1089553:TPH RS03520
gene id: 1089553:TPH_RS03520
uniprot id: K4LDN1
names: Subcellular Location Annotation
messages: Bacterial microcompartment

1089553:TPH RS09815
gene id: 1089553:TPH_RS09815
uniprot id: K4LVY0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

1089553:TPH RS00980
gene id: 1089553:TPH_RS00980
uniprot id: K4LEC8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1089553:TPH RS08845
gene id: 1089553:TPH_RS08845
uniprot id: K4LVD4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

1089553:TPH RS13470
gene id: 1089553:TPH_RS13470
uniprot id: K4LLD0
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

1089553:TPH RS07030
gene id: 1089553:TPH_RS07030
uniprot id: K4LI24
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

1089553:TPH RS13530
gene id: 1089553:TPH_RS13530
uniprot id: K4LIS4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1089553:TPH RS11050
gene id: 1089553:TPH_RS11050
uniprot id: K4LKD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

1089553:TPH RS05650
gene id: 1089553:TPH_RS05650
uniprot id: K4LHC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1089553:TPH RS09870
gene id: 1089553:TPH_RS09870
uniprot id: K4LJP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1089553:TPH RS08530
gene id: 1089553:TPH_RS08530
uniprot id: K4LFY2
names: Similarity
messages: Belongs to the CdaR family.

1089553:TPH RS05625
gene id: 1089553:TPH_RS05625
uniprot id: K4LHC5
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS05020
gene id: 1089553:TPH_RS05020
uniprot id: K4LEE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1089553:TPH RS04610
gene id: 1089553:TPH_RS04610
uniprot id: K4LGQ3
names: Similarity
messages: Belongs to the HypD family.

1089553:TPH RS05845
gene id: 1089553:TPH_RS05845
uniprot id: K4LH48
names: Similarity
messages: Belongs to the peptidase C40 family.

1089553:TPH RS05585
gene id: 1089553:TPH_RS05585
uniprot id: K4LH11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1089553:TPH RS12920
gene id: 1089553:TPH_RS12920
uniprot id: K4LII8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1089553:TPH RS04740
gene id: 1089553:TPH_RS04740
uniprot id: K4LDR9
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS12815
gene id: 1089553:TPH_RS12815
uniprot id: K4LIN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1089553:TPH RS12835
gene id: 1089553:TPH_RS12835
uniprot id: K4LL14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1089553:TPH RS05080
gene id: 1089553:TPH_RS05080
uniprot id: K4LT53
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1089553:TPH RS08010
gene id: 1089553:TPH_RS08010
uniprot id: K4LIP4
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

1089553:TPH RS00025
gene id: 1089553:TPH_RS00025
uniprot id: K4LC04
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1089553:TPH RS11140
gene id: 1089553:TPH_RS11140
uniprot id: K4LHS4
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

1089553:TPH RS07705
gene id: 1089553:TPH_RS07705
uniprot id: K4LIF6
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS06250
gene id: 1089553:TPH_RS06250
uniprot id: K4LHN3
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS11005
gene id: 1089553:TPH_RS11005
uniprot id: K4LKC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

1089553:TPH RS13355
gene id: 1089553:TPH_RS13355
uniprot id: K4LLN0
names: Similarity
messages: Belongs to the peptidase A31 family.

1089553:TPH RS02650
gene id: 1089553:TPH_RS02650
uniprot id: K4LF98
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1089553:TPH RS00970
gene id: 1089553:TPH_RS00970
uniprot id: K4LEN1
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

1089553:TPH RS05360
gene id: 1089553:TPH_RS05360
uniprot id: K4LEP9
names: Similarity
messages: Belongs to the DprA/Smf family.

1089553:TPH RS13595
gene id: 1089553:TPH_RS13595
uniprot id: K4LIT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1089553:TPH RS04450
gene id: 1089553:TPH_RS04450
uniprot id: K4LGA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1089553:TPH RS13715
gene id: 1089553:TPH_RS13715
uniprot id: K4LLU2
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS10060
gene id: 1089553:TPH_RS10060
uniprot id: K4LJJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methylaspartate mutase GlmS subunit family.
messages: Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
messages: Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.

1089553:TPH RS00615
gene id: 1089553:TPH_RS00615
uniprot id: K4LE68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1089553:TPH RS04270
gene id: 1089553:TPH_RS04270
uniprot id: K4LDK0
names: Similarity
messages: Belongs to the GARS family.

1089553:TPH RS12245
gene id: 1089553:TPH_RS12245
uniprot id: K4LI11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

1089553:TPH RS09840
gene id: 1089553:TPH_RS09840
uniprot id: K4LVY6
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1089553:TPH RS04170
gene id: 1089553:TPH_RS04170
uniprot id: K4LDI1
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1089553:TPH RS09875
gene id: 1089553:TPH_RS09875
uniprot id: K4LGP5
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1089553:TPH RS13270
gene id: 1089553:TPH_RS13270
uniprot id: K4LLM0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1089553:TPH RS10170
gene id: 1089553:TPH_RS10170
uniprot id: K4LH73
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1089553:TPH RS02630
gene id: 1089553:TPH_RS02630
uniprot id: K4LD88
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS08900
gene id: 1089553:TPH_RS08900
uniprot id: K4LJ51
names: Similarity
messages: Belongs to the HypE family.

1089553:TPH RS07835
gene id: 1089553:TPH_RS07835
uniprot id: K4LIL2
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

1089553:TPH RS10765
gene id: 1089553:TPH_RS10765
uniprot id: K4LWJ2
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

1089553:TPH RS06355
gene id: 1089553:TPH_RS06355
uniprot id: K4LEL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

1089553:TPH RS10320
gene id: 1089553:TPH_RS10320
uniprot id: K4LK21
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

1089553:TPH RS02690
gene id: 1089553:TPH_RS02690
uniprot id: K4LRR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

1089553:TPH RS03685
gene id: 1089553:TPH_RS03685
uniprot id: K4LDA8
names: Similarity
messages: Belongs to the peptidase A24 family.

1089553:TPH RS01175
gene id: 1089553:TPH_RS01175
uniprot id: K4LER9
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS02655
gene id: 1089553:TPH_RS02655
uniprot id: K4LD93
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1089553:TPH RS08300
gene id: 1089553:TPH_RS08300
uniprot id: K4LG99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS02365
gene id: 1089553:TPH_RS02365
uniprot id: K4LF34
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1089553:TPH RS02575
gene id: 1089553:TPH_RS02575
uniprot id: K4LCS9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

1089553:TPH RS02955
gene id: 1089553:TPH_RS02955
uniprot id: K4LD11
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1089553:TPH RS02615
gene id: 1089553:TPH_RS02615
uniprot id: K4LRN5
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

1089553:TPH RS04100
gene id: 1089553:TPH_RS04100
uniprot id: K4LG32
names: Similarity
messages: Belongs to the transglycosylase Slt family.

1089553:TPH RS12675
gene id: 1089553:TPH_RS12675
uniprot id: K4LL66
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1089553:TPH RS02035
gene id: 1089553:TPH_RS02035
uniprot id: K4LEX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1089553:TPH RS03880
gene id: 1089553:TPH_RS03880
uniprot id: K4LFZ1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1089553:TPH RS04460
gene id: 1089553:TPH_RS04460
uniprot id: K4LSS6
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1089553:TPH RS06940
gene id: 1089553:TPH_RS06940
uniprot id: K4LHQ8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1089553:TPH RS14290
gene id: 1089553:TPH_RS14290
uniprot id: K4LYP1
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS05685
gene id: 1089553:TPH_RS05685
uniprot id: K4LH24
names: Similarity
messages: Belongs to the ribF family.

1089553:TPH RS01005
gene id: 1089553:TPH_RS01005
uniprot id: K4LBZ9
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1089553:TPH RS09115
gene id: 1089553:TPH_RS09115
uniprot id: K4LVI8
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS12760
gene id: 1089553:TPH_RS12760
uniprot id: K4LL01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1089553:TPH RS08315
gene id: 1089553:TPH_RS08315
uniprot id: K4LFU2
names: Similarity
messages: Belongs to the GSP E family.

1089553:TPH RS12785
gene id: 1089553:TPH_RS12785
uniprot id: K4LL05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1089553:TPH RS07465
gene id: 1089553:TPH_RS07465
uniprot id: K4LF94
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1089553:TPH RS09800
gene id: 1089553:TPH_RS09800
uniprot id: K4LGM8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1089553:TPH RS03230
gene id: 1089553:TPH_RS03230
uniprot id: K4LD47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

1089553:TPH RS02870
gene id: 1089553:TPH_RS02870
uniprot id: K4LFS2
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

1089553:TPH RS11440
gene id: 1089553:TPH_RS11440
uniprot id: K4LK88
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS01620
gene id: 1089553:TPH_RS01620
uniprot id: K4LEP2
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1089553:TPH RS02695
gene id: 1089553:TPH_RS02695
uniprot id: K4LFM4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

1089553:TPH RS09295
gene id: 1089553:TPH_RS09295
uniprot id: K4LJ26
names: Similarity
messages: Belongs to the peptidase C40 family.

1089553:TPH RS11740
gene id: 1089553:TPH_RS11740
uniprot id: K4LI38
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

1089553:TPH RS08290
gene id: 1089553:TPH_RS08290
uniprot id: K4LFT8
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS10480
gene id: 1089553:TPH_RS10480
uniprot id: K4LWE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1089553:TPH RS13235
gene id: 1089553:TPH_RS13235
uniprot id: K4LLL6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

1089553:TPH RS07160
gene id: 1089553:TPH_RS07160
uniprot id: K4LF27
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS13265
gene id: 1089553:TPH_RS13265
uniprot id: K4LY27
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1089553:TPH RS01675
gene id: 1089553:TPH_RS01675
uniprot id: K4LCT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

1089553:TPH RS13140
gene id: 1089553:TPH_RS13140
uniprot id: K4LIL3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1089553:TPH RS07660
gene id: 1089553:TPH_RS07660
uniprot id: K4LIE7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1089553:TPH RS05370
gene id: 1089553:TPH_RS05370
uniprot id: K4LH84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

1089553:TPH RS04330
gene id: 1089553:TPH_RS04330
uniprot id: K4LE01
names: Similarity
messages: Belongs to the asparagine synthetase family.

1089553:TPH RS04905
gene id: 1089553:TPH_RS04905
uniprot id: K4LGW3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS10045
gene id: 1089553:TPH_RS10045
uniprot id: K4LW34
names: Similarity
names: Subunit
messages: Belongs to the methylaspartate ammonia-lyase family.
messages: Homodimer.

1089553:TPH RS12485
gene id: 1089553:TPH_RS12485
uniprot id: K4LIG7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1089553:TPH RS06880
gene id: 1089553:TPH_RS06880
uniprot id: K4LU88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

1089553:TPH RS09225
gene id: 1089553:TPH_RS09225
uniprot id: K4LGQ5
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1089553:TPH RS13130
gene id: 1089553:TPH_RS13130
uniprot id: K4LY02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

1089553:TPH RS11320
gene id: 1089553:TPH_RS11320
uniprot id: K4LHV2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1089553:TPH RS08510
gene id: 1089553:TPH_RS08510
uniprot id: K4LIM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS08000
gene id: 1089553:TPH_RS08000
uniprot id: K4LG52
names: Function
names: Similarity
messages: Belongs to the anti-sigma-factor family.
messages: Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.

1089553:TPH RS06930
gene id: 1089553:TPH_RS06930
uniprot id: K4LI09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

1089553:TPH RS08335
gene id: 1089553:TPH_RS08335
uniprot id: K4LIU2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS12695
gene id: 1089553:TPH_RS12695
uniprot id: K4LXM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1089553:TPH RS10585
gene id: 1089553:TPH_RS10585
uniprot id: K4LK64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
messages: Membrane

1089553:TPH RS10310
gene id: 1089553:TPH_RS10310
uniprot id: K4LHD8
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

1089553:TPH RS01635
gene id: 1089553:TPH_RS01635
uniprot id: K4LF06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

1089553:TPH RS11105
gene id: 1089553:TPH_RS11105
uniprot id: K4LHE7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity.

1089553:TPH RS11205
gene id: 1089553:TPH_RS11205
uniprot id: K4LKG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1089553:TPH RS10985
gene id: 1089553:TPH_RS10985
uniprot id: K4LHC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS00365
gene id: 1089553:TPH_RS00365
uniprot id: K4LED7
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS11635
gene id: 1089553:TPH_RS11635
uniprot id: K4LHP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1089553:TPH RS04975
gene id: 1089553:TPH_RS04975
uniprot id: K4LT35
names: Similarity
messages: Belongs to the asp23 family.

