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

1223802:SUTH RS04285
gene id: 1223802:SUTH_RS04285
uniprot id: W0SG25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1223802:SUTH RS17020
gene id: 1223802:SUTH_RS17020
uniprot id: W0SMZ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

1223802:SUTH RS04370
gene id: 1223802:SUTH_RS04370
uniprot id: W0SD44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif.
messages: Membrane

1223802:SUTH RS17345
gene id: 1223802:SUTH_RS17345
uniprot id: W0SIE6
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1223802:SUTH RS10870
gene id: 1223802:SUTH_RS10870
uniprot id: W0SG22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1223802:SUTH RS02205
gene id: 1223802:SUTH_RS02205
uniprot id: W0SB70
names: PTM
messages: Binds 1 heme c group covalently per subunit.

1223802:SUTH RS12190
gene id: 1223802:SUTH_RS12190
uniprot id: W0SGZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1223802:SUTH RS05040
gene id: 1223802:SUTH_RS05040
uniprot id: W0SDI5
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

1223802:SUTH RS13590
gene id: 1223802:SUTH_RS13590
uniprot id: W0SGU3
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1223802:SUTH RS04065
gene id: 1223802:SUTH_RS04065
uniprot id: W0SCY7
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1223802:SUTH RS15555
gene id: 1223802:SUTH_RS15555
uniprot id: W0SIW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

1223802:SUTH RS11315
gene id: 1223802:SUTH_RS11315
uniprot id: W0SFM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1223802:SUTH RS15945
gene id: 1223802:SUTH_RS15945
uniprot id: W0SMF2
names: Similarity
messages: Belongs to the thioesterase PaaI family.

1223802:SUTH RS19510
gene id: 1223802:SUTH_RS19510
uniprot id: W0SB22
names: Similarity
messages: Belongs to the peptidase C14A family.
messages: Belongs to the peptidase S41A family.

1223802:SUTH RS01875
gene id: 1223802:SUTH_RS01875
uniprot id: W0SEL8
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS14720
gene id: 1223802:SUTH_RS14720
uniprot id: W0SJ72
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS03875
gene id: 1223802:SUTH_RS03875
uniprot id: W0SBJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1223802:SUTH RS12845
gene id: 1223802:SUTH_RS12845
uniprot id: W0SIL6
names: Similarity
messages: Belongs to the Ahb/Nir family.

1223802:SUTH RS02840
gene id: 1223802:SUTH_RS02840
uniprot id: W0SFB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

1223802:SUTH RS01895
gene id: 1223802:SUTH_RS01895
uniprot id: W0SBC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1223802:SUTH RS02215
gene id: 1223802:SUTH_RS02215
uniprot id: W0SEU1
names: PTM
messages: Binds 1 heme c group covalently per subunit.

1223802:SUTH RS04515
gene id: 1223802:SUTH_RS04515
uniprot id: W0SG73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

1223802:SUTH RS17245
gene id: 1223802:SUTH_RS17245
uniprot id: W0SID3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1223802:SUTH RS02700
gene id: 1223802:SUTH_RS02700
uniprot id: W0SC92
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

1223802:SUTH RS06890
gene id: 1223802:SUTH_RS06890
uniprot id: W0SE22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1223802:SUTH RS09885
gene id: 1223802:SUTH_RS09885
uniprot id: W0SEW7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1223802:SUTH RS12925
gene id: 1223802:SUTH_RS12925
uniprot id: W0SHW9
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

1223802:SUTH RS04835
gene id: 1223802:SUTH_RS04835
uniprot id: W0SCW8
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family. GreB subfamily.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.

1223802:SUTH RS00375
gene id: 1223802:SUTH_RS00375
uniprot id: W0SDU0
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1223802:SUTH RS10525
gene id: 1223802:SUTH_RS10525
uniprot id: W0SIY1
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1223802:SUTH RS08150
gene id: 1223802:SUTH_RS08150
uniprot id: W0SDZ3
names: Subunit
messages: Homodimer.

1223802:SUTH RS07145
gene id: 1223802:SUTH_RS07145
uniprot id: W0SE75
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS13910
gene id: 1223802:SUTH_RS13910
uniprot id: W0SH06
names: Similarity
messages: Belongs to the GSP E family.

1223802:SUTH RS16880
gene id: 1223802:SUTH_RS16880
uniprot id: W0SK81
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

1223802:SUTH RS14335
gene id: 1223802:SUTH_RS14335
uniprot id: W0SLJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

1223802:SUTH RS10865
gene id: 1223802:SUTH_RS10865
uniprot id: W0SGU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1223802:SUTH RS06620
gene id: 1223802:SUTH_RS06620
uniprot id: W0SD33
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1223802:SUTH RS18000
gene id: 1223802:SUTH_RS18000
uniprot id: W0SKG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

1223802:SUTH RS13425
gene id: 1223802:SUTH_RS13425
uniprot id: W0SI44
names: Similarity
messages: Belongs to the WrbA family.

1223802:SUTH RS14130
gene id: 1223802:SUTH_RS14130
uniprot id: W0SLF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1223802:SUTH RS12865
gene id: 1223802:SUTH_RS12865
uniprot id: W0SHN2
names: Cofactor
messages: Binds 1 copper ion per subunit.

1223802:SUTH RS06600
gene id: 1223802:SUTH_RS06600
uniprot id: W0SEC7
names: Similarity
messages: Belongs to the thioredoxin family.

1223802:SUTH RS01440
gene id: 1223802:SUTH_RS01440
uniprot id: W0SB39
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS13450
gene id: 1223802:SUTH_RS13450
uniprot id: W0SI47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1223802:SUTH RS15240
gene id: 1223802:SUTH_RS15240
uniprot id: W0SHI1
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

1223802:SUTH RS08300
gene id: 1223802:SUTH_RS08300
uniprot id: W0SE17
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS17240
gene id: 1223802:SUTH_RS17240
uniprot id: W0SN42
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

1223802:SUTH RS03750
gene id: 1223802:SUTH_RS03750
uniprot id: W0SBH2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1223802:SUTH RS07885
gene id: 1223802:SUTH_RS07885
uniprot id: W0SHL2
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

1223802:SUTH RS11255
gene id: 1223802:SUTH_RS11255
uniprot id: W0SGH8
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1223802:SUTH RS16170
gene id: 1223802:SUTH_RS16170
uniprot id: W0SMI8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably interacts with PlsX.

1223802:SUTH RS04595
gene id: 1223802:SUTH_RS04595
uniprot id: W0SBY1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

1223802:SUTH RS14915
gene id: 1223802:SUTH_RS14915
uniprot id: W0SHD5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1223802:SUTH RS08580
gene id: 1223802:SUTH_RS08580
uniprot id: W0SEQ7
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS12090
gene id: 1223802:SUTH_RS12090
uniprot id: W0SG12
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1223802:SUTH RS01660
gene id: 1223802:SUTH_RS01660
uniprot id: W0SB84
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1223802:SUTH RS04590
gene id: 1223802:SUTH_RS04590
uniprot id: W0SG87
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

1223802:SUTH RS07755
gene id: 1223802:SUTH_RS07755
uniprot id: W0SF32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

1223802:SUTH RS04630
gene id: 1223802:SUTH_RS04630
uniprot id: W0SCH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

1223802:SUTH RS07585
gene id: 1223802:SUTH_RS07585
uniprot id: W0SDP9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1223802:SUTH RS12015
gene id: 1223802:SUTH_RS12015
uniprot id: W0SG07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

1223802:SUTH RS00140
gene id: 1223802:SUTH_RS00140
uniprot id: W0SAU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapD family.
messages: Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
messages: Cytoplasm
messages: Interacts with FtsZ.

1223802:SUTH RS09230
gene id: 1223802:SUTH_RS09230
uniprot id: W0SEI5
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

1223802:SUTH RS13540
gene id: 1223802:SUTH_RS13540
uniprot id: W0SHY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane

1223802:SUTH RS04265
gene id: 1223802:SUTH_RS04265
uniprot id: W0SBR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1223802:SUTH RS03045
gene id: 1223802:SUTH_RS03045
uniprot id: W0SBZ2
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1223802:SUTH RS11025
gene id: 1223802:SUTH_RS11025
uniprot id: W0SGD9
names: Similarity
messages: Belongs to the UPF0111 family.

1223802:SUTH RS14345
gene id: 1223802:SUTH_RS14345
uniprot id: W0SI91
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS01745
gene id: 1223802:SUTH_RS01745
uniprot id: W0SAB4
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

1223802:SUTH RS08635
gene id: 1223802:SUTH_RS08635
uniprot id: W0SEZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZipA family.
messages: Cell inner membrane
messages: Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.

1223802:SUTH RS18405
gene id: 1223802:SUTH_RS18405
uniprot id: W0SFS3
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS06680
gene id: 1223802:SUTH_RS06680
uniprot id: W0SDJ8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS05405
gene id: 1223802:SUTH_RS05405
uniprot id: W0SCG2
names: Subcellular Location Annotation
messages: Cytoplasm

1223802:SUTH RS03340
gene id: 1223802:SUTH_RS03340
uniprot id: W0SBT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1223802:SUTH RS06860
gene id: 1223802:SUTH_RS06860
uniprot id: W0SDM8
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

1223802:SUTH RS17770
gene id: 1223802:SUTH_RS17770
uniprot id: W0SKD2
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Comprises two domains: an N-terminal domain containing the nucleotidyltransferase activity and a C-terminal HD domain associated with both phosphodiesterase and phosphatase activities.
messages: Magnesium is required for nucleotidyltransferase activity.
messages: Monomer. Can also form homodimers and oligomers.
messages: Nickel for phosphatase activity.

1223802:SUTH RS13710
gene id: 1223802:SUTH_RS13710
uniprot id: W0SL74
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1223802:SUTH RS06655
gene id: 1223802:SUTH_RS06655
uniprot id: W0SDJ4
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS05370
gene id: 1223802:SUTH_RS05370
uniprot id: W0SD88
names: Similarity
messages: Belongs to the malate synthase family.

1223802:SUTH RS13565
gene id: 1223802:SUTH_RS13565
uniprot id: W0SGT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

1223802:SUTH RS02525
gene id: 1223802:SUTH_RS02525
uniprot id: W0SC63
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1223802:SUTH RS14885
gene id: 1223802:SUTH_RS14885
uniprot id: W0SLU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1223802:SUTH RS03890
gene id: 1223802:SUTH_RS03890
uniprot id: W0SCE1
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
messages: Periplasm
messages: The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

1223802:SUTH RS08880
gene id: 1223802:SUTH_RS08880
uniprot id: W0SEC1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1223802:SUTH RS18570
gene id: 1223802:SUTH_RS18570
uniprot id: W0SHI2
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS01115
gene id: 1223802:SUTH_RS01115
uniprot id: W0SE67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ElaB/YgaM/YqjD family.
messages: Cell inner membrane
messages: Membrane

1223802:SUTH RS05735
gene id: 1223802:SUTH_RS05735
uniprot id: W0SCM3
names: Similarity
messages: Belongs to the UPF0178 family.

1223802:SUTH RS16920
gene id: 1223802:SUTH_RS16920
uniprot id: W0SMX5
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

1223802:SUTH RS06690
gene id: 1223802:SUTH_RS06690
uniprot id: W0SHA7
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1223802:SUTH RS00470
gene id: 1223802:SUTH_RS00470
uniprot id: W0SAM2
names: Similarity
messages: Belongs to the leucine-binding protein family.

1223802:SUTH RS06140
gene id: 1223802:SUTH_RS06140
uniprot id: W0SE25
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1223802:SUTH RS03765
gene id: 1223802:SUTH_RS03765
uniprot id: W0SCB6
names: Function
names: Similarity
messages: Belongs to the RuBisCO large chain family. Type II subfamily.
messages: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.

1223802:SUTH RS05445
gene id: 1223802:SUTH_RS05445
uniprot id: W0SDA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1223802:SUTH RS03580
gene id: 1223802:SUTH_RS03580
uniprot id: W0SBD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

1223802:SUTH RS14005
gene id: 1223802:SUTH_RS14005
uniprot id: W0SLD6
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1223802:SUTH RS11545
gene id: 1223802:SUTH_RS11545
uniprot id: W0SJA6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1223802:SUTH RS13145
gene id: 1223802:SUTH_RS13145
uniprot id: W0SIN6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

1223802:SUTH RS16555
gene id: 1223802:SUTH_RS16555
uniprot id: W0SJX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

1223802:SUTH RS17310
gene id: 1223802:SUTH_RS17310
uniprot id: W0SJE4
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

1223802:SUTH RS11055
gene id: 1223802:SUTH_RS11055
uniprot id: W0SJ43
names: Similarity
messages: Belongs to the BolA/IbaG family.

1223802:SUTH RS19505
gene id: 1223802:SUTH_RS19505
uniprot id: W0SA80
names: Similarity
messages: Belongs to the peptidase C14A family.

1223802:SUTH RS08060
gene id: 1223802:SUTH_RS08060
uniprot id: W0SF87
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1223802:SUTH RS10310
gene id: 1223802:SUTH_RS10310
uniprot id: W0SIW2
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS03245
gene id: 1223802:SUTH_RS03245
uniprot id: W0SC22
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1223802:SUTH RS00510
gene id: 1223802:SUTH_RS00510
uniprot id: W0S9R1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1223802:SUTH RS05275
gene id: 1223802:SUTH_RS05275
uniprot id: W0SCD4
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1223802:SUTH RS14385
gene id: 1223802:SUTH_RS14385
uniprot id: W0SLL0
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1223802:SUTH RS14060
gene id: 1223802:SUTH_RS14060
uniprot id: W0SH20
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1223802:SUTH RS11250
gene id: 1223802:SUTH_RS11250
uniprot id: W0SG91
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1223802:SUTH RS14540
gene id: 1223802:SUTH_RS14540
uniprot id: W0SH75
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

1223802:SUTH RS00285
gene id: 1223802:SUTH_RS00285
uniprot id: W0SAW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsB sub-subfamily.
messages: Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell membrane

1223802:SUTH RS00115
gene id: 1223802:SUTH_RS00115
uniprot id: W0SA51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

1223802:SUTH RS03330
gene id: 1223802:SUTH_RS03330
uniprot id: W0SB96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1223802:SUTH RS07115
gene id: 1223802:SUTH_RS07115
uniprot id: W0SDT6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

1223802:SUTH RS00540
gene id: 1223802:SUTH_RS00540
uniprot id: W0SB11
names: Function
names: Similarity
messages: Belongs to the UbiT family.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Likely functions as an accessory factor.

1223802:SUTH RS13220
gene id: 1223802:SUTH_RS13220
uniprot id: W0SIP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
messages: Cytoplasm
messages: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.

1223802:SUTH RS08465
gene id: 1223802:SUTH_RS08465
uniprot id: W0SHU1
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

1223802:SUTH RS02895
gene id: 1223802:SUTH_RS02895
uniprot id: W0SBW5
names: Function
names: Similarity
messages: Belongs to the frataxin family.
messages: Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.

1223802:SUTH RS08965
gene id: 1223802:SUTH_RS08965
uniprot id: W0SEX0
names: Similarity
messages: Belongs to the SdhE FAD assembly factor family.

1223802:SUTH RS01325
gene id: 1223802:SUTH_RS01325
uniprot id: W0SA45
names: Similarity
messages: Belongs to the GSP E family.

1223802:SUTH RS15835
gene id: 1223802:SUTH_RS15835
uniprot id: W0SJV8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS07160
gene id: 1223802:SUTH_RS07160
uniprot id: W0SEP5
names: Similarity
messages: Belongs to the DsrF/TusC family.

1223802:SUTH RS15770
gene id: 1223802:SUTH_RS15770
uniprot id: W0SIZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial glucokinase family.
messages: Cytoplasm

1223802:SUTH RS02660
gene id: 1223802:SUTH_RS02660
uniprot id: W0SF76
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1223802:SUTH RS02185
gene id: 1223802:SUTH_RS02185
uniprot id: W0SBI5
names: PTM
messages: Binds 1 heme c group covalently per subunit.

1223802:SUTH RS03810
gene id: 1223802:SUTH_RS03810
uniprot id: W0SC16
names: Similarity
messages: Belongs to the pyruvate kinase family.

1223802:SUTH RS03315
gene id: 1223802:SUTH_RS03315
uniprot id: W0SBS6
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1223802:SUTH RS16780
gene id: 1223802:SUTH_RS16780
uniprot id: W0SK69
names: Similarity
messages: Belongs to the NodU/CmcH family.

