1074000:AFK65 RS07470
gene id: 1074000:AFK65_RS07470
uniprot id: A0A376E8I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CsgA/CsgB family.
messages: Fimbrium

1074000:AFK65 RS19755
gene id: 1074000:AFK65_RS19755
uniprot id: A0A376F1S3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

1074000:AFK65 RS02430
gene id: 1074000:AFK65_RS02430
uniprot id: A0A376DZL1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

1074000:AFK65 RS15895
gene id: 1074000:AFK65_RS15895
uniprot id: A0A376EUF0
names: Similarity
messages: Belongs to the SdhE FAD assembly factor family.

1074000:AFK65 RS07730
gene id: 1074000:AFK65_RS07730
uniprot id: A0A376EAI7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1074000:AFK65 RS12475
gene id: 1074000:AFK65_RS12475
uniprot id: A0A376EL48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

1074000:AFK65 RS04975
gene id: 1074000:AFK65_RS04975
uniprot id: A0A376E3M4
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS13835
gene id: 1074000:AFK65_RS13835
uniprot id: A0A376EQ65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
messages: Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS16240
gene id: 1074000:AFK65_RS16240
uniprot id: A0A376EWU4
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

1074000:AFK65 RS16585
gene id: 1074000:AFK65_RS16585
uniprot id: A0A376EX74
names: Function
messages: Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.

1074000:AFK65 RS03775
gene id: 1074000:AFK65_RS03775
uniprot id: A0A376E1V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm
messages: Purine salvage pathway enzyme which catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of hypoxanthine to yield IMP (inosine 5'-monophosphate). To a lesser extent, can also act on guanine leading to GMP, but shows a highly less efficient activity with xanthine.

1074000:AFK65 RS18375
gene id: 1074000:AFK65_RS18375
uniprot id: A0A376EZX7
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

1074000:AFK65 RS15330
gene id: 1074000:AFK65_RS15330
uniprot id: A0A376ESZ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the UbiD family. YclC subfamily.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Involved in the non-oxidative decarboxylation and detoxification of phenolic derivatives.

1074000:AFK65 RS14560
gene id: 1074000:AFK65_RS14560
uniprot id: A0A376ETK7
names: Similarity
messages: Belongs to the YfgM family.

1074000:AFK65 RS13280
gene id: 1074000:AFK65_RS13280
uniprot id: A0A376EPH6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport.

1074000:AFK65 RS11995
gene id: 1074000:AFK65_RS11995
uniprot id: A0A376EL10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
messages: Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
messages: Homotetramer.

1074000:AFK65 RS06265
gene id: 1074000:AFK65_RS06265
uniprot id: A0A376E5R9
names: Similarity
messages: Belongs to the ModE family.

1074000:AFK65 RS02845
gene id: 1074000:AFK65_RS02845
uniprot id: A0A376E0B9
names: Similarity
messages: Belongs to the glycosyl hydrolase 53 family.

1074000:AFK65 RS08195
gene id: 1074000:AFK65_RS08195
uniprot id: A0A376EB14
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

1074000:AFK65 RS16225
gene id: 1074000:AFK65_RS16225
uniprot id: A0A376EV97
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1074000:AFK65 RS12915
gene id: 1074000:AFK65_RS12915
uniprot id: A0A376EM63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS02285
gene id: 1074000:AFK65_RS02285
uniprot id: A0A376DZA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SIS family. DiaA subfamily.
messages: Homotetramer; dimer of dimers.
messages: Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.

1074000:AFK65 RS18400
gene id: 1074000:AFK65_RS18400
uniprot id: A0A376EZY8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Allosterically activated by fructose-1,6-bisphosphate (F16BP) and inhibited by AMP.
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS18000
gene id: 1074000:AFK65_RS18000
uniprot id: A0A376EZV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1074000:AFK65 RS06495
gene id: 1074000:AFK65_RS06495
uniprot id: A0A376E6I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS03665
gene id: 1074000:AFK65_RS03665
uniprot id: A0A376E1F4
names: Similarity
messages: Belongs to the GSP E family.

1074000:AFK65 RS17905
gene id: 1074000:AFK65_RS17905
uniprot id: A0A376EX94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1074000:AFK65 RS12500
gene id: 1074000:AFK65_RS12500
uniprot id: A0A376EMT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

1074000:AFK65 RS00285
gene id: 1074000:AFK65_RS00285
uniprot id: A0A376DW00
names: Similarity
messages: Belongs to the VgrG protein family.

1074000:AFK65 RS19625
gene id: 1074000:AFK65_RS19625
uniprot id: A0A376F252
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

1074000:AFK65 RS04970
gene id: 1074000:AFK65_RS04970
uniprot id: A0A376E4R3
names: Similarity
messages: Belongs to the UPF0234 family.

1074000:AFK65 RS11130
gene id: 1074000:AFK65_RS11130
uniprot id: A0A376EHF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Homodimer. Forms a complex with the accessory proteins ExbB and ExbD.
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.

1074000:AFK65 RS14770
gene id: 1074000:AFK65_RS14770
uniprot id: A0A376ESY9
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS16100
gene id: 1074000:AFK65_RS16100
uniprot id: A0A376EX63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Monomer.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1074000:AFK65 RS13380
gene id: 1074000:AFK65_RS13380
uniprot id: A0A376ENJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

1074000:AFK65 RS02545
gene id: 1074000:AFK65_RS02545
uniprot id: A0A376DZV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginine deiminase family.
messages: Cytoplasm

1074000:AFK65 RS11525
gene id: 1074000:AFK65_RS11525
uniprot id: A0A376EK82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1074000:AFK65 RS12810
gene id: 1074000:AFK65_RS12810
uniprot id: A0A376ENU6
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1074000:AFK65 RS07010
gene id: 1074000:AFK65_RS07010
uniprot id: A0A376EAC0
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS07545
gene id: 1074000:AFK65_RS07545
uniprot id: A0A376E9C1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MSOX/MTOX family. MTOX subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the oxidative demethylation of N-methyl-L-tryptophan.
messages: Monomer.

1074000:AFK65 RS09030
gene id: 1074000:AFK65_RS09030
uniprot id: A0A376EC47
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1074000:AFK65 RS07660
gene id: 1074000:AFK65_RS07660
uniprot id: A0A376EBL4
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

1074000:AFK65 RS08545
gene id: 1074000:AFK65_RS08545
uniprot id: A0A376EB88
names: Similarity
messages: Belongs to the HesB/IscA family.

1074000:AFK65 RS15450
gene id: 1074000:AFK65_RS15450
uniprot id: A0A376EU27
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

1074000:AFK65 RS18415
gene id: 1074000:AFK65_RS18415
uniprot id: A0A376EYP4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS12270
gene id: 1074000:AFK65_RS12270
uniprot id: A0A376EKF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Cell inner membrane
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

1074000:AFK65 RS17625
gene id: 1074000:AFK65_RS17625
uniprot id: A0A376EZ27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS15615
gene id: 1074000:AFK65_RS15615
uniprot id: A0A376EVU9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm
messages: Homohexamer.

1074000:AFK65 RS06040
gene id: 1074000:AFK65_RS06040
uniprot id: A0A376E597
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

1074000:AFK65 RS15950
gene id: 1074000:AFK65_RS15950
uniprot id: A0A376EUG1
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

1074000:AFK65 RS11675
gene id: 1074000:AFK65_RS11675
uniprot id: A0A376EKA2
names: Similarity
messages: Belongs to the RutC family.

1074000:AFK65 RS02260
gene id: 1074000:AFK65_RS02260
uniprot id: A0A376E068
names: Similarity
messages: Belongs to the UPF0306 family.

1074000:AFK65 RS19920
gene id: 1074000:AFK65_RS19920
uniprot id: A0A376F2G9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1074000:AFK65 RS19415
gene id: 1074000:AFK65_RS19415
uniprot id: A0A376EZ41
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigB subfamily.
messages: Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.

1074000:AFK65 RS03545
gene id: 1074000:AFK65_RS03545
uniprot id: A0A376E3F9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster.
messages: nucleoid

1074000:AFK65 RS07475
gene id: 1074000:AFK65_RS07475
uniprot id: A0A376E9Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CsgA/CsgB family.
messages: Fimbrium

1074000:AFK65 RS08510
gene id: 1074000:AFK65_RS08510
uniprot id: A0A376EB54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1074000:AFK65 RS07450
gene id: 1074000:AFK65_RS07450
uniprot id: A0A376E9X4
names: Function
names: Similarity
messages: Belongs to the CsgG family.
messages: May be involved in the biogenesis of curli organelles.

1074000:AFK65 RS17975
gene id: 1074000:AFK65_RS17975
uniprot id: A0A376F0A3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1074000:AFK65 RS06360
gene id: 1074000:AFK65_RS06360
uniprot id: A0A376E7H2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1074000:AFK65 RS18005
gene id: 1074000:AFK65_RS18005
uniprot id: A0A376EY28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1074000:AFK65 RS11855
gene id: 1074000:AFK65_RS11855
uniprot id: A0A376ELF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CopC family.
messages: Involved in copper resistance.
messages: Periplasm

1074000:AFK65 RS06890
gene id: 1074000:AFK65_RS06890
uniprot id: A0A376E7P0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

1074000:AFK65 RS14650
gene id: 1074000:AFK65_RS14650
uniprot id: A0A376ET33
names: Function
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU.

1074000:AFK65 RS10715
gene id: 1074000:AFK65_RS10715
uniprot id: A0A376EGL0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1074000:AFK65 RS03530
gene id: 1074000:AFK65_RS03530
uniprot id: A0A376E171
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1074000:AFK65 RS08605
gene id: 1074000:AFK65_RS08605
uniprot id: A0A376EE91
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1074000:AFK65 RS05690
gene id: 1074000:AFK65_RS05690
uniprot id: A0A376E586
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS07170
gene id: 1074000:AFK65_RS07170
uniprot id: A0A376E7Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PqiA family.
messages: Component of a transport pathway that contributes to membrane integrity.
messages: Membrane

1074000:AFK65 RS09685
gene id: 1074000:AFK65_RS09685
uniprot id: A0A376EDW7
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1074000:AFK65 RS14300
gene id: 1074000:AFK65_RS14300
uniprot id: A0A376ESB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioesterase PaaI family.
messages: Cytoplasm
messages: Homotetramer. Dimer of dimers. Interacts specifically with the aryl carrier protein (ArCP) domain of EntB.
messages: Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules.

1074000:AFK65 RS14400
gene id: 1074000:AFK65_RS14400
uniprot id: A0A376EQK2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

1074000:AFK65 RS06425
gene id: 1074000:AFK65_RS06425
uniprot id: A0A376E6S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. RhlE subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

1074000:AFK65 RS16000
gene id: 1074000:AFK65_RS16000
uniprot id: A0A376EX89
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
messages: Membrane

1074000:AFK65 RS12295
gene id: 1074000:AFK65_RS12295
uniprot id: A0A376EKH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS08655
gene id: 1074000:AFK65_RS08655
uniprot id: A0A376ECZ6
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

1074000:AFK65 RS16895
gene id: 1074000:AFK65_RS16895
uniprot id: A0A376EVS8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS06895
gene id: 1074000:AFK65_RS06895
uniprot id: A0A376E7A9
names: Similarity
messages: Belongs to the ClpA/ClpB family.

1074000:AFK65 RS03075
gene id: 1074000:AFK65_RS03075
uniprot id: A0A376E290
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

1074000:AFK65 RS08240
gene id: 1074000:AFK65_RS08240
uniprot id: A0A376EB50
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1074000:AFK65 RS05420
gene id: 1074000:AFK65_RS05420
uniprot id: A0A376E4Q2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1074000:AFK65 RS17255
gene id: 1074000:AFK65_RS17255
uniprot id: A0A376EWD6
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

1074000:AFK65 RS10570
gene id: 1074000:AFK65_RS10570
uniprot id: A0A376EHT5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

1074000:AFK65 RS08450
gene id: 1074000:AFK65_RS08450
uniprot id: A0A376EAX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family.
messages: Cell membrane
messages: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).

1074000:AFK65 RS18580
gene id: 1074000:AFK65_RS18580
uniprot id: A0A376EYR5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmD family.
messages: Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle.

1074000:AFK65 RS17365
gene id: 1074000:AFK65_RS17365
uniprot id: A0A376EYN6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdgT transporter family.
messages: Catalyzes the proton-dependent uptake of 2-keto-3-deoxygluconate (KDG) into the cell.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS11215
gene id: 1074000:AFK65_RS11215
uniprot id: A0A376EJN3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1074000:AFK65 RS13450
gene id: 1074000:AFK65_RS13450
uniprot id: A0A376ENA7
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS07920
gene id: 1074000:AFK65_RS07920
uniprot id: A0A376EAV3
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudJ subfamily.
messages: Monomer.

1074000:AFK65 RS18510
gene id: 1074000:AFK65_RS18510
uniprot id: A0A376F0C8
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1074000:AFK65 RS12450
gene id: 1074000:AFK65_RS12450
uniprot id: A0A376EN02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliH family.
messages: Cytoplasm
messages: Needed for flagellar regrowth and assembly.

1074000:AFK65 RS19120
gene id: 1074000:AFK65_RS19120
uniprot id: A0A376F1J9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS09955
gene id: 1074000:AFK65_RS09955
uniprot id: A0A376EG85
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1074000:AFK65 RS05855
gene id: 1074000:AFK65_RS05855
uniprot id: A0A376E6P8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1074000:AFK65 RS04570
gene id: 1074000:AFK65_RS04570
uniprot id: A0A376E312
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

1074000:AFK65 RS17055
gene id: 1074000:AFK65_RS17055
uniprot id: A0A376EY07
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS00670
gene id: 1074000:AFK65_RS00670
uniprot id: A0A376DYT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

1074000:AFK65 RS12525
gene id: 1074000:AFK65_RS12525
uniprot id: A0A376EMV9
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Homodimer.

1074000:AFK65 RS18115
gene id: 1074000:AFK65_RS18115
uniprot id: A0A376EXP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in both the arginine and lysine biosynthetic pathways.

1074000:AFK65 RS02435
gene id: 1074000:AFK65_RS02435
uniprot id: A0A376DZI9
names: Similarity
messages: Belongs to the UxaA family.

1074000:AFK65 RS01880
gene id: 1074000:AFK65_RS01880
uniprot id: A0A376DZH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AaeX family.
messages: Cell membrane

1074000:AFK65 RS15375
gene id: 1074000:AFK65_RS15375
uniprot id: A0A376ESE8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.

1074000:AFK65 RS12955
gene id: 1074000:AFK65_RS12955
uniprot id: A0A376EML0
names: Similarity
messages: Belongs to the alkylbase DNA glycosidase AlkA family.

1074000:AFK65 RS01990
gene id: 1074000:AFK65_RS01990
uniprot id: A0A376DYQ4
names: Function
names: Similarity
messages: Belongs to the peptidase C56 family.
messages: Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate.

1074000:AFK65 RS09125
gene id: 1074000:AFK65_RS09125
uniprot id: A0A376ED86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tus family.
messages: Cytoplasm
messages: Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence.

1074000:AFK65 RS12785
gene id: 1074000:AFK65_RS12785
uniprot id: K8DNB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

1074000:AFK65 RS15050
gene id: 1074000:AFK65_RS15050
uniprot id: A0A376ETV8
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1074000:AFK65 RS01400
gene id: 1074000:AFK65_RS01400
uniprot id: A0A376DYW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate.
messages: Cytoplasm

1074000:AFK65 RS08275
gene id: 1074000:AFK65_RS08275
uniprot id: A0A376ED85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

1074000:AFK65 RS15360
gene id: 1074000:AFK65_RS15360
uniprot id: A0A376ESW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoS subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.

1074000:AFK65 RS12635
gene id: 1074000:AFK65_RS12635
uniprot id: A0A376ENE3
names: Function
names: Similarity
messages: Belongs to the AMP nucleosidase family.
messages: Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.

1074000:AFK65 RS15170
gene id: 1074000:AFK65_RS15170
uniprot id: A0A376ERX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS08260
gene id: 1074000:AFK65_RS08260
uniprot id: A0A376EAE6
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family. AstD subfamily.
messages: Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.

1074000:AFK65 RS00630
gene id: 1074000:AFK65_RS00630
uniprot id: A0A376DWL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

1074000:AFK65 RS16890
gene id: 1074000:AFK65_RS16890
uniprot id: A0A376EY99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane

1074000:AFK65 RS19800
gene id: 1074000:AFK65_RS19800
uniprot id: A0A376F327
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1074000:AFK65 RS06160
gene id: 1074000:AFK65_RS06160
uniprot id: A0A376E6V8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1074000:AFK65 RS03880
gene id: 1074000:AFK65_RS03880
uniprot id: A0A376E275
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Membrane
messages: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.

1074000:AFK65 RS16080
gene id: 1074000:AFK65_RS16080
uniprot id: A0A376EU95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1074000:AFK65 RS01760
gene id: 1074000:AFK65_RS01760
uniprot id: A0A376E0I8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1074000:AFK65 RS20275
gene id: 1074000:AFK65_RS20275
uniprot id: A0A376KRS5
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS02115
gene id: 1074000:AFK65_RS02115
uniprot id: A0A376E0J4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1074000:AFK65 RS08265
gene id: 1074000:AFK65_RS08265
uniprot id: A0A376EAW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinylarginine dihydrolase family.
messages: Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
messages: Homodimer.

1074000:AFK65 RS07560
gene id: 1074000:AFK65_RS07560
uniprot id: A0A376E8P1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.

1074000:AFK65 RS11305
gene id: 1074000:AFK65_RS11305
uniprot id: A0A376EKL6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS13770
gene id: 1074000:AFK65_RS13770
uniprot id: A0A376EQK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

1074000:AFK65 RS02035
gene id: 1074000:AFK65_RS02035
uniprot id: A0A376E0W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptC family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptA and the LptBFG transporter complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA.
messages: Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

1074000:AFK65 RS16110
gene id: 1074000:AFK65_RS16110
uniprot id: A0A376EW80
names: Similarity
messages: Belongs to the UPF0235 family.

1074000:AFK65 RS13270
gene id: 1074000:AFK65_RS13270
uniprot id: A0A376EPY8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS02080
gene id: 1074000:AFK65_RS02080
uniprot id: A0A376E0B4
names: Similarity
messages: Belongs to the BolA/IbaG family.

1074000:AFK65 RS00905
gene id: 1074000:AFK65_RS00905
uniprot id: A0A376DX67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.

1074000:AFK65 RS18705
gene id: 1074000:AFK65_RS18705
uniprot id: A0A376F0P9
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1074000:AFK65 RS16325
gene id: 1074000:AFK65_RS16325
uniprot id: A0A376EX95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.
messages: Binds DNA as a monomer.
messages: Cytoplasm
messages: Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.

1074000:AFK65 RS16540
gene id: 1074000:AFK65_RS16540
uniprot id: A0A376EVX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Monomer.

1074000:AFK65 RS03475
gene id: 1074000:AFK65_RS03475
uniprot id: A0A376E173
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS07735
gene id: 1074000:AFK65_RS07735
uniprot id: A0A376E923
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

1074000:AFK65 RS02245
gene id: 1074000:AFK65_RS02245
uniprot id: A0A376E169
names: Function
names: Similarity
messages: Belongs to the UbiT family.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Likely functions as an accessory factor.

1074000:AFK65 RS02145
gene id: 1074000:AFK65_RS02145
uniprot id: A0A376DYY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

1074000:AFK65 RS17580
gene id: 1074000:AFK65_RS17580
uniprot id: A0A376EYZ9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

1074000:AFK65 RS14065
gene id: 1074000:AFK65_RS14065
uniprot id: A0A376ERF6
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

1074000:AFK65 RS16520
gene id: 1074000:AFK65_RS16520
uniprot id: A0A376EXN8
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

1074000:AFK65 RS03340
gene id: 1074000:AFK65_RS03340
uniprot id: A0A376E157
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
messages: Homodimer.

1074000:AFK65 RS03080
gene id: 1074000:AFK65_RS03080
uniprot id: A0A376E0K8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: Homohexamer; trimer of homodimers.

1074000:AFK65 RS14405
gene id: 1074000:AFK65_RS14405
uniprot id: A0A376ESJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0370 family.
messages: Cell membrane

1074000:AFK65 RS10320
gene id: 1074000:AFK65_RS10320
uniprot id: A0A376EFN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family.
messages: Membrane

1074000:AFK65 RS17240
gene id: 1074000:AFK65_RS17240
uniprot id: A0A376EZB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1074000:AFK65 RS01630
gene id: 1074000:AFK65_RS01630
uniprot id: A0A376E0D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

1074000:AFK65 RS10335
gene id: 1074000:AFK65_RS10335
uniprot id: A0A376EHC8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1074000:AFK65 RS13800
gene id: 1074000:AFK65_RS13800
uniprot id: A0A376ENS8
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS06760
gene id: 1074000:AFK65_RS06760
uniprot id: A0A376E7T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS04070
gene id: 1074000:AFK65_RS04070
uniprot id: A0A376E267
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS16545
gene id: 1074000:AFK65_RS16545
uniprot id: A0A376EXG7
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

1074000:AFK65 RS17275
gene id: 1074000:AFK65_RS17275
uniprot id: A0A376EYE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS04875
gene id: 1074000:AFK65_RS04875
uniprot id: A0A376E3H4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

1074000:AFK65 RS02540
gene id: 1074000:AFK65_RS02540
uniprot id: A0A376DZR7
names: Similarity
messages: Belongs to the carbamate kinase family.

1074000:AFK65 RS16010
gene id: 1074000:AFK65_RS16010
uniprot id: A0A376EX96
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1074000:AFK65 RS01735
gene id: 1074000:AFK65_RS01735
uniprot id: A0A376DYD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS06170
gene id: 1074000:AFK65_RS06170
uniprot id: A0A376E6W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TolB family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.
messages: Periplasm
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1074000:AFK65 RS00550
gene id: 1074000:AFK65_RS00550
uniprot id: A0A376DYM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the rhamnose mutarotase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the anomeric conversion of L-rhamnose.

1074000:AFK65 RS13375
gene id: 1074000:AFK65_RS13375
uniprot id: A0A376EP18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1074000:AFK65 RS15180
gene id: 1074000:AFK65_RS15180
uniprot id: A0A376ETE8
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS03180
gene id: 1074000:AFK65_RS03180
uniprot id: A0A376E0Q5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1074000:AFK65 RS18545
gene id: 1074000:AFK65_RS18545
uniprot id: A0A376F047
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS09130
gene id: 1074000:AFK65_RS09130
uniprot id: A0A376ECZ9
names: Subcellular Location Annotation
messages: Cell inner membrane

1074000:AFK65 RS08480
gene id: 1074000:AFK65_RS08480
uniprot id: A0A376ECJ7
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

1074000:AFK65 RS19315
gene id: 1074000:AFK65_RS19315
uniprot id: A0A376F0X2
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS10915
gene id: 1074000:AFK65_RS10915
uniprot id: A0A376EHV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS04980
gene id: 1074000:AFK65_RS04980
uniprot id: A0A376E431
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

1074000:AFK65 RS13935
gene id: 1074000:AFK65_RS13935
uniprot id: A0A376EPX0
names: Function
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Possible subunit of a heme lyase.

1074000:AFK65 RS14235
gene id: 1074000:AFK65_RS14235
uniprot id: A0A376ERR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

1074000:AFK65 RS11645
gene id: 1074000:AFK65_RS11645
uniprot id: A0A376EJ21
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

1074000:AFK65 RS05650
gene id: 1074000:AFK65_RS05650
uniprot id: A0A376E4M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1074000:AFK65 RS03675
gene id: 1074000:AFK65_RS03675
uniprot id: A0A376E1N9
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

1074000:AFK65 RS06365
gene id: 1074000:AFK65_RS06365
uniprot id: A0A376E662
names: Similarity
messages: Belongs to the MoaD family.

1074000:AFK65 RS09965
gene id: 1074000:AFK65_RS09965
uniprot id: A0A376EEN3
names: Similarity
messages: Belongs to the VgrG protein family.

1074000:AFK65 RS15860
gene id: 1074000:AFK65_RS15860
uniprot id: A0A376EV87
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS03455
gene id: 1074000:AFK65_RS03455
uniprot id: A0A376E137
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldolase class II family. AraD/FucA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction).

1074000:AFK65 RS11295
gene id: 1074000:AFK65_RS11295
uniprot id: A0A376EHQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS04985
gene id: 1074000:AFK65_RS04985
uniprot id: A0A376E570
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase bacterial subunit 4 family.
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

1074000:AFK65 RS01985
gene id: 1074000:AFK65_RS01985
uniprot id: A0A376DZM7
names: PTM
names: Subcellular Location Annotation
messages: Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS16725
gene id: 1074000:AFK65_RS16725
uniprot id: A0A376EYY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
messages: Membrane
messages: The accessory proteins ExbB and ExbD seem to form a complex with TonB.

1074000:AFK65 RS12465
gene id: 1074000:AFK65_RS12465
uniprot id: A0A376EML7
names: Function
names: Similarity
messages: Belongs to the FliK family.
messages: Controls the length of the flagellar hook.

1074000:AFK65 RS03710
gene id: 1074000:AFK65_RS03710
uniprot id: A0A376E3P3
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

1074000:AFK65 RS08565
gene id: 1074000:AFK65_RS08565
uniprot id: A0A376EBA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo.
messages: Cytoplasm
messages: Homodimer. Interacts with SufE and the SufBCD complex composed of SufB, SufC and SufD. The interaction with SufE is required to mediate the direct transfer of the sulfur atom from the S-sulfanylcysteine.

1074000:AFK65 RS02520
gene id: 1074000:AFK65_RS02520
uniprot id: A0A376E162
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1074000:AFK65 RS15675
gene id: 1074000:AFK65_RS15675
uniprot id: A0A376EV56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MutH family.
messages: Cytoplasm
messages: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.

1074000:AFK65 RS10550
gene id: 1074000:AFK65_RS10550
uniprot id: A0A376EGR6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS02195
gene id: 1074000:AFK65_RS02195
uniprot id: A0A376DZX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1074000:AFK65 RS15875
gene id: 1074000:AFK65_RS15875
uniprot id: A0A376EUD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.