1089553:TPH RS11605
gene id: 1089553:TPH_RS11605
uniprot id: K4LKN0
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

1089553:TPH RS04255
gene id: 1089553:TPH_RS04255
uniprot id: K4LDZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1089553:TPH RS06265
gene id: 1089553:TPH_RS06265
uniprot id: K4LF43
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1089553:TPH RS14065
gene id: 1089553:TPH_RS14065
uniprot id: K4LJE1
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

1089553:TPH RS12635
gene id: 1089553:TPH_RS12635
uniprot id: K4LKX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1089553:TPH RS07695
gene id: 1089553:TPH_RS07695
uniprot id: K4LFV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

1089553:TPH RS03745
gene id: 1089553:TPH_RS03745
uniprot id: K4LDR0
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

1089553:TPH RS12495
gene id: 1089553:TPH_RS12495
uniprot id: K4LL37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS07230
gene id: 1089553:TPH_RS07230
uniprot id: K4LI66
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1089553:TPH RS03250
gene id: 1089553:TPH_RS03250
uniprot id: K4LFY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1089553:TPH RS06570
gene id: 1089553:TPH_RS06570
uniprot id: K4LHU1
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

1089553:TPH RS14000
gene id: 1089553:TPH_RS14000
uniprot id: K4LYI1
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS02040
gene id: 1089553:TPH_RS02040
uniprot id: K4LCY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1089553:TPH RS13720
gene id: 1089553:TPH_RS13720
uniprot id: K4LIV9
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

1089553:TPH RS09770
gene id: 1089553:TPH_RS09770
uniprot id: K4LJM7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1089553:TPH RS11665
gene id: 1089553:TPH_RS11665
uniprot id: K4LKD2
names: Similarity
messages: Belongs to the UPF0251 family.

1089553:TPH RS04495
gene id: 1089553:TPH_RS04495
uniprot id: K4LGC1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1089553:TPH RS04665
gene id: 1089553:TPH_RS04665
uniprot id: K4LDQ8
names: Similarity
messages: Belongs to the UPF0236 family.

1089553:TPH RS09925
gene id: 1089553:TPH_RS09925
uniprot id: K4LH25
names: Similarity
messages: Belongs to the UPF0175 family.

1089553:TPH RS09200
gene id: 1089553:TPH_RS09200
uniprot id: K4LJ04
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1089553:TPH RS11805
gene id: 1089553:TPH_RS11805
uniprot id: K4LKQ6
names: Similarity
messages: Belongs to the leucine-binding protein family.

1089553:TPH RS06905
gene id: 1089553:TPH_RS06905
uniprot id: K4LI03
names: Similarity
messages: Belongs to the CbxX/CfxQ family.

1089553:TPH RS06345
gene id: 1089553:TPH_RS06345
uniprot id: K4LTW9
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS06325
gene id: 1089553:TPH_RS06325
uniprot id: K4LHQ0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS05735
gene id: 1089553:TPH_RS05735
uniprot id: K4LH31
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS03270
gene id: 1089553:TPH_RS03270
uniprot id: K4LFY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

1089553:TPH RS07865
gene id: 1089553:TPH_RS07865
uniprot id: K4LFL5
names: Function
names: Similarity
names: Subunit
messages: Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.
messages: Belongs to the HutP family.
messages: Homohexamer.

1089553:TPH RS02430
gene id: 1089553:TPH_RS02430
uniprot id: K4LFE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family.
messages: Cytoplasm

1089553:TPH RS07710
gene id: 1089553:TPH_RS07710
uniprot id: K4LFE7
names: Similarity
messages: Belongs to the UbiD family.

1089553:TPH RS11925
gene id: 1089553:TPH_RS11925
uniprot id: K4LI68
names: Similarity
messages: Belongs to the UPF0107 family.

1089553:TPH RS03155
gene id: 1089553:TPH_RS03155
uniprot id: K4LS04
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1089553:TPH RS02495
gene id: 1089553:TPH_RS02495
uniprot id: K4LD66
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1089553:TPH RS03560
gene id: 1089553:TPH_RS03560
uniprot id: K4LD95
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

1089553:TPH RS13550
gene id: 1089553:TPH_RS13550
uniprot id: K4LIS7
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1089553:TPH RS12210
gene id: 1089553:TPH_RS12210
uniprot id: K4LKY5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

1089553:TPH RS07185
gene id: 1089553:TPH_RS07185
uniprot id: K4LF31
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
messages: Homodimer.
messages: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS02605
gene id: 1089553:TPH_RS02605
uniprot id: K4LF88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

1089553:TPH RS12775
gene id: 1089553:TPH_RS12775
uniprot id: K4LL87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1089553:TPH RS01380
gene id: 1089553:TPH_RS01380
uniprot id: K4LQY7
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS05380
gene id: 1089553:TPH_RS05380
uniprot id: K4LGY3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

1089553:TPH RS04395
gene id: 1089553:TPH_RS04395
uniprot id: K4LDM2
names: Similarity
messages: Belongs to the P(II) protein family.

1089553:TPH RS13990
gene id: 1089553:TPH_RS13990
uniprot id: K4LLL1
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1089553:TPH RS04445
gene id: 1089553:TPH_RS04445
uniprot id: K4LDM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1089553:TPH RS07760
gene id: 1089553:TPH_RS07760
uniprot id: K4LIG6
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1089553:TPH RS13600
gene id: 1089553:TPH_RS13600
uniprot id: K4LLE6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1089553:TPH RS00410
gene id: 1089553:TPH_RS00410
uniprot id: K4LQH1
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1089553:TPH RS05480
gene id: 1089553:TPH_RS05480
uniprot id: K4LGZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

1089553:TPH RS00130
gene id: 1089553:TPH_RS00130
uniprot id: K4LE06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

1089553:TPH RS00910
gene id: 1089553:TPH_RS00910
uniprot id: K4LCF8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1089553:TPH RS02405
gene id: 1089553:TPH_RS02405
uniprot id: K4LFE3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1089553:TPH RS00905
gene id: 1089553:TPH_RS00905
uniprot id: K4LEB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity.

1089553:TPH RS04830
gene id: 1089553:TPH_RS04830
uniprot id: K4LT12
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

1089553:TPH RS13170
gene id: 1089553:TPH_RS13170
uniprot id: K4LL96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

1089553:TPH RS03225
gene id: 1089553:TPH_RS03225
uniprot id: K4LFY3
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1089553:TPH RS08015
gene id: 1089553:TPH_RS08015
uniprot id: K4LFN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
messages: Homodimer.

1089553:TPH RS05410
gene id: 1089553:TPH_RS05410
uniprot id: K4LEQ9
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

1089553:TPH RS04090
gene id: 1089553:TPH_RS04090
uniprot id: K4LGE0
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1089553:TPH RS01330
gene id: 1089553:TPH_RS01330
uniprot id: K4LEU6
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

1089553:TPH RS04810
gene id: 1089553:TPH_RS04810
uniprot id: K4LGU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

1089553:TPH RS07010
gene id: 1089553:TPH_RS07010
uniprot id: K4LF00
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1089553:TPH RS01280
gene id: 1089553:TPH_RS01280
uniprot id: K4LQW6
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1089553:TPH RS06385
gene id: 1089553:TPH_RS06385
uniprot id: K4LHE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U4 family.
messages: Cell membrane
messages: Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR.

1089553:TPH RS05690
gene id: 1089553:TPH_RS05690
uniprot id: K4LEV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1089553:TPH RS06260
gene id: 1089553:TPH_RS06260
uniprot id: K4LHB7
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1089553:TPH RS03440
gene id: 1089553:TPH_RS03440
uniprot id: K4LDL8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1089553:TPH RS05615
gene id: 1089553:TPH_RS05615
uniprot id: K4LEU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

1089553:TPH RS06895
gene id: 1089553:TPH_RS06895
uniprot id: K4LHP6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1089553:TPH RS12780
gene id: 1089553:TPH_RS12780
uniprot id: K4LIC5
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1089553:TPH RS10770
gene id: 1089553:TPH_RS10770
uniprot id: K4LK86
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

1089553:TPH RS13570
gene id: 1089553:TPH_RS13570
uniprot id: K4LIT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1089553:TPH RS00835
gene id: 1089553:TPH_RS00835
uniprot id: K4LQN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

1089553:TPH RS04375
gene id: 1089553:TPH_RS04375
uniprot id: K4LG92
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1089553:TPH RS11750
gene id: 1089553:TPH_RS11750
uniprot id: K4LKQ1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1089553:TPH RS12080
gene id: 1089553:TPH_RS12080
uniprot id: K4LXB0
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

1089553:TPH RS10225
gene id: 1089553:TPH_RS10225
uniprot id: K4LJX1
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

1089553:TPH RS04350
gene id: 1089553:TPH_RS04350
uniprot id: K4LG87
names: Similarity
messages: Belongs to the P(II) protein family.

1089553:TPH RS07655
gene id: 1089553:TPH_RS07655
uniprot id: K4LUN8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1089553:TPH RS01595
gene id: 1089553:TPH_RS01595
uniprot id: K4LEN6
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1089553:TPH RS02015
gene id: 1089553:TPH_RS02015
uniprot id: K4LRC1
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS07195
gene id: 1089553:TPH_RS07195
uniprot id: K4LFK3
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

1089553:TPH RS02500
gene id: 1089553:TPH_RS02500
uniprot id: K4LRL5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1089553:TPH RS06175
gene id: 1089553:TPH_RS06175
uniprot id: K4LHM1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1089553:TPH RS04755
gene id: 1089553:TPH_RS04755
uniprot id: K4LSZ4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1089553:TPH RS04750
gene id: 1089553:TPH_RS04750
uniprot id: K4LE84
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

1089553:TPH RS12375
gene id: 1089553:TPH_RS12375
uniprot id: K4LXG1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1089553:TPH RS05390
gene id: 1089553:TPH_RS05390
uniprot id: K4LTE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CodY family.
messages: Cytoplasm
messages: DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.

1089553:TPH RS02435
gene id: 1089553:TPH_RS02435
uniprot id: K4LCQ7
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

1089553:TPH RS00280
gene id: 1089553:TPH_RS00280
uniprot id: K4LEC5
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1089553:TPH RS04365
gene id: 1089553:TPH_RS04365
uniprot id: K4LGJ9
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

1089553:TPH RS02905
gene id: 1089553:TPH_RS02905
uniprot id: K4LFH7
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1089553:TPH RS08535
gene id: 1089553:TPH_RS08535
uniprot id: K4LIM9
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1089553:TPH RS05740
gene id: 1089553:TPH_RS05740
uniprot id: K4LEW3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1089553:TPH RS08170
gene id: 1089553:TPH_RS08170
uniprot id: K4LIH2
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1089553:TPH RS09430
gene id: 1089553:TPH_RS09430
uniprot id: K4LGT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1089553:TPH RS06350
gene id: 1089553:TPH_RS06350
uniprot id: K4LHQ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS01750
gene id: 1089553:TPH_RS01750
uniprot id: K4LCD1
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

1089553:TPH RS13150
gene id: 1089553:TPH_RS13150
uniprot id: K4LIY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1089553:TPH RS10395
gene id: 1089553:TPH_RS10395
uniprot id: K4LH40
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1089553:TPH RS04890
gene id: 1089553:TPH_RS04890
uniprot id: K4LGK5
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS07730
gene id: 1089553:TPH_RS07730
uniprot id: K4LIG1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

1089553:TPH RS12395
gene id: 1089553:TPH_RS12395
uniprot id: K4LIF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS03030
gene id: 1089553:TPH_RS03030
uniprot id: K4LD21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

1089553:TPH RS11560
gene id: 1089553:TPH_RS11560
uniprot id: K4LHN4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1089553:TPH RS08235
gene id: 1089553:TPH_RS08235
uniprot id: K4LIS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1089553:TPH RS02290
gene id: 1089553:TPH_RS02290
uniprot id: K4LD28
names: Similarity
messages: Belongs to the ComB family.