1223802:SUTH RS04845
gene id: 1223802:SUTH_RS04845
uniprot id: W0SC29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1223802:SUTH RS13165
gene id: 1223802:SUTH_RS13165
uniprot id: W0SHS0
names: Subcellular Location Annotation
messages: Cytoplasm

1223802:SUTH RS06840
gene id: 1223802:SUTH_RS06840
uniprot id: W0SE14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1223802:SUTH RS04620
gene id: 1223802:SUTH_RS04620
uniprot id: W0SBY6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Secreted

1223802:SUTH RS11385
gene id: 1223802:SUTH_RS11385
uniprot id: W0SJ93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

1223802:SUTH RS07565
gene id: 1223802:SUTH_RS07565
uniprot id: W0SF01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

1223802:SUTH RS14140
gene id: 1223802:SUTH_RS14140
uniprot id: W0SI67
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1223802:SUTH RS09300
gene id: 1223802:SUTH_RS09300
uniprot id: W0SFV9
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

1223802:SUTH RS07505
gene id: 1223802:SUTH_RS07505
uniprot id: W0SEH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS11720
gene id: 1223802:SUTH_RS11720
uniprot id: W0SGS2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1223802:SUTH RS04250
gene id: 1223802:SUTH_RS04250
uniprot id: W0SC88
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

1223802:SUTH RS15435
gene id: 1223802:SUTH_RS15435
uniprot id: W0SM74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1223802:SUTH RS14680
gene id: 1223802:SUTH_RS14680
uniprot id: W0SE97
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1223802:SUTH RS15180
gene id: 1223802:SUTH_RS15180
uniprot id: W0SIS0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1223802:SUTH RS05340
gene id: 1223802:SUTH_RS05340
uniprot id: W0SCX2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS03505
gene id: 1223802:SUTH_RS03505
uniprot id: W0SBC4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS13820
gene id: 1223802:SUTH_RS13820
uniprot id: W0SI23
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1223802:SUTH RS08250
gene id: 1223802:SUTH_RS08250
uniprot id: W0SE09
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS00845
gene id: 1223802:SUTH_RS00845
uniprot id: W0SAS7
names: Similarity
messages: Belongs to the pirin family.

1223802:SUTH RS06645
gene id: 1223802:SUTH_RS06645
uniprot id: W0SD38
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1223802:SUTH RS10620
gene id: 1223802:SUTH_RS10620
uniprot id: W0SIZ2
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1223802:SUTH RS13690
gene id: 1223802:SUTH_RS13690
uniprot id: W0SGW8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1223802:SUTH RS16535
gene id: 1223802:SUTH_RS16535
uniprot id: W0SJ71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

1223802:SUTH RS07000
gene id: 1223802:SUTH_RS07000
uniprot id: W0SDA8
names: Similarity
messages: Belongs to the Gfa family.

1223802:SUTH RS03285
gene id: 1223802:SUTH_RS03285
uniprot id: W0SCI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1223802:SUTH RS04115
gene id: 1223802:SUTH_RS04115
uniprot id: W0SCZ6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1223802:SUTH RS05165
gene id: 1223802:SUTH_RS05165
uniprot id: W0SCU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1223802:SUTH RS02540
gene id: 1223802:SUTH_RS02540
uniprot id: W0SF51
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

1223802:SUTH RS00585
gene id: 1223802:SUTH_RS00585
uniprot id: W0S9S2
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1223802:SUTH RS05290
gene id: 1223802:SUTH_RS05290
uniprot id: W0SD76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

1223802:SUTH RS06660
gene id: 1223802:SUTH_RS06660
uniprot id: W0SDX7
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1223802:SUTH RS03175
gene id: 1223802:SUTH_RS03175
uniprot id: W0SC13
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.

1223802:SUTH RS07990
gene id: 1223802:SUTH_RS07990
uniprot id: W0SF73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HscB family.
messages: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.
messages: Interacts with HscA and stimulates its ATPase activity.

1223802:SUTH RS05335
gene id: 1223802:SUTH_RS05335
uniprot id: W0SDM7
names: Similarity
messages: Belongs to the UPF0758 family.

1223802:SUTH RS13235
gene id: 1223802:SUTH_RS13235
uniprot id: W0SGM6
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS03665
gene id: 1223802:SUTH_RS03665
uniprot id: W0SBY9
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.

1223802:SUTH RS12225
gene id: 1223802:SUTH_RS12225
uniprot id: W0SJF7
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

1223802:SUTH RS16955
gene id: 1223802:SUTH_RS16955
uniprot id: W0SK84
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

1223802:SUTH RS04095
gene id: 1223802:SUTH_RS04095
uniprot id: W0SC60
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

1223802:SUTH RS15335
gene id: 1223802:SUTH_RS15335
uniprot id: W0SM56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsL family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Membrane
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

1223802:SUTH RS07945
gene id: 1223802:SUTH_RS07945
uniprot id: W0SEC9
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1223802:SUTH RS07620
gene id: 1223802:SUTH_RS07620
uniprot id: W0SE70
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS01190
gene id: 1223802:SUTH_RS01190
uniprot id: W0SE86
names: Similarity
messages: Belongs to the UPF0250 family.

1223802:SUTH RS10340
gene id: 1223802:SUTH_RS10340
uniprot id: W0SF48
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS13445
gene id: 1223802:SUTH_RS13445
uniprot id: W0SIQ5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS13775
gene id: 1223802:SUTH_RS13775
uniprot id: W0SIU7
names: Similarity
messages: Belongs to the HdrA family.

1223802:SUTH RS16850
gene id: 1223802:SUTH_RS16850
uniprot id: W0SI64
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1223802:SUTH RS01120
gene id: 1223802:SUTH_RS01120
uniprot id: W0SA05
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1223802:SUTH RS10075
gene id: 1223802:SUTH_RS10075
uniprot id: W0SFN6
names: Similarity
messages: Belongs to the peptidase A31 family.

1223802:SUTH RS18050
gene id: 1223802:SUTH_RS18050
uniprot id: W0SKH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1223802:SUTH RS16485
gene id: 1223802:SUTH_RS16485
uniprot id: W0SJ65
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1223802:SUTH RS02535
gene id: 1223802:SUTH_RS02535
uniprot id: W0SBR9
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS18020
gene id: 1223802:SUTH_RS18020
uniprot id: W0SL95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1223802:SUTH RS18630
gene id: 1223802:SUTH_RS18630
uniprot id: W0SI99
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1223802:SUTH RS06400
gene id: 1223802:SUTH_RS06400
uniprot id: W0SCZ3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS05385
gene id: 1223802:SUTH_RS05385
uniprot id: W0SDN6
names: Cofactor
messages: Can also use Mn(2+) ion.

1223802:SUTH RS01730
gene id: 1223802:SUTH_RS01730
uniprot id: W0SAY2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

1223802:SUTH RS02100
gene id: 1223802:SUTH_RS02100
uniprot id: W0SBV6
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1223802:SUTH RS03710
gene id: 1223802:SUTH_RS03710
uniprot id: W0SBZ9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1223802:SUTH RS00435
gene id: 1223802:SUTH_RS00435
uniprot id: W0SAZ5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1223802:SUTH RS03265
gene id: 1223802:SUTH_RS03265
uniprot id: W0SBR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1223802:SUTH RS00740
gene id: 1223802:SUTH_RS00740
uniprot id: W0S9U6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

1223802:SUTH RS05620
gene id: 1223802:SUTH_RS05620
uniprot id: W0SE97
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1223802:SUTH RS04540
gene id: 1223802:SUTH_RS04540
uniprot id: W0SG78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1223802:SUTH RS07510
gene id: 1223802:SUTH_RS07510
uniprot id: W0SHI7
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS10725
gene id: 1223802:SUTH_RS10725
uniprot id: W0SJ08
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1223802:SUTH RS00885
gene id: 1223802:SUTH_RS00885
uniprot id: W0SB81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1223802:SUTH RS01205
gene id: 1223802:SUTH_RS01205
uniprot id: W0SAM9
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS12915
gene id: 1223802:SUTH_RS12915
uniprot id: W0SHN7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.

1223802:SUTH RS13390
gene id: 1223802:SUTH_RS13390
uniprot id: W0SHV3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1223802:SUTH RS18035
gene id: 1223802:SUTH_RS18035
uniprot id: W0SNK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1223802:SUTH RS02465
gene id: 1223802:SUTH_RS02465
uniprot id: W0SF35
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1223802:SUTH RS08730
gene id: 1223802:SUTH_RS08730
uniprot id: W0SFK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

1223802:SUTH RS06435
gene id: 1223802:SUTH_RS06435
uniprot id: W0SDS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1223802:SUTH RS04820
gene id: 1223802:SUTH_RS04820
uniprot id: W0SC25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

1223802:SUTH RS18720
gene id: 1223802:SUTH_RS18720
uniprot id: W0SK30
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolB family.
messages: Cell outer membrane
messages: Membrane
messages: Monomer.

1223802:SUTH RS12655
gene id: 1223802:SUTH_RS12655
uniprot id: W0SKG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1223802:SUTH RS01265
gene id: 1223802:SUTH_RS01265
uniprot id: W0SB06
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

1223802:SUTH RS04655
gene id: 1223802:SUTH_RS04655
uniprot id: W0SCH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

1223802:SUTH RS03575
gene id: 1223802:SUTH_RS03575
uniprot id: W0SFN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1223802:SUTH RS06965
gene id: 1223802:SUTH_RS06965
uniprot id: W0SE38
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1223802:SUTH RS07250
gene id: 1223802:SUTH_RS07250
uniprot id: W0SE97
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1223802:SUTH RS01695
gene id: 1223802:SUTH_RS01695
uniprot id: W0SAA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

1223802:SUTH RS17535
gene id: 1223802:SUTH_RS17535
uniprot id: W0SL10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

1223802:SUTH RS11090
gene id: 1223802:SUTH_RS11090
uniprot id: W0SGY8
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS16635
gene id: 1223802:SUTH_RS16635
uniprot id: W0SJ79
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

1223802:SUTH RS09840
gene id: 1223802:SUTH_RS09840
uniprot id: W0SG79
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1223802:SUTH RS03670
gene id: 1223802:SUTH_RS03670
uniprot id: W0SFQ4
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

1223802:SUTH RS10745
gene id: 1223802:SUTH_RS10745
uniprot id: W0SG89
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.

1223802:SUTH RS06640
gene id: 1223802:SUTH_RS06640
uniprot id: W0SHA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1223802:SUTH RS02985
gene id: 1223802:SUTH_RS02985
uniprot id: W0SCD9
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS10935
gene id: 1223802:SUTH_RS10935
uniprot id: W0SFF3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1223802:SUTH RS09825
gene id: 1223802:SUTH_RS09825
uniprot id: W0SFN4
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1223802:SUTH RS16645
gene id: 1223802:SUTH_RS16645
uniprot id: W0SI37
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1223802:SUTH RS00250
gene id: 1223802:SUTH_RS00250
uniprot id: W0SDR3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

1223802:SUTH RS00315
gene id: 1223802:SUTH_RS00315
uniprot id: W0SA83
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS08760
gene id: 1223802:SUTH_RS08760
uniprot id: W0SFL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

1223802:SUTH RS03255
gene id: 1223802:SUTH_RS03255
uniprot id: W0SB83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1223802:SUTH RS11565
gene id: 1223802:SUTH_RS11565
uniprot id: W0SGN9
names: Similarity
messages: Belongs to the thioesterase PaaI family.

1223802:SUTH RS12770
gene id: 1223802:SUTH_RS12770
uniprot id: W0SIL1
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS11655
gene id: 1223802:SUTH_RS11655
uniprot id: W0SH82
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1223802:SUTH RS16750
gene id: 1223802:SUTH_RS16750
uniprot id: W0SK65
names: Similarity
messages: Belongs to the NodU/CmcH family.

1223802:SUTH RS00790
gene id: 1223802:SUTH_RS00790
uniprot id: W0SAF8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

1223802:SUTH RS11730
gene id: 1223802:SUTH_RS11730
uniprot id: W0SFU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

1223802:SUTH RS01740
gene id: 1223802:SUTH_RS01740
uniprot id: W0SEI9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1223802:SUTH RS07555
gene id: 1223802:SUTH_RS07555
uniprot id: W0SHJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family. ParE type 1 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

1223802:SUTH RS16870
gene id: 1223802:SUTH_RS16870
uniprot id: W0SMW5
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

1223802:SUTH RS15150
gene id: 1223802:SUTH_RS15150
uniprot id: W0SJI7
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

1223802:SUTH RS08955
gene id: 1223802:SUTH_RS08955
uniprot id: W0SED4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

1223802:SUTH RS18045
gene id: 1223802:SUTH_RS18045
uniprot id: W0SL99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1223802:SUTH RS05990
gene id: 1223802:SUTH_RS05990
uniprot id: W0SE03
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1223802:SUTH RS03380
gene id: 1223802:SUTH_RS03380
uniprot id: W0SBA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1223802:SUTH RS15270
gene id: 1223802:SUTH_RS15270
uniprot id: W0SJP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1223802:SUTH RS07060
gene id: 1223802:SUTH_RS07060
uniprot id: W0SDS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1223802:SUTH RS06225
gene id: 1223802:SUTH_RS06225
uniprot id: W0SDM9
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1223802:SUTH RS01310
gene id: 1223802:SUTH_RS01310
uniprot id: W0SAP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1223802:SUTH RS04660
gene id: 1223802:SUTH_RS04660
uniprot id: W0SCT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

1223802:SUTH RS01380
gene id: 1223802:SUTH_RS01380
uniprot id: W0SBG4
names: Similarity
messages: Belongs to the leucine-binding protein family.

1223802:SUTH RS05810
gene id: 1223802:SUTH_RS05810
uniprot id: W0SCN6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Monomer.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

1223802:SUTH RS01250
gene id: 1223802:SUTH_RS01250
uniprot id: W0SBD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. UvrD subfamily.
messages: Homodimer.
messages: Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.

1223802:SUTH RS03150
gene id: 1223802:SUTH_RS03150
uniprot id: W0SC09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS02470
gene id: 1223802:SUTH_RS02470
uniprot id: W0SAU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

1223802:SUTH RS05440
gene id: 1223802:SUTH_RS05440
uniprot id: W0SCY5
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1223802:SUTH RS12120
gene id: 1223802:SUTH_RS12120
uniprot id: W0SG13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

1223802:SUTH RS10575
gene id: 1223802:SUTH_RS10575
uniprot id: W0SF89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.
messages: Belongs to the SrkA/RdoA protein kinase family.
messages: Cytoplasm
messages: Monomer.

1223802:SUTH RS13945
gene id: 1223802:SUTH_RS13945
uniprot id: W0SIX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1223802:SUTH RS07735
gene id: 1223802:SUTH_RS07735
uniprot id: W0SE88
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1223802:SUTH RS17010
gene id: 1223802:SUTH_RS17010
uniprot id: W0SK22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS13035
gene id: 1223802:SUTH_RS13035
uniprot id: W0SHQ2
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

1223802:SUTH RS14735
gene id: 1223802:SUTH_RS14735
uniprot id: W0SHA2
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

1223802:SUTH RS08110
gene id: 1223802:SUTH_RS08110
uniprot id: W0SF95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1223802:SUTH RS10855
gene id: 1223802:SUTH_RS10855
uniprot id: W0SJ22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

1223802:SUTH RS12380
gene id: 1223802:SUTH_RS12380
uniprot id: W0SJG5
names: Similarity
messages: Belongs to the MoaD family.

1223802:SUTH RS05975
gene id: 1223802:SUTH_RS05975
uniprot id: W0SDI7
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1223802:SUTH RS16600
gene id: 1223802:SUTH_RS16600
uniprot id: W0SK44
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1223802:SUTH RS08510
gene id: 1223802:SUTH_RS08510
uniprot id: W0SEX3
names: Similarity
messages: Belongs to the GppA/Ppx family.

1223802:SUTH RS14175
gene id: 1223802:SUTH_RS14175
uniprot id: W0SIZ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1223802:SUTH RS11320
gene id: 1223802:SUTH_RS11320
uniprot id: W0SH33
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1223802:SUTH RS07560
gene id: 1223802:SUTH_RS07560
uniprot id: W0SDP4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

1223802:SUTH RS04980
gene id: 1223802:SUTH_RS04980
uniprot id: W0SD25
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1223802:SUTH RS17970
gene id: 1223802:SUTH_RS17970
uniprot id: W0SL84
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

1223802:SUTH RS08885
gene id: 1223802:SUTH_RS08885
uniprot id: W0SFN3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.