1074000:AFK65 RS01955
gene id: 1074000:AFK65_RS01955
uniprot id: A0A376E0T5
names: Similarity
messages: Belongs to the GST superfamily. HSP26 family.

1074000:AFK65 RS08500
gene id: 1074000:AFK65_RS08500
uniprot id: A0A376EB30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
messages: Membrane

1074000:AFK65 RS13170
gene id: 1074000:AFK65_RS13170
uniprot id: A0A376EQ92
names: Function
names: Similarity
messages: Belongs to the Dus family. DusC subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs.

1074000:AFK65 RS10545
gene id: 1074000:AFK65_RS10545
uniprot id: A0A376EHV3
names: Similarity
messages: Belongs to the 2-oxoadipate dioxygenase/decarboxylase family.

1074000:AFK65 RS13735
gene id: 1074000:AFK65_RS13735
uniprot id: A0A376EQH9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1074000:AFK65 RS18880
gene id: 1074000:AFK65_RS18880
uniprot id: A0A376F0H2
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS08730
gene id: 1074000:AFK65_RS08730
uniprot id: A0A376EC60
names: Function
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.

1074000:AFK65 RS04235
gene id: 1074000:AFK65_RS04235
uniprot id: A0A376E297
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
messages: Cell membrane
messages: Homotetramer.
messages: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.

1074000:AFK65 RS18015
gene id: 1074000:AFK65_RS18015
uniprot id: A0A376EY85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DsrH/TusB family.
messages: Cytoplasm
messages: Heterohexamer, formed by a dimer of trimers. The hexameric TusBCD complex contains 2 copies each of TusB, TusC and TusD. The TusBCD complex interacts with TusE.
messages: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.

1074000:AFK65 RS14575
gene id: 1074000:AFK65_RS14575
uniprot id: A0A376EQZ6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RodZ family.
messages: Cell inner membrane
messages: Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.
messages: The helix-turn-helix (HTH) motif in the cytoplasmic domain of the N-terminus is involved in the formation of spirals to maintain the rigid rod shape. As this protein is anchored in the cytoplasmic membrane, the HTH motif may contribute to protein-protein interactions to form the RodZ helix, which is localized beneath the cytoplasmic membrane. The C-terminal domain may be critical for determination of the rod shape by probably interacting with enzymes required for synthesis of the peptidoglycan layer, including PBPs in the periplasm.

1074000:AFK65 RS10440
gene id: 1074000:AFK65_RS10440
uniprot id: A0A376EFU6
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1074000:AFK65 RS10865
gene id: 1074000:AFK65_RS10865
uniprot id: A0A376EHH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS02050
gene id: 1074000:AFK65_RS02050
uniprot id: A0A376E0Y2
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS10460
gene id: 1074000:AFK65_RS10460
uniprot id: A0A376EHX5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS02945
gene id: 1074000:AFK65_RS02945
uniprot id: A0A376E1E9
names: Function
names: Similarity
messages: Belongs to the DnaT family.
messages: This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.

1074000:AFK65 RS11540
gene id: 1074000:AFK65_RS11540
uniprot id: A0A376EI53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase Slt family.
messages: Cell outer membrane
messages: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain.

1074000:AFK65 RS18505
gene id: 1074000:AFK65_RS18505
uniprot id: A0A376EXY4
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1074000:AFK65 RS05580
gene id: 1074000:AFK65_RS05580
uniprot id: A0A376E538
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1074000:AFK65 RS19385
gene id: 1074000:AFK65_RS19385
uniprot id: A0A376F1C7
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

1074000:AFK65 RS04560
gene id: 1074000:AFK65_RS04560
uniprot id: A0A376E3C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1074000:AFK65 RS11205
gene id: 1074000:AFK65_RS11205
uniprot id: A0A376EHQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone-like protein H-NS family.
messages: nucleoid

1074000:AFK65 RS01565
gene id: 1074000:AFK65_RS01565
uniprot id: A0A376DZ29
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS04825
gene id: 1074000:AFK65_RS04825
uniprot id: A0A376E3R5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

1074000:AFK65 RS04100
gene id: 1074000:AFK65_RS04100
uniprot id: A0A376E2G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

1074000:AFK65 RS11730
gene id: 1074000:AFK65_RS11730
uniprot id: A0A376EIM5
names: Similarity
messages: Belongs to the UPF0053 family.

1074000:AFK65 RS05810
gene id: 1074000:AFK65_RS05810
uniprot id: A0A376E4Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptE lipoprotein family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.
messages: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.

1074000:AFK65 RS18610
gene id: 1074000:AFK65_RS18610
uniprot id: A0A376F1R8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1074000:AFK65 RS08620
gene id: 1074000:AFK65_RS08620
uniprot id: A0A376EBX5
names: Similarity
messages: Belongs to the glutamine synthetase family.

1074000:AFK65 RS04705
gene id: 1074000:AFK65_RS04705
uniprot id: A0A376E3J3
names: Function
names: Similarity
messages: Belongs to the IprA family.
messages: Involved in oxidative stress resistance.

1074000:AFK65 RS05270
gene id: 1074000:AFK65_RS05270
uniprot id: A0A376E4I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1074000:AFK65 RS06020
gene id: 1074000:AFK65_RS06020
uniprot id: A0A376E5P1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1074000:AFK65 RS19200
gene id: 1074000:AFK65_RS19200
uniprot id: A0A376EZD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

1074000:AFK65 RS13940
gene id: 1074000:AFK65_RS13940
uniprot id: A0A376EP65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbE subfamily.
messages: Cell inner membrane

1074000:AFK65 RS11530
gene id: 1074000:AFK65_RS11530
uniprot id: A0A376EJ28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1074000:AFK65 RS12230
gene id: 1074000:AFK65_RS12230
uniprot id: A0A376EM94
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1074000:AFK65 RS19035
gene id: 1074000:AFK65_RS19035
uniprot id: A0A376EYG8
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

1074000:AFK65 RS07075
gene id: 1074000:AFK65_RS07075
uniprot id: A0A376E9K5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family. MukB subfamily.
messages: Homodimerization via its hinge domain. Binds to DNA via its C-terminal region. Interacts, and probably forms a ternary complex, with MukE and MukF via its C-terminal region. The complex formation is stimulated by calcium or magnesium. Interacts with tubulin-related protein FtsZ.
messages: Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
messages: The hinge domain, which separates the large intramolecular coiled coil regions, allows the homodimerization, forming a V-shaped homodimer.
messages: nucleoid

1074000:AFK65 RS06770
gene id: 1074000:AFK65_RS06770
uniprot id: A0A376E8C0
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.

1074000:AFK65 RS00635
gene id: 1074000:AFK65_RS00635
uniprot id: A0A376DYR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapB family.
messages: Cytoplasm
messages: Homodimer. The ends of the coiled-coil dimer bind to each other, forming polymers. Interacts with FtsZ.
messages: Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.

1074000:AFK65 RS03445
gene id: 1074000:AFK65_RS03445
uniprot id: A0A376E132
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
messages: Interacts with the RNAP. Has a higher affinity for the core RNAP than for the holoenzyme. Its ATPase activity is stimulated by binding to RNAP.
messages: Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair.

1074000:AFK65 RS01490
gene id: 1074000:AFK65_RS01490
uniprot id: A0A376DZQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

1074000:AFK65 RS16690
gene id: 1074000:AFK65_RS16690
uniprot id: A0A376EYW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1074000:AFK65 RS05945
gene id: 1074000:AFK65_RS05945
uniprot id: A0A376E6T3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1074000:AFK65 RS08675
gene id: 1074000:AFK65_RS08675
uniprot id: A0A376ECC3
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS06990
gene id: 1074000:AFK65_RS06990
uniprot id: A0A376E8D7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1074000:AFK65 RS05255
gene id: 1074000:AFK65_RS05255
uniprot id: A0A376E452
names: Subcellular Location Annotation
messages: Cell inner membrane

1074000:AFK65 RS11405
gene id: 1074000:AFK65_RS11405
uniprot id: A0A376EIX1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1074000:AFK65 RS11800
gene id: 1074000:AFK65_RS11800
uniprot id: A0A376EL08
names: Similarity
messages: Belongs to the peptidase S41A family.

1074000:AFK65 RS03620
gene id: 1074000:AFK65_RS03620
uniprot id: A0A376E1D2
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

1074000:AFK65 RS03945
gene id: 1074000:AFK65_RS03945
uniprot id: A0A376E1Y2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS15595
gene id: 1074000:AFK65_RS15595
uniprot id: A0A376EVZ1
names: Function
messages: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.

1074000:AFK65 RS16015
gene id: 1074000:AFK65_RS16015
uniprot id: A0A376EVP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
messages: Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
messages: Cytoplasm
messages: Homotetramer.

1074000:AFK65 RS18355
gene id: 1074000:AFK65_RS18355
uniprot id: A0A376F0A6
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by ATP and maltotriose, which are both required for DNA binding.
messages: Belongs to the MalT family.
messages: Monomer in solution. Oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.
messages: Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.

1074000:AFK65 RS17320
gene id: 1074000:AFK65_RS17320
uniprot id: A0A376EZ03
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

1074000:AFK65 RS14815
gene id: 1074000:AFK65_RS14815
uniprot id: A0A376ETU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1074000:AFK65 RS08555
gene id: 1074000:AFK65_RS08555
uniprot id: A0A376EB97
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1074000:AFK65 RS11270
gene id: 1074000:AFK65_RS11270
uniprot id: A0A376EHU7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1074000:AFK65 RS19390
gene id: 1074000:AFK65_RS19390
uniprot id: A0A376F137
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoid occlusion factor SlmA family.
messages: Homodimer. Interacts with FtsZ.
messages: Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
messages: nucleoid

1074000:AFK65 RS03715
gene id: 1074000:AFK65_RS03715
uniprot id: A0A376E1G0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 3 lipoyl cofactors covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

1074000:AFK65 RS10810
gene id: 1074000:AFK65_RS10810
uniprot id: A0A376EGP4
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1074000:AFK65 RS04335
gene id: 1074000:AFK65_RS04335
uniprot id: A0A376E2Q9
names: Similarity
messages: Belongs to the peptidase M16 family.

1074000:AFK65 RS03635
gene id: 1074000:AFK65_RS03635
uniprot id: A0A376E2W4
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1074000:AFK65 RS11135
gene id: 1074000:AFK65_RS11135
uniprot id: A0A376EHH0
names: Similarity
messages: Belongs to the YciI family.

1074000:AFK65 RS11570
gene id: 1074000:AFK65_RS11570
uniprot id: A0A376EL02
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS12610
gene id: 1074000:AFK65_RS12610
uniprot id: A0A376EN26
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS06910
gene id: 1074000:AFK65_RS06910
uniprot id: A0A376E8L7
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS15085
gene id: 1074000:AFK65_RS15085
uniprot id: A0A376ETZ5
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1074000:AFK65 RS00425
gene id: 1074000:AFK65_RS00425
uniprot id: A0A376DWK8
names: Similarity
messages: Belongs to the FBPase class 2 family.

1074000:AFK65 RS05410
gene id: 1074000:AFK65_RS05410
uniprot id: A0A376E4R8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1074000:AFK65 RS19695
gene id: 1074000:AFK65_RS19695
uniprot id: A0A376F276
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1074000:AFK65 RS14395
gene id: 1074000:AFK65_RS14395
uniprot id: A0A376ESI2
names: Similarity
messages: Belongs to the ArsC family.

1074000:AFK65 RS03525
gene id: 1074000:AFK65_RS03525
uniprot id: A0A376E2U0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS12545
gene id: 1074000:AFK65_RS12545
uniprot id: A0A376EN78
names: Function
names: Similarity
messages: Belongs to the vsr family.
messages: May nick specific sequences that contain T:G mispairs resulting from m5C-deamination.

1074000:AFK65 RS06230
gene id: 1074000:AFK65_RS06230
uniprot id: A0A376E647
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

1074000:AFK65 RS18645
gene id: 1074000:AFK65_RS18645
uniprot id: A0A376EYB5
names: Similarity
messages: Belongs to the peptidase C40 family.

1074000:AFK65 RS02295
gene id: 1074000:AFK65_RS02295
uniprot id: A0A376E0S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LpoA family.
messages: Cell outer membrane
messages: Interacts with PBP1a.
messages: Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).

1074000:AFK65 RS06480
gene id: 1074000:AFK65_RS06480
uniprot id: A0A376E6H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 1618 of 23S rRNA.

1074000:AFK65 RS07360
gene id: 1074000:AFK65_RS07360
uniprot id: A0A376E879
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS03440
gene id: 1074000:AFK65_RS03440
uniprot id: A0A376E3A7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1074000:AFK65 RS11450
gene id: 1074000:AFK65_RS11450
uniprot id: A0A376EI42
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1074000:AFK65 RS19435
gene id: 1074000:AFK65_RS19435
uniprot id: A0A376EZV0
names: Caution
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS18095
gene id: 1074000:AFK65_RS18095
uniprot id: A0A376EZL0
names: Similarity
messages: Belongs to the phosphoribulokinase family.

1074000:AFK65 RS03900
gene id: 1074000:AFK65_RS03900
uniprot id: A0A376E280
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
messages: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
messages: Homodimer.

1074000:AFK65 RS12030
gene id: 1074000:AFK65_RS12030
uniprot id: A0A376EMU4
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

1074000:AFK65 RS17800
gene id: 1074000:AFK65_RS17800
uniprot id: A0A376EZ90
names: Similarity
messages: Belongs to the Smg family.

1074000:AFK65 RS13885
gene id: 1074000:AFK65_RS13885
uniprot id: A0A376EP12
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

1074000:AFK65 RS06905
gene id: 1074000:AFK65_RS06905
uniprot id: A0A376E8T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

1074000:AFK65 RS02130
gene id: 1074000:AFK65_RS02130
uniprot id: A0A376DZ26
names: Similarity
messages: Belongs to the peptidase S13 family.

1074000:AFK65 RS15265
gene id: 1074000:AFK65_RS15265
uniprot id: A0A376ESM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1074000:AFK65 RS17075
gene id: 1074000:AFK65_RS17075
uniprot id: A0A376EW83
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1074000:AFK65 RS10445
gene id: 1074000:AFK65_RS10445
uniprot id: A0A376EG15
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS05085
gene id: 1074000:AFK65_RS05085
uniprot id: A0A376E458
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. Cof family.
messages: Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

1074000:AFK65 RS02275
gene id: 1074000:AFK65_RS02275
uniprot id: A0A376E0R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS10900
gene id: 1074000:AFK65_RS10900
uniprot id: A0A376EGW0
names: Similarity
messages: Belongs to the PspA/IM30 family.

1074000:AFK65 RS01825
gene id: 1074000:AFK65_RS01825
uniprot id: A0A376DYS1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the MsrP family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

1074000:AFK65 RS19210
gene id: 1074000:AFK65_RS19210
uniprot id: A0A376EZL8
names: Subcellular Location Annotation
messages: Cell inner membrane

1074000:AFK65 RS07915
gene id: 1074000:AFK65_RS07915
uniprot id: A0A376E9T0
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS04225
gene id: 1074000:AFK65_RS04225
uniprot id: A0A376E2D0
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

1074000:AFK65 RS12765
gene id: 1074000:AFK65_RS12765
uniprot id: A0A376EPA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1074000:AFK65 RS14795
gene id: 1074000:AFK65_RS14795
uniprot id: A0A376ETU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

1074000:AFK65 RS06915
gene id: 1074000:AFK65_RS06915
uniprot id: A0A376E7G7
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS13705
gene id: 1074000:AFK65_RS13705
uniprot id: A0A376EQE9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1074000:AFK65 RS17815
gene id: 1074000:AFK65_RS17815
uniprot id: A0A376EZL1
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1074000:AFK65 RS07840
gene id: 1074000:AFK65_RS07840
uniprot id: A0A376E9N6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
messages: The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).

1074000:AFK65 RS19360
gene id: 1074000:AFK65_RS19360
uniprot id: A0A376EZS6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

1074000:AFK65 RS03240
gene id: 1074000:AFK65_RS03240
uniprot id: A0A376E146
names: Similarity
messages: Belongs to the UPF0246 family.

1074000:AFK65 RS18635
gene id: 1074000:AFK65_RS18635
uniprot id: A0A376F1T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. YhhS family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS09215
gene id: 1074000:AFK65_RS09215
uniprot id: A0A376EFL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS19225
gene id: 1074000:AFK65_RS19225
uniprot id: A0A376EZE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1074000:AFK65 RS01425
gene id: 1074000:AFK65_RS01425
uniprot id: A0A376DYB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1074000:AFK65 RS15745
gene id: 1074000:AFK65_RS15745
uniprot id: A0A376EWI0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS11970
gene id: 1074000:AFK65_RS11970
uniprot id: A0A376EKY9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS15070
gene id: 1074000:AFK65_RS15070
uniprot id: A0A376ERJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1074000:AFK65 RS19605
gene id: 1074000:AFK65_RS19605
uniprot id: A0A376F1M4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.

1074000:AFK65 RS02640
gene id: 1074000:AFK65_RS02640
uniprot id: A0A376DZW2
names: Similarity
messages: Belongs to the glycosyl hydrolase 24 family.

1074000:AFK65 RS12770
gene id: 1074000:AFK65_RS12770
uniprot id: A0A376ENP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1074000:AFK65 RS05370
gene id: 1074000:AFK65_RS05370
uniprot id: A0A376E4A9
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1074000:AFK65 RS09050
gene id: 1074000:AFK65_RS09050
uniprot id: A0A376EDU0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1074000:AFK65 RS18345
gene id: 1074000:AFK65_RS18345
uniprot id: A0A376EZW8
names: Similarity
messages: Belongs to the disproportionating enzyme family.

1074000:AFK65 RS02555
gene id: 1074000:AFK65_RS02555
uniprot id: A0A376DZT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1074000:AFK65 RS16265
gene id: 1074000:AFK65_RS16265
uniprot id: A0A376EY16
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

1074000:AFK65 RS06815
gene id: 1074000:AFK65_RS06815
uniprot id: A0A376E727
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS15670
gene id: 1074000:AFK65_RS15670
uniprot id: A0A376EVF4
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

1074000:AFK65 RS06255
gene id: 1074000:AFK65_RS06255
uniprot id: A0A376E7H9
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1074000:AFK65 RS06585
gene id: 1074000:AFK65_RS06585
uniprot id: A0A376E877
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1074000:AFK65 RS18040
gene id: 1074000:AFK65_RS18040
uniprot id: A0A376EY92
names: Similarity
messages: Belongs to the SlyX family.

1074000:AFK65 RS18900
gene id: 1074000:AFK65_RS18900
uniprot id: A0A376F243
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1074000:AFK65 RS03745
gene id: 1074000:AFK65_RS03745
uniprot id: A0A376E3S3
names: Similarity
messages: Belongs to the UPF0231 family.

1074000:AFK65 RS04215
gene id: 1074000:AFK65_RS04215
uniprot id: A0A376E4J2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1074000:AFK65 RS18730
gene id: 1074000:AFK65_RS18730
uniprot id: A0A376EYY2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS10890
gene id: 1074000:AFK65_RS10890
uniprot id: A0A376EHJ2
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS00080
gene id: 1074000:AFK65_RS00080
uniprot id: A0A376DVX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Monomer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to monomers at high temperatures or high ionic concentrations.

1074000:AFK65 RS18045
gene id: 1074000:AFK65_RS18045
uniprot id: A0A376EZI3
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1074000:AFK65 RS18930
gene id: 1074000:AFK65_RS18930
uniprot id: A0A376F247
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS12850
gene id: 1074000:AFK65_RS12850
uniprot id: A0A376ENZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

1074000:AFK65 RS02445
gene id: 1074000:AFK65_RS02445
uniprot id: A0A376DZT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell membrane
messages: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
messages: Membrane

1074000:AFK65 RS11990
gene id: 1074000:AFK65_RS11990
uniprot id: A0A376EM07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
messages: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
messages: Homodimer.

1074000:AFK65 RS11495
gene id: 1074000:AFK65_RS11495
uniprot id: A0A376EJT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS11005
gene id: 1074000:AFK65_RS11005
uniprot id: A0A376EIW4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapA family.
messages: Cell inner membrane
messages: Involved in the assembly of lipopolysaccharide (LPS).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS08095
gene id: 1074000:AFK65_RS08095
uniprot id: A0A376E9S5
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

1074000:AFK65 RS03610
gene id: 1074000:AFK65_RS03610
uniprot id: A0A376E2V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

1074000:AFK65 RS16005
gene id: 1074000:AFK65_RS16005
uniprot id: A0A376EVX6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

1074000:AFK65 RS05395
gene id: 1074000:AFK65_RS05395
uniprot id: A0A376E6P2
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS01915
gene id: 1074000:AFK65_RS01915
uniprot id: A0A376DYW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

1074000:AFK65 RS04255
gene id: 1074000:AFK65_RS04255
uniprot id: A0A376E2M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

1074000:AFK65 RS12700
gene id: 1074000:AFK65_RS12700
uniprot id: A0A376ELA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA gyrase inhibitor family.
messages: Cytoplasm
messages: Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell.
messages: Interacts with DNA gyrase.

1074000:AFK65 RS15910
gene id: 1074000:AFK65_RS15910
uniprot id: A0A376EVE5
names: Function
names: Similarity
messages: Belongs to the N(4)-acetylcytidine amidohydrolase family.
messages: Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).

1074000:AFK65 RS15285
gene id: 1074000:AFK65_RS15285
uniprot id: A0A376ES73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS04550
gene id: 1074000:AFK65_RS04550
uniprot id: A0A376E438
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS17480
gene id: 1074000:AFK65_RS17480
uniprot id: A0A376EWT0
names: Function
names: Subunit
messages: Homotetramer.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

1074000:AFK65 RS15970
gene id: 1074000:AFK65_RS15970
uniprot id: A0A376EUH7
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1074000:AFK65 RS05400
gene id: 1074000:AFK65_RS05400
uniprot id: A0A376E483
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SelU family.
messages: Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
messages: Monomer.

1074000:AFK65 RS01420
gene id: 1074000:AFK65_RS01420
uniprot id: A0A376DY09
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC1 family. UbiB subfamily.
messages: Cell membrane
messages: Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS05565
gene id: 1074000:AFK65_RS05565
uniprot id: A0A376E529
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS01945
gene id: 1074000:AFK65_RS01945
uniprot id: A0A376E041
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1074000:AFK65 RS06535
gene id: 1074000:AFK65_RS06535
uniprot id: A0A376E745
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1074000:AFK65 RS18850
gene id: 1074000:AFK65_RS18850
uniprot id: A0A376F0J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

1074000:AFK65 RS07115
gene id: 1074000:AFK65_RS07115
uniprot id: A0A376E8N6
names: Similarity
messages: Belongs to the peptidase M1 family.

1074000:AFK65 RS01600
gene id: 1074000:AFK65_RS01600
uniprot id: A0A376DYH3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1074000:AFK65 RS05365
gene id: 1074000:AFK65_RS05365
uniprot id: A0A376E5W6
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS08885
gene id: 1074000:AFK65_RS08885
uniprot id: A0A376ECF6
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1074000:AFK65 RS17010
gene id: 1074000:AFK65_RS17010
uniprot id: A0A376EVZ7
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1074000:AFK65 RS14670
gene id: 1074000:AFK65_RS14670
uniprot id: A0A376ER58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

1074000:AFK65 RS12200
gene id: 1074000:AFK65_RS12200
uniprot id: A0A376ELH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane
messages: Responsible for the transport of C4-dicarboxylates.

1074000:AFK65 RS16045
gene id: 1074000:AFK65_RS16045
uniprot id: A0A376EW10
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

1074000:AFK65 RS03670
gene id: 1074000:AFK65_RS03670
uniprot id: A0A376E1P0
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS07355
gene id: 1074000:AFK65_RS07355
uniprot id: A0A376E8V7
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family.
messages: In the N-terminal section; belongs to the proline dehydrogenase family.
messages: Oxidizes proline to glutamate for use as a carbon and nitrogen source.

1074000:AFK65 RS05205
gene id: 1074000:AFK65_RS05205
uniprot id: A0A376E426
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

1074000:AFK65 RS14340
gene id: 1074000:AFK65_RS14340
uniprot id: A0A376ESE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1074000:AFK65 RS11400
gene id: 1074000:AFK65_RS11400
uniprot id: A0A376EI16
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1074000:AFK65 RS09055
gene id: 1074000:AFK65_RS09055
uniprot id: A0A376EDV5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1074000:AFK65 RS08230
gene id: 1074000:AFK65_RS08230
uniprot id: A0A376EAT6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Binds two Mg(2+) per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1074000:AFK65 RS17790
gene id: 1074000:AFK65_RS17790
uniprot id: A0A376EZK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family. TsaC subfamily.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.

1074000:AFK65 RS13520
gene id: 1074000:AFK65_RS13520
uniprot id: A0A376ENF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

1074000:AFK65 RS06825
gene id: 1074000:AFK65_RS06825
uniprot id: A0A376E7Q0
names: Similarity
messages: Belongs to the UPF0145 family.

1074000:AFK65 RS07160
gene id: 1074000:AFK65_RS07160
uniprot id: A0A376E8H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmKL family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.

1074000:AFK65 RS12410
gene id: 1074000:AFK65_RS12410
uniprot id: A0A376EKU1
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

1074000:AFK65 RS20435
gene id: 1074000:AFK65_RS20435
uniprot id: A0A376KU95
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS11340
gene id: 1074000:AFK65_RS11340
uniprot id: A0A376EJH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS14355
gene id: 1074000:AFK65_RS14355
uniprot id: A0A376EQG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1074000:AFK65 RS10990
gene id: 1074000:AFK65_RS10990
uniprot id: A0A376EH60
names: Similarity
messages: Belongs to the SUI1 family.

1074000:AFK65 RS09005
gene id: 1074000:AFK65_RS09005
uniprot id: A0A376ECQ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.

