113653:GAH RS09270
gene id: 113653:GAH_RS09270
uniprot id: A0A0F7IEM2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

113653:GAH RS10000
gene id: 113653:GAH_RS10000
uniprot id: A0A0F7IFT3
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

113653:GAH RS00530
gene id: 113653:GAH_RS00530
uniprot id: A0A0F7II90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

113653:GAH RS07765
gene id: 113653:GAH_RS07765
uniprot id: A0A0F7IEP8
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS07410
gene id: 113653:GAH_RS07410
uniprot id: A0A0F7DBJ7
names: Similarity
messages: Belongs to the UPF0175 family.

113653:GAH RS00985
gene id: 113653:GAH_RS00985
uniprot id: A0A0F7IHN0
names: Similarity
messages: Belongs to the HypD family.

113653:GAH RS00745
gene id: 113653:GAH_RS00745
uniprot id: A0A0F7IJS4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

113653:GAH RS07145
gene id: 113653:GAH_RS07145
uniprot id: A0A0F7IH15
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS06460
gene id: 113653:GAH_RS06460
uniprot id: A0A0F7DBN3
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS00955
gene id: 113653:GAH_RS00955
uniprot id: A0A0F7IHN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

113653:GAH RS07665
gene id: 113653:GAH_RS07665
uniprot id: A0A0F7IGU2
names: Similarity
messages: Belongs to the thymidylate kinase family.

113653:GAH RS09790
gene id: 113653:GAH_RS09790
uniprot id: A0A0F7IEE7
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

113653:GAH RS09970
gene id: 113653:GAH_RS09970
uniprot id: A0A0F7IEB7
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

113653:GAH RS05210
gene id: 113653:GAH_RS05210
uniprot id: A0A0F7IHY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

113653:GAH RS06990
gene id: 113653:GAH_RS06990
uniprot id: A0A0F7IF07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

113653:GAH RS04505
gene id: 113653:GAH_RS04505
uniprot id: A0A0F7IIE9
names: Similarity
messages: Belongs to the UPF0215 family.

113653:GAH RS08710
gene id: 113653:GAH_RS08710
uniprot id: A0A0F7DBE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

113653:GAH RS09940
gene id: 113653:GAH_RS09940
uniprot id: A0A0F7IFT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

113653:GAH RS02675
gene id: 113653:GAH_RS02675
uniprot id: A0A0F7IG09
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS00890
gene id: 113653:GAH_RS00890
uniprot id: A0A0F7IHN8
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

113653:GAH RS05615
gene id: 113653:GAH_RS05615
uniprot id: A0A0F7IHR4
names: Similarity
messages: Belongs to the archaeal-type GPI family.

113653:GAH RS00450
gene id: 113653:GAH_RS00450
uniprot id: A0A0F7IGY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

113653:GAH RS04370
gene id: 113653:GAH_RS04370
uniprot id: A0A0F7DBW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

113653:GAH RS07645
gene id: 113653:GAH_RS07645
uniprot id: A0A0F7IER7
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

113653:GAH RS05635
gene id: 113653:GAH_RS05635
uniprot id: A0A0F7DBR4
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

113653:GAH RS04735
gene id: 113653:GAH_RS04735
uniprot id: A0A0F7IGG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

113653:GAH RS01840
gene id: 113653:GAH_RS01840
uniprot id: A0A0F7IGC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

113653:GAH RS08205
gene id: 113653:GAH_RS08205
uniprot id: A0A0F7DBG6
names: Similarity
messages: Belongs to the glutamine synthetase family.

113653:GAH RS01885
gene id: 113653:GAH_RS01885
uniprot id: A0A0F7IJ61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

113653:GAH RS05700
gene id: 113653:GAH_RS05700
uniprot id: A0A0F7IEU4
names: Similarity
messages: Belongs to the BtpA family.

113653:GAH RS09770
gene id: 113653:GAH_RS09770
uniprot id: A0A0F7ICY3
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

113653:GAH RS08705
gene id: 113653:GAH_RS08705
uniprot id: A0A0F7IEX1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

113653:GAH RS00525
gene id: 113653:GAH_RS00525
uniprot id: A0A0F7IJW8
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

113653:GAH RS02085
gene id: 113653:GAH_RS02085
uniprot id: A0A0F7IH52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

113653:GAH RS02120
gene id: 113653:GAH_RS02120
uniprot id: A0A0F7IG88
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

113653:GAH RS00945
gene id: 113653:GAH_RS00945
uniprot id: A0A0F7DC96
names: Similarity
messages: Belongs to the band 7/mec-2 family.

113653:GAH RS09795
gene id: 113653:GAH_RS09795
uniprot id: A0A0F7IDQ9
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS09565
gene id: 113653:GAH_RS09565
uniprot id: A0A0F7IEI0
names: Similarity
messages: Belongs to the SUI1 family.

113653:GAH RS05470
gene id: 113653:GAH_RS05470
uniprot id: A0A0F7IFG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the oxidation of methyl-H(4)MPT to methylene-H(4)MPT.
messages: Cytoplasm

113653:GAH RS03705
gene id: 113653:GAH_RS03705
uniprot id: A0A0F7IEG2
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

113653:GAH RS01565
gene id: 113653:GAH_RS01565
uniprot id: A0A0F7IFA3
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

113653:GAH RS00425
gene id: 113653:GAH_RS00425
uniprot id: A0A0F7IG92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

113653:GAH RS00205
gene id: 113653:GAH_RS00205
uniprot id: A0A0F7IGB7
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS09280
gene id: 113653:GAH_RS09280
uniprot id: A0A0F7ID51
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

113653:GAH RS04415
gene id: 113653:GAH_RS04415
uniprot id: A0A0F7IIG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

113653:GAH RS07770
gene id: 113653:GAH_RS07770
uniprot id: A0A0F7DBI3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

113653:GAH RS06175
gene id: 113653:GAH_RS06175
uniprot id: A0A0F7IEM3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

113653:GAH RS06900
gene id: 113653:GAH_RS06900
uniprot id: A0A0F7IF22
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

113653:GAH RS08820
gene id: 113653:GAH_RS08820
uniprot id: A0A0F7IGD3
names: Similarity
messages: Belongs to the TrpC family.

113653:GAH RS07445
gene id: 113653:GAH_RS07445
uniprot id: A0A0F7IEU3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

113653:GAH RS08185
gene id: 113653:GAH_RS08185
uniprot id: A0A0F7IEE1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

113653:GAH RS01905
gene id: 113653:GAH_RS01905
uniprot id: A0A0F7IGB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

113653:GAH RS02955
gene id: 113653:GAH_RS02955
uniprot id: A0A0F7IHB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

113653:GAH RS08940
gene id: 113653:GAH_RS08940
uniprot id: A0A0F7ICD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

113653:GAH RS06935
gene id: 113653:GAH_RS06935
uniprot id: A0A0F7IEB8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

113653:GAH RS09715
gene id: 113653:GAH_RS09715
uniprot id: A0A0F7IFW3
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

113653:GAH RS08485
gene id: 113653:GAH_RS08485
uniprot id: A0A0F7IDN0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

113653:GAH RS02935
gene id: 113653:GAH_RS02935
uniprot id: A0A0F7IEQ6
names: Similarity
messages: Belongs to the HerA family.

113653:GAH RS04170
gene id: 113653:GAH_RS04170
uniprot id: A0A0F7IGQ3
names: Subunit
messages: Homodimer.

113653:GAH RS05315
gene id: 113653:GAH_RS05315
uniprot id: A0A0F7IHX8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

113653:GAH RS07575
gene id: 113653:GAH_RS07575
uniprot id: A0A0F7DBJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

113653:GAH RS01815
gene id: 113653:GAH_RS01815
uniprot id: A0A0F7IF69
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS08530
gene id: 113653:GAH_RS08530
uniprot id: A0A0F7IGF7
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

113653:GAH RS06950
gene id: 113653:GAH_RS06950
uniprot id: A0A0F7IH43
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

113653:GAH RS08900
gene id: 113653:GAH_RS08900
uniprot id: A0A0F7IDB2
names: Similarity
messages: Belongs to the MEMO1 family.

113653:GAH RS02395
gene id: 113653:GAH_RS02395
uniprot id: A0A0F7IGZ9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

113653:GAH RS09215
gene id: 113653:GAH_RS09215
uniprot id: A0A0F7IDX8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

113653:GAH RS01790
gene id: 113653:GAH_RS01790
uniprot id: A0A0F7IJ79
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

113653:GAH RS07650
gene id: 113653:GAH_RS07650
uniprot id: A0A0F7DBI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

113653:GAH RS05085
gene id: 113653:GAH_RS05085
uniprot id: A0A0F7IFJ6
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

113653:GAH RS03235
gene id: 113653:GAH_RS03235
uniprot id: A0A0F7IEL5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-65 and Arg-68) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

113653:GAH RS08520
gene id: 113653:GAH_RS08520
uniprot id: A0A0F7DBF4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS03665
gene id: 113653:GAH_RS03665
uniprot id: A0A0F7IFL3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

113653:GAH RS07865
gene id: 113653:GAH_RS07865
uniprot id: A0A0F7DBH9
names: Similarity
messages: Belongs to the HepT RNase toxin family.

113653:GAH RS02615
gene id: 113653:GAH_RS02615
uniprot id: A0A0F7DC30
names: Similarity
messages: Belongs to the class-I fumarase family.