1223802:SUTH RS14255
gene id: 1223802:SUTH_RS14255
uniprot id: W0SIG7
names: Similarity
messages: Belongs to the GSP E family.

1223802:SUTH RS00155
gene id: 1223802:SUTH_RS00155
uniprot id: W0SDP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1223802:SUTH RS03250
gene id: 1223802:SUTH_RS03250
uniprot id: W0SFI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1223802:SUTH RS14895
gene id: 1223802:SUTH_RS14895
uniprot id: W0SIJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

1223802:SUTH RS01305
gene id: 1223802:SUTH_RS01305
uniprot id: W0SBE9
names: Similarity
messages: Belongs to the YggT family.

1223802:SUTH RS12325
gene id: 1223802:SUTH_RS12325
uniprot id: W0SH23
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS01345
gene id: 1223802:SUTH_RS01345
uniprot id: W0SEB4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1223802:SUTH RS11145
gene id: 1223802:SUTH_RS11145
uniprot id: W0SGZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1223802:SUTH RS04585
gene id: 1223802:SUTH_RS04585
uniprot id: W0SCQ9
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

1223802:SUTH RS06815
gene id: 1223802:SUTH_RS06815
uniprot id: W0SHB8
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

1223802:SUTH RS04800
gene id: 1223802:SUTH_RS04800
uniprot id: W0SDD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

1223802:SUTH RS02630
gene id: 1223802:SUTH_RS02630
uniprot id: W0SBT1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1223802:SUTH RS09800
gene id: 1223802:SUTH_RS09800
uniprot id: W0SFN0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1223802:SUTH RS18025
gene id: 1223802:SUTH_RS18025
uniprot id: W0SKH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1223802:SUTH RS15830
gene id: 1223802:SUTH_RS15830
uniprot id: W0SHR5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS02845
gene id: 1223802:SUTH_RS02845
uniprot id: W0SB10
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS08505
gene id: 1223802:SUTH_RS08505
uniprot id: W0SEP2
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

1223802:SUTH RS05400
gene id: 1223802:SUTH_RS05400
uniprot id: W0SGR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

1223802:SUTH RS15285
gene id: 1223802:SUTH_RS15285
uniprot id: W0SM50
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1223802:SUTH RS08585
gene id: 1223802:SUTH_RS08585
uniprot id: W0SEY3
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS15300
gene id: 1223802:SUTH_RS15300
uniprot id: W0SJJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

1223802:SUTH RS16435
gene id: 1223802:SUTH_RS16435
uniprot id: W0SMN3
names: Similarity
messages: Belongs to the thioredoxin family.

1223802:SUTH RS14135
gene id: 1223802:SUTH_RS14135
uniprot id: W0SH34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1223802:SUTH RS18085
gene id: 1223802:SUTH_RS18085
uniprot id: W0SNL4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS05935
gene id: 1223802:SUTH_RS05935
uniprot id: W0SCQ6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1223802:SUTH RS12050
gene id: 1223802:SUTH_RS12050
uniprot id: W0SGP1
names: Similarity
messages: Belongs to the histone deacetylase family.

1223802:SUTH RS03370
gene id: 1223802:SUTH_RS03370
uniprot id: W0SC42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1223802:SUTH RS13545
gene id: 1223802:SUTH_RS13545
uniprot id: W0SIR5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

1223802:SUTH RS00715
gene id: 1223802:SUTH_RS00715
uniprot id: W0S9U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

1223802:SUTH RS19605
gene id: 1223802:SUTH_RS19605
uniprot id: W0SDT1
names: Similarity
messages: Belongs to the hemerythrin family.

1223802:SUTH RS18695
gene id: 1223802:SUTH_RS18695
uniprot id: W0SHT8
names: Similarity
messages: Belongs to the peptidase C14A family.

1223802:SUTH RS12695
gene id: 1223802:SUTH_RS12695
uniprot id: W0SIK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1223802:SUTH RS05460
gene id: 1223802:SUTH_RS05460
uniprot id: W0SDQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1223802:SUTH RS00415
gene id: 1223802:SUTH_RS00415
uniprot id: W0SA97
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1223802:SUTH RS01585
gene id: 1223802:SUTH_RS01585
uniprot id: W0SB69
names: Similarity
messages: Belongs to the YicC/YloC family.

1223802:SUTH RS04650
gene id: 1223802:SUTH_RS04650
uniprot id: W0SDA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

1223802:SUTH RS09895
gene id: 1223802:SUTH_RS09895
uniprot id: W0SFG5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1223802:SUTH RS17960
gene id: 1223802:SUTH_RS17960
uniprot id: W0SNJ0
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

1223802:SUTH RS02155
gene id: 1223802:SUTH_RS02155
uniprot id: W0SB60
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1223802:SUTH RS14575
gene id: 1223802:SUTH_RS14575
uniprot id: W0SJ44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

1223802:SUTH RS17460
gene id: 1223802:SUTH_RS17460
uniprot id: W0SKE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

1223802:SUTH RS08725
gene id: 1223802:SUTH_RS08725
uniprot id: W0SE95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane

1223802:SUTH RS01535
gene id: 1223802:SUTH_RS01535
uniprot id: W0SB58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

1223802:SUTH RS03735
gene id: 1223802:SUTH_RS03735
uniprot id: W0SC04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1223802:SUTH RS12550
gene id: 1223802:SUTH_RS12550
uniprot id: W0SII4
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

1223802:SUTH RS18590
gene id: 1223802:SUTH_RS18590
uniprot id: W0SGH2
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS14170
gene id: 1223802:SUTH_RS14170
uniprot id: W0SI72
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1223802:SUTH RS15020
gene id: 1223802:SUTH_RS15020
uniprot id: W0SJL4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrQ family.
messages: Binds 1 FMN per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.

1223802:SUTH RS15220
gene id: 1223802:SUTH_RS15220
uniprot id: W0SJN5
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS14565
gene id: 1223802:SUTH_RS14565
uniprot id: W0SH78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1223802:SUTH RS17630
gene id: 1223802:SUTH_RS17630
uniprot id: W0SJH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS08820
gene id: 1223802:SUTH_RS08820
uniprot id: W0SEV0
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

1223802:SUTH RS08815
gene id: 1223802:SUTH_RS08815
uniprot id: W0SFM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

1223802:SUTH RS07655
gene id: 1223802:SUTH_RS07655
uniprot id: W0SHJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1223802:SUTH RS06625
gene id: 1223802:SUTH_RS06625
uniprot id: W0SED2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1223802:SUTH RS01015
gene id: 1223802:SUTH_RS01015
uniprot id: W0S9Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

1223802:SUTH RS05995
gene id: 1223802:SUTH_RS05995
uniprot id: W0SD77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1223802:SUTH RS11560
gene id: 1223802:SUTH_RS11560
uniprot id: W0SGE6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1223802:SUTH RS13370
gene id: 1223802:SUTH_RS13370
uniprot id: W0SIQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1223802:SUTH RS05600
gene id: 1223802:SUTH_RS05600
uniprot id: W0SDC8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1223802:SUTH RS01560
gene id: 1223802:SUTH_RS01560
uniprot id: W0SB64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1223802:SUTH RS07050
gene id: 1223802:SUTH_RS07050
uniprot id: W0SDB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1223802:SUTH RS09880
gene id: 1223802:SUTH_RS09880
uniprot id: W0SIK4
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

1223802:SUTH RS14165
gene id: 1223802:SUTH_RS14165
uniprot id: W0SH38
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1223802:SUTH RS14925
gene id: 1223802:SUTH_RS14925
uniprot id: W0SJ94
names: Similarity
messages: Belongs to the peptidase S11 family.

1223802:SUTH RS14145
gene id: 1223802:SUTH_RS14145
uniprot id: W0SIZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1223802:SUTH RS00130
gene id: 1223802:SUTH_RS00130
uniprot id: W0S9J8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1223802:SUTH RS03200
gene id: 1223802:SUTH_RS03200
uniprot id: W0SBR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1223802:SUTH RS02745
gene id: 1223802:SUTH_RS02745
uniprot id: W0SAZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

1223802:SUTH RS12890
gene id: 1223802:SUTH_RS12890
uniprot id: W0SHN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1223802:SUTH RS05590
gene id: 1223802:SUTH_RS05590
uniprot id: W0SDS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Belongs to the universal stress protein A family.
messages: Membrane

1223802:SUTH RS05825
gene id: 1223802:SUTH_RS05825
uniprot id: W0SDG0
names: Function
names: Subunit
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.

1223802:SUTH RS16570
gene id: 1223802:SUTH_RS16570
uniprot id: W0SI30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS00565
gene id: 1223802:SUTH_RS00565
uniprot id: W0SB16
names: Similarity
messages: Belongs to the Smg family.

1223802:SUTH RS03070
gene id: 1223802:SUTH_RS03070
uniprot id: W0SBZ7
names: Similarity
messages: Belongs to the hemerythrin family.

1223802:SUTH RS00640
gene id: 1223802:SUTH_RS00640
uniprot id: W0SB32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

1223802:SUTH RS13350
gene id: 1223802:SUTH_RS13350
uniprot id: W0SIQ0
names: Similarity
messages: Belongs to the TPP enzyme family.

1223802:SUTH RS10805
gene id: 1223802:SUTH_RS10805
uniprot id: W0SFC9
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

1223802:SUTH RS14865
gene id: 1223802:SUTH_RS14865
uniprot id: W0SHC9
names: Similarity
messages: Belongs to the peptidase S16 family.

1223802:SUTH RS00545
gene id: 1223802:SUTH_RS00545
uniprot id: W0SAB5
names: Similarity
messages: Belongs to the DEAD box helicase family.

1223802:SUTH RS16070
gene id: 1223802:SUTH_RS16070
uniprot id: W0SMH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1223802:SUTH RS09030
gene id: 1223802:SUTH_RS09030
uniprot id: W0SEE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane

1223802:SUTH RS06060
gene id: 1223802:SUTH_RS06060
uniprot id: W0SCS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

1223802:SUTH RS01975
gene id: 1223802:SUTH_RS01975
uniprot id: W0SBS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS07370
gene id: 1223802:SUTH_RS07370
uniprot id: W0SDZ5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1223802:SUTH RS15605
gene id: 1223802:SUTH_RS15605
uniprot id: W0SMA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

1223802:SUTH RS03290
gene id: 1223802:SUTH_RS03290
uniprot id: W0SBS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1223802:SUTH RS09795
gene id: 1223802:SUTH_RS09795
uniprot id: W0SFE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1223802:SUTH RS06410
gene id: 1223802:SUTH_RS06410
uniprot id: W0SDF2
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1223802:SUTH RS13260
gene id: 1223802:SUTH_RS13260
uniprot id: W0SGN1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1223802:SUTH RS08850
gene id: 1223802:SUTH_RS08850
uniprot id: W0SF28
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group II subfamily.

1223802:SUTH RS05155
gene id: 1223802:SUTH_RS05155
uniprot id: W0SCB8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1223802:SUTH RS17660
gene id: 1223802:SUTH_RS17660
uniprot id: W0SL34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1223802:SUTH RS07395
gene id: 1223802:SUTH_RS07395
uniprot id: W0SE10
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

1223802:SUTH RS05790
gene id: 1223802:SUTH_RS05790
uniprot id: W0SDW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1223802:SUTH RS14450
gene id: 1223802:SUTH_RS14450
uniprot id: W0SJ26
names: Similarity
messages: Belongs to the universal stress protein A family.

1223802:SUTH RS10535
gene id: 1223802:SUTH_RS10535
uniprot id: W0SGM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1223802:SUTH RS13510
gene id: 1223802:SUTH_RS13510
uniprot id: W0SGS9
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

1223802:SUTH RS03700
gene id: 1223802:SUTH_RS03700
uniprot id: W0SBG2
names: Function
names: Similarity
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.

1223802:SUTH RS05870
gene id: 1223802:SUTH_RS05870
uniprot id: W0SD52
names: Similarity
messages: Belongs to the long-chain O-acyltransferase family.

1223802:SUTH RS07200
gene id: 1223802:SUTH_RS07200
uniprot id: W0SE85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

1223802:SUTH RS06830
gene id: 1223802:SUTH_RS06830
uniprot id: W0SDM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

1223802:SUTH RS04280
gene id: 1223802:SUTH_RS04280
uniprot id: W0SCK7
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1223802:SUTH RS14260
gene id: 1223802:SUTH_RS14260
uniprot id: W0SLI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

1223802:SUTH RS07120
gene id: 1223802:SUTH_RS07120
uniprot id: W0SE71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1223802:SUTH RS13275
gene id: 1223802:SUTH_RS13275
uniprot id: W0SI20
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1223802:SUTH RS10920
gene id: 1223802:SUTH_RS10920
uniprot id: W0SG32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

1223802:SUTH RS16460
gene id: 1223802:SUTH_RS16460
uniprot id: W0SMN8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1223802:SUTH RS06460
gene id: 1223802:SUTH_RS06460
uniprot id: W0SDT2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS13530
gene id: 1223802:SUTH_RS13530
uniprot id: W0SL40
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1223802:SUTH RS06755
gene id: 1223802:SUTH_RS06755
uniprot id: W0SDL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Periplasm
messages: Secreted

1223802:SUTH RS03515
gene id: 1223802:SUTH_RS03515
uniprot id: W0SBW0
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

1223802:SUTH RS01035
gene id: 1223802:SUTH_RS01035
uniprot id: W0SE55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhE family.
messages: Cytoplasm
messages: Necessary for formate dehydrogenase activity.

1223802:SUTH RS07455
gene id: 1223802:SUTH_RS07455
uniprot id: W0SEF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

1223802:SUTH RS11370
gene id: 1223802:SUTH_RS11370
uniprot id: W0SH41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine.

1223802:SUTH RS15095
gene id: 1223802:SUTH_RS15095
uniprot id: W0SJM2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1223802:SUTH RS01525
gene id: 1223802:SUTH_RS01525
uniprot id: W0SBJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-2 integral membrane protein family. Lipooligosaccharide exporter (TC 3.A.1.102) subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction. Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4-linked N-acetylglucosamine oligosaccharide. This subunit encodes the transporter.
messages: The complex is composed of two ATP-binding proteins (NodI) and two transmembrane proteins (NodJ).

1223802:SUTH RS00210
gene id: 1223802:SUTH_RS00210
uniprot id: W0SAV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

1223802:SUTH RS00950
gene id: 1223802:SUTH_RS00950
uniprot id: W0SAU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

1223802:SUTH RS01375
gene id: 1223802:SUTH_RS01375
uniprot id: W0SA52
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS00265
gene id: 1223802:SUTH_RS00265
uniprot id: W0SA76
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 3 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1223802:SUTH RS12900
gene id: 1223802:SUTH_RS12900
uniprot id: W0SHW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cob(I)alamin adenosyltransferase family.
messages: Cytoplasm
messages: Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.

1223802:SUTH RS20220
gene id: 1223802:SUTH_RS20220
uniprot id: W0SEU8
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

1223802:SUTH RS05410
gene id: 1223802:SUTH_RS05410
uniprot id: W0SDP2
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1223802:SUTH RS02690
gene id: 1223802:SUTH_RS02690
uniprot id: W0SF82
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1223802:SUTH RS16360
gene id: 1223802:SUTH_RS16360
uniprot id: W0SML8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1223802:SUTH RS16595
gene id: 1223802:SUTH_RS16595
uniprot id: W0SI32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1223802:SUTH RS01795
gene id: 1223802:SUTH_RS01795
uniprot id: W0SBA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

1223802:SUTH RS09960
gene id: 1223802:SUTH_RS09960
uniprot id: W0SIS4
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1223802:SUTH RS03410
gene id: 1223802:SUTH_RS03410
uniprot id: W0SBA8
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1223802:SUTH RS03445
gene id: 1223802:SUTH_RS03445
uniprot id: W0SBU8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1223802:SUTH RS07615
gene id: 1223802:SUTH_RS07615
uniprot id: W0SF10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS03510
gene id: 1223802:SUTH_RS03510
uniprot id: W0SCM8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1223802:SUTH RS05540
gene id: 1223802:SUTH_RS05540
uniprot id: W0SDR7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

1223802:SUTH RS04830
gene id: 1223802:SUTH_RS04830
uniprot id: W0SCL5
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS10250
gene id: 1223802:SUTH_RS10250
uniprot id: W0SFR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1223802:SUTH RS05310
gene id: 1223802:SUTH_RS05310
uniprot id: W0SCW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1223802:SUTH RS12230
gene id: 1223802:SUTH_RS12230
uniprot id: W0SG26
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1223802:SUTH RS06535
gene id: 1223802:SUTH_RS06535
uniprot id: W0SDU9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1223802:SUTH RS14835
gene id: 1223802:SUTH_RS14835
uniprot id: W0SHC6
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1223802:SUTH RS05500
gene id: 1223802:SUTH_RS05500
uniprot id: W0SGT3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

1223802:SUTH RS14125
gene id: 1223802:SUTH_RS14125
uniprot id: W0SIE1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

1223802:SUTH RS12345
gene id: 1223802:SUTH_RS12345
uniprot id: W0SGW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.