1074000:AFK65 RS07715
gene id: 1074000:AFK65_RS07715
uniprot id: A0A376EAF3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1074000:AFK65 RS05300
gene id: 1074000:AFK65_RS05300
uniprot id: A0A376E5B1
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

1074000:AFK65 RS13285
gene id: 1074000:AFK65_RS13285
uniprot id: A0A376EML6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Set transporter family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS08170
gene id: 1074000:AFK65_RS08170
uniprot id: A0A376EA04
names: Similarity
messages: Belongs to the UPF0229 family.

1074000:AFK65 RS08020
gene id: 1074000:AFK65_RS08020
uniprot id: A0A376EBH5
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1074000:AFK65 RS13215
gene id: 1074000:AFK65_RS13215
uniprot id: A0A376EPT6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Periplasm
messages: The ABC transporter complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).

1074000:AFK65 RS13490
gene id: 1074000:AFK65_RS13490
uniprot id: A0A376EPA3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1074000:AFK65 RS18775
gene id: 1074000:AFK65_RS18775
uniprot id: A0A376F0D4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate across the membrane.

1074000:AFK65 RS12760
gene id: 1074000:AFK65_RS12760
uniprot id: A0A376END1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1074000:AFK65 RS09110
gene id: 1074000:AFK65_RS09110
uniprot id: A0A376ECE7
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

1074000:AFK65 RS03615
gene id: 1074000:AFK65_RS03615
uniprot id: A0A376E1E3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1074000:AFK65 RS21380
gene id: 1074000:AFK65_RS21380
uniprot id: A0A376F0Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1074000:AFK65 RS12240
gene id: 1074000:AFK65_RS12240
uniprot id: A0A376EMK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

1074000:AFK65 RS04340
gene id: 1074000:AFK65_RS04340
uniprot id: A0A376E432
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. PqqE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
messages: Interacts with PqqD. The interaction is necessary for activity of PqqE.

1074000:AFK65 RS07145
gene id: 1074000:AFK65_RS07145
uniprot id: A0A376E8G6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

1074000:AFK65 RS20360
gene id: 1074000:AFK65_RS20360
uniprot id: A0A376KSA2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArsB family.
messages: Cell membrane
messages: Involved in arsenical resistance. Thought to form the channel of an arsenite pump.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1074000:AFK65 RS08455
gene id: 1074000:AFK65_RS08455
uniprot id: A0A376ECG1
names: Similarity
messages: Belongs to the peptidase C40 family.

1074000:AFK65 RS03425
gene id: 1074000:AFK65_RS03425
uniprot id: A0A376E2K8
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
messages: Periplasm
messages: The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

1074000:AFK65 RS11720
gene id: 1074000:AFK65_RS11720
uniprot id: A0A376EIL0
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1074000:AFK65 RS00485
gene id: 1074000:AFK65_RS00485
uniprot id: A0A376DWD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhE family.
messages: Cytoplasm
messages: Necessary for formate dehydrogenase activity.

1074000:AFK65 RS07645
gene id: 1074000:AFK65_RS07645
uniprot id: A0A376E8R1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: Membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

1074000:AFK65 RS18160
gene id: 1074000:AFK65_RS18160
uniprot id: A0A376EXR7
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS14450
gene id: 1074000:AFK65_RS14450
uniprot id: A0A376ESA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1074000:AFK65 RS15385
gene id: 1074000:AFK65_RS15385
uniprot id: A0A376ESY2
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

1074000:AFK65 RS19025
gene id: 1074000:AFK65_RS19025
uniprot id: A0A376F0P2
names: Cofactor
messages: Binds 1 Ca(2+) ion per subunit.

1074000:AFK65 RS03750
gene id: 1074000:AFK65_RS03750
uniprot id: A0A376E325
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

1074000:AFK65 RS07585
gene id: 1074000:AFK65_RS07585
uniprot id: A0A376EA51
names: Similarity
messages: Belongs to the UPF0502 family.

1074000:AFK65 RS14800
gene id: 1074000:AFK65_RS14800
uniprot id: A0A376ER19
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1074000:AFK65 RS10640
gene id: 1074000:AFK65_RS10640
uniprot id: A0A376EG86
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1074000:AFK65 RS15550
gene id: 1074000:AFK65_RS15550
uniprot id: A0A376EUV9
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1074000:AFK65 RS16200
gene id: 1074000:AFK65_RS16200
uniprot id: A0A376EWB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family. ParE type 1 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

1074000:AFK65 RS10965
gene id: 1074000:AFK65_RS10965
uniprot id: A0A376EH93
names: Subcellular Location Annotation
messages: Cytoplasm

1074000:AFK65 RS09120
gene id: 1074000:AFK65_RS09120
uniprot id: A0A376ECB7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1074000:AFK65 RS09020
gene id: 1074000:AFK65_RS09020
uniprot id: A0A376EC37
names: Similarity
messages: Belongs to the GST superfamily.

1074000:AFK65 RS15390
gene id: 1074000:AFK65_RS15390
uniprot id: A0A376EVC1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

1074000:AFK65 RS00715
gene id: 1074000:AFK65_RS00715
uniprot id: A0A376DWU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

1074000:AFK65 RS10535
gene id: 1074000:AFK65_RS10535
uniprot id: A0A376EGQ5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OpgD/OpgG family.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.
messages: Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs).

1074000:AFK65 RS07665
gene id: 1074000:AFK65_RS07665
uniprot id: A0A376E8W9
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Secreted

1074000:AFK65 RS17440
gene id: 1074000:AFK65_RS17440
uniprot id: A0A376EXF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

1074000:AFK65 RS08295
gene id: 1074000:AFK65_RS08295
uniprot id: A0A376EAJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1074000:AFK65 RS10185
gene id: 1074000:AFK65_RS10185
uniprot id: A0A376EH27
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

1074000:AFK65 RS10450
gene id: 1074000:AFK65_RS10450
uniprot id: A0A376EHL3
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1074000:AFK65 RS12880
gene id: 1074000:AFK65_RS12880
uniprot id: A0A376EMX9
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS01010
gene id: 1074000:AFK65_RS01010
uniprot id: A0A376DXE3
names: Similarity
messages: Belongs to the TrbG/VirB9 family.

1074000:AFK65 RS05000
gene id: 1074000:AFK65_RS05000
uniprot id: A0A376E3M5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Cell membrane
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

1074000:AFK65 RS17805
gene id: 1074000:AFK65_RS17805
uniprot id: A0A376EZN7
names: Similarity
messages: Belongs to the DprA/Smf family.

1074000:AFK65 RS14155
gene id: 1074000:AFK65_RS14155
uniprot id: A0A376ESL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CysZ family.
messages: Cell inner membrane
messages: High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway.

1074000:AFK65 RS13495
gene id: 1074000:AFK65_RS13495
uniprot id: A0A376ENT0
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

1074000:AFK65 RS04210
gene id: 1074000:AFK65_RS04210
uniprot id: A0A376E2C1
names: Similarity
messages: Belongs to the YkuD family.

1074000:AFK65 RS14535
gene id: 1074000:AFK65_RS14535
uniprot id: A0A376ERA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M4 family.
messages: Extracellular zinc metalloprotease.
messages: Secreted

1074000:AFK65 RS08570
gene id: 1074000:AFK65_RS08570
uniprot id: A0A376EBT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SufE family.
messages: Cytoplasm
messages: Homodimer. Interacts with SufS.
messages: Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process.

1074000:AFK65 RS17080
gene id: 1074000:AFK65_RS17080
uniprot id: A0A376EZ19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

1074000:AFK65 RS06625
gene id: 1074000:AFK65_RS06625
uniprot id: A0A376E8H3
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

1074000:AFK65 RS18190
gene id: 1074000:AFK65_RS18190
uniprot id: A0A376EZQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Monomer.
messages: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.

1074000:AFK65 RS04605
gene id: 1074000:AFK65_RS04605
uniprot id: A0A376E323
names: Subunit
messages: Homodimer.

1074000:AFK65 RS15650
gene id: 1074000:AFK65_RS15650
uniprot id: A0A376ET12
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS13480
gene id: 1074000:AFK65_RS13480
uniprot id: A0A376ENS5
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the RcsB family.
messages: Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions.
messages: Interacts with RcsD.
messages: Phosphorylated and activated by RcsD.

1074000:AFK65 RS11415
gene id: 1074000:AFK65_RS11415
uniprot id: A0A376EHZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolB family.
messages: Cell outer membrane
messages: Membrane
messages: Monomer.
messages: Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.

1074000:AFK65 RS13275
gene id: 1074000:AFK65_RS13275
uniprot id: A0A376EMJ3
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

1074000:AFK65 RS00570
gene id: 1074000:AFK65_RS00570
uniprot id: A0A376DYN4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Activates expression of the rhaBAD and rhaT operons.
messages: Binds DNA as a dimer.
messages: Cytoplasm

1074000:AFK65 RS16050
gene id: 1074000:AFK65_RS16050
uniprot id: A0A376EXE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS02950
gene id: 1074000:AFK65_RS02950
uniprot id: A0A376E0H7
names: Similarity
messages: Belongs to the OsmC/Ohr family.

1074000:AFK65 RS15660
gene id: 1074000:AFK65_RS15660
uniprot id: A0A376ETR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1074000:AFK65 RS00935
gene id: 1074000:AFK65_RS00935
uniprot id: A0A376DXC6
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1074000:AFK65 RS03720
gene id: 1074000:AFK65_RS03720
uniprot id: A0A376E1I8
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1074000:AFK65 RS10330
gene id: 1074000:AFK65_RS10330
uniprot id: A0A376EFQ7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1074000:AFK65 RS20140
gene id: 1074000:AFK65_RS20140
uniprot id: A0A376KR01
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS11905
gene id: 1074000:AFK65_RS11905
uniprot id: A0A376ELI6
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS19420
gene id: 1074000:AFK65_RS19420
uniprot id: A0A376F1W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1074000:AFK65 RS04485
gene id: 1074000:AFK65_RS04485
uniprot id: A0A376E379
names: Function
names: Similarity
messages: Belongs to the IolE/MocC family.
messages: Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).

1074000:AFK65 RS13365
gene id: 1074000:AFK65_RS13365
uniprot id: A0A376EQN3
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine synthase RsuA family.
messages: Monomer.

1074000:AFK65 RS04505
gene id: 1074000:AFK65_RS04505
uniprot id: A0A376E3C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS03365
gene id: 1074000:AFK65_RS03365
uniprot id: A0A376E0Z3
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1074000:AFK65 RS15015
gene id: 1074000:AFK65_RS15015
uniprot id: A0A376ES60
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

1074000:AFK65 RS19795
gene id: 1074000:AFK65_RS19795
uniprot id: A0A376F007
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1074000:AFK65 RS06965
gene id: 1074000:AFK65_RS06965
uniprot id: A0A376E7K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

1074000:AFK65 RS13625
gene id: 1074000:AFK65_RS13625
uniprot id: A0A376ENB1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1074000:AFK65 RS03235
gene id: 1074000:AFK65_RS03235
uniprot id: A0A376E306
names: Similarity
messages: Belongs to the threonine synthase family.

1074000:AFK65 RS06840
gene id: 1074000:AFK65_RS06840
uniprot id: A0A376E7R4
names: Similarity
names: Subunit
messages: Belongs to the threonine aldolase family.
messages: Homotetramer.

1074000:AFK65 RS01455
gene id: 1074000:AFK65_RS01455
uniprot id: A0A376DY72
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiD family.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
messages: Cell membrane
messages: Homohexamer.

1074000:AFK65 RS05950
gene id: 1074000:AFK65_RS05950
uniprot id: A0A376E5L7
names: Similarity
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.

1074000:AFK65 RS01860
gene id: 1074000:AFK65_RS01860
uniprot id: A0A376DYJ2
names: Similarity
messages: Belongs to the RNase E/G family. RNase G subfamily.

1074000:AFK65 RS00740
gene id: 1074000:AFK65_RS00740
uniprot id: A0A376DYC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1074000:AFK65 RS16670
gene id: 1074000:AFK65_RS16670
uniprot id: A0A376EXX7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

1074000:AFK65 RS09820
gene id: 1074000:AFK65_RS09820
uniprot id: A0A376EFV3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1074000:AFK65 RS09035
gene id: 1074000:AFK65_RS09035
uniprot id: A0A376ED22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1074000:AFK65 RS03265
gene id: 1074000:AFK65_RS03265
uniprot id: A0A376E0Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

1074000:AFK65 RS19730
gene id: 1074000:AFK65_RS19730
uniprot id: A0A376F1R0
names: Similarity
names: Subunit
messages: Belongs to the ViaA family.
messages: Possible formation of a ternary complex RavA-ViaA-CadA.

1074000:AFK65 RS05755
gene id: 1074000:AFK65_RS05755
uniprot id: A0A376E4R0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS12855
gene id: 1074000:AFK65_RS12855
uniprot id: A0A376EMV3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1074000:AFK65 RS17850
gene id: 1074000:AFK65_RS17850
uniprot id: A0A376F061
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1074000:AFK65 RS10945
gene id: 1074000:AFK65_RS10945
uniprot id: A0A376EIU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNR ribonuclease family. RNase II subfamily.
messages: Cytoplasm
messages: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.

1074000:AFK65 RS19895
gene id: 1074000:AFK65_RS19895
uniprot id: A0A376F1X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

1074000:AFK65 RS06545
gene id: 1074000:AFK65_RS06545
uniprot id: A0A376E6L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane
messages: Membrane

1074000:AFK65 RS07650
gene id: 1074000:AFK65_RS07650
uniprot id: A0A376EA94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

1074000:AFK65 RS10575
gene id: 1074000:AFK65_RS10575
uniprot id: A0A376EH42
names: Similarity
messages: Belongs to the FrmR/RcnR family.

1074000:AFK65 RS00050
gene id: 1074000:AFK65_RS00050
uniprot id: A0A376DVV1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate.
messages: Reaction proceeds via an anti dehydration.

1074000:AFK65 RS13980
gene id: 1074000:AFK65_RS13980
uniprot id: A0A376ER64
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS12960
gene id: 1074000:AFK65_RS12960
uniprot id: A0A376ENU5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

1074000:AFK65 RS12085
gene id: 1074000:AFK65_RS12085
uniprot id: A0A376ELY4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

1074000:AFK65 RS16500
gene id: 1074000:AFK65_RS16500
uniprot id: A0A376EX50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

1074000:AFK65 RS09855
gene id: 1074000:AFK65_RS09855
uniprot id: A0A376EEZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS18800
gene id: 1074000:AFK65_RS18800
uniprot id: A0A376F0E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose.
messages: Cell inner membrane

1074000:AFK65 RS03100
gene id: 1074000:AFK65_RS03100
uniprot id: A0A376E0L9
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1074000:AFK65 RS09010
gene id: 1074000:AFK65_RS09010
uniprot id: A0A376EDR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS00105
gene id: 1074000:AFK65_RS00105
uniprot id: A0A376DVN2
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS03805
gene id: 1074000:AFK65_RS03805
uniprot id: A0A376E391
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1074000:AFK65 RS06875
gene id: 1074000:AFK65_RS06875
uniprot id: A0A376E8R7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1074000:AFK65 RS00645
gene id: 1074000:AFK65_RS00645
uniprot id: A0A376DXI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

1074000:AFK65 RS15560
gene id: 1074000:AFK65_RS15560
uniprot id: A0A376EVV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
messages: Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
messages: Cytoplasm
messages: Monomer.

1074000:AFK65 RS05280
gene id: 1074000:AFK65_RS05280
uniprot id: A0A376E5A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Molecular chaperone. Has ATPase activity.

1074000:AFK65 RS12225
gene id: 1074000:AFK65_RS12225
uniprot id: A0A376EMJ4
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1074000:AFK65 RS05585
gene id: 1074000:AFK65_RS05585
uniprot id: A0A376E636
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
messages: Homodimer.

1074000:AFK65 RS13165
gene id: 1074000:AFK65_RS13165
uniprot id: A0A376EMD9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS07320
gene id: 1074000:AFK65_RS07320
uniprot id: A0A376E9I8
names: Function
names: Similarity
messages: Belongs to the non-flavoprotein flavin reductase family. RutF subfamily.
messages: Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway.

1074000:AFK65 RS15940
gene id: 1074000:AFK65_RS15940
uniprot id: A0A376ETW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1074000:AFK65 RS13185
gene id: 1074000:AFK65_RS13185
uniprot id: A0A376EN25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0299 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS02425
gene id: 1074000:AFK65_RS02425
uniprot id: A0A376DZS3
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS07480
gene id: 1074000:AFK65_RS07480
uniprot id: A0A376E9W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CsgC/AgfC family.
messages: Periplasm

1074000:AFK65 RS19180
gene id: 1074000:AFK65_RS19180
uniprot id: A0A376EYL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cdh family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS01415
gene id: 1074000:AFK65_RS01415
uniprot id: A0A376DYX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiJ family.
messages: Cytoplasm
messages: Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.

1074000:AFK65 RS10685
gene id: 1074000:AFK65_RS10685
uniprot id: A0A376EGH9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1074000:AFK65 RS11000
gene id: 1074000:AFK65_RS11000
uniprot id: A0A376EHU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapB family.
messages: Cell inner membrane
messages: Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.

1074000:AFK65 RS05115
gene id: 1074000:AFK65_RS05115
uniprot id: A0A376E5G9
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS14955
gene id: 1074000:AFK65_RS14955
uniprot id: A0A376ETM1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1074000:AFK65 RS03965
gene id: 1074000:AFK65_RS03965
uniprot id: A0A376E2A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

1074000:AFK65 RS05190
gene id: 1074000:AFK65_RS05190
uniprot id: A0A376E4I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

1074000:AFK65 RS13535
gene id: 1074000:AFK65_RS13535
uniprot id: A0A376EQI2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS06370
gene id: 1074000:AFK65_RS06370
uniprot id: A0A376E6R1
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

1074000:AFK65 RS19535
gene id: 1074000:AFK65_RS19535
uniprot id: A0A376EYZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0761 family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS11545
gene id: 1074000:AFK65_RS11545
uniprot id: A0A376EI88
names: Similarity
messages: Belongs to the peptidase S66 family.

1074000:AFK65 RS03450
gene id: 1074000:AFK65_RS03450
uniprot id: A0A376E235
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1074000:AFK65 RS04880
gene id: 1074000:AFK65_RS04880
uniprot id: A0A376E3X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS17720
gene id: 1074000:AFK65_RS17720
uniprot id: A0A376F0P8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS20285
gene id: 1074000:AFK65_RS20285
uniprot id: A0A376KS76
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS12975
gene id: 1074000:AFK65_RS12975
uniprot id: A0A376ELZ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane
messages: Part of a tripartite efflux system composed of MdtA, MdtB and MdtC.

1074000:AFK65 RS04175
gene id: 1074000:AFK65_RS04175
uniprot id: A0A376E398
names: Function
names: Subunit
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.
messages: The DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau.

1074000:AFK65 RS21145
gene id: 1074000:AFK65_RS21145
uniprot id: K8DQU6
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS01265
gene id: 1074000:AFK65_RS01265
uniprot id: A0A376DXR9
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Involved in a late step of protoheme IX synthesis.
messages: Membrane

1074000:AFK65 RS19235
gene id: 1074000:AFK65_RS19235
uniprot id: A0A376EZM4
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

1074000:AFK65 RS12825
gene id: 1074000:AFK65_RS12825
uniprot id: K8DBX5
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1074000:AFK65 RS00640
gene id: 1074000:AFK65_RS00640
uniprot id: A0A376DWV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RraA family.
messages: Cytoplasm
messages: Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome.
messages: Homotrimer. Binds to both RNA-binding sites in the C-terminal region of Rne and to RhlB.

1074000:AFK65 RS06100
gene id: 1074000:AFK65_RS06100
uniprot id: A0A376E801
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: The heme is bound between the two transmembrane subunits.

1074000:AFK65 RS19595
gene id: 1074000:AFK65_RS19595
uniprot id: A0A376F015
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

1074000:AFK65 RS01435
gene id: 1074000:AFK65_RS01435
uniprot id: A0A376DY19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1074000:AFK65 RS01020
gene id: 1074000:AFK65_RS01020
uniprot id: A0A376DXN1
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS12980
gene id: 1074000:AFK65_RS12980
uniprot id: A0A376ENS0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
messages: Cell inner membrane
messages: Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC.

1074000:AFK65 RS13910
gene id: 1074000:AFK65_RS13910
uniprot id: A0A376EQD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
messages: Cytoplasm
messages: Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).

1074000:AFK65 RS15005
gene id: 1074000:AFK65_RS15005
uniprot id: A0A376EUD8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1074000:AFK65 RS17510
gene id: 1074000:AFK65_RS17510
uniprot id: A0A376EYW3
names: Similarity
messages: Belongs to the UPF0047 family.

1074000:AFK65 RS19285
gene id: 1074000:AFK65_RS19285
uniprot id: A0A376EYZ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.

1074000:AFK65 RS06315
gene id: 1074000:AFK65_RS06315
uniprot id: A0A376E600
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

1074000:AFK65 RS07490
gene id: 1074000:AFK65_RS07490
uniprot id: A0A376E8G7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YmdB family.
messages: Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation.
messages: Homodimer. Interacts with RNase III.

1074000:AFK65 RS13810
gene id: 1074000:AFK65_RS13810
uniprot id: A0A376ENT9
names: Function
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.
messages: Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

1074000:AFK65 RS01035
gene id: 1074000:AFK65_RS01035
uniprot id: A0A376DXP3
names: Similarity
messages: Belongs to the TrbE/VirB4 family.

1074000:AFK65 RS02965
gene id: 1074000:AFK65_RS02965
uniprot id: A0A376E1Y8
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

1074000:AFK65 RS09250
gene id: 1074000:AFK65_RS09250
uniprot id: A0A376ECP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

1074000:AFK65 RS12055
gene id: 1074000:AFK65_RS12055
uniprot id: A0A376EMW1
names: Similarity
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.

1074000:AFK65 RS00895
gene id: 1074000:AFK65_RS00895
uniprot id: A0A376DX92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. RhlB subfamily.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

1074000:AFK65 RS11745
gene id: 1074000:AFK65_RS11745
uniprot id: A0A376EJ99
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS14475
gene id: 1074000:AFK65_RS14475
uniprot id: A0A376ER68
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1074000:AFK65 RS06245
gene id: 1074000:AFK65_RS06245
uniprot id: A0A376E5P6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS16150
gene id: 1074000:AFK65_RS16150
uniprot id: A0A376EXB2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.

1074000:AFK65 RS14520
gene id: 1074000:AFK65_RS14520
uniprot id: A0A376ET72
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1074000:AFK65 RS17830
gene id: 1074000:AFK65_RS17830
uniprot id: A0A376F051
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

1074000:AFK65 RS16295
gene id: 1074000:AFK65_RS16295
uniprot id: A0A376EUV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

1074000:AFK65 RS08445
gene id: 1074000:AFK65_RS08445
uniprot id: A0A376EBF0
names: Function
names: Similarity
messages: Belongs to the glutathione peroxidase family. BtuE subfamily.
messages: Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.

1074000:AFK65 RS08670
gene id: 1074000:AFK65_RS08670
uniprot id: A0A376EBF4
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS17595
gene id: 1074000:AFK65_RS17595
uniprot id: A0A376EXS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiC family.
messages: Cytoplasm
messages: Monomer.
messages: Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.

1074000:AFK65 RS02585
gene id: 1074000:AFK65_RS02585
uniprot id: A0A376E1A5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1074000:AFK65 RS11315
gene id: 1074000:AFK65_RS11315
uniprot id: A0A376EHU3
names: Similarity
messages: Belongs to the intimin/invasin family.

1074000:AFK65 RS14860
gene id: 1074000:AFK65_RS14860
uniprot id: A0A376ESK4
names: Function
messages: Acts as a radical domain for damaged PFL and possibly other radical proteins.

1074000:AFK65 RS17085
gene id: 1074000:AFK65_RS17085
uniprot id: A0A376EW32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PriB family.
messages: Binds single-stranded DNA at the primosome assembly site (PAS).
messages: Component of the preprimosomal complex composed of PriA, PriB, PriC, DnaB and DnaT. Upon transient interaction with DnaG it forms the primosome.

1074000:AFK65 RS05865
gene id: 1074000:AFK65_RS05865
uniprot id: A0A376E7F8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

1074000:AFK65 RS08405
gene id: 1074000:AFK65_RS08405
uniprot id: A0A376EAT9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS14470
gene id: 1074000:AFK65_RS14470
uniprot id: A0A376EQS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1074000:AFK65 RS17750
gene id: 1074000:AFK65_RS17750
uniprot id: A0A376EXZ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.

1074000:AFK65 RS12105
gene id: 1074000:AFK65_RS12105
uniprot id: A0A376EMB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane

1074000:AFK65 RS11070
gene id: 1074000:AFK65_RS11070
uniprot id: A0A376EK57
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the anthranilate synthase component I family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

1074000:AFK65 RS05625
gene id: 1074000:AFK65_RS05625
uniprot id: A0A376E519
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Monomer.

1074000:AFK65 RS10360
gene id: 1074000:AFK65_RS10360
uniprot id: A0A376EHR9
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS15165
gene id: 1074000:AFK65_RS15165
uniprot id: A0A376ESL5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1074000:AFK65 RS14565
gene id: 1074000:AFK65_RS14565
uniprot id: A0A376EQJ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS14820
gene id: 1074000:AFK65_RS14820
uniprot id: A0A376ET21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1074000:AFK65 RS04645
gene id: 1074000:AFK65_RS04645
uniprot id: A0A376E339
names: Similarity
messages: Belongs to the complex I 75 kDa subunit family.

1074000:AFK65 RS03270
gene id: 1074000:AFK65_RS03270
uniprot id: A0A376E0V3
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1074000:AFK65 RS02860
gene id: 1074000:AFK65_RS02860
uniprot id: A0A376E0A5
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the porin LamB (TC 1.B.3) family.
messages: By maltose.
messages: Cell outer membrane
messages: Homotrimer formed of three 18-stranded antiparallel beta-barrels, containing three independent channels.
messages: Involved in the transport of maltose and maltodextrins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1074000:AFK65 RS02255
gene id: 1074000:AFK65_RS02255
uniprot id: A0A376DZH7
names: Similarity
messages: Belongs to the UPF0213 family.

