111015:AXF14 RS07180
gene id: 111015:AXF14_RS07180
uniprot id: A0A0X8JFC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

111015:AXF14 RS10965
gene id: 111015:AXF14_RS10965
uniprot id: A0A0X8JFP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

111015:AXF14 RS00800
gene id: 111015:AXF14_RS00800
uniprot id: A0A0X8JCJ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

111015:AXF14 RS11070
gene id: 111015:AXF14_RS11070
uniprot id: A0A0X8JFQ0
names: Similarity
messages: Belongs to the YciI family.

111015:AXF14 RS10745
gene id: 111015:AXF14_RS10745
uniprot id: A0A120KLM0
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS07735
gene id: 111015:AXF14_RS07735
uniprot id: A0A0X8JFJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

111015:AXF14 RS09865
gene id: 111015:AXF14_RS09865
uniprot id: A0A0X8JFD4
names: Similarity
messages: Belongs to the Nudix hydrolase family.

111015:AXF14 RS07315
gene id: 111015:AXF14_RS07315
uniprot id: A0A0X8JEL6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

111015:AXF14 RS07155
gene id: 111015:AXF14_RS07155
uniprot id: A0A0X8JEK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

111015:AXF14 RS05070
gene id: 111015:AXF14_RS05070
uniprot id: A0A109W7K6
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS08090
gene id: 111015:AXF14_RS08090
uniprot id: A0A0X8JEV5
names: Similarity
messages: Belongs to the peptidase M24B family.

111015:AXF14 RS10735
gene id: 111015:AXF14_RS10735
uniprot id: A0A120KLE5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

111015:AXF14 RS12550
gene id: 111015:AXF14_RS12550
uniprot id: A0A0X8JGK8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

111015:AXF14 RS07925
gene id: 111015:AXF14_RS07925
uniprot id: A0A0X8JF76
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS12615
gene id: 111015:AXF14_RS12615
uniprot id: A0A109W3F1
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS09710
gene id: 111015:AXF14_RS09710
uniprot id: A0A0X8JG73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

111015:AXF14 RS01145
gene id: 111015:AXF14_RS01145
uniprot id: A0A0X8JD96
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS07700
gene id: 111015:AXF14_RS07700
uniprot id: A0A0X8JEQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

111015:AXF14 RS05710
gene id: 111015:AXF14_RS05710
uniprot id: A0A0X8JE47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

111015:AXF14 RS11980
gene id: 111015:AXF14_RS11980
uniprot id: A0A0X8JGL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

111015:AXF14 RS02665
gene id: 111015:AXF14_RS02665
uniprot id: A0A120KMR1
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

111015:AXF14 RS11915
gene id: 111015:AXF14_RS11915
uniprot id: A0A0X8JGG6
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

111015:AXF14 RS07380
gene id: 111015:AXF14_RS07380
uniprot id: A0A120KL66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.

111015:AXF14 RS09240
gene id: 111015:AXF14_RS09240
uniprot id: A0A0X8JF77
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

111015:AXF14 RS08910
gene id: 111015:AXF14_RS08910
uniprot id: A0A109W2U2
names: Similarity
messages: Belongs to the ribF family.

111015:AXF14 RS00955
gene id: 111015:AXF14_RS00955
uniprot id: A0A0X8JCM7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

111015:AXF14 RS03130
gene id: 111015:AXF14_RS03130
uniprot id: A0A0X8JDW6
names: Similarity
messages: Belongs to the universal stress protein A family.

111015:AXF14 RS12730
gene id: 111015:AXF14_RS12730
uniprot id: A0A120KLH6
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

111015:AXF14 RS04495
gene id: 111015:AXF14_RS04495
uniprot id: A0A0X8JDR2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

111015:AXF14 RS11800
gene id: 111015:AXF14_RS11800
uniprot id: A0A0X8JFX8
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

111015:AXF14 RS12625
gene id: 111015:AXF14_RS12625
uniprot id: A0A109W379
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS11085
gene id: 111015:AXF14_RS11085
uniprot id: A0A0X8JGC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

111015:AXF14 RS06805
gene id: 111015:AXF14_RS06805
uniprot id: A0A0X8JF12
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

111015:AXF14 RS09920
gene id: 111015:AXF14_RS09920
uniprot id: A0A0X8JFT4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

111015:AXF14 RS07250
gene id: 111015:AXF14_RS07250
uniprot id: A0A0X8JF69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

111015:AXF14 RS00900
gene id: 111015:AXF14_RS00900
uniprot id: A0A0X8JGD2
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS07415
gene id: 111015:AXF14_RS07415
uniprot id: A0A0X8JEN9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

111015:AXF14 RS04995
gene id: 111015:AXF14_RS04995
uniprot id: A0A120KLC7
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

111015:AXF14 RS11630
gene id: 111015:AXF14_RS11630
uniprot id: A0A0X8JGB1
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS01345
gene id: 111015:AXF14_RS01345
uniprot id: A0A0X8JDJ8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

111015:AXF14 RS08750
gene id: 111015:AXF14_RS08750
uniprot id: A0A0X8JFP1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS06310
gene id: 111015:AXF14_RS06310
uniprot id: A0A0X8JEB6
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.

111015:AXF14 RS00760
gene id: 111015:AXF14_RS00760
uniprot id: A0A0X8JD79
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

111015:AXF14 RS08240
gene id: 111015:AXF14_RS08240
uniprot id: A0A120KMK5
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS03180
gene id: 111015:AXF14_RS03180
uniprot id: A0A0X8JDB0
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

111015:AXF14 RS04050
gene id: 111015:AXF14_RS04050
uniprot id: A0A109W1X7
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

111015:AXF14 RS06145
gene id: 111015:AXF14_RS06145
uniprot id: A0A120KL47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

111015:AXF14 RS08950
gene id: 111015:AXF14_RS08950
uniprot id: A0A0X8JFI4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

111015:AXF14 RS09450
gene id: 111015:AXF14_RS09450
uniprot id: A0A109W2X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

111015:AXF14 RS00435
gene id: 111015:AXF14_RS00435
uniprot id: A0A0X8JD27
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

111015:AXF14 RS05420
gene id: 111015:AXF14_RS05420
uniprot id: A0A0X8JEG5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS03055
gene id: 111015:AXF14_RS03055
uniprot id: A0A0X8JD99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Cell membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

111015:AXF14 RS12740
gene id: 111015:AXF14_RS12740
uniprot id: A0A120KLQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

111015:AXF14 RS03235
gene id: 111015:AXF14_RS03235
uniprot id: A0A0X8JDY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

111015:AXF14 RS08735
gene id: 111015:AXF14_RS08735
uniprot id: A0A0X8JF22
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

111015:AXF14 RS07830
gene id: 111015:AXF14_RS07830
uniprot id: A0A0X8JF66
names: Similarity
messages: Belongs to the acylphosphatase family.

111015:AXF14 RS11535
gene id: 111015:AXF14_RS11535
uniprot id: A0A0X8JFV9
names: Function
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.

111015:AXF14 RS11335
gene id: 111015:AXF14_RS11335
uniprot id: A0A0X8JFT8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

111015:AXF14 RS08680
gene id: 111015:AXF14_RS08680
uniprot id: A0A0X8JGS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

111015:AXF14 RS04985
gene id: 111015:AXF14_RS04985
uniprot id: A0A120KL27
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

111015:AXF14 RS06120
gene id: 111015:AXF14_RS06120
uniprot id: A0A0X8JEN6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS03145
gene id: 111015:AXF14_RS03145
uniprot id: A0A109W287
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

111015:AXF14 RS07305
gene id: 111015:AXF14_RS07305
uniprot id: A0A120KL69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

111015:AXF14 RS03005
gene id: 111015:AXF14_RS03005
uniprot id: A0A0X8JD97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

111015:AXF14 RS01805
gene id: 111015:AXF14_RS01805
uniprot id: A0A0X8JDJ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

111015:AXF14 RS07360
gene id: 111015:AXF14_RS07360
uniprot id: A0A0X8JEM0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

111015:AXF14 RS10510
gene id: 111015:AXF14_RS10510
uniprot id: A0A0X8JFL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

111015:AXF14 RS07090
gene id: 111015:AXF14_RS07090
uniprot id: A0A0X8JEY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS02390
gene id: 111015:AXF14_RS02390
uniprot id: A0A0X8JDU1
names: Similarity
messages: Belongs to the peptidase M18 family.

111015:AXF14 RS00245
gene id: 111015:AXF14_RS00245
uniprot id: A0A109W1Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

111015:AXF14 RS00985
gene id: 111015:AXF14_RS00985
uniprot id: A0A109W216
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

111015:AXF14 RS04300
gene id: 111015:AXF14_RS04300
uniprot id: A0A109W2C6
names: Similarity
messages: Belongs to the CsoR family.

111015:AXF14 RS07230
gene id: 111015:AXF14_RS07230
uniprot id: A0A0X8JEL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

111015:AXF14 RS01935
gene id: 111015:AXF14_RS01935
uniprot id: A0A0X8JCX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

111015:AXF14 RS07120
gene id: 111015:AXF14_RS07120
uniprot id: A0A120KL59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

111015:AXF14 RS07460
gene id: 111015:AXF14_RS07460
uniprot id: A0A0X8JEN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

111015:AXF14 RS08920
gene id: 111015:AXF14_RS08920
uniprot id: A0A0X8JF39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

111015:AXF14 RS12665
gene id: 111015:AXF14_RS12665
uniprot id: A0A0X8JG81
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS05165
gene id: 111015:AXF14_RS05165
uniprot id: A0A109W2G2
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

111015:AXF14 RS08760
gene id: 111015:AXF14_RS08760
uniprot id: A0A0X8JFG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

111015:AXF14 RS10640
gene id: 111015:AXF14_RS10640
uniprot id: A0A109W302
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

111015:AXF14 RS02690
gene id: 111015:AXF14_RS02690
uniprot id: A0A0X8JD75
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

111015:AXF14 RS11925
gene id: 111015:AXF14_RS11925
uniprot id: A0A0X8JHQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

111015:AXF14 RS11555
gene id: 111015:AXF14_RS11555
uniprot id: A0A0X8JGH5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

111015:AXF14 RS09525
gene id: 111015:AXF14_RS09525
uniprot id: A0A0X8JHB7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS01520
gene id: 111015:AXF14_RS01520
uniprot id: A0A0X8JCT9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

111015:AXF14 RS04065
gene id: 111015:AXF14_RS04065
uniprot id: A0A0X8JDK6
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS01070
gene id: 111015:AXF14_RS01070
uniprot id: A0A0X8JDB2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

111015:AXF14 RS03155
gene id: 111015:AXF14_RS03155
uniprot id: A0A109W290
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

111015:AXF14 RS11930
gene id: 111015:AXF14_RS11930
uniprot id: A0A120KMP4
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS08345
gene id: 111015:AXF14_RS08345
uniprot id: A0A0X8JEX7
names: Similarity
messages: Belongs to the FPG family.

111015:AXF14 RS01335
gene id: 111015:AXF14_RS01335
uniprot id: A0A0X8JCQ4
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

111015:AXF14 RS08995
gene id: 111015:AXF14_RS08995
uniprot id: A0A109W2V7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

111015:AXF14 RS01600
gene id: 111015:AXF14_RS01600
uniprot id: A0A0X8JDE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS09150
gene id: 111015:AXF14_RS09150
uniprot id: A0A0X8JFL0
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS06170
gene id: 111015:AXF14_RS06170
uniprot id: A0A0X8JE93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

111015:AXF14 RS03400
gene id: 111015:AXF14_RS03400
uniprot id: A0A0X8JDD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

111015:AXF14 RS06725
gene id: 111015:AXF14_RS06725
uniprot id: A0A109W2M0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

111015:AXF14 RS10120
gene id: 111015:AXF14_RS10120
uniprot id: A0A0X8JGB7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.
messages: Cell membrane
messages: Contains a di-nuclear catalytic Mg(2+) center.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

111015:AXF14 RS06110
gene id: 111015:AXF14_RS06110
uniprot id: A0A0X8JEU4
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS14405
gene id: 111015:AXF14_RS14405
uniprot id: A0A120KL20
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS06275
gene id: 111015:AXF14_RS06275
uniprot id: A0A0X8JEB1
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

111015:AXF14 RS07855
gene id: 111015:AXF14_RS07855
uniprot id: A0A120KL81
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

111015:AXF14 RS12370
gene id: 111015:AXF14_RS12370
uniprot id: A0A0X8JGI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

111015:AXF14 RS05010
gene id: 111015:AXF14_RS05010
uniprot id: A0A0X8JDW9
names: Similarity
messages: Belongs to the thioesterase PaaI family.

111015:AXF14 RS14735
gene id: 111015:AXF14_RS14735
uniprot id: A0A0X8JEL2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

111015:AXF14 RS00100
gene id: 111015:AXF14_RS00100
uniprot id: A0A0X8JCZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

111015:AXF14 RS06085
gene id: 111015:AXF14_RS06085
uniprot id: A0A0X8JE83
names: Similarity
messages: Belongs to the cytochrome c-552 family.

