108098:HAdVB2 gp03
gene id: 108098:HAdVB2_gp03
uniprot id: Q5UW19
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenoviridae hexon-interlacing protein family.
messages: Expressed in the intermediate phase of the viral replicative cycle.
messages: Homotrimer. Interacts with hexon protein; this interaction tethers the hexons together. Self-interacts with adjacent proteins. Interacts with kinesin light chain KLC1; this interaction leads to capsid disruption at the nuclear pore complex during virus entry into host cell.
messages: Host nucleus
messages: Structural component of the virion that acts as a cement protein on the capsid exterior and forms triskelion structures consisting of three molecules that stabilize three hexon trimers at the center of each icosahedral facet and fixes the peripentonal hexons. Dispensable for assembly. During virus entry, recruits the anterograde motor kinesin-1 to the capsid docked at the nuclear pore complex thereby subjecting the docked capsid to a pulling force. The resulting tension leads to capsid disruption, dispersion of capsid fragments toward cell periphery and eventually viral DNA entry into the host nucleus.
messages: This protein is only encoded by mastadenoviruses, and may therefore play a role in mammals tropism.
messages: Three N-terminal domains of hexon-interlacing protein form triskelions between hexon capsomers.
messages: Virion

108098:HAdVB2 gp11
gene id: 108098:HAdVB2_gp11
uniprot id: Q5UW06
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenoviridae E2A DNA-binding protein family.
messages: Homomultimerizes on viral ssDNA bound to pTP. Forms a initiation complex with viral polymerase, pTP and hosts NFIA and POU2F1/OCT1. Interacts with host SRCAP.
messages: Host nucleus
messages: Plays a role in the elongation phase of viral strand displacement replication by unwinding the template in an ATP-independent fashion, employing its capacity to form multimers. Also enhances the rate of initiation. Released from template upon second strand synthesis. Assembles in complex with viral pTP, viral pol, host NFIA and host POU2F1/OCT1 on viral origin of replication. Covers the whole ssDNA genome during synthesis. The complementary strand synthesis induces its relese from DNA template. May inhibit cellular transcription mediated by the interaction between host SRCAP and CBP.
messages: The C-terminal arm bridges DBP molecules together, thereby creating a chain.

108098:HAdVB2 gp06
gene id: 108098:HAdVB2_gp06
uniprot id: Q5UVZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenoviridae fiber family.
messages: Host nucleus
messages: Nucleus
messages: Virion

108098:HAdVB2 gp02
gene id: 108098:HAdVB2_gp02
uniprot id: Q5UW20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenoviridae E1B 55 kDa protein family.
messages: Cytoplasm
messages: Host cytoplasm
messages: Host nucleus
messages: Nucleus
messages: Plays a major role to prevent cellular inhibition of viral genome replication. Assembles an SCF-like E3 ubiquitin ligase complex based on the cellular proteins ELOB, ELOC, CUL5 and RBX1, in cooperation with viral E4orf6. This viral RING-type ligase ubiquitinates cellular substrates and targets them to proteasomal degradation: TP53/p53, LIG4, MRE11-RAD50-NBS1 (MRN) complex, ITGA3, DAXX and BLM. Degradation of host TP53/p53 activity is essential for preventing E1A-induced TP53 accumulation that would otherwise lead to cell apoptosis and growth arrest. E1B-55K also inactivates TP53 transcription-factor activity by binding its transactivation domain. E1B-55K also functions as a SUMO1 E3 ligase for TP53 which causes the latter to be sequestered in promyelocytic leukemia (PML) nuclear bodies thereby contributing to maximal inhibition of TP53 function.