1089553:TPH RS10700
gene id: 1089553:TPH_RS10700
uniprot id: K4LJX9
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1089553:TPH RS05105
gene id: 1089553:TPH_RS05105
uniprot id: K4LT59
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS00420
gene id: 1089553:TPH_RS00420
uniprot id: K4LBS2
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1089553:TPH RS02115
gene id: 1089553:TPH_RS02115
uniprot id: K4LEZ2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1089553:TPH RS08065
gene id: 1089553:TPH_RS08065
uniprot id: K4LFP7
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS05640
gene id: 1089553:TPH_RS05640
uniprot id: K4LEU7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1089553:TPH RS07190
gene id: 1089553:TPH_RS07190
uniprot id: K4LHV3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS12665
gene id: 1089553:TPH_RS12665
uniprot id: K4LIJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1089553:TPH RS12300
gene id: 1089553:TPH_RS12300
uniprot id: K4LXE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS12335
gene id: 1089553:TPH_RS12335
uniprot id: K4LI28
names: Subcellular Location Annotation
messages: Cytoplasm

1089553:TPH RS02360
gene id: 1089553:TPH_RS02360
uniprot id: K4LCP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1089553:TPH RS13740
gene id: 1089553:TPH_RS13740
uniprot id: K4LLU7
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1089553:TPH RS06430
gene id: 1089553:TPH_RS06430
uniprot id: K4LEN3
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

1089553:TPH RS06850
gene id: 1089553:TPH_RS06850
uniprot id: K4LFE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

1089553:TPH RS09240
gene id: 1089553:TPH_RS09240
uniprot id: K4LGB3
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

1089553:TPH RS02485
gene id: 1089553:TPH_RS02485
uniprot id: K4LCR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

1089553:TPH RS02475
gene id: 1089553:TPH_RS02475
uniprot id: K4LRL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1089553:TPH RS09775
gene id: 1089553:TPH_RS09775
uniprot id: K4LY64
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1089553:TPH RS06465
gene id: 1089553:TPH_RS06465
uniprot id: K4LF80
names: Similarity
messages: Belongs to the UPF0235 family.

1089553:TPH RS10120
gene id: 1089553:TPH_RS10120
uniprot id: K4LH61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS06540
gene id: 1089553:TPH_RS06540
uniprot id: K4LU14
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1089553:TPH RS02885
gene id: 1089553:TPH_RS02885
uniprot id: K4LDF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

1089553:TPH RS04030
gene id: 1089553:TPH_RS04030
uniprot id: K4LDV6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably interacts with PlsX.

1089553:TPH RS00405
gene id: 1089553:TPH_RS00405
uniprot id: K4LC78
names: Similarity
messages: Belongs to the peptidase S16 family.

1089553:TPH RS00010
gene id: 1089553:TPH_RS00010
uniprot id: K4LE44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1089553:TPH RS05400
gene id: 1089553:TPH_RS05400
uniprot id: K4LE56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

1089553:TPH RS05090
gene id: 1089553:TPH_RS05090
uniprot id: K4LDX7
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

1089553:TPH RS02710
gene id: 1089553:TPH_RS02710
uniprot id: K4LDC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1089553:TPH RS04390
gene id: 1089553:TPH_RS04390
uniprot id: K4LGK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS08085
gene id: 1089553:TPH_RS08085
uniprot id: K4LIQ6
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cytoplasm
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

1089553:TPH RS05710
gene id: 1089553:TPH_RS05710
uniprot id: K4LH28
names: Similarity
messages: Belongs to the peptidase M16 family.

1089553:TPH RS08420
gene id: 1089553:TPH_RS08420
uniprot id: K4LV45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1089553:TPH RS05550
gene id: 1089553:TPH_RS05550
uniprot id: K4LE77
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

1089553:TPH RS10750
gene id: 1089553:TPH_RS10750
uniprot id: K4LH93
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1089553:TPH RS05095
gene id: 1089553:TPH_RS05095
uniprot id: K4LGP4
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

1089553:TPH RS13670
gene id: 1089553:TPH_RS13670
uniprot id: K4LIU7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1089553:TPH RS05415
gene id: 1089553:TPH_RS05415
uniprot id: K4LTE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

1089553:TPH RS14070
gene id: 1089553:TPH_RS14070
uniprot id: K4LYJ6
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).
messages: Homodimer.
messages: In the C-terminal section; belongs to the MurCDEF family.

1089553:TPH RS08115
gene id: 1089553:TPH_RS08115
uniprot id: K4LFQ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

1089553:TPH RS07640
gene id: 1089553:TPH_RS07640
uniprot id: K4LFD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer.

1089553:TPH RS09845
gene id: 1089553:TPH_RS09845
uniprot id: K4LJP2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

1089553:TPH RS11815
gene id: 1089553:TPH_RS11815
uniprot id: K4LKF6
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS12640
gene id: 1089553:TPH_RS12640
uniprot id: K4LIJ3
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1089553:TPH RS05085
gene id: 1089553:TPH_RS05085
uniprot id: K4LGZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1089553:TPH RS00215
gene id: 1089553:TPH_RS00215
uniprot id: K4LQE8
names: Function
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

1089553:TPH RS05125
gene id: 1089553:TPH_RS05125
uniprot id: K4LGQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

1089553:TPH RS13815
gene id: 1089553:TPH_RS13815
uniprot id: K4LLW1
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1089553:TPH RS04465
gene id: 1089553:TPH_RS04465
uniprot id: K4LDN2
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS13605
gene id: 1089553:TPH_RS13605
uniprot id: K4LJ57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1089553:TPH RS00125
gene id: 1089553:TPH_RS00125
uniprot id: K4LBM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

1089553:TPH RS11505
gene id: 1089553:TPH_RS11505
uniprot id: K4LKL4
names: Similarity
messages: Belongs to the peptidase S14 family.

1089553:TPH RS01830
gene id: 1089553:TPH_RS01830
uniprot id: K4LET5
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1089553:TPH RS09130
gene id: 1089553:TPH_RS09130
uniprot id: K4LIY8
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

1089553:TPH RS02560
gene id: 1089553:TPH_RS02560
uniprot id: K4LD74
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS01155
gene id: 1089553:TPH_RS01155
uniprot id: K4LC22
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1089553:TPH RS01390
gene id: 1089553:TPH_RS01390
uniprot id: K4LC58
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1089553:TPH RS01885
gene id: 1089553:TPH_RS01885
uniprot id: K4LCW4
names: Activity Regulation
names: Function
names: Similarity
messages: Appears to be allosterically activated by the binding of pArg-containing polypeptides to the pArg-binding pocket localized in the C-terminal domain of McsB.
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Catalyzes the specific phosphorylation of arginine residues in proteins.

1089553:TPH RS11285
gene id: 1089553:TPH_RS11285
uniprot id: K4LHI2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

1089553:TPH RS03500
gene id: 1089553:TPH_RS03500
uniprot id: K4LS55
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

1089553:TPH RS10475
gene id: 1089553:TPH_RS10475
uniprot id: K4LHH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1089553:TPH RS11095
gene id: 1089553:TPH_RS11095
uniprot id: K4LWQ8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

1089553:TPH RS04185
gene id: 1089553:TPH_RS04185
uniprot id: K4LSL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1089553:TPH RS08855
gene id: 1089553:TPH_RS08855
uniprot id: K4LG34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

1089553:TPH RS07445
gene id: 1089553:TPH_RS07445
uniprot id: K4LI10
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

1089553:TPH RS04035
gene id: 1089553:TPH_RS04035
uniprot id: K4LSH4
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

1089553:TPH RS13575
gene id: 1089553:TPH_RS13575
uniprot id: K4LLE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1089553:TPH RS03045
gene id: 1089553:TPH_RS03045
uniprot id: K4LRZ0
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

1089553:TPH RS02225
gene id: 1089553:TPH_RS02225
uniprot id: K4LFB1
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS03290
gene id: 1089553:TPH_RS03290
uniprot id: K4LS22
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1089553:TPH RS12730
gene id: 1089553:TPH_RS12730
uniprot id: K4LIB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1089553:TPH RS02960
gene id: 1089553:TPH_RS02960
uniprot id: K4LFI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1089553:TPH RS13035
gene id: 1089553:TPH_RS13035
uniprot id: K4LIK0
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS08890
gene id: 1089553:TPH_RS08890
uniprot id: K4LGJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

1089553:TPH RS04575
gene id: 1089553:TPH_RS04575
uniprot id: K4LE48
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

1089553:TPH RS05500
gene id: 1089553:TPH_RS05500
uniprot id: K4LE71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

1089553:TPH RS13465
gene id: 1089553:TPH_RS13465
uniprot id: K4LIR3
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

1089553:TPH RS01360
gene id: 1089553:TPH_RS01360
uniprot id: K4LEV2
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS08655
gene id: 1089553:TPH_RS08655
uniprot id: K4LJ03
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS07750
gene id: 1089553:TPH_RS07750
uniprot id: K4LFW8
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

1089553:TPH RS04215
gene id: 1089553:TPH_RS04215
uniprot id: K4LGG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

1089553:TPH RS04795
gene id: 1089553:TPH_RS04795
uniprot id: K4LGI2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1089553:TPH RS03110
gene id: 1089553:TPH_RS03110
uniprot id: K4LFW6
names: Similarity
messages: Belongs to the UPF0145 family.

1089553:TPH RS13300
gene id: 1089553:TPH_RS13300
uniprot id: K4LIP0
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

1089553:TPH RS06530
gene id: 1089553:TPH_RS06530
uniprot id: K4LHH0
names: Similarity
messages: Belongs to the glutamate synthase family.

1089553:TPH RS12560
gene id: 1089553:TPH_RS12560
uniprot id: K4LII0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS05285
gene id: 1089553:TPH_RS05285
uniprot id: K4LEN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.
messages: Cytoplasm
messages: Gas vesicle
messages: Vesicle

1089553:TPH RS06445
gene id: 1089553:TPH_RS06445
uniprot id: K4LTZ3
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1089553:TPH RS12740
gene id: 1089553:TPH_RS12740
uniprot id: K4LIL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1089553:TPH RS05505
gene id: 1089553:TPH_RS05505
uniprot id: K4LH00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

1089553:TPH RS08145
gene id: 1089553:TPH_RS08145
uniprot id: K4LIG8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS05420
gene id: 1089553:TPH_RS05420
uniprot id: K4LH95
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

1089553:TPH RS09220
gene id: 1089553:TPH_RS09220
uniprot id: K4LJ09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

1089553:TPH RS13410
gene id: 1089553:TPH_RS13410
uniprot id: K4LIQ5
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1089553:TPH RS06450
gene id: 1089553:TPH_RS06450
uniprot id: K4LHS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

1089553:TPH RS05510
gene id: 1089553:TPH_RS05510
uniprot id: K4LES5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

1089553:TPH RS03275
gene id: 1089553:TPH_RS03275
uniprot id: K4LD54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1089553:TPH RS02785
gene id: 1089553:TPH_RS02785
uniprot id: K4LRU9
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS13315
gene id: 1089553:TPH_RS13315
uniprot id: K4LLM7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

1089553:TPH RS11955
gene id: 1089553:TPH_RS11955
uniprot id: K4LX85
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.

1089553:TPH RS09885
gene id: 1089553:TPH_RS09885
uniprot id: K4LH17
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1089553:TPH RS07840
gene id: 1089553:TPH_RS07840
uniprot id: K4LFK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1089553:TPH RS05485
gene id: 1089553:TPH_RS05485
uniprot id: K4LES0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

1089553:TPH RS11555
gene id: 1089553:TPH_RS11555
uniprot id: K4LKM3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1089553:TPH RS13760
gene id: 1089553:TPH_RS13760
uniprot id: K4LYC8
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1089553:TPH RS08545
gene id: 1089553:TPH_RS08545
uniprot id: K4LV69
names: Similarity
messages: Belongs to the UPF0340 family.

1089553:TPH RS05770
gene id: 1089553:TPH_RS05770
uniprot id: K4LH35
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

1089553:TPH RS13080
gene id: 1089553:TPH_RS13080
uniprot id: K4LLJ4
names: Similarity
messages: Belongs to the peptidase A31 family.

1089553:TPH RS10760
gene id: 1089553:TPH_RS10760
uniprot id: K4LHL3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS07530
gene id: 1089553:TPH_RS07530
uniprot id: K4LUK9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1089553:TPH RS05590
gene id: 1089553:TPH_RS05590
uniprot id: K4LET8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS05580
gene id: 1089553:TPH_RS05580
uniprot id: K4LE81
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1089553:TPH RS00295
gene id: 1089553:TPH_RS00295
uniprot id: K4LC64
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

1089553:TPH RS06460
gene id: 1089553:TPH_RS06460
uniprot id: K4LHF6
names: Similarity
messages: Belongs to the YggT family.