1223802:SUTH RS14350
gene id: 1223802:SUTH_RS14350
uniprot id: W0SJ12
names: Similarity
messages: Belongs to the TrpC family.

1223802:SUTH RS06610
gene id: 1223802:SUTH_RS06610
uniprot id: W0SDW4
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

1223802:SUTH RS07590
gene id: 1223802:SUTH_RS07590
uniprot id: W0SF05
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1223802:SUTH RS06440
gene id: 1223802:SUTH_RS06440
uniprot id: W0SH80
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

1223802:SUTH RS19845
gene id: 1223802:SUTH_RS19845
uniprot id: W0SEF4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1223802:SUTH RS08800
gene id: 1223802:SUTH_RS08800
uniprot id: W0SF16
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1223802:SUTH RS03725
gene id: 1223802:SUTH_RS03725
uniprot id: W0SBG6
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm
messages: In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.

1223802:SUTH RS06465
gene id: 1223802:SUTH_RS06465
uniprot id: W0SH83
names: Similarity
messages: Belongs to the TrpF family.

1223802:SUTH RS18200
gene id: 1223802:SUTH_RS18200
uniprot id: W0SF30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

1223802:SUTH RS07665
gene id: 1223802:SUTH_RS07665
uniprot id: W0SF18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1223802:SUTH RS12465
gene id: 1223802:SUTH_RS12465
uniprot id: W0SG80
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1223802:SUTH RS13985
gene id: 1223802:SUTH_RS13985
uniprot id: W0SH14
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1223802:SUTH RS05135
gene id: 1223802:SUTH_RS05135
uniprot id: W0SDJ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1223802:SUTH RS13175
gene id: 1223802:SUTH_RS13175
uniprot id: W0SI06
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS12200
gene id: 1223802:SUTH_RS12200
uniprot id: W0SG21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

1223802:SUTH RS00855
gene id: 1223802:SUTH_RS00855
uniprot id: W0S9W5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1223802:SUTH RS11050
gene id: 1223802:SUTH_RS11050
uniprot id: W0SGE3
names: Similarity
messages: Belongs to the YciI family.

1223802:SUTH RS18480
gene id: 1223802:SUTH_RS18480
uniprot id: W0SFV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

1223802:SUTH RS06055
gene id: 1223802:SUTH_RS06055
uniprot id: W0SH24
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1223802:SUTH RS10985
gene id: 1223802:SUTH_RS10985
uniprot id: W0SFG4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

1223802:SUTH RS05575
gene id: 1223802:SUTH_RS05575
uniprot id: W0SDC4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1223802:SUTH RS16300
gene id: 1223802:SUTH_RS16300
uniprot id: W0SJU8
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1223802:SUTH RS07545
gene id: 1223802:SUTH_RS07545
uniprot id: W0SEZ8
names: Similarity
messages: Belongs to the threonine synthase family.

1223802:SUTH RS17050
gene id: 1223802:SUTH_RS17050
uniprot id: W0SIA7
names: Function
messages: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY.

1223802:SUTH RS04180
gene id: 1223802:SUTH_RS04180
uniprot id: W0SCJ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CcoP / FixP family.
messages: Binds 2 heme C groups per subunit.
messages: C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.
messages: Cell inner membrane
messages: Component of the cbb3-type cytochrome c oxidase.

1223802:SUTH RS15680
gene id: 1223802:SUTH_RS15680
uniprot id: W0SHP5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1223802:SUTH RS01650
gene id: 1223802:SUTH_RS01650
uniprot id: W0SBL8
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

1223802:SUTH RS13285
gene id: 1223802:SUTH_RS13285
uniprot id: W0SGN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1223802:SUTH RS01675
gene id: 1223802:SUTH_RS01675
uniprot id: W0SBM3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1223802:SUTH RS13550
gene id: 1223802:SUTH_RS13550
uniprot id: W0SI61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1223802:SUTH RS02250
gene id: 1223802:SUTH_RS02250
uniprot id: W0SBZ0
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS06405
gene id: 1223802:SUTH_RS06405
uniprot id: W0SE83
names: Similarity
messages: Belongs to the thioredoxin family.

1223802:SUTH RS09775
gene id: 1223802:SUTH_RS09775
uniprot id: W0SFM6
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1223802:SUTH RS07445
gene id: 1223802:SUTH_RS07445
uniprot id: W0SEY1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

1223802:SUTH RS14470
gene id: 1223802:SUTH_RS14470
uniprot id: W0SIB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1223802:SUTH RS03300
gene id: 1223802:SUTH_RS03300
uniprot id: W0SFI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1223802:SUTH RS10010
gene id: 1223802:SUTH_RS10010
uniprot id: W0SIT0
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1223802:SUTH RS15965
gene id: 1223802:SUTH_RS15965
uniprot id: W0SJ18
names: Subcellular Location Annotation
messages: Cytoplasm

1223802:SUTH RS01890
gene id: 1223802:SUTH_RS01890
uniprot id: W0SB07
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1223802:SUTH RS04545
gene id: 1223802:SUTH_RS04545
uniprot id: W0SBX0
names: Similarity
messages: Belongs to the MotB family.

1223802:SUTH RS04410
gene id: 1223802:SUTH_RS04410
uniprot id: W0SCN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1223802:SUTH RS05375
gene id: 1223802:SUTH_RS05375
uniprot id: W0SGR2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1223802:SUTH RS16525
gene id: 1223802:SUTH_RS16525
uniprot id: W0SK35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

1223802:SUTH RS03790
gene id: 1223802:SUTH_RS03790
uniprot id: W0SCC1
names: Similarity
messages: Belongs to the phosphoribulokinase family.

1223802:SUTH RS20205
gene id: 1223802:SUTH_RS20205
uniprot id: W0SGV2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1223802:SUTH RS05510
gene id: 1223802:SUTH_RS05510
uniprot id: W0SDR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

1223802:SUTH RS19740
gene id: 1223802:SUTH_RS19740
uniprot id: W0SJK2
names: Similarity
messages: Belongs to the universal stress protein A family.

1223802:SUTH RS08945
gene id: 1223802:SUTH_RS08945
uniprot id: W0SF50
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.
messages: The heme is bound between the two transmembrane subunits.

1223802:SUTH RS04060
gene id: 1223802:SUTH_RS04060
uniprot id: W0SBM8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS08555
gene id: 1223802:SUTH_RS08555
uniprot id: W0SEQ3
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS16450
gene id: 1223802:SUTH_RS16450
uniprot id: W0SJW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1223802:SUTH RS03035
gene id: 1223802:SUTH_RS03035
uniprot id: W0SCE9
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Member of a two-component regulatory system.

1223802:SUTH RS08915
gene id: 1223802:SUTH_RS08915
uniprot id: W0SEW5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1223802:SUTH RS12135
gene id: 1223802:SUTH_RS12135
uniprot id: W0SGY1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1223802:SUTH RS13400
gene id: 1223802:SUTH_RS13400
uniprot id: W0SI41
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

1223802:SUTH RS03350
gene id: 1223802:SUTH_RS03350
uniprot id: W0SFJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1223802:SUTH RS10755
gene id: 1223802:SUTH_RS10755
uniprot id: W0SFC1
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1223802:SUTH RS01715
gene id: 1223802:SUTH_RS01715
uniprot id: W0SEI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

1223802:SUTH RS04680
gene id: 1223802:SUTH_RS04680
uniprot id: W0SCI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliH family.
messages: Cytoplasm
messages: Needed for flagellar regrowth and assembly.

1223802:SUTH RS10070
gene id: 1223802:SUTH_RS10070
uniprot id: W0SGE5
names: Similarity
messages: Belongs to the HupF/HypC family.

1223802:SUTH RS02960
gene id: 1223802:SUTH_RS02960
uniprot id: W0SCD5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1223802:SUTH RS03940
gene id: 1223802:SUTH_RS03940
uniprot id: W0SCE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

1223802:SUTH RS04275
gene id: 1223802:SUTH_RS04275
uniprot id: W0SC93
names: Similarity
messages: Belongs to the Dps family.

1223802:SUTH RS05550
gene id: 1223802:SUTH_RS05550
uniprot id: W0SDB9
names: Function
names: Similarity
messages: Belongs to the nucleoside phosphorylase PpnP family.
messages: Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.

1223802:SUTH RS15265
gene id: 1223802:SUTH_RS15265
uniprot id: W0SHI5
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

1223802:SUTH RS15540
gene id: 1223802:SUTH_RS15540
uniprot id: W0SHM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1223802:SUTH RS13490
gene id: 1223802:SUTH_RS13490
uniprot id: W0SHX2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

1223802:SUTH RS14710
gene id: 1223802:SUTH_RS14710
uniprot id: W0SH99
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS08255
gene id: 1223802:SUTH_RS08255
uniprot id: W0SFC6
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS06820
gene id: 1223802:SUTH_RS06820
uniprot id: W0SD74
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).

1223802:SUTH RS16410
gene id: 1223802:SUTH_RS16410
uniprot id: W0SMM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Cell outer membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1223802:SUTH RS15315
gene id: 1223802:SUTH_RS15315
uniprot id: W0SHJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS12460
gene id: 1223802:SUTH_RS12460
uniprot id: W0SJI4
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1223802:SUTH RS04480
gene id: 1223802:SUTH_RS04480
uniprot id: W0SCD7
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1223802:SUTH RS07995
gene id: 1223802:SUTH_RS07995
uniprot id: W0SED7
names: Function
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.

1223802:SUTH RS03365
gene id: 1223802:SUTH_RS03365
uniprot id: W0SBT6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1223802:SUTH RS15715
gene id: 1223802:SUTH_RS15715
uniprot id: W0SJN0
names: Similarity
messages: Belongs to the RutC family.

1223802:SUTH RS16565
gene id: 1223802:SUTH_RS16565
uniprot id: W0SMQ6
names: Similarity
messages: Belongs to the SCO1/2 family.

1223802:SUTH RS14725
gene id: 1223802:SUTH_RS14725
uniprot id: W0SIM8
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS03375
gene id: 1223802:SUTH_RS03375
uniprot id: W0SFK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1223802:SUTH RS01460
gene id: 1223802:SUTH_RS01460
uniprot id: W0SAS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

1223802:SUTH RS11140
gene id: 1223802:SUTH_RS11140
uniprot id: W0SFJ0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1223802:SUTH RS06615
gene id: 1223802:SUTH_RS06615
uniprot id: W0SH98
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS05630
gene id: 1223802:SUTH_RS05630
uniprot id: W0SGW1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1223802:SUTH RS15140
gene id: 1223802:SUTH_RS15140
uniprot id: W0SHH1
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

1223802:SUTH RS01625
gene id: 1223802:SUTH_RS01625
uniprot id: W0SBL4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1223802:SUTH RS03490
gene id: 1223802:SUTH_RS03490
uniprot id: W0SBV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1223802:SUTH RS11380
gene id: 1223802:SUTH_RS11380
uniprot id: W0SGK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1223802:SUTH RS02590
gene id: 1223802:SUTH_RS02590
uniprot id: W0SAW3
names: Similarity
messages: Belongs to the P(II) protein family.

1223802:SUTH RS07730
gene id: 1223802:SUTH_RS07730
uniprot id: W0SF27
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS11020
gene id: 1223802:SUTH_RS11020
uniprot id: W0SG51
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS12930
gene id: 1223802:SUTH_RS12930
uniprot id: W0SKK8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1223802:SUTH RS13405
gene id: 1223802:SUTH_RS13405
uniprot id: W0SL16
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1223802:SUTH RS16545
gene id: 1223802:SUTH_RS16545
uniprot id: W0SI29
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

1223802:SUTH RS03805
gene id: 1223802:SUTH_RS03805
uniprot id: W0SCT8
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1223802:SUTH RS10560
gene id: 1223802:SUTH_RS10560
uniprot id: W0SFW2
names: Similarity
messages: Belongs to the AOR/FOR family.

1223802:SUTH RS08675
gene id: 1223802:SUTH_RS08675
uniprot id: W0SFJ7
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

1223802:SUTH RS06825
gene id: 1223802:SUTH_RS06825
uniprot id: W0SEG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1223802:SUTH RS17705
gene id: 1223802:SUTH_RS17705
uniprot id: W0SJH4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1223802:SUTH RS09225
gene id: 1223802:SUTH_RS09225
uniprot id: W0SIA3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

1223802:SUTH RS04560
gene id: 1223802:SUTH_RS04560
uniprot id: W0SCQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FlgA family.
messages: Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
messages: Periplasm

1223802:SUTH RS01175
gene id: 1223802:SUTH_RS01175
uniprot id: W0SBC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RlpA family.
messages: Cell membrane
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

1223802:SUTH RS07950
gene id: 1223802:SUTH_RS07950
uniprot id: W0SEN3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1223802:SUTH RS16580
gene id: 1223802:SUTH_RS16580
uniprot id: W0SJX6
names: Function
names: Similarity
messages: Belongs to the MurCDEF family. Mpl subfamily.
messages: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.

1223802:SUTH RS16910
gene id: 1223802:SUTH_RS16910
uniprot id: W0SK10
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1223802:SUTH RS08350
gene id: 1223802:SUTH_RS08350
uniprot id: W0SFE5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

1223802:SUTH RS03825
gene id: 1223802:SUTH_RS03825
uniprot id: W0SBI7
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1223802:SUTH RS04325
gene id: 1223802:SUTH_RS04325
uniprot id: W0SCA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1223802:SUTH RS01840
gene id: 1223802:SUTH_RS01840
uniprot id: W0SAZ8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

1223802:SUTH RS15360
gene id: 1223802:SUTH_RS15360
uniprot id: W0SM61
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS18060
gene id: 1223802:SUTH_RS18060
uniprot id: W0SNL0
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

1223802:SUTH RS06900
gene id: 1223802:SUTH_RS06900
uniprot id: W0SD89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

1223802:SUTH RS14765
gene id: 1223802:SUTH_RS14765
uniprot id: W0SIG8
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS10345
gene id: 1223802:SUTH_RS10345
uniprot id: W0SGJ1
names: Similarity
messages: Belongs to the TPP enzyme family.

1223802:SUTH RS12815
gene id: 1223802:SUTH_RS12815
uniprot id: W0SHM3
names: Subcellular Location Annotation
messages: Periplasm

1223802:SUTH RS05235
gene id: 1223802:SUTH_RS05235
uniprot id: W0SCV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1223802:SUTH RS14415
gene id: 1223802:SUTH_RS14415
uniprot id: W0SH59
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS13805
gene id: 1223802:SUTH_RS13805
uniprot id: W0SI87
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

1223802:SUTH RS03125
gene id: 1223802:SUTH_RS03125
uniprot id: W0SC06
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS05840
gene id: 1223802:SUTH_RS05840
uniprot id: W0SDX6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1223802:SUTH RS09255
gene id: 1223802:SUTH_RS09255
uniprot id: W0SEJ0
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

1223802:SUTH RS13410
gene id: 1223802:SUTH_RS13410
uniprot id: W0SGQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

1223802:SUTH RS17635
gene id: 1223802:SUTH_RS17635
uniprot id: W0SL28
names: Similarity
messages: Belongs to the GST superfamily.

1223802:SUTH RS16445
gene id: 1223802:SUTH_RS16445
uniprot id: W0SK18
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1223802:SUTH RS03305
gene id: 1223802:SUTH_RS03305
uniprot id: W0SB92
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1223802:SUTH RS06380
gene id: 1223802:SUTH_RS06380
uniprot id: W0SE80
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1223802:SUTH RS00450
gene id: 1223802:SUTH_RS00450
uniprot id: W0SDV1
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS07970
gene id: 1223802:SUTH_RS07970
uniprot id: W0SED3
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1223802:SUTH RS14825
gene id: 1223802:SUTH_RS14825
uniprot id: W0SIN7
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

1223802:SUTH RS07720
gene id: 1223802:SUTH_RS07720
uniprot id: W0SHK1
names: Similarity
messages: Belongs to the glutamate synthase family.