111015:AXF14 RS00320
gene id: 111015:AXF14_RS00320
uniprot id: A0A0X8JD17
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

111015:AXF14 RS04415
gene id: 111015:AXF14_RS04415
uniprot id: A0A0X8JDP7
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

111015:AXF14 RS02560
gene id: 111015:AXF14_RS02560
uniprot id: A0A0X8JDP8
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.

111015:AXF14 RS07480
gene id: 111015:AXF14_RS07480
uniprot id: A0A109W2N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS00570
gene id: 111015:AXF14_RS00570
uniprot id: A0A109W1Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

111015:AXF14 RS08830
gene id: 111015:AXF14_RS08830
uniprot id: A0A0X8JF32
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

111015:AXF14 RS04575
gene id: 111015:AXF14_RS04575
uniprot id: A0A109W2E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

111015:AXF14 RS12095
gene id: 111015:AXF14_RS12095
uniprot id: A0A109W368
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS09355
gene id: 111015:AXF14_RS09355
uniprot id: A0A109W2W6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

111015:AXF14 RS08280
gene id: 111015:AXF14_RS08280
uniprot id: A0A0X8JEX6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

111015:AXF14 RS03375
gene id: 111015:AXF14_RS03375
uniprot id: A0A0X8JDX0
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

111015:AXF14 RS03140
gene id: 111015:AXF14_RS03140
uniprot id: A0A109W291
names: Similarity
messages: Belongs to the peptidase C40 family.

111015:AXF14 RS08395
gene id: 111015:AXF14_RS08395
uniprot id: A0A0X8JFD1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

111015:AXF14 RS00155
gene id: 111015:AXF14_RS00155
uniprot id: A0A0X8JCG4
names: Similarity
messages: Belongs to the DapA family.

111015:AXF14 RS06295
gene id: 111015:AXF14_RS06295
uniprot id: A0A0X8JEW0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

111015:AXF14 RS04535
gene id: 111015:AXF14_RS04535
uniprot id: A0A0X8JEJ1
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS05590
gene id: 111015:AXF14_RS05590
uniprot id: A0A0X8JE39
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

111015:AXF14 RS09045
gene id: 111015:AXF14_RS09045
uniprot id: A0A0X8JFS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

111015:AXF14 RS08140
gene id: 111015:AXF14_RS08140
uniprot id: A0A109W2S6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

111015:AXF14 RS01155
gene id: 111015:AXF14_RS01155
uniprot id: A0A109W215
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

111015:AXF14 RS09330
gene id: 111015:AXF14_RS09330
uniprot id: A0A120KLB3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

111015:AXF14 RS11790
gene id: 111015:AXF14_RS11790
uniprot id: A0A0X8JFX3
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

111015:AXF14 RS05665
gene id: 111015:AXF14_RS05665
uniprot id: A0A109W2H0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

111015:AXF14 RS01905
gene id: 111015:AXF14_RS01905
uniprot id: A0A0X8JDK2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

111015:AXF14 RS01825
gene id: 111015:AXF14_RS01825
uniprot id: A0A120KKX7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

111015:AXF14 RS04075
gene id: 111015:AXF14_RS04075
uniprot id: A0A0X8JDK3
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

111015:AXF14 RS04660
gene id: 111015:AXF14_RS04660
uniprot id: A0A0X8JE92
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS10430
gene id: 111015:AXF14_RS10430
uniprot id: A0A0X8JG07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

111015:AXF14 RS11105
gene id: 111015:AXF14_RS11105
uniprot id: A0A0X8JFS2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS02620
gene id: 111015:AXF14_RS02620
uniprot id: A0A0X8JD51
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

111015:AXF14 RS02220
gene id: 111015:AXF14_RS02220
uniprot id: A0A120KKX5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS02705
gene id: 111015:AXF14_RS02705
uniprot id: A0A0X8JD48
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS00935
gene id: 111015:AXF14_RS00935
uniprot id: A0A0X8JDI6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

111015:AXF14 RS04055
gene id: 111015:AXF14_RS04055
uniprot id: A0A0X8JDJ2
names: Similarity
messages: Belongs to the peptidase S8 family.

111015:AXF14 RS03340
gene id: 111015:AXF14_RS03340
uniprot id: A0A109W2A1
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS08035
gene id: 111015:AXF14_RS08035
uniprot id: A0A109W2R0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

111015:AXF14 RS09440
gene id: 111015:AXF14_RS09440
uniprot id: A0A109W2W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

111015:AXF14 RS11970
gene id: 111015:AXF14_RS11970
uniprot id: A0A0X8JG12
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS01875
gene id: 111015:AXF14_RS01875
uniprot id: A0A0X8JDH9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

111015:AXF14 RS11295
gene id: 111015:AXF14_RS11295
uniprot id: A0A109W337
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Membrane

111015:AXF14 RS02030
gene id: 111015:AXF14_RS02030
uniprot id: A0A109W244
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

111015:AXF14 RS04090
gene id: 111015:AXF14_RS04090
uniprot id: A0A0X8JE88
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

111015:AXF14 RS05835
gene id: 111015:AXF14_RS05835
uniprot id: A0A0X8JE67
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

111015:AXF14 RS08410
gene id: 111015:AXF14_RS08410
uniprot id: A0A109W2T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

111015:AXF14 RS06250
gene id: 111015:AXF14_RS06250
uniprot id: A0A109W2K1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

111015:AXF14 RS12845
gene id: 111015:AXF14_RS12845
uniprot id: A0A109W383
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS01105
gene id: 111015:AXF14_RS01105
uniprot id: A0A0X8JCP9
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

111015:AXF14 RS05650
gene id: 111015:AXF14_RS05650
uniprot id: A0A109W7M4
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

111015:AXF14 RS02270
gene id: 111015:AXF14_RS02270
uniprot id: A0A0X8JD03
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

111015:AXF14 RS07680
gene id: 111015:AXF14_RS07680
uniprot id: A0A109W3E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

111015:AXF14 RS07685
gene id: 111015:AXF14_RS07685
uniprot id: A0A120KMJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

111015:AXF14 RS07510
gene id: 111015:AXF14_RS07510
uniprot id: A0A0X8JEP2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

111015:AXF14 RS02745
gene id: 111015:AXF14_RS02745
uniprot id: A0A109W3B0
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

111015:AXF14 RS07420
gene id: 111015:AXF14_RS07420
uniprot id: A0A0X8JEN7
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

111015:AXF14 RS09895
gene id: 111015:AXF14_RS09895
uniprot id: A0A0X8JFD6
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

111015:AXF14 RS10620
gene id: 111015:AXF14_RS10620
uniprot id: A0A109W2Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS04015
gene id: 111015:AXF14_RS04015
uniprot id: A0A109W2C1
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS01440
gene id: 111015:AXF14_RS01440
uniprot id: A0A0X8JCS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

111015:AXF14 RS10615
gene id: 111015:AXF14_RS10615
uniprot id: A0A0X8JFM3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

111015:AXF14 RS12830
gene id: 111015:AXF14_RS12830
uniprot id: A0A109W8E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS07525
gene id: 111015:AXF14_RS07525
uniprot id: A0A0X8JH84
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

111015:AXF14 RS11635
gene id: 111015:AXF14_RS11635
uniprot id: A0A0X8JGI4
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS00535
gene id: 111015:AXF14_RS00535
uniprot id: A0A120KLI2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

111015:AXF14 RS06105
gene id: 111015:AXF14_RS06105
uniprot id: A0A0X8JEN5
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS11065
gene id: 111015:AXF14_RS11065
uniprot id: A0A0X8JFQ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

111015:AXF14 RS08855
gene id: 111015:AXF14_RS08855
uniprot id: A0A0X8JFI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

111015:AXF14 RS01925
gene id: 111015:AXF14_RS01925
uniprot id: A0A109W245
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

111015:AXF14 RS07135
gene id: 111015:AXF14_RS07135
uniprot id: A0A120KMI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

111015:AXF14 RS03660
gene id: 111015:AXF14_RS03660
uniprot id: A0A0X8JDF6
names: Similarity
messages: Belongs to the catalase family.

111015:AXF14 RS01430
gene id: 111015:AXF14_RS01430
uniprot id: A0A0X8JDN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

111015:AXF14 RS09485
gene id: 111015:AXF14_RS09485
uniprot id: A0A0X8JFA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS12380
gene id: 111015:AXF14_RS12380
uniprot id: A0A0X8JG71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

111015:AXF14 RS08365
gene id: 111015:AXF14_RS08365
uniprot id: A0A0X8JEY6
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

111015:AXF14 RS01665
gene id: 111015:AXF14_RS01665
uniprot id: A0A0X8JDN7
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

111015:AXF14 RS07375
gene id: 111015:AXF14_RS07375
uniprot id: A0A0X8JGP5
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

111015:AXF14 RS08795
gene id: 111015:AXF14_RS08795
uniprot id: A0A109W7Y7
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

111015:AXF14 RS06315
gene id: 111015:AXF14_RS06315
uniprot id: A0A109W2J7
names: Similarity
messages: Belongs to the HIBADH-related family.

111015:AXF14 RS07225
gene id: 111015:AXF14_RS07225
uniprot id: A0A0X8JEK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

111015:AXF14 RS00875
gene id: 111015:AXF14_RS00875
uniprot id: A0A0X8JH70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

111015:AXF14 RS07345
gene id: 111015:AXF14_RS07345
uniprot id: A0A0X8JF79
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

111015:AXF14 RS07190
gene id: 111015:AXF14_RS07190
uniprot id: A0A0X8JEK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

111015:AXF14 RS11730
gene id: 111015:AXF14_RS11730
uniprot id: A0A0X8JGJ2
names: Similarity
messages: Belongs to the carbamate kinase family.

111015:AXF14 RS09965
gene id: 111015:AXF14_RS09965
uniprot id: A0A0X8JFD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS07280
gene id: 111015:AXF14_RS07280
uniprot id: A0A109W2P1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

111015:AXF14 RS10750
gene id: 111015:AXF14_RS10750
uniprot id: A0A0X8JGU7
names: Similarity
messages: Belongs to the ABC transporter superfamily.

111015:AXF14 RS09375
gene id: 111015:AXF14_RS09375
uniprot id: A0A0X8JF92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

111015:AXF14 RS11000
gene id: 111015:AXF14_RS11000
uniprot id: A0A0X8JFR2
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

111015:AXF14 RS12835
gene id: 111015:AXF14_RS12835
uniprot id: A0A120KMQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS09205
gene id: 111015:AXF14_RS09205
uniprot id: A0A0X8JF73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

111015:AXF14 RS08925
gene id: 111015:AXF14_RS08925
uniprot id: A0A0X8JF45
names: Similarity
messages: Belongs to the peptidase M16 family.

111015:AXF14 RS01605
gene id: 111015:AXF14_RS01605
uniprot id: A0A0X8JCU8
names: Similarity
messages: Belongs to the ABC transporter superfamily.

111015:AXF14 RS08025
gene id: 111015:AXF14_RS08025
uniprot id: A0A0X8JF93
names: Similarity
messages: Belongs to the LOG family.

111015:AXF14 RS12715
gene id: 111015:AXF14_RS12715
uniprot id: A0A109W384
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

111015:AXF14 RS00060
gene id: 111015:AXF14_RS00060
uniprot id: A0A120KKU6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

111015:AXF14 RS10550
gene id: 111015:AXF14_RS10550
uniprot id: A0A109W308
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

111015:AXF14 RS03940
gene id: 111015:AXF14_RS03940
uniprot id: A0A0X8JDK5
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.

111015:AXF14 RS12645
gene id: 111015:AXF14_RS12645
uniprot id: A0A0X8JG80
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

111015:AXF14 RS01240
gene id: 111015:AXF14_RS01240
uniprot id: A0A0X8JGE5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

111015:AXF14 RS05390
gene id: 111015:AXF14_RS05390
uniprot id: A0A0X8JE21
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

111015:AXF14 RS11090
gene id: 111015:AXF14_RS11090
uniprot id: A0A0X8JGJ8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

111015:AXF14 RS00880
gene id: 111015:AXF14_RS00880
uniprot id: A0A109W208
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

111015:AXF14 RS07705
gene id: 111015:AXF14_RS07705
uniprot id: A0A0X8JER9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

111015:AXF14 RS10435
gene id: 111015:AXF14_RS10435
uniprot id: A0A109W309
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

111015:AXF14 RS13810
gene id: 111015:AXF14_RS13810
uniprot id: A0A109W1Z9
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

111015:AXF14 RS09980
gene id: 111015:AXF14_RS09980
uniprot id: A0A0X8JFF0
names: Similarity
messages: Belongs to the glutamine synthetase family.