113653:GAH RS00570
gene id: 113653:GAH_RS00570
uniprot id: A0A0F7IHS0
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

113653:GAH RS04475
gene id: 113653:GAH_RS04475
uniprot id: A0A0F7IE47
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

113653:GAH RS06020
gene id: 113653:GAH_RS06020
uniprot id: A0A0F7IFC3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

113653:GAH RS08850
gene id: 113653:GAH_RS08850
uniprot id: A0A0F7IGC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

113653:GAH RS08675
gene id: 113653:GAH_RS08675
uniprot id: A0A0F7IGE9
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

113653:GAH RS03215
gene id: 113653:GAH_RS03215
uniprot id: A0A0F7IH61
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

113653:GAH RS07675
gene id: 113653:GAH_RS07675
uniprot id: A0A0F7DBI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

113653:GAH RS02415
gene id: 113653:GAH_RS02415
uniprot id: A0A0F7IEX9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

113653:GAH RS00840
gene id: 113653:GAH_RS00840
uniprot id: A0A0F7DCA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

113653:GAH RS00005
gene id: 113653:GAH_RS00005
uniprot id: A0A0F7IK40
names: Similarity
messages: Belongs to the threonine synthase family.

113653:GAH RS03965
gene id: 113653:GAH_RS03965
uniprot id: A0A0F7DBX9
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

113653:GAH RS09305
gene id: 113653:GAH_RS09305
uniprot id: A0A0F7IDW9
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS07630
gene id: 113653:GAH_RS07630
uniprot id: A0A0F7ID09
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPase class C family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm

113653:GAH RS04185
gene id: 113653:GAH_RS04185
uniprot id: A0A0F7IE91
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

113653:GAH RS04465
gene id: 113653:GAH_RS04465
uniprot id: A0A0F7IFB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

113653:GAH RS08855
gene id: 113653:GAH_RS08855
uniprot id: A0A0F7DBE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

113653:GAH RS06235
gene id: 113653:GAH_RS06235
uniprot id: A0A0F7DBP2
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

113653:GAH RS05810
gene id: 113653:GAH_RS05810
uniprot id: A0A0F7IDJ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

113653:GAH RS06180
gene id: 113653:GAH_RS06180
uniprot id: A0A0F7DBP4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

113653:GAH RS08720
gene id: 113653:GAH_RS08720
uniprot id: A0A0F7IDH0
names: Function
names: Similarity
messages: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

113653:GAH RS03735
gene id: 113653:GAH_RS03735
uniprot id: A0A0F7IEF4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

113653:GAH RS00600
gene id: 113653:GAH_RS00600
uniprot id: A0A0F7II83
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

113653:GAH RS09655
gene id: 113653:GAH_RS09655
uniprot id: A0A0F7IFW7
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS04875
gene id: 113653:GAH_RS04875
uniprot id: A0A0F7DBU3
names: Similarity
messages: Belongs to the acylphosphatase family.

113653:GAH RS10630
gene id: 113653:GAH_RS10630
uniprot id: A0A0F7IGB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

113653:GAH RS02925
gene id: 113653:GAH_RS02925
uniprot id: A0A0F7DC18
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

113653:GAH RS06215
gene id: 113653:GAH_RS06215
uniprot id: A0A0F7IDF0
names: Similarity
messages: Belongs to the ZPR1 family.

113653:GAH RS07035
gene id: 113653:GAH_RS07035
uniprot id: A0A0F7ID84
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

113653:GAH RS02310
gene id: 113653:GAH_RS02310
uniprot id: A0A0F7IG56
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS04350
gene id: 113653:GAH_RS04350
uniprot id: A0A0F7IE66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

113653:GAH RS00315
gene id: 113653:GAH_RS00315
uniprot id: A0A0F7DCC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

113653:GAH RS04675
gene id: 113653:GAH_RS04675
uniprot id: A0A0F7DBV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

113653:GAH RS03530
gene id: 113653:GAH_RS03530
uniprot id: A0A0F7DBZ6
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

113653:GAH RS10405
gene id: 113653:GAH_RS10405
uniprot id: A0A0F7IF35
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

113653:GAH RS07340
gene id: 113653:GAH_RS07340
uniprot id: A0A0F7IGY2
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS02940
gene id: 113653:GAH_RS02940
uniprot id: A0A0F7IIT4
names: Similarity
messages: Belongs to the UPF0212 family.

113653:GAH RS09260
gene id: 113653:GAH_RS09260
uniprot id: A0A0F7DBC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

113653:GAH RS05110
gene id: 113653:GAH_RS05110
uniprot id: A0A0F7IGA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

113653:GAH RS03115
gene id: 113653:GAH_RS03115
uniprot id: A0A0F7DC11
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

113653:GAH RS00935
gene id: 113653:GAH_RS00935
uniprot id: A0A0F7IFX7
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS02990
gene id: 113653:GAH_RS02990
uniprot id: A0A0F7DC16
names: Similarity
messages: Belongs to the SDO1/SBDS family.

113653:GAH RS01920
gene id: 113653:GAH_RS01920
uniprot id: A0A0F7IHN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

113653:GAH RS08760
gene id: 113653:GAH_RS08760
uniprot id: A0A0F7DBE5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

113653:GAH RS03650
gene id: 113653:GAH_RS03650
uniprot id: A0A0F7DBZ1
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS05045
gene id: 113653:GAH_RS05045
uniprot id: A0A0F7DBT6
names: Similarity
messages: Belongs to the UPF0310 family.

113653:GAH RS02130
gene id: 113653:GAH_RS02130
uniprot id: A0A0F7IF23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

113653:GAH RS00755
gene id: 113653:GAH_RS00755
uniprot id: A0A0F7IHQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

113653:GAH RS00365
gene id: 113653:GAH_RS00365
uniprot id: A0A0F7DCB9
names: Similarity
messages: Belongs to the CutA family.

113653:GAH RS00540
gene id: 113653:GAH_RS00540
uniprot id: A0A0F7IHS4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

113653:GAH RS07885
gene id: 113653:GAH_RS07885
uniprot id: A0A0F7IEN0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

113653:GAH RS07140
gene id: 113653:GAH_RS07140
uniprot id: A0A0F7ID70
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS03015
gene id: 113653:GAH_RS03015
uniprot id: A0A0F7DC15
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

113653:GAH RS02850
gene id: 113653:GAH_RS02850
uniprot id: A0A0F7IIU4
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

113653:GAH RS01695
gene id: 113653:GAH_RS01695
uniprot id: A0A0F7IF92
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS06155
gene id: 113653:GAH_RS06155
uniprot id: A0A0F7DBP5
names: Similarity
messages: Belongs to the MtrH family.

113653:GAH RS02230
gene id: 113653:GAH_RS02230
uniprot id: A0A0F7IHK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Membrane

113653:GAH RS04525
gene id: 113653:GAH_RS04525
uniprot id: A0A0F7IFB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

113653:GAH RS02905
gene id: 113653:GAH_RS02905
uniprot id: A0A0F7IER1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

113653:GAH RS05150
gene id: 113653:GAH_RS05150
uniprot id: A0A0F7IFI3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

113653:GAH RS06390
gene id: 113653:GAH_RS06390
uniprot id: A0A0F7IF89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

113653:GAH RS05880
gene id: 113653:GAH_RS05880
uniprot id: A0A0F7IHM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

113653:GAH RS06250
gene id: 113653:GAH_RS06250
uniprot id: A0A0F7IEL4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

113653:GAH RS01485
gene id: 113653:GAH_RS01485
uniprot id: A0A0F7IHW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

113653:GAH RS04885
gene id: 113653:GAH_RS04885
uniprot id: A0A0F7IDV7
names: Similarity
messages: Belongs to the RutC family.

113653:GAH RS06340
gene id: 113653:GAH_RS06340
uniprot id: A0A0F7IEK2
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

113653:GAH RS00490
gene id: 113653:GAH_RS00490
uniprot id: A0A0F7IG73
names: Similarity
messages: Belongs to the MoaB/Mog family.

113653:GAH RS01830
gene id: 113653:GAH_RS01830
uniprot id: A0A0F7IHR1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

113653:GAH RS09910
gene id: 113653:GAH_RS09910
uniprot id: A0A0F7IFU5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

113653:GAH RS09205
gene id: 113653:GAH_RS09205
uniprot id: A0A0F7IEN4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

113653:GAH RS02660
gene id: 113653:GAH_RS02660
uniprot id: A0A0F7IHF0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

113653:GAH RS05355
gene id: 113653:GAH_RS05355
uniprot id: A0A0F7IG78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

113653:GAH RS08955
gene id: 113653:GAH_RS08955
uniprot id: A0A0F7DBD7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

113653:GAH RS08775
gene id: 113653:GAH_RS08775
uniprot id: A0A0F7IDF7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

113653:GAH RS00495
gene id: 113653:GAH_RS00495
uniprot id: A0A0F7IJX9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

113653:GAH RS07305
gene id: 113653:GAH_RS07305
uniprot id: A0A0F7IGY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

113653:GAH RS04865
gene id: 113653:GAH_RS04865
uniprot id: A0A0F7IGD7
names: Similarity
messages: Belongs to the UPF0166 family.

113653:GAH RS04250
gene id: 113653:GAH_RS04250
uniprot id: A0A0F7IE80
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

113653:GAH RS05360
gene id: 113653:GAH_RS05360
uniprot id: A0A0F7IFH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

113653:GAH RS09520
gene id: 113653:GAH_RS09520
uniprot id: A0A0F7IC54
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

113653:GAH RS04495
gene id: 113653:GAH_RS04495
uniprot id: A0A0F7DBV8
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

113653:GAH RS03290
gene id: 113653:GAH_RS03290
uniprot id: A0A0F7IFU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

113653:GAH RS09830
gene id: 113653:GAH_RS09830
uniprot id: A0A0F7DBA3
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

113653:GAH RS00865
gene id: 113653:GAH_RS00865
uniprot id: A0A0F7IGS4
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS04800
gene id: 113653:GAH_RS04800
uniprot id: A0A0F7IGF5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

113653:GAH RS01555
gene id: 113653:GAH_RS01555
uniprot id: A0A0F7IHB9
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

113653:GAH RS03200
gene id: 113653:GAH_RS03200
uniprot id: A0A0F7IFU3
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

113653:GAH RS02655
gene id: 113653:GAH_RS02655
uniprot id: A0A0F7IIX2
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

113653:GAH RS09235
gene id: 113653:GAH_RS09235
uniprot id: A0A0F7IG71
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

113653:GAH RS02000
gene id: 113653:GAH_RS02000
uniprot id: A0A0F7DC54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

113653:GAH RS07310
gene id: 113653:GAH_RS07310
uniprot id: A0A0F7DBK1
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

113653:GAH RS04485
gene id: 113653:GAH_RS04485
uniprot id: A0A0F7IGL3
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

113653:GAH RS02175
gene id: 113653:GAH_RS02175
uniprot id: A0A0F7DC47
names: Similarity
messages: Belongs to the P(II) protein family.