1223802:SUTH RS01990
gene id: 1223802:SUTH_RS01990
uniprot id: W0SEP4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1223802:SUTH RS11770
gene id: 1223802:SUTH_RS11770
uniprot id: W0SGI5
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1223802:SUTH RS18775
gene id: 1223802:SUTH_RS18775
uniprot id: W0SDF6
names: Similarity
messages: Belongs to the EcnA/EcnB lipoprotein family.

1223802:SUTH RS04535
gene id: 1223802:SUTH_RS04535
uniprot id: W0SCQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sigma-70 factor family. FliA subfamily.
messages: Cytoplasm
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes.

1223802:SUTH RS06210
gene id: 1223802:SUTH_RS06210
uniprot id: W0SCV7
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1223802:SUTH RS03660
gene id: 1223802:SUTH_RS03660
uniprot id: W0SCQ8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

1223802:SUTH RS11955
gene id: 1223802:SUTH_RS11955
uniprot id: W0SGU9
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS11485
gene id: 1223802:SUTH_RS11485
uniprot id: W0SGM4
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS01320
gene id: 1223802:SUTH_RS01320
uniprot id: W0SEA9
names: Similarity
messages: Belongs to the GSP E family.

1223802:SUTH RS10500
gene id: 1223802:SUTH_RS10500
uniprot id: W0SIX8
names: Similarity
messages: Belongs to the GST superfamily. HSP26 family.

1223802:SUTH RS01870
gene id: 1223802:SUTH_RS01870
uniprot id: W0SBB8
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS02625
gene id: 1223802:SUTH_RS02625
uniprot id: W0SBH1
names: Similarity
messages: Belongs to the thioesterase PaaI family.

1223802:SUTH RS10605
gene id: 1223802:SUTH_RS10605
uniprot id: W0SGP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
messages: The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).

1223802:SUTH RS03535
gene id: 1223802:SUTH_RS03535
uniprot id: W0SCN2
names: Similarity
messages: Belongs to the peptidase S41A family.

1223802:SUTH RS10140
gene id: 1223802:SUTH_RS10140
uniprot id: W0SF13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS15565
gene id: 1223802:SUTH_RS15565
uniprot id: W0SJR8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

1223802:SUTH RS14570
gene id: 1223802:SUTH_RS14570
uniprot id: W0SID1
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1223802:SUTH RS10645
gene id: 1223802:SUTH_RS10645
uniprot id: W0SIZ5
names: Similarity
messages: Belongs to the RecJ family.

1223802:SUTH RS17015
gene id: 1223802:SUTH_RS17015
uniprot id: W0SJB7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

1223802:SUTH RS01635
gene id: 1223802:SUTH_RS01635
uniprot id: W0SB79
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1223802:SUTH RS05330
gene id: 1223802:SUTH_RS05330
uniprot id: W0SCE4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1223802:SUTH RS00625
gene id: 1223802:SUTH_RS00625
uniprot id: W0SAP2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1223802:SUTH RS14770
gene id: 1223802:SUTH_RS14770
uniprot id: W0SJ77
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

1223802:SUTH RS15880
gene id: 1223802:SUTH_RS15880
uniprot id: W0SJW3
names: Similarity
messages: Belongs to the acylphosphatase family.

1223802:SUTH RS17485
gene id: 1223802:SUTH_RS17485
uniprot id: W0SKM3
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

1223802:SUTH RS03795
gene id: 1223802:SUTH_RS03795
uniprot id: W0SFS5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

1223802:SUTH RS11775
gene id: 1223802:SUTH_RS11775
uniprot id: W0SGT1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1223802:SUTH RS04110
gene id: 1223802:SUTH_RS04110
uniprot id: W0SBN6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1223802:SUTH RS01820
gene id: 1223802:SUTH_RS01820
uniprot id: W0SBB1
names: Similarity
messages: Belongs to the thioredoxin family. DsbE subfamily.

1223802:SUTH RS10885
gene id: 1223802:SUTH_RS10885
uniprot id: W0SFE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1223802:SUTH RS14930
gene id: 1223802:SUTH_RS14930
uniprot id: W0SIP6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS09845
gene id: 1223802:SUTH_RS09845
uniprot id: W0SFF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapB family.
messages: Cell inner membrane
messages: Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.

1223802:SUTH RS00930
gene id: 1223802:SUTH_RS00930
uniprot id: W0SE37
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.
messages: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
messages: Cytoplasm
messages: Homodimer.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

1223802:SUTH RS06475
gene id: 1223802:SUTH_RS06475
uniprot id: W0SEA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1223802:SUTH RS00385
gene id: 1223802:SUTH_RS00385
uniprot id: W0SAY7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS20055
gene id: 1223802:SUTH_RS20055
uniprot id: W0SEX6
names: Subcellular Location Annotation
messages: Secreted

1223802:SUTH RS13255
gene id: 1223802:SUTH_RS13255
uniprot id: W0SKP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS16415
gene id: 1223802:SUTH_RS16415
uniprot id: W0SI12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

1223802:SUTH RS12075
gene id: 1223802:SUTH_RS12075
uniprot id: W0SGP8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoS subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.

1223802:SUTH RS04775
gene id: 1223802:SUTH_RS04775
uniprot id: W0SDD0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1223802:SUTH RS00660
gene id: 1223802:SUTH_RS00660
uniprot id: W0S9T4
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS11285
gene id: 1223802:SUTH_RS11285
uniprot id: W0SJ73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1223802:SUTH RS05030
gene id: 1223802:SUTH_RS05030
uniprot id: W0SGJ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

1223802:SUTH RS04815
gene id: 1223802:SUTH_RS04815
uniprot id: W0SGC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

1223802:SUTH RS08950
gene id: 1223802:SUTH_RS08950
uniprot id: W0SI22
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.
messages: The heme is bound between the two transmembrane subunits.

1223802:SUTH RS16085
gene id: 1223802:SUTH_RS16085
uniprot id: W0SJS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1223802:SUTH RS10100
gene id: 1223802:SUTH_RS10100
uniprot id: W0SFP1
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS10970
gene id: 1223802:SUTH_RS10970
uniprot id: W0SG42
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YceF subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1223802:SUTH RS04805
gene id: 1223802:SUTH_RS04805
uniprot id: W0SCL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

1223802:SUTH RS00655
gene id: 1223802:SUTH_RS00655
uniprot id: W0SDM9
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1223802:SUTH RS04010
gene id: 1223802:SUTH_RS04010
uniprot id: W0SBM0
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1223802:SUTH RS10945
gene id: 1223802:SUTH_RS10945
uniprot id: W0SG37
names: Similarity
messages: Belongs to the fabD family.

1223802:SUTH RS06425
gene id: 1223802:SUTH_RS06425
uniprot id: W0SCZ7
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS11310
gene id: 1223802:SUTH_RS11310
uniprot id: W0SJ85
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS06880
gene id: 1223802:SUTH_RS06880
uniprot id: W0SEI1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1223802:SUTH RS17785
gene id: 1223802:SUTH_RS17785
uniprot id: W0SL54
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1223802:SUTH RS05940
gene id: 1223802:SUTH_RS05940
uniprot id: W0SDZ6
names: Similarity
messages: Belongs to the CcdB toxin family.

1223802:SUTH RS16420
gene id: 1223802:SUTH_RS16420
uniprot id: W0SK16
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS10510
gene id: 1223802:SUTH_RS10510
uniprot id: W0SGM3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

1223802:SUTH RS18535
gene id: 1223802:SUTH_RS18535
uniprot id: W0SHB4
names: Similarity
messages: Belongs to the bacterial secretin family.

1223802:SUTH RS14105
gene id: 1223802:SUTH_RS14105
uniprot id: W0SLF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1223802:SUTH RS04965
gene id: 1223802:SUTH_RS04965
uniprot id: W0SC80
names: Function
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.

1223802:SUTH RS10450
gene id: 1223802:SUTH_RS10450
uniprot id: W0SF65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

1223802:SUTH RS04610
gene id: 1223802:SUTH_RS04610
uniprot id: W0SCR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.
messages: In the C-terminal section; belongs to the glycosyl hydrolase 73 family.
messages: In the N-terminal section; belongs to the FlgJ family.
messages: Periplasm

1223802:SUTH RS08015
gene id: 1223802:SUTH_RS08015
uniprot id: W0SF78
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1223802:SUTH RS02175
gene id: 1223802:SUTH_RS02175
uniprot id: W0SBX3
names: PTM
messages: Binds 1 heme c group covalently per subunit.

1223802:SUTH RS09875
gene id: 1223802:SUTH_RS09875
uniprot id: W0SFP4
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1223802:SUTH RS08055
gene id: 1223802:SUTH_RS08055
uniprot id: W0SDX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

1223802:SUTH RS15155
gene id: 1223802:SUTH_RS15155
uniprot id: W0SIR6
names: Similarity
messages: Belongs to the peptidase U62 family.

1223802:SUTH RS17505
gene id: 1223802:SUTH_RS17505
uniprot id: W0SIJ8
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

1223802:SUTH RS08000
gene id: 1223802:SUTH_RS08000
uniprot id: W0SEP1
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

1223802:SUTH RS08215
gene id: 1223802:SUTH_RS08215
uniprot id: W0SET2
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1223802:SUTH RS05200
gene id: 1223802:SUTH_RS05200
uniprot id: W0SGM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1223802:SUTH RS03565
gene id: 1223802:SUTH_RS03565
uniprot id: W0SBX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

1223802:SUTH RS13055
gene id: 1223802:SUTH_RS13055
uniprot id: W0SGJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

1223802:SUTH RS17290
gene id: 1223802:SUTH_RS17290
uniprot id: W0SN52
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

1223802:SUTH RS03885
gene id: 1223802:SUTH_RS03885
uniprot id: W0SC28
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

1223802:SUTH RS08645
gene id: 1223802:SUTH_RS08645
uniprot id: W0SE82
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1223802:SUTH RS07390
gene id: 1223802:SUTH_RS07390
uniprot id: W0SEV2
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

1223802:SUTH RS10085
gene id: 1223802:SUTH_RS10085
uniprot id: W0SIT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1223802:SUTH RS03390
gene id: 1223802:SUTH_RS03390
uniprot id: W0SCK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1223802:SUTH RS16995
gene id: 1223802:SUTH_RS16995
uniprot id: W0SMZ0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS10770
gene id: 1223802:SUTH_RS10770
uniprot id: W0SG93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1223802:SUTH RS04330
gene id: 1223802:SUTH_RS04330
uniprot id: W0SCL9
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS02945
gene id: 1223802:SUTH_RS02945
uniprot id: W0SBX4
names: Similarity
messages: Belongs to the glutamate synthase family.

1223802:SUTH RS18180
gene id: 1223802:SUTH_RS18180
uniprot id: W0SAG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

1223802:SUTH RS04085
gene id: 1223802:SUTH_RS04085
uniprot id: W0SBN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

1223802:SUTH RS13485
gene id: 1223802:SUTH_RS13485
uniprot id: W0SGS4
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1223802:SUTH RS03230
gene id: 1223802:SUTH_RS03230
uniprot id: W0SB77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1223802:SUTH RS18080
gene id: 1223802:SUTH_RS18080
uniprot id: W0SKG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS15330
gene id: 1223802:SUTH_RS15330
uniprot id: W0SIT7
names: Function
names: Similarity
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.

1223802:SUTH RS13200
gene id: 1223802:SUTH_RS13200
uniprot id: W0SI10
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

1223802:SUTH RS16120
gene id: 1223802:SUTH_RS16120
uniprot id: W0SMI0
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS14545
gene id: 1223802:SUTH_RS14545
uniprot id: W0SIC9
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS16515
gene id: 1223802:SUTH_RS16515
uniprot id: W0SMP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

1223802:SUTH RS03590
gene id: 1223802:SUTH_RS03590
uniprot id: W0SBX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

1223802:SUTH RS11410
gene id: 1223802:SUTH_RS11410
uniprot id: W0SJ96
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

1223802:SUTH RS08515
gene id: 1223802:SUTH_RS08515
uniprot id: W0SHV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane

1223802:SUTH RS15570
gene id: 1223802:SUTH_RS15570
uniprot id: W0SJL2
names: Similarity
messages: Belongs to the PhoH family.

1223802:SUTH RS13890
gene id: 1223802:SUTH_RS13890
uniprot id: W0SH02
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS15450
gene id: 1223802:SUTH_RS15450
uniprot id: W0SJK5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS03225
gene id: 1223802:SUTH_RS03225
uniprot id: W0SFH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1223802:SUTH RS14870
gene id: 1223802:SUTH_RS14870
uniprot id: W0SII5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

1223802:SUTH RS08340
gene id: 1223802:SUTH_RS08340
uniprot id: W0SHS2
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

1223802:SUTH RS15525
gene id: 1223802:SUTH_RS15525
uniprot id: W0SJK7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 1 iron-sulfur cluster per subunit.
messages: Homodimer.
messages: Required for insertion of 4Fe-4S clusters.

1223802:SUTH RS17260
gene id: 1223802:SUTH_RS17260
uniprot id: W0SJE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1223802:SUTH RS10045
gene id: 1223802:SUTH_RS10045
uniprot id: W0SGE0
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

1223802:SUTH RS07575
gene id: 1223802:SUTH_RS07575
uniprot id: W0SEI3
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

1223802:SUTH RS15795
gene id: 1223802:SUTH_RS15795
uniprot id: W0SIZ3
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

1223802:SUTH RS08595
gene id: 1223802:SUTH_RS08595
uniprot id: W0SE72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

1223802:SUTH RS15340
gene id: 1223802:SUTH_RS15340
uniprot id: W0SHJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1223802:SUTH RS03560
gene id: 1223802:SUTH_RS03560
uniprot id: W0SCN7
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

1223802:SUTH RS14945
gene id: 1223802:SUTH_RS14945
uniprot id: W0SIJ7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1223802:SUTH RS03585
gene id: 1223802:SUTH_RS03585
uniprot id: W0SCP4
names: Similarity
messages: Belongs to the GSP E family.

1223802:SUTH RS03920
gene id: 1223802:SUTH_RS03920
uniprot id: W0SFU5
names: Function
names: Similarity
messages: Belongs to the Dus family. DusB subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1223802:SUTH RS09815
gene id: 1223802:SUTH_RS09815
uniprot id: W0SG74
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

1223802:SUTH RS03815
gene id: 1223802:SUTH_RS03815
uniprot id: W0SCC6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: One is catalytic and the other provides a structural contribution.

1223802:SUTH RS05280
gene id: 1223802:SUTH_RS05280
uniprot id: W0SDL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

1223802:SUTH RS17320
gene id: 1223802:SUTH_RS17320
uniprot id: W0SIE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1223802:SUTH RS08545
gene id: 1223802:SUTH_RS08545
uniprot id: W0SE65
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1223802:SUTH RS11150
gene id: 1223802:SUTH_RS11150
uniprot id: W0SG76
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

1223802:SUTH RS12385
gene id: 1223802:SUTH_RS12385
uniprot id: W0SG63
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1223802:SUTH RS00560
gene id: 1223802:SUTH_RS00560
uniprot id: W0S9R8
names: Similarity
messages: Belongs to the type IA topoisomerase family.

1223802:SUTH RS01640
gene id: 1223802:SUTH_RS01640
uniprot id: W0SEG7
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1223802:SUTH RS11625
gene id: 1223802:SUTH_RS11625
uniprot id: W0SFS8
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS05060
gene id: 1223802:SUTH_RS05060
uniprot id: W0SDI8
names: Similarity
messages: Belongs to the GST superfamily. NadH family.

1223802:SUTH RS00300
gene id: 1223802:SUTH_RS00300
uniprot id: W0SDS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS00645
gene id: 1223802:SUTH_RS00645
uniprot id: W0SAD0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS03325
gene id: 1223802:SUTH_RS03325
uniprot id: W0SFJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1223802:SUTH RS15825
gene id: 1223802:SUTH_RS15825
uniprot id: W0SMD3
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

1223802:SUTH RS14290
gene id: 1223802:SUTH_RS14290
uniprot id: W0SH52
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1223802:SUTH RS08805
gene id: 1223802:SUTH_RS08805
uniprot id: W0SHZ7
names: Similarity
messages: Belongs to the MEMO1 family.