1089553:TPH RS14130
gene id: 1089553:TPH_RS14130
uniprot id: K4LYL2
names: Similarity
messages: Belongs to the peptidase S1 family.

1089553:TPH RS03390
gene id: 1089553:TPH_RS03390
uniprot id: K4LS38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

1089553:TPH RS13445
gene id: 1089553:TPH_RS13445
uniprot id: K4LJ29
names: Similarity
messages: Belongs to the UPF0597 family.

1089553:TPH RS08590
gene id: 1089553:TPH_RS08590
uniprot id: K4LGE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1089553:TPH RS13655
gene id: 1089553:TPH_RS13655
uniprot id: K4LJ64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

1089553:TPH RS04705
gene id: 1089553:TPH_RS04705
uniprot id: K4LSY3
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1089553:TPH RS02995
gene id: 1089553:TPH_RS02995
uniprot id: K4LRY4
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

1089553:TPH RS04085
gene id: 1089553:TPH_RS04085
uniprot id: K4LSI6
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1089553:TPH RS01780
gene id: 1089553:TPH_RS01780
uniprot id: K4LES3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS03635
gene id: 1089553:TPH_RS03635
uniprot id: K4LDA3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1089553:TPH RS04250
gene id: 1089553:TPH_RS04250
uniprot id: K4LG65
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

1089553:TPH RS12940
gene id: 1089553:TPH_RS12940
uniprot id: K4LLH8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1089553:TPH RS07125
gene id: 1089553:TPH_RS07125
uniprot id: K4LUD9
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS12385
gene id: 1089553:TPH_RS12385
uniprot id: K4LI39
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1089553:TPH RS06170
gene id: 1089553:TPH_RS06170
uniprot id: K4LTT0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1089553:TPH RS06285
gene id: 1089553:TPH_RS06285
uniprot id: K4LHC3
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

1089553:TPH RS01210
gene id: 1089553:TPH_RS01210
uniprot id: K4LCK6
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS05115
gene id: 1089553:TPH_RS05115
uniprot id: K4LH01
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1089553:TPH RS02260
gene id: 1089553:TPH_RS02260
uniprot id: K4LF15
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS00830
gene id: 1089553:TPH_RS00830
uniprot id: K4LCE6
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

1089553:TPH RS08905
gene id: 1089553:TPH_RS08905
uniprot id: K4LG45
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1089553:TPH RS05265
gene id: 1089553:TPH_RS05265
uniprot id: K4LTC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gas vesicle GvpA family.
messages: Gas vesicle shell
messages: Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. During planktonic growth they allow positioning of the organism at a favorable depth for light or nutrient acquisition. GvpA forms the protein shell.
messages: The gas vesicle shell is 2 nm thick and consists of a single layer of this protein. It forms helical ribs nearly perpendicular to the long axis of the vesicle.

1089553:TPH RS03985
gene id: 1089553:TPH_RS03985
uniprot id: K4LDU7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1089553:TPH RS11090
gene id: 1089553:TPH_RS11090
uniprot id: K4LHR7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1089553:TPH RS12625
gene id: 1089553:TPH_RS12625
uniprot id: K4LL57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1089553:TPH RS02860
gene id: 1089553:TPH_RS02860
uniprot id: K4LDE6
names: Similarity
messages: Belongs to the FlgM family.

1089553:TPH RS10415
gene id: 1089553:TPH_RS10415
uniprot id: K4LK41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

1089553:TPH RS05665
gene id: 1089553:TPH_RS05665
uniprot id: K4LEV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1089553:TPH RS08805
gene id: 1089553:TPH_RS08805
uniprot id: K4LG26
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

1089553:TPH RS04910
gene id: 1089553:TPH_RS04910
uniprot id: K4LDU9
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

1089553:TPH RS11975
gene id: 1089553:TPH_RS11975
uniprot id: K4LI77
names: Similarity
messages: Belongs to the CdaR family.

1089553:TPH RS10425
gene id: 1089553:TPH_RS10425
uniprot id: K4LJU6
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS10730
gene id: 1089553:TPH_RS10730
uniprot id: K4LHK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1089553:TPH RS12605
gene id: 1089553:TPH_RS12605
uniprot id: K4LI86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1089553:TPH RS00335
gene id: 1089553:TPH_RS00335
uniprot id: K4LQG3
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS13350
gene id: 1089553:TPH_RS13350
uniprot id: K4LY44
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

1089553:TPH RS13665
gene id: 1089553:TPH_RS13665
uniprot id: K4LLT2
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1089553:TPH RS07845
gene id: 1089553:TPH_RS07845
uniprot id: K4LIC3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1089553:TPH RS04765
gene id: 1089553:TPH_RS04765
uniprot id: K4LDS4
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

1089553:TPH RS06390
gene id: 1089553:TPH_RS06390
uniprot id: K4LF68
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1089553:TPH RS00820
gene id: 1089553:TPH_RS00820
uniprot id: K4LBX5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

1089553:TPH RS12840
gene id: 1089553:TPH_RS12840
uniprot id: K4LIP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1089553:TPH RS10050
gene id: 1089553:TPH_RS10050
uniprot id: K4LJT5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methylaspartate mutase GlmE subunit family.
messages: Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
messages: Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS04245
gene id: 1089553:TPH_RS04245
uniprot id: K4LDJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1089553:TPH RS01910
gene id: 1089553:TPH_RS01910
uniprot id: K4LEV0
names: Similarity
messages: Belongs to the class-I fumarase family.

1089553:TPH RS08570
gene id: 1089553:TPH_RS08570
uniprot id: K4LV73
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1089553:TPH RS13415
gene id: 1089553:TPH_RS13415
uniprot id: K4LLC5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS07855
gene id: 1089553:TPH_RS07855
uniprot id: K4LUU5
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1089553:TPH RS06360
gene id: 1089553:TPH_RS06360
uniprot id: K4LHD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1089553:TPH RS06680
gene id: 1089553:TPH_RS06680
uniprot id: K4LFB8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1089553:TPH RS07145
gene id: 1089553:TPH_RS07145
uniprot id: K4LFJ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1089553:TPH RS13565
gene id: 1089553:TPH_RS13565
uniprot id: K4LY87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS06190
gene id: 1089553:TPH_RS06190
uniprot id: K4LF30
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

1089553:TPH RS03840
gene id: 1089553:TPH_RS03840
uniprot id: K4LDS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

1089553:TPH RS06425
gene id: 1089553:TPH_RS06425
uniprot id: K4LHR6
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

1089553:TPH RS03490
gene id: 1089553:TPH_RS03490
uniprot id: K4LFR4
names: Similarity
messages: Belongs to the EutP/PduV family.

1089553:TPH RS01090
gene id: 1089553:TPH_RS01090
uniprot id: K4LEE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1089553:TPH RS06410
gene id: 1089553:TPH_RS06410
uniprot id: K4LHE6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1089553:TPH RS07755
gene id: 1089553:TPH_RS07755
uniprot id: K4LUR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1089553:TPH RS06240
gene id: 1089553:TPH_RS06240
uniprot id: K4LF38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1089553:TPH RS08095
gene id: 1089553:TPH_RS08095
uniprot id: K4LIG2
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1089553:TPH RS08105
gene id: 1089553:TPH_RS08105
uniprot id: K4LUY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS11835
gene id: 1089553:TPH_RS11835
uniprot id: K4LHS9
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

1089553:TPH RS05385
gene id: 1089553:TPH_RS05385
uniprot id: K4LEQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

1089553:TPH RS09830
gene id: 1089553:TPH_RS09830
uniprot id: K4LJD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sbp family.
messages: Cell membrane

1089553:TPH RS05355
gene id: 1089553:TPH_RS05355
uniprot id: K4LGX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic Ku family.
messages: Homodimer. Interacts with LigD.
messages: With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

1089553:TPH RS02075
gene id: 1089553:TPH_RS02075
uniprot id: K4LRD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

1089553:TPH RS06875
gene id: 1089553:TPH_RS06875
uniprot id: K4LFF0
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

1089553:TPH RS14240
gene id: 1089553:TPH_RS14240
uniprot id: K4LJ27
names: Similarity
messages: Belongs to the UPF0236 family.

1089553:TPH RS05630
gene id: 1089553:TPH_RS05630
uniprot id: K4LE89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1089553:TPH RS15790
gene id: 1089553:TPH_RS15790
uniprot id: K4LLT8
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

1089553:TPH RS11245
gene id: 1089553:TPH_RS11245
uniprot id: K4LHU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS07300
gene id: 1089553:TPH_RS07300
uniprot id: K4LUH1
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

1089553:TPH RS06740
gene id: 1089553:TPH_RS06740
uniprot id: K4LHW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

1089553:TPH RS13500
gene id: 1089553:TPH_RS13500
uniprot id: K4LJ39
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS13680
gene id: 1089553:TPH_RS13680
uniprot id: K4LJ68
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1089553:TPH RS02110
gene id: 1089553:TPH_RS02110
uniprot id: K4LCK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1089553:TPH RS12130
gene id: 1089553:TPH_RS12130
uniprot id: K4LXC1
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

1089553:TPH RS06885
gene id: 1089553:TPH_RS06885
uniprot id: K4LHZ8
names: Similarity
messages: Belongs to the fabD family.

1089553:TPH RS12770
gene id: 1089553:TPH_RS12770
uniprot id: K4LXP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1089553:TPH RS12810
gene id: 1089553:TPH_RS12810
uniprot id: K4LL09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1089553:TPH RS06520
gene id: 1089553:TPH_RS06520
uniprot id: K4LHT3
names: Similarity
messages: Belongs to the glutamine synthetase family.

1089553:TPH RS03405
gene id: 1089553:TPH_RS03405
uniprot id: K4LFP9
names: Similarity
messages: Belongs to the sigma-54 factor family.

1089553:TPH RS00785
gene id: 1089553:TPH_RS00785
uniprot id: K4LQM6
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1089553:TPH RS12720
gene id: 1089553:TPH_RS12720
uniprot id: K4LXN1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

1089553:TPH RS13210
gene id: 1089553:TPH_RS13210
uniprot id: K4LLL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

1089553:TPH RS00455
gene id: 1089553:TPH_RS00455
uniprot id: K4LC86
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1089553:TPH RS08565
gene id: 1089553:TPH_RS08565
uniprot id: K4LGE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

1089553:TPH RS07555
gene id: 1089553:TPH_RS07555
uniprot id: K4LUL5
names: Similarity
messages: Belongs to the HdrA family.

1089553:TPH RS03310
gene id: 1089553:TPH_RS03310
uniprot id: K4LDK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.

1089553:TPH RS07785
gene id: 1089553:TPH_RS07785
uniprot id: K4LIH0
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1089553:TPH RS10130
gene id: 1089553:TPH_RS10130
uniprot id: K4LJV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS03435
gene id: 1089553:TPH_RS03435
uniprot id: K4LFQ3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1089553:TPH RS11280
gene id: 1089553:TPH_RS11280
uniprot id: K4LKH6
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

1089553:TPH RS02740
gene id: 1089553:TPH_RS02740
uniprot id: K4LFP8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

1089553:TPH RS06815
gene id: 1089553:TPH_RS06815
uniprot id: K4LEW4
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

1089553:TPH RS13795
gene id: 1089553:TPH_RS13795
uniprot id: K4LIX2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS00920
gene id: 1089553:TPH_RS00920
uniprot id: K4LEM5
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1089553:TPH RS04530
gene id: 1089553:TPH_RS04530
uniprot id: K4LGN6
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

1089553:TPH RS02755
gene id: 1089553:TPH_RS02755
uniprot id: K4LDD2
names: Similarity
messages: Belongs to the peptidase A24 family.

1089553:TPH RS02775
gene id: 1089553:TPH_RS02775
uniprot id: K4LFF8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

1089553:TPH RS09135
gene id: 1089553:TPH_RS09135
uniprot id: K4LGN9
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1089553:TPH RS12790
gene id: 1089553:TPH_RS12790
uniprot id: K4LIM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1089553:TPH RS12230
gene id: 1089553:TPH_RS12230
uniprot id: K4LIB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS06185
gene id: 1089553:TPH_RS06185
uniprot id: K4LHA4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

1089553:TPH RS07425
gene id: 1089553:TPH_RS07425
uniprot id: K4LFP5
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

1089553:TPH RS11890
gene id: 1089553:TPH_RS11890
uniprot id: K4LHT8
names: Similarity
messages: Belongs to the EamA transporter family.