113653:GAH RS07685
gene id: 113653:GAH_RS07685
uniprot id: A0A0F7IE14
names: Similarity
messages: Belongs to the glutaredoxin family.

113653:GAH RS03940
gene id: 113653:GAH_RS03940
uniprot id: A0A0F7DBY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

113653:GAH RS10370
gene id: 113653:GAH_RS10370
uniprot id: A0A0F7DBP1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

113653:GAH RS00555
gene id: 113653:GAH_RS00555
uniprot id: A0A0F7IJW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

113653:GAH RS09580
gene id: 113653:GAH_RS09580
uniprot id: A0A0F7ID12
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

113653:GAH RS04600
gene id: 113653:GAH_RS04600
uniprot id: A0A0F7IIE0
names: Similarity
messages: Belongs to the glutaredoxin family.

113653:GAH RS08670
gene id: 113653:GAH_RS08670
uniprot id: A0A0F7ICG9
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

113653:GAH RS08745
gene id: 113653:GAH_RS08745
uniprot id: A0A0F7IE46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

113653:GAH RS02780
gene id: 113653:GAH_RS02780
uniprot id: A0A0F7IES8
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS01290
gene id: 113653:GAH_RS01290
uniprot id: A0A0F7IJI6
names: Similarity
messages: Belongs to the citrate synthase family.

113653:GAH RS05680
gene id: 113653:GAH_RS05680
uniprot id: A0A0F7IG39
names: Similarity
messages: Belongs to the archease family.

113653:GAH RS10400
gene id: 113653:GAH_RS10400
uniprot id: A0A0F7IFR6
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

113653:GAH RS03795
gene id: 113653:GAH_RS03795
uniprot id: A0A0F7IEE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

113653:GAH RS09150
gene id: 113653:GAH_RS09150
uniprot id: A0A0F7IDY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

113653:GAH RS01745
gene id: 113653:GAH_RS01745
uniprot id: A0A0F7IH89
names: Similarity
messages: Belongs to the peptidase M20A family.

113653:GAH RS03310
gene id: 113653:GAH_RS03310
uniprot id: A0A0F7IH18
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS04195
gene id: 113653:GAH_RS04195
uniprot id: A0A0F7IIK1
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

113653:GAH RS01910
gene id: 113653:GAH_RS01910
uniprot id: A0A0F7IF55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

113653:GAH RS01520
gene id: 113653:GAH_RS01520
uniprot id: A0A0F7IHC0
names: Subcellular Location Annotation
messages: Cell membrane

113653:GAH RS00455
gene id: 113653:GAH_RS00455
uniprot id: A0A0F7IG89
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

113653:GAH RS10050
gene id: 113653:GAH_RS10050
uniprot id: A0A0F7ICU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

113653:GAH RS04665
gene id: 113653:GAH_RS04665
uniprot id: A0A0F7IE13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

113653:GAH RS02610
gene id: 113653:GAH_RS02610
uniprot id: A0A0F7IEV1
names: Similarity
messages: Belongs to the class-I fumarase family.

113653:GAH RS08190
gene id: 113653:GAH_RS08190
uniprot id: A0A0F7IDS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

113653:GAH RS10180
gene id: 113653:GAH_RS10180
uniprot id: A0A0F7ICS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

113653:GAH RS04790
gene id: 113653:GAH_RS04790
uniprot id: A0A0F7II45
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

113653:GAH RS07625
gene id: 113653:GAH_RS07625
uniprot id: A0A0F7DBI9
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

113653:GAH RS09410
gene id: 113653:GAH_RS09410
uniprot id: A0A0F7ID31
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

113653:GAH RS03660
gene id: 113653:GAH_RS03660
uniprot id: A0A0F7IGG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

113653:GAH RS04920
gene id: 113653:GAH_RS04920
uniprot id: A0A0F7DBU1
names: Similarity
messages: Belongs to the DtxR/MntR family.

113653:GAH RS05970
gene id: 113653:GAH_RS05970
uniprot id: A0A0F7IHI7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

113653:GAH RS02010
gene id: 113653:GAH_RS02010
uniprot id: A0A0F7IJ52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

113653:GAH RS03725
gene id: 113653:GAH_RS03725
uniprot id: A0A0F7DBY8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS04245
gene id: 113653:GAH_RS04245
uniprot id: A0A0F7IFD6
names: Function
messages: Part of a potassium transport system.

113653:GAH RS08735
gene id: 113653:GAH_RS08735
uniprot id: A0A0F7DBE6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

113653:GAH RS06700
gene id: 113653:GAH_RS06700
uniprot id: A0A0F7IH71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

113653:GAH RS08400
gene id: 113653:GAH_RS08400
uniprot id: A0A0F7IGH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

113653:GAH RS07980
gene id: 113653:GAH_RS07980
uniprot id: A0A0F7IF85
names: Similarity
messages: Belongs to the peptidase S45 family.

113653:GAH RS05340
gene id: 113653:GAH_RS05340
uniprot id: A0A0F7IDQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

113653:GAH RS04470
gene id: 113653:GAH_RS04470
uniprot id: A0A0F7DBV9
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

113653:GAH RS05490
gene id: 113653:GAH_RS05490
uniprot id: A0A0F7IG59
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

113653:GAH RS04940
gene id: 113653:GAH_RS04940
uniprot id: A0A0F7IDV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

113653:GAH RS03695
gene id: 113653:GAH_RS03695
uniprot id: A0A0F7IFL2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

113653:GAH RS09030
gene id: 113653:GAH_RS09030
uniprot id: A0A0F7ID93
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

113653:GAH RS01810
gene id: 113653:GAH_RS01810
uniprot id: A0A0F7IGC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

113653:GAH RS05755
gene id: 113653:GAH_RS05755
uniprot id: A0A0F7IG37
names: Function
names: Similarity
messages: Belongs to the UPF0330 family.
messages: Possibly the antitoxin component of a toxin-antitoxin (TA) module.

113653:GAH RS02115
gene id: 113653:GAH_RS02115
uniprot id: A0A0F7IH49
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

113653:GAH RS09165
gene id: 113653:GAH_RS09165
uniprot id: A0A0F7ICA4
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

113653:GAH RS06205
gene id: 113653:GAH_RS06205
uniprot id: A0A0F7DBP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

113653:GAH RS00715
gene id: 113653:GAH_RS00715
uniprot id: A0A0F7IJT0
names: Caution
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS07055
gene id: 113653:GAH_RS07055
uniprot id: A0A0F7IF01
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS05200
gene id: 113653:GAH_RS05200
uniprot id: A0A0F7IDR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

113653:GAH RS03280
gene id: 113653:GAH_RS03280
uniprot id: A0A0F7IH30
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

113653:GAH RS08175
gene id: 113653:GAH_RS08175
uniprot id: A0A0F7IF51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

113653:GAH RS02560
gene id: 113653:GAH_RS02560
uniprot id: A0A0F7IHG0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

113653:GAH RS00910
gene id: 113653:GAH_RS00910
uniprot id: A0A0F7IJQ3
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

113653:GAH RS04280
gene id: 113653:GAH_RS04280
uniprot id: A0A0F7IE76
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

113653:GAH RS00340
gene id: 113653:GAH_RS00340
uniprot id: A0A0F7DCC0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS09295
gene id: 113653:GAH_RS09295
uniprot id: A0A0F7IG53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

113653:GAH RS01305
gene id: 113653:GAH_RS01305
uniprot id: A0A0F7IHI6
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

113653:GAH RS00980
gene id: 113653:GAH_RS00980
uniprot id: A0A0F7II48
names: Similarity
messages: Belongs to the HupF/HypC family.

113653:GAH RS04325
gene id: 113653:GAH_RS04325
uniprot id: A0A0F7IIH1
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

113653:GAH RS06630
gene id: 113653:GAH_RS06630
uniprot id: A0A0F7IDC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

113653:GAH RS09585
gene id: 113653:GAH_RS09585
uniprot id: A0A0F7IC44
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

113653:GAH RS03135
gene id: 113653:GAH_RS03135
uniprot id: A0A0F7IFW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT).
messages: Cytoplasm
messages: Homotetramer.