1223802:SUTH RS05465
gene id: 1223802:SUTH_RS05465
uniprot id: W0SCZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1223802:SUTH RS06135
gene id: 1223802:SUTH_RS06135
uniprot id: W0SCU2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1223802:SUTH RS03690
gene id: 1223802:SUTH_RS03690
uniprot id: W0SCA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

1223802:SUTH RS01810
gene id: 1223802:SUTH_RS01810
uniprot id: W0SBP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

1223802:SUTH RS15350
gene id: 1223802:SUTH_RS15350
uniprot id: W0SJK1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

1223802:SUTH RS04770
gene id: 1223802:SUTH_RS04770
uniprot id: W0SC14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RdgC family.
messages: May be involved in recombination.
messages: nucleoid

1223802:SUTH RS09060
gene id: 1223802:SUTH_RS09060
uniprot id: W0SFR4
names: Similarity
messages: Belongs to the transposase 7 family.

1223802:SUTH RS17360
gene id: 1223802:SUTH_RS17360
uniprot id: W0SJE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

1223802:SUTH RS14995
gene id: 1223802:SUTH_RS14995
uniprot id: W0SJL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1223802:SUTH RS01835
gene id: 1223802:SUTH_RS01835
uniprot id: W0SBQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapD family.
messages: Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

1223802:SUTH RS00395
gene id: 1223802:SUTH_RS00395
uniprot id: W0SAL0
names: Similarity
messages: Belongs to the peptidase C40 family.

1223802:SUTH RS07425
gene id: 1223802:SUTH_RS07425
uniprot id: W0SEF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RlmJ family.
messages: Monomer.
messages: Specifically methylates the adenine in position 2030 of 23S rRNA.

1223802:SUTH RS15305
gene id: 1223802:SUTH_RS15305
uniprot id: W0SIT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. FtsW subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell division.

1223802:SUTH RS10860
gene id: 1223802:SUTH_RS10860
uniprot id: W0SFD9
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1223802:SUTH RS11215
gene id: 1223802:SUTH_RS11215
uniprot id: W0SFK4
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

1223802:SUTH RS01040
gene id: 1223802:SUTH_RS01040
uniprot id: W0S9Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

1223802:SUTH RS15440
gene id: 1223802:SUTH_RS15440
uniprot id: W0SHL6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1223802:SUTH RS03085
gene id: 1223802:SUTH_RS03085
uniprot id: W0SCF6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IcmF family.
messages: Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
messages: Homodimer.
messages: Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS00860
gene id: 1223802:SUTH_RS00860
uniprot id: W0SB75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1223802:SUTH RS10730
gene id: 1223802:SUTH_RS10730
uniprot id: W0SFB5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

1223802:SUTH RS06570
gene id: 1223802:SUTH_RS06570
uniprot id: W0SD23
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1223802:SUTH RS09830
gene id: 1223802:SUTH_RS09830
uniprot id: W0SIJ4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

1223802:SUTH RS16510
gene id: 1223802:SUTH_RS16510
uniprot id: W0SJ68
names: Similarity
messages: Belongs to the peptidase M16 family.

1223802:SUTH RS14465
gene id: 1223802:SUTH_RS14465
uniprot id: W0SH65
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.

1223802:SUTH RS15785
gene id: 1223802:SUTH_RS15785
uniprot id: W0SJU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

1223802:SUTH RS04525
gene id: 1223802:SUTH_RS04525
uniprot id: W0SD75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Cell membrane
messages: Membrane
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

1223802:SUTH RS04840
gene id: 1223802:SUTH_RS04840
uniprot id: W0SGD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COX15/CtaA family. Type 2 subfamily.
messages: Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
messages: Cell membrane
messages: Interacts with CtaB.
messages: Membrane

1223802:SUTH RS02230
gene id: 1223802:SUTH_RS02230
uniprot id: W0SB76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1223802:SUTH RS18585
gene id: 1223802:SUTH_RS18585
uniprot id: W0SKG2
names: Similarity
messages: Belongs to the peptidase C14A family.

1223802:SUTH RS01450
gene id: 1223802:SUTH_RS01450
uniprot id: W0SA63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1223802:SUTH RS14180
gene id: 1223802:SUTH_RS14180
uniprot id: W0SIE8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

1223802:SUTH RS13380
gene id: 1223802:SUTH_RS13380
uniprot id: W0SL12
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

1223802:SUTH RS11495
gene id: 1223802:SUTH_RS11495
uniprot id: W0SFQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

1223802:SUTH RS05490
gene id: 1223802:SUTH_RS05490
uniprot id: W0SCZ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS10170
gene id: 1223802:SUTH_RS10170
uniprot id: W0SGG0
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

1223802:SUTH RS03120
gene id: 1223802:SUTH_RS03120
uniprot id: W0SBP3
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS01480
gene id: 1223802:SUTH_RS01480
uniprot id: W0SBI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1223802:SUTH RS05515
gene id: 1223802:SUTH_RS05515
uniprot id: W0SCZ5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1223802:SUTH RS00650
gene id: 1223802:SUTH_RS00650
uniprot id: W0SAP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

1223802:SUTH RS13155
gene id: 1223802:SUTH_RS13155
uniprot id: W0SKN1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1223802:SUTH RS04025
gene id: 1223802:SUTH_RS04025
uniprot id: W0SCG1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1223802:SUTH RS01165
gene id: 1223802:SUTH_RS01165
uniprot id: W0SE81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. MrdA subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall.
messages: Cell inner membrane

1223802:SUTH RS08980
gene id: 1223802:SUTH_RS08980
uniprot id: W0SED9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

1223802:SUTH RS16470
gene id: 1223802:SUTH_RS16470
uniprot id: W0SI21
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

1223802:SUTH RS08615
gene id: 1223802:SUTH_RS08615
uniprot id: W0SHW6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1223802:SUTH RS08170
gene id: 1223802:SUTH_RS08170
uniprot id: W0SHP4
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

1223802:SUTH RS06100
gene id: 1223802:SUTH_RS06100
uniprot id: W0SDK5
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS01815
gene id: 1223802:SUTH_RS01815
uniprot id: W0SAZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

1223802:SUTH RS16185
gene id: 1223802:SUTH_RS16185
uniprot id: W0SJT6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1223802:SUTH RS05535
gene id: 1223802:SUTH_RS05535
uniprot id: W0SCI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1223802:SUTH RS01385
gene id: 1223802:SUTH_RS01385
uniprot id: W0SAQ9
names: PTM
messages: Binds 1 heme c group covalently per subunit.

1223802:SUTH RS17000
gene id: 1223802:SUTH_RS17000
uniprot id: W0SIA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 51 family.
messages: Cell inner membrane
messages: Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.

1223802:SUTH RS02825
gene id: 1223802:SUTH_RS02825
uniprot id: W0SCB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS07715
gene id: 1223802:SUTH_RS07715
uniprot id: W0SEK2
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

1223802:SUTH RS17980
gene id: 1223802:SUTH_RS17980
uniprot id: W0SKF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiJ family.
messages: Cytoplasm
messages: Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.

1223802:SUTH RS13730
gene id: 1223802:SUTH_RS13730
uniprot id: W0SI79
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

1223802:SUTH RS06500
gene id: 1223802:SUTH_RS06500
uniprot id: W0SEA6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS08710
gene id: 1223802:SUTH_RS08710
uniprot id: W0SET3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX11/CtaG family.
messages: Cell inner membrane
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.

1223802:SUTH RS18015
gene id: 1223802:SUTH_RS18015
uniprot id: W0SJK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1223802:SUTH RS19615
gene id: 1223802:SUTH_RS19615
uniprot id: W0SDF7
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

1223802:SUTH RS01315
gene id: 1223802:SUTH_RS01315
uniprot id: W0SB17
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1223802:SUTH RS16735
gene id: 1223802:SUTH_RS16735
uniprot id: W0SJ89
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1223802:SUTH RS18655
gene id: 1223802:SUTH_RS18655
uniprot id: W0SIH4
names: Similarity
messages: Belongs to the peptidase C14A family.

1223802:SUTH RS05485
gene id: 1223802:SUTH_RS05485
uniprot id: W0SDQ5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1223802:SUTH RS07090
gene id: 1223802:SUTH_RS07090
uniprot id: W0SE66
names: Similarity
messages: Belongs to the AlaDH/PNT family.

1223802:SUTH RS00145
gene id: 1223802:SUTH_RS00145
uniprot id: W0SA53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1223802:SUTH RS00305
gene id: 1223802:SUTH_RS00305
uniprot id: W0S9M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS16230
gene id: 1223802:SUTH_RS16230
uniprot id: W0SJZ4
names: Similarity
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

1223802:SUTH RS09865
gene id: 1223802:SUTH_RS09865
uniprot id: W0SG83
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1223802:SUTH RS05260
gene id: 1223802:SUTH_RS05260
uniprot id: W0SCV9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1223802:SUTH RS04670
gene id: 1223802:SUTH_RS04670
uniprot id: W0SBZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS11335
gene id: 1223802:SUTH_RS11335
uniprot id: W0SJ88
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

1223802:SUTH RS14110
gene id: 1223802:SUTH_RS14110
uniprot id: W0SH29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1223802:SUTH RS06295
gene id: 1223802:SUTH_RS06295
uniprot id: W0SDP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1223802:SUTH RS04345
gene id: 1223802:SUTH_RS04345
uniprot id: W0SD39
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1223802:SUTH RS05285
gene id: 1223802:SUTH_RS05285
uniprot id: W0SCW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1223802:SUTH RS06505
gene id: 1223802:SUTH_RS06505
uniprot id: W0SDG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
messages: Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
messages: Homotetramer.

1223802:SUTH RS08960
gene id: 1223802:SUTH_RS08960
uniprot id: W0SFP8
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

1223802:SUTH RS06990
gene id: 1223802:SUTH_RS06990
uniprot id: W0SE43
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

1223802:SUTH RS03275
gene id: 1223802:SUTH_RS03275
uniprot id: W0SFI4
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1223802:SUTH RS11715
gene id: 1223802:SUTH_RS11715
uniprot id: W0SGH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsB family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

1223802:SUTH RS17085
gene id: 1223802:SUTH_RS17085
uniprot id: W0SK28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

1223802:SUTH RS14430
gene id: 1223802:SUTH_RS14430
uniprot id: W0SIJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1223802:SUTH RS04580
gene id: 1223802:SUTH_RS04580
uniprot id: W0SCF8
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

1223802:SUTH RS14715
gene id: 1223802:SUTH_RS14715
uniprot id: W0SIG3
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS16265
gene id: 1223802:SUTH_RS16265
uniprot id: W0SJU6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS14330
gene id: 1223802:SUTH_RS14330
uniprot id: W0SIH7
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.

1223802:SUTH RS03360
gene id: 1223802:SUTH_RS03360
uniprot id: W0SCK1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1223802:SUTH RS07225
gene id: 1223802:SUTH_RS07225
uniprot id: W0SE92
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

1223802:SUTH RS10530
gene id: 1223802:SUTH_RS10530
uniprot id: W0SF79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1223802:SUTH RS01420
gene id: 1223802:SUTH_RS01420
uniprot id: W0SEC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

1223802:SUTH RS04565
gene id: 1223802:SUTH_RS04565
uniprot id: W0SG84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

1223802:SUTH RS08630
gene id: 1223802:SUTH_RS08630
uniprot id: W0SER8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1223802:SUTH RS01275
gene id: 1223802:SUTH_RS01275
uniprot id: W0SA34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1223802:SUTH RS17935
gene id: 1223802:SUTH_RS17935
uniprot id: W0SNI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1223802:SUTH RS10155
gene id: 1223802:SUTH_RS10155
uniprot id: W0SFY8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

1223802:SUTH RS06335
gene id: 1223802:SUTH_RS06335
uniprot id: W0SDQ6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1223802:SUTH RS08825
gene id: 1223802:SUTH_RS08825
uniprot id: W0SF23
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS15805
gene id: 1223802:SUTH_RS15805
uniprot id: W0SHR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1223802:SUTH RS11475
gene id: 1223802:SUTH_RS11475
uniprot id: W0SH61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1223802:SUTH RS07765
gene id: 1223802:SUTH_RS07765
uniprot id: W0SEK8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

1223802:SUTH RS18070
gene id: 1223802:SUTH_RS18070
uniprot id: W0SLA4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

1223802:SUTH RS10960
gene id: 1223802:SUTH_RS10960
uniprot id: W0SFF8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1223802:SUTH RS06870
gene id: 1223802:SUTH_RS06870
uniprot id: W0SHC2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1223802:SUTH RS01645
gene id: 1223802:SUTH_RS01645
uniprot id: W0SA95
names: Similarity
messages: Belongs to the hemerythrin family.

1223802:SUTH RS17410
gene id: 1223802:SUTH_RS17410
uniprot id: W0SN73
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS03050
gene id: 1223802:SUTH_RS03050
uniprot id: W0SFF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

1223802:SUTH RS13860
gene id: 1223802:SUTH_RS13860
uniprot id: W0SLA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1223802:SUTH RS08705
gene id: 1223802:SUTH_RS08705
uniprot id: W0SFK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

1223802:SUTH RS00355
gene id: 1223802:SUTH_RS00355
uniprot id: W0S9N5
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1223802:SUTH RS11045
gene id: 1223802:SUTH_RS11045
uniprot id: W0SG55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YciB family.
messages: Cell inner membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.

1223802:SUTH RS09750
gene id: 1223802:SUTH_RS09750
uniprot id: W0SFD0
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1223802:SUTH RS09535
gene id: 1223802:SUTH_RS09535
uniprot id: W0SIF1
names: Similarity
messages: Belongs to the peptidase S24 family.

1223802:SUTH RS11555
gene id: 1223802:SUTH_RS11555
uniprot id: W0SH70
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1223802:SUTH RS10905
gene id: 1223802:SUTH_RS10905
uniprot id: W0SJ28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RseB family.
messages: Periplasm

1223802:SUTH RS03675
gene id: 1223802:SUTH_RS03675
uniprot id: W0SBF7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

1223802:SUTH RS04270
gene id: 1223802:SUTH_RS04270
uniprot id: W0SD24
names: Function
names: Subcellular Location Annotation
messages: Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-exporting P-type ATPase A (CopA).
messages: Cytoplasm

1223802:SUTH RS15050
gene id: 1223802:SUTH_RS15050
uniprot id: W0SJH6
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.

1223802:SUTH RS15060
gene id: 1223802:SUTH_RS15060
uniprot id: W0SM09
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

1223802:SUTH RS11780
gene id: 1223802:SUTH_RS11780
uniprot id: W0SJC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the DAO family.
messages: In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family.

1223802:SUTH RS16455
gene id: 1223802:SUTH_RS16455
uniprot id: W0SJ62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1223802:SUTH RS11290
gene id: 1223802:SUTH_RS11290
uniprot id: W0SFL9
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS01150
gene id: 1223802:SUTH_RS01150
uniprot id: W0SBC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1223802:SUTH RS01155
gene id: 1223802:SUTH_RS01155
uniprot id: W0SAM0
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

1223802:SUTH RS01685
gene id: 1223802:SUTH_RS01685
uniprot id: W0SB90
names: Similarity
messages: Belongs to the barstar family.

1223802:SUTH RS03270
gene id: 1223802:SUTH_RS03270
uniprot id: W0SC26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1223802:SUTH RS06865
gene id: 1223802:SUTH_RS06865
uniprot id: W0SE18
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

1223802:SUTH RS02955
gene id: 1223802:SUTH_RS02955
uniprot id: W0SB29
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

1223802:SUTH RS01180
gene id: 1223802:SUTH_RS01180
uniprot id: W0SAM4
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

1223802:SUTH RS06090
gene id: 1223802:SUTH_RS06090
uniprot id: W0SE19
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1223802:SUTH RS10235
gene id: 1223802:SUTH_RS10235
uniprot id: W0SIV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS11110
gene id: 1223802:SUTH_RS11110
uniprot id: W0SJ48
names: Similarity
messages: Belongs to the nitroreductase family.

1223802:SUTH RS04050
gene id: 1223802:SUTH_RS04050
uniprot id: W0SCG5
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1223802:SUTH RS10930
gene id: 1223802:SUTH_RS10930
uniprot id: W0SJ31
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

1223802:SUTH RS04505
gene id: 1223802:SUTH_RS04505
uniprot id: W0SCE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheZ family.
messages: Cytoplasm

1223802:SUTH RS08985
gene id: 1223802:SUTH_RS08985
uniprot id: W0SFQ2
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1223802:SUTH RS05095
gene id: 1223802:SUTH_RS05095
uniprot id: W0SCT6
names: Similarity
messages: Belongs to the GSP E family.