1074000:AFK65 RS07880
gene id: 1074000:AFK65_RS07880
uniprot id: A0A376EA23
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides.
messages: Cytoplasm

1074000:AFK65 RS04260
gene id: 1074000:AFK65_RS04260
uniprot id: A0A376E3W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1074000:AFK65 RS01495
gene id: 1074000:AFK65_RS01495
uniprot id: A0A376DY47
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HemG family.
messages: Belongs to the flavodoxin family.
messages: Binds 1 FMN non-covalently per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic conditions uses ubiquinone as an electron acceptor.
messages: Cell membrane

1074000:AFK65 RS09895
gene id: 1074000:AFK65_RS09895
uniprot id: A0A376EF30
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4-oxalocrotonate tautomerase family. PptA subfamily.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS00100
gene id: 1074000:AFK65_RS00100
uniprot id: A0A376DX21
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

1074000:AFK65 RS00595
gene id: 1074000:AFK65_RS00595
uniprot id: A0A376DYP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
messages: Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.
messages: Cell membrane

1074000:AFK65 RS08575
gene id: 1074000:AFK65_RS08575
uniprot id: A0A376ECU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YkuD family.
messages: Periplasm

1074000:AFK65 RS08640
gene id: 1074000:AFK65_RS08640
uniprot id: A0A376EEC2
names: Similarity
messages: Belongs to the HypD family.

1074000:AFK65 RS07220
gene id: 1074000:AFK65_RS07220
uniprot id: A0A376E9J3
names: Subcellular Location Annotation
messages: Cell inner membrane

1074000:AFK65 RS03220
gene id: 1074000:AFK65_RS03220
uniprot id: A0A376E136
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS04650
gene id: 1074000:AFK65_RS04650
uniprot id: A0A376E3G3
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS07625
gene id: 1074000:AFK65_RS07625
uniprot id: A0A376EAA9
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

1074000:AFK65 RS11795
gene id: 1074000:AFK65_RS11795
uniprot id: A0A376EJQ7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS07135
gene id: 1074000:AFK65_RS07135
uniprot id: A0A376E7U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein SsuA/TauA family.
messages: Periplasm

1074000:AFK65 RS13600
gene id: 1074000:AFK65_RS13600
uniprot id: A0A376EQS0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family. RNase BN subfamily.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which has both exoribonuclease and endoribonuclease activities.

1074000:AFK65 RS12510
gene id: 1074000:AFK65_RS12510
uniprot id: A0A376EKW8
names: Similarity
messages: Belongs to the DsrB family.

1074000:AFK65 RS06950
gene id: 1074000:AFK65_RS06950
uniprot id: A0A376E7J7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. YcaD (TC 2.A.1.26) family.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1074000:AFK65 RS02345
gene id: 1074000:AFK65_RS02345
uniprot id: A0A376DZJ5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS07385
gene id: 1074000:AFK65_RS07385
uniprot id: A0A376E9P0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DyP-type peroxidase family. EfeB subfamily.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.
messages: Homodimer. Part of a ferrous iron transporter composed of EfeU, EfeO and EfeB.
messages: Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.
messages: Periplasm

1074000:AFK65 RS15900
gene id: 1074000:AFK65_RS15900
uniprot id: A0A376ETS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-modifying YgfZ family.
messages: Cytoplasm
messages: Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication.

1074000:AFK65 RS13965
gene id: 1074000:AFK65_RS13965
uniprot id: A0A376ER53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

1074000:AFK65 RS13695
gene id: 1074000:AFK65_RS13695
uniprot id: A0A376EQY4
names: Similarity
messages: Belongs to the UPF0304 family.

1074000:AFK65 RS03875
gene id: 1074000:AFK65_RS03875
uniprot id: A0A376E447
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS00705
gene id: 1074000:AFK65_RS00705
uniprot id: A0A376DWQ7
names: Similarity
messages: Belongs to the MQO family.

1074000:AFK65 RS06730
gene id: 1074000:AFK65_RS06730
uniprot id: A0A376E7J3
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

1074000:AFK65 RS19915
gene id: 1074000:AFK65_RS19915
uniprot id: A0A376F1Q4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

1074000:AFK65 RS20145
gene id: 1074000:AFK65_RS20145
uniprot id: A0A376KPZ9
names: Similarity
messages: Belongs to the SIP oxidoreductase family.

1074000:AFK65 RS17575
gene id: 1074000:AFK65_RS17575
uniprot id: A0A376EZB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

1074000:AFK65 RS07610
gene id: 1074000:AFK65_RS07610
uniprot id: A0A376EA69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FlgA family.
messages: Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
messages: Periplasm

1074000:AFK65 RS16470
gene id: 1074000:AFK65_RS16470
uniprot id: A0A376EX29
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS07615
gene id: 1074000:AFK65_RS07615
uniprot id: A0A376E9I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

1074000:AFK65 RS18695
gene id: 1074000:AFK65_RS18695
uniprot id: A0A376EYD4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1074000:AFK65 RS16030
gene id: 1074000:AFK65_RS16030
uniprot id: A0A376EXC0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1074000:AFK65 RS01290
gene id: 1074000:AFK65_RS01290
uniprot id: A0A376DXT1
names: Function
names: Similarity
messages: Belongs to the frataxin family.
messages: Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.

1074000:AFK65 RS17185
gene id: 1074000:AFK65_RS17185
uniprot id: A0A376EYR9
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1074000:AFK65 RS06660
gene id: 1074000:AFK65_RS06660
uniprot id: A0A376E6V0
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS00790
gene id: 1074000:AFK65_RS00790
uniprot id: A0A376DX20
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1074000:AFK65 RS03580
gene id: 1074000:AFK65_RS03580
uniprot id: A0A376E1C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1074000:AFK65 RS17145
gene id: 1074000:AFK65_RS17145
uniprot id: A0A376EYP1
names: Cofactor
names: Function
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity.

1074000:AFK65 RS13730
gene id: 1074000:AFK65_RS13730
uniprot id: A0A376ER37
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1074000:AFK65 RS08890
gene id: 1074000:AFK65_RS08890
uniprot id: A0A376EBW3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

1074000:AFK65 RS02535
gene id: 1074000:AFK65_RS02535
uniprot id: A0A376DZP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1074000:AFK65 RS11780
gene id: 1074000:AFK65_RS11780
uniprot id: A0A376EKI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MgrB family.
messages: Cell membrane
messages: May form homooligomers. Probably interacts with the periplasmic domain of PhoQ.
messages: PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing. MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway. Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP.

1074000:AFK65 RS14525
gene id: 1074000:AFK65_RS14525
uniprot id: A0A376EQW5
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1074000:AFK65 RS05665
gene id: 1074000:AFK65_RS05665
uniprot id: A0A376E5S7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1074000:AFK65 RS10495
gene id: 1074000:AFK65_RS10495
uniprot id: A0A376EHM7
names: Similarity
messages: Belongs to the peptidase S24 family.

1074000:AFK65 RS03170
gene id: 1074000:AFK65_RS03170
uniprot id: A0A376E0X8
names: Similarity
messages: Belongs to the transglycosylase Slt family.

1074000:AFK65 RS16870
gene id: 1074000:AFK65_RS16870
uniprot id: A0A376EXS4
names: Similarity
messages: Belongs to the UPF0307 family.

1074000:AFK65 RS06310
gene id: 1074000:AFK65_RS06310
uniprot id: A0A376E6J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS18035
gene id: 1074000:AFK65_RS18035
uniprot id: A0A376F108
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1074000:AFK65 RS19230
gene id: 1074000:AFK65_RS19230
uniprot id: A0A376F2E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

1074000:AFK65 RS03115
gene id: 1074000:AFK65_RS03115
uniprot id: A0A376E2B2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS14360
gene id: 1074000:AFK65_RS14360
uniprot id: A0A376ESF9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

1074000:AFK65 RS21570
gene id: 1074000:AFK65_RS21570
uniprot id: A0A376EQ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0387 family.
messages: Cell membrane

1074000:AFK65 RS02135
gene id: 1074000:AFK65_RS02135
uniprot id: A0A376E0K4
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1074000:AFK65 RS18265
gene id: 1074000:AFK65_RS18265
uniprot id: A0A376EXV1
names: Similarity
messages: Belongs to the HSP15 family.

1074000:AFK65 RS12490
gene id: 1074000:AFK65_RS12490
uniprot id: A0A376EKY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

1074000:AFK65 RS10645
gene id: 1074000:AFK65_RS10645
uniprot id: A0A376EH78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane
messages: Membrane

1074000:AFK65 RS04200
gene id: 1074000:AFK65_RS04200
uniprot id: A0A376E2J6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: Homotetramer.
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

1074000:AFK65 RS13765
gene id: 1074000:AFK65_RS13765
uniprot id: A0A376EQK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS03975
gene id: 1074000:AFK65_RS03975
uniprot id: A0A376E226
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.

1074000:AFK65 RS11050
gene id: 1074000:AFK65_RS11050
uniprot id: A0A376EK37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cob(I)alamin adenosyltransferase family.
messages: Cytoplasm
messages: Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.

1074000:AFK65 RS07865
gene id: 1074000:AFK65_RS07865
uniprot id: A0A376EA17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS06855
gene id: 1074000:AFK65_RS06855
uniprot id: A0A376E776
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

1074000:AFK65 RS15080
gene id: 1074000:AFK65_RS15080
uniprot id: A0A376ETL0
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS02410
gene id: 1074000:AFK65_RS02410
uniprot id: A0A376DZK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MzrA family.
messages: Cell inner membrane
messages: Interacts with EnvZ.
messages: Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR.

1074000:AFK65 RS04420
gene id: 1074000:AFK65_RS04420
uniprot id: A0A376E3U1
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Binds 1 sodium ion per monomer.
messages: Binds 2 magnesium ions per monomer.
messages: Homotetramer.

1074000:AFK65 RS15420
gene id: 1074000:AFK65_RS15420
uniprot id: A0A376EUI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PAPS reductase family. CysD subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

1074000:AFK65 RS01530
gene id: 1074000:AFK65_RS01530
uniprot id: A0A376DY56
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
messages: Belongs to the biotin--protein ligase family.

1074000:AFK65 RS12015
gene id: 1074000:AFK65_RS12015
uniprot id: A0A376ELU2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CutC family.
messages: Cytoplasm
messages: Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.

1074000:AFK65 RS02625
gene id: 1074000:AFK65_RS02625
uniprot id: A0A376E1Z9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1074000:AFK65 RS16610
gene id: 1074000:AFK65_RS16610
uniprot id: A0A376EW41
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

1074000:AFK65 RS01775
gene id: 1074000:AFK65_RS01775
uniprot id: A0A376DYE9
names: Function
names: Similarity
names: Subunit
messages: Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters.
messages: Belongs to the transcriptional regulatory Fis family.
messages: Homodimer.

1074000:AFK65 RS14775
gene id: 1074000:AFK65_RS14775
uniprot id: A0A376EQZ9
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Induced by MurNAc 6-phosphate that releases the repressor MurR from the DNA. Repressed by MurR in the absence of MurNAc 6-phosphate.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

1074000:AFK65 RS04765
gene id: 1074000:AFK65_RS04765
uniprot id: A0A376E363
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1074000:AFK65 RS20220
gene id: 1074000:AFK65_RS20220
uniprot id: A0A376KQ36
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1074000:AFK65 RS11180
gene id: 1074000:AFK65_RS11180
uniprot id: A0A376EHJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

1074000:AFK65 RS16580
gene id: 1074000:AFK65_RS16580
uniprot id: A0A376EXI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CitD family.
messages: Covalent carrier of the coenzyme of citrate lyase.
messages: Cytoplasm
messages: Oligomer with a subunit composition of (alpha,beta,gamma)6.

1074000:AFK65 RS14180
gene id: 1074000:AFK65_RS14180
uniprot id: A0A376EPN4
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1074000:AFK65 RS04425
gene id: 1074000:AFK65_RS04425
uniprot id: A0A376E4C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Oligosaccharide:H(+) symporter (OHS) (TC 2.A.1.5) family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS00690
gene id: 1074000:AFK65_RS00690
uniprot id: A0A376DXL9
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

1074000:AFK65 RS08915
gene id: 1074000:AFK65_RS08915
uniprot id: A0A376EBY8
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS00625
gene id: 1074000:AFK65_RS00625
uniprot id: A0A376DY12
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activity of this regulatory enzyme is affected by several metabolites. Allosterically and non-competitively inhibited by fructose 1,6-bisphosphate (FBP) and unphosphorylated phosphocarrier protein EIIA-Glc (III-Glc), an integral component of the bacterial phosphotransferase (PTS) system.
messages: Belongs to the FGGY kinase family.
messages: Homotetramer and homodimer (in equilibrium). Heterodimer with EIIA-Glc. Binds 1 zinc ion per glycerol kinase EIIA-Glc dimer. The zinc ion is important for dimerization.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

1074000:AFK65 RS19970
gene id: 1074000:AFK65_RS19970
uniprot id: A0A376KRW6
names: Similarity
messages: Belongs to the darcynin family.

1074000:AFK65 RS05380
gene id: 1074000:AFK65_RS05380
uniprot id: A0A376E4N6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1074000:AFK65 RS06955
gene id: 1074000:AFK65_RS06955
uniprot id: A0A376EA83
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

1074000:AFK65 RS12995
gene id: 1074000:AFK65_RS12995
uniprot id: A0A376EM03
names: Subcellular Location Annotation
messages: Cell inner membrane

1074000:AFK65 RS05660
gene id: 1074000:AFK65_RS05660
uniprot id: A0A376E4Y9
names: Similarity
messages: Belongs to the universal stress protein A family.

1074000:AFK65 RS03325
gene id: 1074000:AFK65_RS03325
uniprot id: A0A376E179
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1074000:AFK65 RS00945
gene id: 1074000:AFK65_RS00945
uniprot id: A0A376DY68
names: Function
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.
messages: Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D-galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D-Glc4O) and L-glutamate.

1074000:AFK65 RS12090
gene id: 1074000:AFK65_RS12090
uniprot id: A0A376EKU5
names: Function
messages: Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.

1074000:AFK65 RS07015
gene id: 1074000:AFK65_RS07015
uniprot id: A0A376E814
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS03655
gene id: 1074000:AFK65_RS03655
uniprot id: A0A376E2X4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

1074000:AFK65 RS12220
gene id: 1074000:AFK65_RS12220
uniprot id: A0A376ELI4
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS11725
gene id: 1074000:AFK65_RS11725
uniprot id: A0A376EJ78
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS00845
gene id: 1074000:AFK65_RS00845
uniprot id: A0A376DYJ4
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1074000:AFK65 RS03060
gene id: 1074000:AFK65_RS03060
uniprot id: A0A376E236
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1074000:AFK65 RS11755
gene id: 1074000:AFK65_RS11755
uniprot id: A0A376EIP4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably functions as a manganese efflux pump.

1074000:AFK65 RS16095
gene id: 1074000:AFK65_RS16095
uniprot id: A0A376EWE0
names: Similarity
messages: Belongs to the GSP E family.

1074000:AFK65 RS18870
gene id: 1074000:AFK65_RS18870
uniprot id: A0A376F231
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS19155
gene id: 1074000:AFK65_RS19155
uniprot id: A0A376EYK6
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Member of a two-component regulatory system.

1074000:AFK65 RS04430
gene id: 1074000:AFK65_RS04430
uniprot id: A0A376E3V2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.
messages: Homotetramer.

1074000:AFK65 RS18280
gene id: 1074000:AFK65_RS18280
uniprot id: A0A376EXP3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Monomer.

1074000:AFK65 RS16755
gene id: 1074000:AFK65_RS16755
uniprot id: A0A376EXK8
names: Subunit
messages: Monomer.

1074000:AFK65 RS01885
gene id: 1074000:AFK65_RS01885
uniprot id: A0A376DYK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell membrane
messages: Forms an efflux pump with AaeB.

1074000:AFK65 RS07245
gene id: 1074000:AFK65_RS07245
uniprot id: A0A376E902
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmI family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.

1074000:AFK65 RS15565
gene id: 1074000:AFK65_RS15565
uniprot id: A0A376EUD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

1074000:AFK65 RS05780
gene id: 1074000:AFK65_RS05780
uniprot id: A0A376E589
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

1074000:AFK65 RS20335
gene id: 1074000:AFK65_RS20335
uniprot id: A0A376KS98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.

1074000:AFK65 RS17380
gene id: 1074000:AFK65_RS17380
uniprot id: A0A376EYP6
names: Similarity
messages: Belongs to the YjdM family.

1074000:AFK65 RS10605
gene id: 1074000:AFK65_RS10605
uniprot id: A0A376EG80
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1074000:AFK65 RS07105
gene id: 1074000:AFK65_RS07105
uniprot id: A0A376E9M7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS01310
gene id: 1074000:AFK65_RS01310
uniprot id: A0A376DXV9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD, in which XerC interacts with XerD via its C-terminal region, XerD interacts with XerC via its C-terminal region and so on.
messages: FtsK may regulate the catalytic switch between XerC and XerD in the heterotetrameric complex during the two steps of the recombination process.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerC specifically exchanges the top DNA strands.

1074000:AFK65 RS19370
gene id: 1074000:AFK65_RS19370
uniprot id: A0A376F1U9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1074000:AFK65 RS11955
gene id: 1074000:AFK65_RS11955
uniprot id: A0A376EK05
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1074000:AFK65 RS07345
gene id: 1074000:AFK65_RS07345
uniprot id: A0A376E965
names: Function
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family. RutA subfamily.
messages: Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism, adding oxygen atoms in the process to yield ureidoacrylate peracid, that immediately reacts with FMN forming ureidoacrylate and FMN-N(5)-oxide. The FMN-N(5)-oxide reacts spontaneously with NADH to produce FMN. Requires the flavin reductase RutF to regenerate FMN in vivo.

1074000:AFK65 RS09095
gene id: 1074000:AFK65_RS09095
uniprot id: A0A376EDY8
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS18840
gene id: 1074000:AFK65_RS18840
uniprot id: A0A376F220
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS11940
gene id: 1074000:AFK65_RS11940
uniprot id: A0A376ELW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS06220
gene id: 1074000:AFK65_RS06220
uniprot id: A0A376E5L8
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS18740
gene id: 1074000:AFK65_RS18740
uniprot id: A0A376F0M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS19440
gene id: 1074000:AFK65_RS19440
uniprot id: A0A376F157
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

1074000:AFK65 RS03095
gene id: 1074000:AFK65_RS03095
uniprot id: A0A376E2T8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1074000:AFK65 RS16790
gene id: 1074000:AFK65_RS16790
uniprot id: A0A376EYK8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1074000:AFK65 RS19765
gene id: 1074000:AFK65_RS19765
uniprot id: A0A376F1D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1074000:AFK65 RS10725
gene id: 1074000:AFK65_RS10725
uniprot id: A0A376EGE9
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1074000:AFK65 RS04945
gene id: 1074000:AFK65_RS04945
uniprot id: A0A376E3G7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1074000:AFK65 RS02225
gene id: 1074000:AFK65_RS02225
uniprot id: A0A376DZ63
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.
messages: Cell inner membrane
messages: Involved in transporting aromatic amino acids across the cytoplasmic membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1074000:AFK65 RS03800
gene id: 1074000:AFK65_RS03800
uniprot id: A0A376E1Q3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1074000:AFK65 RS06120
gene id: 1074000:AFK65_RS06120
uniprot id: A0A376E5E2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

1074000:AFK65 RS12495
gene id: 1074000:AFK65_RS12495
uniprot id: A0A376EN30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Required for the assembly of the rivet at the earliest stage of flagellar biosynthesis.
messages: Role in flagellar biosynthesis.

1074000:AFK65 RS19785
gene id: 1074000:AFK65_RS19785
uniprot id: A0A376EZH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1074000:AFK65 RS04910
gene id: 1074000:AFK65_RS04910
uniprot id: A0A376E552
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

1074000:AFK65 RS17335
gene id: 1074000:AFK65_RS17335
uniprot id: A0A376EWK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.

1074000:AFK65 RS14635
gene id: 1074000:AFK65_RS14635
uniprot id: A0A376ETQ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Probably plays an important role in intracellular peptide degradation.

1074000:AFK65 RS11025
gene id: 1074000:AFK65_RS11025
uniprot id: A0A376EJ11
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS16810
gene id: 1074000:AFK65_RS16810
uniprot id: A0A376EVN4
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

1074000:AFK65 RS00020
gene id: 1074000:AFK65_RS00020
uniprot id: A0A376DVI3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1074000:AFK65 RS19620
gene id: 1074000:AFK65_RS19620
uniprot id: A0A376F1D0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1074000:AFK65 RS08270
gene id: 1074000:AFK65_RS08270
uniprot id: A0A376EAF7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Transforms N(2)-succinylglutamate into succinate and glutamate.

1074000:AFK65 RS02920
gene id: 1074000:AFK65_RS02920
uniprot id: A0A376E1D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane

1074000:AFK65 RS05485
gene id: 1074000:AFK65_RS05485
uniprot id: A0A376E6T2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS09070
gene id: 1074000:AFK65_RS09070
uniprot id: A0A376ECB8
names: Similarity
messages: Belongs to the Hha/YmoA/Cnu family.

1074000:AFK65 RS14195
gene id: 1074000:AFK65_RS14195
uniprot id: A0A376EQ25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

1074000:AFK65 RS13700
gene id: 1074000:AFK65_RS13700
uniprot id: A0A376ER06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0208 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS08465
gene id: 1074000:AFK65_RS08465
uniprot id: A0A376EDV0
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

1074000:AFK65 RS03130
gene id: 1074000:AFK65_RS03130
uniprot id: A0A376E0P9
names: Similarity
messages: Belongs to the stealth family.

1074000:AFK65 RS09915
gene id: 1074000:AFK65_RS09915
uniprot id: A0A376EG61
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1074000:AFK65 RS15820
gene id: 1074000:AFK65_RS15820
uniprot id: A0A376EV54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

1074000:AFK65 RS05445
gene id: 1074000:AFK65_RS05445
uniprot id: A0A376E4R2
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS14025
gene id: 1074000:AFK65_RS14025
uniprot id: A0A376ERB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

1074000:AFK65 RS08210
gene id: 1074000:AFK65_RS08210
uniprot id: A0A376EAA8
names: Similarity
messages: Belongs to the asparaginase 1 family.

1074000:AFK65 RS15020
gene id: 1074000:AFK65_RS15020
uniprot id: A0A376ETF3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1074000:AFK65 RS03225
gene id: 1074000:AFK65_RS03225
uniprot id: A0A376E2B4
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

1074000:AFK65 RS13620
gene id: 1074000:AFK65_RS13620
uniprot id: A0A376EQ68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1074000:AFK65 RS15150
gene id: 1074000:AFK65_RS15150
uniprot id: A0A376EUT4
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

1074000:AFK65 RS01300
gene id: 1074000:AFK65_RS01300
uniprot id: A0A376DXT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS13210
gene id: 1074000:AFK65_RS13210
uniprot id: A0A376EPT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and/or methyl galactoside import. Responsible for energy coupling to the transport system.

1074000:AFK65 RS19010
gene id: 1074000:AFK65_RS19010
uniprot id: A0A376EZ74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane.

1074000:AFK65 RS03595
gene id: 1074000:AFK65_RS03595
uniprot id: A0A376E1E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

1074000:AFK65 RS11255
gene id: 1074000:AFK65_RS11255
uniprot id: A0A376EHT7
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS16735
gene id: 1074000:AFK65_RS16735
uniprot id: A0A376EVR2
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1074000:AFK65 RS17675
gene id: 1074000:AFK65_RS17675
uniprot id: A0A376EZ52
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

1074000:AFK65 RS00930
gene id: 1074000:AFK65_RS00930
uniprot id: A0A376DY58
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

1074000:AFK65 RS04920
gene id: 1074000:AFK65_RS04920
uniprot id: A0A376E5W7
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

1074000:AFK65 RS17955
gene id: 1074000:AFK65_RS17955
uniprot id: A0A376EY09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1074000:AFK65 RS17235
gene id: 1074000:AFK65_RS17235
uniprot id: A0A376EX53
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

1074000:AFK65 RS18670
gene id: 1074000:AFK65_RS18670
uniprot id: A0A376EYC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein B family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS01365
gene id: 1074000:AFK65_RS01365
uniprot id: A0A376DXY8
names: Similarity
messages: Belongs to the Rht family.

1074000:AFK65 RS06600
gene id: 1074000:AFK65_RS06600
uniprot id: A0A376E999
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS17045
gene id: 1074000:AFK65_RS17045
uniprot id: A0A376EWP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS00575
gene id: 1074000:AFK65_RS00575
uniprot id: A0A376DY15
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Activates expression of the rhaSR operon in response to L-rhamnose.
messages: Binds DNA as a dimer.
messages: Cytoplasm

1074000:AFK65 RS01480
gene id: 1074000:AFK65_RS01480
uniprot id: A0A376DZ09
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Splits dipeptides with a prolyl residue in the C-terminal position.

1074000:AFK65 RS12180
gene id: 1074000:AFK65_RS12180
uniprot id: A0A376EM65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Periplasm

1074000:AFK65 RS11325
gene id: 1074000:AFK65_RS11325
uniprot id: A0A376EIG9
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.

1074000:AFK65 RS16035
gene id: 1074000:AFK65_RS16035
uniprot id: A0A376EVR9
names: Function
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.
messages: Catalyzes the formation of putrescine from agmatine.

1074000:AFK65 RS00490
gene id: 1074000:AFK65_RS00490
uniprot id: A0A376DWG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

1074000:AFK65 RS00055
gene id: 1074000:AFK65_RS00055
uniprot id: A0A376DWG8
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS08245
gene id: 1074000:AFK65_RS08245
uniprot id: A0A376EAB1
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1074000:AFK65 RS03585
gene id: 1074000:AFK65_RS03585
uniprot id: A0A376E3I3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. FtsW subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell division.