108098:HAdVB1 gp13
gene id: 108098:HAdVB1_gp13
uniprot id: I6LER5
names: Subcellular Location Annotation
messages: Membrane

108098:HAdVB1 gp08
gene id: 108098:HAdVB1_gp08
uniprot id: I6LET2
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
messages: Belongs to the peptidase C5 family.
messages: Cleaves viral precursor proteins (pTP, pIIIa, pVI, pVII, pVIII, and pX) inside newly assembled particles giving rise to mature virions. Protease complexed to its cofactor slides along the viral DNA to specifically locate and cleave the viral precursors. Mature virions have a weakened organization compared to the unmature virions, thereby facilitating subsequent uncoating. Without maturation, the particle lacks infectivity and is unable to uncoat. Late in adenovirus infection, in the cytoplasm, may participate in the cytoskeleton destruction. Cleaves host cell cytoskeletal keratins K7 and K18.
messages: Expressed in the late phase of the viral replicative cycle.
messages: Host nucleus
messages: Interacts with protease cofactor pVI-C; this interaction is necessary for protease activation.
messages: Requires DNA and protease cofactor for maximal activation. Inside nascent virions, becomes partially activated by binding to the viral DNA, allowing it to cleave the cofactor that binds to the protease and fully activates it. Actin, like the viral protease cofactor, seems to act as a cofactor in the cleavage of cytokeratin 18 and of actin itself.
messages: Virion

108098:HAdVB2 gp08
gene id: 108098:HAdVB2_gp08
uniprot id: Q5UW07
uniprot id: Q5UW08
uniprot id: Q5UW09
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
messages: Belongs to the adenoviridae hexon protein family.
messages: Belongs to the adenoviridae protein VI family.
messages: Belongs to the peptidase C5 family.
messages: Cleaves viral precursor proteins (pTP, pIIIa, pVI, pVII, pVIII, and pX) inside newly assembled particles giving rise to mature virions. Protease complexed to its cofactor slides along the viral DNA to specifically locate and cleave the viral precursors. Mature virions have a weakened organization compared to the unmature virions, thereby facilitating subsequent uncoating. Without maturation, the particle lacks infectivity and is unable to uncoat. Late in adenovirus infection, in the cytoplasm, may participate in the cytoskeleton destruction. Cleaves host cell cytoskeletal keratins K7 and K18.
messages: Endosome lysis protein: Structural component of the virion that provides increased stability to the particle shell through its interaction with the core-capsid bridging protein and the hexon-linking protein VIII. Fibers shedding during virus entry into host cell allows the endosome lysis protein to be exposed as a membrane-lytic peptide. Exhibits pH-independent membrane fragmentation activity and probably mediates viral rapid escape from host endosome via organellar membrane lysis. It is not clear if it then remains partially associated with the capsid and involved in the intracellular microtubule-dependent transport of capsid to the nucleus, or if it is lost during endosomal penetration.
messages: Expressed in the late phase of the viral replicative cycle.
messages: Heterodimer with the viral protease; disulfide-linked. Interacts with the viral protease.
messages: Homotrimer. Interacts with the capsid vertex protein; this interaction binds the peripentonal hexons to the neighboring penton base. Interacts with the hexon-linking protein; this interaction tethers the hexons surrounding the penton to those situated in the central plate of the facet. Interacts with the hexon-interlacing protein; this interaction lashes the hexons together. Interacts with host dyneins DYNC1LI1 and DYNC1I2; this interaction might be involved in intracellular microtubule-dependent transport of incoming viral capsid. Interacts with the shutoff protein; this interaction allows folding and formation of hexons trimers. Interacts with pre-protein VI; this interaction probably allows nuclear import of hexon trimers and possibly pre-capsid assembly.
messages: Host cytoplasm
messages: Host nucleus
messages: Interacts (via PPxY motif) with host NEDD4 ubiquitine ligase; this interaction might play a role in virus intracellular transport during entry. Part of a complex composed of the core-capsid bridging protein, the endosome lysis protein VI and the hexon-linking protein VIII; these interactions bridge the virus core to the capsid. Interacts with peripentonal hexons; this interaction stabilizes the capsid by gluing two peripentonal hexons together and joining them with an adjacent group-of-nine hexon.
messages: Interacts with hexon protein; this interaction allows nuclear import of hexon trimers and possibly pre-capsid assembly. Interacts (via C-terminal NLS) with importin alpha/beta.
messages: Interacts with protease cofactor pVI-C; this interaction is necessary for protease activation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Late-budding domains (L domains) are short sequence motifs essential for viral particle release. They can occur individually or in close proximity within structural proteins. They interacts with sorting cellular proteins of the multivesicular body (MVB) pathway. Most of these proteins are class E vacuolar protein sorting factors belonging to ESCRT-I, ESCRT-II or ESCRT-III complexes. Minor capsid protein 6 contains one L domain: a PPXY motif which binds to the WW domains of HECT (homologous to E6-AP C-terminus) E3 ubiquitin ligases, like NEDD4. In adenoviruses, this motif seems to play a role in microtubule-dependent intracellular trafficking toward the nucleus during virus entry into host cell and in suppression of DAXX-mediated repression of the immediate early E1A promoter.
messages: Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus.
messages: N-terminal amphipathic alpha-helix domain is essential for the membrane lytic activity.
messages: Nucleus
messages: Pre-protein VI: During virus assembly, promotes hexon trimers nuclear import through nuclear pore complexes via an importin alpha/beta-dependent mechanism. By analogy to herpesviruses capsid assembly, might act as a chaperone to promote the formation of the icosahedral capsid.
messages: Protease cofactor: Cofactor that activates the viral protease. Binds to viral protease in a 1:1 ratio.
messages: Protease cofactor: Contains the major nuclear import and export signals. Proteolytically removed during virion maturation. The processing of the C-terminus turns the precursor into a mature viral structural protein and abrogates its ability to promote hexon import and act as a potential chaperone protein.
messages: Requires DNA and protease cofactor for maximal activation. Inside nascent virions, becomes partially activated by binding to the viral DNA, allowing it to cleave the cofactor that binds to the protease and fully activates it. Actin, like the viral protease cofactor, seems to act as a cofactor in the cleavage of cytokeratin 18 and of actin itself.
messages: Ubiquitinated by Nedd4 following partial capsid disassembly; which might play a role in intracellular virus movement during entry.
messages: Virion