1223802:SUTH RS19515
gene id: 1223802:SUTH_RS19515
uniprot id: W0S9V0
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1223802:SUTH RS04685
gene id: 1223802:SUTH_RS04685
uniprot id: W0SCT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

1223802:SUTH RS08925
gene id: 1223802:SUTH_RS08925
uniprot id: W0SI16
names: Cofactor
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.

1223802:SUTH RS13700
gene id: 1223802:SUTH_RS13700
uniprot id: W0SIT6
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

1223802:SUTH RS06485
gene id: 1223802:SUTH_RS06485
uniprot id: W0SDT7
names: Function
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.
messages: Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

1223802:SUTH RS06735
gene id: 1223802:SUTH_RS06735
uniprot id: W0SDZ2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

1223802:SUTH RS13680
gene id: 1223802:SUTH_RS13680
uniprot id: W0SI75
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1223802:SUTH RS01370
gene id: 1223802:SUTH_RS01370
uniprot id: W0SEB9
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS13535
gene id: 1223802:SUTH_RS13535
uniprot id: W0SGT4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1223802:SUTH RS12665
gene id: 1223802:SUTH_RS12665
uniprot id: W0SHK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1223802:SUTH RS14780
gene id: 1223802:SUTH_RS14780
uniprot id: W0SLT3
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS15695
gene id: 1223802:SUTH_RS15695
uniprot id: W0SIY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

1223802:SUTH RS14940
gene id: 1223802:SUTH_RS14940
uniprot id: W0SHD8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

1223802:SUTH RS08845
gene id: 1223802:SUTH_RS08845
uniprot id: W0SDM9
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1223802:SUTH RS04780
gene id: 1223802:SUTH_RS04780
uniprot id: W0SCK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility.
messages: Bacterial flagellum basal body
messages: Belongs to the YcgR family.
messages: Monomer. Interacts with the flagellar basal bodies.

1223802:SUTH RS03925
gene id: 1223802:SUTH_RS03925
uniprot id: W0SBK4
names: Similarity
messages: Belongs to the transcriptional regulatory Fis family.

1223802:SUTH RS17265
gene id: 1223802:SUTH_RS17265
uniprot id: W0SN47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

1223802:SUTH RS00295
gene id: 1223802:SUTH_RS00295
uniprot id: W0SAJ4
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1223802:SUTH RS17390
gene id: 1223802:SUTH_RS17390
uniprot id: W0SIF4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1223802:SUTH RS12685
gene id: 1223802:SUTH_RS12685
uniprot id: W0SGC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1223802:SUTH RS11645
gene id: 1223802:SUTH_RS11645
uniprot id: W0SJB4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1223802:SUTH RS05390
gene id: 1223802:SUTH_RS05390
uniprot id: W0SCX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Homotrimer.

1223802:SUTH RS05985
gene id: 1223802:SUTH_RS05985
uniprot id: W0SCR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1223802:SUTH RS12140
gene id: 1223802:SUTH_RS12140
uniprot id: W0SJE7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1223802:SUTH RS15885
gene id: 1223802:SUTH_RS15885
uniprot id: W0SJQ6
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

1223802:SUTH RS15070
gene id: 1223802:SUTH_RS15070
uniprot id: W0SJM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptA family.
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane.
messages: Periplasm

1223802:SUTH RS08840
gene id: 1223802:SUTH_RS08840
uniprot id: W0SFM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1223802:SUTH RS11960
gene id: 1223802:SUTH_RS11960
uniprot id: W0SJD6
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS15550
gene id: 1223802:SUTH_RS15550
uniprot id: W0SJK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1223802:SUTH RS08175
gene id: 1223802:SUTH_RS08175
uniprot id: W0SDZ7
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

1223802:SUTH RS00425
gene id: 1223802:SUTH_RS00425
uniprot id: W0SDU8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1223802:SUTH RS10780
gene id: 1223802:SUTH_RS10780
uniprot id: W0SFC5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1223802:SUTH RS14100
gene id: 1223802:SUTH_RS14100
uniprot id: W0SID8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1223802:SUTH RS13385
gene id: 1223802:SUTH_RS13385
uniprot id: W0SGQ4
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

1223802:SUTH RS16405
gene id: 1223802:SUTH_RS16405
uniprot id: W0SJ57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TolB family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: Periplasm
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1223802:SUTH RS07465
gene id: 1223802:SUTH_RS07465
uniprot id: W0SDM6
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

1223802:SUTH RS16290
gene id: 1223802:SUTH_RS16290
uniprot id: W0SHZ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1223802:SUTH RS01145
gene id: 1223802:SUTH_RS01145
uniprot id: W0SA10
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1223802:SUTH RS18030
gene id: 1223802:SUTH_RS18030
uniprot id: W0SKG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1223802:SUTH RS09855
gene id: 1223802:SUTH_RS09855
uniprot id: W0SIK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

1223802:SUTH RS14665
gene id: 1223802:SUTH_RS14665
uniprot id: W0SH92
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

1223802:SUTH RS02935
gene id: 1223802:SUTH_RS02935
uniprot id: W0SCD1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

1223802:SUTH RS14595
gene id: 1223802:SUTH_RS14595
uniprot id: W0SIE5
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

1223802:SUTH RS09615
gene id: 1223802:SUTH_RS09615
uniprot id: W0SES1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

1223802:SUTH RS01200
gene id: 1223802:SUTH_RS01200
uniprot id: W0SBD0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1223802:SUTH RS12730
gene id: 1223802:SUTH_RS12730
uniprot id: W0SKH3
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS18845
gene id: 1223802:SUTH_RS18845
uniprot id: W0SG36
names: Similarity
messages: Belongs to the hemerythrin family.

1223802:SUTH RS15660
gene id: 1223802:SUTH_RS15660
uniprot id: W0SJS6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiD family.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
messages: Cell membrane
messages: Homohexamer.

1223802:SUTH RS00015
gene id: 1223802:SUTH_RS00015
uniprot id: W0SDL6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1223802:SUTH RS03355
gene id: 1223802:SUTH_RS03355
uniprot id: W0SBA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1223802:SUTH RS16940
gene id: 1223802:SUTH_RS16940
uniprot id: W0SJB1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS00785
gene id: 1223802:SUTH_RS00785
uniprot id: W0SB63
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS04425
gene id: 1223802:SUTH_RS04425
uniprot id: W0SD56
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FlhC family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
messages: Heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.

1223802:SUTH RS11300
gene id: 1223802:SUTH_RS11300
uniprot id: W0SGA0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1223802:SUTH RS11875
gene id: 1223802:SUTH_RS11875
uniprot id: W0SHA6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1223802:SUTH RS15545
gene id: 1223802:SUTH_RS15545
uniprot id: W0SJR5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1223802:SUTH RS03310
gene id: 1223802:SUTH_RS03310
uniprot id: W0SCJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1223802:SUTH RS06855
gene id: 1223802:SUTH_RS06855
uniprot id: W0SEH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1223802:SUTH RS06765
gene id: 1223802:SUTH_RS06765
uniprot id: W0SHB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

1223802:SUTH RS16575
gene id: 1223802:SUTH_RS16575
uniprot id: W0SK41
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

1223802:SUTH RS07975
gene id: 1223802:SUTH_RS07975
uniprot id: W0SEN8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

1223802:SUTH RS13010
gene id: 1223802:SUTH_RS13010
uniprot id: W0SGI2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1223802:SUTH RS05395
gene id: 1223802:SUTH_RS05395
uniprot id: W0SD93
names: Function
names: Similarity
messages: Belongs to the ClpA/ClpB family.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.

1223802:SUTH RS12885
gene id: 1223802:SUTH_RS12885
uniprot id: W0SGG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1223802:SUTH RS08475
gene id: 1223802:SUTH_RS08475
uniprot id: W0SFG7
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

1223802:SUTH RS00955
gene id: 1223802:SUTH_RS00955
uniprot id: W0SE41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1223802:SUTH RS07065
gene id: 1223802:SUTH_RS07065
uniprot id: W0SE60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1223802:SUTH RS03545
gene id: 1223802:SUTH_RS03545
uniprot id: W0SC72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Homodimer.

1223802:SUTH RS00530
gene id: 1223802:SUTH_RS00530
uniprot id: W0SDW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiU subfamily.
messages: Forms an heterodimer with UbiV.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

1223802:SUTH RS02580
gene id: 1223802:SUTH_RS02580
uniprot id: W0SBS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiK family.
messages: Cytoplasm
messages: Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.

1223802:SUTH RS03320
gene id: 1223802:SUTH_RS03320
uniprot id: W0SC33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1223802:SUTH RS03425
gene id: 1223802:SUTH_RS03425
uniprot id: W0SC50
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

1223802:SUTH RS15015
gene id: 1223802:SUTH_RS15015
uniprot id: W0SHG6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the MsrP family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

1223802:SUTH RS04165
gene id: 1223802:SUTH_RS04165
uniprot id: W0SBP5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

1223802:SUTH RS07645
gene id: 1223802:SUTH_RS07645
uniprot id: W0SE76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1223802:SUTH RS06520
gene id: 1223802:SUTH_RS06520
uniprot id: W0SD14
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1223802:SUTH RS03100
gene id: 1223802:SUTH_RS03100
uniprot id: W0SC02
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

1223802:SUTH RS10850
gene id: 1223802:SUTH_RS10850
uniprot id: W0SGA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

1223802:SUTH RS08640
gene id: 1223802:SUTH_RS08640
uniprot id: W0SHX0
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS14120
gene id: 1223802:SUTH_RS14120
uniprot id: W0SIZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1223802:SUTH RS02635
gene id: 1223802:SUTH_RS02635
uniprot id: W0SF71
names: Similarity
messages: Belongs to the thioesterase PaaI family.

1223802:SUTH RS08750
gene id: 1223802:SUTH_RS08750
uniprot id: W0SHY8
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS10660
gene id: 1223802:SUTH_RS10660
uniprot id: W0SFY0
names: Similarity
messages: Belongs to the NAD synthetase family.

1223802:SUTH RS05230
gene id: 1223802:SUTH_RS05230
uniprot id: W0SDL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1223802:SUTH RS13245
gene id: 1223802:SUTH_RS13245
uniprot id: W0SIP3
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

1223802:SUTH RS04635
gene id: 1223802:SUTH_RS04635
uniprot id: W0SCS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

1223802:SUTH RS15625
gene id: 1223802:SUTH_RS15625
uniprot id: W0SE97
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1223802:SUTH RS08030
gene id: 1223802:SUTH_RS08030
uniprot id: W0SHM8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1223802:SUTH RS00975
gene id: 1223802:SUTH_RS00975
uniprot id: W0SAJ1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1223802:SUTH RS13955
gene id: 1223802:SUTH_RS13955
uniprot id: W0SLC8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS03850
gene id: 1223802:SUTH_RS03850
uniprot id: W0SBJ2
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1223802:SUTH RS02595
gene id: 1223802:SUTH_RS02595
uniprot id: W0SC74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS06545
gene id: 1223802:SUTH_RS06545
uniprot id: W0SD18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1223802:SUTH RS04485
gene id: 1223802:SUTH_RS04485
uniprot id: W0SCP3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1223802:SUTH RS15810
gene id: 1223802:SUTH_RS15810
uniprot id: W0SJU3
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

1223802:SUTH RS10400
gene id: 1223802:SUTH_RS10400
uniprot id: W0SFT6
names: Subcellular Location Annotation
messages: Cell inner membrane

1223802:SUTH RS16560
gene id: 1223802:SUTH_RS16560
uniprot id: W0SJ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

1223802:SUTH RS09785
gene id: 1223802:SUTH_RS09785
uniprot id: W0SEV1
names: Similarity
messages: Belongs to the UPF0125 (RnfH) family.

1223802:SUTH RS02610
gene id: 1223802:SUTH_RS02610
uniprot id: W0SF66
names: Subcellular Location Annotation
messages: Cytoplasm

1223802:SUTH RS08235
gene id: 1223802:SUTH_RS08235
uniprot id: W0SEI2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1223802:SUTH RS15480
gene id: 1223802:SUTH_RS15480
uniprot id: W0SIV5
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1223802:SUTH RS11195
gene id: 1223802:SUTH_RS11195
uniprot id: W0SH03
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1223802:SUTH RS08625
gene id: 1223802:SUTH_RS08625
uniprot id: W0SFI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

1223802:SUTH RS17565
gene id: 1223802:SUTH_RS17565
uniprot id: W0SKC2
names: Similarity
messages: Belongs to the asparagine synthetase family.

1223802:SUTH RS00775
gene id: 1223802:SUTH_RS00775
uniprot id: W0SAR5
names: Similarity
messages: Belongs to the CcdB toxin family.

1223802:SUTH RS09200
gene id: 1223802:SUTH_RS09200
uniprot id: W0SIA0
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1223802:SUTH RS19280
gene id: 1223802:SUTH_RS19280
uniprot id: W0SG96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

1223802:SUTH RS00820
gene id: 1223802:SUTH_RS00820
uniprot id: W0SAS4
names: Similarity
messages: Belongs to the peptidase S13 family.

1223802:SUTH RS08700
gene id: 1223802:SUTH_RS08700
uniprot id: W0SE90
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Cell membrane
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

1223802:SUTH RS06085
gene id: 1223802:SUTH_RS06085
uniprot id: W0SCT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1223802:SUTH RS11345
gene id: 1223802:SUTH_RS11345
uniprot id: W0SH37
names: Similarity
messages: Belongs to the hemerythrin family.

1223802:SUTH RS04205
gene id: 1223802:SUTH_RS04205
uniprot id: W0SCJ3
names: Similarity
messages: Belongs to the universal stress protein A family.

1223802:SUTH RS10030
gene id: 1223802:SUTH_RS10030
uniprot id: W0SFW6
names: Similarity
messages: Belongs to the HypE family.

1223802:SUTH RS00940
gene id: 1223802:SUTH_RS00940
uniprot id: W0SB89
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1223802:SUTH RS08440
gene id: 1223802:SUTH_RS08440
uniprot id: W0SE47
names: Similarity
messages: Belongs to the YjdM family.

1223802:SUTH RS00215
gene id: 1223802:SUTH_RS00215
uniprot id: W0SA68
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1223802:SUTH RS02740
gene id: 1223802:SUTH_RS02740
uniprot id: W0SF93
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

1223802:SUTH RS04420
gene id: 1223802:SUTH_RS04420
uniprot id: W0SBU6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FlhD family.
messages: Cytoplasm
messages: Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
messages: Homodimer; disulfide-linked. Forms a heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.
messages: The C-terminal region contains a putative helix-turn-helix (HTH) motif, suggesting that this region may bind DNA.

1223802:SUTH RS18520
gene id: 1223802:SUTH_RS18520
uniprot id: W0SH84
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS07530
gene id: 1223802:SUTH_RS07530
uniprot id: W0SEH6
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

1223802:SUTH RS09980
gene id: 1223802:SUTH_RS09980
uniprot id: W0SFV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

1223802:SUTH RS05240
gene id: 1223802:SUTH_RS05240
uniprot id: W0SD68
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

1223802:SUTH RS16390
gene id: 1223802:SUTH_RS16390
uniprot id: W0SI08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1223802:SUTH RS07640
gene id: 1223802:SUTH_RS07640
uniprot id: W0SF14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1223802:SUTH RS12205
gene id: 1223802:SUTH_RS12205
uniprot id: W0SHE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-transferase family. Bpt subfamily.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.

1223802:SUTH RS06015
gene id: 1223802:SUTH_RS06015
uniprot id: W0SE07
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

1223802:SUTH RS01825
gene id: 1223802:SUTH_RS01825
uniprot id: W0SEK7
names: Function
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Possible subunit of a heme lyase.

1223802:SUTH RS01710
gene id: 1223802:SUTH_RS01710
uniprot id: W0SB94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

1223802:SUTH RS15520
gene id: 1223802:SUTH_RS15520
uniprot id: W0SJR4
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

1223802:SUTH RS10205
gene id: 1223802:SUTH_RS10205
uniprot id: W0SFZ7
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

1223802:SUTH RS05325
gene id: 1223802:SUTH_RS05325
uniprot id: W0SGQ2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1223802:SUTH RS03395
gene id: 1223802:SUTH_RS03395
uniprot id: W0SBT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1223802:SUTH RS16235
gene id: 1223802:SUTH_RS16235
uniprot id: W0SJU2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1223802:SUTH RS11275
gene id: 1223802:SUTH_RS11275
uniprot id: W0SG95
names: Similarity
messages: Belongs to the skp family.