111015:AXF14 RS00350
gene id: 111015:AXF14_RS00350
uniprot id: A0A120KKV4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

111015:AXF14 RS12185
gene id: 111015:AXF14_RS12185
uniprot id: A0A0X8JGI3
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

111015:AXF14 RS10420
gene id: 111015:AXF14_RS10420
uniprot id: A0A0X8JFK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

111015:AXF14 RS10515
gene id: 111015:AXF14_RS10515
uniprot id: A0A120KLD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

111015:AXF14 RS09350
gene id: 111015:AXF14_RS09350
uniprot id: A0A120KML1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

111015:AXF14 RS03095
gene id: 111015:AXF14_RS03095
uniprot id: A0A0X8JDZ6
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

111015:AXF14 RS01535
gene id: 111015:AXF14_RS01535
uniprot id: A0A109W236
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

111015:AXF14 RS06220
gene id: 111015:AXF14_RS06220
uniprot id: A0A0X8JEA6
names: Similarity
messages: Belongs to the SAICAR synthetase family.

111015:AXF14 RS01760
gene id: 111015:AXF14_RS01760
uniprot id: A0A0X8JCV5
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

111015:AXF14 RS10415
gene id: 111015:AXF14_RS10415
uniprot id: A0A0X8JFY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS08300
gene id: 111015:AXF14_RS08300
uniprot id: A0A0X8JFC1
names: Similarity
messages: Belongs to the disproportionating enzyme family.

111015:AXF14 RS07200
gene id: 111015:AXF14_RS07200
uniprot id: A0A0X8JF40
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

111015:AXF14 RS07570
gene id: 111015:AXF14_RS07570
uniprot id: A0A0X8JF74
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS09530
gene id: 111015:AXF14_RS09530
uniprot id: A0A0X8JFP7
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

111015:AXF14 RS05380
gene id: 111015:AXF14_RS05380
uniprot id: A0A0X8JE20
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS12870
gene id: 111015:AXF14_RS12870
uniprot id: A0A0X8JH99
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS00805
gene id: 111015:AXF14_RS00805
uniprot id: A0A0X8JCL4
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

111015:AXF14 RS03250
gene id: 111015:AXF14_RS03250
uniprot id: A0A120KL00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

111015:AXF14 RS11350
gene id: 111015:AXF14_RS11350
uniprot id: A0A0X8JG82
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS11820
gene id: 111015:AXF14_RS11820
uniprot id: A0A0X8JGT7
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS01530
gene id: 111015:AXF14_RS01530
uniprot id: A0A0X8JDG4
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

111015:AXF14 RS07215
gene id: 111015:AXF14_RS07215
uniprot id: A0A109W2N5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

111015:AXF14 RS06195
gene id: 111015:AXF14_RS06195
uniprot id: A0A0X8JEA1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

111015:AXF14 RS07515
gene id: 111015:AXF14_RS07515
uniprot id: A0A0X8JEP8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

111015:AXF14 RS13610
gene id: 111015:AXF14_RS13610
uniprot id: A0A109W3B4
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

111015:AXF14 RS07965
gene id: 111015:AXF14_RS07965
uniprot id: A0A109W2R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS04010
gene id: 111015:AXF14_RS04010
uniprot id: A0A0X8JE60
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS11420
gene id: 111015:AXF14_RS11420
uniprot id: A0A109W890
names: Similarity
messages: Belongs to the UPF0098 family.

111015:AXF14 RS10935
gene id: 111015:AXF14_RS10935
uniprot id: A0A109W316
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

111015:AXF14 RS01030
gene id: 111015:AXF14_RS01030
uniprot id: A0A0X8JD89
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

111015:AXF14 RS07785
gene id: 111015:AXF14_RS07785
uniprot id: A0A109W2Q4
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

111015:AXF14 RS04845
gene id: 111015:AXF14_RS04845
uniprot id: A0A0X8JEG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

111015:AXF14 RS00310
gene id: 111015:AXF14_RS00310
uniprot id: A0A0X8JDC1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

111015:AXF14 RS07780
gene id: 111015:AXF14_RS07780
uniprot id: A0A109W2Q1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

111015:AXF14 RS11010
gene id: 111015:AXF14_RS11010
uniprot id: A0A0X8JG66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

111015:AXF14 RS10920
gene id: 111015:AXF14_RS10920
uniprot id: A0A0X8JG55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

111015:AXF14 RS12815
gene id: 111015:AXF14_RS12815
uniprot id: A0A0X8JGA7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

111015:AXF14 RS07950
gene id: 111015:AXF14_RS07950
uniprot id: A0A109W7V6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

111015:AXF14 RS10560
gene id: 111015:AXF14_RS10560
uniprot id: A0A109W306
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

111015:AXF14 RS09775
gene id: 111015:AXF14_RS09775
uniprot id: A0A0X8JFC3
names: Similarity
messages: Belongs to the CdaR family.

111015:AXF14 RS07350
gene id: 111015:AXF14_RS07350
uniprot id: A0A0X8JFF3
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

111015:AXF14 RS09420
gene id: 111015:AXF14_RS09420
uniprot id: A0A109W2V8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

111015:AXF14 RS02675
gene id: 111015:AXF14_RS02675
uniprot id: A0A120KKZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

111015:AXF14 RS10605
gene id: 111015:AXF14_RS10605
uniprot id: A0A0X8JGG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

111015:AXF14 RS00815
gene id: 111015:AXF14_RS00815
uniprot id: A0A0X8JCK4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

111015:AXF14 RS05250
gene id: 111015:AXF14_RS05250
uniprot id: A0A0X8JEJ7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS06075
gene id: 111015:AXF14_RS06075
uniprot id: A0A109W2J5
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

111015:AXF14 RS09155
gene id: 111015:AXF14_RS09155
uniprot id: A0A109W1X7
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

111015:AXF14 RS08560
gene id: 111015:AXF14_RS08560
uniprot id: A0A0X8JFL9
names: Cofactor
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Divalent metal ions. Mg(2+) is the most effective.

111015:AXF14 RS11740
gene id: 111015:AXF14_RS11740
uniprot id: A0A0X8JGC8
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

111015:AXF14 RS04655
gene id: 111015:AXF14_RS04655
uniprot id: A0A0X8JEK1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

111015:AXF14 RS10180
gene id: 111015:AXF14_RS10180
uniprot id: A0A120KLL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

111015:AXF14 RS01490
gene id: 111015:AXF14_RS01490
uniprot id: A0A0X8JCT6
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS06215
gene id: 111015:AXF14_RS06215
uniprot id: A0A0X8JEP7
names: Similarity
messages: Belongs to the GARS family.

111015:AXF14 RS10685
gene id: 111015:AXF14_RS10685
uniprot id: A0A0X8JG87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

111015:AXF14 RS02340
gene id: 111015:AXF14_RS02340
uniprot id: A0A0X8JD29
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

111015:AXF14 RS08370
gene id: 111015:AXF14_RS08370
uniprot id: A0A0X8JFC8
names: Similarity
messages: Belongs to the IMPACT family.

111015:AXF14 RS03105
gene id: 111015:AXF14_RS03105
uniprot id: A0A0X8JDV8
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS01045
gene id: 111015:AXF14_RS01045
uniprot id: A0A0X8JDJ6
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

111015:AXF14 RS06060
gene id: 111015:AXF14_RS06060
uniprot id: A0A109W2J4
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

111015:AXF14 RS07165
gene id: 111015:AXF14_RS07165
uniprot id: A0A0X8JEK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

111015:AXF14 RS10170
gene id: 111015:AXF14_RS10170
uniprot id: A0A120KLD3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

111015:AXF14 RS01900
gene id: 111015:AXF14_RS01900
uniprot id: A0A120KKX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

111015:AXF14 RS01210
gene id: 111015:AXF14_RS01210
uniprot id: A0A0X8JCP1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

111015:AXF14 RS12000
gene id: 111015:AXF14_RS12000
uniprot id: A0A109W350
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

111015:AXF14 RS07505
gene id: 111015:AXF14_RS07505
uniprot id: A0A0X8JEP9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

111015:AXF14 RS10385
gene id: 111015:AXF14_RS10385
uniprot id: A0A0X8JFI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

111015:AXF14 RS09755
gene id: 111015:AXF14_RS09755
uniprot id: A0A109W2X5
names: Similarity
messages: Belongs to the peptidase C56 family.

111015:AXF14 RS10775
gene id: 111015:AXF14_RS10775
uniprot id: A0A0X8JG25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

111015:AXF14 RS08180
gene id: 111015:AXF14_RS08180
uniprot id: A0A0X8JEW7
names: Cofactor
messages: Binds 1 Mg(2+) ion per subunit.

111015:AXF14 RS07195
gene id: 111015:AXF14_RS07195
uniprot id: A0A109W2N0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

111015:AXF14 RS07860
gene id: 111015:AXF14_RS07860
uniprot id: A0A120KL83
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS11795
gene id: 111015:AXF14_RS11795
uniprot id: A0A0X8JFZ2
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

111015:AXF14 RS00140
gene id: 111015:AXF14_RS00140
uniprot id: A0A120KM96
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

111015:AXF14 RS04990
gene id: 111015:AXF14_RS04990
uniprot id: A0A0X8JGJ3
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

111015:AXF14 RS08690
gene id: 111015:AXF14_RS08690
uniprot id: A0A109W2U6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

111015:AXF14 RS03370
gene id: 111015:AXF14_RS03370
uniprot id: A0A0X8JDC9
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.

111015:AXF14 RS12700
gene id: 111015:AXF14_RS12700
uniprot id: A0A0X8JG97
names: Similarity
messages: Belongs to the glycosyl hydrolase.

111015:AXF14 RS08290
gene id: 111015:AXF14_RS08290
uniprot id: A0A0X8JFI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

111015:AXF14 RS04760
gene id: 111015:AXF14_RS04760
uniprot id: A0A109W3C2
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

111015:AXF14 RS08415
gene id: 111015:AXF14_RS08415
uniprot id: A0A0X8JFG5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS09300
gene id: 111015:AXF14_RS09300
uniprot id: A0A0X8JFM5
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS11190
gene id: 111015:AXF14_RS11190
uniprot id: A0A0X8JGL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

111015:AXF14 RS04315
gene id: 111015:AXF14_RS04315
uniprot id: A0A0X8JDM3
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS10480
gene id: 111015:AXF14_RS10480
uniprot id: A0A0X8JFJ5
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

111015:AXF14 RS00700
gene id: 111015:AXF14_RS00700
uniprot id: A0A0X8JCK5
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS00145
gene id: 111015:AXF14_RS00145
uniprot id: A0A109W1Y7
names: Function
names: Similarity
messages: Belongs to the NanE family.
messages: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).

111015:AXF14 RS08270
gene id: 111015:AXF14_RS08270
uniprot id: A0A0X8JEX8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

111015:AXF14 RS09620
gene id: 111015:AXF14_RS09620
uniprot id: A0A120KLB7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

111015:AXF14 RS11620
gene id: 111015:AXF14_RS11620
uniprot id: A0A0X8JFV7
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS11100
gene id: 111015:AXF14_RS11100
uniprot id: A0A0X8JG56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS07915
gene id: 111015:AXF14_RS07915
uniprot id: A0A120KLK2
names: Similarity
messages: Belongs to the BMP lipoprotein family.

111015:AXF14 RS01845
gene id: 111015:AXF14_RS01845
uniprot id: A0A120KL94
names: Similarity
messages: Belongs to the UPF0234 family.

111015:AXF14 RS05305
gene id: 111015:AXF14_RS05305
uniprot id: A0A0X8JE06
names: Function
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

111015:AXF14 RS11125
gene id: 111015:AXF14_RS11125
uniprot id: A0A120KMN6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

111015:AXF14 RS07795
gene id: 111015:AXF14_RS07795
uniprot id: A0A0X8JER6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

111015:AXF14 RS11385
gene id: 111015:AXF14_RS11385
uniprot id: A0A0X8JG88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

111015:AXF14 RS10645
gene id: 111015:AXF14_RS10645
uniprot id: A0A109W303
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

111015:AXF14 RS11645
gene id: 111015:AXF14_RS11645
uniprot id: A0A0X8JGS1
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS00605
gene id: 111015:AXF14_RS00605
uniprot id: A0A0X8JCH5
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

111015:AXF14 RS10035
gene id: 111015:AXF14_RS10035
uniprot id: A0A109W2Y0
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS06000
gene id: 111015:AXF14_RS06000
uniprot id: A0A0X8JE84
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS02695
gene id: 111015:AXF14_RS02695
uniprot id: A0A0X8JD55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

111015:AXF14 RS11545
gene id: 111015:AXF14_RS11545
uniprot id: A0A0X8JFV4
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

111015:AXF14 RS11375
gene id: 111015:AXF14_RS11375
uniprot id: A0A0X8JH93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

111015:AXF14 RS03230
gene id: 111015:AXF14_RS03230
uniprot id: A0A109W285
names: Similarity
messages: Belongs to the WXG100 family.

111015:AXF14 RS14555
gene id: 111015:AXF14_RS14555
uniprot id: A0A0X8JGW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

111015:AXF14 RS08355
gene id: 111015:AXF14_RS08355
uniprot id: A0A0X8JEY8
names: Similarity
messages: Belongs to the peptidase S33 family.

111015:AXF14 RS07890
gene id: 111015:AXF14_RS07890
uniprot id: A0A0X8JET8
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS14695
gene id: 111015:AXF14_RS14695
uniprot id: A0A0X8JDU8
names: Caution
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS06675
gene id: 111015:AXF14_RS06675
uniprot id: A0A0X8JEF0
names: Similarity
messages: Belongs to the universal stress protein A family.

