1198449:ACAM RS06895
gene id: 1198449:ACAM_RS06895
uniprot id: U3TFL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1198449:ACAM RS00300
gene id: 1198449:ACAM_RS00300
uniprot id: U3TDU1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
messages: Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity.

1198449:ACAM RS01670
gene id: 1198449:ACAM_RS01670
uniprot id: U3T8E2
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

1198449:ACAM RS07455
gene id: 1198449:ACAM_RS07455
uniprot id: U3THV7
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

1198449:ACAM RS08175
gene id: 1198449:ACAM_RS08175
uniprot id: U3TF43
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS01625
gene id: 1198449:ACAM_RS01625
uniprot id: U3TCU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

1198449:ACAM RS04515
gene id: 1198449:ACAM_RS04515
uniprot id: U3TEH4
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS05900
gene id: 1198449:ACAM_RS05900
uniprot id: U3TF44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1198449:ACAM RS05875
gene id: 1198449:ACAM_RS05875
uniprot id: U3TF40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

1198449:ACAM RS06405
gene id: 1198449:ACAM_RS06405
uniprot id: U3TFH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1198449:ACAM RS04445
gene id: 1198449:ACAM_RS04445
uniprot id: U3TG96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1198449:ACAM RS05950
gene id: 1198449:ACAM_RS05950
uniprot id: U3TF99
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1198449:ACAM RS06920
gene id: 1198449:ACAM_RS06920
uniprot id: U3TFL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

1198449:ACAM RS04500
gene id: 1198449:ACAM_RS04500
uniprot id: U3TE94
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS08295
gene id: 1198449:ACAM_RS08295
uniprot id: U3TIE5
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

1198449:ACAM RS07900
gene id: 1198449:ACAM_RS07900
uniprot id: U3TBW2
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1198449:ACAM RS01325
gene id: 1198449:ACAM_RS01325
uniprot id: U3TBD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1198449:ACAM RS02895
gene id: 1198449:ACAM_RS02895
uniprot id: U3T934
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS04415
gene id: 1198449:ACAM_RS04415
uniprot id: U3TEF4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1198449:ACAM RS05230
gene id: 1198449:ACAM_RS05230
uniprot id: U3TAE3
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1198449:ACAM RS03580
gene id: 1198449:ACAM_RS03580
uniprot id: U3TFT7
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

1198449:ACAM RS05270
gene id: 1198449:ACAM_RS05270
uniprot id: U3TEQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1198449:ACAM RS04620
gene id: 1198449:ACAM_RS04620
uniprot id: U3TGC7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

1198449:ACAM RS08020
gene id: 1198449:ACAM_RS08020
uniprot id: U3TBY6
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS01990
gene id: 1198449:ACAM_RS01990
uniprot id: U3TCU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

1198449:ACAM RS03305
gene id: 1198449:ACAM_RS03305
uniprot id: U3T9D8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

1198449:ACAM RS01305
gene id: 1198449:ACAM_RS01305
uniprot id: U3T882
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1198449:ACAM RS07240
gene id: 1198449:ACAM_RS07240
uniprot id: U3TFS6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1198449:ACAM RS03315
gene id: 1198449:ACAM_RS03315
uniprot id: U3TFN4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

1198449:ACAM RS03220
gene id: 1198449:ACAM_RS03220
uniprot id: U3TCD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

1198449:ACAM RS06510
gene id: 1198449:ACAM_RS06510
uniprot id: U3TFJ6
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS01995
gene id: 1198449:ACAM_RS01995
uniprot id: U3TBR1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1198449:ACAM RS07520
gene id: 1198449:ACAM_RS07520
uniprot id: U3TBN6
names: Subunit
messages: Homodimer.

1198449:ACAM RS05495
gene id: 1198449:ACAM_RS05495
uniprot id: U3TDN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1198449:ACAM RS04810
gene id: 1198449:ACAM_RS04810
uniprot id: U3TDB7
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1198449:ACAM RS06185
gene id: 1198449:ACAM_RS06185
uniprot id: U3TH90
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1198449:ACAM RS04645
gene id: 1198449:ACAM_RS04645
uniprot id: U3TGD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).