113653:GAH RS02585
gene id: 113653:GAH_RS02585
uniprot id: A0A0F7IIX8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

113653:GAH RS01925
gene id: 113653:GAH_RS01925
uniprot id: A0A0F7DC57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

113653:GAH RS02570
gene id: 113653:GAH_RS02570
uniprot id: A0A0F7IGY6
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

113653:GAH RS08020
gene id: 113653:GAH_RS08020
uniprot id: A0A0F7DBH3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

113653:GAH RS02125
gene id: 113653:GAH_RS02125
uniprot id: A0A0F7DC49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

113653:GAH RS00355
gene id: 113653:GAH_RS00355
uniprot id: A0A0F7IHU7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS01780
gene id: 113653:GAH_RS01780
uniprot id: A0A0F7IGD0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

113653:GAH RS01300
gene id: 113653:GAH_RS01300
uniprot id: A0A0F7DC82
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

113653:GAH RS04795
gene id: 113653:GAH_RS04795
uniprot id: A0A0F7DBU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

113653:GAH RS05670
gene id: 113653:GAH_RS05670
uniprot id: A0A0F7IDK8
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

113653:GAH RS08585
gene id: 113653:GAH_RS08585
uniprot id: A0A0F7IDI9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

113653:GAH RS07250
gene id: 113653:GAH_RS07250
uniprot id: A0A0F7IFJ1
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

113653:GAH RS09095
gene id: 113653:GAH_RS09095
uniprot id: A0A0F7ID83
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS05330
gene id: 113653:GAH_RS05330
uniprot id: A0A0F7IFH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

113653:GAH RS03645
gene id: 113653:GAH_RS03645
uniprot id: A0A0F7IIN5
names: Similarity
messages: Belongs to the GARS family.

113653:GAH RS05410
gene id: 113653:GAH_RS05410
uniprot id: A0A0F7IDN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

113653:GAH RS06275
gene id: 113653:GAH_RS06275
uniprot id: A0A0F7IFA2
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS08975
gene id: 113653:GAH_RS08975
uniprot id: A0A0F7ICD0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

113653:GAH RS08325
gene id: 113653:GAH_RS08325
uniprot id: A0A0F7IDQ6
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS06065
gene id: 113653:GAH_RS06065
uniprot id: A0A0F7IFC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

113653:GAH RS00445
gene id: 113653:GAH_RS00445
uniprot id: A0A0F7IHT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

113653:GAH RS09625
gene id: 113653:GAH_RS09625
uniprot id: A0A0F7DBB1
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

113653:GAH RS03655
gene id: 113653:GAH_RS03655
uniprot id: A0A0F7IGX3
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

113653:GAH RS07060
gene id: 113653:GAH_RS07060
uniprot id: A0A0F7IE99
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

113653:GAH RS00520
gene id: 113653:GAH_RS00520
uniprot id: A0A0F7IG66
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

113653:GAH RS04775
gene id: 113653:GAH_RS04775
uniprot id: A0A0F7IFP7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

113653:GAH RS08025
gene id: 113653:GAH_RS08025
uniprot id: A0A0F7IDU9
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

113653:GAH RS08260
gene id: 113653:GAH_RS08260
uniprot id: A0A0F7DBG4
names: Similarity
messages: Belongs to the glutamate synthase family.

113653:GAH RS01680
gene id: 113653:GAH_RS01680
uniprot id: A0A0F7DC67
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

113653:GAH RS08335
gene id: 113653:GAH_RS08335
uniprot id: A0A0F7IGH8
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

113653:GAH RS02320
gene id: 113653:GAH_RS02320
uniprot id: A0A0F7IJ10
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

113653:GAH RS01295
gene id: 113653:GAH_RS01295
uniprot id: A0A0F7IHZ8
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

113653:GAH RS07915
gene id: 113653:GAH_RS07915
uniprot id: A0A0F7DBH7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

113653:GAH RS04085
gene id: 113653:GAH_RS04085
uniprot id: A0A0F7IFE5
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

113653:GAH RS02760
gene id: 113653:GAH_RS02760
uniprot id: A0A0F7IHD7
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

113653:GAH RS08795
gene id: 113653:GAH_RS08795
uniprot id: A0A0F7IEV5
names: Similarity
messages: Belongs to the SAICAR synthetase family.

113653:GAH RS09505
gene id: 113653:GAH_RS09505
uniprot id: A0A0F7IEI9
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

113653:GAH RS04425
gene id: 113653:GAH_RS04425
uniprot id: A0A0F7IGM4
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

113653:GAH RS07430
gene id: 113653:GAH_RS07430
uniprot id: A0A0F7IGW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

113653:GAH RS04780
gene id: 113653:GAH_RS04780
uniprot id: A0A0F7IF87
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

113653:GAH RS02055
gene id: 113653:GAH_RS02055
uniprot id: A0A0F7IH55
names: Similarity
messages: Belongs to the AOR/FOR family.

113653:GAH RS03800
gene id: 113653:GAH_RS03800
uniprot id: A0A0F7DBY5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

113653:GAH RS08885
gene id: 113653:GAH_RS08885
uniprot id: A0A0F7IGC3
names: Similarity
messages: Belongs to the phosphoribulokinase family.

113653:GAH RS03375
gene id: 113653:GAH_RS03375
uniprot id: A0A0F7DC01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

113653:GAH RS03355
gene id: 113653:GAH_RS03355
uniprot id: A0A0F7IFS5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

113653:GAH RS05660
gene id: 113653:GAH_RS05660
uniprot id: A0A0F7DBR3
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

113653:GAH RS03900
gene id: 113653:GAH_RS03900
uniprot id: A0A0F7IIM0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

113653:GAH RS08405
gene id: 113653:GAH_RS08405
uniprot id: A0A0F7IF14
names: Similarity
messages: Belongs to the RuvB family.

113653:GAH RS07325
gene id: 113653:GAH_RS07325
uniprot id: A0A0F7IE60
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

113653:GAH RS00335
gene id: 113653:GAH_RS00335
uniprot id: A0A0F7IGA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

113653:GAH RS00740
gene id: 113653:GAH_RS00740
uniprot id: A0A0F7IG46
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

113653:GAH RS04225
gene id: 113653:GAH_RS04225
uniprot id: A0A0F7IIJ9
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

113653:GAH RS08150
gene id: 113653:GAH_RS08150
uniprot id: A0A0F7IDT0
names: Similarity
messages: Belongs to the HepT RNase toxin family.

113653:GAH RS02360
gene id: 113653:GAH_RS02360
uniprot id: A0A0F7IHI2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

113653:GAH RS05610
gene id: 113653:GAH_RS05610
uniprot id: A0A0F7DBR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

113653:GAH RS05760
gene id: 113653:GAH_RS05760
uniprot id: A0A0F7IFE8
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

113653:GAH RS06185
gene id: 113653:GAH_RS06185
uniprot id: A0A0F7IDF1
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

113653:GAH RS01500
gene id: 113653:GAH_RS01500
uniprot id: A0A0F7DC74
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

113653:GAH RS01935
gene id: 113653:GAH_RS01935
uniprot id: A0A0F7IGB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

113653:GAH RS07100
gene id: 113653:GAH_RS07100
uniprot id: A0A0F7IE93
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS02855
gene id: 113653:GAH_RS02855
uniprot id: A0A0F7DC21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

113653:GAH RS08995
gene id: 113653:GAH_RS08995
uniprot id: A0A0F7IE05
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

113653:GAH RS05785
gene id: 113653:GAH_RS05785
uniprot id: A0A0F7IHP9
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

113653:GAH RS04310
gene id: 113653:GAH_RS04310
uniprot id: A0A0F7IFD2
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

113653:GAH RS02825
gene id: 113653:GAH_RS02825
uniprot id: A0A0F7IHD3
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

113653:GAH RS00405
gene id: 113653:GAH_RS00405
uniprot id: A0A0F7IJZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

113653:GAH RS00400
gene id: 113653:GAH_RS00400
uniprot id: A0A0F7IG95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

113653:GAH RS05005
gene id: 113653:GAH_RS05005
uniprot id: A0A0F7II05
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS09285
gene id: 113653:GAH_RS09285
uniprot id: A0A0F7DBC4
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

113653:GAH RS02790
gene id: 113653:GAH_RS02790
uniprot id: A0A0F7IHD5
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS07985
gene id: 113653:GAH_RS07985
uniprot id: A0A0F7IEH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

113653:GAH RS03230
gene id: 113653:GAH_RS03230
uniprot id: A0A0F7IFU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

113653:GAH RS01650
gene id: 113653:GAH_RS01650
uniprot id: A0A0F7IHA5
names: Similarity
messages: Belongs to the TPP enzyme family.

113653:GAH RS03950
gene id: 113653:GAH_RS03950
uniprot id: A0A0F7IGS8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

113653:GAH RS10635
gene id: 113653:GAH_RS10635
uniprot id: A0A0F7DC59
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

113653:GAH RS08840
gene id: 113653:GAH_RS08840
uniprot id: A0A0F7IDD0
names: Similarity
messages: Belongs to the TrpF family.

113653:GAH RS00805
gene id: 113653:GAH_RS00805
uniprot id: A0A0F7IJR6
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS08090
gene id: 113653:GAH_RS08090
uniprot id: A0A0F7ICQ9
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

113653:GAH RS03065
gene id: 113653:GAH_RS03065
uniprot id: A0A0F7DC13
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

113653:GAH RS05945
gene id: 113653:GAH_RS05945
uniprot id: A0A0F7IG17
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

113653:GAH RS00690
gene id: 113653:GAH_RS00690
uniprot id: A0A0F7II73
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

113653:GAH RS00420
gene id: 113653:GAH_RS00420
uniprot id: A0A0F7IGY7
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

113653:GAH RS08950
gene id: 113653:GAH_RS08950
uniprot id: A0A0F7IES7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

113653:GAH RS02250
gene id: 113653:GAH_RS02250
uniprot id: A0A0F7IJ20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

113653:GAH RS08790
gene id: 113653:GAH_RS08790
uniprot id: A0A0F7IGD9
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class II subfamily.
messages: Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

113653:GAH RS09535
gene id: 113653:GAH_RS09535
uniprot id: A0A0F7IEI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

113653:GAH RS08945
gene id: 113653:GAH_RS08945
uniprot id: A0A0F7IGA8
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

113653:GAH RS09325
gene id: 113653:GAH_RS09325
uniprot id: A0A0F7IG51
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

113653:GAH RS04850
gene id: 113653:GAH_RS04850
uniprot id: A0A0F7DBU4
names: Similarity
messages: Belongs to the TlyA family.