111015:AXF14 RS10790
gene id: 111015:AXF14_RS10790
uniprot id: A0A0X8JGH8
names: Similarity
messages: Belongs to the heat shock protein 70 family.

111015:AXF14 RS09970
gene id: 111015:AXF14_RS09970
uniprot id: A0A0X8JFE7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

111015:AXF14 RS01010
gene id: 111015:AXF14_RS01010
uniprot id: A0A0X8JCM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

111015:AXF14 RS01745
gene id: 111015:AXF14_RS01745
uniprot id: A0A0X8JCV4
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

111015:AXF14 RS07940
gene id: 111015:AXF14_RS07940
uniprot id: A0A0X8JFC2
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

111015:AXF14 RS10825
gene id: 111015:AXF14_RS10825
uniprot id: A0A120KMN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

111015:AXF14 RS10405
gene id: 111015:AXF14_RS10405
uniprot id: A0A0X8JG57
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS02865
gene id: 111015:AXF14_RS02865
uniprot id: A0A109W279
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

111015:AXF14 RS02310
gene id: 111015:AXF14_RS02310
uniprot id: A0A0X8JGS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS02785
gene id: 111015:AXF14_RS02785
uniprot id: A0A0X8JD61
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS01150
gene id: 111015:AXF14_RS01150
uniprot id: A0A0X8JCP7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

111015:AXF14 RS12600
gene id: 111015:AXF14_RS12600
uniprot id: A0A0X8JHB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

111015:AXF14 RS11180
gene id: 111015:AXF14_RS11180
uniprot id: A0A0X8JGD7
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS11765
gene id: 111015:AXF14_RS11765
uniprot id: A0A109W338
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS08625
gene id: 111015:AXF14_RS08625
uniprot id: A0A0X8JF16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS12465
gene id: 111015:AXF14_RS12465
uniprot id: A0A0X8JH09
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

111015:AXF14 RS12430
gene id: 111015:AXF14_RS12430
uniprot id: A0A0X8JG48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

111015:AXF14 RS09445
gene id: 111015:AXF14_RS09445
uniprot id: A0A109W2W5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

111015:AXF14 RS05015
gene id: 111015:AXF14_RS05015
uniprot id: A0A0X8JDX4
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

111015:AXF14 RS06555
gene id: 111015:AXF14_RS06555
uniprot id: A0A109W2L4
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS10425
gene id: 111015:AXF14_RS10425
uniprot id: A0A109W301
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

111015:AXF14 RS07170
gene id: 111015:AXF14_RS07170
uniprot id: A0A0X8JEZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

111015:AXF14 RS12500
gene id: 111015:AXF14_RS12500
uniprot id: A0A109W8D4
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS12100
gene id: 111015:AXF14_RS12100
uniprot id: A0A0X8JGI0
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

111015:AXF14 RS10925
gene id: 111015:AXF14_RS10925
uniprot id: A0A109W310
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

111015:AXF14 RS10520
gene id: 111015:AXF14_RS10520
uniprot id: A0A0X8JG13
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS00165
gene id: 111015:AXF14_RS00165
uniprot id: A0A0X8JCG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

111015:AXF14 RS09110
gene id: 111015:AXF14_RS09110
uniprot id: A0A109W1X7
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

111015:AXF14 RS05340
gene id: 111015:AXF14_RS05340
uniprot id: A0A0X8JE10
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

111015:AXF14 RS04225
gene id: 111015:AXF14_RS04225
uniprot id: A0A0X8JDN4
names: Similarity
messages: Belongs to the RutC family.

111015:AXF14 RS11435
gene id: 111015:AXF14_RS11435
uniprot id: A0A109W334
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

111015:AXF14 RS05945
gene id: 111015:AXF14_RS05945
uniprot id: A0A120KL37
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

111015:AXF14 RS00970
gene id: 111015:AXF14_RS00970
uniprot id: A0A109W209
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

111015:AXF14 RS06800
gene id: 111015:AXF14_RS06800
uniprot id: A0A0X8JEU9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

111015:AXF14 RS09655
gene id: 111015:AXF14_RS09655
uniprot id: A0A109W2X8
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS08640
gene id: 111015:AXF14_RS08640
uniprot id: A0A0X8JFF4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

111015:AXF14 RS07450
gene id: 111015:AXF14_RS07450
uniprot id: A0A0X8JFG2
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

111015:AXF14 RS10995
gene id: 111015:AXF14_RS10995
uniprot id: A0A0X8JG47
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS11715
gene id: 111015:AXF14_RS11715
uniprot id: A0A0X8JFW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS08765
gene id: 111015:AXF14_RS08765
uniprot id: A0A0X8JGR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

111015:AXF14 RS12710
gene id: 111015:AXF14_RS12710
uniprot id: A0A0X8JGN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

111015:AXF14 RS08505
gene id: 111015:AXF14_RS08505
uniprot id: A0A120KMK7
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS01005
gene id: 111015:AXF14_RS01005
uniprot id: A0A0X8JCP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

111015:AXF14 RS05505
gene id: 111015:AXF14_RS05505
uniprot id: A0A109W3B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

111015:AXF14 RS07130
gene id: 111015:AXF14_RS07130
uniprot id: A0A109W7S7
names: Similarity
messages: Belongs to the peptidase A24 family.

111015:AXF14 RS08715
gene id: 111015:AXF14_RS08715
uniprot id: A0A0X8JF19
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

111015:AXF14 RS06175
gene id: 111015:AXF14_RS06175
uniprot id: A0A0X8JEA5
names: Similarity
messages: Belongs to the EfeM/EfeO family.

111015:AXF14 RS09690
gene id: 111015:AXF14_RS09690
uniprot id: A0A0X8JFR8
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

111015:AXF14 RS00345
gene id: 111015:AXF14_RS00345
uniprot id: A0A120KKV1
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

111015:AXF14 RS09315
gene id: 111015:AXF14_RS09315
uniprot id: A0A0X8JFM6
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

111015:AXF14 RS09025
gene id: 111015:AXF14_RS09025
uniprot id: A0A0X8JF49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS09335
gene id: 111015:AXF14_RS09335
uniprot id: A0A0X8JFQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

111015:AXF14 RS10725
gene id: 111015:AXF14_RS10725
uniprot id: A0A109W317
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS00445
gene id: 111015:AXF14_RS00445
uniprot id: A0A120KKU5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

111015:AXF14 RS07845
gene id: 111015:AXF14_RS07845
uniprot id: A0A0X8JFA4
names: Similarity
messages: Belongs to the glycosyl hydrolase 68 family.

111015:AXF14 RS00785
gene id: 111015:AXF14_RS00785
uniprot id: A0A109W204
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS07205
gene id: 111015:AXF14_RS07205
uniprot id: A0A109W2N3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

111015:AXF14 RS04790
gene id: 111015:AXF14_RS04790
uniprot id: A0A109W7J4
names: Similarity
messages: Belongs to the Nudix hydrolase family.

111015:AXF14 RS08620
gene id: 111015:AXF14_RS08620
uniprot id: A0A0X8JF10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

111015:AXF14 RS06025
gene id: 111015:AXF14_RS06025
uniprot id: A0A0X8JEZ4
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS00410
gene id: 111015:AXF14_RS00410
uniprot id: A0A0X8JD28
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

111015:AXF14 RS00560
gene id: 111015:AXF14_RS00560
uniprot id: A0A109W200
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

111015:AXF14 RS06750
gene id: 111015:AXF14_RS06750
uniprot id: A0A120KL55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

111015:AXF14 RS14585
gene id: 111015:AXF14_RS14585
uniprot id: A0A0X8JGA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

111015:AXF14 RS07140
gene id: 111015:AXF14_RS07140
uniprot id: A0A109W2N2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

111015:AXF14 RS04435
gene id: 111015:AXF14_RS04435
uniprot id: A0A0X8JEI2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

111015:AXF14 RS08285
gene id: 111015:AXF14_RS08285
uniprot id: A0A0X8JFB8
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

111015:AXF14 RS00105
gene id: 111015:AXF14_RS00105
uniprot id: A0A0X8JD88
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

111015:AXF14 RS08590
gene id: 111015:AXF14_RS08590
uniprot id: A0A109W2T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

111015:AXF14 RS09760
gene id: 111015:AXF14_RS09760
uniprot id: A0A109W2Y3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

111015:AXF14 RS10110
gene id: 111015:AXF14_RS10110
uniprot id: A0A0X8JFV8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS06720
gene id: 111015:AXF14_RS06720
uniprot id: A0A0X8JEF2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

111015:AXF14 RS12365
gene id: 111015:AXF14_RS12365
uniprot id: A0A0X8JGZ9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

111015:AXF14 RS05410
gene id: 111015:AXF14_RS05410
uniprot id: A0A0X8JE18
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS09935
gene id: 111015:AXF14_RS09935
uniprot id: A0A120KLC3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

111015:AXF14 RS06940
gene id: 111015:AXF14_RS06940
uniprot id: A0A0X8JEW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DisA family.
messages: Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
messages: Homooctamer.
messages: Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.

111015:AXF14 RS09060
gene id: 111015:AXF14_RS09060
uniprot id: A0A0X8JFK0
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

111015:AXF14 RS11890
gene id: 111015:AXF14_RS11890
uniprot id: A0A0X8JGK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

111015:AXF14 RS00770
gene id: 111015:AXF14_RS00770
uniprot id: A0A109W767
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

111015:AXF14 RS10975
gene id: 111015:AXF14_RS10975
uniprot id: A0A0X8JG43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm

111015:AXF14 RS02205
gene id: 111015:AXF14_RS02205
uniprot id: A0A0X8JDV5
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS09415
gene id: 111015:AXF14_RS09415
uniprot id: A0A0X8JF97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS08595
gene id: 111015:AXF14_RS08595
uniprot id: A0A109W2S9
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS04305
gene id: 111015:AXF14_RS04305
uniprot id: A0A0X8JDP1
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS04850
gene id: 111015:AXF14_RS04850
uniprot id: A0A0X8JEM2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

111015:AXF14 RS04245
gene id: 111015:AXF14_RS04245
uniprot id: A0A0X8JDM4
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

111015:AXF14 RS04420
gene id: 111015:AXF14_RS04420
uniprot id: A0A0X8JE63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

111015:AXF14 RS01895
gene id: 111015:AXF14_RS01895
uniprot id: A0A0X8JCX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

111015:AXF14 RS08040
gene id: 111015:AXF14_RS08040
uniprot id: A0A0X8JFD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

111015:AXF14 RS10625
gene id: 111015:AXF14_RS10625
uniprot id: A0A0X8JGU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

111015:AXF14 RS06330
gene id: 111015:AXF14_RS06330
uniprot id: A0A109W2K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

111015:AXF14 RS01075
gene id: 111015:AXF14_RS01075
uniprot id: A0A109W777
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

111015:AXF14 RS07115
gene id: 111015:AXF14_RS07115
uniprot id: A0A0X8JEJ0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

111015:AXF14 RS07185
gene id: 111015:AXF14_RS07185
uniprot id: A0A0X8JEZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

111015:AXF14 RS07220
gene id: 111015:AXF14_RS07220
uniprot id: A0A109W2N6
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

111015:AXF14 RS01380
gene id: 111015:AXF14_RS01380
uniprot id: A0A109W788
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS06240
gene id: 111015:AXF14_RS06240
uniprot id: A0A109W7P7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

111015:AXF14 RS11565
gene id: 111015:AXF14_RS11565
uniprot id: A0A0X8JGX5
names: Cofactor
names: Similarity
messages: Belongs to the class-II DAHP synthase family.
messages: Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.

111015:AXF14 RS12485
gene id: 111015:AXF14_RS12485
uniprot id: A0A0X8JG79
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

111015:AXF14 RS07435
gene id: 111015:AXF14_RS07435
uniprot id: A0A0X8JEN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

111015:AXF14 RS01120
gene id: 111015:AXF14_RS01120
uniprot id: A0A0X8JCN3
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS10280
gene id: 111015:AXF14_RS10280
uniprot id: A0A0X8JFH1
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

111015:AXF14 RS09425
gene id: 111015:AXF14_RS09425
uniprot id: A0A0X8JFR9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta subunits.

111015:AXF14 RS12780
gene id: 111015:AXF14_RS12780
uniprot id: A0A0X8JH41
names: Function
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.