1198449:ACAM RS03615
gene id: 1198449:ACAM_RS03615
uniprot id: U3TCN6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1198449:ACAM RS03595
gene id: 1198449:ACAM_RS03595
uniprot id: U3T9I7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

1198449:ACAM RS03075
gene id: 1198449:ACAM_RS03075
uniprot id: U3T967
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS00430
gene id: 1198449:ACAM_RS00430
uniprot id: U3TAV3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

1198449:ACAM RS00860
gene id: 1198449:ACAM_RS00860
uniprot id: U3TB60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

1198449:ACAM RS02065
gene id: 1198449:ACAM_RS02065
uniprot id: U3TCW1
names: Similarity
messages: Belongs to the peptidase M24B family.

1198449:ACAM RS03490
gene id: 1198449:ACAM_RS03490
uniprot id: U3TDR5
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

1198449:ACAM RS02235
gene id: 1198449:ACAM_RS02235
uniprot id: U3T8Q4
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

1198449:ACAM RS01590
gene id: 1198449:ACAM_RS01590
uniprot id: U3T8C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

1198449:ACAM RS00705
gene id: 1198449:ACAM_RS00705
uniprot id: U3TB30
names: Similarity
messages: Belongs to the UPF0235 family.

1198449:ACAM RS05025
gene id: 1198449:ACAM_RS05025
uniprot id: U3TAA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1198449:ACAM RS04675
gene id: 1198449:ACAM_RS04675
uniprot id: U3TED1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

1198449:ACAM RS04585
gene id: 1198449:ACAM_RS04585
uniprot id: U3TA19
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

1198449:ACAM RS06005
gene id: 1198449:ACAM_RS06005
uniprot id: U3TFA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

1198449:ACAM RS04690
gene id: 1198449:ACAM_RS04690
uniprot id: U3TEK8
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

1198449:ACAM RS00980
gene id: 1198449:ACAM_RS00980
uniprot id: U3TEB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

1198449:ACAM RS04915
gene id: 1198449:ACAM_RS04915
uniprot id: U3TA84
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS06695
gene id: 1198449:ACAM_RS06695
uniprot id: U3TFH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1198449:ACAM RS03570
gene id: 1198449:ACAM_RS03570
uniprot id: U3T9I3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1198449:ACAM RS05635
gene id: 1198449:ACAM_RS05635
uniprot id: U3TEX8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-66 and Arg-69) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

1198449:ACAM RS06385
gene id: 1198449:ACAM_RS06385
uniprot id: U3THC3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

1198449:ACAM RS05770
gene id: 1198449:ACAM_RS05770
uniprot id: U3TDX1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

1198449:ACAM RS06820
gene id: 1198449:ACAM_RS06820
uniprot id: U3TFJ7
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1198449:ACAM RS00570
gene id: 1198449:ACAM_RS00570
uniprot id: U3TC20
names: Similarity
messages: Belongs to the Nth/MutY family.

1198449:ACAM RS05545
gene id: 1198449:ACAM_RS05545
uniprot id: U3TDP7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1198449:ACAM RS01340
gene id: 1198449:ACAM_RS01340
uniprot id: U3TEI6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

1198449:ACAM RS03690
gene id: 1198449:ACAM_RS03690
uniprot id: U3TCP7
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

1198449:ACAM RS00605
gene id: 1198449:ACAM_RS00605
uniprot id: U3T7U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

1198449:ACAM RS06300
gene id: 1198449:ACAM_RS06300
uniprot id: U3TFG0
names: Similarity
messages: Belongs to the CinA family.

1198449:ACAM RS08510
gene id: 1198449:ACAM_RS08510
uniprot id: U3TI97
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS00115
gene id: 1198449:ACAM_RS00115
uniprot id: U3T7J5
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.

1198449:ACAM RS05290
gene id: 1198449:ACAM_RS05290
uniprot id: U3TGP7
names: Similarity
messages: Belongs to the CutA family.