1074000:AFK65 RS06720
gene id: 1074000:AFK65_RS06720
uniprot id: A0A376E7D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAE transporter (TC 2.A.81) family. YbjL subfamily.
messages: Cell membrane

1074000:AFK65 RS03085
gene id: 1074000:AFK65_RS03085
uniprot id: A0A376E1L2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LplA family.
messages: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
messages: Cytoplasm
messages: In the transfer reaction, the free carboxyl group of lipoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
messages: Monomer.

1074000:AFK65 RS14150
gene id: 1074000:AFK65_RS14150
uniprot id: A0A376EPL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZipA family.
messages: Cell inner membrane
messages: Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.
messages: Interacts with FtsZ via their C-terminal domains.

1074000:AFK65 RS05200
gene id: 1074000:AFK65_RS05200
uniprot id: A0A376E5N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1074000:AFK65 RS02600
gene id: 1074000:AFK65_RS02600
uniprot id: A0A376E032
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

1074000:AFK65 RS03550
gene id: 1074000:AFK65_RS03550
uniprot id: A0A376E181
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1074000:AFK65 RS07725
gene id: 1074000:AFK65_RS07725
uniprot id: A0A376E924
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

1074000:AFK65 RS03700
gene id: 1074000:AFK65_RS03700
uniprot id: A0A376E2Z2
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS14260
gene id: 1074000:AFK65_RS14260
uniprot id: A0A376ER82
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS00045
gene id: 1074000:AFK65_RS00045
uniprot id: A0A376DVL6
names: Similarity
names: Subunit
messages: Belongs to the KHG/KDPG aldolase family.
messages: Homotrimer.

1074000:AFK65 RS10740
gene id: 1074000:AFK65_RS10740
uniprot id: A0A376EHE8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.
messages: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
messages: Cytoplasm
messages: Homodimer.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

1074000:AFK65 RS18490
gene id: 1074000:AFK65_RS18490
uniprot id: A0A376EY46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS15255
gene id: 1074000:AFK65_RS15255
uniprot id: A0A376EU33
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm
messages: Homotetramer.

1074000:AFK65 RS18315
gene id: 1074000:AFK65_RS18315
uniprot id: A0A376EXX1
names: Function
names: Similarity
messages: Belongs to the FeoC family.
messages: May function as a transcriptional regulator that controls feoABC expression.

1074000:AFK65 RS13795
gene id: 1074000:AFK65_RS13795
uniprot id: A0A376EQN8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS11605
gene id: 1074000:AFK65_RS11605
uniprot id: A0A376EI90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein.

1074000:AFK65 RS07720
gene id: 1074000:AFK65_RS07720
uniprot id: A0A376EAH9
names: Similarity
messages: Belongs to the fabD family.

1074000:AFK65 RS03020
gene id: 1074000:AFK65_RS03020
uniprot id: A0A376E0I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. RsmC family.
messages: Cytoplasm
messages: Monomer.
messages: Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.

1074000:AFK65 RS11680
gene id: 1074000:AFK65_RS11680
uniprot id: A0A376EIC7
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS09245
gene id: 1074000:AFK65_RS09245
uniprot id: A0A376ECN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS02525
gene id: 1074000:AFK65_RS02525
uniprot id: A0A376DZN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

1074000:AFK65 RS07230
gene id: 1074000:AFK65_RS07230
uniprot id: A0A376E8N0
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

1074000:AFK65 RS16880
gene id: 1074000:AFK65_RS16880
uniprot id: A0A376EY18
names: Function
names: Similarity
messages: Belongs to the MurCDEF family. Mpl subfamily.
messages: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.

1074000:AFK65 RS18845
gene id: 1074000:AFK65_RS18845
uniprot id: A0A376EZ88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS10745
gene id: 1074000:AFK65_RS10745
uniprot id: A0A376EIA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Cell inner membrane
messages: Membrane
messages: Zinc transporter. Acts as a Zn(2+):proton symporter, which likely mediates zinc ion uptake.

1074000:AFK65 RS15920
gene id: 1074000:AFK65_RS15920
uniprot id: A0A376EVE8
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1074000:AFK65 RS11920
gene id: 1074000:AFK65_RS11920
uniprot id: A0A376EKU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily.
messages: Catalyzes the transfer of an acyl chain from an acyl-[acyl-carrier-protein] (ACP) to a Kdo(2)-(acyl)-lipid IV(A) to form a Kdo(2)-lipid A.
messages: Cell inner membrane

1074000:AFK65 RS11635
gene id: 1074000:AFK65_RS11635
uniprot id: A0A376EJ98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

1074000:AFK65 RS06845
gene id: 1074000:AFK65_RS06845
uniprot id: A0A376E8P7
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A peripheral cell membrane enzyme that catalyzes the oxidative decarboxylation of pyruvate to form acetate and CO(2). It channels electrons from the cytoplasm to the respiratory chain at the cell membrane via ubiquinone.
messages: Belongs to the TPP enzyme family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Cell membrane
messages: Has 4 domains; the Pyr domain which binds the pyrimidine moiety of the thiamine pyrophosphate cofactor, the FAD-binding domain, the PP-binding domain which binds the pyrophosphate portion of thiamine pyrophosphate and the C-terminal membrane binding region. The C-terminus is held closely against the rest of the protein and covers the active site; during activation it unfolds from the rest of the protein and forms an amphipathic helix upon membrane binding, exposing the active site.
messages: Homotetramer.
messages: The C-terminus inhibits activity; it has to move for the enzyme to be active. Activated by lipid-binding, which occurs via the C-terminus.

1074000:AFK65 RS07925
gene id: 1074000:AFK65_RS07925
uniprot id: A0A376E9E8
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1074000:AFK65 RS06750
gene id: 1074000:AFK65_RS06750
uniprot id: A0A376E6Y5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

1074000:AFK65 RS04955
gene id: 1074000:AFK65_RS04955
uniprot id: A0A376E3Z2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS16915
gene id: 1074000:AFK65_RS16915
uniprot id: A0A376EY39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1074000:AFK65 RS08585
gene id: 1074000:AFK65_RS08585
uniprot id: A0A376EBU5
names: Similarity
messages: Belongs to the pyruvate kinase family.

1074000:AFK65 RS15800
gene id: 1074000:AFK65_RS15800
uniprot id: A0A376ETG0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1074000:AFK65 RS17150
gene id: 1074000:AFK65_RS17150
uniprot id: A0A376EYH5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1074000:AFK65 RS09025
gene id: 1074000:AFK65_RS09025
uniprot id: A0A376EC61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Proton-dependent permease that transports di- and tripeptides.

1074000:AFK65 RS14200
gene id: 1074000:AFK65_RS14200
uniprot id: A0A376ER25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

1074000:AFK65 RS02085
gene id: 1074000:AFK65_RS02085
uniprot id: A0A376DYV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

1074000:AFK65 RS14330
gene id: 1074000:AFK65_RS14330
uniprot id: A0A376EQT3
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS14865
gene id: 1074000:AFK65_RS14865
uniprot id: A0A376EU43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1074000:AFK65 RS11915
gene id: 1074000:AFK65_RS11915
uniprot id: A0A376ELU4
names: Similarity
messages: Belongs to the pyruvate kinase family.

1074000:AFK65 RS15620
gene id: 1074000:AFK65_RS15620
uniprot id: A0A376ESY4
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
messages: Belongs to the RecD family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

1074000:AFK65 RS19455
gene id: 1074000:AFK65_RS19455
uniprot id: A0A376F1G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

1074000:AFK65 RS00555
gene id: 1074000:AFK65_RS00555
uniprot id: A0A376DWH0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. RhaD subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
messages: Cytoplasm
messages: Homotetramer.

1074000:AFK65 RS18875
gene id: 1074000:AFK65_RS18875
uniprot id: A0A376EZ97
names: Similarity
messages: Belongs to the OsmC/Ohr family.

1074000:AFK65 RS07655
gene id: 1074000:AFK65_RS07655
uniprot id: A0A376E9J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.
messages: In the C-terminal section; belongs to the glycosyl hydrolase 73 family.
messages: In the N-terminal section; belongs to the FlgJ family.
messages: Periplasm

1074000:AFK65 RS10475
gene id: 1074000:AFK65_RS10475
uniprot id: A0A376EHY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS04510
gene id: 1074000:AFK65_RS04510
uniprot id: A0A376E399
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

1074000:AFK65 RS16155
gene id: 1074000:AFK65_RS16155
uniprot id: A0A376EWK9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS00750
gene id: 1074000:AFK65_RS00750
uniprot id: A0A376DZ05
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS12750
gene id: 1074000:AFK65_RS12750
uniprot id: A0A376EML3
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1074000:AFK65 RS17935
gene id: 1074000:AFK65_RS17935
uniprot id: A0A376F0W6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1074000:AFK65 RS18675
gene id: 1074000:AFK65_RS18675
uniprot id: A0A376F0A1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm
messages: Required for resistance to DNA-damaging agents.

1074000:AFK65 RS00885
gene id: 1074000:AFK65_RS00885
uniprot id: A0A376DXF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. UvrD subfamily.
messages: Homodimer.
messages: Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.

1074000:AFK65 RS13025
gene id: 1074000:AFK65_RS13025
uniprot id: A0A376EPE0
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

1074000:AFK65 RS00440
gene id: 1074000:AFK65_RS00440
uniprot id: A0A376DWL8
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Homodimer.
messages: Membrane

1074000:AFK65 RS14640
gene id: 1074000:AFK65_RS14640
uniprot id: A0A376ETF6
names: Function
names: Similarity
messages: Belongs to the IscX family.
messages: May function as iron donor in the assembly of iron-sulfur clusters.

1074000:AFK65 RS01575
gene id: 1074000:AFK65_RS01575
uniprot id: A0A376DYA9
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1074000:AFK65 RS07535
gene id: 1074000:AFK65_RS07535
uniprot id: A0A376EBD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0312 family. Type 1 subfamily.
messages: Periplasm

1074000:AFK65 RS19810
gene id: 1074000:AFK65_RS19810
uniprot id: A0A376F094
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

1074000:AFK65 RS18310
gene id: 1074000:AFK65_RS18310
uniprot id: A0A376F044
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

1074000:AFK65 RS00060
gene id: 1074000:AFK65_RS00060
uniprot id: A0A376DVK3
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS05315
gene id: 1074000:AFK65_RS05315
uniprot id: A0A376E4K8
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.

1074000:AFK65 RS05965
gene id: 1074000:AFK65_RS05965
uniprot id: A0A376E5R1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS01935
gene id: 1074000:AFK65_RS01935
uniprot id: A0A376E096
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZapG family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS04080
gene id: 1074000:AFK65_RS04080
uniprot id: A0A376E2F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RcsF family.
messages: Cell outer membrane
messages: Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects.

1074000:AFK65 RS06345
gene id: 1074000:AFK65_RS06345
uniprot id: A0A376E6U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

1074000:AFK65 RS17250
gene id: 1074000:AFK65_RS17250
uniprot id: A0A376EYE8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).

1074000:AFK65 RS12615
gene id: 1074000:AFK65_RS12615
uniprot id: A0A376EMB0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS14085
gene id: 1074000:AFK65_RS14085
uniprot id: A0A376EQB3
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS13850
gene id: 1074000:AFK65_RS13850
uniprot id: A0A376ERG2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

1074000:AFK65 RS10395
gene id: 1074000:AFK65_RS10395
uniprot id: A0A376EFY4
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1074000:AFK65 RS08905
gene id: 1074000:AFK65_RS08905
uniprot id: A0A376ECS4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS05425
gene id: 1074000:AFK65_RS05425
uniprot id: A0A376E5H4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxH family.
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.
messages: Binds 2 Mn(2+) ions per subunit in a binuclear metal center.
messages: Cell inner membrane
messages: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1074000:AFK65 RS03025
gene id: 1074000:AFK65_RS03025
uniprot id: A0A376E0U2
names: Function
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown.

1074000:AFK65 RS15665
gene id: 1074000:AFK65_RS15665
uniprot id: A0A376ET30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

1074000:AFK65 RS01060
gene id: 1074000:AFK65_RS01060
uniprot id: A0A376DXE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

1074000:AFK65 RS03260
gene id: 1074000:AFK65_RS03260
uniprot id: A0A376E156
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS08065
gene id: 1074000:AFK65_RS08065
uniprot id: A0A376EBM6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS04240
gene id: 1074000:AFK65_RS04240
uniprot id: A0A376E3D0
names: Function
names: Similarity
messages: Belongs to the FrsA family.
messages: Catalyzes the hydrolysis of esters.

1074000:AFK65 RS03185
gene id: 1074000:AFK65_RS03185
uniprot id: A0A376E1Q6
names: Caution
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. GpmB subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS16450
gene id: 1074000:AFK65_RS16450
uniprot id: A0A376EYH3
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1074000:AFK65 RS19685
gene id: 1074000:AFK65_RS19685
uniprot id: A0A376F048
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS00065
gene id: 1074000:AFK65_RS00065
uniprot id: A0A376DX33
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1074000:AFK65 RS07835
gene id: 1074000:AFK65_RS07835
uniprot id: A0A376EC22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1074000:AFK65 RS17170
gene id: 1074000:AFK65_RS17170
uniprot id: A0A376EY91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1074000:AFK65 RS02605
gene id: 1074000:AFK65_RS02605
uniprot id: A0A376E1B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

1074000:AFK65 RS14425
gene id: 1074000:AFK65_RS14425
uniprot id: A0A376EQ78
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1074000:AFK65 RS00970
gene id: 1074000:AFK65_RS00970
uniprot id: A0A376DYR9
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS18155
gene id: 1074000:AFK65_RS18155
uniprot id: A0A376EZY5
names: Function
names: Similarity
messages: Belongs to the precorrin methyltransferase family.
messages: In the C-terminal section; belongs to the precorrin methyltransferase family.
messages: In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
messages: Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.

1074000:AFK65 RS01580
gene id: 1074000:AFK65_RS01580
uniprot id: A0A376DYG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1074000:AFK65 RS18390
gene id: 1074000:AFK65_RS18390
uniprot id: A0A376F078
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

1074000:AFK65 RS07005
gene id: 1074000:AFK65_RS07005
uniprot id: A0A376E7M7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

1074000:AFK65 RS05405
gene id: 1074000:AFK65_RS05405
uniprot id: A0A376E5G5
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1074000:AFK65 RS15190
gene id: 1074000:AFK65_RS15190
uniprot id: A0A376ERY6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1074000:AFK65 RS00250
gene id: 1074000:AFK65_RS00250
uniprot id: A0A376DWT9
names: Similarity
messages: Belongs to the ClpA/ClpB family.

1074000:AFK65 RS18295
gene id: 1074000:AFK65_RS18295
uniprot id: A0A376EZU4
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family. GreB subfamily.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.

1074000:AFK65 RS10660
gene id: 1074000:AFK65_RS10660
uniprot id: A0A376EIC0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

1074000:AFK65 RS17960
gene id: 1074000:AFK65_RS17960
uniprot id: A0A376F0X6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1074000:AFK65 RS13230
gene id: 1074000:AFK65_RS13230
uniprot id: A0A376EPV7
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.
messages: Toroid-shaped homodecamer, composed of two pentamers of five dimers.

1074000:AFK65 RS17620
gene id: 1074000:AFK65_RS17620
uniprot id: A0A376EX68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute-binding protein (MalE).

1074000:AFK65 RS13855
gene id: 1074000:AFK65_RS13855
uniprot id: A0A376EQ86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the DAO family.
messages: In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family.

1074000:AFK65 RS13950
gene id: 1074000:AFK65_RS13950
uniprot id: A0A376ERQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

1074000:AFK65 RS11020
gene id: 1074000:AFK65_RS11020
uniprot id: A0A376EJ70
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

1074000:AFK65 RS12755
gene id: 1074000:AFK65_RS12755
uniprot id: A0A376EM25
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: In the N-terminal section; belongs to the histidinol-phosphatase family.

1074000:AFK65 RS19615
gene id: 1074000:AFK65_RS19615
uniprot id: A0A376F025
names: Function
names: Similarity
names: Subunit
messages: A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis.
messages: Belongs to the YihI family.
messages: Interacts with Der.

1074000:AFK65 RS10795
gene id: 1074000:AFK65_RS10795
uniprot id: A0A376EJJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

1074000:AFK65 RS03905
gene id: 1074000:AFK65_RS03905
uniprot id: A0A376E3G1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dGTPase family. Type 1 subfamily.
messages: Homotetramer.
messages: dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs.

1074000:AFK65 RS18690
gene id: 1074000:AFK65_RS18690
uniprot id: A0A376F0K6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmJ family.
messages: Cytoplasm
messages: Specifically methylates the guanosine in position 1516 of 16S rRNA.

1074000:AFK65 RS00855
gene id: 1074000:AFK65_RS00855
uniprot id: A0A376DX29
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1074000:AFK65 RS12435
gene id: 1074000:AFK65_RS12435
uniprot id: A0A376ELF0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

1074000:AFK65 RS18965
gene id: 1074000:AFK65_RS18965
uniprot id: A0A376F256
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1074000:AFK65 RS01350
gene id: 1074000:AFK65_RS01350
uniprot id: A0A376DXY0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholipase A1 family.
messages: Binds 1 Ca(2+) ion per monomer. In the dimeric form the Ca(2+) is bound by different amino acids with binding of each Ca(2+) shared with ligands coming from each monomer. The Ca(2+) ion may have a role in catalysis.
messages: Cell outer membrane
messages: Homodimer; dimerization is reversible, and the dimeric form is the active one.
messages: Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities.
messages: Membrane

1074000:AFK65 RS11115
gene id: 1074000:AFK65_RS11115
uniprot id: A0A376EHE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YciB family.
messages: Cell inner membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.

1074000:AFK65 RS03960
gene id: 1074000:AFK65_RS03960
uniprot id: A0A376E486
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
messages: Homodimer.

1074000:AFK65 RS03790
gene id: 1074000:AFK65_RS03790
uniprot id: A0A376E1L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS12860
gene id: 1074000:AFK65_RS12860
uniprot id: A0A376EMC8
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

1074000:AFK65 RS02265
gene id: 1074000:AFK65_RS02265
uniprot id: A0A376DZ95
names: Similarity
messages: Belongs to the peptidase C56 family.

1074000:AFK65 RS03695
gene id: 1074000:AFK65_RS03695
uniprot id: A0A376E316
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
messages: Membrane

1074000:AFK65 RS08725
gene id: 1074000:AFK65_RS08725
uniprot id: A0A376ED00
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1074000:AFK65 RS05990
gene id: 1074000:AFK65_RS05990
uniprot id: A0A376E591
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1074000:AFK65 RS01845
gene id: 1074000:AFK65_RS01845
uniprot id: A0A376E053
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

1074000:AFK65 RS05925
gene id: 1074000:AFK65_RS05925
uniprot id: A0A376E5K1
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

1074000:AFK65 RS03810
gene id: 1074000:AFK65_RS03810
uniprot id: A0A376E1M9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1074000:AFK65 RS07250
gene id: 1074000:AFK65_RS07250
uniprot id: A0A376EAS8
names: Similarity
messages: Belongs to the acylphosphatase family.

1074000:AFK65 RS13430
gene id: 1074000:AFK65_RS13430
uniprot id: A0A376EPQ6
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

1074000:AFK65 RS04535
gene id: 1074000:AFK65_RS04535
uniprot id: A0A376E2Z3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS02895
gene id: 1074000:AFK65_RS02895
uniprot id: A0A376E0E0
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS07900
gene id: 1074000:AFK65_RS07900
uniprot id: A0A376EBA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

1074000:AFK65 RS19380
gene id: 1074000:AFK65_RS19380
uniprot id: A0A376EYT5
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.

1074000:AFK65 RS16640
gene id: 1074000:AFK65_RS16640
uniprot id: A0A376EYU1
names: Similarity
messages: Belongs to the VgrG protein family.

1074000:AFK65 RS11665
gene id: 1074000:AFK65_RS11665
uniprot id: A0A376EIG0
names: Similarity
messages: Belongs to the KAE1 / TsaD family. TsaB subfamily.

1074000:AFK65 RS10970
gene id: 1074000:AFK65_RS10970
uniprot id: A0A376EIW7
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

1074000:AFK65 RS14245
gene id: 1074000:AFK65_RS14245
uniprot id: A0A376EPS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methylthioribose kinase family.
messages: Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.
messages: Homodimer.

1074000:AFK65 RS01655
gene id: 1074000:AFK65_RS01655
uniprot id: A0A376DYA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rsd/AlgQ family.
messages: Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
messages: Cytoplasm
messages: Interacts with RpoD.

1074000:AFK65 RS17545
gene id: 1074000:AFK65_RS17545
uniprot id: A0A376EX28
names: Function
names: Similarity
messages: Belongs to the Dus family. DusA subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.

1074000:AFK65 RS00510
gene id: 1074000:AFK65_RS00510
uniprot id: A0A376DYK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

1074000:AFK65 RS14600
gene id: 1074000:AFK65_RS14600
uniprot id: A0A376EQL4
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS21245
gene id: 1074000:AFK65_RS21245
uniprot id: A0A376EVW7
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS05075
gene id: 1074000:AFK65_RS05075
uniprot id: A0A376E3R4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

1074000:AFK65 RS09280
gene id: 1074000:AFK65_RS09280
uniprot id: A0A376EEI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS07415
gene id: 1074000:AFK65_RS07415
uniprot id: A0A376E9V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

1074000:AFK65 RS02005
gene id: 1074000:AFK65_RS02005
uniprot id: A0A376DZN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RapZ-like family. RapZ subfamily.
messages: Homotrimer.
messages: Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS.

1074000:AFK65 RS05235
gene id: 1074000:AFK65_RS05235
uniprot id: A0A376E400
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1074000:AFK65 RS04780
gene id: 1074000:AFK65_RS04780
uniprot id: A0A376E3P2
names: Similarity
messages: Belongs to the UPF0178 family.

1074000:AFK65 RS07760
gene id: 1074000:AFK65_RS07760
uniprot id: A0A376E9J0
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

1074000:AFK65 RS13250
gene id: 1074000:AFK65_RS13250
uniprot id: A0A376EQF7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS19530
gene id: 1074000:AFK65_RS19530
uniprot id: A0A376F1J0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS14945
gene id: 1074000:AFK65_RS14945
uniprot id: A0A376ES04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1074000:AFK65 RS07460
gene id: 1074000:AFK65_RS07460
uniprot id: A0A376E9F5
names: Function
messages: May be involved in the biogenesis of curli organelles.

1074000:AFK65 RS03995
gene id: 1074000:AFK65_RS03995
uniprot id: A0A376E206
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1074000:AFK65 RS15825
gene id: 1074000:AFK65_RS15825
uniprot id: A0A376ETJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Membrane

1074000:AFK65 RS18960
gene id: 1074000:AFK65_RS18960
uniprot id: A0A376EZ55
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1074000:AFK65 RS04820
gene id: 1074000:AFK65_RS04820
uniprot id: A0A376E4Z2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. SbcC subfamily.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

1074000:AFK65 RS18205
gene id: 1074000:AFK65_RS18205
uniprot id: A0A376F006
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DamX family.
messages: Cell inner membrane
messages: Non-essential cell division protein.
messages: The SPOR domain binds septal peptidoglycans and is required to target DamX to the septal ring.

1074000:AFK65 RS21345
gene id: 1074000:AFK65_RS21345
uniprot id: A0A376EZF4
names: Similarity
messages: Belongs to the EcnA/EcnB lipoprotein family.

1074000:AFK65 RS16800
gene id: 1074000:AFK65_RS16800
uniprot id: A0A376EWG0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS14375
gene id: 1074000:AFK65_RS14375
uniprot id: A0A376ESS4
names: Subunit
messages: Homodimer.

1074000:AFK65 RS12940
gene id: 1074000:AFK65_RS12940
uniprot id: A0A376ENN6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS06380
gene id: 1074000:AFK65_RS06380
uniprot id: A0A376E683
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS14460
gene id: 1074000:AFK65_RS14460
uniprot id: A0A376ERQ6
names: Similarity
messages: Belongs to the ArsC family.

1074000:AFK65 RS03415
gene id: 1074000:AFK65_RS03415
uniprot id: A0A376E1A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1074000:AFK65 RS01900
gene id: 1074000:AFK65_RS01900
uniprot id: A0A376DZJ0
names: Similarity
messages: Belongs to the barstar family.

1074000:AFK65 RS10405
gene id: 1074000:AFK65_RS10405
uniprot id: A0A376EGF9
names: Function
messages: Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.

1074000:AFK65 RS01840
gene id: 1074000:AFK65_RS01840
uniprot id: A0A376DYN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1074000:AFK65 RS20125
gene id: 1074000:AFK65_RS20125
uniprot id: A0A376KRK1
names: Similarity
messages: Belongs to the IucA/IucC family.

1074000:AFK65 RS10590
gene id: 1074000:AFK65_RS10590
uniprot id: A0A376EGC6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS20115
gene id: 1074000:AFK65_RS20115
uniprot id: A0A376KQZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1074000:AFK65 RS03515
gene id: 1074000:AFK65_RS03515
uniprot id: A0A376E1A6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS07065
gene id: 1074000:AFK65_RS07065
uniprot id: A0A376E7R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MukF family.
messages: Interacts, and probably forms a ternary complex, with MukE and MukB via its C-terminal region. The complex formation is stimulated by calcium or magnesium. It is required for an interaction between MukE and MukB.
messages: Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity.
messages: nucleoid

1074000:AFK65 RS10200
gene id: 1074000:AFK65_RS10200
uniprot id: A0A376EGC3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS02830
gene id: 1074000:AFK65_RS02830
uniprot id: A0A376E1Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins.
messages: Periplasm

1074000:AFK65 RS04740
gene id: 1074000:AFK65_RS04740
uniprot id: A0A376E3L9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1074000:AFK65 RS17140
gene id: 1074000:AFK65_RS17140
uniprot id: A0A376EY63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm
messages: Monomer.