111015:AXF14 RS10260
gene id: 111015:AXF14_RS10260
uniprot id: A0A109W2Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

111015:AXF14 RS10010
gene id: 111015:AXF14_RS10010
uniprot id: A0A109W2X9
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

111015:AXF14 RS08205
gene id: 111015:AXF14_RS08205
uniprot id: A0A0X8JFB2
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

111015:AXF14 RS04440
gene id: 111015:AXF14_RS04440
uniprot id: A0A0X8JE74
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

111015:AXF14 RS10045
gene id: 111015:AXF14_RS10045
uniprot id: A0A109W2Z4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

111015:AXF14 RS02820
gene id: 111015:AXF14_RS02820
uniprot id: A0A0X8JDW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

111015:AXF14 RS07930
gene id: 111015:AXF14_RS07930
uniprot id: A0A0X8JET2
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS07585
gene id: 111015:AXF14_RS07585
uniprot id: A0A109W7M4
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

111015:AXF14 RS11110
gene id: 111015:AXF14_RS11110
uniprot id: A0A120KLE4
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS10500
gene id: 111015:AXF14_RS10500
uniprot id: A0A0X8JGF3
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

111015:AXF14 RS01385
gene id: 111015:AXF14_RS01385
uniprot id: A0A120KMB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

111015:AXF14 RS06385
gene id: 111015:AXF14_RS06385
uniprot id: A0A0X8JER7
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS07410
gene id: 111015:AXF14_RS07410
uniprot id: A0A0X8JEM6
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

111015:AXF14 RS11895
gene id: 111015:AXF14_RS11895
uniprot id: A0A0X8JGV0
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

111015:AXF14 RS05800
gene id: 111015:AXF14_RS05800
uniprot id: A0A0X8JE58
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

111015:AXF14 RS02165
gene id: 111015:AXF14_RS02165
uniprot id: A0A0X8JD11
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS10485
gene id: 111015:AXF14_RS10485
uniprot id: A0A0X8JFZ5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

111015:AXF14 RS12875
gene id: 111015:AXF14_RS12875
uniprot id: A0A0X8JGN4
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

111015:AXF14 RS11975
gene id: 111015:AXF14_RS11975
uniprot id: A0A0X8JGF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Belongs to the TrpC family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

111015:AXF14 RS09460
gene id: 111015:AXF14_RS09460
uniprot id: A0A0X8JFA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

111015:AXF14 RS11055
gene id: 111015:AXF14_RS11055
uniprot id: A0A109W3E6
names: Similarity
messages: Belongs to the UDPGP type 1 family.

111015:AXF14 RS04975
gene id: 111015:AXF14_RS04975
uniprot id: A0A109W2F9
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

111015:AXF14 RS10960
gene id: 111015:AXF14_RS10960
uniprot id: A0A0X8JFP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

111015:AXF14 RS05705
gene id: 111015:AXF14_RS05705
uniprot id: A0A0X8JE48
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

111015:AXF14 RS05865
gene id: 111015:AXF14_RS05865
uniprot id: A0A109W2J1
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS04800
gene id: 111015:AXF14_RS04800
uniprot id: A0A120KMF9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS07270
gene id: 111015:AXF14_RS07270
uniprot id: A0A109W3B8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

111015:AXF14 RS00420
gene id: 111015:AXF14_RS00420
uniprot id: A0A0X8JDD0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

111015:AXF14 RS01255
gene id: 111015:AXF14_RS01255
uniprot id: A0A0X8JDA4
names: Similarity
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Homotrimer.

111015:AXF14 RS06440
gene id: 111015:AXF14_RS06440
uniprot id: A0A120KL51
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS01100
gene id: 111015:AXF14_RS01100
uniprot id: A0A109W219
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

111015:AXF14 RS09065
gene id: 111015:AXF14_RS09065
uniprot id: A0A0X8JF54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

111015:AXF14 RS05030
gene id: 111015:AXF14_RS05030
uniprot id: A0A0X8JEP1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

111015:AXF14 RS04855
gene id: 111015:AXF14_RS04855
uniprot id: A0A0X8JGK0
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS00910
gene id: 111015:AXF14_RS00910
uniprot id: A0A0X8JCK8
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

111015:AXF14 RS08985
gene id: 111015:AXF14_RS08985
uniprot id: A0A109W2V4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

111015:AXF14 RS09940
gene id: 111015:AXF14_RS09940
uniprot id: A0A0X8JFW2
names: Similarity
messages: Belongs to the glutamine synthetase family.

111015:AXF14 RS07025
gene id: 111015:AXF14_RS07025
uniprot id: A0A0X8JEI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

111015:AXF14 RS04805
gene id: 111015:AXF14_RS04805
uniprot id: A0A109W2F2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

111015:AXF14 RS03710
gene id: 111015:AXF14_RS03710
uniprot id: A0A109W2A6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

111015:AXF14 RS07245
gene id: 111015:AXF14_RS07245
uniprot id: A0A0X8JF01
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

111015:AXF14 RS09585
gene id: 111015:AXF14_RS09585
uniprot id: A0A0X8JFA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

111015:AXF14 RS04905
gene id: 111015:AXF14_RS04905
uniprot id: A0A0X8JDW1
names: Similarity
messages: Belongs to the YoeB family.

111015:AXF14 RS08865
gene id: 111015:AXF14_RS08865
uniprot id: A0A109W2T9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

111015:AXF14 RS07790
gene id: 111015:AXF14_RS07790
uniprot id: A0A109W2Q7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

111015:AXF14 RS06735
gene id: 111015:AXF14_RS06735
uniprot id: A0A0X8JEY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

111015:AXF14 RS04155
gene id: 111015:AXF14_RS04155
uniprot id: A0A0X8JDL2
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS07040
gene id: 111015:AXF14_RS07040
uniprot id: A0A109W2N4
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Homodimer.

111015:AXF14 RS07320
gene id: 111015:AXF14_RS07320
uniprot id: A0A0X8JEM7
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

111015:AXF14 RS11770
gene id: 111015:AXF14_RS11770
uniprot id: A0A109W351
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

111015:AXF14 RS10005
gene id: 111015:AXF14_RS10005
uniprot id: A0A0X8JFG3
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

111015:AXF14 RS06165
gene id: 111015:AXF14_RS06165
uniprot id: A0A120KLE6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

111015:AXF14 RS08720
gene id: 111015:AXF14_RS08720
uniprot id: A0A0X8JGR2
names: Similarity
messages: Belongs to the DprA/Smf family.

111015:AXF14 RS02630
gene id: 111015:AXF14_RS02630
uniprot id: A0A0X8JDR1
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

111015:AXF14 RS02555
gene id: 111015:AXF14_RS02555
uniprot id: A0A0X8JDZ9
names: Subcellular Location Annotation
messages: Cytoplasm

111015:AXF14 RS07815
gene id: 111015:AXF14_RS07815
uniprot id: A0A0X8JF62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

111015:AXF14 RS00240
gene id: 111015:AXF14_RS00240
uniprot id: A0A109W1Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

111015:AXF14 RS08545
gene id: 111015:AXF14_RS08545
uniprot id: A0A0X8JF06
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

111015:AXF14 RS02250
gene id: 111015:AXF14_RS02250
uniprot id: A0A109W256
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

111015:AXF14 RS09020
gene id: 111015:AXF14_RS09020
uniprot id: A0A0X8JF55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

111015:AXF14 RS05385
gene id: 111015:AXF14_RS05385
uniprot id: A0A0X8JE23
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

111015:AXF14 RS00470
gene id: 111015:AXF14_RS00470
uniprot id: A0A0X8JH60
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS03415
gene id: 111015:AXF14_RS03415
uniprot id: A0A0X8JDZ5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

111015:AXF14 RS04030
gene id: 111015:AXF14_RS04030
uniprot id: A0A109W2C4
names: Function
names: Similarity
messages: Belongs to the IMPDH/GMPR family. GuaB1 subfamily.
messages: Involved in the purine-salvage pathway. Catalyzes the NADPH-dependent conversion of GMP to IMP.

111015:AXF14 RS06290
gene id: 111015:AXF14_RS06290
uniprot id: A0A0X8JEQ0
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

111015:AXF14 RS08900
gene id: 111015:AXF14_RS08900
uniprot id: A0A109W2U0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

111015:AXF14 RS00045
gene id: 111015:AXF14_RS00045
uniprot id: A0A109W1X7
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

111015:AXF14 RS11410
gene id: 111015:AXF14_RS11410
uniprot id: A0A109W3E8
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

111015:AXF14 RS04680
gene id: 111015:AXF14_RS04680
uniprot id: A0A109W2E7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

111015:AXF14 RS10820
gene id: 111015:AXF14_RS10820
uniprot id: A0A109W868
names: Similarity
messages: Belongs to the peptidase M1 family.

111015:AXF14 RS10785
gene id: 111015:AXF14_RS10785
uniprot id: A0A0X8JG99
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS00635
gene id: 111015:AXF14_RS00635
uniprot id: A0A0X8JDD5
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS00490
gene id: 111015:AXF14_RS00490
uniprot id: A0A0X8JCI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

111015:AXF14 RS10475
gene id: 111015:AXF14_RS10475
uniprot id: A0A0X8JFJ1
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

111015:AXF14 RS07980
gene id: 111015:AXF14_RS07980
uniprot id: A0A0X8JEU7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

111015:AXF14 RS09790
gene id: 111015:AXF14_RS09790
uniprot id: A0A0X8JFD0
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

111015:AXF14 RS05855
gene id: 111015:AXF14_RS05855
uniprot id: A0A0X8JEQ2
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS08695
gene id: 111015:AXF14_RS08695
uniprot id: A0A120KLA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

111015:AXF14 RS12620
gene id: 111015:AXF14_RS12620
uniprot id: A0A109W375
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Membrane

111015:AXF14 RS02425
gene id: 111015:AXF14_RS02425
uniprot id: A0A109W274
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

111015:AXF14 RS11220
gene id: 111015:AXF14_RS11220
uniprot id: A0A109W331
names: Similarity
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Homohexamer. Assembles into a hexameric ring structure.

111015:AXF14 RS07160
gene id: 111015:AXF14_RS07160
uniprot id: A0A0X8JEK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

111015:AXF14 RS08235
gene id: 111015:AXF14_RS08235
uniprot id: A0A109W7W7
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS02855
gene id: 111015:AXF14_RS02855
uniprot id: A0A109W276
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

111015:AXF14 RS04725
gene id: 111015:AXF14_RS04725
uniprot id: A0A120KLC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

111015:AXF14 RS10410
gene id: 111015:AXF14_RS10410
uniprot id: A0A0X8JGE6
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

111015:AXF14 RS02640
gene id: 111015:AXF14_RS02640
uniprot id: A0A0X8JE01
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

111015:AXF14 RS10200
gene id: 111015:AXF14_RS10200
uniprot id: A0A0X8JFG8
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

111015:AXF14 RS09605
gene id: 111015:AXF14_RS09605
uniprot id: A0A0X8JG61
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

111015:AXF14 RS02720
gene id: 111015:AXF14_RS02720
uniprot id: A0A0X8JDW4
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

111015:AXF14 RS06895
gene id: 111015:AXF14_RS06895
uniprot id: A0A0X8JEH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

111015:AXF14 RS02710
gene id: 111015:AXF14_RS02710
uniprot id: A0A0X8JDS1
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS01775
gene id: 111015:AXF14_RS01775
uniprot id: A0A0X8JDG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

111015:AXF14 RS07970
gene id: 111015:AXF14_RS07970
uniprot id: A0A109W2Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS12790
gene id: 111015:AXF14_RS12790
uniprot id: A0A0X8JGZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

111015:AXF14 RS12360
gene id: 111015:AXF14_RS12360
uniprot id: A0A0X8JGP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

111015:AXF14 RS11855
gene id: 111015:AXF14_RS11855
uniprot id: A0A120KLF9
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS05545
gene id: 111015:AXF14_RS05545
uniprot id: A0A0X8JEH1
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS10250
gene id: 111015:AXF14_RS10250
uniprot id: A0A109W847
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

111015:AXF14 RS11785
gene id: 111015:AXF14_RS11785
uniprot id: A0A109W352
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

111015:AXF14 RS04735
gene id: 111015:AXF14_RS04735
uniprot id: A0A0X8JDR3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of guanine in position 518 of 16S rRNA.

111015:AXF14 RS06035
gene id: 111015:AXF14_RS06035
uniprot id: A0A0X8JEM5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS11155
gene id: 111015:AXF14_RS11155
uniprot id: A0A0X8JFR6
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

111015:AXF14 RS04230
gene id: 111015:AXF14_RS04230
uniprot id: A0A0X8JDL1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

111015:AXF14 RS04745
gene id: 111015:AXF14_RS04745
uniprot id: A0A0X8JDR9
names: Similarity
messages: Belongs to the ParB family.

111015:AXF14 RS09055
gene id: 111015:AXF14_RS09055
uniprot id: A0A0X8JFZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

111015:AXF14 RS09100
gene id: 111015:AXF14_RS09100
uniprot id: A0A109W2V2
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

111015:AXF14 RS11665
gene id: 111015:AXF14_RS11665
uniprot id: A0A0X8JGD0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS08700
gene id: 111015:AXF14_RS08700
uniprot id: A0A120KLA3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

111015:AXF14 RS05785
gene id: 111015:AXF14_RS05785
uniprot id: A0A0X8JE57
names: Similarity
messages: Belongs to the UPF0145 family.

111015:AXF14 RS05735
gene id: 111015:AXF14_RS05735
uniprot id: A0A0X8JEJ4
names: Similarity
messages: Belongs to the OsmC/Ohr family.

111015:AXF14 RS06685
gene id: 111015:AXF14_RS06685
uniprot id: A0A0X8JET9
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

111015:AXF14 RS09070
gene id: 111015:AXF14_RS09070
uniprot id: A0A120KLA7
names: Similarity
messages: Belongs to the YggT family.

111015:AXF14 RS04200
gene id: 111015:AXF14_RS04200
uniprot id: A0A0X8JE79
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

111015:AXF14 RS11450
gene id: 111015:AXF14_RS11450
uniprot id: A0A0X8JFT9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

111015:AXF14 RS09590
gene id: 111015:AXF14_RS09590
uniprot id: A0A0X8JFB1
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

111015:AXF14 RS07885
gene id: 111015:AXF14_RS07885
uniprot id: A0A0X8JET4
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

111015:AXF14 RS09995
gene id: 111015:AXF14_RS09995
uniprot id: A0A0X8JGA2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

111015:AXF14 RS03980
gene id: 111015:AXF14_RS03980
uniprot id: A0A0X8JE78
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

111015:AXF14 RS09320
gene id: 111015:AXF14_RS09320
uniprot id: A0A0X8JF86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

111015:AXF14 RS12135
gene id: 111015:AXF14_RS12135
uniprot id: A0A0X8JG31
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

111015:AXF14 RS10185
gene id: 111015:AXF14_RS10185
uniprot id: A0A0X8JFF9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

111015:AXF14 RS08725
gene id: 111015:AXF14_RS08725
uniprot id: A0A0X8JF26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

111015:AXF14 RS00295
gene id: 111015:AXF14_RS00295
uniprot id: A0A0X8JD18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

111015:AXF14 RS07800
gene id: 111015:AXF14_RS07800
uniprot id: A0A0X8JES9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

111015:AXF14 RS08840
gene id: 111015:AXF14_RS08840
uniprot id: A0A0X8JFH4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

111015:AXF14 RS07765
gene id: 111015:AXF14_RS07765
uniprot id: A0A0X8JF94
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

111015:AXF14 RS10165
gene id: 111015:AXF14_RS10165
uniprot id: A0A0X8JHC5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

111015:AXF14 RS03295
gene id: 111015:AXF14_RS03295
uniprot id: A0A0X8JE13
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

111015:AXF14 RS08665
gene id: 111015:AXF14_RS08665
uniprot id: A0A0X8JF18
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

111015:AXF14 RS09105
gene id: 111015:AXF14_RS09105
uniprot id: A0A0X8JF56
names: Subcellular Location Annotation
messages: Cytoplasm

111015:AXF14 RS00495
gene id: 111015:AXF14_RS00495
uniprot id: A0A0X8JCG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

111015:AXF14 RS00615
gene id: 111015:AXF14_RS00615
uniprot id: A0A0X8JCJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the encapsulin family. Family 1 subfamily.
messages: Encapsulin nanocompartment

111015:AXF14 RS07095
gene id: 111015:AXF14_RS07095
uniprot id: A0A0X8JF44
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

111015:AXF14 RS05540
gene id: 111015:AXF14_RS05540
uniprot id: A0A0X8JGL4
names: Similarity
messages: Belongs to the GSP E family.

111015:AXF14 RS03615
gene id: 111015:AXF14_RS03615
uniprot id: A0A120KKZ9
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

111015:AXF14 RS11315
gene id: 111015:AXF14_RS11315
uniprot id: A0A120KLF6
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

111015:AXF14 RS08675
gene id: 111015:AXF14_RS08675
uniprot id: A0A0X8JFJ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

111015:AXF14 RS11245
gene id: 111015:AXF14_RS11245
uniprot id: A0A0X8JFS7
names: Similarity
messages: Belongs to the YoeB family.

111015:AXF14 RS09455
gene id: 111015:AXF14_RS09455
uniprot id: A0A0X8JF95
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

111015:AXF14 RS09465
gene id: 111015:AXF14_RS09465
uniprot id: A0A0X8JF96
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS08080
gene id: 111015:AXF14_RS08080
uniprot id: A0A0X8JEV0
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS03350
gene id: 111015:AXF14_RS03350
uniprot id: A0A0X8JDE5
names: Subcellular Location Annotation
messages: Cytoplasm

111015:AXF14 RS12275
gene id: 111015:AXF14_RS12275
uniprot id: A0A0X8JGI5
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

111015:AXF14 RS04860
gene id: 111015:AXF14_RS04860
uniprot id: A0A0X8JEA8
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

111015:AXF14 RS04285
gene id: 111015:AXF14_RS04285
uniprot id: A0A109W2D3
names: Similarity
messages: Belongs to the peptidase C1 family.

111015:AXF14 RS05335
gene id: 111015:AXF14_RS05335
uniprot id: A0A0X8JEF7
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

111015:AXF14 RS07080
gene id: 111015:AXF14_RS07080
uniprot id: A0A0X8JEJ6
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

111015:AXF14 RS09730
gene id: 111015:AXF14_RS09730
uniprot id: A0A109W2W8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

111015:AXF14 RS12705
gene id: 111015:AXF14_RS12705
uniprot id: A0A109W385
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

111015:AXF14 RS09660
gene id: 111015:AXF14_RS09660
uniprot id: A0A109W2X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane

111015:AXF14 RS12265
gene id: 111015:AXF14_RS12265
uniprot id: A0A0X8JGP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

111015:AXF14 RS02180
gene id: 111015:AXF14_RS02180
uniprot id: A0A0X8JD01
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS12385
gene id: 111015:AXF14_RS12385
uniprot id: A0A109W378
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

111015:AXF14 RS08340
gene id: 111015:AXF14_RS08340
uniprot id: A0A109W2S7
names: Similarity
messages: Belongs to the LacAB/RpiB family.

111015:AXF14 RS01695
gene id: 111015:AXF14_RS01695
uniprot id: A0A0X8JDI1
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

111015:AXF14 RS12410
gene id: 111015:AXF14_RS12410
uniprot id: A0A120KLH1
names: Similarity
messages: Belongs to the FPG family.

111015:AXF14 RS11250
gene id: 111015:AXF14_RS11250
uniprot id: A0A0X8JFS0
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS11510
gene id: 111015:AXF14_RS11510
uniprot id: A0A109W335
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

111015:AXF14 RS11210
gene id: 111015:AXF14_RS11210
uniprot id: A0A0X8JG85
names: Similarity
messages: Belongs to the prokaryotic ubiquitin-like protein family.

111015:AXF14 RS07715
gene id: 111015:AXF14_RS07715
uniprot id: A0A0X8JH30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

111015:AXF14 RS06270
gene id: 111015:AXF14_RS06270
uniprot id: A0A0X8JEB3
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

111015:AXF14 RS08540
gene id: 111015:AXF14_RS08540
uniprot id: A0A0X8JF03
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

111015:AXF14 RS04770
gene id: 111015:AXF14_RS04770
uniprot id: A0A0X8JE98
names: Similarity
messages: Belongs to the thioredoxin family.

111015:AXF14 RS04865
gene id: 111015:AXF14_RS04865
uniprot id: A0A0X8JDT6
names: Function
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.

111015:AXF14 RS12585
gene id: 111015:AXF14_RS12585
uniprot id: A0A0X8JGN2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS14425
gene id: 111015:AXF14_RS14425
uniprot id: A0A0X8JES2
names: Similarity
messages: Belongs to the DnaX/STICHEL family.

111015:AXF14 RS06965
gene id: 111015:AXF14_RS06965
uniprot id: A0A0X8JH21
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS03495
gene id: 111015:AXF14_RS03495
uniprot id: A0A0X8JDE4
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

111015:AXF14 RS06500
gene id: 111015:AXF14_RS06500
uniprot id: A0A0X8JF51
names: Similarity
messages: Belongs to the Nudix hydrolase family.

111015:AXF14 RS12745
gene id: 111015:AXF14_RS12745
uniprot id: A0A0X8JG72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

111015:AXF14 RS09745
gene id: 111015:AXF14_RS09745
uniprot id: A0A109W2W9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

111015:AXF14 RS03675
gene id: 111015:AXF14_RS03675
uniprot id: A0A0X8JDF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

111015:AXF14 RS11960
gene id: 111015:AXF14_RS11960
uniprot id: A0A0X8JG11
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

111015:AXF14 RS09085
gene id: 111015:AXF14_RS09085
uniprot id: A0A109W7Z6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

111015:AXF14 RS04700
gene id: 111015:AXF14_RS04700
uniprot id: A0A109W2E9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

111015:AXF14 RS07265
gene id: 111015:AXF14_RS07265
uniprot id: A0A0X8JF05
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

111015:AXF14 RS07440
gene id: 111015:AXF14_RS07440
uniprot id: A0A0X8JF21
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

111015:AXF14 RS01375
gene id: 111015:AXF14_RS01375
uniprot id: A0A0X8JDE1
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

111015:AXF14 RS01910
gene id: 111015:AXF14_RS01910
uniprot id: A0A109W7A8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

111015:AXF14 RS06945
gene id: 111015:AXF14_RS06945
uniprot id: A0A0X8JEH2
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

111015:AXF14 RS14730
gene id: 111015:AXF14_RS14730
uniprot id: A0A109W240
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

111015:AXF14 RS07710
gene id: 111015:AXF14_RS07710
uniprot id: A0A0X8JER2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

111015:AXF14 RS12415
gene id: 111015:AXF14_RS12415
uniprot id: A0A120KLP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

111015:AXF14 RS06585
gene id: 111015:AXF14_RS06585
uniprot id: A0A0X8JET0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

111015:AXF14 RS01000
gene id: 111015:AXF14_RS01000
uniprot id: A0A120KL87
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

111015:AXF14 RS10190
gene id: 111015:AXF14_RS10190
uniprot id: A0A0X8JFG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

111015:AXF14 RS12030
gene id: 111015:AXF14_RS12030
uniprot id: A0A109W353
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS05160
gene id: 111015:AXF14_RS05160
uniprot id: A0A109W2F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

111015:AXF14 RS08585
gene id: 111015:AXF14_RS08585
uniprot id: A0A0X8JFI7
names: Function
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

111015:AXF14 RS09015
gene id: 111015:AXF14_RS09015
uniprot id: A0A0X8JF47
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS00325
gene id: 111015:AXF14_RS00325
uniprot id: A0A0X8JCG9
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

111015:AXF14 RS00405
gene id: 111015:AXF14_RS00405
uniprot id: A0A0X8JCG7
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

111015:AXF14 RS11760
gene id: 111015:AXF14_RS11760
uniprot id: A0A0X8JGE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

111015:AXF14 RS11445
gene id: 111015:AXF14_RS11445
uniprot id: A0A0X8JFU7
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

111015:AXF14 RS10970
gene id: 111015:AXF14_RS10970
uniprot id: A0A0X8JFP5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

111015:AXF14 RS04555
gene id: 111015:AXF14_RS04555
uniprot id: A0A0X8JDQ5
names: Similarity
messages: Belongs to the UPF0045 family.

111015:AXF14 RS03875
gene id: 111015:AXF14_RS03875
uniprot id: A0A0X8JE70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS05490
gene id: 111015:AXF14_RS05490
uniprot id: A0A0X8JE34
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS10530
gene id: 111015:AXF14_RS10530
uniprot id: A0A120KMM6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS12080
gene id: 111015:AXF14_RS12080
uniprot id: A0A0X8JGG3
names: Similarity
messages: Belongs to the DtxR/MntR family.

111015:AXF14 RS02790
gene id: 111015:AXF14_RS02790
uniprot id: A0A0X8JD72
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

111015:AXF14 RS07455
gene id: 111015:AXF14_RS07455
uniprot id: A0A0X8JF24
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

111015:AXF14 RS01595
gene id: 111015:AXF14_RS01595
uniprot id: A0A0X8JDQ0
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

111015:AXF14 RS11075
gene id: 111015:AXF14_RS11075
uniprot id: A0A0X8JFR0
names: Subcellular Location Annotation
messages: Cell membrane

111015:AXF14 RS12530
gene id: 111015:AXF14_RS12530
uniprot id: A0A0X8JH46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

111015:AXF14 RS09395
gene id: 111015:AXF14_RS09395
uniprot id: A0A0X8JFN3
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

111015:AXF14 RS11310
gene id: 111015:AXF14_RS11310
uniprot id: A0A109W341
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

111015:AXF14 RS12070
gene id: 111015:AXF14_RS12070
uniprot id: A0A0X8JGN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

111015:AXF14 RS07275
gene id: 111015:AXF14_RS07275
uniprot id: A0A0X8JEL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

111015:AXF14 RS07810
gene id: 111015:AXF14_RS07810
uniprot id: A0A0X8JES8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS04365
gene id: 111015:AXF14_RS04365
uniprot id: A0A0X8JEA7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

111015:AXF14 RS01245
gene id: 111015:AXF14_RS01245
uniprot id: A0A0X8JDI8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

111015:AXF14 RS11745
gene id: 111015:AXF14_RS11745
uniprot id: A0A0X8JG00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Homodimer.

111015:AXF14 RS04775
gene id: 111015:AXF14_RS04775
uniprot id: A0A0X8JDS3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

111015:AXF14 RS06645
gene id: 111015:AXF14_RS06645
uniprot id: A0A109W2L6
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS11700
gene id: 111015:AXF14_RS11700
uniprot id: A0A109W345
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

111015:AXF14 RS00835
gene id: 111015:AXF14_RS00835
uniprot id: A0A0X8JDF3
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

111015:AXF14 RS10445
gene id: 111015:AXF14_RS10445
uniprot id: A0A120KLD4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

111015:AXF14 RS08325
gene id: 111015:AXF14_RS08325
uniprot id: A0A109W2S2
names: Similarity
messages: Belongs to the peptidase M1 family.

111015:AXF14 RS09410
gene id: 111015:AXF14_RS09410
uniprot id: A0A0X8JFN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS05730
gene id: 111015:AXF14_RS05730
uniprot id: A0A0X8JEW2
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS11570
gene id: 111015:AXF14_RS11570
uniprot id: A0A0X8JGA5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'P' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Non-allosteric.

111015:AXF14 RS08440
gene id: 111015:AXF14_RS08440
uniprot id: A0A0X8JEZ0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

111015:AXF14 RS04710
gene id: 111015:AXF14_RS04710
uniprot id: A0A120KL25
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

111015:AXF14 RS07295
gene id: 111015:AXF14_RS07295
uniprot id: A0A109W2P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

111015:AXF14 RS02235
gene id: 111015:AXF14_RS02235
uniprot id: A0A120KMC7
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

111015:AXF14 RS05480
gene id: 111015:AXF14_RS05480
uniprot id: A0A109W2H4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

111015:AXF14 RS11135
gene id: 111015:AXF14_RS11135
uniprot id: A0A0X8JGV3
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

111015:AXF14 RS06505
gene id: 111015:AXF14_RS06505
uniprot id: A0A0X8JES7
names: Similarity
messages: Belongs to the PstS family.

111015:AXF14 RS09580
gene id: 111015:AXF14_RS09580
uniprot id: A0A0X8JFB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

111015:AXF14 RS00170
gene id: 111015:AXF14_RS00170
uniprot id: A0A0X8JCE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS06955
gene id: 111015:AXF14_RS06955
uniprot id: A0A0X8JF09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

111015:AXF14 RS12395
gene id: 111015:AXF14_RS12395
uniprot id: A0A0X8JGJ9
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS01885
gene id: 111015:AXF14_RS01885
uniprot id: A0A0X8JDU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

111015:AXF14 RS11540
gene id: 111015:AXF14_RS11540
uniprot id: A0A0X8JFU9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

111015:AXF14 RS11400
gene id: 111015:AXF14_RS11400
uniprot id: A0A120KLF0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

111015:AXF14 RS08740
gene id: 111015:AXF14_RS08740
uniprot id: A0A0X8JF25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

111015:AXF14 RS08230
gene id: 111015:AXF14_RS08230
uniprot id: A0A0X8JFE6
names: Similarity
messages: Belongs to the GSP E family.

111015:AXF14 RS09040
gene id: 111015:AXF14_RS09040
uniprot id: A0A0X8JFJ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS06770
gene id: 111015:AXF14_RS06770
uniprot id: A0A0X8JEF4
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

111015:AXF14 RS00230
gene id: 111015:AXF14_RS00230
uniprot id: A0A109W1Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

111015:AXF14 RS07260
gene id: 111015:AXF14_RS07260
uniprot id: A0A109W3C1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

111015:AXF14 RS01065
gene id: 111015:AXF14_RS01065
uniprot id: A0A120KKV3
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

111015:AXF14 RS12540
gene id: 111015:AXF14_RS12540
uniprot id: A0A0X8JG58
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS10195
gene id: 111015:AXF14_RS10195
uniprot id: A0A0X8JFG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

111015:AXF14 RS06235
gene id: 111015:AXF14_RS06235
uniprot id: A0A0X8JEU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

111015:AXF14 RS04290
gene id: 111015:AXF14_RS04290
uniprot id: A0A109W2D4
names: Function
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

111015:AXF14 RS02140
gene id: 111015:AXF14_RS02140
uniprot id: A0A109W262
names: Similarity
messages: Belongs to the arginine deiminase family.

111015:AXF14 RS00370
gene id: 111015:AXF14_RS00370
uniprot id: A0A0X8JCG2
names: Similarity
messages: Belongs to the AAE transporter (TC 2.A.81) family.

111015:AXF14 RS05345
gene id: 111015:AXF14_RS05345
uniprot id: A0A120KL26
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS02475
gene id: 111015:AXF14_RS02475
uniprot id: A0A0X8JDU5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

111015:AXF14 RS07770
gene id: 111015:AXF14_RS07770
uniprot id: A0A109W2Q3
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS10270
gene id: 111015:AXF14_RS10270
uniprot id: A0A0X8JFG6
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS07105
gene id: 111015:AXF14_RS07105
uniprot id: A0A0X8JFB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

111015:AXF14 RS07645
gene id: 111015:AXF14_RS07645
uniprot id: A0A0X8JEQ4
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS06005
gene id: 111015:AXF14_RS06005
uniprot id: A0A0X8JE80
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS09295
gene id: 111015:AXF14_RS09295
uniprot id: A0A0X8JF82
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

111015:AXF14 RS07620
gene id: 111015:AXF14_RS07620
uniprot id: A0A0X8JEQ8
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS04560
gene id: 111015:AXF14_RS04560
uniprot id: A0A109W2E2
names: Similarity
messages: Belongs to the AAE transporter (TC 2.A.81) family.

111015:AXF14 RS00415
gene id: 111015:AXF14_RS00415
uniprot id: A0A0X8JDB3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

111015:AXF14 RS03355
gene id: 111015:AXF14_RS03355
uniprot id: A0A0X8JDC7
names: Subcellular Location Annotation
messages: Cytoplasm

111015:AXF14 RS03050
gene id: 111015:AXF14_RS03050
uniprot id: A0A0X8JD91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Belongs to the precorrin methyltransferase family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

111015:AXF14 RS02825
gene id: 111015:AXF14_RS02825
uniprot id: A0A0X8JE15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

111015:AXF14 RS06135
gene id: 111015:AXF14_RS06135
uniprot id: A0A0X8JET6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

111015:AXF14 RS12570
gene id: 111015:AXF14_RS12570
uniprot id: A0A0X8JGK2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

111015:AXF14 RS02035
gene id: 111015:AXF14_RS02035
uniprot id: A0A120KLI6
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

111015:AXF14 RS07340
gene id: 111015:AXF14_RS07340
uniprot id: A0A0X8JF11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

111015:AXF14 RS01720
gene id: 111015:AXF14_RS01720
uniprot id: A0A109W238
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

111015:AXF14 RS02955
gene id: 111015:AXF14_RS02955
uniprot id: A0A120KLA0
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

111015:AXF14 RS10980
gene id: 111015:AXF14_RS10980
uniprot id: A0A0X8JGB5
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

111015:AXF14 RS02330
gene id: 111015:AXF14_RS02330
uniprot id: A0A109W258
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS00135
gene id: 111015:AXF14_RS00135
uniprot id: A0A109W762
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS07895
gene id: 111015:AXF14_RS07895
uniprot id: A0A0X8JF71
names: Function
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

111015:AXF14 RS09245
gene id: 111015:AXF14_RS09245
uniprot id: A0A109W2W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

111015:AXF14 RS02350
gene id: 111015:AXF14_RS02350
uniprot id: A0A0X8JHA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

111015:AXF14 RS08780
gene id: 111015:AXF14_RS08780
uniprot id: A0A120KLA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

111015:AXF14 RS12840
gene id: 111015:AXF14_RS12840
uniprot id: A0A109W390
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS10245
gene id: 111015:AXF14_RS10245
uniprot id: A0A0X8JFY4
names: Cofactor
messages: Binds 4 [4Fe-4S] clusters per subunit.

111015:AXF14 RS01880
gene id: 111015:AXF14_RS01880
uniprot id: A0A0X8JDQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

111015:AXF14 RS07310
gene id: 111015:AXF14_RS07310
uniprot id: A0A120KLG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

111015:AXF14 RS09615
gene id: 111015:AXF14_RS09615
uniprot id: A0A0X8JFB6
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

111015:AXF14 RS07745
gene id: 111015:AXF14_RS07745
uniprot id: A0A0X8JF59
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

111015:AXF14 RS11720
gene id: 111015:AXF14_RS11720
uniprot id: A0A0X8JFX7
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

111015:AXF14 RS10985
gene id: 111015:AXF14_RS10985
uniprot id: A0A0X8JGJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

111015:AXF14 RS00480
gene id: 111015:AXF14_RS00480
uniprot id: A0A0X8JGC7
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS07695
gene id: 111015:AXF14_RS07695
uniprot id: A0A109W2P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

111015:AXF14 RS09390
gene id: 111015:AXF14_RS09390
uniprot id: A0A0X8JF90
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

111015:AXF14 RS08940
gene id: 111015:AXF14_RS08940
uniprot id: A0A0X8JF43
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

111015:AXF14 RS08335
gene id: 111015:AXF14_RS08335
uniprot id: A0A109W2S3
names: Similarity
messages: Belongs to the peptidase M13 family.

111015:AXF14 RS12860
gene id: 111015:AXF14_RS12860
uniprot id: A0A0X8JG86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS12675
gene id: 111015:AXF14_RS12675
uniprot id: A0A0X8JGL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

111015:AXF14 RS12765
gene id: 111015:AXF14_RS12765
uniprot id: A0A0X8JG92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

111015:AXF14 RS04940
gene id: 111015:AXF14_RS04940
uniprot id: A0A0X8JEH8
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

111015:AXF14 RS00830
gene id: 111015:AXF14_RS00830
uniprot id: A0A0X8JGX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

111015:AXF14 RS10175
gene id: 111015:AXF14_RS10175
uniprot id: A0A120KLC8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

111015:AXF14 RS10495
gene id: 111015:AXF14_RS10495
uniprot id: A0A0X8JG65
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS00360
gene id: 111015:AXF14_RS00360
uniprot id: A0A120KL84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

111015:AXF14 RS08530
gene id: 111015:AXF14_RS08530
uniprot id: A0A0X8JF00
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

111015:AXF14 RS02345
gene id: 111015:AXF14_RS02345
uniprot id: A0A0X8JD15
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS10460
gene id: 111015:AXF14_RS10460
uniprot id: A0A0X8JFI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

111015:AXF14 RS05450
gene id: 111015:AXF14_RS05450
uniprot id: A0A109W2H3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

111015:AXF14 RS08360
gene id: 111015:AXF14_RS08360
uniprot id: A0A0X8JEY5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

111015:AXF14 RS05155
gene id: 111015:AXF14_RS05155
uniprot id: A0A0X8JEI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

111015:AXF14 RS12235
gene id: 111015:AXF14_RS12235
uniprot id: A0A0X8JG41
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS01080
gene id: 111015:AXF14_RS01080
uniprot id: A0A120KMB0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS08605
gene id: 111015:AXF14_RS08605
uniprot id: A0A109W2T3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for chromosome condensation and partitioning.

111015:AXF14 RS12355
gene id: 111015:AXF14_RS12355
uniprot id: A0A0X8JGJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

111015:AXF14 RS09165
gene id: 111015:AXF14_RS09165
uniprot id: A0A0X8JFN5
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

111015:AXF14 RS04035
gene id: 111015:AXF14_RS04035
uniprot id: A0A109W2B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

111015:AXF14 RS07865
gene id: 111015:AXF14_RS07865
uniprot id: A0A120KLH4
names: Similarity
messages: Belongs to the ABC transporter superfamily.

111015:AXF14 RS11340
gene id: 111015:AXF14_RS11340
uniprot id: A0A0X8JFS9
names: Similarity
messages: Belongs to the TPP enzyme family.

111015:AXF14 RS06885
gene id: 111015:AXF14_RS06885
uniprot id: A0A109W2L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

111015:AXF14 RS05425
gene id: 111015:AXF14_RS05425
uniprot id: A0A0X8JEM1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ChdC family. Type 2 subfamily.
messages: Fe-coproporphyrin III acts as both substrate and redox cofactor.
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate.

111015:AXF14 RS02580
gene id: 111015:AXF14_RS02580
uniprot id: A0A0X8JDS0
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

111015:AXF14 RS12455
gene id: 111015:AXF14_RS12455
uniprot id: A0A0X8JGK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L-fucose isomerase family.
messages: Converts the aldose L-fucose into the corresponding ketose L-fuculose.
messages: Cytoplasm

111015:AXF14 RS03705
gene id: 111015:AXF14_RS03705
uniprot id: A0A0X8JDG6
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

111015:AXF14 RS01945
gene id: 111015:AXF14_RS01945
uniprot id: A0A0X8JCY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

111015:AXF14 RS02315
gene id: 111015:AXF14_RS02315
uniprot id: A0A109W254
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

111015:AXF14 RS09675
gene id: 111015:AXF14_RS09675
uniprot id: A0A0X8JFB9
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

111015:AXF14 RS03505
gene id: 111015:AXF14_RS03505
uniprot id: A0A109W297
names: Similarity
messages: Belongs to the ABC transporter superfamily.

111015:AXF14 RS05175
gene id: 111015:AXF14_RS05175
uniprot id: A0A0X8JGU4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

111015:AXF14 RS07235
gene id: 111015:AXF14_RS07235
uniprot id: A0A0X8JEL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

111015:AXF14 RS07875
gene id: 111015:AXF14_RS07875
uniprot id: A0A0X8JET7
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

111015:AXF14 RS08630
gene id: 111015:AXF14_RS08630
uniprot id: A0A0X8JF13
names: Similarity
messages: Belongs to the P(II) protein family.

111015:AXF14 RS10930
gene id: 111015:AXF14_RS10930
uniprot id: A0A109W319
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

111015:AXF14 RS08175
gene id: 111015:AXF14_RS08175
uniprot id: A0A0X8JEW5
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

111015:AXF14 RS12545
gene id: 111015:AXF14_RS12545
uniprot id: A0A0X8JG69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

111015:AXF14 RS08820
gene id: 111015:AXF14_RS08820
uniprot id: A0A0X8JF35
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS08535
gene id: 111015:AXF14_RS08535
uniprot id: A0A0X8JF07
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

111015:AXF14 RS06575
gene id: 111015:AXF14_RS06575
uniprot id: A0A0X8JEE3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

111015:AXF14 RS05570
gene id: 111015:AXF14_RS05570
uniprot id: A0A109W2H7
names: Function
names: Similarity
names: Subunit
messages: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
messages: Belongs to the AhpD family.
messages: Homotrimer.

111015:AXF14 RS04910
gene id: 111015:AXF14_RS04910
uniprot id: A0A0X8JDU6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

111015:AXF14 RS05045
gene id: 111015:AXF14_RS05045
uniprot id: A0A0X8JEC8
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

111015:AXF14 RS04445
gene id: 111015:AXF14_RS04445
uniprot id: A0A0X8JDP6
names: Similarity
messages: Belongs to the XFP family.

111015:AXF14 RS09880
gene id: 111015:AXF14_RS09880
uniprot id: A0A0X8JFD2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

111015:AXF14 RS02780
gene id: 111015:AXF14_RS02780
uniprot id: A0A0X8JD85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

111015:AXF14 RS00890
gene id: 111015:AXF14_RS00890
uniprot id: A0A0X8JCN0
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

111015:AXF14 RS12340
gene id: 111015:AXF14_RS12340
uniprot id: A0A0X8JG52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

111015:AXF14 RS03345
gene id: 111015:AXF14_RS03345
uniprot id: A0A109W295
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS07240
gene id: 111015:AXF14_RS07240
uniprot id: A0A0X8JEL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

111015:AXF14 RS05810
gene id: 111015:AXF14_RS05810
uniprot id: A0A0X8JE59
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS01315
gene id: 111015:AXF14_RS01315
uniprot id: A0A120KL88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS04695
gene id: 111015:AXF14_RS04695
uniprot id: A0A0X8JED7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

111015:AXF14 RS11505
gene id: 111015:AXF14_RS11505
uniprot id: A0A109W340
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

111015:AXF14 RS08975
gene id: 111015:AXF14_RS08975
uniprot id: A0A0X8JF48
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS00565
gene id: 111015:AXF14_RS00565
uniprot id: A0A0X8JD64
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.

111015:AXF14 RS08915
gene id: 111015:AXF14_RS08915
uniprot id: A0A109W2U8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

111015:AXF14 RS03030
gene id: 111015:AXF14_RS03030
uniprot id: A0A120KMD9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Monomer.

111015:AXF14 RS07635
gene id: 111015:AXF14_RS07635
uniprot id: A0A0X8JFI3
names: Similarity
messages: Belongs to the glutathione peroxidase family.

111015:AXF14 RS05895
gene id: 111015:AXF14_RS05895
uniprot id: A0A120KLE2
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS01755
gene id: 111015:AXF14_RS01755
uniprot id: A0A0X8JCW1
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.

111015:AXF14 RS08005
gene id: 111015:AXF14_RS08005
uniprot id: A0A0X8JGQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
messages: Cytoplasm

111015:AXF14 RS08465
gene id: 111015:AXF14_RS08465
uniprot id: A0A0X8JFK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

111015:AXF14 RS07300
gene id: 111015:AXF14_RS07300
uniprot id: A0A120KL65
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

111015:AXF14 RS00055
gene id: 111015:AXF14_RS00055
uniprot id: A0A109W1Y5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

111015:AXF14 RS02280
gene id: 111015:AXF14_RS02280
uniprot id: A0A0X8JDT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

111015:AXF14 RS09030
gene id: 111015:AXF14_RS09030
uniprot id: A0A0X8JF53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

111015:AXF14 RS03970
gene id: 111015:AXF14_RS03970
uniprot id: A0A0X8JE16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

111015:AXF14 RS07210
gene id: 111015:AXF14_RS07210
uniprot id: A0A109W2M9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

111015:AXF14 RS03725
gene id: 111015:AXF14_RS03725
uniprot id: A0A109W2B4
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

111015:AXF14 RS08160
gene id: 111015:AXF14_RS08160
uniprot id: A0A120KLH9
names: Similarity
messages: Belongs to the DEAD box helicase family.

111015:AXF14 RS11455
gene id: 111015:AXF14_RS11455
uniprot id: A0A0X8JFU5
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS09175
gene id: 111015:AXF14_RS09175
uniprot id: A0A109W2V1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

111015:AXF14 RS09990
gene id: 111015:AXF14_RS09990
uniprot id: A0A0X8JG17
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

111015:AXF14 RS04705
gene id: 111015:AXF14_RS04705
uniprot id: A0A120KL24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

111015:AXF14 RS06050
gene id: 111015:AXF14_RS06050
uniprot id: A0A0X8JGL8
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

111015:AXF14 RS07760
gene id: 111015:AXF14_RS07760
uniprot id: A0A109W2P9
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.

111015:AXF14 RS10160
gene id: 111015:AXF14_RS10160
uniprot id: A0A109W2Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

111015:AXF14 RS11940
gene id: 111015:AXF14_RS11940
uniprot id: A0A109W356
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

111015:AXF14 RS12065
gene id: 111015:AXF14_RS12065
uniprot id: A0A0X8JGG5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS02195
gene id: 111015:AXF14_RS02195
uniprot id: A0A0X8JDS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

111015:AXF14 RS05890
gene id: 111015:AXF14_RS05890
uniprot id: A0A120KLJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

111015:AXF14 RS05260
gene id: 111015:AXF14_RS05260
uniprot id: A0A109W2G7
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS05120
gene id: 111015:AXF14_RS05120
uniprot id: A0A0X8JED6
names: Similarity
messages: Belongs to the peptidase M20A family.

111015:AXF14 RS00930
gene id: 111015:AXF14_RS00930
uniprot id: A0A0X8JDG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

111015:AXF14 RS11430
gene id: 111015:AXF14_RS11430
uniprot id: A0A109W336
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS07145
gene id: 111015:AXF14_RS07145
uniprot id: A0A109W2M8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

111015:AXF14 RS07465
gene id: 111015:AXF14_RS07465
uniprot id: A0A109W2P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

111015:AXF14 RS07670
gene id: 111015:AXF14_RS07670
uniprot id: A0A0X8JF83
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS01780
gene id: 111015:AXF14_RS01780
uniprot id: A0A0X8JDP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS01920
gene id: 111015:AXF14_RS01920
uniprot id: A0A109W248
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

111015:AXF14 RS03390
gene id: 111015:AXF14_RS03390
uniprot id: A0A0X8JE73
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

111015:AXF14 RS01930
gene id: 111015:AXF14_RS01930
uniprot id: A0A0X8JCY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

111015:AXF14 RS01765
gene id: 111015:AXF14_RS01765
uniprot id: A0A0X8JGZ1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS02970
gene id: 111015:AXF14_RS02970
uniprot id: A0A0X8JD90
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

111015:AXF14 RS08850
gene id: 111015:AXF14_RS08850
uniprot id: A0A0X8JFY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

111015:AXF14 RS01650
gene id: 111015:AXF14_RS01650
uniprot id: A0A0X8JCV0
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

111015:AXF14 RS04095
gene id: 111015:AXF14_RS04095
uniprot id: A0A0X8JEE6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

111015:AXF14 RS06070
gene id: 111015:AXF14_RS06070
uniprot id: A0A109W2J2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

111015:AXF14 RS04835
gene id: 111015:AXF14_RS04835
uniprot id: A0A0X8JDT7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

111015:AXF14 RS05135
gene id: 111015:AXF14_RS05135
uniprot id: A0A0X8JED8
names: Caution
names: Similarity
messages: Belongs to the peptidase S8 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS06890
gene id: 111015:AXF14_RS06890
uniprot id: A0A0X8JEG3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS04405
gene id: 111015:AXF14_RS04405
uniprot id: A0A0X8JDP3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.

111015:AXF14 RS11995
gene id: 111015:AXF14_RS11995
uniprot id: A0A0X8JG27
names: Similarity
messages: Belongs to the ABC transporter superfamily.

111015:AXF14 RS01850
gene id: 111015:AXF14_RS01850
uniprot id: A0A0X8JCX8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

111015:AXF14 RS11165
gene id: 111015:AXF14_RS11165
uniprot id: A0A0X8JFR4
names: Similarity
messages: Belongs to the glutamate synthase family.

111015:AXF14 RS00355
gene id: 111015:AXF14_RS00355
uniprot id: A0A0X8JGB9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS06455
gene id: 111015:AXF14_RS06455
uniprot id: A0A0X8JEC0
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

111015:AXF14 RS08275
gene id: 111015:AXF14_RS08275
uniprot id: A0A0X8JEX5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

111015:AXF14 RS01215
gene id: 111015:AXF14_RS01215
uniprot id: A0A0X8JCQ9
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS08810
gene id: 111015:AXF14_RS08810
uniprot id: A0A109W2U3
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

111015:AXF14 RS07175
gene id: 111015:AXF14_RS07175
uniprot id: A0A0X8JF57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

111015:AXF14 RS06470
gene id: 111015:AXF14_RS06470
uniprot id: A0A0X8JED5
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

111015:AXF14 RS03090
gene id: 111015:AXF14_RS03090
uniprot id: A0A0X8JDU3
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

111015:AXF14 RS07110
gene id: 111015:AXF14_RS07110
uniprot id: A0A0X8JEY4
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

111015:AXF14 RS06765
gene id: 111015:AXF14_RS06765
uniprot id: A0A120KLF4
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

111015:AXF14 RS10025
gene id: 111015:AXF14_RS10025
uniprot id: A0A120KLT0
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS09075
gene id: 111015:AXF14_RS09075
uniprot id: A0A0X8JFM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

111015:AXF14 RS11080
gene id: 111015:AXF14_RS11080
uniprot id: A0A0X8JG53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

111015:AXF14 RS09520
gene id: 111015:AXF14_RS09520
uniprot id: A0A0X8JG50
names: Similarity
messages: Belongs to the TlyA family.

111015:AXF14 RS06740
gene id: 111015:AXF14_RS06740
uniprot id: A0A109W2M1
names: Similarity
messages: Belongs to the peptidase S13 family.

111015:AXF14 RS10720
gene id: 111015:AXF14_RS10720
uniprot id: A0A0X8JG38
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Bind 1 Zn(2+) per subunit.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.

111015:AXF14 RS12775
gene id: 111015:AXF14_RS12775
uniprot id: A0A0X8JGU0
names: Similarity
messages: Belongs to the CapA family.

111015:AXF14 RS08670
gene id: 111015:AXF14_RS08670
uniprot id: A0A109W2U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A probable RNA-binding protein.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm

111015:AXF14 RS10090
gene id: 111015:AXF14_RS10090
uniprot id: A0A0X8JFG0
names: Similarity
messages: Belongs to the FemABX family.

111015:AXF14 RS07150
gene id: 111015:AXF14_RS07150
uniprot id: A0A0X8JEJ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

111015:AXF14 RS08375
gene id: 111015:AXF14_RS08375
uniprot id: A0A0X8JFJ9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

111015:AXF14 RS11590
gene id: 111015:AXF14_RS11590
uniprot id: A0A109W349
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

111015:AXF14 RS04840
gene id: 111015:AXF14_RS04840
uniprot id: A0A0X8JEA4
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

111015:AXF14 RS01890
gene id: 111015:AXF14_RS01890
uniprot id: A0A0X8JDH2
names: Subcellular Location Annotation
messages: Membrane

111015:AXF14 RS10450
gene id: 111015:AXF14_RS10450
uniprot id: A0A120KLL5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

111015:AXF14 RS08770
gene id: 111015:AXF14_RS08770
uniprot id: A0A0X8JF28
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

111015:AXF14 RS07255
gene id: 111015:AXF14_RS07255
uniprot id: A0A0X8JFD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

111015:AXF14 RS10100
gene id: 111015:AXF14_RS10100
uniprot id: A0A0X8JFF7
names: Similarity
messages: Belongs to the FemABX family.