113653:GAH RS02715
gene id: 113653:GAH_RS02715
uniprot id: A0A0F7IIV4
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS01855
gene id: 113653:GAH_RS01855
uniprot id: A0A0F7IJ63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

113653:GAH RS05570
gene id: 113653:GAH_RS05570
uniprot id: A0A0F7IDL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

113653:GAH RS03640
gene id: 113653:GAH_RS03640
uniprot id: A0A0F7IEG9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS07420
gene id: 113653:GAH_RS07420
uniprot id: A0A0F7IE48
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS02705
gene id: 113653:GAH_RS02705
uniprot id: A0A0F7IG04
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

113653:GAH RS09350
gene id: 113653:GAH_RS09350
uniprot id: A0A0F7IC78
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

113653:GAH RS01465
gene id: 113653:GAH_RS01465
uniprot id: A0A0F7IGH5
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

113653:GAH RS00735
gene id: 113653:GAH_RS00735
uniprot id: A0A0F7DCA4
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

113653:GAH RS03630
gene id: 113653:GAH_RS03630
uniprot id: A0A0F7IGG3
names: Similarity
messages: Belongs to the UPF0179 family.

113653:GAH RS05220
gene id: 113653:GAH_RS05220
uniprot id: A0A0F7IG93
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS00550
gene id: 113653:GAH_RS00550
uniprot id: A0A0F7IG64
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS03755
gene id: 113653:GAH_RS03755
uniprot id: A0A0F7IGE7
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

113653:GAH RS00095
gene id: 113653:GAH_RS00095
uniprot id: A0A0F7IIE3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS02590
gene id: 113653:GAH_RS02590
uniprot id: A0A0F7DC31
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

113653:GAH RS06590
gene id: 113653:GAH_RS06590
uniprot id: A0A0F7DBM8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

113653:GAH RS06300
gene id: 113653:GAH_RS06300
uniprot id: A0A0F7IFV9
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

113653:GAH RS04230
gene id: 113653:GAH_RS04230
uniprot id: A0A0F7IGP8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

113653:GAH RS02625
gene id: 113653:GAH_RS02625
uniprot id: A0A0F7IHF1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

113653:GAH RS02105
gene id: 113653:GAH_RS02105
uniprot id: A0A0F7IJ33
names: Similarity
messages: Belongs to the group II decarboxylase family.

113653:GAH RS02665
gene id: 113653:GAH_RS02665
uniprot id: A0A0F7IGX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

113653:GAH RS07425
gene id: 113653:GAH_RS07425
uniprot id: A0A0F7ID34
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS07280
gene id: 113653:GAH_RS07280
uniprot id: A0A0F7IFI9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

113653:GAH RS00295
gene id: 113653:GAH_RS00295
uniprot id: A0A0F7IHV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

113653:GAH RS00395
gene id: 113653:GAH_RS00395
uniprot id: A0A0F7IGZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

113653:GAH RS05140
gene id: 113653:GAH_RS05140
uniprot id: A0A0F7IG99
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

113653:GAH RS08365
gene id: 113653:GAH_RS08365
uniprot id: A0A0F7DBG0
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the oxidation of methylene-H(4)MPT to methenyl-H(4)MPT(+).

113653:GAH RS09185
gene id: 113653:GAH_RS09185
uniprot id: A0A0F7DBC8
names: Similarity
messages: Belongs to the AOR/FOR family.

113653:GAH RS06260
gene id: 113653:GAH_RS06260
uniprot id: A0A0F7IHD1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

113653:GAH RS02700
gene id: 113653:GAH_RS02700
uniprot id: A0A0F7IGW4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

113653:GAH RS05105
gene id: 113653:GAH_RS05105
uniprot id: A0A0F7IHZ0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

113653:GAH RS08430
gene id: 113653:GAH_RS08430
uniprot id: A0A0F7IGG8
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

113653:GAH RS06440
gene id: 113653:GAH_RS06440
uniprot id: A0A0F7IDD4
names: Similarity
messages: Belongs to the malic enzymes family.

113653:GAH RS01950
gene id: 113653:GAH_RS01950
uniprot id: A0A0F7IHM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

113653:GAH RS01010
gene id: 113653:GAH_RS01010
uniprot id: A0A0F7II43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
messages: Cell membrane
messages: Membrane

113653:GAH RS02975
gene id: 113653:GAH_RS02975
uniprot id: A0A0F7IEQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

113653:GAH RS09835
gene id: 113653:GAH_RS09835
uniprot id: A0A0F7ICX4
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS06660
gene id: 113653:GAH_RS06660
uniprot id: A0A0F7IDB9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

113653:GAH RS06890
gene id: 113653:GAH_RS06890
uniprot id: A0A0F7IFM5
names: Similarity
messages: Belongs to the AAA ATPase family.

113653:GAH RS09935
gene id: 113653:GAH_RS09935
uniprot id: A0A0F7IBZ0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS00485
gene id: 113653:GAH_RS00485
uniprot id: A0A0F7DCB4
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

113653:GAH RS04815
gene id: 113653:GAH_RS04815
uniprot id: A0A0F7IF84
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

113653:GAH RS03820
gene id: 113653:GAH_RS03820
uniprot id: A0A0F7IFK7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

113653:GAH RS00620
gene id: 113653:GAH_RS00620
uniprot id: A0A0F7IJV1
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

113653:GAH RS04770
gene id: 113653:GAH_RS04770
uniprot id: A0A0F7DBU7
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

113653:GAH RS09200
gene id: 113653:GAH_RS09200
uniprot id: A0A0F7IG72
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

113653:GAH RS03970
gene id: 113653:GAH_RS03970
uniprot id: A0A0F7IEC1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

113653:GAH RS01425
gene id: 113653:GAH_RS01425
uniprot id: A0A0F7DC77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

113653:GAH RS02335
gene id: 113653:GAH_RS02335
uniprot id: A0A0F7IH20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

113653:GAH RS04480
gene id: 113653:GAH_RS04480
uniprot id: A0A0F7IIG5
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

113653:GAH RS09065
gene id: 113653:GAH_RS09065
uniprot id: A0A0F7ID87
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS03680
gene id: 113653:GAH_RS03680
uniprot id: A0A0F7IIN3
names: Similarity
messages: Belongs to the UPF0111 family.

113653:GAH RS04950
gene id: 113653:GAH_RS04950
uniprot id: A0A0F7II22
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

113653:GAH RS08765
gene id: 113653:GAH_RS08765
uniprot id: A0A0F7IGE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

113653:GAH RS10110
gene id: 113653:GAH_RS10110
uniprot id: A0A0F7DB92
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

113653:GAH RS07815
gene id: 113653:GAH_RS07815
uniprot id: A0A0F7DBI1
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

113653:GAH RS05405
gene id: 113653:GAH_RS05405
uniprot id: A0A0F7IEY9
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.

113653:GAH RS04150
gene id: 113653:GAH_RS04150
uniprot id: A0A0F7IFE2
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS08005
gene id: 113653:GAH_RS08005
uniprot id: A0A0F7IGL4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

113653:GAH RS04285
gene id: 113653:GAH_RS04285
uniprot id: A0A0F7IIH2
names: Similarity
messages: Belongs to the peptidase M24B family.

113653:GAH RS04490
gene id: 113653:GAH_RS04490
uniprot id: A0A0F7IFX8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

113653:GAH RS04995
gene id: 113653:GAH_RS04995
uniprot id: A0A0F7IF54
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

113653:GAH RS04565
gene id: 113653:GAH_RS04565
uniprot id: A0A0F7DBV5
names: Similarity
messages: Belongs to the UPF0047 family.

113653:GAH RS09195
gene id: 113653:GAH_RS09195
uniprot id: A0A0F7ICA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

113653:GAH RS05320
gene id: 113653:GAH_RS05320
uniprot id: A0A0F7DBS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

113653:GAH RS01800
gene id: 113653:GAH_RS01800
uniprot id: A0A0F7DC62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

113653:GAH RS00730
gene id: 113653:GAH_RS00730
uniprot id: A0A0F7IGV3
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

113653:GAH RS01845
gene id: 113653:GAH_RS01845
uniprot id: A0A0F7IF64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

113653:GAH RS10120
gene id: 113653:GAH_RS10120
uniprot id: A0A0F7ICT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

113653:GAH RS05365
gene id: 113653:GAH_RS05365
uniprot id: A0A0F7IEZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

113653:GAH RS01915
gene id: 113653:GAH_RS01915
uniprot id: A0A0F7IJ59
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

113653:GAH RS10340
gene id: 113653:GAH_RS10340
uniprot id: A0A0F7IHX3
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.

113653:GAH RS05230
gene id: 113653:GAH_RS05230
uniprot id: A0A0F7IF16
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

113653:GAH RS09765
gene id: 113653:GAH_RS09765
uniprot id: A0A0F7IDR3
names: Similarity
messages: Belongs to the DMRL synthase family.

113653:GAH RS09120
gene id: 113653:GAH_RS09120
uniprot id: A0A0F7IDY8
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

113653:GAH RS05640
gene id: 113653:GAH_RS05640
uniprot id: A0A0F7IDL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

113653:GAH RS07775
gene id: 113653:GAH_RS07775
uniprot id: A0A0F7IE04
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

113653:GAH RS09905
gene id: 113653:GAH_RS09905
uniprot id: A0A0F7DBA0
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS05455
gene id: 113653:GAH_RS05455
uniprot id: A0A0F7IHW8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS04945
gene id: 113653:GAH_RS04945
uniprot id: A0A0F7DBU0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

113653:GAH RS01860
gene id: 113653:GAH_RS01860
uniprot id: A0A0F7IHQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

113653:GAH RS05345
gene id: 113653:GAH_RS05345
uniprot id: A0A0F7DBS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

113653:GAH RS00680
gene id: 113653:GAH_RS00680
uniprot id: A0A0F7IJU2
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

113653:GAH RS04900
gene id: 113653:GAH_RS04900
uniprot id: A0A0F7DBU2
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS03010
gene id: 113653:GAH_RS03010
uniprot id: A0A0F7IEP6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

113653:GAH RS05915
gene id: 113653:GAH_RS05915
uniprot id: A0A0F7IG19
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS09245
gene id: 113653:GAH_RS09245
uniprot id: A0A0F7IEM8
names: Similarity
messages: Belongs to the aspartokinase family.