1074000:AFK65 RS17940
gene id: 1074000:AFK65_RS17940
uniprot id: A0A376EY55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1074000:AFK65 RS04690
gene id: 1074000:AFK65_RS04690
uniprot id: A0A376E3J0
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1074000:AFK65 RS02300
gene id: 1074000:AFK65_RS02300
uniprot id: A0A376DZC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1074000:AFK65 RS03110
gene id: 1074000:AFK65_RS03110
uniprot id: A0A376E0M5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

1074000:AFK65 RS03165
gene id: 1074000:AFK65_RS03165
uniprot id: A0A376E1P5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1074000:AFK65 RS05795
gene id: 1074000:AFK65_RS05795
uniprot id: A0A376E4T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1074000:AFK65 RS06985
gene id: 1074000:AFK65_RS06985
uniprot id: A0A376E7L8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

1074000:AFK65 RS12875
gene id: 1074000:AFK65_RS12875
uniprot id: A0A376EP13
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

1074000:AFK65 RS03350
gene id: 1074000:AFK65_RS03350
uniprot id: A0A376E2H1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS02105
gene id: 1074000:AFK65_RS02105
uniprot id: A0A376DYW8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1074000:AFK65 RS16065
gene id: 1074000:AFK65_RS16065
uniprot id: A0A376EUV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1074000:AFK65 RS16105
gene id: 1074000:AFK65_RS16105
uniprot id: A0A376EXK4
names: Similarity
messages: Belongs to the YggT family.

1074000:AFK65 RS04475
gene id: 1074000:AFK65_RS04475
uniprot id: A0A376E2V1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Gfo/Idh/MocA family.
messages: Homotetramer.
messages: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).

1074000:AFK65 RS21405
gene id: 1074000:AFK65_RS21405
uniprot id: A0A376F0N1
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

1074000:AFK65 RS08415
gene id: 1074000:AFK65_RS08415
uniprot id: A0A376EAT3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1074000:AFK65 RS13665
gene id: 1074000:AFK65_RS13665
uniprot id: A0A376ENE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1074000:AFK65 RS20475
gene id: 1074000:AFK65_RS20475
uniprot id: A0A376KPM5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1074000:AFK65 RS10085
gene id: 1074000:AFK65_RS10085
uniprot id: A0A376EH21
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1074000:AFK65 RS14705
gene id: 1074000:AFK65_RS14705
uniprot id: A0A376ETM0
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS14585
gene id: 1074000:AFK65_RS14585
uniprot id: A0A376ERC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1074000:AFK65 RS14645
gene id: 1074000:AFK65_RS14645
uniprot id: A0A376EQQ9
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

1074000:AFK65 RS15730
gene id: 1074000:AFK65_RS15730
uniprot id: A0A376ET94
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

1074000:AFK65 RS20055
gene id: 1074000:AFK65_RS20055
uniprot id: A0A376KPP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A26 family.
messages: Cell outer membrane
messages: Membrane

1074000:AFK65 RS05785
gene id: 1074000:AFK65_RS05785
uniprot id: A0A376E619
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. MrdA subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall.
messages: Cell inner membrane

1074000:AFK65 RS07315
gene id: 1074000:AFK65_RS07315
uniprot id: A0A376E8N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1074000:AFK65 RS11595
gene id: 1074000:AFK65_RS11595
uniprot id: A0A376EI81
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: Multifunctional regulator of fatty acid metabolism.

1074000:AFK65 RS18130
gene id: 1074000:AFK65_RS18130
uniprot id: A0A376EZX1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1074000:AFK65 RS17930
gene id: 1074000:AFK65_RS17930
uniprot id: A0A376EXA4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1074000:AFK65 RS04890
gene id: 1074000:AFK65_RS04890
uniprot id: A0A376E3E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1074000:AFK65 RS16310
gene id: 1074000:AFK65_RS16310
uniprot id: A0A376EX83
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1074000:AFK65 RS13650
gene id: 1074000:AFK65_RS13650
uniprot id: A0A376ENE1
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

1074000:AFK65 RS18485
gene id: 1074000:AFK65_RS18485
uniprot id: A0A376F0B6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

1074000:AFK65 RS17295
gene id: 1074000:AFK65_RS17295
uniprot id: A0A376EYG9
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

1074000:AFK65 RS15545
gene id: 1074000:AFK65_RS15545
uniprot id: A0A376EV61
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS18995
gene id: 1074000:AFK65_RS18995
uniprot id: A0A376EZD6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

1074000:AFK65 RS01485
gene id: 1074000:AFK65_RS01485
uniprot id: A0A376DY50
names: Similarity
messages: Belongs to the IMPACT family.

1074000:AFK65 RS02355
gene id: 1074000:AFK65_RS02355
uniprot id: A0A376E0D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 32 family.
messages: Cytoplasm
messages: Enables the bacterium to metabolize sucrose as a sole carbon source.

1074000:AFK65 RS04075
gene id: 1074000:AFK65_RS04075
uniprot id: A0A376E2H4
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1074000:AFK65 RS19550
gene id: 1074000:AFK65_RS19550
uniprot id: A0A376F199
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Phosphorylates 6-deoxy-6-sulfo-D-fructose (SF) to 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP).

1074000:AFK65 RS02450
gene id: 1074000:AFK65_RS02450
uniprot id: A0A376E0I7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Has been proposed to be a redox modulator.
messages: Membrane

1074000:AFK65 RS05340
gene id: 1074000:AFK65_RS05340
uniprot id: A0A376E5V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1074000:AFK65 RS16255
gene id: 1074000:AFK65_RS16255
uniprot id: A0A376EVA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiK family.
messages: Cytoplasm
messages: Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.

1074000:AFK65 RS05955
gene id: 1074000:AFK65_RS05955
uniprot id: A0A376E5I4
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

1074000:AFK65 RS00695
gene id: 1074000:AFK65_RS00695
uniprot id: A0A376DY81
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1074000:AFK65 RS13060
gene id: 1074000:AFK65_RS13060
uniprot id: A0A376EM53
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1074000:AFK65 RS15490
gene id: 1074000:AFK65_RS15490
uniprot id: A0A376EVN8
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS00940
gene id: 1074000:AFK65_RS00940
uniprot id: A0A376DXJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WecD family.
messages: Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA).
messages: Homodimer.

1074000:AFK65 RS15635
gene id: 1074000:AFK65_RS15635
uniprot id: A0A376ESZ4
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
messages: Belongs to the RecC family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

1074000:AFK65 RS02505
gene id: 1074000:AFK65_RS02505
uniprot id: A0A376E0M1
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1074000:AFK65 RS01795
gene id: 1074000:AFK65_RS01795
uniprot id: A0A376DYG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1074000:AFK65 RS19775
gene id: 1074000:AFK65_RS19775
uniprot id: A0A376EZ75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1074000:AFK65 RS17740
gene id: 1074000:AFK65_RS17740
uniprot id: A0A376EX45
names: Cofactor
messages: Can also use Mn(2+) ion.

1074000:AFK65 RS05825
gene id: 1074000:AFK65_RS05825
uniprot id: A0A376E5K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS14515
gene id: 1074000:AFK65_RS14515
uniprot id: A0A376ER93
names: Similarity
messages: Belongs to the peptidase S33 family.

1074000:AFK65 RS11965
gene id: 1074000:AFK65_RS11965
uniprot id: A0A376ELY8
names: Cofactor
messages: Binds 1 Mg(2+) ion per subunit.

1074000:AFK65 RS03370
gene id: 1074000:AFK65_RS03370
uniprot id: A0A376E143
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1074000:AFK65 RS10435
gene id: 1074000:AFK65_RS10435
uniprot id: A0A376EIQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS13610
gene id: 1074000:AFK65_RS13610
uniprot id: A0A376EQR2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: Membrane

1074000:AFK65 RS01430
gene id: 1074000:AFK65_RS01430
uniprot id: A0A376DYY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1074000:AFK65 RS07740
gene id: 1074000:AFK65_RS07740
uniprot id: A0A376EA53
names: Similarity
names: Subunit
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

1074000:AFK65 RS01670
gene id: 1074000:AFK65_RS01670
uniprot id: A0A376DZX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

1074000:AFK65 RS05770
gene id: 1074000:AFK65_RS05770
uniprot id: A0A376E609
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

1074000:AFK65 RS14275
gene id: 1074000:AFK65_RS14275
uniprot id: A0A376ESA3
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS14990
gene id: 1074000:AFK65_RS14990
uniprot id: A0A376EUC0
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

1074000:AFK65 RS04870
gene id: 1074000:AFK65_RS04870
uniprot id: A0A376E3D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1074000:AFK65 RS07020
gene id: 1074000:AFK65_RS07020
uniprot id: A0A376E7K0
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

1074000:AFK65 RS11895
gene id: 1074000:AFK65_RS11895
uniprot id: A0A376ELH7
names: Similarity
names: Subunit
messages: Belongs to the KHG/KDPG aldolase family.
messages: Homotrimer.

1074000:AFK65 RS15725
gene id: 1074000:AFK65_RS15725
uniprot id: A0A376ETX4
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1074000:AFK65 RS19815
gene id: 1074000:AFK65_RS19815
uniprot id: A0A376F1K5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS01925
gene id: 1074000:AFK65_RS01925
uniprot id: A0A376DYL7
names: Similarity
messages: Belongs to the peptidase S1C family.

1074000:AFK65 RS02510
gene id: 1074000:AFK65_RS02510
uniprot id: A0A376DZN6
names: Similarity
names: Subunit
messages: Belongs to the RutC family.
messages: Homotrimer.

1074000:AFK65 RS12300
gene id: 1074000:AFK65_RS12300
uniprot id: A0A376EKL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS10805
gene id: 1074000:AFK65_RS10805
uniprot id: A0A376EHL9
names: Cofactor
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.

1074000:AFK65 RS07500
gene id: 1074000:AFK65_RS07500
uniprot id: A0A376EBA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyltransferase 3 family. OpgC subfamily.
messages: Cell membrane
messages: Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane.

1074000:AFK65 RS18245
gene id: 1074000:AFK65_RS18245
uniprot id: A0A376EZS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

1074000:AFK65 RS16075
gene id: 1074000:AFK65_RS16075
uniprot id: A0A376EUW0
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

1074000:AFK65 RS05775
gene id: 1074000:AFK65_RS05775
uniprot id: A0A376E5G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RlpA family.
messages: Cell membrane
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

1074000:AFK65 RS03070
gene id: 1074000:AFK65_RS03070
uniprot id: A0A376E0S7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.
messages: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

1074000:AFK65 RS18630
gene id: 1074000:AFK65_RS18630
uniprot id: A0A376EYU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcrB family.
messages: Cell membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis. Essential for lipoprotein maturation under conditions where membrane fluidity may be altered.

1074000:AFK65 RS01340
gene id: 1074000:AFK65_RS01340
uniprot id: A0A376DY00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

1074000:AFK65 RS19590
gene id: 1074000:AFK65_RS19590
uniprot id: A0A376F2U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1074000:AFK65 RS07390
gene id: 1074000:AFK65_RS07390
uniprot id: A0A376E9B1
names: Similarity
messages: Belongs to the PhoH family.

1074000:AFK65 RS18975
gene id: 1074000:AFK65_RS18975
uniprot id: A0A376F0M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyltransferase 3 family.
messages: Cell inner membrane
messages: Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units.

1074000:AFK65 RS14840
gene id: 1074000:AFK65_RS14840
uniprot id: A0A376ER42
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1074000:AFK65 RS03855
gene id: 1074000:AFK65_RS03855
uniprot id: A0A376E3G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1074000:AFK65 RS15465
gene id: 1074000:AFK65_RS15465
uniprot id: A0A376EUH1
names: Function
names: Similarity
messages: Belongs to the NanE family.
messages: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).

1074000:AFK65 RS14385
gene id: 1074000:AFK65_RS14385
uniprot id: A0A376EQ38
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1074000:AFK65 RS07765
gene id: 1074000:AFK65_RS07765
uniprot id: A0A376E912
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS17260
gene id: 1074000:AFK65_RS17260
uniprot id: A0A376EWI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FrdC family.
messages: Cell membrane
messages: Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).
messages: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth. Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.

1074000:AFK65 RS16220
gene id: 1074000:AFK65_RS16220
uniprot id: A0A376EWD2
names: Function
names: Similarity
names: Subunit
messages: Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process.
messages: Belongs to the Nudix hydrolase family. NudF subfamily.
messages: Homodimer.

1074000:AFK65 RS05325
gene id: 1074000:AFK65_RS05325
uniprot id: A0A376E464
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

1074000:AFK65 RS14660
gene id: 1074000:AFK65_RS14660
uniprot id: A0A376ES70
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 2 iron ions per dimer. The dimer may bind additional iron ions.
messages: Homodimer; may form tetramers and higher multimers.
messages: Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.

1074000:AFK65 RS11565
gene id: 1074000:AFK65_RS11565
uniprot id: A0A376EJ49
names: Similarity
messages: Belongs to the flavodoxin family.

1074000:AFK65 RS04995
gene id: 1074000:AFK65_RS04995
uniprot id: A0A376E599
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane
messages: The cytochrome bo(3) ubiquinol oxidase complex is a heterooctamer of two A chains, two B chains, two C chains and two D chains.

1074000:AFK65 RS05440
gene id: 1074000:AFK65_RS05440
uniprot id: A0A376E5X5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS07680
gene id: 1074000:AFK65_RS07680
uniprot id: A0A376E8T8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase E/G family. RNase E subfamily.
messages: Belongs to the RNase E/G family. RNase G subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per homotetramer.
messages: Cell inner membrane
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, RNase E assembles into a homotetramer formed by a dimer of dimers.
messages: Cytoplasm
messages: Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.

1074000:AFK65 RS09265
gene id: 1074000:AFK65_RS09265
uniprot id: A0A376ECU0
names: Similarity
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.

1074000:AFK65 RS06150
gene id: 1074000:AFK65_RS06150
uniprot id: A0A376E7A5
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

1074000:AFK65 RS15870
gene id: 1074000:AFK65_RS15870
uniprot id: A0A376EVA2
names: Similarity
messages: Belongs to the RecJ family.

1074000:AFK65 RS06880
gene id: 1074000:AFK65_RS06880
uniprot id: A0A376E8J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1074000:AFK65 RS11360
gene id: 1074000:AFK65_RS11360
uniprot id: A0A376EHW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1074000:AFK65 RS01390
gene id: 1074000:AFK65_RS01390
uniprot id: A0A376DZI2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

1074000:AFK65 RS01820
gene id: 1074000:AFK65_RS01820
uniprot id: A0A376DYM0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrQ family.
messages: Binds 1 FMN per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Membrane
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.

1074000:AFK65 RS15695
gene id: 1074000:AFK65_RS15695
uniprot id: A0A376EWD0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.
messages: Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS13345
gene id: 1074000:AFK65_RS13345
uniprot id: A0A376EQ36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS19575
gene id: 1074000:AFK65_RS19575
uniprot id: A0A376F1A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
messages: Membrane

1074000:AFK65 RS05745
gene id: 1074000:AFK65_RS05745
uniprot id: A0A376E553
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TatA/E family. TatE subfamily.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA.

1074000:AFK65 RS16300
gene id: 1074000:AFK65_RS16300
uniprot id: A0A376EUQ6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1074000:AFK65 RS06525
gene id: 1074000:AFK65_RS06525
uniprot id: A0A376E844
names: Function
names: Similarity
messages: Belongs to the DtxR/MntR family.
messages: In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP.

1074000:AFK65 RS14440
gene id: 1074000:AFK65_RS14440
uniprot id: A0A376ET03
names: Subcellular Location Annotation
messages: Cytoplasm

1074000:AFK65 RS11385
gene id: 1074000:AFK65_RS11385
uniprot id: A0A376EJM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

1074000:AFK65 RS06930
gene id: 1074000:AFK65_RS06930
uniprot id: A0A376E8U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Membrane

1074000:AFK65 RS15555
gene id: 1074000:AFK65_RS15555
uniprot id: A0A376EUQ3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Xni family.
messages: Binds 1 K(+) per subunit. The potassium ion strongly increases the affinity for DNA.
messages: Binds 2 Mg(2+) per subunit. Only one magnesium ion has a direct interaction with the protein, the other interactions are indirect.
messages: Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.

1074000:AFK65 RS01665
gene id: 1074000:AFK65_RS01665
uniprot id: A0A376DYB3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS18450
gene id: 1074000:AFK65_RS18450
uniprot id: A0A376F0E7
names: Similarity
messages: Belongs to the pirin family.

1074000:AFK65 RS03120
gene id: 1074000:AFK65_RS03120
uniprot id: A0A376E0Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS12560
gene id: 1074000:AFK65_RS12560
uniprot id: A0A376EL04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Gram-negative porin family.
messages: Cell outer membrane
messages: Membrane

1074000:AFK65 RS06215
gene id: 1074000:AFK65_RS06215
uniprot id: A0A376E681
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane
messages: Required for nicotinamide riboside transport across the inner membrane.

1074000:AFK65 RS04930
gene id: 1074000:AFK65_RS04930
uniprot id: A0A376E4P1
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

1074000:AFK65 RS08305
gene id: 1074000:AFK65_RS08305
uniprot id: A0A376EC21
names: Function
names: Similarity
messages: Belongs to the catalase family. HPII subfamily.
messages: Serves to protect cells from the toxic effects of hydrogen peroxide.

1074000:AFK65 RS08425
gene id: 1074000:AFK65_RS08425
uniprot id: A0A376EBP0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1074000:AFK65 RS02290
gene id: 1074000:AFK65_RS02290
uniprot id: A0A376DZJ6
names: Similarity
messages: Belongs to the UPF0102 family.

1074000:AFK65 RS19640
gene id: 1074000:AFK65_RS19640
uniprot id: A0A376F033
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.
messages: Belongs to the SrkA/RdoA protein kinase family.
messages: Cytoplasm
messages: Monomer.

1074000:AFK65 RS18990
gene id: 1074000:AFK65_RS18990
uniprot id: A0A376F262
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

1074000:AFK65 RS06885
gene id: 1074000:AFK65_RS06885
uniprot id: A0A376E7U4
names: Subcellular Location Annotation
messages: Cytoplasm

1074000:AFK65 RS10700
gene id: 1074000:AFK65_RS10700
uniprot id: A0A376EH00
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.
messages: Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin.

1074000:AFK65 RS08795
gene id: 1074000:AFK65_RS08795
uniprot id: A0A376ED57
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Binds 2 potassium ions per subunit.
messages: Dimer of dimers.
messages: Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS02340
gene id: 1074000:AFK65_RS02340
uniprot id: A0A376DZG3
names: Similarity
messages: Belongs to the pirin family.

1074000:AFK65 RS04410
gene id: 1074000:AFK65_RS04410
uniprot id: A0A376E2R4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1074000:AFK65 RS19985
gene id: 1074000:AFK65_RS19985
uniprot id: A0A376KRF2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS05175
gene id: 1074000:AFK65_RS05175
uniprot id: A0A376E6C6
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS03465
gene id: 1074000:AFK65_RS03465
uniprot id: A0A376E141
names: Similarity
messages: Belongs to the ribulokinase family.

1074000:AFK65 RS18525
gene id: 1074000:AFK65_RS18525
uniprot id: A0A376F0H0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS15975
gene id: 1074000:AFK65_RS15975
uniprot id: A0A376EWA1
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1074000:AFK65 RS07870
gene id: 1074000:AFK65_RS07870
uniprot id: A0A376EAS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS05920
gene id: 1074000:AFK65_RS05920
uniprot id: A0A376E6R6
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1074000:AFK65 RS12150
gene id: 1074000:AFK65_RS12150
uniprot id: A0A376EME2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FlhD family.
messages: Cytoplasm
messages: Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
messages: Homodimer; disulfide-linked. Forms a heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.
messages: The C-terminal region contains a putative helix-turn-helix (HTH) motif, suggesting that this region may bind DNA.

1074000:AFK65 RS11705
gene id: 1074000:AFK65_RS11705
uniprot id: A0A376EJ59
names: Similarity
messages: Belongs to the UPF0181 family.

1074000:AFK65 RS17090
gene id: 1074000:AFK65_RS17090
uniprot id: A0A376EWX3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

1074000:AFK65 RS15055
gene id: 1074000:AFK65_RS15055
uniprot id: A0A376ETI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamE family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

1074000:AFK65 RS00565
gene id: 1074000:AFK65_RS00565
uniprot id: A0A376DWH2
names: Caution
names: Function
names: Similarity
messages: Belongs to the rhamnulokinase family.
messages: Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS08845
gene id: 1074000:AFK65_RS08845
uniprot id: A0A376ECN8
names: Similarity
messages: Belongs to the VgrG protein family.

1074000:AFK65 RS06520
gene id: 1074000:AFK65_RS06520
uniprot id: A0A376E6I9
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS03065
gene id: 1074000:AFK65_RS03065
uniprot id: A0A376E0N7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1074000:AFK65 RS19770
gene id: 1074000:AFK65_RS19770
uniprot id: A0A376F1S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1074000:AFK65 RS17885
gene id: 1074000:AFK65_RS17885
uniprot id: A0A376EXF5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1074000:AFK65 RS14805
gene id: 1074000:AFK65_RS14805
uniprot id: A0A376EU16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1074000:AFK65 RS17415
gene id: 1074000:AFK65_RS17415
uniprot id: A0A376EWV5
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis.

1074000:AFK65 RS15655
gene id: 1074000:AFK65_RS15655
uniprot id: A0A376EUJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS08215
gene id: 1074000:AFK65_RS08215
uniprot id: A0A376EBT2
names: Similarity
messages: Belongs to the peptidase S49 family.

1074000:AFK65 RS15455
gene id: 1074000:AFK65_RS15455
uniprot id: A0A376EUX3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS18700
gene id: 1074000:AFK65_RS18700
uniprot id: A0A376F0A7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RlmJ family.
messages: Monomer.
messages: Specifically methylates the adenine in position 2030 of 23S rRNA.

1074000:AFK65 RS17965
gene id: 1074000:AFK65_RS17965
uniprot id: A0A376EY65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1074000:AFK65 RS17485
gene id: 1074000:AFK65_RS17485
uniprot id: A0A376EZ56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1074000:AFK65 RS01805
gene id: 1074000:AFK65_RS01805
uniprot id: A0A376E033
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1074000:AFK65 RS19280
gene id: 1074000:AFK65_RS19280
uniprot id: A0A376F2G7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
messages: Cytoplasm
messages: Homotetramer.

1074000:AFK65 RS08635
gene id: 1074000:AFK65_RS08635
uniprot id: A0A376EBF6
names: Similarity
messages: Belongs to the HypE family.

1074000:AFK65 RS19425
gene id: 1074000:AFK65_RS19425
uniprot id: A0A376F1F1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1074000:AFK65 RS20765
gene id: 1074000:AFK65_RS20765
uniprot id: A0A376E7J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.
messages: Belongs to the AcrZ family.
messages: Cell membrane
messages: Part of the AcrA-AcrB-AcrZ-TolC efflux pump, interacts directly with AcrB.

1074000:AFK65 RS17290
gene id: 1074000:AFK65_RS17290
uniprot id: A0A376F001
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.
messages: May be beta-lysylated on the epsilon-amino group of Lys-34 by the combined action of EpmA and EpmB, and then hydroxylated on the C5 position of the same residue by EpmC (if this protein is present). Lysylation is critical for the stimulatory effect of EF-P on peptide-bond formation. The lysylation moiety may extend toward the peptidyltransferase center and stabilize the terminal 3-CCA end of the tRNA. Hydroxylation of the C5 position on Lys-34 may allow additional potential stabilizing hydrogen-bond interactions with the P-tRNA.

1074000:AFK65 RS01320
gene id: 1074000:AFK65_RS01320
uniprot id: A0A376DZZ1
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1074000:AFK65 RS07845
gene id: 1074000:AFK65_RS07845
uniprot id: A0A376E9A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1074000:AFK65 RS14480
gene id: 1074000:AFK65_RS14480
uniprot id: A0A376ERS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1074000:AFK65 RS03930
gene id: 1074000:AFK65_RS03930
uniprot id: A0A376E2Y9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1074000:AFK65 RS04015
gene id: 1074000:AFK65_RS04015
uniprot id: A0A376E3N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1074000:AFK65 RS10155
gene id: 1074000:AFK65_RS10155
uniprot id: A0A376EGY0
names: Similarity
messages: Belongs to the mannitol dehydrogenase family. UxaB subfamily.

1074000:AFK65 RS13645
gene id: 1074000:AFK65_RS13645
uniprot id: A0A376EPN1
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

1074000:AFK65 RS05005
gene id: 1074000:AFK65_RS05005
uniprot id: A0A376E411
names: Similarity
messages: Belongs to the heat shock protein 70 family.

1074000:AFK65 RS08645
gene id: 1074000:AFK65_RS08645
uniprot id: A0A376EBD5
names: Similarity
messages: Belongs to the HupF/HypC family.

1074000:AFK65 RS04000
gene id: 1074000:AFK65_RS04000
uniprot id: A0A376E3L1
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1074000:AFK65 RS16785
gene id: 1074000:AFK65_RS16785
uniprot id: A0A376EVT8
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS17360
gene id: 1074000:AFK65_RS17360
uniprot id: A0A376EXE1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the KduI family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.

1074000:AFK65 RS15040
gene id: 1074000:AFK65_RS15040
uniprot id: A0A376ES78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1074000:AFK65 RS16115
gene id: 1074000:AFK65_RS16115
uniprot id: A0A376EUX4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1074000:AFK65 RS19560
gene id: 1074000:AFK65_RS19560
uniprot id: A0A376EZS3
names: Function
names: Similarity
messages: Belongs to the aldolase LacD family.
messages: Cleaves 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP) to form dihydroxyacetone phosphate (DHAP) and 3-sulfolactaldehyde (SLA).

1074000:AFK65 RS17810
gene id: 1074000:AFK65_RS17810
uniprot id: A0A376EX67
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1074000:AFK65 RS16575
gene id: 1074000:AFK65_RS16575
uniprot id: A0A376EVY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit subfamily.
messages: Cytoplasm
messages: Oligomer with a subunit composition of (alpha,beta,gamma)6.
messages: Represents a citryl-ACP lyase.