1089553:TPH RS12895
gene id: 1089553:TPH_RS12895
uniprot id: K4LLG6
names: Similarity
messages: Belongs to the UPF0236 family.

1089553:TPH RS04430
gene id: 1089553:TPH_RS04430
uniprot id: K4LE16
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1089553:TPH RS03305
gene id: 1089553:TPH_RS03305
uniprot id: K4LFN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

1089553:TPH RS11915
gene id: 1089553:TPH_RS11915
uniprot id: K4LHU2
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.

1089553:TPH RS03130
gene id: 1089553:TPH_RS03130
uniprot id: K4LS01
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1089553:TPH RS13635
gene id: 1089553:TPH_RS13635
uniprot id: K4LYA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS04600
gene id: 1089553:TPH_RS04600
uniprot id: K4LE53
names: Similarity
messages: Belongs to the acylphosphatase family.
messages: Belongs to the carbamoyltransferase HypF family.

1089553:TPH RS13050
gene id: 1089553:TPH_RS13050
uniprot id: K4LXY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
messages: Membrane

1089553:TPH RS01755
gene id: 1089553:TPH_RS01755
uniprot id: K4LER8
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1089553:TPH RS02950
gene id: 1089553:TPH_RS02950
uniprot id: K4LFT6
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

1089553:TPH RS04155
gene id: 1089553:TPH_RS04155
uniprot id: K4LDX5
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

1089553:TPH RS04025
gene id: 1089553:TPH_RS04025
uniprot id: K4LG17
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

1089553:TPH RS11675
gene id: 1089553:TPH_RS11675
uniprot id: K4LKN9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1089553:TPH RS12680
gene id: 1089553:TPH_RS12680
uniprot id: K4LIA3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1089553:TPH RS03615
gene id: 1089553:TPH_RS03615
uniprot id: K4LFT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1089553:TPH RS05185
gene id: 1089553:TPH_RS05185
uniprot id: K4LT74
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

1089553:TPH RS08870
gene id: 1089553:TPH_RS08870
uniprot id: K4LVD9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

1089553:TPH RS00135
gene id: 1089553:TPH_RS00135
uniprot id: K4LC40
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpB RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpA.
messages: Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H).

1089553:TPH RS08245
gene id: 1089553:TPH_RS08245
uniprot id: K4LII1
names: Similarity
messages: Belongs to the peptidase U62 family.

1089553:TPH RS10125
gene id: 1089553:TPH_RS10125
uniprot id: K4LW53
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1089553:TPH RS08925
gene id: 1089553:TPH_RS08925
uniprot id: K4LJ55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS00315
gene id: 1089553:TPH_RS00315
uniprot id: K4LBQ6
names: Similarity
messages: Belongs to the EamA transporter family.

1089553:TPH RS09560
gene id: 1089553:TPH_RS09560
uniprot id: K4LVT1
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

1089553:TPH RS01990
gene id: 1089553:TPH_RS01990
uniprot id: K4LRB6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1089553:TPH RS06565
gene id: 1089553:TPH_RS06565
uniprot id: K4LU19
names: Similarity
messages: Belongs to the UPF0045 family.

1089553:TPH RS00065
gene id: 1089553:TPH_RS00065
uniprot id: K4LDX1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1089553:TPH RS13475
gene id: 1089553:TPH_RS13475
uniprot id: K4LJ34
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS09750
gene id: 1089553:TPH_RS09750
uniprot id: K4LGL4
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1089553:TPH RS04180
gene id: 1089553:TPH_RS04180
uniprot id: K4LDX9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

1089553:TPH RS01860
gene id: 1089553:TPH_RS01860
uniprot id: K4LCW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

1089553:TPH RS10690
gene id: 1089553:TPH_RS10690
uniprot id: K4LK74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1089553:TPH RS08150
gene id: 1089553:TPH_RS08150
uniprot id: K4LG77
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

1089553:TPH RS02265
gene id: 1089553:TPH_RS02265
uniprot id: K4LD22
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

1089553:TPH RS07020
gene id: 1089553:TPH_RS07020
uniprot id: K4LFH3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1089553:TPH RS05785
gene id: 1089553:TPH_RS05785
uniprot id: K4LHF0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

1089553:TPH RS05460
gene id: 1089553:TPH_RS05460
uniprot id: K4LER6
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

1089553:TPH RS09805
gene id: 1089553:TPH_RS09805
uniprot id: K4LJC8
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1089553:TPH RS13215
gene id: 1089553:TPH_RS13215
uniprot id: K4LIM7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1089553:TPH RS05145
gene id: 1089553:TPH_RS05145
uniprot id: K4LDY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS03050
gene id: 1089553:TPH_RS03050
uniprot id: K4LFV6
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

1089553:TPH RS08875
gene id: 1089553:TPH_RS08875
uniprot id: K4LJ47
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

1089553:TPH RS12715
gene id: 1089553:TPH_RS12715
uniprot id: K4LIK8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1089553:TPH RS05475
gene id: 1089553:TPH_RS05475
uniprot id: K4LE67
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

1089553:TPH RS07630
gene id: 1089553:TPH_RS07630
uniprot id: K4LUN2
names: Similarity
messages: Belongs to the Ahb/Nir family.

1089553:TPH RS03220
gene id: 1089553:TPH_RS03220
uniprot id: K4LS09
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

1089553:TPH RS02120
gene id: 1089553:TPH_RS02120
uniprot id: K4LCZ9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1089553:TPH RS04660
gene id: 1089553:TPH_RS04660
uniprot id: K4LGR3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1089553:TPH RS10715
gene id: 1089553:TPH_RS10715
uniprot id: K4LK78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1089553:TPH RS08415
gene id: 1089553:TPH_RS08415
uniprot id: K4LGB9
names: Similarity
messages: Belongs to the UPF0473 family.

1089553:TPH RS12755
gene id: 1089553:TPH_RS12755
uniprot id: K4LIB8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1089553:TPH RS12795
gene id: 1089553:TPH_RS12795
uniprot id: K4LXP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1089553:TPH RS07260
gene id: 1089553:TPH_RS07260
uniprot id: K4LF49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1089553:TPH RS10465
gene id: 1089553:TPH_RS10465
uniprot id: K4LH53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1089553:TPH RS07205
gene id: 1089553:TPH_RS07205
uniprot id: K4LI60
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS03915
gene id: 1089553:TPH_RS03915
uniprot id: K4LGB0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

1089553:TPH RS00210
gene id: 1089553:TPH_RS00210
uniprot id: K4LC53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

1089553:TPH RS06925
gene id: 1089553:TPH_RS06925
uniprot id: K4LY64
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1089553:TPH RS05365
gene id: 1089553:TPH_RS05365
uniprot id: K4LTE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1089553:TPH RS11895
gene id: 1089553:TPH_RS11895
uniprot id: K4LKH2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1089553:TPH RS10085
gene id: 1089553:TPH_RS10085
uniprot id: K4LGU3
names: Similarity
messages: Belongs to the proline racemase family.

1089553:TPH RS03410
gene id: 1089553:TPH_RS03410
uniprot id: K4LDL6
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1089553:TPH RS08130
gene id: 1089553:TPH_RS08130
uniprot id: K4LUY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1089553:TPH RS12990
gene id: 1089553:TPH_RS12990
uniprot id: K4LIV5
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1089553:TPH RS12200
gene id: 1089553:TPH_RS12200
uniprot id: K4LIB5
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS12845
gene id: 1089553:TPH_RS12845
uniprot id: K4LXQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1089553:TPH RS08165
gene id: 1089553:TPH_RS08165
uniprot id: K4LFR6
names: Similarity
messages: Belongs to the asp23 family.

1089553:TPH RS13835
gene id: 1089553:TPH_RS13835
uniprot id: K4LYE3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1089553:TPH RS00300
gene id: 1089553:TPH_RS00300
uniprot id: K4LQF9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS01505
gene id: 1089553:TPH_RS01505
uniprot id: K4LEY5
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1089553:TPH RS06330
gene id: 1089553:TPH_RS06330
uniprot id: K4LEL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1089553:TPH RS14030
gene id: 1089553:TPH_RS14030
uniprot id: K4LJ22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1089553:TPH RS02095
gene id: 1089553:TPH_RS02095
uniprot id: K4LCZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

1089553:TPH RS11825
gene id: 1089553:TPH_RS11825
uniprot id: K4LX59
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

1089553:TPH RS07510
gene id: 1089553:TPH_RS07510
uniprot id: K4LIB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

1089553:TPH RS04805
gene id: 1089553:TPH_RS04805
uniprot id: K4LT04
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

1089553:TPH RS13145
gene id: 1089553:TPH_RS13145
uniprot id: K4LL94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1089553:TPH RS01640
gene id: 1089553:TPH_RS01640
uniprot id: K4LCA9
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS06305
gene id: 1089553:TPH_RS06305
uniprot id: K4LEL0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1089553:TPH RS05680
gene id: 1089553:TPH_RS05680
uniprot id: K4LE97
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1089553:TPH RS13590
gene id: 1089553:TPH_RS13590
uniprot id: K4LLR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1089553:TPH RS06245
gene id: 1089553:TPH_RS06245
uniprot id: K4LTU6
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

1089553:TPH RS10325
gene id: 1089553:TPH_RS10325
uniprot id: K4LH27
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

1089553:TPH RS00015
gene id: 1089553:TPH_RS00015
uniprot id: K4LBI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1089553:TPH RS00860
gene id: 1089553:TPH_RS00860
uniprot id: K4LCF0
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

1089553:TPH RS06275
gene id: 1089553:TPH_RS06275
uniprot id: K4LHN8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1089553:TPH RS01665
gene id: 1089553:TPH_RS01665
uniprot id: K4LCB3
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

1089553:TPH RS06635
gene id: 1089553:TPH_RS06635
uniprot id: K4LFA9
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1089553:TPH RS14215
gene id: 1089553:TPH_RS14215
uniprot id: K4LYM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1089553:TPH RS11265
gene id: 1089553:TPH_RS11265
uniprot id: K4LK59
names: Similarity
messages: Belongs to the peptidase A31 family.

1089553:TPH RS06765
gene id: 1089553:TPH_RS06765
uniprot id: K4LHX4
names: Similarity
messages: Belongs to the arginase family.

1089553:TPH RS01400
gene id: 1089553:TPH_RS01400
uniprot id: K4LCN4
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS05515
gene id: 1089553:TPH_RS05515
uniprot id: K4LTG2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

1089553:TPH RS02145
gene id: 1089553:TPH_RS02145
uniprot id: K4LD04
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

1089553:TPH RS09640
gene id: 1089553:TPH_RS09640
uniprot id: K4LVU7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

1089553:TPH RS01980
gene id: 1089553:TPH_RS01980
uniprot id: K4LEW6
names: Similarity
messages: Belongs to the PspA/IM30 family.

1089553:TPH RS12660
gene id: 1089553:TPH_RS12660
uniprot id: K4LKX9
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1089553:TPH RS04535
gene id: 1089553:TPH_RS04535
uniprot id: K4LDP3
names: Similarity
messages: Belongs to the GerABKA family.

1089553:TPH RS05150
gene id: 1089553:TPH_RS05150
uniprot id: K4LGQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

1089553:TPH RS09170
gene id: 1089553:TPH_RS09170
uniprot id: K4LG97
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

1089553:TPH RS13105
gene id: 1089553:TPH_RS13105
uniprot id: K4LXZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

1089553:TPH RS08560
gene id: 1089553:TPH_RS08560
uniprot id: K4LIN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

1089553:TPH RS05520
gene id: 1089553:TPH_RS05520
uniprot id: K4LHB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Cell membrane
messages: Membrane
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

1089553:TPH RS00085
gene id: 1089553:TPH_RS00085
uniprot id: K4LBL4
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1089553:TPH RS00750
gene id: 1089553:TPH_RS00750
uniprot id: K4LCD3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1089553:TPH RS13800
gene id: 1089553:TPH_RS13800
uniprot id: K4LLH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1089553:TPH RS04295
gene id: 1089553:TPH_RS04295
uniprot id: K4LDK5
names: Similarity
messages: Belongs to the glutamate synthase family.

1089553:TPH RS12405
gene id: 1089553:TPH_RS12405
uniprot id: K4LI44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS00080
gene id: 1089553:TPH_RS00080
uniprot id: K4LE83
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1089553:TPH RS11325
gene id: 1089553:TPH_RS11325
uniprot id: K4LWV6
names: Similarity
messages: Belongs to the pyruvoyl-dependent arginine decarboxylase family.