113653:GAH RS05135
gene id: 113653:GAH_RS05135
uniprot id: A0A0F7IHY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

113653:GAH RS08305
gene id: 113653:GAH_RS08305
uniprot id: A0A0F7IGI0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS08800
gene id: 113653:GAH_RS08800
uniprot id: A0A0F7IE36
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

113653:GAH RS10485
gene id: 113653:GAH_RS10485
uniprot id: A0A0F7IED6
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

113653:GAH RS06740
gene id: 113653:GAH_RS06740
uniprot id: A0A0F7IFS6
names: Similarity
messages: Belongs to the UPF0310 family.

113653:GAH RS05080
gene id: 113653:GAH_RS05080
uniprot id: A0A0F7IGA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

113653:GAH RS01380
gene id: 113653:GAH_RS01380
uniprot id: A0A0F7IFP0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

113653:GAH RS05725
gene id: 113653:GAH_RS05725
uniprot id: A0A0F7IG38
names: Similarity
messages: Belongs to the FwdC/FmdC family.

113653:GAH RS05500
gene id: 113653:GAH_RS05500
uniprot id: A0A0F7IEX4
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS00970
gene id: 113653:GAH_RS00970
uniprot id: A0A0F7DC95
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

113653:GAH RS05120
gene id: 113653:GAH_RS05120
uniprot id: A0A0F7DBT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

113653:GAH RS04545
gene id: 113653:GAH_RS04545
uniprot id: A0A0F7IGK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

113653:GAH RS00825
gene id: 113653:GAH_RS00825
uniprot id: A0A0F7IGS6
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

113653:GAH RS09540
gene id: 113653:GAH_RS09540
uniprot id: A0A0F7IDU1
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS03075
gene id: 113653:GAH_RS03075
uniprot id: A0A0F7IEN6
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

113653:GAH RS03220
gene id: 113653:GAH_RS03220
uniprot id: A0A0F7DC07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

113653:GAH RS09775
gene id: 113653:GAH_RS09775
uniprot id: A0A0F7IC14
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

113653:GAH RS03995
gene id: 113653:GAH_RS03995
uniprot id: A0A0F7IFH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

113653:GAH RS05480
gene id: 113653:GAH_RS05480
uniprot id: A0A0F7IDM8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

113653:GAH RS01570
gene id: 113653:GAH_RS01570
uniprot id: A0A0F7IJB9
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS00310
gene id: 113653:GAH_RS00310
uniprot id: A0A0F7IK01
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

113653:GAH RS05310
gene id: 113653:GAH_RS05310
uniprot id: A0A0F7IDQ4
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

113653:GAH RS07870
gene id: 113653:GAH_RS07870
uniprot id: A0A0F7ICX3
names: Similarity
messages: Belongs to the UPF0284 family.

113653:GAH RS09605
gene id: 113653:GAH_RS09605
uniprot id: A0A0F7IDT3
names: Similarity
messages: Belongs to the UPF0175 family.

113653:GAH RS01445
gene id: 113653:GAH_RS01445
uniprot id: A0A0F7IJD3
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS09425
gene id: 113653:GAH_RS09425
uniprot id: A0A0F7IG07
names: Similarity
messages: Belongs to the UPF0173 family.

113653:GAH RS04720
gene id: 113653:GAH_RS04720
uniprot id: A0A0F7DBU9
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

113653:GAH RS07255
gene id: 113653:GAH_RS07255
uniprot id: A0A0F7IEX2
names: Similarity
messages: Belongs to the polysaccharide synthase family.

113653:GAH RS00475
gene id: 113653:GAH_RS00475
uniprot id: A0A0F7IHT1
names: Caution
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS06360
gene id: 113653:GAH_RS06360
uniprot id: A0A0F7DBN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

113653:GAH RS00720
gene id: 113653:GAH_RS00720
uniprot id: A0A0F7II70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

113653:GAH RS02840
gene id: 113653:GAH_RS02840
uniprot id: A0A0F7IFZ8
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

113653:GAH RS05130
gene id: 113653:GAH_RS05130
uniprot id: A0A0F7IDS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

113653:GAH RS08740
gene id: 113653:GAH_RS08740
uniprot id: A0A0F7IEW6
names: Similarity
messages: Belongs to the P(II) protein family.

113653:GAH RS09745
gene id: 113653:GAH_RS09745
uniprot id: A0A0F7IFV5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

113653:GAH RS00300
gene id: 113653:GAH_RS00300
uniprot id: A0A0F7IH06
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

113653:GAH RS06045
gene id: 113653:GAH_RS06045
uniprot id: A0A0F7IDG5
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS08525
gene id: 113653:GAH_RS08525
uniprot id: A0A0F7ICJ0
names: Similarity
messages: Belongs to the UPF0045 family.

113653:GAH RS01820
gene id: 113653:GAH_RS01820
uniprot id: A0A0F7IJ65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

113653:GAH RS04975
gene id: 113653:GAH_RS04975
uniprot id: A0A0F7II17
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS01895
gene id: 113653:GAH_RS01895
uniprot id: A0A0F7IH63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

113653:GAH RS06970
gene id: 113653:GAH_RS06970
uniprot id: A0A0F7DBL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

113653:GAH RS00230
gene id: 113653:GAH_RS00230
uniprot id: A0A0F7IH14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

113653:GAH RS07450
gene id: 113653:GAH_RS07450
uniprot id: A0A0F7IE43
names: Similarity
messages: Belongs to the UPF0251 family.

113653:GAH RS07195
gene id: 113653:GAH_RS07195
uniprot id: A0A0F7IE79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

113653:GAH RS04550
gene id: 113653:GAH_RS04550
uniprot id: A0A0F7IFX4
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS08245
gene id: 113653:GAH_RS08245
uniprot id: A0A0F7IF39
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

113653:GAH RS05845
gene id: 113653:GAH_RS05845
uniprot id: A0A0F7IHN9
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

113653:GAH RS06160
gene id: 113653:GAH_RS06160
uniprot id: A0A0F7IHD8
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

113653:GAH RS06910
gene id: 113653:GAH_RS06910
uniprot id: A0A0F7IDA1
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS01365
gene id: 113653:GAH_RS01365
uniprot id: A0A0F7IHG8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

113653:GAH RS00790
gene id: 113653:GAH_RS00790
uniprot id: A0A0F7IHQ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

113653:GAH RS02160
gene id: 113653:GAH_RS02160
uniprot id: A0A0F7IF18
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

113653:GAH RS05905
gene id: 113653:GAH_RS05905
uniprot id: A0A0F7IDI4
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS04730
gene id: 113653:GAH_RS04730
uniprot id: A0A0F7II53
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

113653:GAH RS08890
gene id: 113653:GAH_RS08890
uniprot id: A0A0F7IET9
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS03445
gene id: 113653:GAH_RS03445
uniprot id: A0A0F7IIQ0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

113653:GAH RS05380
gene id: 113653:GAH_RS05380
uniprot id: A0A0F7IHX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

113653:GAH RS03430
gene id: 113653:GAH_RS03430
uniprot id: A0A0F7IFP6
names: Similarity
messages: Belongs to the UPF0235 family.

113653:GAH RS00960
gene id: 113653:GAH_RS00960
uniprot id: A0A0F7IGR7
names: Similarity
messages: Belongs to the HypE family.

113653:GAH RS09130
gene id: 113653:GAH_RS09130
uniprot id: A0A0F7ICA8
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

113653:GAH RS01850
gene id: 113653:GAH_RS01850
uniprot id: A0A0F7DC60
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

113653:GAH RS00070
gene id: 113653:GAH_RS00070
uniprot id: A0A0F7IHY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

113653:GAH RS03895
gene id: 113653:GAH_RS03895
uniprot id: A0A0F7IED2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

113653:GAH RS02300
gene id: 113653:GAH_RS02300
uniprot id: A0A0F7IHI5
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS01945
gene id: 113653:GAH_RS01945
uniprot id: A0A0F7DC56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

113653:GAH RS00830
gene id: 113653:GAH_RS00830
uniprot id: A0A0F7IG06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

113653:GAH RS02355
gene id: 113653:GAH_RS02355
uniprot id: A0A0F7IJ07
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

113653:GAH RS01385
gene id: 113653:GAH_RS01385
uniprot id: A0A0F7IJH2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

113653:GAH RS00215
gene id: 113653:GAH_RS00215
uniprot id: A0A0F7IK15
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

113653:GAH RS00655
gene id: 113653:GAH_RS00655
uniprot id: A0A0F7II75
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

113653:GAH RS06510
gene id: 113653:GAH_RS06510
uniprot id: A0A0F7DBN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

113653:GAH RS01350
gene id: 113653:GAH_RS01350
uniprot id: A0A0F7DC80
names: Similarity
messages: Belongs to the UPF0248 family.