1223802:SUTH RS14935
gene id: 1223802:SUTH_RS14935
uniprot id: W0SLV3
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

1223802:SUTH RS07960
gene id: 1223802:SUTH_RS07960
uniprot id: W0SDV6
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1223802:SUTH RS11950
gene id: 1223802:SUTH_RS11950
uniprot id: W0SGM0
names: Similarity
messages: Belongs to the GSP E family.

1223802:SUTH RS06315
gene id: 1223802:SUTH_RS06315
uniprot id: W0SDD4
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS12615
gene id: 1223802:SUTH_RS12615
uniprot id: W0SHJ2
names: Similarity
messages: Belongs to the SCO1/2 family.

1223802:SUTH RS12740
gene id: 1223802:SUTH_RS12740
uniprot id: W0SHL4
names: Similarity
messages: Belongs to the SCO1/2 family.

1223802:SUTH RS17370
gene id: 1223802:SUTH_RS17370
uniprot id: W0SIF0
names: Subcellular Location Annotation
messages: Mitochondrion

1223802:SUTH RS17480
gene id: 1223802:SUTH_RS17480
uniprot id: W0SII3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

1223802:SUTH RS07955
gene id: 1223802:SUTH_RS07955
uniprot id: W0SHM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

1223802:SUTH RS15010
gene id: 1223802:SUTH_RS15010
uniprot id: W0SM00
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.

1223802:SUTH RS16155
gene id: 1223802:SUTH_RS16155
uniprot id: W0SJY5
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

1223802:SUTH RS06630
gene id: 1223802:SUTH_RS06630
uniprot id: W0SDI9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

1223802:SUTH RS10880
gene id: 1223802:SUTH_RS10880
uniprot id: W0SJ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1223802:SUTH RS15005
gene id: 1223802:SUTH_RS15005
uniprot id: W0SIQ6
names: Similarity
messages: Belongs to the fructosamine kinase family.

1223802:SUTH RS05360
gene id: 1223802:SUTH_RS05360
uniprot id: W0SDN2
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

1223802:SUTH RS13760
gene id: 1223802:SUTH_RS13760
uniprot id: W0SL86
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1223802:SUTH RS18040
gene id: 1223802:SUTH_RS18040
uniprot id: W0SJL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1223802:SUTH RS04575
gene id: 1223802:SUTH_RS04575
uniprot id: W0SD86
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

1223802:SUTH RS08285
gene id: 1223802:SUTH_RS08285
uniprot id: W0SEJ2
names: Similarity
messages: Belongs to the AOR/FOR family.

1223802:SUTH RS08345
gene id: 1223802:SUTH_RS08345
uniprot id: W0SE26
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.
messages: Methylates ribosomal protein uL3 on a specific glutamine residue.

1223802:SUTH RS15600
gene id: 1223802:SUTH_RS15600
uniprot id: W0SIW6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1223802:SUTH RS07470
gene id: 1223802:SUTH_RS07470
uniprot id: W0SEY5
names: Similarity
messages: Belongs to the PhoH family.

1223802:SUTH RS15310
gene id: 1223802:SUTH_RS15310
uniprot id: W0SM51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1223802:SUTH RS01925
gene id: 1223802:SUTH_RS01925
uniprot id: W0SEM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS17500
gene id: 1223802:SUTH_RS17500
uniprot id: W0SNA0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

1223802:SUTH RS04555
gene id: 1223802:SUTH_RS04555
uniprot id: W0SCF4
names: Function
names: Similarity
messages: Belongs to the FlgM family.
messages: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

1223802:SUTH RS12210
gene id: 1223802:SUTH_RS12210
uniprot id: W0SGS7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

1223802:SUTH RS16630
gene id: 1223802:SUTH_RS16630
uniprot id: W0SJY7
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1223802:SUTH RS10080
gene id: 1223802:SUTH_RS10080
uniprot id: W0SFX5
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1223802:SUTH RS03935
gene id: 1223802:SUTH_RS03935
uniprot id: W0SC37
names: Similarity
messages: Belongs to the GARS family.

1223802:SUTH RS07500
gene id: 1223802:SUTH_RS07500
uniprot id: W0SE44
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1223802:SUTH RS10515
gene id: 1223802:SUTH_RS10515
uniprot id: W0SFV2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

1223802:SUTH RS14615
gene id: 1223802:SUTH_RS14615
uniprot id: W0SH85
names: Similarity
messages: Belongs to the hyi family.

1223802:SUTH RS16930
gene id: 1223802:SUTH_RS16930
uniprot id: W0SK83
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1223802:SUTH RS15760
gene id: 1223802:SUTH_RS15760
uniprot id: W0SJT8
names: Similarity
messages: Belongs to the peptidase M17 family.

1223802:SUTH RS06575
gene id: 1223802:SUTH_RS06575
uniprot id: W0SEC2
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1223802:SUTH RS05685
gene id: 1223802:SUTH_RS05685
uniprot id: W0SCL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

1223802:SUTH RS05650
gene id: 1223802:SUTH_RS05650
uniprot id: W0SDD5
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS08715
gene id: 1223802:SUTH_RS08715
uniprot id: W0SF04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS10175
gene id: 1223802:SUTH_RS10175
uniprot id: W0SFQ3
names: Similarity
messages: Belongs to the complex I 75 kDa subunit family.

1223802:SUTH RS13975
gene id: 1223802:SUTH_RS13975
uniprot id: W0SIB7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1223802:SUTH RS09545
gene id: 1223802:SUTH_RS09545
uniprot id: W0SG17
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

1223802:SUTH RS11210
gene id: 1223802:SUTH_RS11210
uniprot id: W0SJ64
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS00330
gene id: 1223802:SUTH_RS00330
uniprot id: W0S9N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1223802:SUTH RS15575
gene id: 1223802:SUTH_RS15575
uniprot id: W0SIW3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1223802:SUTH RS08480
gene id: 1223802:SUTH_RS08480
uniprot id: W0SEN6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase E/G family. RNase E subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per homotetramer.
messages: Cell inner membrane
messages: Cytoplasm
messages: Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.
messages: Homotetramer formed by a dimer of dimers.

1223802:SUTH RS09710
gene id: 1223802:SUTH_RS09710
uniprot id: W0SFL0
names: Similarity
messages: Belongs to the ParB family.

1223802:SUTH RS12125
gene id: 1223802:SUTH_RS12125
uniprot id: W0SHD1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1223802:SUTH RS09740
gene id: 1223802:SUTH_RS09740
uniprot id: W0SEU3
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS17995
gene id: 1223802:SUTH_RS17995
uniprot id: W0SL89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

1223802:SUTH RS10040
gene id: 1223802:SUTH_RS10040
uniprot id: W0SEZ7
names: Similarity
messages: Belongs to the HupF/HypC family.

1223802:SUTH RS07800
gene id: 1223802:SUTH_RS07800
uniprot id: W0SDT0
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.

1223802:SUTH RS01135
gene id: 1223802:SUTH_RS01135
uniprot id: W0SAX9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1223802:SUTH RS00945
gene id: 1223802:SUTH_RS00945
uniprot id: W0SAI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1223802:SUTH RS13080
gene id: 1223802:SUTH_RS13080
uniprot id: W0SE97
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

1223802:SUTH RS12540
gene id: 1223802:SUTH_RS12540
uniprot id: W0SG99
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1223802:SUTH RS09630
gene id: 1223802:SUTH_RS09630
uniprot id: W0SFJ2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1223802:SUTH RS00800
gene id: 1223802:SUTH_RS00800
uniprot id: W0SE16
names: Similarity
messages: Belongs to the glutathione peroxidase family.

1223802:SUTH RS03295
gene id: 1223802:SUTH_RS03295
uniprot id: W0SC30
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1223802:SUTH RS03280
gene id: 1223802:SUTH_RS03280
uniprot id: W0SB87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1223802:SUTH RS11550
gene id: 1223802:SUTH_RS11550
uniprot id: W0SFR6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1223802:SUTH RS17740
gene id: 1223802:SUTH_RS17740
uniprot id: W0SKD9
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

1223802:SUTH RS15815
gene id: 1223802:SUTH_RS15815
uniprot id: W0SJP3
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

1223802:SUTH RS14190
gene id: 1223802:SUTH_RS14190
uniprot id: W0SH42
names: Similarity
messages: Belongs to the BolA/IbaG family.

1223802:SUTH RS03800
gene id: 1223802:SUTH_RS03800
uniprot id: W0SBI2
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1223802:SUTH RS10580
gene id: 1223802:SUTH_RS10580
uniprot id: W0SGN7
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS04475
gene id: 1223802:SUTH_RS04475
uniprot id: W0SD65
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

1223802:SUTH RS11520
gene id: 1223802:SUTH_RS11520
uniprot id: W0SJA4
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1223802:SUTH RS10350
gene id: 1223802:SUTH_RS10350
uniprot id: W0SFT0
names: Similarity
messages: Belongs to the TPP enzyme family.

1223802:SUTH RS01960
gene id: 1223802:SUTH_RS01960
uniprot id: W0SBS5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1223802:SUTH RS08970
gene id: 1223802:SUTH_RS08970
uniprot id: W0SF54
names: Similarity
messages: Belongs to the citrate synthase family.

1223802:SUTH RS09265
gene id: 1223802:SUTH_RS09265
uniprot id: W0SF17
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1223802:SUTH RS12835
gene id: 1223802:SUTH_RS12835
uniprot id: W0SGF1
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

1223802:SUTH RS06480
gene id: 1223802:SUTH_RS06480
uniprot id: W0SDG3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1223802:SUTH RS10110
gene id: 1223802:SUTH_RS10110
uniprot id: W0SIU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

1223802:SUTH RS10765
gene id: 1223802:SUTH_RS10765
uniprot id: W0SFZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1223802:SUTH RS01860
gene id: 1223802:SUTH_RS01860
uniprot id: W0SBQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapF family.
messages: Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

1223802:SUTH RS08025
gene id: 1223802:SUTH_RS08025
uniprot id: W0SEP6
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

1223802:SUTH RS00235
gene id: 1223802:SUTH_RS00235
uniprot id: W0SAV7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.

1223802:SUTH RS00390
gene id: 1223802:SUTH_RS00390
uniprot id: W0SA94
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1223802:SUTH RS06415
gene id: 1223802:SUTH_RS06415
uniprot id: W0SDS3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

1223802:SUTH RS02225
gene id: 1223802:SUTH_RS02225
uniprot id: W0SBY4
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1223802:SUTH RS02925
gene id: 1223802:SUTH_RS02925
uniprot id: W0SFC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial secretin family. PilQ subfamily.
messages: Cell outer membrane
messages: Homododecamer. Tetramer of trimer.
messages: Required for type IV pilus biogenesis and competence. Could function as a pore for exit of the pilus but also as a channel for entry of heme and antimicrobial agents and uptake of transforming DNA.

1223802:SUTH RS00255
gene id: 1223802:SUTH_RS00255
uniprot id: W0S9L9
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS08100
gene id: 1223802:SUTH_RS08100
uniprot id: W0SHN5
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

1223802:SUTH RS05145
gene id: 1223802:SUTH_RS05145
uniprot id: W0SD55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1223802:SUTH RS13330
gene id: 1223802:SUTH_RS13330
uniprot id: W0SI26
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1223802:SUTH RS15630
gene id: 1223802:SUTH_RS15630
uniprot id: W0SMA4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 nickel ion per subunit.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

1223802:SUTH RS03820
gene id: 1223802:SUTH_RS03820
uniprot id: W0SFS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PsiE family.
messages: Cell inner membrane
messages: Membrane

1223802:SUTH RS04450
gene id: 1223802:SUTH_RS04450
uniprot id: W0SD59
names: Function
messages: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY.

1223802:SUTH RS10610
gene id: 1223802:SUTH_RS10610
uniprot id: W0SFX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1223802:SUTH RS01680
gene id: 1223802:SUTH_RS01680
uniprot id: W0SAX1
names: Cofactor
messages: Binds 1 Mg(2+) ion per subunit.

1223802:SUTH RS10185
gene id: 1223802:SUTH_RS10185
uniprot id: W0SIU8
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1223802:SUTH RS16965
gene id: 1223802:SUTH_RS16965
uniprot id: W0SJB3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1223802:SUTH RS15780
gene id: 1223802:SUTH_RS15780
uniprot id: W0SHQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

1223802:SUTH RS14215
gene id: 1223802:SUTH_RS14215
uniprot id: W0SH45
names: Similarity
messages: Belongs to the MlaA family.

1223802:SUTH RS17710
gene id: 1223802:SUTH_RS17710
uniprot id: W0SL42
names: Subcellular Location Annotation
messages: Membrane

1223802:SUTH RS19285
gene id: 1223802:SUTH_RS19285
uniprot id: W0SBZ1
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliO/MopB family.
messages: Cell membrane

1223802:SUTH RS14010
gene id: 1223802:SUTH_RS14010
uniprot id: W0SH16
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

1223802:SUTH RS10035
gene id: 1223802:SUTH_RS10035
uniprot id: W0SIT3
names: Similarity
messages: Belongs to the HypD family.

1223802:SUTH RS08115
gene id: 1223802:SUTH_RS08115
uniprot id: W0SEF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1223802:SUTH RS03945
gene id: 1223802:SUTH_RS03945
uniprot id: W0SFU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

1223802:SUTH RS06385
gene id: 1223802:SUTH_RS06385
uniprot id: W0SDE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

1223802:SUTH RS13605
gene id: 1223802:SUTH_RS13605
uniprot id: W0SI68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1223802:SUTH RS11330
gene id: 1223802:SUTH_RS11330
uniprot id: W0SGJ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1223802:SUTH RS07150
gene id: 1223802:SUTH_RS07150
uniprot id: W0SHE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

1223802:SUTH RS05305
gene id: 1223802:SUTH_RS05305
uniprot id: W0SDM0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

1223802:SUTH RS15510
gene id: 1223802:SUTH_RS15510
uniprot id: W0SM82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1223802:SUTH RS14900
gene id: 1223802:SUTH_RS14900
uniprot id: W0SJ90
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Involved in a late step of protoheme IX synthesis.
messages: Membrane

1223802:SUTH RS02105
gene id: 1223802:SUTH_RS02105
uniprot id: W0SB50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1223802:SUTH RS03930
gene id: 1223802:SUTH_RS03930
uniprot id: W0SCW4
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1223802:SUTH RS04385
gene id: 1223802:SUTH_RS04385
uniprot id: W0SG46
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS15850
gene id: 1223802:SUTH_RS15850
uniprot id: W0SMD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

1223802:SUTH RS03345
gene id: 1223802:SUTH_RS03345
uniprot id: W0SC38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1223802:SUTH RS03010
gene id: 1223802:SUTH_RS03010
uniprot id: W0SCE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

1223802:SUTH RS09790
gene id: 1223802:SUTH_RS09790
uniprot id: W0SG68
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

1223802:SUTH RS05850
gene id: 1223802:SUTH_RS05850
uniprot id: W0SDG5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1223802:SUTH RS11305
gene id: 1223802:SUTH_RS11305
uniprot id: W0SGI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1223802:SUTH RS20190
gene id: 1223802:SUTH_RS20190
uniprot id: W0SCD0
names: Function
names: Subunit
messages: Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second-messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a possible effector protein.
messages: Monomer in both c-di-GMP-bound and free forms.

1223802:SUTH RS03240
gene id: 1223802:SUTH_RS03240
uniprot id: W0SBR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1223802:SUTH RS11590
gene id: 1223802:SUTH_RS11590
uniprot id: W0SGP5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1223802:SUTH RS11795
gene id: 1223802:SUTH_RS11795
uniprot id: W0SGJ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1223802:SUTH RS05345
gene id: 1223802:SUTH_RS05345
uniprot id: W0SD83
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

1223802:SUTH RS11765
gene id: 1223802:SUTH_RS11765
uniprot id: W0SH94
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1223802:SUTH RS03785
gene id: 1223802:SUTH_RS03785
uniprot id: W0SC12
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1223802:SUTH RS13950
gene id: 1223802:SUTH_RS13950
uniprot id: W0SIB3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1223802:SUTH RS17455
gene id: 1223802:SUTH_RS17455
uniprot id: W0SIH8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.