1198449:ACAM RS07755
gene id: 1198449:ACAM_RS07755
uniprot id: U3TG73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1198449:ACAM RS05350
gene id: 1198449:ACAM_RS05350
uniprot id: U3TDL0
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS00560
gene id: 1198449:ACAM_RS00560
uniprot id: U3TCA9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

1198449:ACAM RS05890
gene id: 1198449:ACAM_RS05890
uniprot id: U3TF91
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1198449:ACAM RS02485
gene id: 1198449:ACAM_RS02485
uniprot id: U3TD48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

1198449:ACAM RS01855
gene id: 1198449:ACAM_RS01855
uniprot id: U3TCR7
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

1198449:ACAM RS07135
gene id: 1198449:ACAM_RS07135
uniprot id: U3TFQ6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1198449:ACAM RS05595
gene id: 1198449:ACAM_RS05595
uniprot id: U3TDR0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1198449:ACAM RS01035
gene id: 1198449:ACAM_RS01035
uniprot id: U3TEC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1198449:ACAM RS07775
gene id: 1198449:ACAM_RS07775
uniprot id: U3TBT4
names: Caution
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

1198449:ACAM RS03170
gene id: 1198449:ACAM_RS03170
uniprot id: U3TCC8
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS06380
gene id: 1198449:ACAM_RS06380
uniprot id: U3TFH4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

1198449:ACAM RS03685
gene id: 1198449:ACAM_RS03685
uniprot id: U3TDU3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

1198449:ACAM RS00215
gene id: 1198449:ACAM_RS00215
uniprot id: U3T7L7
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS00315
gene id: 1198449:ACAM_RS00315
uniprot id: U3T7P0
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

1198449:ACAM RS06635
gene id: 1198449:ACAM_RS06635
uniprot id: U3TFL5
names: Caution
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1198449:ACAM RS04780
gene id: 1198449:ACAM_RS04780
uniprot id: U3TEF2
names: Similarity
messages: Belongs to the UPF0273 family.

1198449:ACAM RS05295
gene id: 1198449:ACAM_RS05295
uniprot id: U3TEQ7
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1198449:ACAM RS05790
gene id: 1198449:ACAM_RS05790
uniprot id: U3TF29
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS05075
gene id: 1198449:ACAM_RS05075
uniprot id: U3TDG5
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

1198449:ACAM RS06785
gene id: 1198449:ACAM_RS06785
uniprot id: U3TFP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

1198449:ACAM RS01645
gene id: 1198449:ACAM_RS01645
uniprot id: U3T8D5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1198449:ACAM RS00025
gene id: 1198449:ACAM_RS00025
uniprot id: U3TDN3
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS03770
gene id: 1198449:ACAM_RS03770
uniprot id: U3T9L2
names: Similarity
messages: Belongs to the SDO1/SBDS family.

1198449:ACAM RS01485
gene id: 1198449:ACAM_RS01485
uniprot id: U3TEL5
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1198449:ACAM RS07790
gene id: 1198449:ACAM_RS07790
uniprot id: U3TG38
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS02420
gene id: 1198449:ACAM_RS02420
uniprot id: U3TD91
names: Subcellular Location Annotation
messages: Nucleus

1198449:ACAM RS03330
gene id: 1198449:ACAM_RS03330
uniprot id: U3T9E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

1198449:ACAM RS00985
gene id: 1198449:ACAM_RS00985
uniprot id: U3TCB6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

1198449:ACAM RS04605
gene id: 1198449:ACAM_RS04605
uniprot id: U3TD76
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1198449:ACAM RS05135
gene id: 1198449:ACAM_RS05135
uniprot id: U3TEU2
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1198449:ACAM RS01350
gene id: 1198449:ACAM_RS01350
uniprot id: U3TBE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

1198449:ACAM RS02030
gene id: 1198449:ACAM_RS02030
uniprot id: U3TD19
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1198449:ACAM RS04685
gene id: 1198449:ACAM_RS04685
uniprot id: U3TA37
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

1198449:ACAM RS05565
gene id: 1198449:ACAM_RS05565
uniprot id: U3TEW1
names: Similarity
messages: Belongs to the UPF0200 family.

1198449:ACAM RS03590
gene id: 1198449:ACAM_RS03590
uniprot id: U3TCN2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

1198449:ACAM RS05515
gene id: 1198449:ACAM_RS05515
uniprot id: U3TEV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1198449:ACAM RS04600
gene id: 1198449:ACAM_RS04600
uniprot id: U3TEB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

1198449:ACAM RS04760
gene id: 1198449:ACAM_RS04760
uniprot id: U3TDA8
names: Similarity
messages: Belongs to the Ahb/Nir family.

