1122984:BWX39 RS03790
gene id: 1122984:BWX39_RS03790
uniprot id: A0A1P8JDM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Membrane

1122984:BWX39 RS09695
gene id: 1122984:BWX39_RS09695
uniprot id: A0A1P8JGW3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1122984:BWX39 RS04340
gene id: 1122984:BWX39_RS04340
uniprot id: A0A1P8JDX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

1122984:BWX39 RS04590
gene id: 1122984:BWX39_RS04590
uniprot id: A0A1P8JE22
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

1122984:BWX39 RS06740
gene id: 1122984:BWX39_RS06740
uniprot id: A0A1P8JF15
names: Similarity
messages: Belongs to the XseB family.

1122984:BWX39 RS02605
gene id: 1122984:BWX39_RS02605
uniprot id: A0A1P8JCZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane

1122984:BWX39 RS08310
gene id: 1122984:BWX39_RS08310
uniprot id: A0A1P8JFV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1122984:BWX39 RS02270
gene id: 1122984:BWX39_RS02270
uniprot id: A0A1P8JCV0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1122984:BWX39 RS09760
gene id: 1122984:BWX39_RS09760
uniprot id: A0A1P8JGU7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

1122984:BWX39 RS05705
gene id: 1122984:BWX39_RS05705
uniprot id: A0A1P8JEL2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1122984:BWX39 RS01215
gene id: 1122984:BWX39_RS01215
uniprot id: A0A1P8JCA1
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1122984:BWX39 RS10570
gene id: 1122984:BWX39_RS10570
uniprot id: A0A1P8JHA0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1122984:BWX39 RS00250
gene id: 1122984:BWX39_RS00250
uniprot id: A0A1P8JBT6
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

1122984:BWX39 RS06025
gene id: 1122984:BWX39_RS06025
uniprot id: A0A1P8JEQ9
names: Similarity
messages: Belongs to the peptidase C1 family.

1122984:BWX39 RS07875
gene id: 1122984:BWX39_RS07875
uniprot id: A0A1P8JFL9
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

1122984:BWX39 RS05365
gene id: 1122984:BWX39_RS05365
uniprot id: A0A1P8JEC5
names: Similarity
messages: Belongs to the AIR synthase family.

1122984:BWX39 RS03240
gene id: 1122984:BWX39_RS03240
uniprot id: A0A1P8JDD7
names: Similarity
messages: Belongs to the peptidase S8 family.

1122984:BWX39 RS07235
gene id: 1122984:BWX39_RS07235
uniprot id: A0A1P8JFC0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

1122984:BWX39 RS04335
gene id: 1122984:BWX39_RS04335
uniprot id: A0A1P8JDW3
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

1122984:BWX39 RS08000
gene id: 1122984:BWX39_RS08000
uniprot id: A0A1P8JFP8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1122984:BWX39 RS08235
gene id: 1122984:BWX39_RS08235
uniprot id: A0A1P8JFT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1122984:BWX39 RS04755
gene id: 1122984:BWX39_RS04755
uniprot id: A0A1P8JE40
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1122984:BWX39 RS05885
gene id: 1122984:BWX39_RS05885
uniprot id: A0A1P8JEN1
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

1122984:BWX39 RS04135
gene id: 1122984:BWX39_RS04135
uniprot id: A0A1P8JDR5
names: Function
names: Similarity
messages: A P subtype restriction enzyme that recognizes the double-stranded unmethylated sequence 5'-GATC-3'.
messages: Belongs to the DpnII type II restriction endonuclease family.

1122984:BWX39 RS03765
gene id: 1122984:BWX39_RS03765
uniprot id: A0A1P8JDJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

1122984:BWX39 RS02495
gene id: 1122984:BWX39_RS02495
uniprot id: A0A1P8JCZ3
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1122984:BWX39 RS08880
gene id: 1122984:BWX39_RS08880
uniprot id: A0A1P8JGG7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1122984:BWX39 RS01940
gene id: 1122984:BWX39_RS01940
uniprot id: A0A1P8JCP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1122984:BWX39 RS07240
gene id: 1122984:BWX39_RS07240
uniprot id: A0A1P8JFB8
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1122984:BWX39 RS01025
gene id: 1122984:BWX39_RS01025
uniprot id: A0A1P8JCA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

1122984:BWX39 RS03800
gene id: 1122984:BWX39_RS03800
uniprot id: A0A1P8JDL4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1122984:BWX39 RS03850
gene id: 1122984:BWX39_RS03850
uniprot id: A0A1P8JDN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1122984:BWX39 RS08380
gene id: 1122984:BWX39_RS08380
uniprot id: A0A1P8JFY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1122984:BWX39 RS10200
gene id: 1122984:BWX39_RS10200
uniprot id: A0A1P8JH29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

1122984:BWX39 RS00620
gene id: 1122984:BWX39_RS00620
uniprot id: A0A1P8JC00
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS04130
gene id: 1122984:BWX39_RS04130
uniprot id: A0A1P8JDS8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1122984:BWX39 RS04935
gene id: 1122984:BWX39_RS04935
uniprot id: A0A1P8JE58
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1122984:BWX39 RS03310
gene id: 1122984:BWX39_RS03310
uniprot id: A0A1P8JDC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

1122984:BWX39 RS00880
gene id: 1122984:BWX39_RS00880
uniprot id: A0A1P8JC50
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

1122984:BWX39 RS03955
gene id: 1122984:BWX39_RS03955
uniprot id: A0A1P8JDN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
messages: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
messages: Cytoplasm
messages: Homodimer.

1122984:BWX39 RS05395
gene id: 1122984:BWX39_RS05395
uniprot id: A0A1P8JEE9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1122984:BWX39 RS01465
gene id: 1122984:BWX39_RS01465
uniprot id: A0A1P8JCI8
names: Similarity
messages: Belongs to the DprA/Smf family.

1122984:BWX39 RS03340
gene id: 1122984:BWX39_RS03340
uniprot id: A0A1P8JDC9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1122984:BWX39 RS06185
gene id: 1122984:BWX39_RS06185
uniprot id: A0A1P8JER7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS08060
gene id: 1122984:BWX39_RS08060
uniprot id: A0A1P8JFR5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1122984:BWX39 RS07690
gene id: 1122984:BWX39_RS07690
uniprot id: A0A1P8JFJ4
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

1122984:BWX39 RS00120
gene id: 1122984:BWX39_RS00120
uniprot id: A0A1P8JFY7
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

1122984:BWX39 RS10485
gene id: 1122984:BWX39_RS10485
uniprot id: A0A1P8JH94
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

1122984:BWX39 RS08090
gene id: 1122984:BWX39_RS08090
uniprot id: A0A1P8JFQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1122984:BWX39 RS07200
gene id: 1122984:BWX39_RS07200
uniprot id: A0A1P8JFC1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1122984:BWX39 RS01590
gene id: 1122984:BWX39_RS01590
uniprot id: A0A1P8JCH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1122984:BWX39 RS04305
gene id: 1122984:BWX39_RS04305
uniprot id: A0A1P8JDV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.
messages: Golgi apparatus
messages: Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.
messages: In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.
messages: In the N-terminal section; belongs to the formiminotransferase family.
messages: centriole

1122984:BWX39 RS05890
gene id: 1122984:BWX39_RS05890
uniprot id: A0A1P8JEL6
names: Similarity
messages: Belongs to the UPF0246 family.

1122984:BWX39 RS01030
gene id: 1122984:BWX39_RS01030
uniprot id: A0A1P8JC72
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1122984:BWX39 RS07975
gene id: 1122984:BWX39_RS07975
uniprot id: A0A1P8JGB1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1122984:BWX39 RS09700
gene id: 1122984:BWX39_RS09700
uniprot id: A0A1P8JGT8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1122984:BWX39 RS05755
gene id: 1122984:BWX39_RS05755
uniprot id: A0A1P8JEK9
names: Similarity
messages: Belongs to the FemABX family.

1122984:BWX39 RS05680
gene id: 1122984:BWX39_RS05680
uniprot id: A0A1P8JEJ2
names: Similarity
messages: Belongs to the peptidase M13 family.

1122984:BWX39 RS00730
gene id: 1122984:BWX39_RS00730
uniprot id: A0A1P8JC19
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS04820
gene id: 1122984:BWX39_RS04820
uniprot id: A0A1P8JE37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

1122984:BWX39 RS06435
gene id: 1122984:BWX39_RS06435
uniprot id: A0A1P8JEW3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1122984:BWX39 RS11690
gene id: 1122984:BWX39_RS11690
uniprot id: A0A1P8JGE3
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS01395
gene id: 1122984:BWX39_RS01395
uniprot id: A0A1P8JCD8
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS09970
gene id: 1122984:BWX39_RS09970
uniprot id: A0A1P8JH12
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1122984:BWX39 RS03065
gene id: 1122984:BWX39_RS03065
uniprot id: A0A1P8JD88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1122984:BWX39 RS01890
gene id: 1122984:BWX39_RS01890
uniprot id: A0A1P8JCM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1122984:BWX39 RS05055
gene id: 1122984:BWX39_RS05055
uniprot id: A0A1P8JE84
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS03345
gene id: 1122984:BWX39_RS03345
uniprot id: A0A1P8JDF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

1122984:BWX39 RS06420
gene id: 1122984:BWX39_RS06420
uniprot id: A0A1P8JEW7
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1122984:BWX39 RS10310
gene id: 1122984:BWX39_RS10310
uniprot id: A0A1P8JH51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methylaspartate mutase GlmE subunit family.
messages: Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
messages: Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.

1122984:BWX39 RS03710
gene id: 1122984:BWX39_RS03710
uniprot id: A0A1P8JDI8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1122984:BWX39 RS03670
gene id: 1122984:BWX39_RS03670
uniprot id: A0A1P8JDJ3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

1122984:BWX39 RS02135
gene id: 1122984:BWX39_RS02135
uniprot id: A0A1P8JCQ4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1122984:BWX39 RS07485
gene id: 1122984:BWX39_RS07485
uniprot id: A0A1P8JFH4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

1122984:BWX39 RS10175
gene id: 1122984:BWX39_RS10175
uniprot id: A0A1P8JH26
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS05740
gene id: 1122984:BWX39_RS05740
uniprot id: A0A1P8JEK1
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1122984:BWX39 RS08440
gene id: 1122984:BWX39_RS08440
uniprot id: A0A1P8JFX5
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1122984:BWX39 RS07180
gene id: 1122984:BWX39_RS07180
uniprot id: A0A1P8JFB5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS04025
gene id: 1122984:BWX39_RS04025
uniprot id: A0A1P8JDT0
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

1122984:BWX39 RS05655
gene id: 1122984:BWX39_RS05655
uniprot id: A0A1P8JEK6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1122984:BWX39 RS01910
gene id: 1122984:BWX39_RS01910
uniprot id: A0A1P8JCL9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1122984:BWX39 RS02660
gene id: 1122984:BWX39_RS02660
uniprot id: A0A1P8JD07
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS00790
gene id: 1122984:BWX39_RS00790
uniprot id: A0A1P8JC26
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

1122984:BWX39 RS10215
gene id: 1122984:BWX39_RS10215
uniprot id: A0A1P8JHV3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1122984:BWX39 RS03570
gene id: 1122984:BWX39_RS03570
uniprot id: A0A1P8JDH2
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS02280
gene id: 1122984:BWX39_RS02280
uniprot id: A0A1P8JCW1
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1122984:BWX39 RS10355
gene id: 1122984:BWX39_RS10355
uniprot id: A0A1P8JH73
names: Function
names: Similarity
messages: Belongs to the peptidase S46 family.
messages: Catalyzes the removal of dipeptides from the N-terminus of oligopeptides.

1122984:BWX39 RS01560
gene id: 1122984:BWX39_RS01560
uniprot id: A0A1P8JCG8
names: Similarity
messages: Belongs to the DapB family.

1122984:BWX39 RS08210
gene id: 1122984:BWX39_RS08210
uniprot id: A0A1P8JFW0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1122984:BWX39 RS00940
gene id: 1122984:BWX39_RS00940
uniprot id: A0A1P8JC64
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

1122984:BWX39 RS03835
gene id: 1122984:BWX39_RS03835
uniprot id: A0A1P8JG52
names: Similarity
messages: Belongs to the Dps family.

1122984:BWX39 RS02065
gene id: 1122984:BWX39_RS02065
uniprot id: A0A1P8JCS0
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1122984:BWX39 RS03660
gene id: 1122984:BWX39_RS03660
uniprot id: A0A1P8JDJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1122984:BWX39 RS06530
gene id: 1122984:BWX39_RS06530
uniprot id: A0A1P8JEY1
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

1122984:BWX39 RS10275
gene id: 1122984:BWX39_RS10275
uniprot id: A0A1P8JH49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1122984:BWX39 RS04930
gene id: 1122984:BWX39_RS04930
uniprot id: A0A1P8JE80
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1122984:BWX39 RS03075
gene id: 1122984:BWX39_RS03075
uniprot id: A0A1P8JD74
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

1122984:BWX39 RS00095
gene id: 1122984:BWX39_RS00095
uniprot id: A0A1P8JFY8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

1122984:BWX39 RS04020
gene id: 1122984:BWX39_RS04020
uniprot id: A0A1P8JDS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

1122984:BWX39 RS04145
gene id: 1122984:BWX39_RS04145
uniprot id: A0A1P8JDS2
names: Similarity
messages: Belongs to the peptidase S8 family.

1122984:BWX39 RS08375
gene id: 1122984:BWX39_RS08375
uniprot id: A0A1P8JFV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1122984:BWX39 RS07710
gene id: 1122984:BWX39_RS07710
uniprot id: A0A1P8JFL7
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

1122984:BWX39 RS05065
gene id: 1122984:BWX39_RS05065
uniprot id: A0A1P8JE97
names: Similarity
messages: Belongs to the type IA topoisomerase family.

1122984:BWX39 RS02035
gene id: 1122984:BWX39_RS02035
uniprot id: A0A1P8JCP3
names: Similarity
messages: Belongs to the peptidase C10 family.

1122984:BWX39 RS06275
gene id: 1122984:BWX39_RS06275
uniprot id: A0A1P8JEU9
names: Similarity
messages: Belongs to the cytochrome c-552 family.

1122984:BWX39 RS08305
gene id: 1122984:BWX39_RS08305
uniprot id: A0A1P8JGC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1122984:BWX39 RS00990
gene id: 1122984:BWX39_RS00990
uniprot id: A0A1P8JC69
names: Similarity
messages: Belongs to the UPF0597 family.

1122984:BWX39 RS01935
gene id: 1122984:BWX39_RS01935
uniprot id: A0A1P8JCT1
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS06635
gene id: 1122984:BWX39_RS06635
uniprot id: A0A1P8JF07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-ACP thioesterase family.
messages: chloroplast

1122984:BWX39 RS00295
gene id: 1122984:BWX39_RS00295
uniprot id: A0A1P8JBU6
names: Similarity
messages: Belongs to the LOG family.

1122984:BWX39 RS09010
gene id: 1122984:BWX39_RS09010
uniprot id: A0A1P8JGJ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1122984:BWX39 RS09885
gene id: 1122984:BWX39_RS09885
uniprot id: A0A1P8JGY1
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1122984:BWX39 RS06465
gene id: 1122984:BWX39_RS06465
uniprot id: A0A1P8JEY4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CutC family.
messages: Cytoplasm
messages: Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.

1122984:BWX39 RS07530
gene id: 1122984:BWX39_RS07530
uniprot id: A0A1P8JFG4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides.
messages: Cytoplasm

1122984:BWX39 RS00500
gene id: 1122984:BWX39_RS00500
uniprot id: A0A1P8JBY0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1122984:BWX39 RS06595
gene id: 1122984:BWX39_RS06595
uniprot id: A0A1P8JEZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1122984:BWX39 RS08350
gene id: 1122984:BWX39_RS08350
uniprot id: A0A1P8JFY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1122984:BWX39 RS02125
gene id: 1122984:BWX39_RS02125
uniprot id: A0A1P8JCR6
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

1122984:BWX39 RS01325
gene id: 1122984:BWX39_RS01325
uniprot id: A0A1P8JCC2
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

1122984:BWX39 RS08025
gene id: 1122984:BWX39_RS08025
uniprot id: A0A1P8JFR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1122984:BWX39 RS04710
gene id: 1122984:BWX39_RS04710
uniprot id: A0A1P8JE44
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1122984:BWX39 RS09775
gene id: 1122984:BWX39_RS09775
uniprot id: A0A1P8JGX1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1122984:BWX39 RS03350
gene id: 1122984:BWX39_RS03350
uniprot id: A0A1P8JDF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1122984:BWX39 RS04680
gene id: 1122984:BWX39_RS04680
uniprot id: A0A1P8JE29
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1122984:BWX39 RS04870
gene id: 1122984:BWX39_RS04870
uniprot id: A0A1P8JE73
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS04190
gene id: 1122984:BWX39_RS04190
uniprot id: A0A1P8JDT2
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS02730
gene id: 1122984:BWX39_RS02730
uniprot id: A0A1P8JD23
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1122984:BWX39 RS01830
gene id: 1122984:BWX39_RS01830
uniprot id: A0A1P8JCL2
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1122984:BWX39 RS07985
gene id: 1122984:BWX39_RS07985
uniprot id: A0A1P8JFP0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

1122984:BWX39 RS04910
gene id: 1122984:BWX39_RS04910
uniprot id: A0A1P8JE70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1122984:BWX39 RS03485
gene id: 1122984:BWX39_RS03485
uniprot id: A0A1P8JDG6
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS01960
gene id: 1122984:BWX39_RS01960
uniprot id: A0A1P8JCR1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1122984:BWX39 RS02755
gene id: 1122984:BWX39_RS02755
uniprot id: A0A1P8JG50
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1122984:BWX39 RS07145
gene id: 1122984:BWX39_RS07145
uniprot id: A0A1P8JF89
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1122984:BWX39 RS01845
gene id: 1122984:BWX39_RS01845
uniprot id: A0A1P8JCL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1122984:BWX39 RS05040
gene id: 1122984:BWX39_RS05040
uniprot id: A0A1P8JEA6
names: Similarity
messages: Belongs to the FBPase class 3 family.

1122984:BWX39 RS01505
gene id: 1122984:BWX39_RS01505
uniprot id: A0A1P8JCF5
names: Similarity
messages: Belongs to the peptidase S41A family.

1122984:BWX39 RS00515
gene id: 1122984:BWX39_RS00515
uniprot id: A0A1P8JBX9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

1122984:BWX39 RS01445
gene id: 1122984:BWX39_RS01445
uniprot id: A0A1P8JG35
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

1122984:BWX39 RS07705
gene id: 1122984:BWX39_RS07705
uniprot id: A0A1P8JFJ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS05345
gene id: 1122984:BWX39_RS05345
uniprot id: A0A1P8JED8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

1122984:BWX39 RS05330
gene id: 1122984:BWX39_RS05330
uniprot id: A0A1P8JED9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1122984:BWX39 RS05025
gene id: 1122984:BWX39_RS05025
uniprot id: A0A1P8JE89
names: Similarity
messages: Belongs to the aspartokinase family.

1122984:BWX39 RS10145
gene id: 1122984:BWX39_RS10145
uniprot id: A0A1P8JH15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

1122984:BWX39 RS10425
gene id: 1122984:BWX39_RS10425
uniprot id: A0A1P8JH91
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrC family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1122984:BWX39 RS04555
gene id: 1122984:BWX39_RS04555
uniprot id: A0A1P8JDZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1122984:BWX39 RS06460
gene id: 1122984:BWX39_RS06460
uniprot id: A0A1P8JEW2
names: Function
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

1122984:BWX39 RS10795
gene id: 1122984:BWX39_RS10795
uniprot id: A0A1P8JHF8
names: Similarity
messages: Belongs to the glutathione peroxidase family.

1122984:BWX39 RS03750
gene id: 1122984:BWX39_RS03750
uniprot id: A0A1P8JDK1
names: Similarity
messages: Belongs to the thioredoxin family.

1122984:BWX39 RS04360
gene id: 1122984:BWX39_RS04360
uniprot id: A0A1P8JDW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1122984:BWX39 RS09530
gene id: 1122984:BWX39_RS09530
uniprot id: A0A1P8JGS9
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

1122984:BWX39 RS06175
gene id: 1122984:BWX39_RS06175
uniprot id: A0A1P8JEU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).

1122984:BWX39 RS06440
gene id: 1122984:BWX39_RS06440
uniprot id: A0A1P8JEX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1122984:BWX39 RS10775
gene id: 1122984:BWX39_RS10775
uniprot id: A0A1P8JHZ1
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

1122984:BWX39 RS09710
gene id: 1122984:BWX39_RS09710
uniprot id: A0A1P8JGW1
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1122984:BWX39 RS02645
gene id: 1122984:BWX39_RS02645
uniprot id: A0A1P8JD24
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

1122984:BWX39 RS00720
gene id: 1122984:BWX39_RS00720
uniprot id: A0A1P8JC14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

1122984:BWX39 RS05575
gene id: 1122984:BWX39_RS05575
uniprot id: A0A1P8JEH2
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS00800
gene id: 1122984:BWX39_RS00800
uniprot id: A0A1P8JC70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

1122984:BWX39 RS10205
gene id: 1122984:BWX39_RS10205
uniprot id: A0A1P8JH46
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

1122984:BWX39 RS09575
gene id: 1122984:BWX39_RS09575
uniprot id: A0A1P8JGS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1122984:BWX39 RS01485
gene id: 1122984:BWX39_RS01485
uniprot id: A0A1P8JCF7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M15D family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.

1122984:BWX39 RS01055
gene id: 1122984:BWX39_RS01055
uniprot id: A0A1P8JC82
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1122984:BWX39 RS08295
gene id: 1122984:BWX39_RS08295
uniprot id: A0A1P8JFX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1122984:BWX39 RS02830
gene id: 1122984:BWX39_RS02830
uniprot id: A0A1P8JD44
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS02300
gene id: 1122984:BWX39_RS02300
uniprot id: A0A1P8JCU0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1122984:BWX39 RS11385
gene id: 1122984:BWX39_RS11385
uniprot id: A0A1P8JHP5
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS06010
gene id: 1122984:BWX39_RS06010
uniprot id: A0A1P8JER6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1122984:BWX39 RS07800
gene id: 1122984:BWX39_RS07800
uniprot id: A0A1P8JFM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

1122984:BWX39 RS08215
gene id: 1122984:BWX39_RS08215
uniprot id: A0A1P8JFT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell membrane
messages: Membrane

1122984:BWX39 RS07080
gene id: 1122984:BWX39_RS07080
uniprot id: A0A1P8JF85
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS06035
gene id: 1122984:BWX39_RS06035
uniprot id: A0A1P8JEQ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS07525
gene id: 1122984:BWX39_RS07525
uniprot id: A0A1P8JGC4
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1122984:BWX39 RS04290
gene id: 1122984:BWX39_RS04290
uniprot id: A0A1P8JDW0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

1122984:BWX39 RS03120
gene id: 1122984:BWX39_RS03120
uniprot id: A0A1P8JDA2
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1122984:BWX39 RS11055
gene id: 1122984:BWX39_RS11055
uniprot id: A0A1P8JHI6
names: Similarity
messages: Belongs to the type IA topoisomerase family.

1122984:BWX39 RS00650
gene id: 1122984:BWX39_RS00650
uniprot id: A0A1P8JC37
names: Similarity
messages: Belongs to the peptidase C69 family.

1122984:BWX39 RS00690
gene id: 1122984:BWX39_RS00690
uniprot id: A0A1P8JC09
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1122984:BWX39 RS09170
gene id: 1122984:BWX39_RS09170
uniprot id: A0A1P8JGN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

1122984:BWX39 RS06590
gene id: 1122984:BWX39_RS06590
uniprot id: A0A1P8JG92
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1122984:BWX39 RS06555
gene id: 1122984:BWX39_RS06555
uniprot id: A0A1P8JEZ4
names: Similarity
messages: Belongs to the beta-eliminating lyase family.

1122984:BWX39 RS00610
gene id: 1122984:BWX39_RS00610
uniprot id: A0A1P8JBZ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1122984:BWX39 RS06480
gene id: 1122984:BWX39_RS06480
uniprot id: A0A1P8JEX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

1122984:BWX39 RS03735
gene id: 1122984:BWX39_RS03735
uniprot id: A0A1P8JDK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1122984:BWX39 RS10420
gene id: 1122984:BWX39_RS10420
uniprot id: A0A1P8JH83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1122984:BWX39 RS02240
gene id: 1122984:BWX39_RS02240
uniprot id: A0A1P8JCT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1122984:BWX39 RS03150
gene id: 1122984:BWX39_RS03150
uniprot id: A0A1P8JD99
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1122984:BWX39 RS05835
gene id: 1122984:BWX39_RS05835
uniprot id: A0A1P8JEK8
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS01785
gene id: 1122984:BWX39_RS01785
uniprot id: A0A1P8JCK7
names: Caution
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS04195
gene id: 1122984:BWX39_RS04195
uniprot id: A0A1P8JDS5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1122984:BWX39 RS04125
gene id: 1122984:BWX39_RS04125
uniprot id: A0A1P8JDS0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

1122984:BWX39 RS07820
gene id: 1122984:BWX39_RS07820
uniprot id: A0A1P8JFL6
names: Similarity
messages: Belongs to the isochorismate synthase family.

1122984:BWX39 RS00480
gene id: 1122984:BWX39_RS00480
uniprot id: A0A1P8JBX2
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

1122984:BWX39 RS01895
gene id: 1122984:BWX39_RS01895
uniprot id: A0A1P8JCP4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1122984:BWX39 RS08490
gene id: 1122984:BWX39_RS08490
uniprot id: A0A1P8JFX6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1122984:BWX39 RS06790
gene id: 1122984:BWX39_RS06790
uniprot id: A0A1P8JF23
names: Similarity
messages: Belongs to the CarB family.

1122984:BWX39 RS07570
gene id: 1122984:BWX39_RS07570
uniprot id: A0A1P8JFH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAE transporter (TC 2.A.81) family.
messages: Cell membrane
messages: Membrane

1122984:BWX39 RS10110
gene id: 1122984:BWX39_RS10110
uniprot id: A0A1P8JH17
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1122984:BWX39 RS04300
gene id: 1122984:BWX39_RS04300
uniprot id: A0A1P8JDV9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS03480
gene id: 1122984:BWX39_RS03480
uniprot id: A0A1P8JDF4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1122984:BWX39 RS04060
gene id: 1122984:BWX39_RS04060
uniprot id: A0A1P8JDR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1122984:BWX39 RS05045
gene id: 1122984:BWX39_RS05045
uniprot id: A0A1P8JE77
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

1122984:BWX39 RS04530
gene id: 1122984:BWX39_RS04530
uniprot id: A0A1P8JDZ9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1122984:BWX39 RS04625
gene id: 1122984:BWX39_RS04625
uniprot id: A0A1P8JE20
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1122984:BWX39 RS04905
gene id: 1122984:BWX39_RS04905
uniprot id: A0A1P8JE52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1122984:BWX39 RS04210
gene id: 1122984:BWX39_RS04210
uniprot id: A0A1P8JDV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

1122984:BWX39 RS06860
gene id: 1122984:BWX39_RS06860
uniprot id: A0A1P8JF57
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

1122984:BWX39 RS00665
gene id: 1122984:BWX39_RS00665
uniprot id: A0A1P8JC02
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1122984:BWX39 RS06745
gene id: 1122984:BWX39_RS06745
uniprot id: A0A1P8JF41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XseA family.
messages: Cytoplasm

1122984:BWX39 RS07140
gene id: 1122984:BWX39_RS07140
uniprot id: A0A1P8JF88
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS00425
gene id: 1122984:BWX39_RS00425
uniprot id: A0A1P8JBW3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.

1122984:BWX39 RS03125
gene id: 1122984:BWX39_RS03125
uniprot id: A0A1P8JD91
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1122984:BWX39 RS09955
gene id: 1122984:BWX39_RS09955
uniprot id: A0A1P8JH05
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1122984:BWX39 RS00050
gene id: 1122984:BWX39_RS00050
uniprot id: A0A1P8JFX6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1122984:BWX39 RS07825
gene id: 1122984:BWX39_RS07825
uniprot id: A0A1P8JFL1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

1122984:BWX39 RS08500
gene id: 1122984:BWX39_RS08500
uniprot id: A0A1P8JGC0
names: Similarity
messages: Belongs to the peptidase M24B family.

1122984:BWX39 RS00380
gene id: 1122984:BWX39_RS00380
uniprot id: A0A1P8JBW0
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

1122984:BWX39 RS01410
gene id: 1122984:BWX39_RS01410
uniprot id: A0A1P8JCH6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1122984:BWX39 RS00685
gene id: 1122984:BWX39_RS00685
uniprot id: A0A1P8JC06
names: Similarity
messages: Belongs to the Skp family.

1122984:BWX39 RS09705
gene id: 1122984:BWX39_RS09705
uniprot id: A0A1P8JGV0
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

1122984:BWX39 RS04705
gene id: 1122984:BWX39_RS04705
uniprot id: A0A1P8JE30
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

1122984:BWX39 RS09495
gene id: 1122984:BWX39_RS09495
uniprot id: A0A1P8JGS3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1122984:BWX39 RS04085
gene id: 1122984:BWX39_RS04085
uniprot id: A0A1P8JDU0
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS03465
gene id: 1122984:BWX39_RS03465
uniprot id: A0A1P8JDH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1122984:BWX39 RS08505
gene id: 1122984:BWX39_RS08505
uniprot id: A0A1P8JBP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S41B family.
messages: Cytoplasm
messages: Degrades oligopeptides.

1122984:BWX39 RS09855
gene id: 1122984:BWX39_RS09855
uniprot id: A0A1P8JGX2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1122984:BWX39 RS07640
gene id: 1122984:BWX39_RS07640
uniprot id: A0A1P8JFI3
names: Similarity
messages: Belongs to the HSP15 family.

1122984:BWX39 RS01225
gene id: 1122984:BWX39_RS01225
uniprot id: A0A1P8JCA9
names: Similarity
messages: Belongs to the sigma-54 factor family.

1122984:BWX39 RS08820
gene id: 1122984:BWX39_RS08820
uniprot id: A0A1P8JGF6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1122984:BWX39 RS04175
gene id: 1122984:BWX39_RS04175
uniprot id: A0A1P8JG54
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1122984:BWX39 RS02540
gene id: 1122984:BWX39_RS02540
uniprot id: A0A1P8JCZ0
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS06940
gene id: 1122984:BWX39_RS06940
uniprot id: A0A1P8JF71
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1122984:BWX39 RS06845
gene id: 1122984:BWX39_RS06845
uniprot id: A0A1P8JF79
names: Cofactor
names: Similarity
messages: Belongs to the ApbE family.
messages: Magnesium. Can also use manganese.

1122984:BWX39 RS02925
gene id: 1122984:BWX39_RS02925
uniprot id: A0A1P8JD70
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1122984:BWX39 RS04670
gene id: 1122984:BWX39_RS04670
uniprot id: A0A1P8JE16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

1122984:BWX39 RS06880
gene id: 1122984:BWX39_RS06880
uniprot id: A0A1P8JGB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1122984:BWX39 RS09745
gene id: 1122984:BWX39_RS09745
uniprot id: A0A1P8JHW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Membrane

1122984:BWX39 RS01780
gene id: 1122984:BWX39_RS01780
uniprot id: A0A1P8JCK6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1122984:BWX39 RS03460
gene id: 1122984:BWX39_RS03460
uniprot id: A0A1P8JDH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1122984:BWX39 RS07030
gene id: 1122984:BWX39_RS07030
uniprot id: A0A1P8JF67
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS06005
gene id: 1122984:BWX39_RS06005
uniprot id: A0A1P8JEN9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1122984:BWX39 RS08750
gene id: 1122984:BWX39_RS08750
uniprot id: A0A1P8JGE9
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1122984:BWX39 RS06870
gene id: 1122984:BWX39_RS06870
uniprot id: A0A1P8JF33
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1122984:BWX39 RS10245
gene id: 1122984:BWX39_RS10245
uniprot id: A0A1P8JH40
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS10170
gene id: 1122984:BWX39_RS10170
uniprot id: A0A1P8JH27
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS07645
gene id: 1122984:BWX39_RS07645
uniprot id: A0A1P8JFJ7
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS08865
gene id: 1122984:BWX39_RS08865
uniprot id: A0A1P8JGG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

1122984:BWX39 RS07995
gene id: 1122984:BWX39_RS07995
uniprot id: A0A1P8JFR3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

1122984:BWX39 RS09730
gene id: 1122984:BWX39_RS09730
uniprot id: A0A1P8JGW2
names: Similarity
messages: Belongs to the heat shock protein 90 family.

1122984:BWX39 RS01435
gene id: 1122984:BWX39_RS01435
uniprot id: A0A1P8JCF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1122984:BWX39 RS02095
gene id: 1122984:BWX39_RS02095
uniprot id: A0A1P8JCQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1122984:BWX39 RS09180
gene id: 1122984:BWX39_RS09180
uniprot id: A0A1P8JHU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1122984:BWX39 RS07905
gene id: 1122984:BWX39_RS07905
uniprot id: A0A1P8JFP4
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1122984:BWX39 RS06535
gene id: 1122984:BWX39_RS06535
uniprot id: A0A1P8JGA6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1122984:BWX39 RS08265
gene id: 1122984:BWX39_RS08265
uniprot id: A0A1P8JFU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1122984:BWX39 RS01840
gene id: 1122984:BWX39_RS01840
uniprot id: A0A1P8JCN4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1122984:BWX39 RS05105
gene id: 1122984:BWX39_RS05105
uniprot id: A0A1P8JEA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0114 family.
messages: Cell membrane
messages: Membrane

1122984:BWX39 RS00870
gene id: 1122984:BWX39_RS00870
uniprot id: A0A1P8JC43
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1122984:BWX39 RS02290
gene id: 1122984:BWX39_RS02290
uniprot id: A0A1P8JCU1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1122984:BWX39 RS06645
gene id: 1122984:BWX39_RS06645
uniprot id: A0A1P8JF01
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1122984:BWX39 RS07595
gene id: 1122984:BWX39_RS07595
uniprot id: A0A1P8JFH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

1122984:BWX39 RS10590
gene id: 1122984:BWX39_RS10590
uniprot id: A0A1P8JHB8
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1122984:BWX39 RS05340
gene id: 1122984:BWX39_RS05340
uniprot id: A0A1P8JEC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

1122984:BWX39 RS03175
gene id: 1122984:BWX39_RS03175
uniprot id: A0A1P8JDA1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1122984:BWX39 RS02655
gene id: 1122984:BWX39_RS02655
uniprot id: A0A1P8JD17
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS07195
gene id: 1122984:BWX39_RS07195
uniprot id: A0A1P8JF97
names: Similarity
messages: Belongs to the IMPACT family.

1122984:BWX39 RS10410
gene id: 1122984:BWX39_RS10410
uniprot id: A0A1P8JH85
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrF family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.

1122984:BWX39 RS10360
gene id: 1122984:BWX39_RS10360
uniprot id: A0A1P8JH82
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS06115
gene id: 1122984:BWX39_RS06115
uniprot id: A0A1P8JG97
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

1122984:BWX39 RS06040
gene id: 1122984:BWX39_RS06040
uniprot id: A0A1P8JES1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1122984:BWX39 RS08445
gene id: 1122984:BWX39_RS08445
uniprot id: A0A1P8JGD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1122984:BWX39 RS10820
gene id: 1122984:BWX39_RS10820
uniprot id: A0A1P8JHE0
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1122984:BWX39 RS03285
gene id: 1122984:BWX39_RS03285
uniprot id: A0A1P8JDB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1122984:BWX39 RS04090
gene id: 1122984:BWX39_RS04090
uniprot id: A0A1P8JG47
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1122984:BWX39 RS03475
gene id: 1122984:BWX39_RS03475
uniprot id: A0A1P8JDG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1122984:BWX39 RS03675
gene id: 1122984:BWX39_RS03675
uniprot id: A0A1P8JG43
names: Similarity
messages: Belongs to the UPF0102 family.

1122984:BWX39 RS06785
gene id: 1122984:BWX39_RS06785
uniprot id: A0A1P8JF75
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1122984:BWX39 RS00445
gene id: 1122984:BWX39_RS00445
uniprot id: A0A1P8JBW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1122984:BWX39 RS06760
gene id: 1122984:BWX39_RS06760
uniprot id: A0A1P8JF25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1122984:BWX39 RS04200
gene id: 1122984:BWX39_RS04200
uniprot id: A0A1P8JDT7
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

1122984:BWX39 RS06855
gene id: 1122984:BWX39_RS06855
uniprot id: A0A1P8JF59
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1122984:BWX39 RS10435
gene id: 1122984:BWX39_RS10435
uniprot id: A0A1P8JH87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1122984:BWX39 RS05660
gene id: 1122984:BWX39_RS05660
uniprot id: A0A1P8JEH4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1122984:BWX39 RS08290
gene id: 1122984:BWX39_RS08290
uniprot id: A0A1P8JFW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1122984:BWX39 RS00575
gene id: 1122984:BWX39_RS00575
uniprot id: A0A1P8JBY8
names: Similarity
messages: Belongs to the Vsr family.

1122984:BWX39 RS10470
gene id: 1122984:BWX39_RS10470
uniprot id: A0A1P8JH98
names: Similarity
messages: Belongs to the Skp family.

1122984:BWX39 RS04990
gene id: 1122984:BWX39_RS04990
uniprot id: A0A1P8JE96
names: Similarity
messages: Belongs to the RNA polymerase subunit omega family.

1122984:BWX39 RS01965
gene id: 1122984:BWX39_RS01965
uniprot id: A0A1P8JCN3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

1122984:BWX39 RS05425
gene id: 1122984:BWX39_RS05425
uniprot id: A0A1P8JEF4
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1122984:BWX39 RS00635
gene id: 1122984:BWX39_RS00635
uniprot id: A0A1P8JBZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

1122984:BWX39 RS07590
gene id: 1122984:BWX39_RS07590
uniprot id: A0A1P8JFI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1122984:BWX39 RS00625
gene id: 1122984:BWX39_RS00625
uniprot id: A0A1P8JBZ6
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1122984:BWX39 RS05650
gene id: 1122984:BWX39_RS05650
uniprot id: A0A1P8JEK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

1122984:BWX39 RS01405
gene id: 1122984:BWX39_RS01405
uniprot id: A0A1P8JCH4
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

1122984:BWX39 RS06120
gene id: 1122984:BWX39_RS06120
uniprot id: A0A1P8JEU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

1122984:BWX39 RS00895
gene id: 1122984:BWX39_RS00895
uniprot id: A0A1P8JC45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

1122984:BWX39 RS05700
gene id: 1122984:BWX39_RS05700
uniprot id: A0A1P8JG99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1122984:BWX39 RS01100
gene id: 1122984:BWX39_RS01100
uniprot id: A0A1P8JC86
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS07285
gene id: 1122984:BWX39_RS07285
uniprot id: A0A1P8JFF3
names: Similarity
messages: Belongs to the peptidase M16 family.

1122984:BWX39 RS03535
gene id: 1122984:BWX39_RS03535
uniprot id: A0A1P8JDH1
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

1122984:BWX39 RS01195
gene id: 1122984:BWX39_RS01195
uniprot id: A0A1P8JCD6
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1122984:BWX39 RS10080
gene id: 1122984:BWX39_RS10080
uniprot id: A0A1P8JHX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

1122984:BWX39 RS08135
gene id: 1122984:BWX39_RS08135
uniprot id: A0A1P8JFU3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1122984:BWX39 RS07020
gene id: 1122984:BWX39_RS07020
uniprot id: A0A1P8JF73
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS01390
gene id: 1122984:BWX39_RS01390
uniprot id: A0A1P8JCE4
names: Similarity
messages: Belongs to the SufE family.

1122984:BWX39 RS08340
gene id: 1122984:BWX39_RS08340
uniprot id: A0A1P8JFV9
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1122984:BWX39 RS04895
gene id: 1122984:BWX39_RS04895
uniprot id: A0A1P8JE62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1122984:BWX39 RS08430
gene id: 1122984:BWX39_RS08430
uniprot id: A0A1P8JFW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1122984:BWX39 RS07600
gene id: 1122984:BWX39_RS07600
uniprot id: A0A1P8JFI2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1122984:BWX39 RS09945
gene id: 1122984:BWX39_RS09945
uniprot id: A0A1P8JGY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1122984:BWX39 RS02470
gene id: 1122984:BWX39_RS02470
uniprot id: A0A1P8JCX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

1122984:BWX39 RS08225
gene id: 1122984:BWX39_RS08225
uniprot id: A0A1P8JFU8
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1122984:BWX39 RS07910
gene id: 1122984:BWX39_RS07910
uniprot id: A0A1P8JGB0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1122984:BWX39 RS06640
gene id: 1122984:BWX39_RS06640
uniprot id: A0A1P8JF24
names: Similarity
messages: Belongs to the transketolase family.

1122984:BWX39 RS08240
gene id: 1122984:BWX39_RS08240
uniprot id: A0A1P8JFV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1122984:BWX39 RS01530
gene id: 1122984:BWX39_RS01530
uniprot id: A0A1P8JG16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1122984:BWX39 RS02520
gene id: 1122984:BWX39_RS02520
uniprot id: A0A1P8JCX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1122984:BWX39 RS09310
gene id: 1122984:BWX39_RS09310
uniprot id: A0A1P8JGQ4
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.

1122984:BWX39 RS04560
gene id: 1122984:BWX39_RS04560
uniprot id: A0A1P8JE07
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS08855
gene id: 1122984:BWX39_RS08855
uniprot id: A0A1P8JGI1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1122984:BWX39 RS05735
gene id: 1122984:BWX39_RS05735
uniprot id: A0A1P8JG77
names: Caution
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS10010
gene id: 1122984:BWX39_RS10010
uniprot id: A0A1P8JH16
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1122984:BWX39 RS04165
gene id: 1122984:BWX39_RS04165
uniprot id: A0A1P8JDT9
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

1122984:BWX39 RS07925
gene id: 1122984:BWX39_RS07925
uniprot id: A0A1P8JFN6
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS07620
gene id: 1122984:BWX39_RS07620
uniprot id: A0A1P8JFI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

1122984:BWX39 RS11605
gene id: 1122984:BWX39_RS11605
uniprot id: A0A1P8JHU0
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

1122984:BWX39 RS02465
gene id: 1122984:BWX39_RS02465
uniprot id: A0A1P8JCX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

1122984:BWX39 RS04620
gene id: 1122984:BWX39_RS04620
uniprot id: A0A1P8JE17
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

1122984:BWX39 RS06230
gene id: 1122984:BWX39_RS06230
uniprot id: A0A1P8JEW4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS03260
gene id: 1122984:BWX39_RS03260
uniprot id: A0A1P8JDB3
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

1122984:BWX39 RS02940
gene id: 1122984:BWX39_RS02940
uniprot id: A0A1P8JD61
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

1122984:BWX39 RS01565
gene id: 1122984:BWX39_RS01565
uniprot id: A0A1P8JCG5
names: Similarity
messages: Belongs to the peptidase S26 family.

1122984:BWX39 RS06515
gene id: 1122984:BWX39_RS06515
uniprot id: A0A1P8JEZ6
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1122984:BWX39 RS04750
gene id: 1122984:BWX39_RS04750
uniprot id: A0A1P8JE35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1122984:BWX39 RS04155
gene id: 1122984:BWX39_RS04155
uniprot id: A0A1P8JDU9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1122984:BWX39 RS02900
gene id: 1122984:BWX39_RS02900
uniprot id: A0A1P8JD73
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

1122984:BWX39 RS07400
gene id: 1122984:BWX39_RS07400
uniprot id: A0A1P8JFG9
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS04840
gene id: 1122984:BWX39_RS04840
uniprot id: A0A1P8JE54
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS02120
gene id: 1122984:BWX39_RS02120
uniprot id: A0A1P8JCR8
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1122984:BWX39 RS06265
gene id: 1122984:BWX39_RS06265
uniprot id: A0A1P8JEU8
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS00735
gene id: 1122984:BWX39_RS00735
uniprot id: A0A1P8JC18
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1122984:BWX39 RS00410
gene id: 1122984:BWX39_RS00410
uniprot id: A0A1P8JBZ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1122984:BWX39 RS00210
gene id: 1122984:BWX39_RS00210
uniprot id: A0A1P8JBX1
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1122984:BWX39 RS07695
gene id: 1122984:BWX39_RS07695
uniprot id: A0A1P8JFK7
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

1122984:BWX39 RS08895
gene id: 1122984:BWX39_RS08895
uniprot id: A0A1P8JGH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1122984:BWX39 RS08245
gene id: 1122984:BWX39_RS08245
uniprot id: A0A1P8JFW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1122984:BWX39 RS06575
gene id: 1122984:BWX39_RS06575
uniprot id: A0A1P8JF04
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS01955
gene id: 1122984:BWX39_RS01955
uniprot id: A0A1P8JCN2
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS04035
gene id: 1122984:BWX39_RS04035
uniprot id: A0A1P8JDR7
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

1122984:BWX39 RS06775
gene id: 1122984:BWX39_RS06775
uniprot id: A0A1P8JF30
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1122984:BWX39 RS00340
gene id: 1122984:BWX39_RS00340
uniprot id: A0A1P8JBU8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS03870
gene id: 1122984:BWX39_RS03870
uniprot id: A0A1P8JDP7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

1122984:BWX39 RS08270
gene id: 1122984:BWX39_RS08270
uniprot id: A0A1P8JFT6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1122984:BWX39 RS05765
gene id: 1122984:BWX39_RS05765
uniprot id: A0A1P8JEM6
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

1122984:BWX39 RS07625
gene id: 1122984:BWX39_RS07625
uniprot id: A0A1P8JGB4
names: Similarity
messages: Belongs to the NusB family.

1122984:BWX39 RS01020
gene id: 1122984:BWX39_RS01020
uniprot id: A0A1P8JCB0
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

1122984:BWX39 RS07635
gene id: 1122984:BWX39_RS07635
uniprot id: A0A1P8JFI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1122984:BWX39 RS09830
gene id: 1122984:BWX39_RS09830
uniprot id: A0A1P8JGY2
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

1122984:BWX39 RS09685
gene id: 1122984:BWX39_RS09685
uniprot id: A0A1P8JHV8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1122984:BWX39 RS05945
gene id: 1122984:BWX39_RS05945
uniprot id: A0A1P8JEP5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1122984:BWX39 RS02330
gene id: 1122984:BWX39_RS02330
uniprot id: A0A1P8JCX6
names: Subcellular Location Annotation
messages: Cytoplasm

1122984:BWX39 RS07385
gene id: 1122984:BWX39_RS07385
uniprot id: A0A1P8JFF9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1122984:BWX39 RS07490
gene id: 1122984:BWX39_RS07490
uniprot id: A0A1P8JFH8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

1122984:BWX39 RS02315
gene id: 1122984:BWX39_RS02315
uniprot id: A0A1P8JCU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1122984:BWX39 RS07035
gene id: 1122984:BWX39_RS07035
uniprot id: A0A1P8JF98
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS01165
gene id: 1122984:BWX39_RS01165
uniprot id: A0A1P8JCA3
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS07245
gene id: 1122984:BWX39_RS07245
uniprot id: A0A1P8JFC3
names: Similarity
messages: Belongs to the DEAD box helicase family.

1122984:BWX39 RS10440
gene id: 1122984:BWX39_RS10440
uniprot id: A0A1P8JH95
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS08980
gene id: 1122984:BWX39_RS08980
uniprot id: A0A1P8JGK3
names: Similarity
messages: Belongs to the peptidase C69 family.

1122984:BWX39 RS04120
gene id: 1122984:BWX39_RS04120
uniprot id: A0A1P8JG70
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.

1122984:BWX39 RS01440
gene id: 1122984:BWX39_RS01440
uniprot id: A0A1P8JCF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1122984:BWX39 RS08370
gene id: 1122984:BWX39_RS08370
uniprot id: A0A1P8JFW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1122984:BWX39 RS01340
gene id: 1122984:BWX39_RS01340
uniprot id: A0A1P8JCD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1122984:BWX39 RS02880
gene id: 1122984:BWX39_RS02880
uniprot id: A0A1P8JD63
names: Similarity
messages: Belongs to the disproportionating enzyme family.

1122984:BWX39 RS03430
gene id: 1122984:BWX39_RS03430
uniprot id: A0A1P8JDF6
names: Similarity
messages: Belongs to the CvfB family.

1122984:BWX39 RS06540
gene id: 1122984:BWX39_RS06540
uniprot id: A0A1P8JEY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1122984:BWX39 RS01850
gene id: 1122984:BWX39_RS01850
uniprot id: A0A1P8JCL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1122984:BWX39 RS01540
gene id: 1122984:BWX39_RS01540
uniprot id: A0A1P8JCG6
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

1122984:BWX39 RS05640
gene id: 1122984:BWX39_RS05640
uniprot id: A0A1P8JEJ0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1122984:BWX39 RS06280
gene id: 1122984:BWX39_RS06280
uniprot id: A0A1P8JEW0
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the NapC/NirT/NrfH family.
messages: Binds 4 heme groups per subunit.

1122984:BWX39 RS04720
gene id: 1122984:BWX39_RS04720
uniprot id: A0A1P8JE15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

1122984:BWX39 RS00840
gene id: 1122984:BWX39_RS00840
uniprot id: A0A1P8JC35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1122984:BWX39 RS07335
gene id: 1122984:BWX39_RS07335
uniprot id: A0A1P8JFF7
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS04770
gene id: 1122984:BWX39_RS04770
uniprot id: A0A1P8JE28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

1122984:BWX39 RS01045
gene id: 1122984:BWX39_RS01045
uniprot id: A0A1P8JC74
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS04030
gene id: 1122984:BWX39_RS04030
uniprot id: A0A1P8JDQ4
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

1122984:BWX39 RS05710
gene id: 1122984:BWX39_RS05710
uniprot id: A0A1P8JEL8
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

1122984:BWX39 RS06165
gene id: 1122984:BWX39_RS06165
uniprot id: A0A1P8JES8
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

1122984:BWX39 RS08485
gene id: 1122984:BWX39_RS08485
uniprot id: A0A1P8JG04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1122984:BWX39 RS01380
gene id: 1122984:BWX39_RS01380
uniprot id: A0A1P8JCD9
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1122984:BWX39 RS08455
gene id: 1122984:BWX39_RS08455
uniprot id: A0A1P8JFX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1122984:BWX39 RS08085
gene id: 1122984:BWX39_RS08085
uniprot id: A0A1P8JFT3
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS07685
gene id: 1122984:BWX39_RS07685
uniprot id: A0A1P8JFJ5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1122984:BWX39 RS11070
gene id: 1122984:BWX39_RS11070
uniprot id: A0A1P8JHH5
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

1122984:BWX39 RS03060
gene id: 1122984:BWX39_RS03060
uniprot id: A0A1P8JD77
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1122984:BWX39 RS08360
gene id: 1122984:BWX39_RS08360
uniprot id: A0A1P8JFX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1122984:BWX39 RS02715
gene id: 1122984:BWX39_RS02715
uniprot id: A0A1P8JD20
names: Similarity
messages: Belongs to the SusD family.

1122984:BWX39 RS02405
gene id: 1122984:BWX39_RS02405
uniprot id: A0A1P8JCW6
names: Similarity
messages: Belongs to the peptidase M16 family.

1122984:BWX39 RS10210
gene id: 1122984:BWX39_RS10210
uniprot id: A0A1P8JH54
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1122984:BWX39 RS01810
gene id: 1122984:BWX39_RS01810
uniprot id: A0A1P8JCN5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1122984:BWX39 RS05570
gene id: 1122984:BWX39_RS05570
uniprot id: A0A1P8JEI7
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS02320
gene id: 1122984:BWX39_RS02320
uniprot id: A0A1P8JCU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

1122984:BWX39 RS01005
gene id: 1122984:BWX39_RS01005
uniprot id: A0A1P8JC68
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

1122984:BWX39 RS10925
gene id: 1122984:BWX39_RS10925
uniprot id: A0A1P8JHE1
names: Similarity
messages: Belongs to the glycosyl hydrolase 24 family.

1122984:BWX39 RS10490
gene id: 1122984:BWX39_RS10490
uniprot id: A0A1P8JHA2
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1122984:BWX39 RS02115
gene id: 1122984:BWX39_RS02115
uniprot id: A0A1P8JCS9
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1122984:BWX39 RS06865
gene id: 1122984:BWX39_RS06865
uniprot id: A0A1P8JF49
names: Similarity
messages: Belongs to the peptidase S41A family.

1122984:BWX39 RS08255
gene id: 1122984:BWX39_RS08255
uniprot id: A0A1P8JFU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1122984:BWX39 RS03415
gene id: 1122984:BWX39_RS03415
uniprot id: A0A1P8JG49
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS03200
gene id: 1122984:BWX39_RS03200
uniprot id: A0A1P8JDA9
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1122984:BWX39 RS02570
gene id: 1122984:BWX39_RS02570
uniprot id: A0A1P8JD09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1122984:BWX39 RS03805
gene id: 1122984:BWX39_RS03805
uniprot id: A0A1P8JDL2
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1122984:BWX39 RS00680
gene id: 1122984:BWX39_RS00680
uniprot id: A0A1P8JC08
names: Similarity
messages: Belongs to the Skp family.

1122984:BWX39 RS03530
gene id: 1122984:BWX39_RS03530
uniprot id: A0A1P8JDF9
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS07230
gene id: 1122984:BWX39_RS07230
uniprot id: A0A1P8JFD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1122984:BWX39 RS03070
gene id: 1122984:BWX39_RS03070
uniprot id: A0A1P8JD92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Cytoplasm

1122984:BWX39 RS09900
gene id: 1122984:BWX39_RS09900
uniprot id: A0A1P8JGZ5
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1122984:BWX39 RS02600
gene id: 1122984:BWX39_RS02600
uniprot id: A0A1P8JCZ9
names: Similarity
messages: Belongs to the asparaginase 1 family.

1122984:BWX39 RS05850
gene id: 1122984:BWX39_RS05850
uniprot id: A0A1P8JEL3
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

1122984:BWX39 RS07540
gene id: 1122984:BWX39_RS07540
uniprot id: A0A1P8JFG2
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS05295
gene id: 1122984:BWX39_RS05295
uniprot id: A0A1P8JED0
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS02150
gene id: 1122984:BWX39_RS02150
uniprot id: A0A1P8JCR9
names: Similarity
messages: Belongs to the SusD family.

1122984:BWX39 RS11655
gene id: 1122984:BWX39_RS11655
uniprot id: A0A1P8JHV0
names: Similarity
messages: Belongs to the peptidase M16 family.

1122984:BWX39 RS07390
gene id: 1122984:BWX39_RS07390
uniprot id: A0A1P8JFD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

1122984:BWX39 RS07830
gene id: 1122984:BWX39_RS07830
uniprot id: A0A1P8JFM4
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS00505
gene id: 1122984:BWX39_RS00505
uniprot id: A0A1P8JBX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1122984:BWX39 RS08050
gene id: 1122984:BWX39_RS08050
uniprot id: A0A1P8JFR0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS04295
gene id: 1122984:BWX39_RS04295
uniprot id: A0A1P8JDU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Cytoplasm

1122984:BWX39 RS09545
gene id: 1122984:BWX39_RS09545
uniprot id: A0A1P8JGR7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1122984:BWX39 RS08195
gene id: 1122984:BWX39_RS08195
uniprot id: A0A1P8JFS5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

1122984:BWX39 RS07900
gene id: 1122984:BWX39_RS07900
uniprot id: A0A1P8JFN2
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

1122984:BWX39 RS09635
gene id: 1122984:BWX39_RS09635
uniprot id: A0A1P8JGT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1122984:BWX39 RS02575
gene id: 1122984:BWX39_RS02575
uniprot id: A0A1P8JCZ1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated Cas9 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA). Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs. PAM recognition is also required for catalytic activity.
messages: Has 2 endonuclease domains. The discontinuous RuvC-like domain cleaves the target DNA noncomplementary to crRNA while the HNH nuclease domain cleaves the target DNA complementary to crRNA.
messages: Monomer. Binds crRNA and tracrRNA.

1122984:BWX39 RS07495
gene id: 1122984:BWX39_RS07495
uniprot id: A0A1P8JFG3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

1122984:BWX39 RS10340
gene id: 1122984:BWX39_RS10340
uniprot id: A0A1P8JH77
names: Similarity
messages: Belongs to the class-I fumarase family.

1122984:BWX39 RS00705
gene id: 1122984:BWX39_RS00705
uniprot id: A0A1P8JC11
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1122984:BWX39 RS08915
gene id: 1122984:BWX39_RS08915
uniprot id: A0A1P8JGE7
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS06140
gene id: 1122984:BWX39_RS06140
uniprot id: A0A1P8JES4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

1122984:BWX39 RS01525
gene id: 1122984:BWX39_RS01525
uniprot id: A0A1P8JCG1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1122984:BWX39 RS09540
gene id: 1122984:BWX39_RS09540
uniprot id: A0A1P8JGU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1122984:BWX39 RS02825
gene id: 1122984:BWX39_RS02825
uniprot id: A0A1P8JD46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1122984:BWX39 RS09335
gene id: 1122984:BWX39_RS09335
uniprot id: A0A1P8JGQ0
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

1122984:BWX39 RS04875
gene id: 1122984:BWX39_RS04875
uniprot id: A0A1P8JE71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1122984:BWX39 RS04980
gene id: 1122984:BWX39_RS04980
uniprot id: A0A1P8JE81
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1122984:BWX39 RS02100
gene id: 1122984:BWX39_RS02100
uniprot id: A0A1P8JCP7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1122984:BWX39 RS08850
gene id: 1122984:BWX39_RS08850
uniprot id: A0A1P8JGH3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1122984:BWX39 RS02675
gene id: 1122984:BWX39_RS02675
uniprot id: A0A1P8JD35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class A bacterial acid phosphatase family.
messages: Periplasm

1122984:BWX39 RS05500
gene id: 1122984:BWX39_RS05500
uniprot id: A0A1P8JEF6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1122984:BWX39 RS03335
gene id: 1122984:BWX39_RS03335
uniprot id: A0A1P8JDD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1122984:BWX39 RS09670
gene id: 1122984:BWX39_RS09670
uniprot id: A0A1P8JGV2
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS08435
gene id: 1122984:BWX39_RS08435
uniprot id: A0A1P8JFZ2
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1122984:BWX39 RS02485
gene id: 1122984:BWX39_RS02485
uniprot id: A0A1P8JCY4
names: Similarity
messages: Belongs to the YicC/YloC family.

1122984:BWX39 RS03975
gene id: 1122984:BWX39_RS03975
uniprot id: A0A1P8JDR9
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS00695
gene id: 1122984:BWX39_RS00695
uniprot id: A0A1P8JC48
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase H family.
messages: Binds 2 metal ions per subunit. Manganese or magnesium.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

1122984:BWX39 RS08345
gene id: 1122984:BWX39_RS08345
uniprot id: A0A1P8JFW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1122984:BWX39 RS03300
gene id: 1122984:BWX39_RS03300
uniprot id: A0A1P8JDC5
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS01360
gene id: 1122984:BWX39_RS01360
uniprot id: A0A1P8JCG7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1122984:BWX39 RS00335
gene id: 1122984:BWX39_RS00335
uniprot id: A0A1P8JBU9
names: Similarity
messages: Belongs to the peptidase M16 family.

1122984:BWX39 RS03100
gene id: 1122984:BWX39_RS03100
uniprot id: A0A1P8JD90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

1122984:BWX39 RS08275
gene id: 1122984:BWX39_RS08275
uniprot id: A0A1P8JFV7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1122984:BWX39 RS04515
gene id: 1122984:BWX39_RS04515
uniprot id: A0A1P8JE00
names: Cofactor
names: Similarity
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1122984:BWX39 RS06340
gene id: 1122984:BWX39_RS06340
uniprot id: A0A1P8JEV7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1122984:BWX39 RS01135
gene id: 1122984:BWX39_RS01135
uniprot id: A0A1P8JCC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAE transporter (TC 2.A.81) family.
messages: Cell membrane
messages: Membrane

1122984:BWX39 RS03775
gene id: 1122984:BWX39_RS03775
uniprot id: A0A1P8JDK0
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

1122984:BWX39 RS02375
gene id: 1122984:BWX39_RS02375
uniprot id: A0A1P8JCW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1122984:BWX39 RS07935
gene id: 1122984:BWX39_RS07935
uniprot id: A0A1P8JFN7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1122984:BWX39 RS07465
gene id: 1122984:BWX39_RS07465
uniprot id: A0A1P8JFF5
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS01295
gene id: 1122984:BWX39_RS01295
uniprot id: A0A1P8JCB5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1122984:BWX39 RS07350
gene id: 1122984:BWX39_RS07350
uniprot id: A0A1P8JFE8
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

1122984:BWX39 RS04150
gene id: 1122984:BWX39_RS04150
uniprot id: A0A1P8JDU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

1122984:BWX39 RS08860
gene id: 1122984:BWX39_RS08860
uniprot id: A0A1P8JGF9
names: Similarity
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.

1122984:BWX39 RS09975
gene id: 1122984:BWX39_RS09975
uniprot id: A0A1P8JGY6
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1122984:BWX39 RS10160
gene id: 1122984:BWX39_RS10160
uniprot id: A0A1P8JH30
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1122984:BWX39 RS07365
gene id: 1122984:BWX39_RS07365
uniprot id: A0A1P8JFD0
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1122984:BWX39 RS00830
gene id: 1122984:BWX39_RS00830
uniprot id: A0A1P8JC40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

1122984:BWX39 RS03685
gene id: 1122984:BWX39_RS03685
uniprot id: A0A1P8JDI9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS03055
gene id: 1122984:BWX39_RS03055
uniprot id: A0A1P8JD78
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

1122984:BWX39 RS00200
gene id: 1122984:BWX39_RS00200
uniprot id: A0A1P8JBT1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1122984:BWX39 RS08280
gene id: 1122984:BWX39_RS08280
uniprot id: A0A1P8JFU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1122984:BWX39 RS10640
gene id: 1122984:BWX39_RS10640
uniprot id: A0A1P8JHB0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

1122984:BWX39 RS07440
gene id: 1122984:BWX39_RS07440
uniprot id: A0A1P8JFE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1122984:BWX39 RS03215
gene id: 1122984:BWX39_RS03215
uniprot id: A0A1P8JDB4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1122984:BWX39 RS07880
gene id: 1122984:BWX39_RS07880
uniprot id: A0A1P8JFN3
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1122984:BWX39 RS05490
gene id: 1122984:BWX39_RS05490
uniprot id: A0A1P8JEH6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1122984:BWX39 RS07060
gene id: 1122984:BWX39_RS07060
uniprot id: A0A1P8JF95
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS05440
gene id: 1122984:BWX39_RS05440
uniprot id: A0A1P8JEG5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Cytoplasm
messages: Homodimer.

1122984:BWX39 RS01320
gene id: 1122984:BWX39_RS01320
uniprot id: A0A1P8JCC3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1122984:BWX39 RS04350
gene id: 1122984:BWX39_RS04350
uniprot id: A0A1P8JDV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1122984:BWX39 RS04005
gene id: 1122984:BWX39_RS04005
uniprot id: A0A1P8JDP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1122984:BWX39 RS10375
gene id: 1122984:BWX39_RS10375
uniprot id: A0A1P8JH75
names: Similarity
messages: Belongs to the GARS family.

1122984:BWX39 RS06565
gene id: 1122984:BWX39_RS06565
uniprot id: A0A1P8JF35
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1122984:BWX39 RS06385
gene id: 1122984:BWX39_RS06385
uniprot id: A0A1P8JEV3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS07630
gene id: 1122984:BWX39_RS07630
uniprot id: A0A1P8JFK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1122984:BWX39 RS02170
gene id: 1122984:BWX39_RS02170
uniprot id: A0A1P8JCV6
names: Similarity
messages: Belongs to the peptidase S8 family.

1122984:BWX39 RS02750
gene id: 1122984:BWX39_RS02750
uniprot id: A0A1P8JD25
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1122984:BWX39 RS10120
gene id: 1122984:BWX39_RS10120
uniprot id: A0A1P8JH35
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1122984:BWX39 RS08730
gene id: 1122984:BWX39_RS08730
uniprot id: A0A1P8JGE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1122984:BWX39 RS05800
gene id: 1122984:BWX39_RS05800
uniprot id: A0A1P8JEM0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1122984:BWX39 RS03280
gene id: 1122984:BWX39_RS03280
uniprot id: A0A1P8JDB9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1122984:BWX39 RS01790
gene id: 1122984:BWX39_RS01790
uniprot id: A0A1P8JCL6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1122984:BWX39 RS04915
gene id: 1122984:BWX39_RS04915
uniprot id: A0A1P8JE69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1122984:BWX39 RS08890
gene id: 1122984:BWX39_RS08890
uniprot id: A0A1P8JGI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

1122984:BWX39 RS08325
gene id: 1122984:BWX39_RS08325
uniprot id: A0A1P8JFU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1122984:BWX39 RS02640
gene id: 1122984:BWX39_RS02640
uniprot id: A0A1P8JD03
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

1122984:BWX39 RS00070
gene id: 1122984:BWX39_RS00070
uniprot id: A0A1P8JBP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S41B family.
messages: Cytoplasm
messages: Degrades oligopeptides.

1122984:BWX39 RS10185
gene id: 1122984:BWX39_RS10185
uniprot id: A0A1P8JH32
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1122984:BWX39 RS02840
gene id: 1122984:BWX39_RS02840
uniprot id: A0A1P8JD38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS10480
gene id: 1122984:BWX39_RS10480
uniprot id: A0A1P8JH80
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS10705
gene id: 1122984:BWX39_RS10705
uniprot id: A0A1P8JHC1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

1122984:BWX39 RS06195
gene id: 1122984:BWX39_RS06195
uniprot id: A0A1P8JES2
names: Similarity
messages: Belongs to the DEAD box helicase family.

1122984:BWX39 RS10225
gene id: 1122984:BWX39_RS10225
uniprot id: A0A1P8JH38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

1122984:BWX39 RS01980
gene id: 1122984:BWX39_RS01980
uniprot id: A0A1P8JCQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

1122984:BWX39 RS09980
gene id: 1122984:BWX39_RS09980
uniprot id: A0A1P8JH06
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

1122984:BWX39 RS10575
gene id: 1122984:BWX39_RS10575
uniprot id: A0A1P8JH97
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1122984:BWX39 RS09985
gene id: 1122984:BWX39_RS09985
uniprot id: A0A1P8JH13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1122984:BWX39 RS06080
gene id: 1122984:BWX39_RS06080
uniprot id: A0A1P8JER2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1122984:BWX39 RS08330
gene id: 1122984:BWX39_RS08330
uniprot id: A0A1P8JFX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1122984:BWX39 RS04575
gene id: 1122984:BWX39_RS04575
uniprot id: A0A1P8JDZ1
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS03770
gene id: 1122984:BWX39_RS03770
uniprot id: A0A1P8JDL5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1122984:BWX39 RS03295
gene id: 1122984:BWX39_RS03295
uniprot id: A0A1P8JDE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1122984:BWX39 RS02090
gene id: 1122984:BWX39_RS02090
uniprot id: A0A1P8JCP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1122984:BWX39 RS04160
gene id: 1122984:BWX39_RS04160
uniprot id: A0A1P8JDS3
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

1122984:BWX39 RS10700
gene id: 1122984:BWX39_RS10700
uniprot id: A0A1P8JHW5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

1122984:BWX39 RS02990
gene id: 1122984:BWX39_RS02990
uniprot id: A0A1P8JG38
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1122984:BWX39 RS00165
gene id: 1122984:BWX39_RS00165
uniprot id: A0A1P8JBV1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1122984:BWX39 RS05250
gene id: 1122984:BWX39_RS05250
uniprot id: A0A1P8JED2
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

1122984:BWX39 RS08125
gene id: 1122984:BWX39_RS08125
uniprot id: A0A1P8JFR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diaminopimelate dehydrogenase family.
messages: Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate.
messages: Homodimer.

1122984:BWX39 RS08035
gene id: 1122984:BWX39_RS08035
uniprot id: A0A1P8JFQ3
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

1122984:BWX39 RS03105
gene id: 1122984:BWX39_RS03105
uniprot id: A0A1P8JD89
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1122984:BWX39 RS08300
gene id: 1122984:BWX39_RS08300
uniprot id: A0A1P8JFV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1122984:BWX39 RS08320
gene id: 1122984:BWX39_RS08320
uniprot id: A0A1P8JFV5
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1122984:BWX39 RS03920
gene id: 1122984:BWX39_RS03920
uniprot id: A0A1P8JDQ7
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1122984:BWX39 RS02760
gene id: 1122984:BWX39_RS02760
uniprot id: A0A1P8JD22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1122984:BWX39 RS09735
gene id: 1122984:BWX39_RS09735
uniprot id: A0A1P8JGV6
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS04490
gene id: 1122984:BWX39_RS04490
uniprot id: A0A1P8JDZ5
names: Similarity
messages: Belongs to the arginase family.

1122984:BWX39 RS04255
gene id: 1122984:BWX39_RS04255
uniprot id: A0A1P8JDU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

1122984:BWX39 RS09570
gene id: 1122984:BWX39_RS09570
uniprot id: A0A1P8JGT6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1122984:BWX39 RS08740
gene id: 1122984:BWX39_RS08740
uniprot id: A0A1P8JGG1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS08260
gene id: 1122984:BWX39_RS08260
uniprot id: A0A1P8JFW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1122984:BWX39 RS01000
gene id: 1122984:BWX39_RS01000
uniprot id: A0A1P8JC73
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS05355
gene id: 1122984:BWX39_RS05355
uniprot id: A0A1P8JEF1
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

1122984:BWX39 RS05600
gene id: 1122984:BWX39_RS05600
uniprot id: A0A1P8JEJ1
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

1122984:BWX39 RS05750
gene id: 1122984:BWX39_RS05750
uniprot id: A0A1P8JEL0
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1122984:BWX39 RS02105
gene id: 1122984:BWX39_RS02105
uniprot id: A0A1P8JCS3
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1122984:BWX39 RS10545
gene id: 1122984:BWX39_RS10545
uniprot id: A0A1P8JHW6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1122984:BWX39 RS08190
gene id: 1122984:BWX39_RS08190
uniprot id: A0A1P8JFV3
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1122984:BWX39 RS08875
gene id: 1122984:BWX39_RS08875
uniprot id: A0A1P8JGG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1122984:BWX39 RS07610
gene id: 1122984:BWX39_RS07610
uniprot id: A0A1P8JFJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1122984:BWX39 RS08425
gene id: 1122984:BWX39_RS08425
uniprot id: A0A1P8JFX7
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

1122984:BWX39 RS09125
gene id: 1122984:BWX39_RS09125
uniprot id: A0A1P8JGM4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1122984:BWX39 RS03135
gene id: 1122984:BWX39_RS03135
uniprot id: A0A1P8JD84
names: Similarity
messages: Belongs to the ParB family.

1122984:BWX39 RS01245
gene id: 1122984:BWX39_RS01245
uniprot id: A0A1P8JCA5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1122984:BWX39 RS10415
gene id: 1122984:BWX39_RS10415
uniprot id: A0A1P8JH72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1122984:BWX39 RS02180
gene id: 1122984:BWX39_RS02180
uniprot id: A0A1P8JCS6
names: Similarity
messages: Belongs to the peptidase S41A family.

1122984:BWX39 RS01335
gene id: 1122984:BWX39_RS01335
uniprot id: A0A1P8JCD0
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1122984:BWX39 RS08530
gene id: 1122984:BWX39_RS08530
uniprot id: A0A1P8JFY8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

1122984:BWX39 RS04410
gene id: 1122984:BWX39_RS04410
uniprot id: A0A1P8JDX3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1122984:BWX39 RS00675
gene id: 1122984:BWX39_RS00675
uniprot id: A0A1P8JC10
names: Similarity
messages: Belongs to the Skp family.

1122984:BWX39 RS05380
gene id: 1122984:BWX39_RS05380
uniprot id: A0A1P8JEF5
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1122984:BWX39 RS01330
gene id: 1122984:BWX39_RS01330
uniprot id: A0A1P8JCC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1122984:BWX39 RS02975
gene id: 1122984:BWX39_RS02975
uniprot id: A0A1P8JD83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

1122984:BWX39 RS06900
gene id: 1122984:BWX39_RS06900
uniprot id: A0A1P8JF47
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1122984:BWX39 RS10300
gene id: 1122984:BWX39_RS10300
uniprot id: A0A1P8JH63
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methylaspartate mutase GlmS subunit family.
messages: Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
messages: Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS01725
gene id: 1122984:BWX39_RS01725
uniprot id: A0A1P8JCJ9
names: Similarity
messages: Belongs to the ribF family.

1122984:BWX39 RS10635
gene id: 1122984:BWX39_RS10635
uniprot id: A0A1P8JHZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

1122984:BWX39 RS06765
gene id: 1122984:BWX39_RS06765
uniprot id: A0A1P8JF36
names: Similarity
messages: Belongs to the asparaginase 1 family.

1122984:BWX39 RS00985
gene id: 1122984:BWX39_RS00985
uniprot id: A0A1P8JC62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1122984:BWX39 RS08055
gene id: 1122984:BWX39_RS08055
uniprot id: A0A1P8JFQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

1122984:BWX39 RS03265
gene id: 1122984:BWX39_RS03265
uniprot id: A0A1P8JDC4
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1122984:BWX39 RS05360
gene id: 1122984:BWX39_RS05360
uniprot id: A0A1P8JEF7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1122984:BWX39 RS04400
gene id: 1122984:BWX39_RS04400
uniprot id: A0A1P8JDX9
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

1122984:BWX39 RS03470
gene id: 1122984:BWX39_RS03470
uniprot id: A0A1P8JDF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1122984:BWX39 RS09235
gene id: 1122984:BWX39_RS09235
uniprot id: A0A1P8JGP6
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

1122984:BWX39 RS00150
gene id: 1122984:BWX39_RS00150
uniprot id: A0A1P8JBS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

1122984:BWX39 RS07185
gene id: 1122984:BWX39_RS07185
uniprot id: A0A1P8JFB7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1122984:BWX39 RS05285
gene id: 1122984:BWX39_RS05285
uniprot id: A0A1P8JEC3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1122984:BWX39 RS03210
gene id: 1122984:BWX39_RS03210
uniprot id: A0A1P8JDA3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1122984:BWX39 RS00835
gene id: 1122984:BWX39_RS00835
uniprot id: A0A1P8JC38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

1122984:BWX39 RS08230
gene id: 1122984:BWX39_RS08230
uniprot id: A0A1P8JFT5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1122984:BWX39 RS11405
gene id: 1122984:BWX39_RS11405
uniprot id: A0A1P8JHR0
names: Similarity
messages: Belongs to the peptidase S8 family.

1122984:BWX39 RS02565
gene id: 1122984:BWX39_RS02565
uniprot id: A0A1P8JG39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1122984:BWX39 RS04690
gene id: 1122984:BWX39_RS04690
uniprot id: A0A1P8JG78
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1122984:BWX39 RS05485
gene id: 1122984:BWX39_RS05485
uniprot id: A0A1P8JEE7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1122984:BWX39 RS07415
gene id: 1122984:BWX39_RS07415
uniprot id: A0A1P8JFF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1122984:BWX39 RS08680
gene id: 1122984:BWX39_RS08680
uniprot id: A0A1P8JGC9
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS00140
gene id: 1122984:BWX39_RS00140
uniprot id: A0A1P8JBR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

1122984:BWX39 RS07655
gene id: 1122984:BWX39_RS07655
uniprot id: A0A1P8JFJ1
names: Similarity
messages: Belongs to the peptidase S13 family.

1122984:BWX39 RS06650
gene id: 1122984:BWX39_RS06650
uniprot id: A0A1P8JF08
names: Similarity
messages: Belongs to the pyruvate kinase family.

1122984:BWX39 RS02145
gene id: 1122984:BWX39_RS02145
uniprot id: A0A1P8JCQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1122984:BWX39 RS00485
gene id: 1122984:BWX39_RS00485
uniprot id: A0A1P8JBX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1122984:BWX39 RS05965
gene id: 1122984:BWX39_RS05965
uniprot id: A0A1P8JEN6
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

1122984:BWX39 RS05050
gene id: 1122984:BWX39_RS05050
uniprot id: A0A1P8JE94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1122984:BWX39 RS06425
gene id: 1122984:BWX39_RS06425
uniprot id: A0A1P8JEY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

1122984:BWX39 RS07065
gene id: 1122984:BWX39_RS07065
uniprot id: A0A1P8JF94
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS05480
gene id: 1122984:BWX39_RS05480
uniprot id: A0A1P8JEG6
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

1122984:BWX39 RS11680
gene id: 1122984:BWX39_RS11680
uniprot id: A0A1P8JGE7
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS00450
gene id: 1122984:BWX39_RS00450
uniprot id: A0A1P8JBW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1122984:BWX39 RS01475
gene id: 1122984:BWX39_RS01475
uniprot id: A0A1P8JCF2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1122984:BWX39 RS08250
gene id: 1122984:BWX39_RS08250
uniprot id: A0A1P8JFU1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1122984:BWX39 RS09345
gene id: 1122984:BWX39_RS09345
uniprot id: A0A1P8JGQ1
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1122984:BWX39 RS09525
gene id: 1122984:BWX39_RS09525
uniprot id: A0A1P8JGS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family.
messages: Cytoplasm

1122984:BWX39 RS10540
gene id: 1122984:BWX39_RS10540
uniprot id: A0A1P8JHA6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1122984:BWX39 RS04250
gene id: 1122984:BWX39_RS04250
uniprot id: A0A1P8JDU7
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1122984:BWX39 RS02335
gene id: 1122984:BWX39_RS02335
uniprot id: A0A1P8JCZ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS03905
gene id: 1122984:BWX39_RS03905
uniprot id: A0A1P8JDM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1122984:BWX39 RS01825
gene id: 1122984:BWX39_RS01825
uniprot id: A0A1P8JCM0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

1122984:BWX39 RS09130
gene id: 1122984:BWX39_RS09130
uniprot id: A0A1P8JGL1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1122984:BWX39 RS04890
gene id: 1122984:BWX39_RS04890
uniprot id: A0A1P8JE56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1122984:BWX39 RS08335
gene id: 1122984:BWX39_RS08335
uniprot id: A0A1P8JFV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1122984:BWX39 RS10625
gene id: 1122984:BWX39_RS10625
uniprot id: A0A1P8JHA9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1122984:BWX39 RS10555
gene id: 1122984:BWX39_RS10555
uniprot id: A0A1P8JH89
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

1122984:BWX39 RS05985
gene id: 1122984:BWX39_RS05985
uniprot id: A0A1P8JER0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1122984:BWX39 RS10315
gene id: 1122984:BWX39_RS10315
uniprot id: A0A1P8JH65
names: Similarity
names: Subunit
messages: Belongs to the methylaspartate ammonia-lyase family.
messages: Homodimer.

1122984:BWX39 RS07210
gene id: 1122984:BWX39_RS07210
uniprot id: A0A1P8JFA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1122984:BWX39 RS02195
gene id: 1122984:BWX39_RS02195
uniprot id: A0A1P8JCU4
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

1122984:BWX39 RS04365
gene id: 1122984:BWX39_RS04365
uniprot id: A0A1P8JDY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1122984:BWX39 RS06950
gene id: 1122984:BWX39_RS06950
uniprot id: A0A1P8JF56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

1122984:BWX39 RS00920
gene id: 1122984:BWX39_RS00920
uniprot id: A0A1P8JC57
names: Similarity
messages: Belongs to the peptidase M13 family.

1122984:BWX39 RS09000
gene id: 1122984:BWX39_RS09000
uniprot id: A0A1P8JGI5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1122984:BWX39 RS10810
gene id: 1122984:BWX39_RS10810
uniprot id: A0A1P8JHD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1122984:BWX39 RS06490
gene id: 1122984:BWX39_RS06490
uniprot id: A0A1P8JEY9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

1122984:BWX39 RS09490
gene id: 1122984:BWX39_RS09490
uniprot id: A0A1P8JGQ8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1122984:BWX39 RS10725
gene id: 1122984:BWX39_RS10725
uniprot id: A0A1P8JHB4
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

1122984:BWX39 RS03550
gene id: 1122984:BWX39_RS03550
uniprot id: A0A1P8JDH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1122984:BWX39 RS02230
gene id: 1122984:BWX39_RS02230
uniprot id: A0A1P8JCU3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

1122984:BWX39 RS08410
gene id: 1122984:BWX39_RS08410
uniprot id: A0A1P8JFW6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1122984:BWX39 RS06955
gene id: 1122984:BWX39_RS06955
uniprot id: A0A1P8JF90
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1122984:BWX39 RS01370
gene id: 1122984:BWX39_RS01370
uniprot id: A0A1P8JCD2
names: Similarity
messages: Belongs to the UPF0145 family.

1122984:BWX39 RS04070
gene id: 1122984:BWX39_RS04070
uniprot id: A0A1P8JDR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

1122984:BWX39 RS07380
gene id: 1122984:BWX39_RS07380
uniprot id: A0A1P8JFF4
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1122984:BWX39 RS08550
gene id: 1122984:BWX39_RS08550
uniprot id: A0A1P8JFY7
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

1122984:BWX39 RS08685
gene id: 1122984:BWX39_RS08685
uniprot id: A0A1P8JGE3
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS07105
gene id: 1122984:BWX39_RS07105
uniprot id: A0A1P8JF92
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1122984:BWX39 RS03145
gene id: 1122984:BWX39_RS03145
uniprot id: A0A1P8JDB8
names: Similarity
messages: Belongs to the transglycosylase Slt family.

1122984:BWX39 RS00180
gene id: 1122984:BWX39_RS00180
uniprot id: A0A1P8JBS4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1122984:BWX39 RS11440
gene id: 1122984:BWX39_RS11440
uniprot id: A0A1P8JHZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1122984:BWX39 RS00330
gene id: 1122984:BWX39_RS00330
uniprot id: A0A1P8JBU5
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

1122984:BWX39 RS00545
gene id: 1122984:BWX39_RS00545
uniprot id: A0A1P8JBY7
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1122984:BWX39 RS05630
gene id: 1122984:BWX39_RS05630
uniprot id: A0A1P8JEI1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

1122984:BWX39 RS03690
gene id: 1122984:BWX39_RS03690
uniprot id: A0A1P8JDJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

1122984:BWX39 RS00815
gene id: 1122984:BWX39_RS00815
uniprot id: A0A1P8JC36
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

1122984:BWX39 RS03015
gene id: 1122984:BWX39_RS03015
uniprot id: A0A1P8JD64
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1122984:BWX39 RS11525
gene id: 1122984:BWX39_RS11525
uniprot id: A0A1P8JHS9
names: Similarity
messages: Belongs to the RutC family.

1122984:BWX39 RS08420
gene id: 1122984:BWX39_RS08420
uniprot id: A0A1P8JFZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1122984:BWX39 RS06430
gene id: 1122984:BWX39_RS06430
uniprot id: A0A1P8JEW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

1122984:BWX39 RS03270
gene id: 1122984:BWX39_RS03270
uniprot id: A0A1P8JDD3
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

1122984:BWX39 RS11685
gene id: 1122984:BWX39_RS11685
uniprot id: A0A1P8JGC9
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS11425
gene id: 1122984:BWX39_RS11425
uniprot id: A0A1P8JHQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1122984:BWX39 RS02895
gene id: 1122984:BWX39_RS02895
uniprot id: A0A1P8JD48
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS01795
gene id: 1122984:BWX39_RS01795
uniprot id: A0A1P8JCL3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1122984:BWX39 RS05280
gene id: 1122984:BWX39_RS05280
uniprot id: A0A1P8JEC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1122984:BWX39 RS02235
gene id: 1122984:BWX39_RS02235
uniprot id: A0A1P8JCT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1122984:BWX39 RS07055
gene id: 1122984:BWX39_RS07055
uniprot id: A0A1P8JFB0
names: Similarity
messages: Belongs to the fabD family.

1122984:BWX39 RS06365
gene id: 1122984:BWX39_RS06365
uniprot id: A0A1P8JEW8
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS02710
gene id: 1122984:BWX39_RS02710
uniprot id: A0A1P8JD32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1122984:BWX39 RS08415
gene id: 1122984:BWX39_RS08415
uniprot id: A0A1P8JFY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1122984:BWX39 RS09080
gene id: 1122984:BWX39_RS09080
uniprot id: A0A1P8JGK1
names: Similarity
messages: Belongs to the peptidase C10 family.

1122984:BWX39 RS05375
gene id: 1122984:BWX39_RS05375
uniprot id: A0A1P8JEC8
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

1122984:BWX39 RS04380
gene id: 1122984:BWX39_RS04380
uniprot id: A0A1P8JDX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1122984:BWX39 RS04100
gene id: 1122984:BWX39_RS04100
uniprot id: A0A1P8JDR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1122984:BWX39 RS06485
gene id: 1122984:BWX39_RS06485
uniprot id: A0A1P8JEX2
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

1122984:BWX39 RS09585
gene id: 1122984:BWX39_RS09585
uniprot id: A0A1P8JGU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1122984:BWX39 RS01430
gene id: 1122984:BWX39_RS01430
uniprot id: A0A1P8JCE9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1122984:BWX39 RS01305
gene id: 1122984:BWX39_RS01305
uniprot id: A0A1P8JG18
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS08285
gene id: 1122984:BWX39_RS08285
uniprot id: A0A1P8JFU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1122984:BWX39 RS08675
gene id: 1122984:BWX39_RS08675
uniprot id: A0A1P8JGE7
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS05390
gene id: 1122984:BWX39_RS05390
uniprot id: A0A1P8JED7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 51 family.
messages: Cell membrane
messages: Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.

1122984:BWX39 RS03555
gene id: 1122984:BWX39_RS03555
uniprot id: A0A1P8JDI4
names: Similarity
messages: Belongs to the MreC family.

1122984:BWX39 RS05920
gene id: 1122984:BWX39_RS05920
uniprot id: A0A1P8JEP0
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1122984:BWX39 RS08365
gene id: 1122984:BWX39_RS08365
uniprot id: A0A1P8JFY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1122984:BWX39 RS09715
gene id: 1122984:BWX39_RS09715
uniprot id: A0A1P8JGV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

1122984:BWX39 RS00640
gene id: 1122984:BWX39_RS00640
uniprot id: A0A1P8JBZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

1122984:BWX39 RS02835
gene id: 1122984:BWX39_RS02835
uniprot id: A0A1P8JD39
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

1122984:BWX39 RS02475
gene id: 1122984:BWX39_RS02475
uniprot id: A0A1P8JCZ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

1122984:BWX39 RS00795
gene id: 1122984:BWX39_RS00795
uniprot id: A0A1P8JC28
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1122984:BWX39 RS02410
gene id: 1122984:BWX39_RS02410
uniprot id: A0A1P8JCW9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.

1122984:BWX39 RS10240
gene id: 1122984:BWX39_RS10240
uniprot id: A0A1P8JH56
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1122984:BWX39 RS02395
gene id: 1122984:BWX39_RS02395
uniprot id: A0A1P8JCY8
names: Similarity
messages: Belongs to the glutamine synthetase family.

1122984:BWX39 RS03760
gene id: 1122984:BWX39_RS03760
uniprot id: A0A1P8JDM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

1122984:BWX39 RS07025
gene id: 1122984:BWX39_RS07025
uniprot id: A0A1P8JF78
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS04395
gene id: 1122984:BWX39_RS04395
uniprot id: A0A1P8JDX7
names: Similarity
messages: Belongs to the peptidase S49 family.

1122984:BWX39 RS10745
gene id: 1122984:BWX39_RS10745
uniprot id: A0A1P8JHC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

1122984:BWX39 RS03580
gene id: 1122984:BWX39_RS03580
uniprot id: A0A1P8JDJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1122984:BWX39 RS07715
gene id: 1122984:BWX39_RS07715
uniprot id: A0A1P8JGB6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1122984:BWX39 RS03205
gene id: 1122984:BWX39_RS03205
uniprot id: A0A1P8JDB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1122984:BWX39 RS00010
gene id: 1122984:BWX39_RS00010
uniprot id: A0A1P8JGD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1122984:BWX39 RS06180
gene id: 1122984:BWX39_RS06180
uniprot id: A0A1P8JEV4
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

1122984:BWX39 RS05635
gene id: 1122984:BWX39_RS05635
uniprot id: A0A1P8JEH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

1122984:BWX39 RS08070
gene id: 1122984:BWX39_RS08070
uniprot id: A0A1P8JFR4
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

1122984:BWX39 RS10430
gene id: 1122984:BWX39_RS10430
uniprot id: A0A1P8JH68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1122984:BWX39 RS07980
gene id: 1122984:BWX39_RS07980
uniprot id: A0A1P8JFQ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

1122984:BWX39 RS01010
gene id: 1122984:BWX39_RS01010
uniprot id: A0A1P8JG21
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS04550
gene id: 1122984:BWX39_RS04550
uniprot id: A0A1P8JE02
names: Similarity
messages: Belongs to the peptidase S9C family.

1122984:BWX39 RS01905
gene id: 1122984:BWX39_RS01905
uniprot id: A0A1P8JCM9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1122984:BWX39 RS03930
gene id: 1122984:BWX39_RS03930
uniprot id: A0A1P8JDN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

1122984:BWX39 RS09770
gene id: 1122984:BWX39_RS09770
uniprot id: A0A1P8JHX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

1122984:BWX39 RS07535
gene id: 1122984:BWX39_RS07535
uniprot id: A0A1P8JFH7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1122984:BWX39 RS02745
gene id: 1122984:BWX39_RS02745
uniprot id: A0A1P8JD45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1122984:BWX39 RS03845
gene id: 1122984:BWX39_RS03845
uniprot id: A0A1P8JDL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1122984:BWX39 RS01855
gene id: 1122984:BWX39_RS01855
uniprot id: A0A1P8JCL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1122984:BWX39 RS02350
gene id: 1122984:BWX39_RS02350
uniprot id: A0A1P8JCV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1122984:BWX39 RS03915
gene id: 1122984:BWX39_RS03915
uniprot id: A0A1P8JDN0
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1122984:BWX39 RS03560
gene id: 1122984:BWX39_RS03560
uniprot id: A0A1P8JDG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

1122984:BWX39 RS05730
gene id: 1122984:BWX39_RS05730
uniprot id: A0A1P8JEL7
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS01060
gene id: 1122984:BWX39_RS01060
uniprot id: A0A1P8JC79
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1122984:BWX39 RS09930
gene id: 1122984:BWX39_RS09930
uniprot id: A0A1P8JGZ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1122984:BWX39 RS10715
gene id: 1122984:BWX39_RS10715
uniprot id: A0A1P8JHD9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1122984:BWX39 RS08885
gene id: 1122984:BWX39_RS08885
uniprot id: A0A1P8JGH4
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS04075
gene id: 1122984:BWX39_RS04075
uniprot id: A0A1P8JDR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1122984:BWX39 RS02360
gene id: 1122984:BWX39_RS02360
uniprot id: A0A1P8JG29
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS07155
gene id: 1122984:BWX39_RS07155
uniprot id: A0A1P8JFB9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1122984:BWX39 RS00405
gene id: 1122984:BWX39_RS00405
uniprot id: A0A1P8JC03
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

1122984:BWX39 RS00170
gene id: 1122984:BWX39_RS00170
uniprot id: A0A1P8JBS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

1122984:BWX39 RS08105
gene id: 1122984:BWX39_RS08105
uniprot id: A0A1P8JFS1
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1122984:BWX39 RS10100
gene id: 1122984:BWX39_RS10100
uniprot id: A0A1P8JH34
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

1122984:BWX39 RS05155
gene id: 1122984:BWX39_RS05155
uniprot id: A0A1P8JEA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

1122984:BWX39 RS07410
gene id: 1122984:BWX39_RS07410
uniprot id: A0A1P8JFE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1122984:BWX39 RS06560
gene id: 1122984:BWX39_RS06560
uniprot id: A0A1P8JF13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
messages: Membrane

1122984:BWX39 RS08355
gene id: 1122984:BWX39_RS08355
uniprot id: A0A1P8JFW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1122984:BWX39 RS09610
gene id: 1122984:BWX39_RS09610
uniprot id: A0A1P8JGV4
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS01300
gene id: 1122984:BWX39_RS01300
uniprot id: A0A1P8JCF6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1122984:BWX39 RS02355
gene id: 1122984:BWX39_RS02355
uniprot id: A0A1P8JCV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1122984:BWX39 RS01050
gene id: 1122984:BWX39_RS01050
uniprot id: A0A1P8JC78
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1122984:BWX39 RS04900
gene id: 1122984:BWX39_RS04900
uniprot id: A0A1P8JE67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1122984:BWX39 RS08910
gene id: 1122984:BWX39_RS08910
uniprot id: A0A1P8JGH0
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS06325
gene id: 1122984:BWX39_RS06325
uniprot id: A0A1P8JEU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1122984:BWX39 RS05610
gene id: 1122984:BWX39_RS05610
uniprot id: A0A1P8JEG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

1122984:BWX39 RS06190
gene id: 1122984:BWX39_RS06190
uniprot id: A0A1P8JET4
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS03950
gene id: 1122984:BWX39_RS03950
uniprot id: A0A1P8JDP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1122984:BWX39 RS11265
gene id: 1122984:BWX39_RS11265
uniprot id: A0A1P8JHM5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1122984:BWX39 RS03960
gene id: 1122984:BWX39_RS03960
uniprot id: A0A1P8JDP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1122984:BWX39 RS07965
gene id: 1122984:BWX39_RS07965
uniprot id: A0A1P8JFP2
names: Similarity
messages: Belongs to the peptidase C1 family.

1122984:BWX39 RS08045
gene id: 1122984:BWX39_RS08045
uniprot id: A0A1P8JFS9
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

1122984:BWX39 RS10195
gene id: 1122984:BWX39_RS10195
uniprot id: A0A1P8JH52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

1122984:BWX39 RS04740
gene id: 1122984:BWX39_RS04740
uniprot id: A0A1P8JE39
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS09255
gene id: 1122984:BWX39_RS09255
uniprot id: A0A1P8JGN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1122984:BWX39 RS02785
gene id: 1122984:BWX39_RS02785
uniprot id: A0A1P8JD29
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1122984:BWX39 RS10130
gene id: 1122984:BWX39_RS10130
uniprot id: A0A1P8JHY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1122984:BWX39 RS04225
gene id: 1122984:BWX39_RS04225
uniprot id: A0A1P8JDU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

1122984:BWX39 RS06250
gene id: 1122984:BWX39_RS06250
uniprot id: A0A1P8JEV6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

1122984:BWX39 RS04880
gene id: 1122984:BWX39_RS04880
uniprot id: A0A1P8JE45
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

1122984:BWX39 RS01650
gene id: 1122984:BWX39_RS01650
uniprot id: A0A1P8JCI4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

1122984:BWX39 RS00600
gene id: 1122984:BWX39_RS00600
uniprot id: A0A1P8JBZ1
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1122984:BWX39 RS01210
gene id: 1122984:BWX39_RS01210
uniprot id: A0A1P8JCA4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

1122984:BWX39 RS02345
gene id: 1122984:BWX39_RS02345
uniprot id: A0A1P8JCV3
names: Subcellular Location Annotation
messages: Membrane

1122984:BWX39 RS09920
gene id: 1122984:BWX39_RS09920
uniprot id: A0A1P8JH04
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1122984:BWX39 RS02490
gene id: 1122984:BWX39_RS02490
uniprot id: A0A1P8JCX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1122984:BWX39 RS02210
gene id: 1122984:BWX39_RS02210
uniprot id: A0A1P8JG40
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

1122984:BWX39 RS06000
gene id: 1122984:BWX39_RS06000
uniprot id: A0A1P8JEQ5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1122984:BWX39 RS04525
gene id: 1122984:BWX39_RS04525
uniprot id: A0A1P8JDZ2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1122984:BWX39 RS08080
gene id: 1122984:BWX39_RS08080
uniprot id: A0A1P8JGB9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1122984:BWX39 RS04520
gene id: 1122984:BWX39_RS04520
uniprot id: A0A1P8JDY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1122984:BWX39 RS08065
gene id: 1122984:BWX39_RS08065
uniprot id: A0A1P8JFR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1122984:BWX39 RS01375
gene id: 1122984:BWX39_RS01375
uniprot id: A0A1P8JCD4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1122984:BWX39 RS06960
gene id: 1122984:BWX39_RS06960
uniprot id: A0A1P8JF64
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1122984:BWX39 RS06735
gene id: 1122984:BWX39_RS06735
uniprot id: A0A1P8JF69
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1122984:BWX39 RS02380
gene id: 1122984:BWX39_RS02380
uniprot id: A0A1P8JCV4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1122984:BWX39 RS10335
gene id: 1122984:BWX39_RS10335
uniprot id: A0A1P8JH62
names: Similarity
messages: Belongs to the class-I fumarase family.