108098:HAdVB1 gp03
gene id: 108098:HAdVB1_gp03
uniprot id: I6LEP7
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenoviridae hexon-interlacing protein family.
messages: Expressed in the intermediate phase of the viral replicative cycle.
messages: Homotrimer. Interacts with hexon protein; this interaction tethers the hexons together. Self-interacts with adjacent proteins. Interacts with kinesin light chain KLC1; this interaction leads to capsid disruption at the nuclear pore complex during virus entry into host cell.
messages: Host nucleus
messages: Structural component of the virion that acts as a cement protein on the capsid exterior and forms triskelion structures consisting of three molecules that stabilize three hexon trimers at the center of each icosahedral facet and fixes the peripentonal hexons. Dispensable for assembly. During virus entry, recruits the anterograde motor kinesin-1 to the capsid docked at the nuclear pore complex thereby subjecting the docked capsid to a pulling force. The resulting tension leads to capsid disruption, dispersion of capsid fragments toward cell periphery and eventually viral DNA entry into the host nucleus.
messages: This protein is only encoded by mastadenoviruses, and may therefore play a role in mammals tropism.
messages: Three N-terminal domains of hexon-interlacing protein form triskelions between hexon capsomers.
messages: Virion

108098:HAdVB1 gp09
gene id: 108098:HAdVB1_gp09
uniprot id: Q1L4D5
uniprot id: T1UFE3
names: Caution
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
messages: Belongs to the adenoviridae histone-like nucleoprotein family.
messages: Cleaved near the N-terminus by the viral protease during virion maturation to form the mature protein.
messages: Expressed in the late phase of the viral replicative cycle.
messages: Interacts with the core-capsid bridging protein; this interaction bridges the virus core to the capsid. Interacts with host NPM1; this interaction might play a role in placing the pre-histone-like nucleoprotein on the viral DNA or regulating viral gene expression. Interacts with host HMGB1; this interaction inhibits host immune response.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Plays also a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus.
messages: Virion
messages: host nucleolus

108098:HAdVB2 gp07
gene id: 108098:HAdVB2_gp07
uniprot id: Q5UW02
uniprot id: Q5UW04
uniprot id: Q5UW05
uniprot id: T1UE85
names: Caution
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
messages: Belongs to the adenoviridae hexon-linking protein family.
messages: Belongs to the adenoviridae shutoff protein family.
messages: Belongs to the adenoviridae splicing factor family.
messages: Cleaved by the viral protease during virion maturation. May cause the middle segment to be shed from the capsid.
messages: Expressed in the late phase of the viral replicative cycle.
messages: Hexon-linking protein-C: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together.
messages: Hexon-linking protein-N: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together.
messages: Host cytoplasm
messages: Host nucleus
messages: Interacts with the peripentonal hexons as well as the hexons in the facets. Part of a complex composed of the core-capsid bridging protein, the endosome lysis protein VI and the hexon-linking protein VIII; these interactions bridge the virus core to the capsid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylated. Asymmetric dimethylation by host PRMT1 of the Arg/Gly-rich region may regulate shutoff protein binding to hexon and promote the capsid assembly in the nucleus.
messages: Might be cleaved by the viral protease.
messages: Monomer. Interacts with hexon protein; this interaction allows chaperoning and trimerization of hexon proteins. Interacts (via N-terminus) with host initiation factor EIF4G (via C-terminus). Interacts (via RRM domain) with viral mRNAs that contain the tripartite leader; this interaction allows ribosome shunting and expression of viral late mRNAs.
messages: Phosphorylated. Tyrosine phosphorylation enhances preferential binding to tripartite leader mRNAs and allows ribosome shunting.
messages: Protein that inhibits host translation while promoting late viral translation by ribosome shunting. Blocks host cap-dependent translation by binding to eIF4G, displacing MKNK1 from cap initiation complexes and preventing EIF4E phosphorylation. Binds to the tripartite leader sequence of viral late mRNAs and recruits host eIF4G, PABPC1/poly-A binding protein and 40S ribosomes subunits on viral mRNAs, allowing ribosome shunting and efficient translation of late viral mRNAs even though conventional translation via ribosome scanning from the cap has been shut off in the host cell. During assembly, acts as a chaperone protein that helps hexon proteins assembly into trimers.
messages: Virion

108098:HAdVB2 gp13
gene id: 108098:HAdVB2_gp13
uniprot id: Q5UVZ6
uniprot id: Q5UVZ7
uniprot id: Q5UVZ8
uniprot id: Q5UVZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenoviridae E19 family.
messages: Belongs to the adenoviridae E3_20 family.
messages: Binds and retains class I heavy chains in the endoplasmic reticulum during the early period of virus infection, thereby impairing their transport to the cell surface. Also delays the expression of class I alleles that it cannot affect by direct retention. Binds transporters associated with antigen processing (TAP) and acts as a tapasin inhibitor, preventing class I/TAP association. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
messages: Endoplasmic reticulum membrane
messages: Host endoplasmic reticulum membrane
messages: Membrane

108098:HAdVB2 gp15
gene id: 108098:HAdVB2_gp15
uniprot id: Q5UVZ2
names: Similarity
messages: Belongs to the adenoviridae E4 30 to 34 kDa protein family.

108098:HAdVB2 gp10
gene id: 108098:HAdVB2_gp10
uniprot id: Q5UW14
uniprot id: Q5UW15
names: Caution
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
messages: Belongs to the adenoviridae hexon-linking protein IIIa family.
messages: Belongs to the adenoviridae packaging protein 3 family.
messages: Cleaved at different sites by the viral protease during virion maturation.
messages: Cleaved near the C-terminus by the viral protease during virion maturation to form the mature protein.
messages: Expressed in the early phase and late phase of the viral replicative cycle.
messages: Expressed in the late phase of the viral replicative cycle.
messages: Host nucleus
messages: Interacts with hexon proteins; this interaction tethers the peripentonal hexons to hexons situated in the facet. Interacts with the penton protein (via N-terminus). Interacts with packaging protein 3; this interaction is required to promote correct genome packaging.
messages: Involved in viral genome packaging through its interaction with packaging proteins 1 and 2. After proteolyic cleavage by adenovirus protease, L1 52/55k protein is removed from the capsid during viral maturation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the genome packaging complex composed of packaging proteins 1, 2 and 3; this complex specifically binds to the packaging sequence on the left end of viral genomic DNA and performs packaging of the viral genome. Interacts with hexon-linking protein IIIa; this interaction is required to promote correct genome packaging.
messages: Structural component of the virion that acts as a cement protein on the capsid exterior which mediates the interactions between the hexons, including the peripentonal hexons, and reaches all the way to the penton vertices. Two hexon linking proteins IIIa, one from each facet, stabilize the unique edge interface between a pair of facets. As the virus enters the host cell, hexon linking proteins IIIa are shed concomitant with virion acidification in the endosome. During virus assembly, seems to play a role in the serotype specificity of the packaging of viral DNA via its interaction with packaging protein 3.
messages: Virion

108098:HAdVB2 gp01
gene id: 108098:HAdVB2_gp01
uniprot id: Q5UW25
names: Function
names: Similarity
messages: Belongs to the adenoviridae E1A protein family.
messages: Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.

108098:HAdVB2 gp05
gene id: 108098:HAdVB2_gp05
uniprot id: Q5UW18
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenoviridae packaging protein 1 family.
messages: Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1.
messages: Expressed in the intermediate phase of the viral replicative cycle.
messages: Homodimer. Part of a genome packaging complex composed of packaging proteins 1, 2 and 3; this complex specifically binds to the packaging sequence on the left end of viral genomic DNA and performs packaging of the viral genome. Interacts with protein 33K.
messages: Virion
messages: host nucleolus
messages: host nucleoplasm

108098:HAdVB1 gp07
gene id: 108098:HAdVB1_gp07
uniprot id: I6LER0
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
messages: Belongs to the adenoviridae hexon-linking protein family.
messages: Cleaved by the viral protease during virion maturation. May cause the middle segment to be shed from the capsid.
messages: Expressed in the late phase of the viral replicative cycle.
messages: Hexon-linking protein-C: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together.
messages: Hexon-linking protein-N: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together.
messages: Host nucleus
messages: Interacts with the peripentonal hexons as well as the hexons in the facets. Part of a complex composed of the core-capsid bridging protein, the endosome lysis protein VI and the hexon-linking protein VIII; these interactions bridge the virus core to the capsid.
messages: Virion

108098:HAdVB2 gp09
gene id: 108098:HAdVB2_gp09
uniprot id: J7I661
uniprot id: Q5UW11
uniprot id: Q5UW12
uniprot id: Q5UW13
names: Caution
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
messages: Belongs to the adenoviridae core-capsid bridging protein family.
messages: Belongs to the adenoviridae histone-like nucleoprotein family.
messages: Belongs to the adenoviridae penton family.
messages: Cleaved near the N-terminus by the viral protease during virion maturation to form the mature protein.
messages: Expressed in the late phase of the viral replicative cycle.
messages: Host nucleus
messages: Interacts with the core-capsid bridging protein; this interaction bridges the virus core to the capsid. Interacts with host NPM1; this interaction might play a role in placing the pre-histone-like nucleoprotein on the viral DNA or regulating viral gene expression. Interacts with host HMGB1; this interaction inhibits host immune response.
messages: Interacts with the fiber protein (via N-terminal tail region). Interacts with the capsid vertex protein; this interaction binds the penton base to neighboring peripentonal hexons.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Major capsid protein that self-associates to form penton base pentamers, each in the shape of a pentagon, situated at the 12 vertices of the pseudo T=25 capsid. Involved in virus secondary attachment to host cell after initial attachment by the fiber protein, and in endocytosis of virions. As the virus enters the host cell, penton proteins are shed concomitant with virion acidification in the endosome.
messages: Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Plays also a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus.
messages: Virion
messages: host nucleolus