1198449:ACAM RS02060
gene id: 1198449:ACAM_RS02060
uniprot id: U3TEW6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

1198449:ACAM RS05870
gene id: 1198449:ACAM_RS05870
uniprot id: U3TH40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

1198449:ACAM RS04670
gene id: 1198449:ACAM_RS04670
uniprot id: U3TGD7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

1198449:ACAM RS02160
gene id: 1198449:ACAM_RS02160
uniprot id: U3T8N7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

1198449:ACAM RS00730
gene id: 1198449:ACAM_RS00730
uniprot id: U3TB36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

1198449:ACAM RS03275
gene id: 1198449:ACAM_RS03275
uniprot id: U3TCG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1198449:ACAM RS06630
gene id: 1198449:ACAM_RS06630
uniprot id: U3TB59
names: Similarity
messages: Belongs to the UPF0107 family.

1198449:ACAM RS02625
gene id: 1198449:ACAM_RS02625
uniprot id: U3TD75
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1198449:ACAM RS04855
gene id: 1198449:ACAM_RS04855
uniprot id: U3TEG9
names: Similarity
messages: Belongs to the FUN14 family.

1198449:ACAM RS07705
gene id: 1198449:ACAM_RS07705
uniprot id: U3TG63
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1198449:ACAM RS05855
gene id: 1198449:ACAM_RS05855
uniprot id: U3TDY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1198449:ACAM RS01715
gene id: 1198449:ACAM_RS01715
uniprot id: U3TBK8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

1198449:ACAM RS04865
gene id: 1198449:ACAM_RS04865
uniprot id: U3TA73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1198449:ACAM RS02995
gene id: 1198449:ACAM_RS02995
uniprot id: U3TC90
names: Similarity
messages: Belongs to the UPF0175 family.

1198449:ACAM RS04560
gene id: 1198449:ACAM_RS04560
uniprot id: U3TA14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1198449:ACAM RS05300
gene id: 1198449:ACAM_RS05300
uniprot id: U3TDK4
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1198449:ACAM RS06675
gene id: 1198449:ACAM_RS06675
uniprot id: U3TEB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Cytoplasm

1198449:ACAM RS01235
gene id: 1198449:ACAM_RS01235
uniprot id: U3TCM9
names: Similarity
messages: Belongs to the RuvB family.

1198449:ACAM RS05605
gene id: 1198449:ACAM_RS05605
uniprot id: U3TF30
names: Similarity
messages: Belongs to the isopentenyl phosphate kinase family.

1198449:ACAM RS00900
gene id: 1198449:ACAM_RS00900
uniprot id: U3TEA7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1198449:ACAM RS03710
gene id: 1198449:ACAM_RS03710
uniprot id: U3TDU6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

1198449:ACAM RS08210
gene id: 1198449:ACAM_RS08210
uniprot id: U3TC27
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS00940
gene id: 1198449:ACAM_RS00940
uniprot id: U3TB71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

1198449:ACAM RS00720
gene id: 1198449:ACAM_RS00720
uniprot id: U3TE70
names: Subcellular Location Annotation
messages: Nucleus

1198449:ACAM RS06995
gene id: 1198449:ACAM_RS06995
uniprot id: U3TFT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

1198449:ACAM RS04955
gene id: 1198449:ACAM_RS04955
uniprot id: U3TGH7
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

1198449:ACAM RS03830
gene id: 1198449:ACAM_RS03830
uniprot id: U3T9M3
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

1198449:ACAM RS07570
gene id: 1198449:ACAM_RS07570
uniprot id: U3TBP7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

1198449:ACAM RS04710
gene id: 1198449:ACAM_RS04710
uniprot id: U3TA42
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

1198449:ACAM RS07560
gene id: 1198449:ACAM_RS07560
uniprot id: U3TFZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1198449:ACAM RS02740
gene id: 1198449:ACAM_RS02740
uniprot id: U3TC44
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1198449:ACAM RS05055
gene id: 1198449:ACAM_RS05055
uniprot id: U3TES6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

1198449:ACAM RS00630
gene id: 1198449:ACAM_RS00630
uniprot id: U3T7V0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

1198449:ACAM RS01165
gene id: 1198449:ACAM_RS01165
uniprot id: U3TCE4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1198449:ACAM RS02880
gene id: 1198449:ACAM_RS02880
uniprot id: U3TFB4
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS01205
gene id: 1198449:ACAM_RS01205
uniprot id: U3TCM5
names: Similarity
messages: Belongs to the peptidase C56 family.