1074000:AFK65 RS14495
gene id: 1074000:AFK65_RS14495
uniprot id: A0A376ETG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GppA/Ppx family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS00735
gene id: 1074000:AFK65_RS00735
uniprot id: A0A376DWW9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M20A family. ArgE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of the amide bond of N(2)-acetylated L-amino acids. Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS03385
gene id: 1074000:AFK65_RS03385
uniprot id: A0A376E103
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily.
messages: Cell inner membrane
messages: Homodimer. Interacts with KefC.
messages: Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC.

1074000:AFK65 RS17585
gene id: 1074000:AFK65_RS17585
uniprot id: A0A376EZF1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Cell membrane
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

1074000:AFK65 RS06940
gene id: 1074000:AFK65_RS06940
uniprot id: A0A376EA73
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

1074000:AFK65 RS11445
gene id: 1074000:AFK65_RS11445
uniprot id: A0A376EI39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1074000:AFK65 RS21320
gene id: 1074000:AFK65_RS21320
uniprot id: A0A376EVU1
names: Similarity
messages: Belongs to the sterol desaturase family.

1074000:AFK65 RS16130
gene id: 1074000:AFK65_RS16130
uniprot id: A0A376EWR6
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

1074000:AFK65 RS07745
gene id: 1074000:AFK65_RS07745
uniprot id: A0A376E935
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

1074000:AFK65 RS09900
gene id: 1074000:AFK65_RS09900
uniprot id: A0A376EEJ2
names: Similarity
messages: Belongs to the manganese catalase family.

1074000:AFK65 RS14015
gene id: 1074000:AFK65_RS14015
uniprot id: A0A376ERA0
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

1074000:AFK65 RS13385
gene id: 1074000:AFK65_RS13385
uniprot id: A0A376EPP2
names: Similarity
messages: Belongs to the UPF0352 family.

1074000:AFK65 RS13485
gene id: 1074000:AFK65_RS13485
uniprot id: A0A376EQG1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Activation probably requires a transfer of a phosphate group from a His in the transmitter domain to an Asp in the receiver domain.
messages: Belongs to the RcsC family.
messages: Cell inner membrane
messages: Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane-associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB.
messages: Interacts with RcsD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1074000:AFK65 RS11805
gene id: 1074000:AFK65_RS11805
uniprot id: A0A376EL92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ProQ family.
messages: Cytoplasm
messages: RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism.

1074000:AFK65 RS05760
gene id: 1074000:AFK65_RS05760
uniprot id: A0A376E4S1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

1074000:AFK65 RS04160
gene id: 1074000:AFK65_RS04160
uniprot id: A0A376E2D3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Monomer.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

1074000:AFK65 RS17920
gene id: 1074000:AFK65_RS17920
uniprot id: A0A376EZD1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1074000:AFK65 RS04025
gene id: 1074000:AFK65_RS04025
uniprot id: A0A376E331
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

1074000:AFK65 RS08650
gene id: 1074000:AFK65_RS08650
uniprot id: A0A376EBF2
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

1074000:AFK65 RS15060
gene id: 1074000:AFK65_RS15060
uniprot id: A0A376ETW6
names: Similarity
messages: Belongs to the UPF0125 (RnfH) family.

1074000:AFK65 RS05230
gene id: 1074000:AFK65_RS05230
uniprot id: A0A376E5L4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1074000:AFK65 RS20185
gene id: 1074000:AFK65_RS20185
uniprot id: A0A376KTZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.
messages: Membrane

1074000:AFK65 RS02490
gene id: 1074000:AFK65_RS02490
uniprot id: A0A376DZP1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1074000:AFK65 RS18570
gene id: 1074000:AFK65_RS18570
uniprot id: A0A376F066
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

1074000:AFK65 RS08360
gene id: 1074000:AFK65_RS08360
uniprot id: A0A376EAL9
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1074000:AFK65 RS05535
gene id: 1074000:AFK65_RS05535
uniprot id: A0A376E4I5
names: Similarity
messages: Belongs to the glutathione peroxidase family.

1074000:AFK65 RS10455
gene id: 1074000:AFK65_RS10455
uniprot id: A0A376EGI6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS01650
gene id: 1074000:AFK65_RS01650
uniprot id: A0A376DZW7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

1074000:AFK65 RS08005
gene id: 1074000:AFK65_RS08005
uniprot id: A0A376E9Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS08625
gene id: 1074000:AFK65_RS08625
uniprot id: A0A376ECX9
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS16965
gene id: 1074000:AFK65_RS16965
uniprot id: A0A376EY70
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

1074000:AFK65 RS02315
gene id: 1074000:AFK65_RS02315
uniprot id: A0A376DZB9
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS17350
gene id: 1074000:AFK65_RS17350
uniprot id: A0A376EZ26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family. RcnA subfamily.
messages: Cell membrane
messages: Efflux system for nickel and cobalt.
messages: Membrane

1074000:AFK65 RS03690
gene id: 1074000:AFK65_RS03690
uniprot id: A0A376E1Q2
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1074000:AFK65 RS14145
gene id: 1074000:AFK65_RS14145
uniprot id: A0A376EPJ0
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS19195
gene id: 1074000:AFK65_RS19195
uniprot id: A0A376F0S2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.
messages: Cell inner membrane
messages: Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+). May be involved in zinc and iron detoxification by efflux.
messages: Homodimer.
messages: Membrane

1074000:AFK65 RS00270
gene id: 1074000:AFK65_RS00270
uniprot id: A0A376DW99
names: Similarity
messages: Belongs to the VgrG protein family.

1074000:AFK65 RS00915
gene id: 1074000:AFK65_RS00915
uniprot id: A0A376DY46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WzzB/Cld/Rol family.
messages: Cell inner membrane
messages: Membrane
messages: Modulates the polysaccharide chain length of enterobacterial common antigen (ECA).
messages: Probably part of a complex composed of WzxE, WzyE and WzzE.

1074000:AFK65 RS02900
gene id: 1074000:AFK65_RS02900
uniprot id: A0A376E0J8
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1074000:AFK65 RS01275
gene id: 1074000:AFK65_RS01275
uniprot id: A0A376DZ81
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

1074000:AFK65 RS21040
gene id: 1074000:AFK65_RS21040
uniprot id: A0A376EHH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GhoT/OrtT toxin family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS15370
gene id: 1074000:AFK65_RS15370
uniprot id: A0A376ESE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

1074000:AFK65 RS13195
gene id: 1074000:AFK65_RS13195
uniprot id: A0A376ENL3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion.
messages: Homodimer.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

1074000:AFK65 RS11735
gene id: 1074000:AFK65_RS11735
uniprot id: A0A376EK90
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport.

1074000:AFK65 RS17305
gene id: 1074000:AFK65_RS17305
uniprot id: A0A376EXA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1074000:AFK65 RS07750
gene id: 1074000:AFK65_RS07750
uniprot id: A0A376EAK5
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1074000:AFK65 RS13460
gene id: 1074000:AFK65_RS13460
uniprot id: A0A376EMX6
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1074000:AFK65 RS02560
gene id: 1074000:AFK65_RS02560
uniprot id: A0A376DZR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RraB family.
messages: Cytoplasm
messages: Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
messages: Interacts with the C-terminal region of Rne.

1074000:AFK65 RS04760
gene id: 1074000:AFK65_RS04760
uniprot id: A0A376E3P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS16465
gene id: 1074000:AFK65_RS16465
uniprot id: A0A376EV86
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1074000:AFK65 RS05110
gene id: 1074000:AFK65_RS05110
uniprot id: A0A376E4A0
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS08550
gene id: 1074000:AFK65_RS08550
uniprot id: A0A376EBS1
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1074000:AFK65 RS06980
gene id: 1074000:AFK65_RS06980
uniprot id: A0A376E9B6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS03360
gene id: 1074000:AFK65_RS03360
uniprot id: A0A376E2L2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1074000:AFK65 RS13775
gene id: 1074000:AFK65_RS13775
uniprot id: A0A376EQL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

1074000:AFK65 RS14455
gene id: 1074000:AFK65_RS14455
uniprot id: A0A376ESQ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48 family. BepA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state.
messages: Periplasm

1074000:AFK65 RS15345
gene id: 1074000:AFK65_RS15345
uniprot id: A0A376EVE1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS15535
gene id: 1074000:AFK65_RS15535
uniprot id: A0A376ETH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS05655
gene id: 1074000:AFK65_RS05655
uniprot id: A0A376E6Z4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.

1074000:AFK65 RS14665
gene id: 1074000:AFK65_RS14665
uniprot id: A0A376ERI2
names: Function
names: Similarity
messages: A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
messages: Belongs to the NifU family.

1074000:AFK65 RS07770
gene id: 1074000:AFK65_RS07770
uniprot id: A0A376E953
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1074000:AFK65 RS07430
gene id: 1074000:AFK65_RS07430
uniprot id: A0A376E8B9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.
messages: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
messages: Cytoplasm

1074000:AFK65 RS01810
gene id: 1074000:AFK65_RS01810
uniprot id: A0A376DZY1
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1074000:AFK65 RS08190
gene id: 1074000:AFK65_RS08190
uniprot id: A0A376EC73
names: Function
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.

1074000:AFK65 RS14530
gene id: 1074000:AFK65_RS14530
uniprot id: A0A376ESD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1074000:AFK65 RS15045
gene id: 1074000:AFK65_RS15045
uniprot id: A0A376ERH6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS18325
gene id: 1074000:AFK65_RS18325
uniprot id: A0A376EYF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
messages: Cytoplasm
messages: Monomer.
messages: The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.

1074000:AFK65 RS14730
gene id: 1074000:AFK65_RS14730
uniprot id: A0A376ERN6
names: Similarity
messages: Belongs to the P(II) protein family.

1074000:AFK65 RS15980
gene id: 1074000:AFK65_RS15980
uniprot id: A0A376EW24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

1074000:AFK65 RS14350
gene id: 1074000:AFK65_RS14350
uniprot id: A0A376EQ09
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

1074000:AFK65 RS19515
gene id: 1074000:AFK65_RS19515
uniprot id: A0A376F1H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1074000:AFK65 RS05685
gene id: 1074000:AFK65_RS05685
uniprot id: A0A376E5T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS03840
gene id: 1074000:AFK65_RS03840
uniprot id: A0A376E1X3
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1074000:AFK65 RS14420
gene id: 1074000:AFK65_RS14420
uniprot id: A0A376EQM7
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS12745
gene id: 1074000:AFK65_RS12745
uniprot id: A0A376ENL8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
messages: Homodimer.

1074000:AFK65 RS13305
gene id: 1074000:AFK65_RS13305
uniprot id: A0A376ENA9
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

1074000:AFK65 RS06110
gene id: 1074000:AFK65_RS06110
uniprot id: A0A376E5F0
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

1074000:AFK65 RS00085
gene id: 1074000:AFK65_RS00085
uniprot id: A0A376DWI5
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1074000:AFK65 RS02240
gene id: 1074000:AFK65_RS02240
uniprot id: A0A376DZ28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiU subfamily.
messages: Forms an heterodimer with UbiV.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

1074000:AFK65 RS19375
gene id: 1074000:AFK65_RS19375
uniprot id: A0A376F1D3
names: Similarity
messages: Belongs to the UPF0758 family. YicR subfamily.

1074000:AFK65 RS05600
gene id: 1074000:AFK65_RS05600
uniprot id: A0A376E4L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1074000:AFK65 RS04005
gene id: 1074000:AFK65_RS04005
uniprot id: A0A376E246
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1074000:AFK65 RS07825
gene id: 1074000:AFK65_RS07825
uniprot id: A0A376EAP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YkuD family.
messages: Periplasm

1074000:AFK65 RS19835
gene id: 1074000:AFK65_RS19835
uniprot id: A0A376F0A5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1074000:AFK65 RS05320
gene id: 1074000:AFK65_RS05320
uniprot id: A0A376E5C2
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1074000:AFK65 RS01950
gene id: 1074000:AFK65_RS01950
uniprot id: A0A376DYN6
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1074000:AFK65 RS16510
gene id: 1074000:AFK65_RS16510
uniprot id: A0A376EYL6
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

1074000:AFK65 RS17995
gene id: 1074000:AFK65_RS17995
uniprot id: A0A0K2MYQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1074000:AFK65 RS11110
gene id: 1074000:AFK65_RS11110
uniprot id: A0A376EK87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0259 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS03885
gene id: 1074000:AFK65_RS03885
uniprot id: A0A376E3F0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 1 iron-sulfur cluster per subunit.
messages: Homodimer.
messages: Required for insertion of 4Fe-4S clusters for at least IspG.

1074000:AFK65 RS13145
gene id: 1074000:AFK65_RS13145
uniprot id: A0A376EQ77
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS18550
gene id: 1074000:AFK65_RS18550
uniprot id: A0A376F0Y7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1074000:AFK65 RS03230
gene id: 1074000:AFK65_RS03230
uniprot id: A0A376E0V1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1074000:AFK65 RS05830
gene id: 1074000:AFK65_RS05830
uniprot id: A0A376E5C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS01815
gene id: 1074000:AFK65_RS01815
uniprot id: A0A376DYH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1074000:AFK65 RS16260
gene id: 1074000:AFK65_RS16260
uniprot id: A0A376EXL0
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
messages: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytidylyltransferase family.
messages: In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

1074000:AFK65 RS18335
gene id: 1074000:AFK65_RS18335
uniprot id: A0A376EYL3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NfuA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is presumably bound at the interface of two monomers.
messages: Homodimer.
messages: Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.

1074000:AFK65 RS16975
gene id: 1074000:AFK65_RS16975
uniprot id: A0A376EYE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TamA family.
messages: Cell outer membrane
messages: Membrane

1074000:AFK65 RS10140
gene id: 1074000:AFK65_RS10140
uniprot id: A0A376EFU7
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1074000:AFK65 RS03535
gene id: 1074000:AFK65_RS03535
uniprot id: A0A376E286
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1074000:AFK65 RS07305
gene id: 1074000:AFK65_RS07305
uniprot id: A0A376EAW6
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.

1074000:AFK65 RS13670
gene id: 1074000:AFK65_RS13670
uniprot id: A0A376EPQ4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS01595
gene id: 1074000:AFK65_RS01595
uniprot id: A0A376DYB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1074000:AFK65 RS12160
gene id: 1074000:AFK65_RS12160
uniprot id: A0A376EME4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyltransferase 20 family.
messages: Homotetramer.
messages: Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-alpha-D-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor.

1074000:AFK65 RS14320
gene id: 1074000:AFK65_RS14320
uniprot id: A0A376ERY7
names: Similarity
messages: Belongs to the isochorismate synthase family.

1074000:AFK65 RS10935
gene id: 1074000:AFK65_RS10935
uniprot id: A0A376EIT4
names: Function
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.
messages: Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.

1074000:AFK65 RS12985
gene id: 1074000:AFK65_RS12985
uniprot id: A0A376EPV9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily.
messages: Cell inner membrane
messages: Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtC forms a heteromultimer with MdtB.

1074000:AFK65 RS03390
gene id: 1074000:AFK65_RS03390
uniprot id: A0A376E203
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefC subfamily.
messages: Cell inner membrane
messages: Homodimer. Interacts with the regulatory subunit KefF.
messages: Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport.

1074000:AFK65 RS06400
gene id: 1074000:AFK65_RS06400
uniprot id: A0A376E6Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS14190
gene id: 1074000:AFK65_RS14190
uniprot id: A0A376EPM6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

1074000:AFK65 RS04630
gene id: 1074000:AFK65_RS04630
uniprot id: A0A376E5D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

1074000:AFK65 RS09060
gene id: 1074000:AFK65_RS09060
uniprot id: A0A376ECA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1074000:AFK65 RS01745
gene id: 1074000:AFK65_RS01745
uniprot id: A0A376DYD0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1074000:AFK65 RS03780
gene id: 1074000:AFK65_RS03780
uniprot id: A0A376E1P7
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

1074000:AFK65 RS01015
gene id: 1074000:AFK65_RS01015
uniprot id: A0A376DXG6
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS14755
gene id: 1074000:AFK65_RS14755
uniprot id: A0A376ETA6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: In the C-terminal section; belongs to the transglycosylase Slt family.
messages: In the N-terminal section; belongs to the bacterial solute-binding protein 3 family.
messages: Membrane
messages: Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
messages: The N-terminal domain does not have lytic activity and probably modulates enzymatic activity. The C-terminal domain is the catalytic active domain.

1074000:AFK65 RS13995
gene id: 1074000:AFK65_RS13995
uniprot id: A0A376EP92
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1074000:AFK65 RS11080
gene id: 1074000:AFK65_RS11080
uniprot id: A0A376EJ57
names: Function
names: Similarity
messages: Belongs to the TrpC family.
messages: Belongs to the TrpF family.
messages: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain.
messages: In the C-terminal section; belongs to the TrpF family.
messages: In the N-terminal section; belongs to the TrpC family.

1074000:AFK65 RS17950
gene id: 1074000:AFK65_RS17950
uniprot id: A0A376F092
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1074000:AFK65 RS03310
gene id: 1074000:AFK65_RS03310
uniprot id: A0A376E2F2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS12305
gene id: 1074000:AFK65_RS12305
uniprot id: A0A376EMQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.
messages: Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine.
messages: Homodimer.

1074000:AFK65 RS18195
gene id: 1074000:AFK65_RS18195
uniprot id: A0A376F043
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1074000:AFK65 RS06330
gene id: 1074000:AFK65_RS06330
uniprot id: A0A376E7D1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS00840
gene id: 1074000:AFK65_RS00840
uniprot id: A0A376DX42
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1074000:AFK65 RS10195
gene id: 1074000:AFK65_RS10195
uniprot id: A0A376EH49
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1074000:AFK65 RS19975
gene id: 1074000:AFK65_RS19975
uniprot id: A0A376KQT2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS17915
gene id: 1074000:AFK65_RS17915
uniprot id: A0A376EY44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1074000:AFK65 RS13750
gene id: 1074000:AFK65_RS13750
uniprot id: A0A376EQI8
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

1074000:AFK65 RS08790
gene id: 1074000:AFK65_RS08790
uniprot id: A0A376ED99
names: Function
names: Similarity
messages: Belongs to the GMC oxidoreductase family.
messages: Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.

1074000:AFK65 RS00015
gene id: 1074000:AFK65_RS00015
uniprot id: A0A376DWE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1074000:AFK65 RS15740
gene id: 1074000:AFK65_RS15740
uniprot id: A0A376EUT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1074000:AFK65 RS08785
gene id: 1074000:AFK65_RS08785
uniprot id: A0A376ED93
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS17225
gene id: 1074000:AFK65_RS17225
uniprot id: A0A376EYA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

1074000:AFK65 RS17900
gene id: 1074000:AFK65_RS17900
uniprot id: A0A376EZR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1074000:AFK65 RS04250
gene id: 1074000:AFK65_RS04250
uniprot id: A0A376E2Q8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gram-negative porin family.
messages: Cell outer membrane
messages: Homotrimer.
messages: Membrane

1074000:AFK65 RS03125
gene id: 1074000:AFK65_RS03125
uniprot id: A0A376E1M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

1074000:AFK65 RS04925
gene id: 1074000:AFK65_RS04925
uniprot id: A0A376E3X9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1074000:AFK65 RS12145
gene id: 1074000:AFK65_RS12145
uniprot id: A0A376EMD4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FlhC family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
messages: Heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.

1074000:AFK65 RS15395
gene id: 1074000:AFK65_RS15395
uniprot id: A0A376EUF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Homodimer.

1074000:AFK65 RS00560
gene id: 1074000:AFK65_RS00560
uniprot id: A0A376DXD7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the rhamnose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
messages: Cytoplasm
messages: Homotetramer.

1074000:AFK65 RS15935
gene id: 1074000:AFK65_RS15935
uniprot id: A0A376ETU4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1074000:AFK65 RS10845
gene id: 1074000:AFK65_RS10845
uniprot id: A0A376EHP6
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

1074000:AFK65 RS10370
gene id: 1074000:AFK65_RS10370
uniprot id: A0A376EFX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0060 family.
messages: Cell membrane

1074000:AFK65 RS05800
gene id: 1074000:AFK65_RS05800
uniprot id: A0A376E4Y1
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1074000:AFK65 RS07630
gene id: 1074000:AFK65_RS07630
uniprot id: A0A376EA78
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

1074000:AFK65 RS00010
gene id: 1074000:AFK65_RS00010
uniprot id: A0A376DVH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1074000:AFK65 RS19705
gene id: 1074000:AFK65_RS19705
uniprot id: A0A376F2Y7
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS06025
gene id: 1074000:AFK65_RS06025
uniprot id: A0A376E587
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1074000:AFK65 RS09165
gene id: 1074000:AFK65_RS09165
uniprot id: A0A376EE16
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1074000:AFK65 RS13330
gene id: 1074000:AFK65_RS13330
uniprot id: A0A376EMM6
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS19980
gene id: 1074000:AFK65_RS19980
uniprot id: A0A376KPS7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS08755
gene id: 1074000:AFK65_RS08755
uniprot id: A0A376ED19
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS20160
gene id: 1074000:AFK65_RS20160
uniprot id: A0A376KPX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

1074000:AFK65 RS20040
gene id: 1074000:AFK65_RS20040
uniprot id: A0A376KRX5
names: Function
names: Subunit
messages: Homodimer.
messages: Required for resistance to the phenazine antibiotic.

1074000:AFK65 RS02040
gene id: 1074000:AFK65_RS02040
uniprot id: A0A376E093
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.
messages: Homotetramer.

1074000:AFK65 RS11345
gene id: 1074000:AFK65_RS11345
uniprot id: A0A376EII0
names: Similarity
messages: Belongs to the CmpA/NrtA family.

1074000:AFK65 RS13260
gene id: 1074000:AFK65_RS13260
uniprot id: A0A376EMV8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

1074000:AFK65 RS16210
gene id: 1074000:AFK65_RS16210
uniprot id: A0A376EWC0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase class-III family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.

1074000:AFK65 RS04555
gene id: 1074000:AFK65_RS04555
uniprot id: A0A376E3B3
names: Similarity
messages: Belongs to the bacterial PQQ dehydrogenase family.

1074000:AFK65 RS20095
gene id: 1074000:AFK65_RS20095
uniprot id: A0A376KPY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPS (TC 1.B.20) family.
messages: Cell outer membrane
messages: Membrane

1074000:AFK65 RS18215
gene id: 1074000:AFK65_RS18215
uniprot id: A0A376EZR0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

1074000:AFK65 RS11260
gene id: 1074000:AFK65_RS11260
uniprot id: A0A376EKI4
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS17205
gene id: 1074000:AFK65_RS17205
uniprot id: A0A376EYL4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueG family.
messages: Binds 2 [4Fe-4S] clusters per monomer.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1074000:AFK65 RS12945
gene id: 1074000:AFK65_RS12945
uniprot id: A0A376EP81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

1074000:AFK65 RS15500
gene id: 1074000:AFK65_RS15500
uniprot id: A0A376EVQ0
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1074000:AFK65 RS07930
gene id: 1074000:AFK65_RS07930
uniprot id: A0A376EAW8
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1074000:AFK65 RS18785
gene id: 1074000:AFK65_RS18785
uniprot id: A0A376EY84
names: Function
messages: Required for maximal bacterial cellulose synthesis.

1074000:AFK65 RS11775
gene id: 1074000:AFK65_RS11775
uniprot id: A0A376EIP7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS17870
gene id: 1074000:AFK65_RS17870
uniprot id: A0A376F0U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1074000:AFK65 RS13780
gene id: 1074000:AFK65_RS13780
uniprot id: A0A376ENR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Periplasm

1074000:AFK65 RS04085
gene id: 1074000:AFK65_RS04085
uniprot id: A0A376E3P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

1074000:AFK65 RS14605
gene id: 1074000:AFK65_RS14605
uniprot id: A0A376ES29
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

1074000:AFK65 RS10820
gene id: 1074000:AFK65_RS10820
uniprot id: A0A376EIG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0283 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS15210
gene id: 1074000:AFK65_RS15210
uniprot id: A0A376ETX0
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.

1074000:AFK65 RS14500
gene id: 1074000:AFK65_RS14500
uniprot id: A0A376EQF2
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS10270
gene id: 1074000:AFK65_RS10270
uniprot id: A0A376EHB1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS01585
gene id: 1074000:AFK65_RS01585
uniprot id: A0A376DZ41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.
messages: Protein L10 is also a translational repressor protein. It controls the translation of the rplJL-rpoBC operon by binding to its mRNA.

1074000:AFK65 RS05120
gene id: 1074000:AFK65_RS05120
uniprot id: A0A376E3T2
names: Similarity
messages: Belongs to the P(II) protein family.

1074000:AFK65 RS12010
gene id: 1074000:AFK65_RS12010
uniprot id: A0A376EM26
names: Similarity
messages: Belongs to the heat shock protein 70 family.

1074000:AFK65 RS13880
gene id: 1074000:AFK65_RS13880
uniprot id: A0A376EPS0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M74 family.
messages: Binds 2 Zn(2+) ions per subunit. Zn(2+) ion 1 is bound in the active site. Zn(2+) ion 2 is bound at the dimer interface by residues from both subunits.
messages: Dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Murein endopeptidase that cleaves the D-alanyl-meso-2,6-diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus.
messages: Periplasm

1074000:AFK65 RS11890
gene id: 1074000:AFK65_RS11890
uniprot id: A0A376ELS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

1074000:AFK65 RS20350
gene id: 1074000:AFK65_RS20350
uniprot id: A0A376KRV5
names: Similarity
messages: Belongs to the DapA family.

1074000:AFK65 RS16485
gene id: 1074000:AFK65_RS16485
uniprot id: A0A376EVV0
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

1074000:AFK65 RS02840
gene id: 1074000:AFK65_RS02840
uniprot id: A0A376E1B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS03575
gene id: 1074000:AFK65_RS03575
uniprot id: A0A376E2S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS17660
gene id: 1074000:AFK65_RS17660
uniprot id: A0A376EZI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1074000:AFK65 RS07400
gene id: 1074000:AFK65_RS07400
uniprot id: A0A376E8A2
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1074000:AFK65 RS11715
gene id: 1074000:AFK65_RS11715
uniprot id: A0A376EKE7
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.
messages: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

1074000:AFK65 RS00110
gene id: 1074000:AFK65_RS00110
uniprot id: A0A376DXT7
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS05765
gene id: 1074000:AFK65_RS05765
uniprot id: A0A376E780
names: Similarity
messages: Belongs to the UPF0250 family.