1089553:TPH RS04505
gene id: 1089553:TPH_RS04505
uniprot id: K4LGN1
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: This protein is a Fe-Mo-cofactor biosynthetic component.

1089553:TPH RS12725
gene id: 1089553:TPH_RS12725
uniprot id: K4LL78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1089553:TPH RS05205
gene id: 1089553:TPH_RS05205
uniprot id: K4LEI3
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1089553:TPH RS04525
gene id: 1089553:TPH_RS04525
uniprot id: K4LSU3
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

1089553:TPH RS03265
gene id: 1089553:TPH_RS03265
uniprot id: K4LS18
names: Subcellular Location Annotation
messages: Cytoplasm

1089553:TPH RS13430
gene id: 1089553:TPH_RS13430
uniprot id: K4LLP1
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

1089553:TPH RS00350
gene id: 1089553:TPH_RS00350
uniprot id: K4LE32
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

1089553:TPH RS03080
gene id: 1089553:TPH_RS03080
uniprot id: K4LD29
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

1089553:TPH RS06865
gene id: 1089553:TPH_RS06865
uniprot id: K4LEX3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1089553:TPH RS13200
gene id: 1089553:TPH_RS13200
uniprot id: K4LIZ3
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.

1089553:TPH RS04685
gene id: 1089553:TPH_RS04685
uniprot id: K4LSX7
names: Similarity
names: Subunit
messages: Belongs to the MtrB family.
messages: Oligomer of 11 identical subunits arranged in doughnut-like structure.

1089553:TPH RS05050
gene id: 1089553:TPH_RS05050
uniprot id: K4LT48
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1089553:TPH RS04680
gene id: 1089553:TPH_RS04680
uniprot id: K4LE69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Cytoplasm
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.

1089553:TPH RS05435
gene id: 1089553:TPH_RS05435
uniprot id: K4LER3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS13770
gene id: 1089553:TPH_RS13770
uniprot id: K4LIW8
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1089553:TPH RS05010
gene id: 1089553:TPH_RS05010
uniprot id: K4LDW2
names: Similarity
messages: Belongs to the UPF0236 family.

1089553:TPH RS02140
gene id: 1089553:TPH_RS02140
uniprot id: K4LEZ7
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

1089553:TPH RS02275
gene id: 1089553:TPH_RS02275
uniprot id: K4LFB9
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

1089553:TPH RS12915
gene id: 1089553:TPH_RS12915
uniprot id: K4LLH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1089553:TPH RS05175
gene id: 1089553:TPH_RS05175
uniprot id: K4LGR5
names: Similarity
messages: Belongs to the UPF0102 family.

1089553:TPH RS01915
gene id: 1089553:TPH_RS01915
uniprot id: K4LCW8
names: Similarity
messages: Belongs to the class-I fumarase family.

1089553:TPH RS10215
gene id: 1089553:TPH_RS10215
uniprot id: K4LW73
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS05910
gene id: 1089553:TPH_RS05910
uniprot id: K4LHH4
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

1089553:TPH RS04005
gene id: 1089553:TPH_RS04005
uniprot id: K4LDV1
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1089553:TPH RS10195
gene id: 1089553:TPH_RS10195
uniprot id: K4LH78
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1089553:TPH RS05035
gene id: 1089553:TPH_RS05035
uniprot id: K4LDW8
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

1089553:TPH RS09230
gene id: 1089553:TPH_RS09230
uniprot id: K4LVL2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS11270
gene id: 1089553:TPH_RS11270
uniprot id: K4LHU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1089553:TPH RS07240
gene id: 1089553:TPH_RS07240
uniprot id: K4LHW5
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1089553:TPH RS02680
gene id: 1089553:TPH_RS02680
uniprot id: K4LDB2
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

1089553:TPH RS06215
gene id: 1089553:TPH_RS06215
uniprot id: K4LF33
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

1089553:TPH RS05495
gene id: 1089553:TPH_RS05495
uniprot id: K4LHA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

1089553:TPH RS04405
gene id: 1089553:TPH_RS04405
uniprot id: K4LE12
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

1089553:TPH RS06730
gene id: 1089553:TPH_RS06730
uniprot id: K4LFC5
names: Similarity
messages: Belongs to the UPF0166 family.

1089553:TPH RS10485
gene id: 1089553:TPH_RS10485
uniprot id: K4LK50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

1089553:TPH RS05070
gene id: 1089553:TPH_RS05070
uniprot id: K4LGN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1089553:TPH RS10090
gene id: 1089553:TPH_RS10090
uniprot id: K4LJJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1089553:TPH RS06655
gene id: 1089553:TPH_RS06655
uniprot id: K4LFB3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1089553:TPH RS04195
gene id: 1089553:TPH_RS04195
uniprot id: K4LDI6
names: Function
messages: May be involved in the biosynthesis of molybdopterin.

1089553:TPH RS02100
gene id: 1089553:TPH_RS02100
uniprot id: K4LRD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0316 family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS09250
gene id: 1089553:TPH_RS09250
uniprot id: K4LGR0
names: Caution
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS08320
gene id: 1089553:TPH_RS08320
uniprot id: K4LIJ0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS10410
gene id: 1089553:TPH_RS10410
uniprot id: K4LWD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

1089553:TPH RS08325
gene id: 1089553:TPH_RS08325
uniprot id: K4LGA3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1089553:TPH RS05895
gene id: 1089553:TPH_RS05895
uniprot id: K4LH55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

1089553:TPH RS08980
gene id: 1089553:TPH_RS08980
uniprot id: K4LJ63
names: Similarity
messages: Belongs to the transglycosylase Slt family.

1089553:TPH RS10155
gene id: 1089553:TPH_RS10155
uniprot id: K4LJV6
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.
messages: Cytoplasm

1089553:TPH RS09850
gene id: 1089553:TPH_RS09850
uniprot id: K4LGP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1089553:TPH RS02450
gene id: 1089553:TPH_RS02450
uniprot id: K4LRK5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1089553:TPH RS05745
gene id: 1089553:TPH_RS05745
uniprot id: K4LTJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

1089553:TPH RS09260
gene id: 1089553:TPH_RS09260
uniprot id: K4LJC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS06235
gene id: 1089553:TPH_RS06235
uniprot id: K4LHB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1089553:TPH RS06645
gene id: 1089553:TPH_RS06645
uniprot id: K4LHV0
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

1089553:TPH RS09005
gene id: 1089553:TPH_RS09005
uniprot id: K4LJ67
names: Similarity
messages: Belongs to the CapA family.

1089553:TPH RS13455
gene id: 1089553:TPH_RS13455
uniprot id: K4LY64
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1089553:TPH RS11025
gene id: 1089553:TPH_RS11025
uniprot id: K4LWP4
names: Similarity
names: Subunit
messages: Belongs to the FliD family.
messages: Homopentamer.

1089553:TPH RS06510
gene id: 1089553:TPH_RS06510
uniprot id: K4LF90
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1089553:TPH RS09540
gene id: 1089553:TPH_RS09540
uniprot id: K4LJH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS02415
gene id: 1089553:TPH_RS02415
uniprot id: K4LF45
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1089553:TPH RS12690
gene id: 1089553:TPH_RS12690
uniprot id: K4LIK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1089553:TPH RS04640
gene id: 1089553:TPH_RS04640
uniprot id: K4LDQ6
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1089553:TPH RS03735
gene id: 1089553:TPH_RS03735
uniprot id: K4LDB5
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

1089553:TPH RS03610
gene id: 1089553:TPH_RS03610
uniprot id: K4LDA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

1089553:TPH RS04285
gene id: 1089553:TPH_RS04285
uniprot id: K4LSN4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

1089553:TPH RS03510
gene id: 1089553:TPH_RS03510
uniprot id: K4LD86
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutB family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

1089553:TPH RS13160
gene id: 1089553:TPH_RS13160
uniprot id: K4LLK6
names: Similarity
messages: Belongs to the TrpC family.

1089553:TPH RS00360
gene id: 1089553:TPH_RS00360
uniprot id: K4LQG6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

1089553:TPH RS05805
gene id: 1089553:TPH_RS05805
uniprot id: K4LTK9
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1089553:TPH RS05705
gene id: 1089553:TPH_RS05705
uniprot id: K4LEA2
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

1089553:TPH RS13525
gene id: 1089553:TPH_RS13525
uniprot id: K4LLQ7
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.

1089553:TPH RS02600
gene id: 1089553:TPH_RS02600
uniprot id: K4LCT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1089553:TPH RS09835
gene id: 1089553:TPH_RS09835
uniprot id: K4LH08
names: Similarity
messages: Belongs to the UPF0749 family.

1089553:TPH RS13940
gene id: 1089553:TPH_RS13940
uniprot id: K4LJ02
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1089553:TPH RS04900
gene id: 1089553:TPH_RS04900
uniprot id: K4LT24
names: Similarity
messages: Belongs to the pyruvoyl-dependent arginine decarboxylase family.

1089553:TPH RS10100
gene id: 1089553:TPH_RS10100
uniprot id: K4LW47
names: Similarity
messages: Belongs to the AOR/FOR family.

1089553:TPH RS02705
gene id: 1089553:TPH_RS02705
uniprot id: K4LFD4
names: Similarity
messages: Belongs to the MotB family.

1089553:TPH RS10705
gene id: 1089553:TPH_RS10705
uniprot id: K4LHK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1089553:TPH RS04240
gene id: 1089553:TPH_RS04240
uniprot id: K4LGH2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1089553:TPH RS03425
gene id: 1089553:TPH_RS03425
uniprot id: K4LD76
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

1089553:TPH RS00805
gene id: 1089553:TPH_RS00805
uniprot id: K4LCE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1089553:TPH RS05915
gene id: 1089553:TPH_RS05915
uniprot id: K4LEE0
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

1089553:TPH RS08225
gene id: 1089553:TPH_RS08225
uniprot id: K4LG88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1089553:TPH RS04320
gene id: 1089553:TPH_RS04320
uniprot id: K4LDK8
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS11800
gene id: 1089553:TPH_RS11800
uniprot id: K4LX54
names: Similarity
messages: Belongs to the EamA transporter family.

1089553:TPH RS14015
gene id: 1089553:TPH_RS14015
uniprot id: K4LLL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1089553:TPH RS09015
gene id: 1089553:TPH_RS09015
uniprot id: K4LIW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1089553:TPH RS01995
gene id: 1089553:TPH_RS01995
uniprot id: K4LF71
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS08625
gene id: 1089553:TPH_RS08625
uniprot id: K4LIZ8
names: Similarity
messages: Belongs to the thioredoxin family.

1089553:TPH RS05260
gene id: 1089553:TPH_RS05260
uniprot id: K4LEM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gas vesicle GvpF/GvpL family.
messages: Gas vesicle
messages: Vesicle

1089553:TPH RS10150
gene id: 1089553:TPH_RS10150
uniprot id: K4LW59
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

1089553:TPH RS05315
gene id: 1089553:TPH_RS05315
uniprot id: K4LTD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gas vesicle GvpF/GvpL family.
messages: Gas vesicle
messages: Vesicle

1089553:TPH RS06710
gene id: 1089553:TPH_RS06710
uniprot id: K4LU48
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

1089553:TPH RS01690
gene id: 1089553:TPH_RS01690
uniprot id: K4LY64
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1089553:TPH RS02385
gene id: 1089553:TPH_RS02385
uniprot id: K4LCP6
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

1089553:TPH RS10840
gene id: 1089553:TPH_RS10840
uniprot id: K4LK98
names: Similarity
messages: Belongs to the manganese catalase family.

1089553:TPH RS12545
gene id: 1089553:TPH_RS12545
uniprot id: K4LL44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS09865
gene id: 1089553:TPH_RS09865
uniprot id: K4LVZ1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADH to yield (R)-2,3-dihydroxy-isovalerate.

1089553:TPH RS10960
gene id: 1089553:TPH_RS10960
uniprot id: K4LY64
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1089553:TPH RS08310
gene id: 1089553:TPH_RS08310
uniprot id: K4LIU0
names: Similarity
messages: Belongs to the GSP E family.

1089553:TPH RS09195
gene id: 1089553:TPH_RS09195
uniprot id: K4LGA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1089553:TPH RS13805
gene id: 1089553:TPH_RS13805
uniprot id: K4LJ91
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

1089553:TPH RS04500
gene id: 1089553:TPH_RS04500
uniprot id: K4LE29
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1089553:TPH RS14075
gene id: 1089553:TPH_RS14075
uniprot id: K4LM07
names: Function
names: Similarity
messages: Belongs to the peptidase S51 family.
messages: Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.