1198449:ACAM RS05400
gene id: 1198449:ACAM_RS05400
uniprot id: U3TDL7
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1198449:ACAM RS06860
gene id: 1198449:ACAM_RS06860
uniprot id: U3TFQ9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1198449:ACAM RS07410
gene id: 1198449:ACAM_RS07410
uniprot id: U3TG05
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1198449:ACAM RS01310
gene id: 1198449:ACAM_RS01310
uniprot id: U3TCN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1198449:ACAM RS04660
gene id: 1198449:ACAM_RS04660
uniprot id: U3TA32
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

1198449:ACAM RS01330
gene id: 1198449:ACAM_RS01330
uniprot id: U3T887
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

1198449:ACAM RS07800
gene id: 1198449:ACAM_RS07800
uniprot id: U3TBU0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

1198449:ACAM RS06985
gene id: 1198449:ACAM_RS06985
uniprot id: U3TEH3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1198449:ACAM RS06465
gene id: 1198449:ACAM_RS06465
uniprot id: U3THD6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.

1198449:ACAM RS07715
gene id: 1198449:ACAM_RS07715
uniprot id: U3TG23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

1198449:ACAM RS00385
gene id: 1198449:ACAM_RS00385
uniprot id: U3T7Q4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1198449:ACAM RS00105
gene id: 1198449:ACAM_RS00105
uniprot id: U3TBR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

1198449:ACAM RS03155
gene id: 1198449:ACAM_RS03155
uniprot id: U3T980
names: Similarity
messages: Belongs to the UPF0248 family.

1198449:ACAM RS03510
gene id: 1198449:ACAM_RS03510
uniprot id: U3TFS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1198449:ACAM RS04815
gene id: 1198449:ACAM_RS04815
uniprot id: U3TA63
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

1198449:ACAM RS01395
gene id: 1198449:ACAM_RS01395
uniprot id: U3TCI3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

1198449:ACAM RS00580
gene id: 1198449:ACAM_RS00580
uniprot id: U3T7U0
names: Similarity
messages: Belongs to the CDC6/cdc18 family.

1198449:ACAM RS06145
gene id: 1198449:ACAM_RS06145
uniprot id: U3TE35
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

1198449:ACAM RS02890
gene id: 1198449:ACAM_RS02890
uniprot id: U3TC69
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

1198449:ACAM RS04180
gene id: 1198449:ACAM_RS04180
uniprot id: U3TG51
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS05365
gene id: 1198449:ACAM_RS05365
uniprot id: U3TGR3
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS00180
gene id: 1198449:ACAM_RS00180
uniprot id: U3TBT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1198449:ACAM RS07395
gene id: 1198449:ACAM_RS07395
uniprot id: U3TEQ2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

1198449:ACAM RS01495
gene id: 1198449:ACAM_RS01495
uniprot id: U3TBH1
names: Similarity
messages: Belongs to the group II decarboxylase family.

1198449:ACAM RS01755
gene id: 1198449:ACAM_RS01755
uniprot id: U3TCP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1198449:ACAM RS01490
gene id: 1198449:ACAM_RS01490
uniprot id: U3TCK2
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

1198449:ACAM RS01785
gene id: 1198449:ACAM_RS01785
uniprot id: U3TBM2
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

1198449:ACAM RS06875
gene id: 1198449:ACAM_RS06875
uniprot id: U3TEF6
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS01885
gene id: 1198449:ACAM_RS01885
uniprot id: U3TBP1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1198449:ACAM RS03335
gene id: 1198449:ACAM_RS03335
uniprot id: U3TDU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1198449:ACAM RS07195
gene id: 1198449:ACAM_RS07195
uniprot id: U3TBG8
names: Similarity
messages: Belongs to the group II decarboxylase family.