113653:GAH RS06620
gene id: 113653:GAH_RS06620
uniprot id: A0A0F7IF58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

113653:GAH RS01020
gene id: 113653:GAH_RS01020
uniprot id: A0A0F7DC93
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS02165
gene id: 113653:GAH_RS02165
uniprot id: A0A0F7IJ27
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS07265
gene id: 113653:GAH_RS07265
uniprot id: A0A0F7IE70
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

113653:GAH RS08825
gene id: 113653:GAH_RS08825
uniprot id: A0A0F7IEV0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS05975
gene id: 113653:GAH_RS05975
uniprot id: A0A0F7DBQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

113653:GAH RS01880
gene id: 113653:GAH_RS01880
uniprot id: A0A0F7IF59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

113653:GAH RS03975
gene id: 113653:GAH_RS03975
uniprot id: A0A0F7IIL5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS06465
gene id: 113653:GAH_RS06465
uniprot id: A0A0F7IEI6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

113653:GAH RS00075
gene id: 113653:GAH_RS00075
uniprot id: A0A0F7IH34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

113653:GAH RS05305
gene id: 113653:GAH_RS05305
uniprot id: A0A0F7IF06
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

113653:GAH RS02155
gene id: 113653:GAH_RS02155
uniprot id: A0A0F7IG81
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

113653:GAH RS00750
gene id: 113653:GAH_RS00750
uniprot id: A0A0F7II68
names: Similarity
messages: Belongs to the PDCD5 family.

113653:GAH RS01995
gene id: 113653:GAH_RS01995
uniprot id: A0A0F7IGA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

113653:GAH RS02540
gene id: 113653:GAH_RS02540
uniprot id: A0A0F7DC33
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

113653:GAH RS07875
gene id: 113653:GAH_RS07875
uniprot id: A0A0F7IGS1
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

113653:GAH RS04985
gene id: 113653:GAH_RS04985
uniprot id: A0A0F7IFL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

113653:GAH RS01960
gene id: 113653:GAH_RS01960
uniprot id: A0A0F7IGA5
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

113653:GAH RS06285
gene id: 113653:GAH_RS06285
uniprot id: A0A0F7IDE6
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS02965
gene id: 113653:GAH_RS02965
uniprot id: A0A0F7IGP9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

113653:GAH RS02875
gene id: 113653:GAH_RS02875
uniprot id: A0A0F7DC20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

113653:GAH RS01605
gene id: 113653:GAH_RS01605
uniprot id: A0A0F7DC70
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS05425
gene id: 113653:GAH_RS05425
uniprot id: A0A0F7DBS2
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

113653:GAH RS09155
gene id: 113653:GAH_RS09155
uniprot id: A0A0F7ID73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

113653:GAH RS03285
gene id: 113653:GAH_RS03285
uniprot id: A0A0F7IGJ8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

113653:GAH RS08970
gene id: 113653:GAH_RS08970
uniprot id: A0A0F7IDA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

113653:GAH RS01460
gene id: 113653:GAH_RS01460
uniprot id: A0A0F7IHC4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

113653:GAH RS02765
gene id: 113653:GAH_RS02765
uniprot id: A0A0F7IGU9
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

113653:GAH RS08395
gene id: 113653:GAH_RS08395
uniprot id: A0A0F7ICL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

113653:GAH RS07795
gene id: 113653:GAH_RS07795
uniprot id: A0A0F7IEP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Homodimer.

113653:GAH RS04360
gene id: 113653:GAH_RS04360
uniprot id: A0A0F7IGM9
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

113653:GAH RS04205
gene id: 113653:GAH_RS04205
uniprot id: A0A0F7IG28
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

113653:GAH RS08875
gene id: 113653:GAH_RS08875
uniprot id: A0A0F7ICE1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

113653:GAH RS09125
gene id: 113653:GAH_RS09125
uniprot id: A0A0F7ID78
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

113653:GAH RS09000
gene id: 113653:GAH_RS09000
uniprot id: A0A0F7ID97
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

113653:GAH RS04010
gene id: 113653:GAH_RS04010
uniprot id: A0A0F7IGS3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS05125
gene id: 113653:GAH_RS05125
uniprot id: A0A0F7IF31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

113653:GAH RS07485
gene id: 113653:GAH_RS07485
uniprot id: A0A0F7DBJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic Ku family.
messages: Homodimer. Interacts with LigD.
messages: With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

113653:GAH RS07415
gene id: 113653:GAH_RS07415
uniprot id: A0A0F7IEU8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

113653:GAH RS04240
gene id: 113653:GAH_RS04240
uniprot id: A0A0F7DBW8
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS08930
gene id: 113653:GAH_RS08930
uniprot id: A0A0F7DBD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

113653:GAH RS05745
gene id: 113653:GAH_RS05745
uniprot id: A0A0F7DBR0
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

113653:GAH RS09275
gene id: 113653:GAH_RS09275
uniprot id: A0A0F7IDX2
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

113653:GAH RS04880
gene id: 113653:GAH_RS04880
uniprot id: A0A0F7IF75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

113653:GAH RS04960
gene id: 113653:GAH_RS04960
uniprot id: A0A0F7IFL9
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS02255
gene id: 113653:GAH_RS02255
uniprot id: A0A0F7IHJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

113653:GAH RS07660
gene id: 113653:GAH_RS07660
uniprot id: A0A0F7ID05
names: Subunit
messages: Homotetramer.

113653:GAH RS00035
gene id: 113653:GAH_RS00035
uniprot id: A0A0F7IGD4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS04635
gene id: 113653:GAH_RS04635
uniprot id: A0A0F7IID7
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

113653:GAH RS05205
gene id: 113653:GAH_RS05205
uniprot id: A0A0F7DBT0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

113653:GAH RS03675
gene id: 113653:GAH_RS03675
uniprot id: A0A0F7DBZ0
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

113653:GAH RS05520
gene id: 113653:GAH_RS05520
uniprot id: A0A0F7IG47
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

113653:GAH RS10845
gene id: 113653:GAH_RS10845
uniprot id: A0A0F7IH02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

113653:GAH RS02145
gene id: 113653:GAH_RS02145
uniprot id: A0A0F7IH44
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

113653:GAH RS07040
gene id: 113653:GAH_RS07040
uniprot id: A0A0F7IH35
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

113653:GAH RS04405
gene id: 113653:GAH_RS04405
uniprot id: A0A0F7IFB9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

113653:GAH RS06430
gene id: 113653:GAH_RS06430
uniprot id: A0A0F7IEJ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

113653:GAH RS10840
gene id: 113653:GAH_RS10840
uniprot id: A0A0F7IHV1
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS00645
gene id: 113653:GAH_RS00645
uniprot id: A0A0F7IG57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

113653:GAH RS06170
gene id: 113653:GAH_RS06170
uniprot id: A0A0F7IFA8
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

113653:GAH RS03935
gene id: 113653:GAH_RS03935
uniprot id: A0A0F7IEC7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

113653:GAH RS01285
gene id: 113653:GAH_RS01285
uniprot id: A0A0F7IFQ8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

113653:GAH RS10135
gene id: 113653:GAH_RS10135
uniprot id: A0A0F7DB91
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

113653:GAH RS03295
gene id: 113653:GAH_RS03295
uniprot id: A0A0F7DC04
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS02425
gene id: 113653:GAH_RS02425
uniprot id: A0A0F7IHH3
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

113653:GAH RS09620
gene id: 113653:GAH_RS09620
uniprot id: A0A0F7IFW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

113653:GAH RS09720
gene id: 113653:GAH_RS09720
uniprot id: A0A0F7IEF7
names: Similarity
messages: Belongs to the UPF0047 family.

113653:GAH RS09975
gene id: 113653:GAH_RS09975
uniprot id: A0A0F7DB97
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

113653:GAH RS01770
gene id: 113653:GAH_RS01770
uniprot id: A0A0F7IH80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

113653:GAH RS02995
gene id: 113653:GAH_RS02995
uniprot id: A0A0F7IHB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

113653:GAH RS05535
gene id: 113653:GAH_RS05535
uniprot id: A0A0F7IEW8
names: Similarity
messages: Belongs to the UPF0200 family.
messages: Belongs to the UPF0201 family.

113653:GAH RS05160
gene id: 113653:GAH_RS05160
uniprot id: A0A0F7IDS3
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

113653:GAH RS04935
gene id: 113653:GAH_RS04935
uniprot id: A0A0F7IF65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

113653:GAH RS05655
gene id: 113653:GAH_RS05655
uniprot id: A0A0F7IFF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex.

113653:GAH RS03410
gene id: 113653:GAH_RS03410
uniprot id: A0A0F7DC00
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

113653:GAH RS04035
gene id: 113653:GAH_RS04035
uniprot id: A0A0F7IIL0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

113653:GAH RS02645
gene id: 113653:GAH_RS02645
uniprot id: A0A0F7DC29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

113653:GAH RS10090
gene id: 113653:GAH_RS10090
uniprot id: A0A0F7ICU0
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

113653:GAH RS08805
gene id: 113653:GAH_RS08805
uniprot id: A0A0F7DBE3
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS00665
gene id: 113653:GAH_RS00665
uniprot id: A0A0F7IHQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

113653:GAH RS09035
gene id: 113653:GAH_RS09035
uniprot id: A0A0F7DBD4
names: Similarity
messages: Belongs to the TPP enzyme family.

113653:GAH RS07965
gene id: 113653:GAH_RS07965
uniprot id: A0A0F7ICS3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

113653:GAH RS01890
gene id: 113653:GAH_RS01890
uniprot id: A0A0F7IHP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

113653:GAH RS01965
gene id: 113653:GAH_RS01965
uniprot id: A0A0F7IF46
names: Similarity
messages: Belongs to the UPF0252 family.