1089553:TPH RS13705
gene id: 1089553:TPH_RS13705
uniprot id: K4LJ72
names: Similarity
messages: Belongs to the AOR/FOR family.

1089553:TPH RS04235
gene id: 1089553:TPH_RS04235
uniprot id: K4LSM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1089553:TPH RS07180
gene id: 1089553:TPH_RS07180
uniprot id: K4LI55
names: Similarity
messages: Belongs to the YicC/YloC family.

1089553:TPH RS12100
gene id: 1089553:TPH_RS12100
uniprot id: K4LIA0
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

1089553:TPH RS10455
gene id: 1089553:TPH_RS10455
uniprot id: K4LWE0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1089553:TPH RS08865
gene id: 1089553:TPH_RS08865
uniprot id: K4LGJ1
names: Similarity
messages: Belongs to the UPF0045 family.

1089553:TPH RS10015
gene id: 1089553:TPH_RS10015
uniprot id: K4LH41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS13490
gene id: 1089553:TPH_RS13490
uniprot id: K4LIR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CotF family.
messages: Spore coat

1089553:TPH RS01795
gene id: 1089553:TPH_RS01795
uniprot id: K4LR75
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1089553:TPH RS08255
gene id: 1089553:TPH_RS08255
uniprot id: K4LV08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Membrane

1089553:TPH RS02595
gene id: 1089553:TPH_RS02595
uniprot id: K4LFI0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

1089553:TPH RS07775
gene id: 1089553:TPH_RS07775
uniprot id: K4LFX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1089553:TPH RS12390
gene id: 1089553:TPH_RS12390
uniprot id: K4LKS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS10710
gene id: 1089553:TPH_RS10710
uniprot id: K4LWI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

1089553:TPH RS05120
gene id: 1089553:TPH_RS05120
uniprot id: K4LDY1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1089553:TPH RS05635
gene id: 1089553:TPH_RS05635
uniprot id: K4LH18
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

1089553:TPH RS06910
gene id: 1089553:TPH_RS06910
uniprot id: K4LEY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS07995
gene id: 1089553:TPH_RS07995
uniprot id: K4LIE8
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1089553:TPH RS08910
gene id: 1089553:TPH_RS08910
uniprot id: K4LIU6
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1089553:TPH RS03010
gene id: 1089553:TPH_RS03010
uniprot id: K4LFJ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1089553:TPH RS13920
gene id: 1089553:TPH_RS13920
uniprot id: K4LLJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS02300
gene id: 1089553:TPH_RS02300
uniprot id: K4LFC4
names: Similarity
messages: Belongs to the RuBisCO large chain family.

1089553:TPH RS09715
gene id: 1089553:TPH_RS09715
uniprot id: K4LVW4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1089553:TPH RS09100
gene id: 1089553:TPH_RS09100
uniprot id: K4LIY3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1089553:TPH RS04200
gene id: 1089553:TPH_RS04200
uniprot id: K4LG54
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1089553:TPH RS03365
gene id: 1089553:TPH_RS03365
uniprot id: K4LS35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1089553:TPH RS10420
gene id: 1089553:TPH_RS10420
uniprot id: K4LH44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

1089553:TPH RS01725
gene id: 1089553:TPH_RS01725
uniprot id: K4LCC5
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

1089553:TPH RS10580
gene id: 1089553:TPH_RS10580
uniprot id: K4LWG1
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS10975
gene id: 1089553:TPH_RS10975
uniprot id: K4LWN4
names: Similarity
messages: Belongs to the EamA transporter family.

1089553:TPH RS02930
gene id: 1089553:TPH_RS02930
uniprot id: K4LFI1
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.

1089553:TPH RS08515
gene id: 1089553:TPH_RS08515
uniprot id: K4LGD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS02830
gene id: 1089553:TPH_RS02830
uniprot id: K4LFG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

1089553:TPH RS05795
gene id: 1089553:TPH_RS05795
uniprot id: K4LH39
names: Similarity
messages: Belongs to the AAA ATPase family.
messages: In the C-terminal section; belongs to the peptidase M41 family.

1089553:TPH RS07780
gene id: 1089553:TPH_RS07780
uniprot id: K4LUR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

1089553:TPH RS10600
gene id: 1089553:TPH_RS10600
uniprot id: K4LHJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1089553:TPH RS05325
gene id: 1089553:TPH_RS05325
uniprot id: K4LE42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gas vesicle GvpA family.
messages: Gas vesicle shell
messages: Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. During planktonic growth they allow positioning of the organism at a favorable depth for light or nutrient acquisition. GvpA forms the protein shell.
messages: The gas vesicle shell is 2 nm thick and consists of a single layer of this protein. It forms helical ribs nearly perpendicular to the long axis of the vesicle.

1089553:TPH RS08020
gene id: 1089553:TPH_RS08020
uniprot id: K4LIF2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

1089553:TPH RS13585
gene id: 1089553:TPH_RS13585
uniprot id: K4LY91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1089553:TPH RS01960
gene id: 1089553:TPH_RS01960
uniprot id: K4LEW1
names: Similarity
messages: Belongs to the ycf81 family.

1089553:TPH RS08575
gene id: 1089553:TPH_RS08575
uniprot id: K4LIY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1089553:TPH RS06700
gene id: 1089553:TPH_RS06700
uniprot id: K4LHK3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1089553:TPH RS07110
gene id: 1089553:TPH_RS07110
uniprot id: K4LF17
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1089553:TPH RS06225
gene id: 1089553:TPH_RS06225
uniprot id: K4LHN0
names: Similarity
messages: Belongs to the PemK/MazF family.

1089553:TPH RS05870
gene id: 1089553:TPH_RS05870
uniprot id: K4LH52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

1089553:TPH RS04515
gene id: 1089553:TPH_RS04515
uniprot id: K4LGC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1089553:TPH RS14435
gene id: 1089553:TPH_RS14435
uniprot id: K4LJ98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

1089553:TPH RS02700
gene id: 1089553:TPH_RS02700
uniprot id: K4LCX1
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1089553:TPH RS10525
gene id: 1089553:TPH_RS10525
uniprot id: K4LHI0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1089553:TPH RS01270
gene id: 1089553:TPH_RS01270
uniprot id: K4LEH9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

1089553:TPH RS00225
gene id: 1089553:TPH_RS00225
uniprot id: K4LBP5
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS07235
gene id: 1089553:TPH_RS07235
uniprot id: K4LF44
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

1089553:TPH RS14025
gene id: 1089553:TPH_RS14025
uniprot id: K4LLZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1089553:TPH RS08775
gene id: 1089553:TPH_RS08775
uniprot id: K4LJ27
names: Similarity
messages: Belongs to the UPF0236 family.

1089553:TPH RS04895
gene id: 1089553:TPH_RS04895
uniprot id: K4LEB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1089553:TPH RS14370
gene id: 1089553:TPH_RS14370
uniprot id: K4LJ85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1089553:TPH RS14080
gene id: 1089553:TPH_RS14080
uniprot id: K4LJ33
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS11255
gene id: 1089553:TPH_RS11255
uniprot id: K4LKH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family.
messages: Membrane

1089553:TPH RS06015
gene id: 1089553:TPH_RS06015
uniprot id: K4LEG2
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

1089553:TPH RS04355
gene id: 1089553:TPH_RS04355
uniprot id: K4LE03
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

1089553:TPH RS12700
gene id: 1089553:TPH_RS12700
uniprot id: K4LL72
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1089553:TPH RS13100
gene id: 1089553:TPH_RS13100
uniprot id: K4LIX6
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

1089553:TPH RS09825
gene id: 1089553:TPH_RS09825
uniprot id: K4LGN3
names: Similarity
messages: Belongs to the UPF0749 family.

1089553:TPH RS07830
gene id: 1089553:TPH_RS07830
uniprot id: K4LUU1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

1089553:TPH RS07165
gene id: 1089553:TPH_RS07165
uniprot id: K4LHU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1089553:TPH RS14385
gene id: 1089553:TPH_RS14385
uniprot id: K4LLT4
names: Similarity
messages: Belongs to the NAD synthetase family.

1089553:TPH RS06620
gene id: 1089553:TPH_RS06620
uniprot id: K4LES1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS00585
gene id: 1089553:TPH_RS00585
uniprot id: K4LBU5
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS10565
gene id: 1089553:TPH_RS10565
uniprot id: K4LH69
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1089553:TPH RS08405
gene id: 1089553:TPH_RS08405
uniprot id: K4LFV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

1089553:TPH RS11240
gene id: 1089553:TPH_RS11240
uniprot id: K4LK55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

1089553:TPH RS12800
gene id: 1089553:TPH_RS12800
uniprot id: K4LL91
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1089553:TPH RS12000
gene id: 1089553:TPH_RS12000
uniprot id: K4LX95
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

1089553:TPH RS04265
gene id: 1089553:TPH_RS04265
uniprot id: K4LGH5
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1089553:TPH RS10365
gene id: 1089553:TPH_RS10365
uniprot id: K4LWC2
names: Similarity
messages: Belongs to the manganese catalase family.

1089553:TPH RS12615
gene id: 1089553:TPH_RS12615
uniprot id: K4LII9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1089553:TPH RS02000
gene id: 1089553:TPH_RS02000
uniprot id: K4LCI6
names: Similarity
messages: Belongs to the peptidase S49 family.

1089553:TPH RS13305
gene id: 1089553:TPH_RS13305
uniprot id: K4LJ10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1089553:TPH RS10070
gene id: 1089553:TPH_RS10070
uniprot id: K4LW41
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

1089553:TPH RS02460
gene id: 1089553:TPH_RS02460
uniprot id: K4LCR1
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

1089553:TPH RS13195
gene id: 1089553:TPH_RS13195
uniprot id: K4LLA0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1089553:TPH RS05005
gene id: 1089553:TPH_RS05005
uniprot id: K4LGY0
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

1089553:TPH RS09860
gene id: 1089553:TPH_RS09860
uniprot id: K4LH12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homodimer.

1089553:TPH RS10000
gene id: 1089553:TPH_RS10000
uniprot id: K4LJS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS02790
gene id: 1089553:TPH_RS02790
uniprot id: K4LFQ9
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS02375
gene id: 1089553:TPH_RS02375
uniprot id: K4LRI9
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

1089553:TPH RS09935
gene id: 1089553:TPH_RS09935
uniprot id: K4LJ27
names: Similarity
messages: Belongs to the UPF0236 family.

1089553:TPH RS11290
gene id: 1089553:TPH_RS11290
uniprot id: K4LK63
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1089553:TPH RS12910
gene id: 1089553:TPH_RS12910
uniprot id: K4LXW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1089553:TPH RS10075
gene id: 1089553:TPH_RS10075
uniprot id: K4LJU0
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

1089553:TPH RS13630
gene id: 1089553:TPH_RS13630
uniprot id: K4LJ60
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

1089553:TPH RS05375
gene id: 1089553:TPH_RS05375
uniprot id: K4LE50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1089553:TPH RS13285
gene id: 1089553:TPH_RS13285
uniprot id: K4LJ05
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

1089553:TPH RS10360
gene id: 1089553:TPH_RS10360
uniprot id: K4LHE8
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1089553:TPH RS11135
gene id: 1089553:TPH_RS11135
uniprot id: K4LK40
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

1089553:TPH RS09310
gene id: 1089553:TPH_RS09310
uniprot id: K4LJD0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1089553:TPH RS01365
gene id: 1089553:TPH_RS01365
uniprot id: K4LC54
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS12750
gene id: 1089553:TPH_RS12750
uniprot id: K4LL83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1089553:TPH RS11885
gene id: 1089553:TPH_RS11885
uniprot id: K4LKS1
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS05450
gene id: 1089553:TPH_RS05450
uniprot id: K4LE63
names: Similarity
messages: Belongs to the FlgD family.

1089553:TPH RS00165
gene id: 1089553:TPH_RS00165
uniprot id: K4LQE3
names: Similarity
messages: Belongs to the ParB family.