1198449:ACAM RS00100
gene id: 1198449:ACAM_RS00100
uniprot id: U3TDQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

1198449:ACAM RS00135
gene id: 1198449:ACAM_RS00135
uniprot id: U3TAP8
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS01320
gene id: 1198449:ACAM_RS01320
uniprot id: U3TCG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1198449:ACAM RS06335
gene id: 1198449:ACAM_RS06335
uniprot id: U3TFA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1198449:ACAM RS01250
gene id: 1198449:ACAM_RS01250
uniprot id: U3TBC1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1198449:ACAM RS05200
gene id: 1198449:ACAM_RS05200
uniprot id: U3TDI7
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS02950
gene id: 1198449:ACAM_RS02950
uniprot id: U3TDJ4
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

1198449:ACAM RS05745
gene id: 1198449:ACAM_RS05745
uniprot id: U3TDV5
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

1198449:ACAM RS05885
gene id: 1198449:ACAM_RS05885
uniprot id: U3TAU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

1198449:ACAM RS00755
gene id: 1198449:ACAM_RS00755
uniprot id: U3TB46
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS05915
gene id: 1198449:ACAM_RS05915
uniprot id: U3TAV4
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

1198449:ACAM RS00565
gene id: 1198449:ACAM_RS00565
uniprot id: U3TE06
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

1198449:ACAM RS07965
gene id: 1198449:ACAM_RS07965
uniprot id: U3TF04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

1198449:ACAM RS02865
gene id: 1198449:ACAM_RS02865
uniprot id: U3TC64
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

1198449:ACAM RS06790
gene id: 1198449:ACAM_RS06790
uniprot id: U3THJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

1198449:ACAM RS02145
gene id: 1198449:ACAM_RS02145
uniprot id: U3TEY0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

1198449:ACAM RS06915
gene id: 1198449:ACAM_RS06915
uniprot id: U3THL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

1198449:ACAM RS04890
gene id: 1198449:ACAM_RS04890
uniprot id: U3TA79
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

1198449:ACAM RS06750
gene id: 1198449:ACAM_RS06750
uniprot id: U3TED2
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

1198449:ACAM RS03660
gene id: 1198449:ACAM_RS03660
uniprot id: U3TDT9
names: Similarity
messages: Belongs to the UPF0173 family.

1198449:ACAM RS04665
gene id: 1198449:ACAM_RS04665
uniprot id: U3TEK3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1198449:ACAM RS01730
gene id: 1198449:ACAM_RS01730
uniprot id: U3TEQ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1198449:ACAM RS06760
gene id: 1198449:ACAM_RS06760
uniprot id: U3TFN8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1198449:ACAM RS02620
gene id: 1198449:ACAM_RS02620
uniprot id: U3TF64
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

1198449:ACAM RS05755
gene id: 1198449:ACAM_RS05755
uniprot id: U3TF73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

1198449:ACAM RS02550
gene id: 1198449:ACAM_RS02550
uniprot id: U3TC11
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

1198449:ACAM RS07490
gene id: 1198449:ACAM_RS07490
uniprot id: U3TER9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1198449:ACAM RS05535
gene id: 1198449:ACAM_RS05535
uniprot id: U3TGU9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

1198449:ACAM RS06680
gene id: 1198449:ACAM_RS06680
uniprot id: U3TB67
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1198449:ACAM RS06400
gene id: 1198449:ACAM_RS06400
uniprot id: U3TB22
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

1198449:ACAM RS07820
gene id: 1198449:ACAM_RS07820
uniprot id: U3TEY1
names: Function
messages: Part of a potassium transport system.

1198449:ACAM RS03630
gene id: 1198449:ACAM_RS03630
uniprot id: U3TFU6
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1198449:ACAM RS02510
gene id: 1198449:ACAM_RS02510
uniprot id: U3TD54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1198449:ACAM RS02135
gene id: 1198449:ACAM_RS02135
uniprot id: U3T8N2
names: Similarity
messages: Belongs to the UPRTase family.

1198449:ACAM RS05000
gene id: 1198449:ACAM_RS05000
uniprot id: U3TER7
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS01090
gene id: 1198449:ACAM_RS01090
uniprot id: U3TCK4
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

1198449:ACAM RS06610
gene id: 1198449:ACAM_RS06610
uniprot id: U3TFL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

1198449:ACAM RS05030
gene id: 1198449:ACAM_RS05030
uniprot id: U3TES2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1198449:ACAM RS00220
gene id: 1198449:ACAM_RS00220
uniprot id: U3TC39
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1198449:ACAM RS01300
gene id: 1198449:ACAM_RS01300
uniprot id: U3TBD0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1198449:ACAM RS06450
gene id: 1198449:ACAM_RS06450
uniprot id: U3TB31
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1198449:ACAM RS06460
gene id: 1198449:ACAM_RS06460
uniprot id: U3TFI5
names: Similarity
messages: Belongs to the HypE family.

1198449:ACAM RS04050
gene id: 1198449:ACAM_RS04050
uniprot id: U3T9Q7
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS00410
gene id: 1198449:ACAM_RS00410
uniprot id: U3T7Q8
names: Similarity
messages: Belongs to the HerA family.

1198449:ACAM RS05580
gene id: 1198449:ACAM_RS05580
uniprot id: U3TF25
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

1198449:ACAM RS03625
gene id: 1198449:ACAM_RS03625
uniprot id: U3TDZ7
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

1198449:ACAM RS07555
gene id: 1198449:ACAM_RS07555
uniprot id: U3THX6
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

1198449:ACAM RS08305
gene id: 1198449:ACAM_RS08305
uniprot id: U3TF98
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

1198449:ACAM RS07340
gene id: 1198449:ACAM_RS07340
uniprot id: U3THT4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

1198449:ACAM RS07695
gene id: 1198449:ACAM_RS07695
uniprot id: U3TEV8
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

1198449:ACAM RS03070
gene id: 1198449:ACAM_RS03070
uniprot id: U3TCA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1198449:ACAM RS06535
gene id: 1198449:ACAM_RS06535
uniprot id: U3TB42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1198449:ACAM RS02575
gene id: 1198449:ACAM_RS02575
uniprot id: U3TC16
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1198449:ACAM RS00185
gene id: 1198449:ACAM_RS00185
uniprot id: U3TAQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

1198449:ACAM RS06700
gene id: 1198449:ACAM_RS06700
uniprot id: U3TEC3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1198449:ACAM RS06035
gene id: 1198449:ACAM_RS06035
uniprot id: U3TH66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1198449:ACAM RS04580
gene id: 1198449:ACAM_RS04580
uniprot id: U3TD71
names: Function
messages: Probably involved in the biogenesis of the ribosome.

1198449:ACAM RS03550
gene id: 1198449:ACAM_RS03550
uniprot id: U3TDY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1198449:ACAM RS05550
gene id: 1198449:ACAM_RS05550
uniprot id: U3TAL1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1198449:ACAM RS03350
gene id: 1198449:ACAM_RS03350
uniprot id: U3TCI6
names: Similarity
messages: Belongs to the DMRL synthase family.

1198449:ACAM RS00785
gene id: 1198449:ACAM_RS00785
uniprot id: U3TB48
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

1198449:ACAM RS03600
gene id: 1198449:ACAM_RS03600
uniprot id: U3TDZ1
names: Similarity
messages: Belongs to the PDCD5 family.

1198449:ACAM RS07735
gene id: 1198449:ACAM_RS07735
uniprot id: U3TI08
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1198449:ACAM RS07940
gene id: 1198449:ACAM_RS07940
uniprot id: U3TF01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

1198449:ACAM RS05850
gene id: 1198449:ACAM_RS05850
uniprot id: U3TF37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1198449:ACAM RS05275
gene id: 1198449:ACAM_RS05275
uniprot id: U3TDJ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

1198449:ACAM RS07015
gene id: 1198449:ACAM_RS07015
uniprot id: U3TBD2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

1198449:ACAM RS07510
gene id: 1198449:ACAM_RS07510
uniprot id: U3TFY5
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS01295
gene id: 1198449:ACAM_RS01295
uniprot id: U3TCG4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1198449:ACAM RS02770
gene id: 1198449:ACAM_RS02770
uniprot id: U3T908
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1198449:ACAM RS05800
gene id: 1198449:ACAM_RS05800
uniprot id: U3TAT5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.
messages: Cytoplasm
messages: Homodimer.

1198449:ACAM RS02495
gene id: 1198449:ACAM_RS02495
uniprot id: U3T8V6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

1198449:ACAM RS05485
gene id: 1198449:ACAM_RS05485
uniprot id: U3TGT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

1198449:ACAM RS01375
gene id: 1198449:ACAM_RS01375
uniprot id: U3TBE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1198449:ACAM RS05560
gene id: 1198449:ACAM_RS05560
uniprot id: U3TGV4
names: Similarity
messages: Belongs to the UPF0201 family.

1198449:ACAM RS05455
gene id: 1198449:ACAM_RS05455
uniprot id: U3TF03
names: Similarity
messages: Belongs to the SCO1/2 family.

1198449:ACAM RS03745
gene id: 1198449:ACAM_RS03745
uniprot id: U3T9K9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

1198449:ACAM RS06945
gene id: 1198449:ACAM_RS06945
uniprot id: U3TFM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

1198449:ACAM RS05825
gene id: 1198449:ACAM_RS05825
uniprot id: U3TAT7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1198449:ACAM RS01360
gene id: 1198449:ACAM_RS01360
uniprot id: U3TCP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1198449:ACAM RS02735
gene id: 1198449:ACAM_RS02735
uniprot id: U3TD99
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

1198449:ACAM RS04860
gene id: 1198449:ACAM_RS04860
uniprot id: U3TDC7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

1198449:ACAM RS05520
gene id: 1198449:ACAM_RS05520
uniprot id: U3TDP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1198449:ACAM RS07905
gene id: 1198449:ACAM_RS07905
uniprot id: U3TI42
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

1198449:ACAM RS07550
gene id: 1198449:ACAM_RS07550
uniprot id: U3TG35
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

1198449:ACAM RS00050
gene id: 1198449:ACAM_RS00050
uniprot id: U3TDN9
names: Similarity
messages: Belongs to the FGGY kinase family.

1198449:ACAM RS01680
gene id: 1198449:ACAM_RS01680
uniprot id: U3TEP9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

1198449:ACAM RS00555
gene id: 1198449:ACAM_RS00555
uniprot id: U3T7T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1198449:ACAM RS03000
gene id: 1198449:ACAM_RS03000
uniprot id: U3T953
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS06900
gene id: 1198449:ACAM_RS06900
uniprot id: U3TEG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1198449:ACAM RS00865
gene id: 1198449:ACAM_RS00865
uniprot id: U3T818
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1198449:ACAM RS05305
gene id: 1198449:ACAM_RS05305
uniprot id: U3TAF6
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

1198449:ACAM RS03160
gene id: 1198449:ACAM_RS03160
uniprot id: U3TFI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1198449:ACAM RS04530
gene id: 1198449:ACAM_RS04530
uniprot id: U3TD62
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

1198449:ACAM RS05705
gene id: 1198449:ACAM_RS05705
uniprot id: U3TGY9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

1198449:ACAM RS01050
gene id: 1198449:ACAM_RS01050
uniprot id: U3TB85
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

1198449:ACAM RS03525
gene id: 1198449:ACAM_RS03525
uniprot id: U3T9H5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1198449:ACAM RS06180
gene id: 1198449:ACAM_RS06180
uniprot id: U3TFD7
names: Similarity
messages: Belongs to the ZPR1 family.

1198449:ACAM RS05420
gene id: 1198449:ACAM_RS05420
uniprot id: U3TET1
names: Similarity
messages: Belongs to the citrate synthase family.

1198449:ACAM RS00030
gene id: 1198449:ACAM_RS00030
uniprot id: U3TBP8
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

1198449:ACAM RS02915
gene id: 1198449:ACAM_RS02915
uniprot id: U3TC74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

1198449:ACAM RS02600
gene id: 1198449:ACAM_RS02600
uniprot id: U3TD70
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1198449:ACAM RS04380
gene id: 1198449:ACAM_RS04380
uniprot id: U3TD31
names: Subcellular Location Annotation
messages: Membrane

1198449:ACAM RS03975
gene id: 1198449:ACAM_RS03975
uniprot id: U3TCV1
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).