113653:GAH RS08830
gene id: 113653:GAH_RS08830
uniprot id: A0A0F7DBE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

113653:GAH RS05665
gene id: 113653:GAH_RS05665
uniprot id: A0A0F7IEU9
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

113653:GAH RS07095
gene id: 113653:GAH_RS07095
uniprot id: A0A0F7IEZ6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS03905
gene id: 113653:GAH_RS03905
uniprot id: A0A0F7DBY1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

113653:GAH RS01270
gene id: 113653:GAH_RS01270
uniprot id: A0A0F7IHI9
names: Similarity
messages: Belongs to the group II decarboxylase family.

113653:GAH RS00670
gene id: 113653:GAH_RS00670
uniprot id: A0A0F7IGW5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

113653:GAH RS01470
gene id: 113653:GAH_RS01470
uniprot id: A0A0F7IFE3
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

113653:GAH RS09190
gene id: 113653:GAH_RS09190
uniprot id: A0A0F7ID68
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

113653:GAH RS01055
gene id: 113653:GAH_RS01055
uniprot id: A0A0F7IGN8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

113653:GAH RS03080
gene id: 113653:GAH_RS03080
uniprot id: A0A0F7IIS7
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

113653:GAH RS05605
gene id: 113653:GAH_RS05605
uniprot id: A0A0F7IDL3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS02315
gene id: 113653:GAH_RS02315
uniprot id: A0A0F7IEZ3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

113653:GAH RS02650
gene id: 113653:GAH_RS02650
uniprot id: A0A0F7IEU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

113653:GAH RS05815
gene id: 113653:GAH_RS05815
uniprot id: A0A0F7IHP7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

113653:GAH RS04760
gene id: 113653:GAH_RS04760
uniprot id: A0A0F7II49
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

113653:GAH RS08065
gene id: 113653:GAH_RS08065
uniprot id: A0A0F7IGK6
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

113653:GAH RS00390
gene id: 113653:GAH_RS00390
uniprot id: A0A0F7DCB8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

113653:GAH RS08140
gene id: 113653:GAH_RS08140
uniprot id: A0A0F7IEE9
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

113653:GAH RS03070
gene id: 113653:GAH_RS03070
uniprot id: A0A0F7IFY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

113653:GAH RS02170
gene id: 113653:GAH_RS02170
uniprot id: A0A0F7IHK9
names: Cofactor
messages: Binds 1 zinc ion per subunit.

113653:GAH RS01835
gene id: 113653:GAH_RS01835
uniprot id: A0A0F7IH68
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

113653:GAH RS05115
gene id: 113653:GAH_RS05115
uniprot id: A0A0F7IFJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

113653:GAH RS04050
gene id: 113653:GAH_RS04050
uniprot id: A0A0F7IG63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

113653:GAH RS00595
gene id: 113653:GAH_RS00595
uniprot id: A0A0F7IJW2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

113653:GAH RS09555
gene id: 113653:GAH_RS09555
uniprot id: A0A0F7IC50
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

113653:GAH RS08340
gene id: 113653:GAH_RS08340
uniprot id: A0A0F7DBG1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

113653:GAH RS02680
gene id: 113653:GAH_RS02680
uniprot id: A0A0F7IEU1
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

113653:GAH RS09265
gene id: 113653:GAH_RS09265
uniprot id: A0A0F7IG61
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

113653:GAH RS10195
gene id: 113653:GAH_RS10195
uniprot id: A0A0F7IFS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

113653:GAH RS02060
gene id: 113653:GAH_RS02060
uniprot id: A0A0F7IG94
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

113653:GAH RS09400
gene id: 113653:GAH_RS09400
uniprot id: A0A0F7IEK3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

113653:GAH RS04385
gene id: 113653:GAH_RS04385
uniprot id: A0A0F7IIG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

113653:GAH RS08990
gene id: 113653:GAH_RS08990
uniprot id: A0A0F7IES1
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS08315
gene id: 113653:GAH_RS08315
uniprot id: A0A0F7DBG2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS05555
gene id: 113653:GAH_RS05555
uniprot id: A0A0F7DBR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

113653:GAH RS08685
gene id: 113653:GAH_RS08685
uniprot id: A0A0F7IE59
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

113653:GAH RS09840
gene id: 113653:GAH_RS09840
uniprot id: A0A0F7IC04
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS02985
gene id: 113653:GAH_RS02985
uniprot id: A0A0F7IIT2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

113653:GAH RS00625
gene id: 113653:GAH_RS00625
uniprot id: A0A0F7II79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

113653:GAH RS10130
gene id: 113653:GAH_RS10130
uniprot id: A0A0F7IFS4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

113653:GAH RS07295
gene id: 113653:GAH_RS07295
uniprot id: A0A0F7IE65
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

113653:GAH RS01710
gene id: 113653:GAH_RS01710
uniprot id: A0A0F7IHT0
names: Similarity
messages: Belongs to the complex I subunit 3 family.

113653:GAH RS06415
gene id: 113653:GAH_RS06415
uniprot id: A0A0F7IHA4
names: Similarity
messages: Belongs to the FTR family.

113653:GAH RS06640
gene id: 113653:GAH_RS06640
uniprot id: A0A0F7DBM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

113653:GAH RS01805
gene id: 113653:GAH_RS01805
uniprot id: A0A0F7IH76
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

113653:GAH RS01345
gene id: 113653:GAH_RS01345
uniprot id: A0A0F7IFQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

113653:GAH RS00305
gene id: 113653:GAH_RS00305
uniprot id: A0A0F7IGA7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS08035
gene id: 113653:GAH_RS08035
uniprot id: A0A0F7IGK9
names: Similarity
messages: Belongs to the UbiD family.

113653:GAH RS05000
gene id: 113653:GAH_RS05000
uniprot id: A0A0F7IDU2
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

113653:GAH RS04700
gene id: 113653:GAH_RS04700
uniprot id: A0A0F7DBV0
names: Similarity
messages: Belongs to the AAA ATPase family.

113653:GAH RS05685
gene id: 113653:GAH_RS05685
uniprot id: A0A0F7DBR2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS03420
gene id: 113653:GAH_RS03420
uniprot id: A0A0F7IH04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

113653:GAH RS06895
gene id: 113653:GAH_RS06895
uniprot id: A0A0F7DBL7
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

113653:GAH RS06305
gene id: 113653:GAH_RS06305
uniprot id: A0A0F7IF97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

113653:GAH RS07780
gene id: 113653:GAH_RS07780
uniprot id: A0A0F7ICY7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS01375
gene id: 113653:GAH_RS01375
uniprot id: A0A0F7DC79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

113653:GAH RS09530
gene id: 113653:GAH_RS09530
uniprot id: A0A0F7IFY4
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

113653:GAH RS03920
gene id: 113653:GAH_RS03920
uniprot id: A0A0F7IGA1
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS03245
gene id: 113653:GAH_RS03245
uniprot id: A0A0F7DC06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

113653:GAH RS00440
gene id: 113653:GAH_RS00440
uniprot id: A0A0F7II98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

113653:GAH RS06965
gene id: 113653:GAH_RS06965
uniprot id: A0A0F7IEB3
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

113653:GAH RS08555
gene id: 113653:GAH_RS08555
uniprot id: A0A0F7IDJ4
names: Similarity
messages: Belongs to the AOR/FOR family.

113653:GAH RS05780
gene id: 113653:GAH_RS05780
uniprot id: A0A0F7IDJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

113653:GAH RS02600
gene id: 113653:GAH_RS02600
uniprot id: A0A0F7IGY0
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

113653:GAH RS00480
gene id: 113653:GAH_RS00480
uniprot id: A0A0F7IGY4
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

113653:GAH RS09845
gene id: 113653:GAH_RS09845
uniprot id: A0A0F7IFU9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

113653:GAH RS00725
gene id: 113653:GAH_RS00725
uniprot id: A0A0F7IHQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

113653:GAH RS06925
gene id: 113653:GAH_RS06925
uniprot id: A0A0F7IFL6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

113653:GAH RS02455
gene id: 113653:GAH_RS02455
uniprot id: A0A0F7IIZ4
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

113653:GAH RS03000
gene id: 113653:GAH_RS03000
uniprot id: A0A0F7IGP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

113653:GAH RS09820
gene id: 113653:GAH_RS09820
uniprot id: A0A0F7IEE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

113653:GAH RS04055
gene id: 113653:GAH_RS04055
uniprot id: A0A0F7IFE7
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

113653:GAH RS06980
gene id: 113653:GAH_RS06980
uniprot id: A0A0F7IH38
names: Subcellular Location Annotation
messages: Membrane

113653:GAH RS00795
gene id: 113653:GAH_RS00795
uniprot id: A0A0F7IGU1
names: Subcellular Location Annotation
messages: Cell membrane

113653:GAH RS02920
gene id: 113653:GAH_RS02920
uniprot id: A0A0F7IGQ4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

113653:GAH RS08030
gene id: 113653:GAH_RS08030
uniprot id: A0A0F7ICR6
names: Function
names: Similarity
messages: Belongs to the UPF0330 family.
messages: Possibly the antitoxin component of a toxin-antitoxin (TA) module.

113653:GAH RS04460
gene id: 113653:GAH_RS04460
uniprot id: A0A0F7IFZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

113653:GAH RS11070
gene id: 113653:GAH_RS11070
uniprot id: A0A0F7IDN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

113653:GAH RS06710
gene id: 113653:GAH_RS06710
uniprot id: A0A0F7IF44
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS06320
gene id: 113653:GAH_RS06320
uniprot id: A0A0F7IHB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

113653:GAH RS05155
gene id: 113653:GAH_RS05155
uniprot id: A0A0F7IF25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

113653:GAH RS07300
gene id: 113653:GAH_RS07300
uniprot id: A0A0F7ID49
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

113653:GAH RS01390
gene id: 113653:GAH_RS01390
uniprot id: A0A0F7IHY4
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

113653:GAH RS03175
gene id: 113653:GAH_RS03175
uniprot id: A0A0F7IEM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane