1121353:H924 RS07735
gene id: 1121353:H924_RS07735
uniprot id: M1ULK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1121353:H924 RS05585
gene id: 1121353:H924_RS05585
uniprot id: M1UEP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1121353:H924 RS11645
gene id: 1121353:H924_RS11645
uniprot id: M1UVX0
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS10260
gene id: 1121353:H924_RS10260
uniprot id: M1UMP2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1121353:H924 RS01165
gene id: 1121353:H924_RS01165
uniprot id: M1UIU4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1121353:H924 RS01930
gene id: 1121353:H924_RS01930
uniprot id: M1UD34
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS10500
gene id: 1121353:H924_RS10500
uniprot id: M1UVL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Fes family.
messages: Cytoplasm

1121353:H924 RS12440
gene id: 1121353:H924_RS12440
uniprot id: M1TUK4
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

1121353:H924 RS09440
gene id: 1121353:H924_RS09440
uniprot id: M1UMB9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1121353:H924 RS01060
gene id: 1121353:H924_RS01060
uniprot id: M1UCQ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

1121353:H924 RS03210
gene id: 1121353:H924_RS03210
uniprot id: M1UJR5
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1121353:H924 RS12175
gene id: 1121353:H924_RS12175
uniprot id: M1UW38
names: Similarity
messages: Belongs to the AccD/PCCB family.

1121353:H924 RS12070
gene id: 1121353:H924_RS12070
uniprot id: M1UHF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

1121353:H924 RS09845
gene id: 1121353:H924_RS09845
uniprot id: M1TT38
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1121353:H924 RS02385
gene id: 1121353:H924_RS02385
uniprot id: M1US69
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1121353:H924 RS05450
gene id: 1121353:H924_RS05450
uniprot id: M1UEM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

1121353:H924 RS09840
gene id: 1121353:H924_RS09840
uniprot id: M1UGI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Membrane

1121353:H924 RS07030
gene id: 1121353:H924_RS07030
uniprot id: M1UF97
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

1121353:H924 RS02515
gene id: 1121353:H924_RS02515
uniprot id: M1US97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1121353:H924 RS11505
gene id: 1121353:H924_RS11505
uniprot id: M1TTZ2
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS07500
gene id: 1121353:H924_RS07500
uniprot id: M1UZ41
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS03930
gene id: 1121353:H924_RS03930
uniprot id: M1UDZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1121353:H924 RS00025
gene id: 1121353:H924_RS00025
uniprot id: M1UIF9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1121353:H924 RS08920
gene id: 1121353:H924_RS08920
uniprot id: M1TSH2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS09215
gene id: 1121353:H924_RS09215
uniprot id: M1UV46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1121353:H924 RS07670
gene id: 1121353:H924_RS07670
uniprot id: M1UUJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1121353:H924 RS05470
gene id: 1121353:H924_RS05470
uniprot id: M1UKP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

1121353:H924 RS09735
gene id: 1121353:H924_RS09735
uniprot id: M1UMG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1121353:H924 RS05320
gene id: 1121353:H924_RS05320
uniprot id: M1UKM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1121353:H924 RS11335
gene id: 1121353:H924_RS11335
uniprot id: M1TTW3
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

1121353:H924 RS06965
gene id: 1121353:H924_RS06965
uniprot id: M1UYX1
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS03160
gene id: 1121353:H924_RS03160
uniprot id: M1UJQ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS07065
gene id: 1121353:H924_RS07065
uniprot id: M1UFA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS10375
gene id: 1121353:H924_RS10375
uniprot id: M1V008
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1121353:H924 RS09340
gene id: 1121353:H924_RS09340
uniprot id: M1UZP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

1121353:H924 RS02865
gene id: 1121353:H924_RS02865
uniprot id: M1TNY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.

1121353:H924 RS04220
gene id: 1121353:H924_RS04220
uniprot id: M1UK39
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

1121353:H924 RS12615
gene id: 1121353:H924_RS12615
uniprot id: M1UWA4
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1121353:H924 RS02060
gene id: 1121353:H924_RS02060
uniprot id: M1TNF9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

1121353:H924 RS12640
gene id: 1121353:H924_RS12640
uniprot id: M1UWA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

1121353:H924 RS04575
gene id: 1121353:H924_RS04575
uniprot id: M1UY58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1121353:H924 RS04375
gene id: 1121353:H924_RS04375
uniprot id: M1TPM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

1121353:H924 RS08740
gene id: 1121353:H924_RS08740
uniprot id: M1UG03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

1121353:H924 RS00305
gene id: 1121353:H924_RS00305
uniprot id: M1UWU0
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

1121353:H924 RS09175
gene id: 1121353:H924_RS09175
uniprot id: M1UM76
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS05675
gene id: 1121353:H924_RS05675
uniprot id: M1UYI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

1121353:H924 RS01755
gene id: 1121353:H924_RS01755
uniprot id: M1UJ25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1121353:H924 RS09870
gene id: 1121353:H924_RS09870
uniprot id: M1TT45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1121353:H924 RS12865
gene id: 1121353:H924_RS12865
uniprot id: M1TUW2
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS01850
gene id: 1121353:H924_RS01850
uniprot id: M1UX96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1121353:H924 RS12150
gene id: 1121353:H924_RS12150
uniprot id: M1UW36
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

1121353:H924 RS12625
gene id: 1121353:H924_RS12625
uniprot id: M1UNU5
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS07940
gene id: 1121353:H924_RS07940
uniprot id: M1UFQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1121353:H924 RS05780
gene id: 1121353:H924_RS05780
uniprot id: M1UES1
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

1121353:H924 RS07970
gene id: 1121353:H924_RS07970
uniprot id: M1TRZ8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.
messages: Cell membrane
messages: Contains a di-nuclear catalytic Mg(2+) center.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1121353:H924 RS11100
gene id: 1121353:H924_RS11100
uniprot id: M1UGZ9
names: Similarity
messages: Belongs to the DSD1 family.

1121353:H924 RS01890
gene id: 1121353:H924_RS01890
uniprot id: M1URX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1121353:H924 RS08345
gene id: 1121353:H924_RS08345
uniprot id: M1UZD3
names: Similarity
messages: Belongs to the PspA/IM30 family.

1121353:H924 RS00155
gene id: 1121353:H924_RS00155
uniprot id: M1UCE2
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS10210
gene id: 1121353:H924_RS10210
uniprot id: M1UMN6
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

1121353:H924 RS08230
gene id: 1121353:H924_RS08230
uniprot id: M1TS41
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1121353:H924 RS10920
gene id: 1121353:H924_RS10920
uniprot id: M1V049
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1121353:H924 RS06345
gene id: 1121353:H924_RS06345
uniprot id: M1UTX6
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS10440
gene id: 1121353:H924_RS10440
uniprot id: M1UMR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1121353:H924 RS10300
gene id: 1121353:H924_RS10300
uniprot id: M1UMP5
names: Similarity
messages: Belongs to the peptidase M1 family.

1121353:H924 RS11250
gene id: 1121353:H924_RS11250
uniprot id: M1UN40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS09365
gene id: 1121353:H924_RS09365
uniprot id: M1UZP9
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

1121353:H924 RS07900
gene id: 1121353:H924_RS07900
uniprot id: M1UUM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1121353:H924 RS05655
gene id: 1121353:H924_RS05655
uniprot id: M1UKS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1121353:H924 RS04335
gene id: 1121353:H924_RS04335
uniprot id: M1UY31
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

1121353:H924 RS11760
gene id: 1121353:H924_RS11760
uniprot id: M1UHA1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1121353:H924 RS07570
gene id: 1121353:H924_RS07570
uniprot id: M1UUI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1121353:H924 RS08105
gene id: 1121353:H924_RS08105
uniprot id: M1TS17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1121353:H924 RS05605
gene id: 1121353:H924_RS05605
uniprot id: M1UKR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1121353:H924 RS01370
gene id: 1121353:H924_RS01370
uniprot id: M1UCU5
names: Subcellular Location Annotation
messages: Cytoplasm

1121353:H924 RS08520
gene id: 1121353:H924_RS08520
uniprot id: M1UZF0
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

1121353:H924 RS08155
gene id: 1121353:H924_RS08155
uniprot id: M1TS27
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1121353:H924 RS05290
gene id: 1121353:H924_RS05290
uniprot id: M1UYF0
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

1121353:H924 RS08690
gene id: 1121353:H924_RS08690
uniprot id: M1TSC6
names: Similarity
messages: Belongs to the UPF0102 family.

1121353:H924 RS09745
gene id: 1121353:H924_RS09745
uniprot id: M1TT12
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

1121353:H924 RS02520
gene id: 1121353:H924_RS02520
uniprot id: M1UXJ5
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1121353:H924 RS01090
gene id: 1121353:H924_RS01090
uniprot id: M1UIT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1121353:H924 RS10780
gene id: 1121353:H924_RS10780
uniprot id: M1V037
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1121353:H924 RS01345
gene id: 1121353:H924_RS01345
uniprot id: M1UCU3
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS00580
gene id: 1121353:H924_RS00580
uniprot id: M1UWW1
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS06515
gene id: 1121353:H924_RS06515
uniprot id: M1TQY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1121353:H924 RS08530
gene id: 1121353:H924_RS08530
uniprot id: M1UFX1
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1121353:H924 RS06445
gene id: 1121353:H924_RS06445
uniprot id: M1UTZ2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1121353:H924 RS11230
gene id: 1121353:H924_RS11230
uniprot id: M1UH17
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

1121353:H924 RS03355
gene id: 1121353:H924_RS03355
uniprot id: M1USK6
names: Similarity
messages: Belongs to the AHA1 family.

1121353:H924 RS06930
gene id: 1121353:H924_RS06930
uniprot id: M1TR70
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic ubiquitin-like protein family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
messages: Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.
messages: The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.

1121353:H924 RS00115
gene id: 1121353:H924_RS00115
uniprot id: M1UR93
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

1121353:H924 RS02610
gene id: 1121353:H924_RS02610
uniprot id: M1TNU5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1121353:H924 RS02630
gene id: 1121353:H924_RS02630
uniprot id: M1UDG7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1121353:H924 RS08635
gene id: 1121353:H924_RS08635
uniprot id: M1UFY7
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

1121353:H924 RS05300
gene id: 1121353:H924_RS05300
uniprot id: M1UEL1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS05620
gene id: 1121353:H924_RS05620
uniprot id: M1UTN4
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS05740
gene id: 1121353:H924_RS05740
uniprot id: M1TQF8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1121353:H924 RS07705
gene id: 1121353:H924_RS07705
uniprot id: M1ULK5
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

1121353:H924 RS03635
gene id: 1121353:H924_RS03635
uniprot id: M1UXV3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1121353:H924 RS12825
gene id: 1121353:H924_RS12825
uniprot id: M1V0T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1121353:H924 RS10815
gene id: 1121353:H924_RS10815
uniprot id: M1UGW8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS04680
gene id: 1121353:H924_RS04680
uniprot id: M1UY72
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1121353:H924 RS05715
gene id: 1121353:H924_RS05715
uniprot id: M1TQF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.
messages: Homodimer.
messages: Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.

1121353:H924 RS02575
gene id: 1121353:H924_RS02575
uniprot id: M1UJH9
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS03220
gene id: 1121353:H924_RS03220
uniprot id: M1TP35
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1121353:H924 RS11315
gene id: 1121353:H924_RS11315
uniprot id: M1UVT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS11640
gene id: 1121353:H924_RS11640
uniprot id: M1TU17
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1121353:H924 RS04955
gene id: 1121353:H924_RS04955
uniprot id: M1UYA8
names: Similarity
messages: Belongs to the citrate synthase family.

1121353:H924 RS11000
gene id: 1121353:H924_RS11000
uniprot id: M1UN00
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1121353:H924 RS00780
gene id: 1121353:H924_RS00780
uniprot id: M1UIP8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1121353:H924 RS05795
gene id: 1121353:H924_RS05795
uniprot id: M1UYJ5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1121353:H924 RS10695
gene id: 1121353:H924_RS10695
uniprot id: M1V030
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1121353:H924 RS07040
gene id: 1121353:H924_RS07040
uniprot id: M1UU86
names: Similarity
messages: Belongs to the UPF0098 family.

1121353:H924 RS07580
gene id: 1121353:H924_RS07580
uniprot id: M1ULI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm

1121353:H924 RS06490
gene id: 1121353:H924_RS06490
uniprot id: M1TQX8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1121353:H924 RS11320
gene id: 1121353:H924_RS11320
uniprot id: M1V090
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1121353:H924 RS06110
gene id: 1121353:H924_RS06110
uniprot id: M1UEW6
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

1121353:H924 RS01650
gene id: 1121353:H924_RS01650
uniprot id: M1URT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1121353:H924 RS12595
gene id: 1121353:H924_RS12595
uniprot id: M1V0Q7
names: Similarity
messages: Belongs to the thioredoxin family.

1121353:H924 RS07790
gene id: 1121353:H924_RS07790
uniprot id: M1UFN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

1121353:H924 RS02490
gene id: 1121353:H924_RS02490
uniprot id: M1US93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1121353:H924 RS06745
gene id: 1121353:H924_RS06745
uniprot id: M1UL60
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS01910
gene id: 1121353:H924_RS01910
uniprot id: M1TNC1
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1121353:H924 RS03090
gene id: 1121353:H924_RS03090
uniprot id: M1UDM4
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1121353:H924 RS10410
gene id: 1121353:H924_RS10410
uniprot id: M1UGR6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1121353:H924 RS06280
gene id: 1121353:H924_RS06280
uniprot id: M1UL01
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

1121353:H924 RS06645
gene id: 1121353:H924_RS06645
uniprot id: M1UF38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1121353:H924 RS09700
gene id: 1121353:H924_RS09700
uniprot id: M1UVB2
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS01380
gene id: 1121353:H924_RS01380
uniprot id: M1URQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

1121353:H924 RS10495
gene id: 1121353:H924_RS10495
uniprot id: M1TTI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

1121353:H924 RS06950
gene id: 1121353:H924_RS06950
uniprot id: M1UF86
names: Similarity
messages: Belongs to the peptidase M18 family.

1121353:H924 RS11975
gene id: 1121353:H924_RS11975
uniprot id: M1UW15
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

1121353:H924 RS09325
gene id: 1121353:H924_RS09325
uniprot id: M1UG94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Cell membrane
messages: Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.

1121353:H924 RS05660
gene id: 1121353:H924_RS05660
uniprot id: M1UEQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1121353:H924 RS00665
gene id: 1121353:H924_RS00665
uniprot id: M1UCK3
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS00135
gene id: 1121353:H924_RS00135
uniprot id: M1TME0
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS11905
gene id: 1121353:H924_RS11905
uniprot id: M1V0H0
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1121353:H924 RS10925
gene id: 1121353:H924_RS10925
uniprot id: M1UMY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1121353:H924 RS03655
gene id: 1121353:H924_RS03655
uniprot id: M1USQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

1121353:H924 RS05145
gene id: 1121353:H924_RS05145
uniprot id: M1UYD7
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1121353:H924 RS11140
gene id: 1121353:H924_RS11140
uniprot id: M1V072
names: Similarity
messages: Belongs to the EfeM/EfeO family.

1121353:H924 RS02635
gene id: 1121353:H924_RS02635
uniprot id: M1TNU9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1121353:H924 RS03590
gene id: 1121353:H924_RS03590
uniprot id: M1UDU3
names: Similarity
messages: Belongs to the peptidase S16 family.

1121353:H924 RS10050
gene id: 1121353:H924_RS10050
uniprot id: M1UVG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1121353:H924 RS06800
gene id: 1121353:H924_RS06800
uniprot id: M1UF59
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS07870
gene id: 1121353:H924_RS07870
uniprot id: M1TRX9
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1121353:H924 RS05710
gene id: 1121353:H924_RS05710
uniprot id: M1UER0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

1121353:H924 RS10145
gene id: 1121353:H924_RS10145
uniprot id: M1TTD6
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

1121353:H924 RS05980
gene id: 1121353:H924_RS05980
uniprot id: M1UEV1
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

1121353:H924 RS13985
gene id: 1121353:H924_RS13985
uniprot id: M1TTM4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1121353:H924 RS02535
gene id: 1121353:H924_RS02535
uniprot id: M1TNT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1121353:H924 RS02035
gene id: 1121353:H924_RS02035
uniprot id: M1TNF3
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

1121353:H924 RS11350
gene id: 1121353:H924_RS11350
uniprot id: M1UN56
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1121353:H924 RS13155
gene id: 1121353:H924_RS13155
uniprot id: M1UWH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

1121353:H924 RS09015
gene id: 1121353:H924_RS09015
uniprot id: M1TSJ1
names: Similarity
messages: Belongs to the HSP15 family.

1121353:H924 RS07750
gene id: 1121353:H924_RS07750
uniprot id: M1UUK9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

1121353:H924 RS00905
gene id: 1121353:H924_RS00905
uniprot id: M1UIR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 85 family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS08940
gene id: 1121353:H924_RS08940
uniprot id: M1UG34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1121353:H924 RS05645
gene id: 1121353:H924_RS05645
uniprot id: M1UTN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1121353:H924 RS11945
gene id: 1121353:H924_RS11945
uniprot id: M1TU86
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

1121353:H924 RS03855
gene id: 1121353:H924_RS03855
uniprot id: M1UST2
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS00120
gene id: 1121353:H924_RS00120
uniprot id: M1UWS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS02735
gene id: 1121353:H924_RS02735
uniprot id: M1TNW6
names: Similarity
messages: Belongs to the WXG100 family.

1121353:H924 RS04790
gene id: 1121353:H924_RS04790
uniprot id: M1UEC9
names: Similarity
messages: Belongs to the non-flavoprotein flavin reductase family.

1121353:H924 RS02475
gene id: 1121353:H924_RS02475
uniprot id: M1UJG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1121353:H924 RS06165
gene id: 1121353:H924_RS06165
uniprot id: M1UTV0
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

1121353:H924 RS09715
gene id: 1121353:H924_RS09715
uniprot id: M1UGG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1121353:H924 RS09445
gene id: 1121353:H924_RS09445
uniprot id: M1UGB7
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1121353:H924 RS05120
gene id: 1121353:H924_RS05120
uniprot id: M1UYD5
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS04265
gene id: 1121353:H924_RS04265
uniprot id: M1UK47
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1121353:H924 RS10725
gene id: 1121353:H924_RS10725
uniprot id: M1UMW0
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

1121353:H924 RS10645
gene id: 1121353:H924_RS10645
uniprot id: M1V026
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS11460
gene id: 1121353:H924_RS11460
uniprot id: M1UVU8
names: Similarity
messages: Belongs to the peptidase S13 family.

1121353:H924 RS06995
gene id: 1121353:H924_RS06995
uniprot id: M1UL94
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

1121353:H924 RS09970
gene id: 1121353:H924_RS09970
uniprot id: M1UVF3
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS12690
gene id: 1121353:H924_RS12690
uniprot id: M1UWC3
names: Similarity
messages: Belongs to the FPG family.

1121353:H924 RS05600
gene id: 1121353:H924_RS05600
uniprot id: M1UYH7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS08480
gene id: 1121353:H924_RS08480
uniprot id: M1UFW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1121353:H924 RS07875
gene id: 1121353:H924_RS07875
uniprot id: M1UUM3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1121353:H924 RS01745
gene id: 1121353:H924_RS01745
uniprot id: M1URV5
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS07945
gene id: 1121353:H924_RS07945
uniprot id: M1TRZ3
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

1121353:H924 RS06980
gene id: 1121353:H924_RS06980
uniprot id: M1TR82
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1121353:H924 RS08065
gene id: 1121353:H924_RS08065
uniprot id: M1UZA6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

1121353:H924 RS06525
gene id: 1121353:H924_RS06525
uniprot id: M1UYR6
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS02445
gene id: 1121353:H924_RS02445
uniprot id: M1UXI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1121353:H924 RS07820
gene id: 1121353:H924_RS07820
uniprot id: M1TRW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

1121353:H924 RS08250
gene id: 1121353:H924_RS08250
uniprot id: M1UFT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1121353:H924 RS01155
gene id: 1121353:H924_RS01155
uniprot id: M1URM0
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

1121353:H924 RS03660
gene id: 1121353:H924_RS03660
uniprot id: M1UXV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1121353:H924 RS03620
gene id: 1121353:H924_RS03620
uniprot id: M1TPA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

1121353:H924 RS10965
gene id: 1121353:H924_RS10965
uniprot id: M1UVQ2
names: Caution
names: Similarity
messages: Belongs to the nitrobindin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lacks the conserved His residue that binds heme iron in the nitrobindin family.

1121353:H924 RS02415
gene id: 1121353:H924_RS02415
uniprot id: M1UXH7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1121353:H924 RS03125
gene id: 1121353:H924_RS03125
uniprot id: M1USH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1121353:H924 RS07730
gene id: 1121353:H924_RS07730
uniprot id: M1UZ75
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

1121353:H924 RS04215
gene id: 1121353:H924_RS04215
uniprot id: M1UY16
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1121353:H924 RS02650
gene id: 1121353:H924_RS02650
uniprot id: M1UJI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1121353:H924 RS11570
gene id: 1121353:H924_RS11570
uniprot id: M1TU02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

1121353:H924 RS13010
gene id: 1121353:H924_RS13010
uniprot id: M1V0V5
names: Similarity
messages: Belongs to the oxoprolinase family.

1121353:H924 RS07520
gene id: 1121353:H924_RS07520
uniprot id: M1UUH4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

1121353:H924 RS09155
gene id: 1121353:H924_RS09155
uniprot id: M1UG68
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

1121353:H924 RS08950
gene id: 1121353:H924_RS08950
uniprot id: M1UUZ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1121353:H924 RS00010
gene id: 1121353:H924_RS00010
uniprot id: M1TMC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1121353:H924 RS02940
gene id: 1121353:H924_RS02940
uniprot id: M1TNZ4
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

1121353:H924 RS10285
gene id: 1121353:H924_RS10285
uniprot id: M1UVJ4
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1121353:H924 RS07650
gene id: 1121353:H924_RS07650
uniprot id: M1UZ68
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS11580
gene id: 1121353:H924_RS11580
uniprot id: M1UNA0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

1121353:H924 RS08830
gene id: 1121353:H924_RS08830
uniprot id: M1UZH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS07930
gene id: 1121353:H924_RS07930
uniprot id: M1UZ95
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1121353:H924 RS11650
gene id: 1121353:H924_RS11650
uniprot id: M1V0D9
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS11780
gene id: 1121353:H924_RS11780
uniprot id: M1UND8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

1121353:H924 RS05205
gene id: 1121353:H924_RS05205
uniprot id: M1UEK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1121353:H924 RS06435
gene id: 1121353:H924_RS06435
uniprot id: M1UF11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

1121353:H924 RS05085
gene id: 1121353:H924_RS05085
uniprot id: M1TQ27
names: Similarity
messages: Belongs to the AAE transporter (TC 2.A.81) family.

1121353:H924 RS10110
gene id: 1121353:H924_RS10110
uniprot id: M1UMM5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

1121353:H924 RS08330
gene id: 1121353:H924_RS08330
uniprot id: M1UFU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

1121353:H924 RS05870
gene id: 1121353:H924_RS05870
uniprot id: M1UYK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
messages: Membrane

1121353:H924 RS03515
gene id: 1121353:H924_RS03515
uniprot id: M1UDT3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1121353:H924 RS05270
gene id: 1121353:H924_RS05270
uniprot id: M1UYE8
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

1121353:H924 RS05440
gene id: 1121353:H924_RS05440
uniprot id: M1UYG4
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS01985
gene id: 1121353:H924_RS01985
uniprot id: M1TNE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

1121353:H924 RS11295
gene id: 1121353:H924_RS11295
uniprot id: M1V087
names: Function
messages: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).

1121353:H924 RS04515
gene id: 1121353:H924_RS04515
uniprot id: M1UE78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1121353:H924 RS08775
gene id: 1121353:H924_RS08775
uniprot id: M1UUX7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1121353:H924 RS01900
gene id: 1121353:H924_RS01900
uniprot id: M1UJ52
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1121353:H924 RS06695
gene id: 1121353:H924_RS06695
uniprot id: M1UL54
names: Similarity
messages: Belongs to the UPF0225 family.

1121353:H924 RS11385
gene id: 1121353:H924_RS11385
uniprot id: M1UVU2
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS01515
gene id: 1121353:H924_RS01515
uniprot id: M1TN31
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1121353:H924 RS04225
gene id: 1121353:H924_RS04225
uniprot id: M1UE30
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1121353:H924 RS04210
gene id: 1121353:H924_RS04210
uniprot id: M1USY8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1121353:H924 RS06390
gene id: 1121353:H924_RS06390
uniprot id: M1TQV5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1121353:H924 RS08925
gene id: 1121353:H924_RS08925
uniprot id: M1UUZ4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1121353:H924 RS09185
gene id: 1121353:H924_RS09185
uniprot id: M1TSM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1121353:H924 RS06285
gene id: 1121353:H924_RS06285
uniprot id: M1UEZ1
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS08905
gene id: 1121353:H924_RS08905
uniprot id: M1UZI9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

1121353:H924 RS02595
gene id: 1121353:H924_RS02595
uniprot id: M1UXK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1121353:H924 RS07555
gene id: 1121353:H924_RS07555
uniprot id: M1ULI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS00355
gene id: 1121353:H924_RS00355
uniprot id: M1UWU4
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS05390
gene id: 1121353:H924_RS05390
uniprot id: M1UYF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Membrane

1121353:H924 RS07985
gene id: 1121353:H924_RS07985
uniprot id: M1ULP7
names: Similarity
messages: Belongs to the DyP-type peroxidase family.

1121353:H924 RS05680
gene id: 1121353:H924_RS05680
uniprot id: M1UKS3
names: Similarity
messages: Belongs to the UPF0045 family.

1121353:H924 RS04890
gene id: 1121353:H924_RS04890
uniprot id: M1UEE5
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

1121353:H924 RS10575
gene id: 1121353:H924_RS10575
uniprot id: M1UGT6
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS10545
gene id: 1121353:H924_RS10545
uniprot id: M1UMT2
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

1121353:H924 RS04440
gene id: 1121353:H924_RS04440
uniprot id: M1UE67
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1121353:H924 RS10785
gene id: 1121353:H924_RS10785
uniprot id: M1UMW9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1121353:H924 RS10380
gene id: 1121353:H924_RS10380
uniprot id: M1UMQ8
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group II subfamily.

1121353:H924 RS03470
gene id: 1121353:H924_RS03470
uniprot id: M1UDS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1121353:H924 RS02540
gene id: 1121353:H924_RS02540
uniprot id: M1USA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1121353:H924 RS09555
gene id: 1121353:H924_RS09555
uniprot id: M1TSX2
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS12910
gene id: 1121353:H924_RS12910
uniprot id: M1UWE8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1121353:H924 RS04505
gene id: 1121353:H924_RS04505
uniprot id: M1UY48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm

1121353:H924 RS11025
gene id: 1121353:H924_RS11025
uniprot id: M1UN05
names: Similarity
messages: Belongs to the glutathione peroxidase family.

1121353:H924 RS04445
gene id: 1121353:H924_RS04445
uniprot id: M1TPN5
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1121353:H924 RS10915
gene id: 1121353:H924_RS10915
uniprot id: M1UVP6
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

1121353:H924 RS04535
gene id: 1121353:H924_RS04535
uniprot id: M1UE81
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS08650
gene id: 1121353:H924_RS08650
uniprot id: M1UZF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1121353:H924 RS05610
gene id: 1121353:H924_RS05610
uniprot id: M1UEP5
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1121353:H924 RS05635
gene id: 1121353:H924_RS05635
uniprot id: M1UEP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1121353:H924 RS10370
gene id: 1121353:H924_RS10370
uniprot id: M1UVK1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1121353:H924 RS11660
gene id: 1121353:H924_RS11660
uniprot id: M1UH86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS09350
gene id: 1121353:H924_RS09350
uniprot id: M1UG98
names: Similarity
messages: Belongs to the asparagine synthetase family.

1121353:H924 RS11055
gene id: 1121353:H924_RS11055
uniprot id: M1UGZ2
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1121353:H924 RS11405
gene id: 1121353:H924_RS11405
uniprot id: M1TTX4
names: Similarity
messages: Belongs to the pantothenate synthetase family.

1121353:H924 RS11330
gene id: 1121353:H924_RS11330
uniprot id: M1UH34
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS13060
gene id: 1121353:H924_RS13060
uniprot id: M1V0V8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1121353:H924 RS09695
gene id: 1121353:H924_RS09695
uniprot id: M1TT01
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

1121353:H924 RS01635
gene id: 1121353:H924_RS01635
uniprot id: M1UJ06
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1121353:H924 RS06325
gene id: 1121353:H924_RS06325
uniprot id: M1UYP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1121353:H924 RS06425
gene id: 1121353:H924_RS06425
uniprot id: M1UYQ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1121353:H924 RS02345
gene id: 1121353:H924_RS02345
uniprot id: M1UXG7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1121353:H924 RS01160
gene id: 1121353:H924_RS01160
uniprot id: M1UX22
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS13105
gene id: 1121353:H924_RS13105
uniprot id: M1V0W2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1121353:H924 RS05815
gene id: 1121353:H924_RS05815
uniprot id: M1UTQ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS05100
gene id: 1121353:H924_RS05100
uniprot id: M1UKJ9
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS01460
gene id: 1121353:H924_RS01460
uniprot id: M1TN21
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1121353:H924 RS12855
gene id: 1121353:H924_RS12855
uniprot id: M1UNZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1121353:H924 RS02440
gene id: 1121353:H924_RS02440
uniprot id: M1US82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1121353:H924 RS04460
gene id: 1121353:H924_RS04460
uniprot id: M1UK80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1121353:H924 RS03285
gene id: 1121353:H924_RS03285
uniprot id: M1UJS5
names: Similarity
messages: Belongs to the AccD/PCCB family.

1121353:H924 RS11450
gene id: 1121353:H924_RS11450
uniprot id: M1UH53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

1121353:H924 RS03165
gene id: 1121353:H924_RS03165
uniprot id: M1UDN3
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS04655
gene id: 1121353:H924_RS04655
uniprot id: M1UY68
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1121353:H924 RS08680
gene id: 1121353:H924_RS08680
uniprot id: M1ULZ6
names: Similarity
messages: Belongs to the DprA/Smf family.

1121353:H924 RS01295
gene id: 1121353:H924_RS01295
uniprot id: M1UCT7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1121353:H924 RS09410
gene id: 1121353:H924_RS09410
uniprot id: M1UV73
names: Similarity
messages: Belongs to the AAE transporter (TC 2.A.81) family.

1121353:H924 RS08555
gene id: 1121353:H924_RS08555
uniprot id: M1ULX7
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1121353:H924 RS03440
gene id: 1121353:H924_RS03440
uniprot id: M1UJU3
names: Caution
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1121353:H924 RS10120
gene id: 1121353:H924_RS10120
uniprot id: M1TTD0
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1121353:H924 RS08855
gene id: 1121353:H924_RS08855
uniprot id: M1UZI1
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1121353:H924 RS01205
gene id: 1121353:H924_RS01205
uniprot id: M1URM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS12245
gene id: 1121353:H924_RS12245
uniprot id: M1TUG0
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

1121353:H924 RS10810
gene id: 1121353:H924_RS10810
uniprot id: M1UMX4
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1121353:H924 RS03245
gene id: 1121353:H924_RS03245
uniprot id: M1TP38
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

1121353:H924 RS12680
gene id: 1121353:H924_RS12680
uniprot id: M1UHR3
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

1121353:H924 RS06755
gene id: 1121353:H924_RS06755
uniprot id: M1TR34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

1121353:H924 RS04970
gene id: 1121353:H924_RS04970
uniprot id: M1TPZ5
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

1121353:H924 RS07805
gene id: 1121353:H924_RS07805
uniprot id: M1UZ83
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

1121353:H924 RS06850
gene id: 1121353:H924_RS06850
uniprot id: M1UF68
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS06530
gene id: 1121353:H924_RS06530
uniprot id: M1UL33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1121353:H924 RS02230
gene id: 1121353:H924_RS02230
uniprot id: M1US40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1121353:H924 RS03435
gene id: 1121353:H924_RS03435
uniprot id: M1UXS8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1121353:H924 RS11380
gene id: 1121353:H924_RS11380
uniprot id: M1TTX1
names: Function
names: Similarity
messages: Belongs to the IMPDH/GMPR family. GuaB1 subfamily.
messages: Involved in the purine-salvage pathway. Catalyzes the NADPH-dependent conversion of GMP to IMP.

1121353:H924 RS03130
gene id: 1121353:H924_RS03130
uniprot id: M1UXQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1121353:H924 RS09990
gene id: 1121353:H924_RS09990
uniprot id: M1TT85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1121353:H924 RS09740
gene id: 1121353:H924_RS09740
uniprot id: M1UGG7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1121353:H924 RS00150
gene id: 1121353:H924_RS00150
uniprot id: M1UIH1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1121353:H924 RS09275
gene id: 1121353:H924_RS09275
uniprot id: M1UM92
names: Cofactor
names: Similarity
messages: Belongs to the class-II DAHP synthase family.
messages: Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.

1121353:H924 RS08700
gene id: 1121353:H924_RS08700
uniprot id: M1UZG3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1121353:H924 RS05995
gene id: 1121353:H924_RS05995
uniprot id: M1UYL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1121353:H924 RS03290
gene id: 1121353:H924_RS03290
uniprot id: M1UDQ2
names: Similarity
messages: Belongs to the AccD/PCCB family.

1121353:H924 RS05400
gene id: 1121353:H924_RS05400
uniprot id: M1UEM4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

1121353:H924 RS02895
gene id: 1121353:H924_RS02895
uniprot id: M1USE7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

1121353:H924 RS00700
gene id: 1121353:H924_RS00700
uniprot id: M1UWX4
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

1121353:H924 RS11105
gene id: 1121353:H924_RS11105
uniprot id: M1TTS4
names: Similarity
messages: Belongs to the TPP enzyme family.

1121353:H924 RS13100
gene id: 1121353:H924_RS13100
uniprot id: M1UWG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

1121353:H924 RS01305
gene id: 1121353:H924_RS01305
uniprot id: M1URP3
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

1121353:H924 RS10130
gene id: 1121353:H924_RS10130
uniprot id: M1UZZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS01925
gene id: 1121353:H924_RS01925
uniprot id: M1UJ58
names: Subcellular Location Annotation
messages: Cell membrane

1121353:H924 RS09650
gene id: 1121353:H924_RS09650
uniprot id: M1UVA5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1121353:H924 RS05580
gene id: 1121353:H924_RS05580
uniprot id: M1UKR1
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

1121353:H924 RS08610
gene id: 1121353:H924_RS08610
uniprot id: M1UFY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1121353:H924 RS09310
gene id: 1121353:H924_RS09310
uniprot id: M1UV62
names: Similarity
messages: Belongs to the peptidase C40 family.

1121353:H924 RS00270
gene id: 1121353:H924_RS00270
uniprot id: M1TMG2
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS02375
gene id: 1121353:H924_RS02375
uniprot id: M1UDC0
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1121353:H924 RS05935
gene id: 1121353:H924_RS05935
uniprot id: M1TQK5
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS12590
gene id: 1121353:H924_RS12590
uniprot id: M1UW99
names: Similarity
messages: Belongs to the PspA/IM30 family.

1121353:H924 RS09660
gene id: 1121353:H924_RS09660
uniprot id: M1UMF0
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

1121353:H924 RS12835
gene id: 1121353:H924_RS12835
uniprot id: M1UHT5
names: Cofactor
names: Similarity
messages: Belongs to the anthranilate synthase component I family.
messages: Binds 1 Mg(2+) ion per subunit.

1121353:H924 RS09890
gene id: 1121353:H924_RS09890
uniprot id: M1TT54
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the malate synthase family. GlcB subfamily.
messages: Cytoplasm
messages: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1121353:H924 RS08595
gene id: 1121353:H924_RS08595
uniprot id: M1UUV6
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS00715
gene id: 1121353:H924_RS00715
uniprot id: M1TMN7
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

1121353:H924 RS04105
gene id: 1121353:H924_RS04105
uniprot id: M1TPH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1121353:H924 RS12515
gene id: 1121353:H924_RS12515
uniprot id: M1TUM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1121353:H924 RS04040
gene id: 1121353:H924_RS04040
uniprot id: M1UK16
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

1121353:H924 RS07745
gene id: 1121353:H924_RS07745
uniprot id: M1TRV3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS07795
gene id: 1121353:H924_RS07795
uniprot id: M1TRW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1121353:H924 RS11705
gene id: 1121353:H924_RS11705
uniprot id: M1UNC3
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1121353:H924 RS06775
gene id: 1121353:H924_RS06775
uniprot id: M1UF55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS04020
gene id: 1121353:H924_RS04020
uniprot id: M1UE00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

1121353:H924 RS02240
gene id: 1121353:H924_RS02240
uniprot id: M1UJB1
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS02910
gene id: 1121353:H924_RS02910
uniprot id: M1UDK0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

1121353:H924 RS02040
gene id: 1121353:H924_RS02040
uniprot id: M1US03
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

1121353:H924 RS08875
gene id: 1121353:H924_RS08875
uniprot id: M1UUY8
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

1121353:H924 RS02505
gene id: 1121353:H924_RS02505
uniprot id: M1UDF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1121353:H924 RS04260
gene id: 1121353:H924_RS04260
uniprot id: M1UY22
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1121353:H924 RS09550
gene id: 1121353:H924_RS09550
uniprot id: M1UGD7
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1121353:H924 RS03405
gene id: 1121353:H924_RS03405
uniprot id: M1USL5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1121353:H924 RS05925
gene id: 1121353:H924_RS05925
uniprot id: M1UKV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1121353:H924 RS10255
gene id: 1121353:H924_RS10255
uniprot id: M1V001
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1121353:H924 RS08265
gene id: 1121353:H924_RS08265
uniprot id: M1UZC5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1121353:H924 RS00570
gene id: 1121353:H924_RS00570
uniprot id: M1TML2
names: Function
names: Similarity
messages: Belongs to the AMP nucleosidase family.
messages: Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.

1121353:H924 RS06205
gene id: 1121353:H924_RS06205
uniprot id: M1UEY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1121353:H924 RS09150
gene id: 1121353:H924_RS09150
uniprot id: M1UM71
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1121353:H924 RS11815
gene id: 1121353:H924_RS11815
uniprot id: M1TU54
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS04870
gene id: 1121353:H924_RS04870
uniprot id: M1TPW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1121353:H924 RS10885
gene id: 1121353:H924_RS10885
uniprot id: M1UMY3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1121353:H924 RS01935
gene id: 1121353:H924_RS01935
uniprot id: M1TNC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

1121353:H924 RS08320
gene id: 1121353:H924_RS08320
uniprot id: M1UZD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1121353:H924 RS12850
gene id: 1121353:H924_RS12850
uniprot id: M1V0T9
names: Function
names: Similarity
messages: Belongs to the TrpF family.
messages: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain.
messages: In the C-terminal section; belongs to the TrpF family.
messages: In the N-terminal section; belongs to the TrpC family.

1121353:H924 RS09775
gene id: 1121353:H924_RS09775
uniprot id: M1UVC4
names: Similarity
messages: Belongs to the disproportionating enzyme family.

1121353:H924 RS09370
gene id: 1121353:H924_RS09370
uniprot id: M1UMA7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1121353:H924 RS09170
gene id: 1121353:H924_RS09170
uniprot id: M1UZM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

1121353:H924 RS03180
gene id: 1121353:H924_RS03180
uniprot id: M1UXQ6
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS03055
gene id: 1121353:H924_RS03055
uniprot id: M1UXP4
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-73 and Arg-76) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

1121353:H924 RS07655
gene id: 1121353:H924_RS07655
uniprot id: M1ULJ8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS08685
gene id: 1121353:H924_RS08685
uniprot id: M1UFZ5
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1121353:H924 RS02395
gene id: 1121353:H924_RS02395
uniprot id: M1UJE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1121353:H924 RS08385
gene id: 1121353:H924_RS08385
uniprot id: M1TS70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

1121353:H924 RS02485
gene id: 1121353:H924_RS02485
uniprot id: M1TNS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1121353:H924 RS09865
gene id: 1121353:H924_RS09865
uniprot id: M1UGI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS09950
gene id: 1121353:H924_RS09950
uniprot id: M1UZW5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1121353:H924 RS00185
gene id: 1121353:H924_RS00185
uniprot id: M1UCE3
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.

1121353:H924 RS11960
gene id: 1121353:H924_RS11960
uniprot id: M1UNH2
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

1121353:H924 RS10935
gene id: 1121353:H924_RS10935
uniprot id: M1TTP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1121353:H924 RS03015
gene id: 1121353:H924_RS03015
uniprot id: M1UDL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1121353:H924 RS06510
gene id: 1121353:H924_RS06510
uniprot id: M1UF21
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

1121353:H924 RS01660
gene id: 1121353:H924_RS01660
uniprot id: M1UJ10
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS01485
gene id: 1121353:H924_RS01485
uniprot id: M1UCV8
names: Similarity
messages: Belongs to the peptidase C56 family.

1121353:H924 RS09200
gene id: 1121353:H924_RS09200
uniprot id: M1UM80
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS11270
gene id: 1121353:H924_RS11270
uniprot id: M1V084
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

1121353:H924 RS12160
gene id: 1121353:H924_RS12160
uniprot id: M1UNL2
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS10320
gene id: 1121353:H924_RS10320
uniprot id: M1V004
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS09705
gene id: 1121353:H924_RS09705
uniprot id: M1UZT7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1121353:H924 RS01675
gene id: 1121353:H924_RS01675
uniprot id: M1UX79
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

1121353:H924 RS08050
gene id: 1121353:H924_RS08050
uniprot id: M1UFR0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ChdC family. Type 2 subfamily.
messages: Fe-coproporphyrin III acts as both substrate and redox cofactor.
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate.

1121353:H924 RS12370
gene id: 1121353:H924_RS12370
uniprot id: M1TUI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

1121353:H924 RS00190
gene id: 1121353:H924_RS00190
uniprot id: M1TMF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

1121353:H924 RS02480
gene id: 1121353:H924_RS02480
uniprot id: M1UDE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1121353:H924 RS10705
gene id: 1121353:H924_RS10705
uniprot id: M1UGV3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

1121353:H924 RS11135
gene id: 1121353:H924_RS11135
uniprot id: M1UVR7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DyP-type peroxidase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.
messages: Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.

1121353:H924 RS01395
gene id: 1121353:H924_RS01395
uniprot id: M1UCU9
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.

1121353:H924 RS02400
gene id: 1121353:H924_RS02400
uniprot id: M1UDC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1121353:H924 RS10340
gene id: 1121353:H924_RS10340
uniprot id: M1UVJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS08515
gene id: 1121353:H924_RS08515
uniprot id: M1UUU7
names: Similarity
messages: Belongs to the UPF0246 family.

1121353:H924 RS06785
gene id: 1121353:H924_RS06785
uniprot id: M1UU41
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

1121353:H924 RS09245
gene id: 1121353:H924_RS09245
uniprot id: M1UZN3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1121353:H924 RS02615
gene id: 1121353:H924_RS02615
uniprot id: M1USB2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1121353:H924 RS02935
gene id: 1121353:H924_RS02935
uniprot id: M1UDK3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1121353:H924 RS04725
gene id: 1121353:H924_RS04725
uniprot id: M1UT99
names: Similarity
messages: In the C-terminal section; belongs to the anthranilate synthase component I family.

1121353:H924 RS08365
gene id: 1121353:H924_RS08365
uniprot id: M1UUS8
names: Similarity
messages: Belongs to the YciI family.

1121353:H924 RS05040
gene id: 1121353:H924_RS05040
uniprot id: M1TQ18
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS09300
gene id: 1121353:H924_RS09300
uniprot id: M1UG90
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1121353:H924 RS12980
gene id: 1121353:H924_RS12980
uniprot id: M1UWF5
names: Function
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.

1121353:H924 RS08400
gene id: 1121353:H924_RS08400
uniprot id: M1ULV2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1121353:H924 RS06600
gene id: 1121353:H924_RS06600
uniprot id: M1TR01
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS08800
gene id: 1121353:H924_RS08800
uniprot id: M1UUX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS06140
gene id: 1121353:H924_RS06140
uniprot id: M1UTU8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1121353:H924 RS10045
gene id: 1121353:H924_RS10045
uniprot id: M1TT97
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1121353:H924 RS06190
gene id: 1121353:H924_RS06190
uniprot id: M1UTV3
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.

1121353:H924 RS11680
gene id: 1121353:H924_RS11680
uniprot id: M1UNB9
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

1121353:H924 RS09395
gene id: 1121353:H924_RS09395
uniprot id: M1UMB0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

1121353:H924 RS05410
gene id: 1121353:H924_RS05410
uniprot id: M1UTL0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS09795
gene id: 1121353:H924_RS09795
uniprot id: M1TT23
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1121353:H924 RS07135
gene id: 1121353:H924_RS07135
uniprot id: M1UYZ0
names: Similarity
messages: Belongs to the UPF0237 family.

1121353:H924 RS06095
gene id: 1121353:H924_RS06095
uniprot id: M1UTU1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

1121353:H924 RS00660
gene id: 1121353:H924_RS00660
uniprot id: M1UIN2
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS10630
gene id: 1121353:H924_RS10630
uniprot id: M1UGU2
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1121353:H924 RS02105
gene id: 1121353:H924_RS02105
uniprot id: M1UD66
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1121353:H924 RS05895
gene id: 1121353:H924_RS05895
uniprot id: M1UYK4
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS04285
gene id: 1121353:H924_RS04285
uniprot id: M1UY24
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS05455
gene id: 1121353:H924_RS05455
uniprot id: M1TQ98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

1121353:H924 RS09400
gene id: 1121353:H924_RS09400
uniprot id: M1UGA7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1121353:H924 RS10740
gene id: 1121353:H924_RS10740
uniprot id: M1UVN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1121353:H924 RS11525
gene id: 1121353:H924_RS11525
uniprot id: M1TTZ6
names: Similarity
messages: Belongs to the CdaR family.

1121353:H924 RS07640
gene id: 1121353:H924_RS07640
uniprot id: M1TRT2
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1121353:H924 RS00985
gene id: 1121353:H924_RS00985
uniprot id: M1UIS5
names: Function
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: May catalyze the transamination reaction in phenylalanine biosynthesis.

1121353:H924 RS06065
gene id: 1121353:H924_RS06065
uniprot id: M1UTT7
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1121353:H924 RS01505
gene id: 1121353:H924_RS01505
uniprot id: M1UIY6
names: Similarity
messages: Belongs to the creatininase superfamily.

1121353:H924 RS04270
gene id: 1121353:H924_RS04270
uniprot id: M1UE38
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1121353:H924 RS06810
gene id: 1121353:H924_RS06810
uniprot id: M1UU46
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably functions as a manganese efflux pump.

1121353:H924 RS04430
gene id: 1121353:H924_RS04430
uniprot id: M1UY41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS10620
gene id: 1121353:H924_RS10620
uniprot id: M1V025
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1121353:H924 RS10445
gene id: 1121353:H924_RS10445
uniprot id: M1UGS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1121353:H924 RS01670
gene id: 1121353:H924_RS01670
uniprot id: M1URU1
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1121353:H924 RS02700
gene id: 1121353:H924_RS02700
uniprot id: M1UJJ7
names: Similarity
messages: Belongs to the CFA/CMAS family.

1121353:H924 RS09910
gene id: 1121353:H924_RS09910
uniprot id: M1UGJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCCT transporter (TC 2.A.15) family.
messages: Membrane

1121353:H924 RS02905
gene id: 1121353:H924_RS02905
uniprot id: M1UJM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1121353:H924 RS08605
gene id: 1121353:H924_RS08605
uniprot id: M1ULY4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

1121353:H924 RS12925
gene id: 1121353:H924_RS12925
uniprot id: M1UHU6
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS09160
gene id: 1121353:H924_RS09160
uniprot id: M1TSM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1121353:H924 RS11220
gene id: 1121353:H924_RS11220
uniprot id: M1V080
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

1121353:H924 RS10240
gene id: 1121353:H924_RS10240
uniprot id: M1UGP7
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS03345
gene id: 1121353:H924_RS03345
uniprot id: M1UDQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1121353:H924 RS00830
gene id: 1121353:H924_RS00830
uniprot id: M1UIQ5
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

1121353:H924 RS08460
gene id: 1121353:H924_RS08460
uniprot id: M1TS85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1121353:H924 RS02605
gene id: 1121353:H924_RS02605
uniprot id: M1UDG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1121353:H924 RS06460
gene id: 1121353:H924_RS06460
uniprot id: M1UF14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1121353:H924 RS02730
gene id: 1121353:H924_RS02730
uniprot id: M1UDH9
names: Similarity
messages: Belongs to the WXG100 family.

1121353:H924 RS00465
gene id: 1121353:H924_RS00465
uniprot id: M1UCH9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS13025
gene id: 1121353:H924_RS13025
uniprot id: M1TUY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

1121353:H924 RS01510
gene id: 1121353:H924_RS01510
uniprot id: M1UCW3
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS04240
gene id: 1121353:H924_RS04240
uniprot id: M1UY19
names: Similarity
messages: Belongs to the peptidase S1C family.

1121353:H924 RS00220
gene id: 1121353:H924_RS00220
uniprot id: M1URA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

1121353:H924 RS02100
gene id: 1121353:H924_RS02100
uniprot id: M1UJ85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1121353:H924 RS00950
gene id: 1121353:H924_RS00950
uniprot id: M1UX02
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1121353:H924 RS00745
gene id: 1121353:H924_RS00745
uniprot id: M1URH2
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS07840
gene id: 1121353:H924_RS07840
uniprot id: M1UFN8
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS08720
gene id: 1121353:H924_RS08720
uniprot id: M1TSD1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1121353:H924 RS03650
gene id: 1121353:H924_RS03650
uniprot id: M1TPA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

1121353:H924 RS08890
gene id: 1121353:H924_RS08890
uniprot id: M1UG27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1121353:H924 RS00705
gene id: 1121353:H924_RS00705
uniprot id: M1UIN8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1121353:H924 RS08495
gene id: 1121353:H924_RS08495
uniprot id: M1UZE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS06705
gene id: 1121353:H924_RS06705
uniprot id: M1TR23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1121353:H924 RS07480
gene id: 1121353:H924_RS07480
uniprot id: M1ULG2
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1121353:H924 RS07595
gene id: 1121353:H924_RS07595
uniprot id: M1UUI9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS11895
gene id: 1121353:H924_RS11895
uniprot id: M1TU72
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1121353:H924 RS06945
gene id: 1121353:H924_RS06945
uniprot id: M1UL86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

1121353:H924 RS01610
gene id: 1121353:H924_RS01610
uniprot id: M1UJ01
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1121353:H924 RS01105
gene id: 1121353:H924_RS01105
uniprot id: M1URL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

1121353:H924 RS07980
gene id: 1121353:H924_RS07980
uniprot id: M1UZA0
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS03570
gene id: 1121353:H924_RS03570
uniprot id: M1TP92
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1121353:H924 RS12385
gene id: 1121353:H924_RS12385
uniprot id: M1UNQ3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.

1121353:H924 RS04700
gene id: 1121353:H924_RS04700
uniprot id: M1UT94
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

1121353:H924 RS06050
gene id: 1121353:H924_RS06050
uniprot id: M1UKX1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1121353:H924 RS06640
gene id: 1121353:H924_RS06640
uniprot id: M1UL47
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1121353:H924 RS08835
gene id: 1121353:H924_RS08835
uniprot id: M1UM19
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

1121353:H924 RS04450
gene id: 1121353:H924_RS04450
uniprot id: M1UT40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

1121353:H924 RS11445
gene id: 1121353:H924_RS11445
uniprot id: M1UN73
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1121353:H924 RS04250
gene id: 1121353:H924_RS04250
uniprot id: M1TPK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

1121353:H924 RS09130
gene id: 1121353:H924_RS09130
uniprot id: M1UM67
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1121353:H924 RS03025
gene id: 1121353:H924_RS03025
uniprot id: M1USG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

1121353:H924 RS12425
gene id: 1121353:H924_RS12425
uniprot id: M1V0N9
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

1121353:H924 RS11400
gene id: 1121353:H924_RS11400
uniprot id: M1UH45
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1121353:H924 RS03465
gene id: 1121353:H924_RS03465
uniprot id: M1UJU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

1121353:H924 RS01790
gene id: 1121353:H924_RS01790
uniprot id: M1TN91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1121353:H924 RS10710
gene id: 1121353:H924_RS10710
uniprot id: M1TTM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

1121353:H924 RS12740
gene id: 1121353:H924_RS12740
uniprot id: M1UWC9
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1121353:H924 RS05500
gene id: 1121353:H924_RS05500
uniprot id: M1UKQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Membrane

1121353:H924 RS11535
gene id: 1121353:H924_RS11535
uniprot id: M1UN90
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1121353:H924 RS02835
gene id: 1121353:H924_RS02835
uniprot id: M1UDI9
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1121353:H924 RS06505
gene id: 1121353:H924_RS06505
uniprot id: M1UL29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1121353:H924 RS10945
gene id: 1121353:H924_RS10945
uniprot id: M1V051
names: Similarity
messages: Belongs to the PstS family.

1121353:H924 RS05640
gene id: 1121353:H924_RS05640
uniprot id: M1TQD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1121353:H924 RS07925
gene id: 1121353:H924_RS07925
uniprot id: M1UUM9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

1121353:H924 RS06495
gene id: 1121353:H924_RS06495
uniprot id: M1UU00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1121353:H924 RS02790
gene id: 1121353:H924_RS02790
uniprot id: M1UXM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinone-dependent D-lactate dehydrogenase family.
messages: Catalyzes the oxidation of D-lactate to pyruvate.
messages: Cell membrane

1121353:H924 RS00810
gene id: 1121353:H924_RS00810
uniprot id: M1UCM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS10385
gene id: 1121353:H924_RS10385
uniprot id: M1UGR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

1121353:H924 RS03275
gene id: 1121353:H924_RS03275
uniprot id: M1USJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1121353:H924 RS10160
gene id: 1121353:H924_RS10160
uniprot id: M1UMN0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1121353:H924 RS01335
gene id: 1121353:H924_RS01335
uniprot id: M1UX41
names: Similarity
messages: Belongs to the GSP E family.

1121353:H924 RS09375
gene id: 1121353:H924_RS09375
uniprot id: M1UGA2
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1121353:H924 RS09725
gene id: 1121353:H924_RS09725
uniprot id: M1UVB6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1121353:H924 RS10115
gene id: 1121353:H924_RS10115
uniprot id: M1UGN4
names: Similarity
messages: Belongs to the LOG family.

1121353:H924 RS03110
gene id: 1121353:H924_RS03110
uniprot id: M1UJQ3
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1121353:H924 RS04340
gene id: 1121353:H924_RS04340
uniprot id: M1UK58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1121353:H924 RS00160
gene id: 1121353:H924_RS00160
uniprot id: M1TME5
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

1121353:H924 RS06520
gene id: 1121353:H924_RS06520
uniprot id: M1UU03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

1121353:H924 RS06870
gene id: 1121353:H924_RS06870
uniprot id: M1UL76
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

1121353:H924 RS01045
gene id: 1121353:H924_RS01045
uniprot id: M1URK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1121353:H924 RS06395
gene id: 1121353:H924_RS06395
uniprot id: M1UTY5
names: Similarity
messages: Belongs to the universal stress protein A family.

1121353:H924 RS07920
gene id: 1121353:H924_RS07920
uniprot id: M1TRY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

1121353:H924 RS04410
gene id: 1121353:H924_RS04410
uniprot id: M1UY39
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS01765
gene id: 1121353:H924_RS01765
uniprot id: M1TN86
names: Similarity
messages: Belongs to the CsoR family.

1121353:H924 RS04315
gene id: 1121353:H924_RS04315
uniprot id: M1UK54
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Monomer.

1121353:H924 RS04620
gene id: 1121353:H924_RS04620
uniprot id: M1UT77
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1121353:H924 RS03200
gene id: 1121353:H924_RS03200
uniprot id: M1USI4
names: Similarity
messages: Belongs to the peptidase C40 family.

1121353:H924 RS13065
gene id: 1121353:H924_RS13065
uniprot id: M1UP29
names: Similarity
messages: Belongs to the thioredoxin family.

1121353:H924 RS01960
gene id: 1121353:H924_RS01960
uniprot id: M1TND4
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS01375
gene id: 1121353:H924_RS01375
uniprot id: M1TN08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1121353:H924 RS02870
gene id: 1121353:H924_RS02870
uniprot id: M1USE4
names: Similarity
messages: Belongs to the AAE transporter (TC 2.A.81) family.

1121353:H924 RS11800
gene id: 1121353:H924_RS11800
uniprot id: M1V0F8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

1121353:H924 RS11740
gene id: 1121353:H924_RS11740
uniprot id: M1TU38
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1121353:H924 RS07525
gene id: 1121353:H924_RS07525
uniprot id: M1UZ49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1121353:H924 RS09195
gene id: 1121353:H924_RS09195
uniprot id: M1UZM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1121353:H924 RS05485
gene id: 1121353:H924_RS05485
uniprot id: M1TQA3
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

1121353:H924 RS09720
gene id: 1121353:H924_RS09720
uniprot id: M1TT08
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS04160
gene id: 1121353:H924_RS04160
uniprot id: M1USX9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1121353:H924 RS01810
gene id: 1121353:H924_RS01810
uniprot id: M1UD11
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1121353:H924 RS07700
gene id: 1121353:H924_RS07700
uniprot id: M1UZ72
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1121353:H924 RS02210
gene id: 1121353:H924_RS02210
uniprot id: M1UXE6
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1121353:H924 RS12790
gene id: 1121353:H924_RS12790
uniprot id: M1UWD4
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS07075
gene id: 1121353:H924_RS07075
uniprot id: M1UU89
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1121353:H924 RS08510
gene id: 1121353:H924_RS08510
uniprot id: M1TS94
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1121353:H924 RS08820
gene id: 1121353:H924_RS08820
uniprot id: M1TSF3
names: Similarity
messages: Belongs to the acylphosphatase family.

1121353:H924 RS08360
gene id: 1121353:H924_RS08360
uniprot id: M1TS65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1121353:H924 RS11845
gene id: 1121353:H924_RS11845
uniprot id: M1UVZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1121353:H924 RS01035
gene id: 1121353:H924_RS01035
uniprot id: M1UCQ1
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS00015
gene id: 1121353:H924_RS00015
uniprot id: M1UR84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1121353:H924 RS05535
gene id: 1121353:H924_RS05535
uniprot id: M1TQB2
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS06910
gene id: 1121353:H924_RS06910
uniprot id: M1UU64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1121353:H924 RS08225
gene id: 1121353:H924_RS08225
uniprot id: M1UFT3
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1121353:H924 RS03375
gene id: 1121353:H924_RS03375
uniprot id: M1TP58
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

1121353:H924 RS08475
gene id: 1121353:H924_RS08475
uniprot id: M1ULW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1121353:H924 RS02020
gene id: 1121353:H924_RS02020
uniprot id: M1UXC0
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Could possibly oxidize fatty acids using specific components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS07130
gene id: 1121353:H924_RS07130
uniprot id: M1UU99
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS07715
gene id: 1121353:H924_RS07715
uniprot id: M1UFM1
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

1121353:H924 RS01860
gene id: 1121353:H924_RS01860
uniprot id: M1TNA9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1121353:H924 RS01600
gene id: 1121353:H924_RS01600
uniprot id: M1URT0
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

1121353:H924 RS03550
gene id: 1121353:H924_RS03550
uniprot id: M1USN6
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1121353:H924 RS03510
gene id: 1121353:H924_RS03510
uniprot id: M1UXT6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1121353:H924 RS08150
gene id: 1121353:H924_RS08150
uniprot id: M1UFS4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1121353:H924 RS03615
gene id: 1121353:H924_RS03615
uniprot id: M1UDU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

1121353:H924 RS04025
gene id: 1121353:H924_RS04025
uniprot id: M1TPG4
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1121353:H924 RS04720
gene id: 1121353:H924_RS04720
uniprot id: M1TPT3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS00655
gene id: 1121353:H924_RS00655
uniprot id: M1UWW9
names: Similarity
messages: Belongs to the peptidase M20A family.

1121353:H924 RS07095
gene id: 1121353:H924_RS07095
uniprot id: M1TRB2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS12675
gene id: 1121353:H924_RS12675
uniprot id: M1UNW2
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

1121353:H924 RS09885
gene id: 1121353:H924_RS09885
uniprot id: M1UGJ3
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.

1121353:H924 RS02380
gene id: 1121353:H924_RS02380
uniprot id: M1TNN4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1121353:H924 RS10860
gene id: 1121353:H924_RS10860
uniprot id: M1TTP0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1121353:H924 RS06580
gene id: 1121353:H924_RS06580
uniprot id: M1UU09
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS07950
gene id: 1121353:H924_RS07950
uniprot id: M1UUN2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1121353:H924 RS11280
gene id: 1121353:H924_RS11280
uniprot id: M1UH26
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

1121353:H924 RS05265
gene id: 1121353:H924_RS05265
uniprot id: M1UTJ4
names: Similarity
messages: Belongs to the LOG family.

1121353:H924 RS03645
gene id: 1121353:H924_RS03645
uniprot id: M1UDV2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

1121353:H924 RS07565
gene id: 1121353:H924_RS07565
uniprot id: M1TRR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

1121353:H924 RS05550
gene id: 1121353:H924_RS05550
uniprot id: M1UYH3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1121353:H924 RS13090
gene id: 1121353:H924_RS13090
uniprot id: M1UP32
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1121353:H924 RS06270
gene id: 1121353:H924_RS06270
uniprot id: M1UYN7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1121353:H924 RS11070
gene id: 1121353:H924_RS11070
uniprot id: M1V064
names: Similarity
messages: Belongs to the GARS family.

1121353:H924 RS07800
gene id: 1121353:H924_RS07800
uniprot id: M1UUL5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1121353:H924 RS11655
gene id: 1121353:H924_RS11655
uniprot id: M1UNB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS03150
gene id: 1121353:H924_RS03150
uniprot id: M1USH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1121353:H924 RS09030
gene id: 1121353:H924_RS09030
uniprot id: M1UM53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

1121353:H924 RS13115
gene id: 1121353:H924_RS13115
uniprot id: M1UP37
names: Similarity
messages: Belongs to the Gram-positive plasmids replication protein type 1 family.

1121353:H924 RS10485
gene id: 1121353:H924_RS10485
uniprot id: M1UMS4
names: Similarity
messages: Belongs to the hyi family.

1121353:H924 RS11255
gene id: 1121353:H924_RS11255
uniprot id: M1UH22
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1121353:H924 RS10010
gene id: 1121353:H924_RS10010
uniprot id: M1UMK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1121353:H924 RS11005
gene id: 1121353:H924_RS11005
uniprot id: M1UGY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

1121353:H924 RS09525
gene id: 1121353:H924_RS09525
uniprot id: M1TSW5
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

1121353:H924 RS11470
gene id: 1121353:H924_RS11470
uniprot id: M1UN77
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Cell membrane
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS05950
gene id: 1121353:H924_RS05950
uniprot id: M1UKW1
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1121353:H924 RS02170
gene id: 1121353:H924_RS02170
uniprot id: M1UD80
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS08340
gene id: 1121353:H924_RS08340
uniprot id: M1UUS5
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS01685
gene id: 1121353:H924_RS01685
uniprot id: M1UCZ0
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

1121353:H924 RS12685
gene id: 1121353:H924_RS12685
uniprot id: M1TUS7
names: Similarity
messages: Belongs to the UPF0371 family.

1121353:H924 RS02450
gene id: 1121353:H924_RS02450
uniprot id: M1UJF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1121353:H924 RS10065
gene id: 1121353:H924_RS10065
uniprot id: M1UGM3
names: Similarity
messages: Belongs to the pirin family.

1121353:H924 RS00350
gene id: 1121353:H924_RS00350
uniprot id: M1URC3
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS02670
gene id: 1121353:H924_RS02670
uniprot id: M1UXL0
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1121353:H924 RS01180
gene id: 1121353:H924_RS01180
uniprot id: M1URM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS02660
gene id: 1121353:H924_RS02660
uniprot id: M1TNV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1121353:H924 RS01215
gene id: 1121353:H924_RS01215
uniprot id: M1UIV1
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS07590
gene id: 1121353:H924_RS07590
uniprot id: M1TRS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

1121353:H924 RS02785
gene id: 1121353:H924_RS02785
uniprot id: M1USD5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1121353:H924 RS10250
gene id: 1121353:H924_RS10250
uniprot id: M1UVJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1121353:H924 RS11770
gene id: 1121353:H924_RS11770
uniprot id: M1UVY7
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

1121353:H924 RS02435
gene id: 1121353:H924_RS02435
uniprot id: M1TNQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1121353:H924 RS11465
gene id: 1121353:H924_RS11465
uniprot id: M1V0A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1121353:H924 RS04455
gene id: 1121353:H924_RS04455
uniprot id: M1UY44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreF family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

1121353:H924 RS11010
gene id: 1121353:H924_RS11010
uniprot id: M1TTQ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1121353:H924 RS07010
gene id: 1121353:H924_RS07010
uniprot id: M1TR89
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
messages: Monomer.

1121353:H924 RS01885
gene id: 1121353:H924_RS01885
uniprot id: M1TNB4
names: Similarity
messages: Belongs to the peptidase C56 family.

1121353:H924 RS10355
gene id: 1121353:H924_RS10355
uniprot id: M1UGR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS05215
gene id: 1121353:H924_RS05215
uniprot id: M1UTI9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MshB deacetylase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.

1121353:H924 RS02755
gene id: 1121353:H924_RS02755
uniprot id: M1TNW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1121353:H924 RS01770
gene id: 1121353:H924_RS01770
uniprot id: M1URV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

1121353:H924 RS10800
gene id: 1121353:H924_RS10800
uniprot id: M1UVN9
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS00870
gene id: 1121353:H924_RS00870
uniprot id: M1URI9
names: Similarity
messages: Belongs to the peptidase M13 family.

1121353:H924 RS10540
gene id: 1121353:H924_RS10540
uniprot id: M1V019
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

1121353:H924 RS07575
gene id: 1121353:H924_RS07575
uniprot id: M1UZ59
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1121353:H924 RS04475
gene id: 1121353:H924_RS04475
uniprot id: M1UT45
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS08175
gene id: 1121353:H924_RS08175
uniprot id: M1UFS6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1121353:H924 RS00005
gene id: 1121353:H924_RS00005
uniprot id: M1UCC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1121353:H924 RS04560
gene id: 1121353:H924_RS04560
uniprot id: M1UE86
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS07680
gene id: 1121353:H924_RS07680
uniprot id: M1ULK2
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

1121353:H924 RS01550
gene id: 1121353:H924_RS01550
uniprot id: M1UX64
names: Similarity
messages: Belongs to the peptidase M1 family.

1121353:H924 RS12700
gene id: 1121353:H924_RS12700
uniprot id: M1UNX1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

1121353:H924 RS06120
gene id: 1121353:H924_RS06120
uniprot id: M1UYM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS05955
gene id: 1121353:H924_RS05955
uniprot id: M1UEU7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

1121353:H924 RS05695
gene id: 1121353:H924_RS05695
uniprot id: M1UTP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1121353:H924 RS00775
gene id: 1121353:H924_RS00775
uniprot id: M1UWY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1121353:H924 RS02645
gene id: 1121353:H924_RS02645
uniprot id: M1UXK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1121353:H924 RS09315
gene id: 1121353:H924_RS09315
uniprot id: M1UZP3
names: Similarity
messages: Belongs to the peptidase C40 family.

1121353:H924 RS03610
gene id: 1121353:H924_RS03610
uniprot id: M1UJW6
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1121353:H924 RS01020
gene id: 1121353:H924_RS01020
uniprot id: M1UX08
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

1121353:H924 RS06225
gene id: 1121353:H924_RS06225
uniprot id: M1UKZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS00405
gene id: 1121353:H924_RS00405
uniprot id: M1UWU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

1121353:H924 RS00885
gene id: 1121353:H924_RS00885
uniprot id: M1UCN4
names: Similarity
messages: Belongs to the glutamate synthase family.

1121353:H924 RS09190
gene id: 1121353:H924_RS09190
uniprot id: M1UV42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1121353:H924 RS04780
gene id: 1121353:H924_RS04780
uniprot id: M1UY85
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1121353:H924 RS12845
gene id: 1121353:H924_RS12845
uniprot id: M1UWE0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS05905
gene id: 1121353:H924_RS05905
uniprot id: M1UEU1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS07600
gene id: 1121353:H924_RS07600
uniprot id: M1UZ62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1121353:H924 RS00165
gene id: 1121353:H924_RS00165
uniprot id: M1UR98
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

1121353:H924 RS02655
gene id: 1121353:H924_RS02655
uniprot id: M1UDH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1121353:H924 RS11275
gene id: 1121353:H924_RS11275
uniprot id: M1UN44
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS12990
gene id: 1121353:H924_RS12990
uniprot id: M1UP17
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS04480
gene id: 1121353:H924_RS04480
uniprot id: M1UY46
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS08705
gene id: 1121353:H924_RS08705
uniprot id: M1ULZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1121353:H924 RS03530
gene id: 1121353:H924_RS03530
uniprot id: M1UXU0
names: Similarity
messages: Belongs to the DEAD box helicase family.

1121353:H924 RS00290
gene id: 1121353:H924_RS00290
uniprot id: M1UCF6
names: Similarity
messages: Belongs to the CsoR family.

1121353:H924 RS02950
gene id: 1121353:H924_RS02950
uniprot id: M1UXN3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1121353:H924 RS09515
gene id: 1121353:H924_RS09515
uniprot id: M1UMD1
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1121353:H924 RS09220
gene id: 1121353:H924_RS09220
uniprot id: M1UZM9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1121353:H924 RS04100
gene id: 1121353:H924_RS04100
uniprot id: M1UE11
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

1121353:H924 RS04645
gene id: 1121353:H924_RS04645
uniprot id: M1TPR9
names: Subcellular Location Annotation
messages: Cytoplasm

1121353:H924 RS00900
gene id: 1121353:H924_RS00900
uniprot id: M1UWZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.
messages: Belongs to the emb family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS10135
gene id: 1121353:H924_RS10135
uniprot id: M1UMM7
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1121353:H924 RS08450
gene id: 1121353:H924_RS08450
uniprot id: M1ULW1
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS10880
gene id: 1121353:H924_RS10880
uniprot id: M1V045
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1121353:H924 RS02070
gene id: 1121353:H924_RS02070
uniprot id: M1UXC7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1121353:H924 RS01210
gene id: 1121353:H924_RS01210
uniprot id: M1UX28
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS05665
gene id: 1121353:H924_RS05665
uniprot id: M1TQE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1121353:H924 RS10190
gene id: 1121353:H924_RS10190
uniprot id: M1UGP2
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

1121353:H924 RS11110
gene id: 1121353:H924_RS11110
uniprot id: M1UVR6
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS09145
gene id: 1121353:H924_RS09145
uniprot id: M1UZM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

1121353:H924 RS07610
gene id: 1121353:H924_RS07610
uniprot id: M1UFK6
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1121353:H924 RS13080
gene id: 1121353:H924_RS13080
uniprot id: M1UWG6
names: Similarity
messages: Belongs to the ParB family.

1121353:H924 RS07465
gene id: 1121353:H924_RS07465
uniprot id: M1TRL1
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

1121353:H924 RS11710
gene id: 1121353:H924_RS11710
uniprot id: M1UH93
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS05990
gene id: 1121353:H924_RS05990
uniprot id: M1UTT3
names: Similarity
messages: Belongs to the isochorismate synthase family.

1121353:H924 RS11925
gene id: 1121353:H924_RS11925
uniprot id: M1UW09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS05325
gene id: 1121353:H924_RS05325
uniprot id: M1UEL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1121353:H924 RS09380
gene id: 1121353:H924_RS09380
uniprot id: M1TSS4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

1121353:H924 RS06575
gene id: 1121353:H924_RS06575
uniprot id: M1TQZ6
names: Similarity
messages: Belongs to the TlyA family.

1121353:H924 RS13055
gene id: 1121353:H924_RS13055
uniprot id: M1UWG4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1121353:H924 RS00690
gene id: 1121353:H924_RS00690
uniprot id: M1TMN3
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS08435
gene id: 1121353:H924_RS08435
uniprot id: M1TS80
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1121353:H924 RS06740
gene id: 1121353:H924_RS06740
uniprot id: M1UYU2
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS03085
gene id: 1121353:H924_RS03085
uniprot id: M1UJP9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1121353:H924 RS05705
gene id: 1121353:H924_RS05705
uniprot id: M1UKS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein SsuA/TauA family.
messages: Periplasm

1121353:H924 RS06480
gene id: 1121353:H924_RS06480
uniprot id: M1UL27
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1121353:H924 RS07540
gene id: 1121353:H924_RS07540
uniprot id: M1TRQ6
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

1121353:H924 RS03415
gene id: 1121353:H924_RS03415
uniprot id: M1UJU2
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

1121353:H924 RS09895
gene id: 1121353:H924_RS09895
uniprot id: M1UVE1
names: Cofactor
messages: Can also use Mn(2+) ion.

1121353:H924 RS04520
gene id: 1121353:H924_RS04520
uniprot id: M1TPP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1121353:H924 RS02915
gene id: 1121353:H924_RS02915
uniprot id: M1TNZ1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1121353:H924 RS08200
gene id: 1121353:H924_RS08200
uniprot id: M1UFT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

1121353:H924 RS03175
gene id: 1121353:H924_RS03175
uniprot id: M1USI1
names: Similarity
messages: Belongs to the peptidase S11 family.

1121353:H924 RS10400
gene id: 1121353:H924_RS10400
uniprot id: M1V009
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1121353:H924 RS13220
gene id: 1121353:H924_RS13220
uniprot id: M1UHX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1121353:H924 RS09815
gene id: 1121353:H924_RS09815
uniprot id: M1UGI0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm

1121353:H924 RS04910
gene id: 1121353:H924_RS04910
uniprot id: M1UKF2
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1121353:H924 RS01145
gene id: 1121353:H924_RS01145
uniprot id: M1UCR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Homodimer.

1121353:H924 RS11455
gene id: 1121353:H924_RS11455
uniprot id: M1TTY4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

1121353:H924 RS04175
gene id: 1121353:H924_RS04175
uniprot id: M1UE22
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS09080
gene id: 1121353:H924_RS09080
uniprot id: M1UM61
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1121353:H924 RS08885
gene id: 1121353:H924_RS08885
uniprot id: M1UM27
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

1121353:H924 RS10230
gene id: 1121353:H924_RS10230
uniprot id: M1UZZ8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1121353:H924 RS08860
gene id: 1121353:H924_RS08860
uniprot id: M1UM26
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

1121353:H924 RS10840
gene id: 1121353:H924_RS10840
uniprot id: M1UVP2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS08095
gene id: 1121353:H924_RS08095
uniprot id: M1ULQ7
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1121353:H924 RS01665
gene id: 1121353:H924_RS01665
uniprot id: M1TN66
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1121353:H924 RS12435
gene id: 1121353:H924_RS12435
uniprot id: M1UHL8
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1121353:H924 RS06145
gene id: 1121353:H924_RS06145
uniprot id: M1UYM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1121353:H924 RS00020
gene id: 1121353:H924_RS00020
uniprot id: M1UWR6
names: Similarity
messages: Belongs to the UPF0232 family.

1121353:H924 RS10220
gene id: 1121353:H924_RS10220
uniprot id: M1TTE8
names: Similarity
messages: Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.

1121353:H924 RS08770
gene id: 1121353:H924_RS08770
uniprot id: M1TSE3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

1121353:H924 RS13455
gene id: 1121353:H924_RS13455
uniprot id: M1UWK9
names: Similarity
messages: Belongs to the peptidase C40 family.

1121353:H924 RS04435
gene id: 1121353:H924_RS04435
uniprot id: M1UK75
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

1121353:H924 RS10490
gene id: 1121353:H924_RS10490
uniprot id: M1UGS7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1121353:H924 RS02495
gene id: 1121353:H924_RS02495
uniprot id: M1UXJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1121353:H924 RS09415
gene id: 1121353:H924_RS09415
uniprot id: M1UZQ5
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS06540
gene id: 1121353:H924_RS06540
uniprot id: M1TQZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1121353:H924 RS11785
gene id: 1121353:H924_RS11785
uniprot id: M1UHA4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1121353:H924 RS10855
gene id: 1121353:H924_RS10855
uniprot id: M1UGX2
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1121353:H924 RS11120
gene id: 1121353:H924_RS11120
uniprot id: M1UN20
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS09640
gene id: 1121353:H924_RS09640
uniprot id: M1UGF2
names: Similarity
messages: Belongs to the ribonuclease N1/T1 family.

1121353:H924 RS04050
gene id: 1121353:H924_RS04050
uniprot id: M1TPG8
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1121353:H924 RS08795
gene id: 1121353:H924_RS08795
uniprot id: M1TSE8
names: Similarity
messages: Belongs to the P(II) protein family.

1121353:H924 RS06610
gene id: 1121353:H924_RS06610
uniprot id: M1UYS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1121353:H924 RS07645
gene id: 1121353:H924_RS07645
uniprot id: M1UUJ5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1121353:H924 RS04120
gene id: 1121353:H924_RS04120
uniprot id: M1UK24
names: Similarity
messages: Belongs to the FPG family.

1121353:H924 RS08145
gene id: 1121353:H924_RS08145
uniprot id: M1ULR5
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1121353:H924 RS11015
gene id: 1121353:H924_RS11015
uniprot id: M1UVQ6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1121353:H924 RS01525
gene id: 1121353:H924_RS01525
uniprot id: M1UX62
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

1121353:H924 RS08600
gene id: 1121353:H924_RS08600
uniprot id: M1UZF5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1121353:H924 RS07910
gene id: 1121353:H924_RS07910
uniprot id: M1ULN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1121353:H924 RS01750
gene id: 1121353:H924_RS01750
uniprot id: M1UX88
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

1121353:H924 RS00045
gene id: 1121353:H924_RS00045
uniprot id: M1UWR9
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1121353:H924 RS02500
gene id: 1121353:H924_RS02500
uniprot id: M1UJG8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1121353:H924 RS08645
gene id: 1121353:H924_RS08645
uniprot id: M1UUW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

1121353:H924 RS10025
gene id: 1121353:H924_RS10025
uniprot id: M1UVG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1121353:H924 RS01270
gene id: 1121353:H924_RS01270
uniprot id: M1UIV6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1121353:H924 RS11940
gene id: 1121353:H924_RS11940
uniprot id: M1UHC8
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

1121353:H924 RS12915
gene id: 1121353:H924_RS12915
uniprot id: M1V0U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

1121353:H924 RS04705
gene id: 1121353:H924_RS04705
uniprot id: M1UY75
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS07895
gene id: 1121353:H924_RS07895
uniprot id: M1TRY4
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1121353:H924 RS08945
gene id: 1121353:H924_RS08945
uniprot id: M1TSH8
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1121353:H924 RS08840
gene id: 1121353:H924_RS08840
uniprot id: M1UG18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1121353:H924 RS11145
gene id: 1121353:H924_RS11145
uniprot id: M1UN25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

1121353:H924 RS03065
gene id: 1121353:H924_RS03065
uniprot id: M1UDM0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS13145
gene id: 1121353:H924_RS13145
uniprot id: M1UHX1
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

1121353:H924 RS11040
gene id: 1121353:H924_RS11040
uniprot id: M1UVQ9
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS05735
gene id: 1121353:H924_RS05735
uniprot id: M1UER5
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1121353:H924 RS04345
gene id: 1121353:H924_RS04345
uniprot id: M1UE51
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

1121353:H924 RS02025
gene id: 1121353:H924_RS02025
uniprot id: M1UJ75
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

1121353:H924 RS10940
gene id: 1121353:H924_RS10940
uniprot id: M1UVP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1121353:H924 RS07080
gene id: 1121353:H924_RS07080
uniprot id: M1UYY4
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS03230
gene id: 1121353:H924_RS03230
uniprot id: M1UXR1
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1121353:H924 RS04065
gene id: 1121353:H924_RS04065
uniprot id: M1UK18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1121353:H924 RS10075
gene id: 1121353:H924_RS10075
uniprot id: M1UVH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1121353:H924 RS04550
gene id: 1121353:H924_RS04550
uniprot id: M1UY55
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS10570
gene id: 1121353:H924_RS10570
uniprot id: M1UMT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

1121353:H924 RS10105
gene id: 1121353:H924_RS10105
uniprot id: M1UZY8
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1121353:H924 RS06160
gene id: 1121353:H924_RS06160
uniprot id: M1TQQ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1121353:H924 RS07585
gene id: 1121353:H924_RS07585
uniprot id: M1UFK3
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

1121353:H924 RS12380
gene id: 1121353:H924_RS12380
uniprot id: M1V0N2
names: Similarity
messages: Belongs to the pyruvate kinase family.

1121353:H924 RS00085
gene id: 1121353:H924_RS00085
uniprot id: M1UWS1
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS09345
gene id: 1121353:H924_RS09345
uniprot id: M1UMA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

1121353:H924 RS09420
gene id: 1121353:H924_RS09420
uniprot id: M1UMB5
names: Similarity
messages: Belongs to the glutamine synthetase family.

1121353:H924 RS00420
gene id: 1121353:H924_RS00420
uniprot id: M1TMJ0
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS06585
gene id: 1121353:H924_RS06585
uniprot id: M1UYS3
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1121353:H924 RS02335
gene id: 1121353:H924_RS02335
uniprot id: M1TNM4
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS08305
gene id: 1121353:H924_RS08305
uniprot id: M1UFU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS11910
gene id: 1121353:H924_RS11910
uniprot id: M1UNG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1121353:H924 RS11695
gene id: 1121353:H924_RS11695
uniprot id: M1UVX6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1121353:H924 RS09240
gene id: 1121353:H924_RS09240
uniprot id: M1UV51
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1121353:H924 RS02890
gene id: 1121353:H924_RS02890
uniprot id: M1TNY7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1121353:H924 RS00765
gene id: 1121353:H924_RS00765
uniprot id: M1TMP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS01015
gene id: 1121353:H924_RS01015
uniprot id: M1URK6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

1121353:H924 RS11265
gene id: 1121353:H924_RS11265
uniprot id: M1UVT0
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS11875
gene id: 1121353:H924_RS11875
uniprot id: M1UW02
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

1121353:H924 RS11885
gene id: 1121353:H924_RS11885
uniprot id: M1UNF6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1121353:H924 RS10950
gene id: 1121353:H924_RS10950
uniprot id: M1UMZ2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. MshD subfamily.
messages: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1121353:H924 RS06790
gene id: 1121353:H924_RS06790
uniprot id: M1UYU8
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

1121353:H924 RS09800
gene id: 1121353:H924_RS09800
uniprot id: M1UVC7
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

1121353:H924 RS05055
gene id: 1121353:H924_RS05055
uniprot id: M1UKI8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 3 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1121353:H924 RS04200
gene id: 1121353:H924_RS04200
uniprot id: M1UE26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

1121353:H924 RS11365
gene id: 1121353:H924_RS11365
uniprot id: M1UVU0
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.
messages: Reversible hydration of carbon dioxide.

1121353:H924 RS07635
gene id: 1121353:H924_RS07635
uniprot id: M1UFL0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

1121353:H924 RS02190
gene id: 1121353:H924_RS02190
uniprot id: M1UJA2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1121353:H924 RS05890
gene id: 1121353:H924_RS05890
uniprot id: M1UTR9
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS09880
gene id: 1121353:H924_RS09880
uniprot id: M1UZV7
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1121353:H924 RS08190
gene id: 1121353:H924_RS08190
uniprot id: M1UZB7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1121353:H924 RS06780
gene id: 1121353:H924_RS06780
uniprot id: M1TR40
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

1121353:H924 RS12520
gene id: 1121353:H924_RS12520
uniprot id: M1UW90
names: Similarity
messages: Belongs to the universal stress protein A family.

1121353:H924 RS08390
gene id: 1121353:H924_RS08390
uniprot id: M1UUT1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1121353:H924 RS09545
gene id: 1121353:H924_RS09545
uniprot id: M1UMD4
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

1121353:H924 RS08500
gene id: 1121353:H924_RS08500
uniprot id: M1ULW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1121353:H924 RS11835
gene id: 1121353:H924_RS11835
uniprot id: M1UHB3
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS06440
gene id: 1121353:H924_RS06440
uniprot id: M1TQW7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1121353:H924 RS06250
gene id: 1121353:H924_RS06250
uniprot id: M1UKZ7
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1121353:H924 RS05650
gene id: 1121353:H924_RS05650
uniprot id: M1UYI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1121353:H924 RS01100
gene id: 1121353:H924_RS01100
uniprot id: M1TMU7
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1121353:H924 RS00425
gene id: 1121353:H924_RS00425
uniprot id: M1URD2
names: Subcellular Location Annotation
messages: Cytoplasm

1121353:H924 RS03170
gene id: 1121353:H924_RS03170
uniprot id: M1TP27
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS10805
gene id: 1121353:H924_RS10805
uniprot id: M1V040
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS03975
gene id: 1121353:H924_RS03975
uniprot id: M1TPF6
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

1121353:H924 RS09265
gene id: 1121353:H924_RS09265
uniprot id: M1UV55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

1121353:H924 RS08315
gene id: 1121353:H924_RS08315
uniprot id: M1UUS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

1121353:H924 RS09390
gene id: 1121353:H924_RS09390
uniprot id: M1UZQ2
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1121353:H924 RS11285
gene id: 1121353:H924_RS11285
uniprot id: M1TTV3
names: Similarity
messages: Belongs to the DapA family.

1121353:H924 RS01875
gene id: 1121353:H924_RS01875
uniprot id: M1UJ48
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1121353:H924 RS12860
gene id: 1121353:H924_RS12860
uniprot id: M1UHT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1121353:H924 RS04205
gene id: 1121353:H924_RS04205
uniprot id: M1TPJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1121353:H924 RS12135
gene id: 1121353:H924_RS12135
uniprot id: M1UNK6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

1121353:H924 RS08140
gene id: 1121353:H924_RS08140
uniprot id: M1UZB3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1121353:H924 RS12605
gene id: 1121353:H924_RS12605
uniprot id: M1UHP5
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS12760
gene id: 1121353:H924_RS12760
uniprot id: M1TUU6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS04305
gene id: 1121353:H924_RS04305
uniprot id: M1UT09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Belongs to the precorrin methyltransferase family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1121353:H924 RS07770
gene id: 1121353:H924_RS07770
uniprot id: M1TRV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1121353:H924 RS02110
gene id: 1121353:H924_RS02110
uniprot id: M1TNG7
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1121353:H924 RS06535
gene id: 1121353:H924_RS06535
uniprot id: M1UF25
names: Similarity
messages: Belongs to the UPF0434 family.

1121353:H924 RS07470
gene id: 1121353:H924_RS07470
uniprot id: M1UUG0
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1121353:H924 RS02665
gene id: 1121353:H924_RS02665
uniprot id: M1USB8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1121353:H924 RS01170
gene id: 1121353:H924_RS01170
uniprot id: M1UCR8
names: Similarity
messages: Belongs to the catalase family.

1121353:H924 RS01040
gene id: 1121353:H924_RS01040
uniprot id: M1TMU0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS00440
gene id: 1121353:H924_RS00440
uniprot id: M1UCH5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1121353:H924 RS10730
gene id: 1121353:H924_RS10730
uniprot id: M1UGV7
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

1121353:H924 RS08785
gene id: 1121353:H924_RS08785
uniprot id: M1UM12
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1121353:H924 RS08545
gene id: 1121353:H924_RS08545
uniprot id: M1UUV1
names: Similarity
messages: Belongs to the MQO family.

1121353:H924 RS01095
gene id: 1121353:H924_RS01095
uniprot id: M1UCQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1121353:H924 RS08245
gene id: 1121353:H924_RS08245
uniprot id: M1ULS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1121353:H924 RS08430
gene id: 1121353:H924_RS08430
uniprot id: M1UFV7
names: Similarity
messages: Belongs to the ribF family.

1121353:H924 RS05930
gene id: 1121353:H924_RS05930
uniprot id: M1UEU4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS08660
gene id: 1121353:H924_RS08660
uniprot id: M1UFZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1121353:H924 RS08070
gene id: 1121353:H924_RS08070
uniprot id: M1ULQ3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1121353:H924 RS10790
gene id: 1121353:H924_RS10790
uniprot id: M1UGW4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1121353:H924 RS03235
gene id: 1121353:H924_RS03235
uniprot id: M1UJR8
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

1121353:H924 RS00205
gene id: 1121353:H924_RS00205
uniprot id: M1UIH7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1121353:H924 RS00335
gene id: 1121353:H924_RS00335
uniprot id: M1UIJ3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1121353:H924 RS01595
gene id: 1121353:H924_RS01595
uniprot id: M1TN49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

1121353:H924 RS06415
gene id: 1121353:H924_RS06415
uniprot id: M1TQW0
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS07630
gene id: 1121353:H924_RS07630
uniprot id: M1ULJ5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1121353:H924 RS11955
gene id: 1121353:H924_RS11955
uniprot id: M1V0H8
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

1121353:H924 RS12270
gene id: 1121353:H924_RS12270
uniprot id: M1UW52
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS06500
gene id: 1121353:H924_RS06500
uniprot id: M1UYR2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1121353:H924 RS07625
gene id: 1121353:H924_RS07625
uniprot id: M1UZ65
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

1121353:H924 RS04960
gene id: 1121353:H924_RS04960
uniprot id: M1UKG1
names: Function
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.

1121353:H924 RS02760
gene id: 1121353:H924_RS02760
uniprot id: M1USD1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1121353:H924 RS02000
gene id: 1121353:H924_RS02000
uniprot id: M1UJ70
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS06485
gene id: 1121353:H924_RS06485
uniprot id: M1UF18
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1121353:H924 RS09475
gene id: 1121353:H924_RS09475
uniprot id: M1TSV2
names: Similarity
messages: Belongs to the glutamine synthetase family.

1121353:H924 RS05225
gene id: 1121353:H924_RS05225
uniprot id: M1UKL7
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1121353:H924 RS08910
gene id: 1121353:H924_RS08910
uniprot id: M1UM33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1121353:H924 RS09280
gene id: 1121353:H924_RS09280
uniprot id: M1UG87
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.
messages: Homodimer.

1121353:H924 RS00385
gene id: 1121353:H924_RS00385
uniprot id: M1UIJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

1121353:H924 RS07685
gene id: 1121353:H924_RS07685
uniprot id: M1UFL9
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS08535
gene id: 1121353:H924_RS08535
uniprot id: M1TS99
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

1121353:H924 RS05855
gene id: 1121353:H924_RS05855
uniprot id: M1UET2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1121353:H924 RS02250
gene id: 1121353:H924_RS02250
uniprot id: M1TNK3
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS09470
gene id: 1121353:H924_RS09470
uniprot id: M1UGC1
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

1121353:H924 RS01110
gene id: 1121353:H924_RS01110
uniprot id: M1UX16
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

1121353:H924 RS07740
gene id: 1121353:H924_RS07740
uniprot id: M1UFM4
names: Similarity
messages: Belongs to the peptidase M24B family.

1121353:H924 RS04760
gene id: 1121353:H924_RS04760
uniprot id: M1UKC7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

1121353:H924 RS09070
gene id: 1121353:H924_RS09070
uniprot id: M1UV20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

1121353:H924 RS05555
gene id: 1121353:H924_RS05555
uniprot id: M1UKQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1121353:H924 RS10200
gene id: 1121353:H924_RS10200
uniprot id: M1UVI7
names: Similarity
names: Subunit
messages: Belongs to the muconolactone Delta-isomerase family.
messages: Homodecamer.

1121353:H924 RS07760
gene id: 1121353:H924_RS07760
uniprot id: M1ULL2
names: Similarity
messages: Belongs to the peptidase A24 family.

1121353:H924 RS03320
gene id: 1121353:H924_RS03320
uniprot id: M1TP50
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1121353:H924 RS11430
gene id: 1121353:H924_RS11430
uniprot id: M1TTX9
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

1121353:H924 RS09135
gene id: 1121353:H924_RS09135
uniprot id: M1TSL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

1121353:H924 RS10985
gene id: 1121353:H924_RS10985
uniprot id: M1TTQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1121353:H924 RS08310
gene id: 1121353:H924_RS08310
uniprot id: M1TS55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1121353:H924 RS03990
gene id: 1121353:H924_RS03990
uniprot id: M1UK11
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

1121353:H924 RS01700
gene id: 1121353:H924_RS01700
uniprot id: M1UX82
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

1121353:H924 RS06350
gene id: 1121353:H924_RS06350
uniprot id: M1UYP4
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1121353:H924 RS04880
gene id: 1121353:H924_RS04880
uniprot id: M1UY98
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

1121353:H924 RS05800
gene id: 1121353:H924_RS05800
uniprot id: M1UKU0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1121353:H924 RS02620
gene id: 1121353:H924_RS02620
uniprot id: M1UXK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1121353:H924 RS05760
gene id: 1121353:H924_RS05760
uniprot id: M1TQG3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS09940
gene id: 1121353:H924_RS09940
uniprot id: M1TT70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1121353:H924 RS12505
gene id: 1121353:H924_RS12505
uniprot id: M1UNS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1121353:H924 RS04795
gene id: 1121353:H924_RS04795
uniprot id: M1TPU8
names: Similarity
messages: Belongs to the FBPase class 2 family.

1121353:H924 RS08410
gene id: 1121353:H924_RS08410
uniprot id: M1TS75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1121353:H924 RS01420
gene id: 1121353:H924_RS01420
uniprot id: M1UX50
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1121353:H924 RS00640
gene id: 1121353:H924_RS00640
uniprot id: M1UCK0
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS07695
gene id: 1121353:H924_RS07695
uniprot id: M1UUK2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

1121353:H924 RS12715
gene id: 1121353:H924_RS12715
uniprot id: M1UWC6
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS04180
gene id: 1121353:H924_RS04180
uniprot id: M1TPI9
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1121353:H924 RS09780
gene id: 1121353:H924_RS09780
uniprot id: M1UZU6
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS02115
gene id: 1121353:H924_RS02115
uniprot id: M1US11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1121353:H924 RS00345
gene id: 1121353:H924_RS00345
uniprot id: M1TMH7
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

1121353:H924 RS11260
gene id: 1121353:H924_RS11260
uniprot id: M1TTV0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1121353:H924 RS02530
gene id: 1121353:H924_RS02530
uniprot id: M1UDF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1121353:H924 RS03350
gene id: 1121353:H924_RS03350
uniprot id: M1TP55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1121353:H924 RS05245
gene id: 1121353:H924_RS05245
uniprot id: M1UYE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.

1121353:H924 RS06180
gene id: 1121353:H924_RS06180
uniprot id: M1UEX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1121353:H924 RS13095
gene id: 1121353:H924_RS13095
uniprot id: M1UHW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1121353:H924 RS06975
gene id: 1121353:H924_RS06975
uniprot id: M1UF89
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

1121353:H924 RS02295
gene id: 1121353:H924_RS02295
uniprot id: M1UXG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1121353:H924 RS12620
gene id: 1121353:H924_RS12620
uniprot id: M1V0R0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1121353:H924 RS02510
gene id: 1121353:H924_RS02510
uniprot id: M1TNS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1121353:H924 RS04965
gene id: 1121353:H924_RS04965
uniprot id: M1UEG0
names: Similarity
messages: Belongs to the PrpD family.

1121353:H924 RS04530
gene id: 1121353:H924_RS04530
uniprot id: M1UK91
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1121353:H924 RS08420
gene id: 1121353:H924_RS08420
uniprot id: M1UZE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1121353:H924 RS05920
gene id: 1121353:H924_RS05920
uniprot id: M1UYK7
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1121353:H924 RS00955
gene id: 1121353:H924_RS00955
uniprot id: M1UIS1
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS02625
gene id: 1121353:H924_RS02625
uniprot id: M1UJI6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1121353:H924 RS02525
gene id: 1121353:H924_RS02525
uniprot id: M1UJH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1121353:H924 RS08300
gene id: 1121353:H924_RS08300
uniprot id: M1ULT7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1121353:H924 RS11475
gene id: 1121353:H924_RS11475
uniprot id: M1UH57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

1121353:H924 RS12995
gene id: 1121353:H924_RS12995
uniprot id: M1UHV5
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS11020
gene id: 1121353:H924_RS11020
uniprot id: M1V059
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1121353:H924 RS01520
gene id: 1121353:H924_RS01520
uniprot id: M1URR9
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

1121353:H924 RS13030
gene id: 1121353:H924_RS13030
uniprot id: M1UWG1
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

1121353:H924 RS05430
gene id: 1121353:H924_RS05430
uniprot id: M1TQ94
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1121353:H924 RS08665
gene id: 1121353:H924_RS08665
uniprot id: M1TSC1
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1121353:H924 RS03455
gene id: 1121353:H924_RS03455
uniprot id: M1USM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpqB lipoprotein family.
messages: Cell membrane

1121353:H924 RS09685
gene id: 1121353:H924_RS09685
uniprot id: M1UMF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

1121353:H924 RS12165
gene id: 1121353:H924_RS12165
uniprot id: M1UHH0
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS09995
gene id: 1121353:H924_RS09995
uniprot id: M1UVF6
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1121353:H924 RS05395
gene id: 1121353:H924_RS05395
uniprot id: M1UKN9
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS11900
gene id: 1121353:H924_RS11900
uniprot id: M1UW06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1121353:H924 RS08395
gene id: 1121353:H924_RS08395
uniprot id: M1UZD7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1121353:H924 RS05875
gene id: 1121353:H924_RS05875
uniprot id: M1UKV0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1121353:H924 RS01805
gene id: 1121353:H924_RS01805
uniprot id: M1UJ35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyltransferase group 1 family. MshA subfamily.
messages: Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
messages: Homodimer.

1121353:H924 RS05840
gene id: 1121353:H924_RS05840
uniprot id: M1UTR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

1121353:H924 RS07560
gene id: 1121353:H924_RS07560
uniprot id: M1UFJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

1121353:H924 RS00825
gene id: 1121353:H924_RS00825
uniprot id: M1UWY7
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1121353:H924 RS02600
gene id: 1121353:H924_RS02600
uniprot id: M1UJI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1121353:H924 RS11500
gene id: 1121353:H924_RS11500
uniprot id: M1UH60
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1121353:H924 RS01605
gene id: 1121353:H924_RS01605
uniprot id: M1UX71
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1121353:H924 RS12285
gene id: 1121353:H924_RS12285
uniprot id: M1UHJ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

1121353:H924 RS12600
gene id: 1121353:H924_RS12600
uniprot id: M1UNU2
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS01220
gene id: 1121353:H924_RS01220
uniprot id: M1UCS6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1121353:H924 RS10615
gene id: 1121353:H924_RS10615
uniprot id: M1UVM1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1121353:H924 RS10450
gene id: 1121353:H924_RS10450
uniprot id: M1TTI1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

1121353:H924 RS00415
gene id: 1121353:H924_RS00415
uniprot id: M1UCH1
names: Subcellular Location Annotation
messages: Membrane

1121353:H924 RS01830
gene id: 1121353:H924_RS01830
uniprot id: M1UJ39
names: Subcellular Location Annotation
messages: Membrane