1089553:TPH RS04420
gene id: 1089553:TPH_RS04420
uniprot id: K4LDM5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

1089553:TPH RS03515
gene id: 1089553:TPH_RS03515
uniprot id: K4LFR9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutC family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

1089553:TPH RS03395
gene id: 1089553:TPH_RS03395
uniprot id: K4LG09
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

1089553:TPH RS10915
gene id: 1089553:TPH_RS10915
uniprot id: K4LWM3
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

1089553:TPH RS10095
gene id: 1089553:TPH_RS10095
uniprot id: K4LH56
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS06745
gene id: 1089553:TPH_RS06745
uniprot id: K4LEU8
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

1089553:TPH RS06770
gene id: 1089553:TPH_RS06770
uniprot id: K4LEV3
names: Similarity
messages: Belongs to the UPF0047 family.

1089553:TPH RS08995
gene id: 1089553:TPH_RS08995
uniprot id: K4LGL5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1089553:TPH RS13155
gene id: 1089553:TPH_RS13155
uniprot id: K4LY06
names: Similarity
messages: Belongs to the TrpF family.

1089553:TPH RS00145
gene id: 1089553:TPH_RS00145
uniprot id: K4LE98
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1089553:TPH RS12925
gene id: 1089553:TPH_RS12925
uniprot id: K4LL64
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1089553:TPH RS05470
gene id: 1089553:TPH_RS05470
uniprot id: K4LHA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

1089553:TPH RS10160
gene id: 1089553:TPH_RS10160
uniprot id: K4LGV7
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS13950
gene id: 1089553:TPH_RS13950
uniprot id: K4LYH1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1089553:TPH RS13545
gene id: 1089553:TPH_RS13545
uniprot id: K4LLR2
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1089553:TPH RS08555
gene id: 1089553:TPH_RS08555
uniprot id: K4LFY4
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1089553:TPH RS06935
gene id: 1089553:TPH_RS06935
uniprot id: K4LEY9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1089553:TPH RS00175
gene id: 1089553:TPH_RS00175
uniprot id: K4LBN6
names: Function
names: Similarity
messages: Belongs to the LarC family.
messages: Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.

1089553:TPH RS05645
gene id: 1089553:TPH_RS05645
uniprot id: K4LTI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1089553:TPH RS12610
gene id: 1089553:TPH_RS12610
uniprot id: K4LKW8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

1089553:TPH RS07950
gene id: 1089553:TPH_RS07950
uniprot id: K4LG44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS08780
gene id: 1089553:TPH_RS08780
uniprot id: K4LG20
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

1089553:TPH RS01055
gene id: 1089553:TPH_RS01055
uniprot id: K4LEP6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1089553:TPH RS13965
gene id: 1089553:TPH_RS13965
uniprot id: K4LLK5
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.
messages: Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.

1089553:TPH RS13960
gene id: 1089553:TPH_RS13960
uniprot id: K4LJ07
names: Similarity
messages: Belongs to the peptidase S8 family.

1089553:TPH RS13165
gene id: 1089553:TPH_RS13165
uniprot id: K4LIL8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS03035
gene id: 1089553:TPH_RS03035
uniprot id: K4LFJ5
names: Similarity
messages: Belongs to the transpeptidase family.

1089553:TPH RS00670
gene id: 1089553:TPH_RS00670
uniprot id: K4LCC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1089553:TPH RS13510
gene id: 1089553:TPH_RS13510
uniprot id: K4LLD6
names: Similarity
messages: Belongs to the DtxR/MntR family.

1089553:TPH RS13220
gene id: 1089553:TPH_RS13220
uniprot id: K4LIZ7
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1089553:TPH RS08100
gene id: 1089553:TPH_RS08100
uniprot id: K4LG69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

1089553:TPH RS08650
gene id: 1089553:TPH_RS08650
uniprot id: K4LV90
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

1089553:TPH RS07680
gene id: 1089553:TPH_RS07680
uniprot id: K4LIF1
names: Cofactor
messages: Binds 4 [4Fe-4S] clusters per subunit.

1089553:TPH RS09330
gene id: 1089553:TPH_RS09330
uniprot id: K4LVN4
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1089553:TPH RS08920
gene id: 1089553:TPH_RS08920
uniprot id: K4LVF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS08305
gene id: 1089553:TPH_RS08305
uniprot id: K4LV18
names: Similarity
messages: Belongs to the GSP E family.

1089553:TPH RS04700
gene id: 1089553:TPH_RS04700
uniprot id: K4LE75
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

1089553:TPH RS00780
gene id: 1089553:TPH_RS00780
uniprot id: K4LCD8
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1089553:TPH RS12685
gene id: 1089553:TPH_RS12685
uniprot id: K4LKY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1089553:TPH RS12090
gene id: 1089553:TPH_RS12090
uniprot id: K4LHX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1089553:TPH RS06685
gene id: 1089553:TPH_RS06685
uniprot id: K4LU43
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1089553:TPH RS07215
gene id: 1089553:TPH_RS07215
uniprot id: K4LHW0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

1089553:TPH RS03580
gene id: 1089553:TPH_RS03580
uniprot id: K4LG38
names: Similarity
messages: Belongs to the AOR/FOR family.

1089553:TPH RS06775
gene id: 1089553:TPH_RS06775
uniprot id: K4LHL9
names: Similarity
messages: Belongs to the UPF0047 family.

1089553:TPH RS10545
gene id: 1089553:TPH_RS10545
uniprot id: K4LJW4
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS12670
gene id: 1089553:TPH_RS12670
uniprot id: K4LXM1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS06860
gene id: 1089553:TPH_RS06860
uniprot id: K4LHZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1089553:TPH RS11755
gene id: 1089553:TPH_RS11755
uniprot id: K4LHR9
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS12830
gene id: 1089553:TPH_RS12830
uniprot id: K4LID8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1089553:TPH RS08615
gene id: 1089553:TPH_RS08615
uniprot id: K4LGE7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1089553:TPH RS11705
gene id: 1089553:TPH_RS11705
uniprot id: K4LHR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS03375
gene id: 1089553:TPH_RS03375
uniprot id: K4LD68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1089553:TPH RS04490
gene id: 1089553:TPH_RS04490
uniprot id: K4LDN6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1089553:TPH RS14270
gene id: 1089553:TPH_RS14270
uniprot id: K4LM40
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

1089553:TPH RS01040
gene id: 1089553:TPH_RS01040
uniprot id: K4LED9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

1089553:TPH RS07170
gene id: 1089553:TPH_RS07170
uniprot id: K4LFJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1089553:TPH RS01190
gene id: 1089553:TPH_RS01190
uniprot id: K4LCK2
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS07820
gene id: 1089553:TPH_RS07820
uniprot id: K4LIB2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1089553:TPH RS14050
gene id: 1089553:TPH_RS14050
uniprot id: K4LM03
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

1089553:TPH RS13755
gene id: 1089553:TPH_RS13755
uniprot id: K4LJ82
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1089553:TPH RS05270
gene id: 1089553:TPH_RS05270
uniprot id: K4LH62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gas vesicle GvpK family.
messages: Gas vesicle
messages: Vesicle

1089553:TPH RS07175
gene id: 1089553:TPH_RS07175
uniprot id: K4LUE8
names: Similarity
messages: Belongs to the RemA family.

1089553:TPH RS13695
gene id: 1089553:TPH_RS13695
uniprot id: K4LIV3
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

1089553:TPH RS10850
gene id: 1089553:TPH_RS10850
uniprot id: K4LHA9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1089553:TPH RS04345
gene id: 1089553:TPH_RS04345
uniprot id: K4LDL3
names: Similarity
messages: Belongs to the P(II) protein family.

1089553:TPH RS05130
gene id: 1089553:TPH_RS05130
uniprot id: K4LEG8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

1089553:TPH RS02370
gene id: 1089553:TPH_RS02370
uniprot id: K4LD42
names: Similarity
messages: Belongs to the peptidase S16 family.

1089553:TPH RS04080
gene id: 1089553:TPH_RS04080
uniprot id: K4LDW4
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

1089553:TPH RS00770
gene id: 1089553:TPH_RS00770
uniprot id: K4LBX1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1089553:TPH RS12085
gene id: 1089553:TPH_RS12085
uniprot id: K4LKW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1089553:TPH RS00580
gene id: 1089553:TPH_RS00580
uniprot id: K4LEH1
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS14345
gene id: 1089553:TPH_RS14345
uniprot id: K4LJ80
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS07220
gene id: 1089553:TPH_RS07220
uniprot id: K4LFK7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

1089553:TPH RS14235
gene id: 1089553:TPH_RS14235
uniprot id: K4LJH5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS02355
gene id: 1089553:TPH_RS02355
uniprot id: K4LFD3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1089553:TPH RS06525
gene id: 1089553:TPH_RS06525
uniprot id: K4LEQ5
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

1089553:TPH RS10460
gene id: 1089553:TPH_RS10460
uniprot id: K4LK48
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1089553:TPH RS12745
gene id: 1089553:TPH_RS12745
uniprot id: K4LXN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1089553:TPH RS00220
gene id: 1089553:TPH_RS00220
uniprot id: K4LEB7
names: Similarity
messages: Belongs to the leucine-binding protein family.

1089553:TPH RS01805
gene id: 1089553:TPH_RS01805
uniprot id: K4LCE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1089553:TPH RS07155
gene id: 1089553:TPH_RS07155
uniprot id: K4LI51
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS06550
gene id: 1089553:TPH_RS06550
uniprot id: K4LER0
names: Similarity
messages: Belongs to the peptidase S58 family.

1089553:TPH RS12855
gene id: 1089553:TPH_RS12855
uniprot id: K4LIE3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1089553:TPH RS03860
gene id: 1089553:TPH_RS03860
uniprot id: K4LDS6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.
messages: Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.

1089553:TPH RS12805
gene id: 1089553:TPH_RS12805
uniprot id: K4LID1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1089553:TPH RS04785
gene id: 1089553:TPH_RS04785
uniprot id: K4LGU0
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

1089553:TPH RS06280
gene id: 1089553:TPH_RS06280
uniprot id: K4LEK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

1089553:TPH RS00850
gene id: 1089553:TPH_RS00850
uniprot id: K4LBX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1089553:TPH RS13045
gene id: 1089553:TPH_RS13045
uniprot id: K4LIW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit C family.
messages: Membrane

1089553:TPH RS08850
gene id: 1089553:TPH_RS08850
uniprot id: K4LJ40
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

1089553:TPH RS06955
gene id: 1089553:TPH_RS06955
uniprot id: K4LI14
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1089553:TPH RS08435
gene id: 1089553:TPH_RS08435
uniprot id: K4LIK9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1089553:TPH RS11045
gene id: 1089553:TPH_RS11045
uniprot id: K4LWP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

1089553:TPH RS01150
gene id: 1089553:TPH_RS01150
uniprot id: K4LER4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1089553:TPH RS14265
gene id: 1089553:TPH_RS14265
uniprot id: K4LYN6
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1089553:TPH RS04225
gene id: 1089553:TPH_RS04225
uniprot id: K4LG59
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1089553:TPH RS08340
gene id: 1089553:TPH_RS08340
uniprot id: K4LIJ4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

1089553:TPH RS12705
gene id: 1089553:TPH_RS12705
uniprot id: K4LIA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1089553:TPH RS06945
gene id: 1089553:TPH_RS06945
uniprot id: K4LFG4
names: Similarity
messages: Belongs to the histone deacetylase family.

1089553:TPH RS04585
gene id: 1089553:TPH_RS04585
uniprot id: K4LGP8
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

1089553:TPH RS11810
gene id: 1089553:TPH_RS11810
uniprot id: K4LHS3
names: Subcellular Location Annotation
messages: Membrane

1089553:TPH RS00090
gene id: 1089553:TPH_RS00090
uniprot id: K4LDZ3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1089553:TPH RS02920
gene id: 1089553:TPH_RS02920
uniprot id: K4LFT2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1089553:TPH RS02975
gene id: 1089553:TPH_RS02975
uniprot id: K4LFU1
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

1089553:TPH RS08125
gene id: 1089553:TPH_RS08125
uniprot id: K4LG72
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1089553:TPH RS05670
gene id: 1089553:TPH_RS05670
uniprot id: K4LTI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1089553:TPH RS05865
gene id: 1089553:TPH_RS05865
uniprot id: K4LED1
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

1089553:TPH RS04340
gene id: 1089553:TPH_RS04340
uniprot id: K4LGJ4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-100 inactivates the nitrogenase reductase and regulates nitrogenase activity.

1089553:TPH RS01490
gene id: 1089553:TPH_RS01490
uniprot id: K4LC80
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1089553:TPH RS06395
gene id: 1089553:TPH_RS06395
uniprot id: K4LTY1
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.