1074000:AFK65 RS19175
gene id: 1074000:AFK65_RS19175
uniprot id: A0A376F156
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS16680
gene id: 1074000:AFK65_RS16680
uniprot id: A0A376EXD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the porin LamB (TC 1.B.3) family.
messages: Membrane

1074000:AFK65 RS11825
gene id: 1074000:AFK65_RS11825
uniprot id: A0A376ELA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.

1074000:AFK65 RS06565
gene id: 1074000:AFK65_RS06565
uniprot id: A0A376E765
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

1074000:AFK65 RS13500
gene id: 1074000:AFK65_RS13500
uniprot id: A0A376END8
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1074000:AFK65 RS01385
gene id: 1074000:AFK65_RS01385
uniprot id: A0A376DXY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LysR transcriptional regulatory family.
messages: Cytoplasm

1074000:AFK65 RS12485
gene id: 1074000:AFK65_RS12485
uniprot id: A0A376EKU7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliO/MopB family.
messages: Cell membrane

1074000:AFK65 RS04345
gene id: 1074000:AFK65_RS04345
uniprot id: A0A376E2K7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PqqD family.
messages: Functions as a PqqA binding protein and presents PqqA to PqqE, in the pyrroloquinoline quinone (PQQ) biosynthetic pathway.
messages: Monomer. Interacts with PqqE.

1074000:AFK65 RS07255
gene id: 1074000:AFK65_RS07255
uniprot id: A0A376E818
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dsrC/tusE family.
messages: Cytoplasm
messages: Interacts with the TusBCD complex. Interacts with MnmA.
messages: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Could accept sulfur from TusD.

1074000:AFK65 RS04140
gene id: 1074000:AFK65_RS04140
uniprot id: A0A376E2K1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS08385
gene id: 1074000:AFK65_RS08385
uniprot id: A0A376EC13
names: Similarity
messages: Belongs to the protease inhibitor I11 (ecotin) family.

1074000:AFK65 RS08350
gene id: 1074000:AFK65_RS08350
uniprot id: A0A376EB37
names: Similarity
messages: Belongs to the fructosamine kinase family.

1074000:AFK65 RS00865
gene id: 1074000:AFK65_RS00865
uniprot id: A0A376DX34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

1074000:AFK65 RS07860
gene id: 1074000:AFK65_RS07860
uniprot id: A0A376EB75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine.

1074000:AFK65 RS18625
gene id: 1074000:AFK65_RS18625
uniprot id: A0A376F121
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1074000:AFK65 RS16125
gene id: 1074000:AFK65_RS16125
uniprot id: A0A376EUE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsP family.
messages: Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress.
messages: Periplasm

1074000:AFK65 RS04670
gene id: 1074000:AFK65_RS04670
uniprot id: A0A376E4Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS08145
gene id: 1074000:AFK65_RS08145
uniprot id: A0A376EAL3
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS18495
gene id: 1074000:AFK65_RS18495
uniprot id: A0A376F027
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

1074000:AFK65 RS07575
gene id: 1074000:AFK65_RS07575
uniprot id: A0A376E8Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS12025
gene id: 1074000:AFK65_RS12025
uniprot id: A0A376ELV2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1074000:AFK65 RS05750
gene id: 1074000:AFK65_RS05750
uniprot id: A0A376E5D7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1074000:AFK65 RS11750
gene id: 1074000:AFK65_RS11750
uniprot id: A0A376EIJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0266 family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS01785
gene id: 1074000:AFK65_RS01785
uniprot id: A0A376DYQ1
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

1074000:AFK65 RS06270
gene id: 1074000:AFK65_RS06270
uniprot id: A0A376E8E1
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

1074000:AFK65 RS07080
gene id: 1074000:AFK65_RS07080
uniprot id: A0A376E8C1
names: Similarity
messages: Belongs to the YkuD family.

1074000:AFK65 RS07380
gene id: 1074000:AFK65_RS07380
uniprot id: A0A376E9T4
names: Function
names: Similarity
messages: Belongs to the EfeM/EfeO family.
messages: Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component.

1074000:AFK65 RS06490
gene id: 1074000:AFK65_RS06490
uniprot id: A0A376E6F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS03815
gene id: 1074000:AFK65_RS03815
uniprot id: A0A376E1S0
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

1074000:AFK65 RS04940
gene id: 1074000:AFK65_RS04940
uniprot id: A0A376E5X4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

1074000:AFK65 RS01280
gene id: 1074000:AFK65_RS01280
uniprot id: A0A376DXS9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1074000:AFK65 RS12275
gene id: 1074000:AFK65_RS12275
uniprot id: A0A376EKJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1074000:AFK65 RS04050
gene id: 1074000:AFK65_RS04050
uniprot id: A0A376E343
names: Similarity
messages: Belongs to the UPF0253 family.

1074000:AFK65 RS11225
gene id: 1074000:AFK65_RS11225
uniprot id: A0A376EHM2
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the RssB family.
messages: Binds to RpoS.
messages: Phosphorylated. Phosphorylation stimulates the interaction with RpoS and, therefore, the proteolysis of RpoS.
messages: Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co-degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation.

1074000:AFK65 RS13590
gene id: 1074000:AFK65_RS13590
uniprot id: A0A376ENA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ElaB/YgaM/YqjD family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS13630
gene id: 1074000:AFK65_RS13630
uniprot id: A0A376ENP0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1074000:AFK65 RS14555
gene id: 1074000:AFK65_RS14555
uniprot id: A0A376EQY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamB family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

1074000:AFK65 RS12720
gene id: 1074000:AFK65_RS12720
uniprot id: A0A376EMJ1
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS08490
gene id: 1074000:AFK65_RS08490
uniprot id: A0A376EAZ8
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.

1074000:AFK65 RS06505
gene id: 1074000:AFK65_RS06505
uniprot id: A0A376E894
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: Cytoplasm
messages: During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction.
messages: Homododecamer. The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe(3+) can be deposited.

1074000:AFK65 RS01450
gene id: 1074000:AFK65_RS01450
uniprot id: A0A376DY44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RfaH family.
messages: Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains.
messages: Interacts with both the nontemplate DNA and the RNA polymerase (RNAP).

1074000:AFK65 RS18560
gene id: 1074000:AFK65_RS18560
uniprot id: A0A376F1P2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

1074000:AFK65 RS12605
gene id: 1074000:AFK65_RS12605
uniprot id: A0A376ENC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS01895
gene id: 1074000:AFK65_RS01895
uniprot id: A0A376DYK0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1074000:AFK65 RS03600
gene id: 1074000:AFK65_RS03600
uniprot id: A0A376E1B9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1074000:AFK65 RS17845
gene id: 1074000:AFK65_RS17845
uniprot id: A0A376EZB0
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1074000:AFK65 RS12775
gene id: 1074000:AFK65_RS12775
uniprot id: A0A376EMN0
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

1074000:AFK65 RS01615
gene id: 1074000:AFK65_RS01615
uniprot id: A0A376E0C0
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

1074000:AFK65 RS06180
gene id: 1074000:AFK65_RS06180
uniprot id: A0A376E673
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

1074000:AFK65 RS00540
gene id: 1074000:AFK65_RS00540
uniprot id: A0A376DXC3
names: Similarity
messages: Belongs to the glycosyl hydrolase.

1074000:AFK65 RS17690
gene id: 1074000:AFK65_RS17690
uniprot id: A0A376EX25
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS03250
gene id: 1074000:AFK65_RS03250
uniprot id: A0A376E0U3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1074000:AFK65 RS01940
gene id: 1074000:AFK65_RS01940
uniprot id: A0A376DYX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AFG1 ATPase family. ZapE subfamily.
messages: Cytoplasm
messages: Interacts with FtsZ.
messages: Reduces the stability of FtsZ polymers in the presence of ATP.

1074000:AFK65 RS06130
gene id: 1074000:AFK65_RS06130
uniprot id: A0A376E815
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1074000:AFK65 RS08925
gene id: 1074000:AFK65_RS08925
uniprot id: A0A376EDZ3
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.
messages: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters.

1074000:AFK65 RS15140
gene id: 1074000:AFK65_RS15140
uniprot id: A0A376ERU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ElaB/YgaM/YqjD family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS00755
gene id: 1074000:AFK65_RS00755
uniprot id: A0A376DXS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

1074000:AFK65 RS01470
gene id: 1074000:AFK65_RS01470
uniprot id: A0A376E073
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
messages: Cytoplasm
messages: Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).

1074000:AFK65 RS14310
gene id: 1074000:AFK65_RS14310
uniprot id: A0A376EPY7
names: Cofactor
messages: Binds 1 phosphopantetheine covalently.

1074000:AFK65 RS11390
gene id: 1074000:AFK65_RS11390
uniprot id: A0A376EIM7
names: Similarity
messages: Belongs to the UPF0162 family.

1074000:AFK65 RS15760
gene id: 1074000:AFK65_RS15760
uniprot id: A0A376EU08
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS00650
gene id: 1074000:AFK65_RS00650
uniprot id: A0A376DWL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

1074000:AFK65 RS00420
gene id: 1074000:AFK65_RS00420
uniprot id: A0A376DWA3
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

1074000:AFK65 RS07905
gene id: 1074000:AFK65_RS07905
uniprot id: A0A376E9E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HflD family.
messages: Cell membrane
messages: Cytoplasm

1074000:AFK65 RS17825
gene id: 1074000:AFK65_RS17825
uniprot id: A0A376EZA3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS04845
gene id: 1074000:AFK65_RS04845
uniprot id: A0A376E3T1
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS07325
gene id: 1074000:AFK65_RS07325
uniprot id: A0A376E883
names: Function
names: Similarity
messages: Belongs to the nitroreductase family. HadB/RutE subfamily.
messages: May reduce toxic product malonic semialdehyde to 3-hydroxypropionic acid, which is excreted.

1074000:AFK65 RS13575
gene id: 1074000:AFK65_RS13575
uniprot id: A0A376EQP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MenH family.
messages: Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
messages: Monomer.

1074000:AFK65 RS13960
gene id: 1074000:AFK65_RS13960
uniprot id: A0A376ERR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

1074000:AFK65 RS00350
gene id: 1074000:AFK65_RS00350
uniprot id: A0A376DW37
names: Similarity
messages: Belongs to the VgrG protein family.

1074000:AFK65 RS01525
gene id: 1074000:AFK65_RS01525
uniprot id: A0A376DY71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1074000:AFK65 RS00890
gene id: 1074000:AFK65_RS00890
uniprot id: A0A376DY24
names: Function
names: Similarity
messages: Belongs to the GppA/Ppx family. GppA subfamily.
messages: Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.

1074000:AFK65 RS05470
gene id: 1074000:AFK65_RS05470
uniprot id: A0A376E616
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS10490
gene id: 1074000:AFK65_RS10490
uniprot id: A0A376EHQ1
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

1074000:AFK65 RS11900
gene id: 1074000:AFK65_RS11900
uniprot id: A0A376EMH8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.

1074000:AFK65 RS13255
gene id: 1074000:AFK65_RS13255
uniprot id: A0A376EPX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

1074000:AFK65 RS02190
gene id: 1074000:AFK65_RS02190
uniprot id: A0A376DYZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1074000:AFK65 RS01475
gene id: 1074000:AFK65_RS01475
uniprot id: A0A376DYE0
names: Function
names: Similarity
names: Subunit
messages: Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).
messages: In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
messages: Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.

1074000:AFK65 RS17530
gene id: 1074000:AFK65_RS17530
uniprot id: A0A376EX17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. DnaB subfamily.
messages: Homohexamer.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

1074000:AFK65 RS08185
gene id: 1074000:AFK65_RS08185
uniprot id: A0A376ED33
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.

1074000:AFK65 RS11575
gene id: 1074000:AFK65_RS11575
uniprot id: A0A376EI72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.
messages: Cell membrane
messages: K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.

1074000:AFK65 RS03955
gene id: 1074000:AFK65_RS03955
uniprot id: A0A376E239
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Homodimer.

1074000:AFK65 RS17785
gene id: 1074000:AFK65_RS17785
uniprot id: A0A376EX56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

1074000:AFK65 RS13615
gene id: 1074000:AFK65_RS13615
uniprot id: A0A376EQT1
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS13140
gene id: 1074000:AFK65_RS13140
uniprot id: A0A376EP63
names: Similarity
messages: Belongs to the peptidase S11 family.

1074000:AFK65 RS01730
gene id: 1074000:AFK65_RS01730
uniprot id: A0A376DZB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS20135
gene id: 1074000:AFK65_RS20135
uniprot id: A0A376KS31
names: Similarity
messages: Belongs to the IucA/IucC family.

1074000:AFK65 RS00910
gene id: 1074000:AFK65_RS00910
uniprot id: A0A376DXH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. WecA subfamily.
messages: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS11015
gene id: 1074000:AFK65_RS11015
uniprot id: A0A376EIZ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: Homodimer.

1074000:AFK65 RS13955
gene id: 1074000:AFK65_RS13955
uniprot id: A0A376ER45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmD/CycX/HelD family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

1074000:AFK65 RS16945
gene id: 1074000:AFK65_RS16945
uniprot id: A0A376EVV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

1074000:AFK65 RS06605
gene id: 1074000:AFK65_RS06605
uniprot id: A0A376E6M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS05285
gene id: 1074000:AFK65_RS05285
uniprot id: A0A376E4J9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1074000:AFK65 RS15905
gene id: 1074000:AFK65_RS15905
uniprot id: A0A376ETR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

1074000:AFK65 RS02185
gene id: 1074000:AFK65_RS02185
uniprot id: A0A376E138
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1074000:AFK65 RS03485
gene id: 1074000:AFK65_RS03485
uniprot id: A0A376E1F0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane
messages: The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).

1074000:AFK65 RS12595
gene id: 1074000:AFK65_RS12595
uniprot id: A0A376EL50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtfA family.
messages: Cytoplasm
messages: Interacts with Mlc.
messages: Involved in the regulation of ptsG expression by binding and inactivating Mlc.

1074000:AFK65 RS13585
gene id: 1074000:AFK65_RS13585
uniprot id: A0A376EP16
names: Function
names: Similarity
messages: Belongs to the isochorismate synthase family.
messages: Catalyzes the conversion of chorismate to isochorismate.

1074000:AFK65 RS20385
gene id: 1074000:AFK65_RS20385
uniprot id: A0A376KQ34
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

1074000:AFK65 RS14060
gene id: 1074000:AFK65_RS14060
uniprot id: A0A376ESG0
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

1074000:AFK65 RS04035
gene id: 1074000:AFK65_RS04035
uniprot id: A0A376E2E8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

1074000:AFK65 RS11585
gene id: 1074000:AFK65_RS11585
uniprot id: A0A376EJ58
names: Function
names: Similarity
messages: Belongs to the DadA oxidoreductase family.
messages: Oxidative deamination of D-amino acids.

1074000:AFK65 RS15445
gene id: 1074000:AFK65_RS15445
uniprot id: A0A376EVJ4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.
messages: Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 FMN per subunit.
messages: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS15130
gene id: 1074000:AFK65_RS15130
uniprot id: A0A376ES87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AlaE exporter family.
messages: Cell inner membrane
messages: Exports L-alanine.

1074000:AFK65 RS13300
gene id: 1074000:AFK65_RS13300
uniprot id: A0A376ENV1
names: Similarity
messages: Belongs to the elongation factor P family.

1074000:AFK65 RS20120
gene id: 1074000:AFK65_RS20120
uniprot id: A0A376KPY8
names: Similarity
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.

1074000:AFK65 RS11030
gene id: 1074000:AFK65_RS11030
uniprot id: A0A376EJ80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1074000:AFK65 RS08250
gene id: 1074000:AFK65_RS08250
uniprot id: A0A376EAF8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in both the arginine and lysine biosynthetic pathways.

1074000:AFK65 RS18135
gene id: 1074000:AFK65_RS18135
uniprot id: A0A376EXQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TsgA family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS12415
gene id: 1074000:AFK65_RS12415
uniprot id: A0A376ENM1
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

1074000:AFK65 RS08975
gene id: 1074000:AFK65_RS08975
uniprot id: A0A376EC23
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1074000:AFK65 RS19405
gene id: 1074000:AFK65_RS19405
uniprot id: A0A376EYV4
names: Similarity
messages: Belongs to the YicC/YloC family.

1074000:AFK65 RS00095
gene id: 1074000:AFK65_RS00095
uniprot id: A0A376DX55
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS08430
gene id: 1074000:AFK65_RS08430
uniprot id: A0A376EAU5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1074000:AFK65 RS11950
gene id: 1074000:AFK65_RS11950
uniprot id: A0A376EKH9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1074000:AFK65 RS16170
gene id: 1074000:AFK65_RS16170
uniprot id: A0A376EXD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS18440
gene id: 1074000:AFK65_RS18440
uniprot id: A0A376EYQ8
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

1074000:AFK65 RS17970
gene id: 1074000:AFK65_RS17970
uniprot id: A0A376EZF0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1074000:AFK65 RS19460
gene id: 1074000:AFK65_RS19460
uniprot id: A0A376EYW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Membrane

1074000:AFK65 RS02905
gene id: 1074000:AFK65_RS02905
uniprot id: A0A376E215
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

1074000:AFK65 RS05290
gene id: 1074000:AFK65_RS05290
uniprot id: A0A376E5P9
names: Similarity
messages: Belongs to the CdaR family.

1074000:AFK65 RS07095
gene id: 1074000:AFK65_RS07095
uniprot id: A0A376E8M1
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

1074000:AFK65 RS08420
gene id: 1074000:AFK65_RS08420
uniprot id: A0A376EBB8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1074000:AFK65 RS13505
gene id: 1074000:AFK65_RS13505
uniprot id: A0A376ER01
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

1074000:AFK65 RS10135
gene id: 1074000:AFK65_RS10135
uniprot id: A0A376EFA9
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS05835
gene id: 1074000:AFK65_RS05835
uniprot id: A0A376E664
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS09155
gene id: 1074000:AFK65_RS09155
uniprot id: A0A376EE35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
messages: Membrane

1074000:AFK65 RS06800
gene id: 1074000:AFK65_RS06800
uniprot id: A0A376E714
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS02045
gene id: 1074000:AFK65_RS02045
uniprot id: A0A376DYT5
names: Similarity
names: Subunit
messages: Belongs to the SIS family. GutQ/KpsF subfamily.
messages: Homotetramer.

1074000:AFK65 RS19720
gene id: 1074000:AFK65_RS19720
uniprot id: A0A376F1R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Responsible for the low-affinity transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

1074000:AFK65 RS17945
gene id: 1074000:AFK65_RS17945
uniprot id: A0A376EZE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1074000:AFK65 RS18600
gene id: 1074000:AFK65_RS18600
uniprot id: A0A376F114
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS13360
gene id: 1074000:AFK65_RS13360
uniprot id: A0A376EN40
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1074000:AFK65 RS04355
gene id: 1074000:AFK65_RS04355
uniprot id: A0A376E3L7
names: Function
names: Similarity
messages: Belongs to the PqqB family.
messages: May be involved in the transport of PQQ or its precursor to the periplasm.

1074000:AFK65 RS02820
gene id: 1074000:AFK65_RS02820
uniprot id: A0A376E0B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SymE family.
messages: Cytoplasm
messages: Involved in the degradation and recycling of damaged RNA. It is itself a target for degradation by the ATP-dependent protease Lon.

1074000:AFK65 RS14875
gene id: 1074000:AFK65_RS14875
uniprot id: A0A376ER63
names: Similarity
messages: Belongs to the thioredoxin family.

1074000:AFK65 RS03915
gene id: 1074000:AFK65_RS03915
uniprot id: A0A376E212
names: Similarity
messages: Belongs to the UPF0325 family.

1074000:AFK65 RS10565
gene id: 1074000:AFK65_RS10565
uniprot id: A0A376EHW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS11520
gene id: 1074000:AFK65_RS11520
uniprot id: A0A376EIT6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 37 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Periplasm
messages: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.

1074000:AFK65 RS03520
gene id: 1074000:AFK65_RS03520
uniprot id: A0A376E176
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homodimer.

1074000:AFK65 RS12070
gene id: 1074000:AFK65_RS12070
uniprot id: A0A376EK77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

1074000:AFK65 RS14655
gene id: 1074000:AFK65_RS14655
uniprot id: A0A376ETG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HscB family.
messages: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.
messages: Interacts with HscA and stimulates its ATPase activity. Interacts with IscU.

1074000:AFK65 RS04965
gene id: 1074000:AFK65_RS04965
uniprot id: A0A376E3H5
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1074000:AFK65 RS06430
gene id: 1074000:AFK65_RS06430
uniprot id: A0A376E7P1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the helicase family. DinG subfamily. Type 1 sub-subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA-dependent ATPase and 5'-3' DNA helicase.

1074000:AFK65 RS18620
gene id: 1074000:AFK65_RS18620
uniprot id: A0A376F084
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfur carrier protein TusA family.
messages: Cytoplasm
messages: Interacts with IscS.
messages: Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.

1074000:AFK65 RS08220
gene id: 1074000:AFK65_RS08220
uniprot id: A0A376EBU9
names: Cofactor
names: Similarity
messages: Belongs to the nitroreductase family.
messages: Binds 1 FMN per subunit.

1074000:AFK65 RS17165
gene id: 1074000:AFK65_RS17165
uniprot id: A0A376EYI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

1074000:AFK65 RS15035
gene id: 1074000:AFK65_RS15035
uniprot id: A0A376ESX1
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS11170
gene id: 1074000:AFK65_RS11170
uniprot id: A0A376EHJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS03435
gene id: 1074000:AFK65_RS03435
uniprot id: A0A376E127
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Homodimer.
messages: Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.
messages: The transmembrane domain is a dimerization domain.

1074000:AFK65 RS17195
gene id: 1074000:AFK65_RS17195
uniprot id: A0A376EYB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

1074000:AFK65 RS15700
gene id: 1074000:AFK65_RS15700
uniprot id: A0A376EW19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.
messages: In the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family.
messages: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.

1074000:AFK65 RS12505
gene id: 1074000:AFK65_RS12505
uniprot id: A0A376EMQ0
names: Function
names: Similarity
messages: Belongs to the RcsA family.
messages: Component of the Rcs signaling system, which controls transcription of numerous genes. Binds to DNA to regulate expression of genes.

1074000:AFK65 RS07000
gene id: 1074000:AFK65_RS07000
uniprot id: A0A376E8Y5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

1074000:AFK65 RS13435
gene id: 1074000:AFK65_RS13435
uniprot id: A0A376EQ99
names: Similarity
messages: Belongs to the flavodoxin family.
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

1074000:AFK65 RS00435
gene id: 1074000:AFK65_RS00435
uniprot id: A0A376DWD9
names: Similarity
messages: Belongs to the mannitol dehydrogenase family.

1074000:AFK65 RS11120
gene id: 1074000:AFK65_RS11120
uniprot id: A0A376EHG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1074000:AFK65 RS13805
gene id: 1074000:AFK65_RS13805
uniprot id: A0A376EQ34
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedD family.
messages: Cell inner membrane
messages: Non-essential cell division protein that could be required for efficient cell constriction.
messages: The SPOR domain binds septal peptidoglycans and is required to target DedD to the septal ring.

1074000:AFK65 RS11815
gene id: 1074000:AFK65_RS11815
uniprot id: A0A376EJC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PqiA family.
messages: Component of a transport pathway that contributes to membrane integrity.
messages: Membrane

1074000:AFK65 RS05220
gene id: 1074000:AFK65_RS05220
uniprot id: A0A376E575
names: Similarity
messages: Belongs to the Hha/YmoA/Cnu family.

1074000:AFK65 RS02090
gene id: 1074000:AFK65_RS02090
uniprot id: A0A376DZ04
names: Similarity
messages: Belongs to the ner transcriptional regulatory family.

1074000:AFK65 RS09255
gene id: 1074000:AFK65_RS09255
uniprot id: A0A376EDK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS11040
gene id: 1074000:AFK65_RS11040
uniprot id: A0A376EK36
names: Similarity
messages: Belongs to the peptidase S49 family.

1074000:AFK65 RS06945
gene id: 1074000:AFK65_RS06945
uniprot id: A0A376E7X5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS05605
gene id: 1074000:AFK65_RS05605
uniprot id: A0A376E548
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Fes family.
messages: Cytoplasm

1074000:AFK65 RS02365
gene id: 1074000:AFK65_RS02365
uniprot id: A0A376DZP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the porin LamB (TC 1.B.3) family.
messages: Membrane

1074000:AFK65 RS13925
gene id: 1074000:AFK65_RS13925
uniprot id: A0A376EPW0
names: Similarity
messages: Belongs to the MlaA family.

1074000:AFK65 RS07240
gene id: 1074000:AFK65_RS07240
uniprot id: A0A376E9Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HspQ family.
messages: Cytoplasm
messages: Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.

1074000:AFK65 RS05805
gene id: 1074000:AFK65_RS05805
uniprot id: A0A376E5A3
names: Similarity
messages: Belongs to the DNA polymerase HolA subunit family.

1074000:AFK65 RS10480
gene id: 1074000:AFK65_RS10480
uniprot id: A0A376EIU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS08930
gene id: 1074000:AFK65_RS08930
uniprot id: A0A376ECU3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase T family.
messages: Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.
messages: Homodimer.
messages: Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.

1074000:AFK65 RS06735
gene id: 1074000:AFK65_RS06735
uniprot id: A0A376E7E5
names: Cofactor
names: Similarity
messages: Belongs to the RimK family.
messages: Binds 2 magnesium or manganese ions per subunit.

1074000:AFK65 RS14580
gene id: 1074000:AFK65_RS14580
uniprot id: A0A376ESG2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

1074000:AFK65 RS14165
gene id: 1074000:AFK65_RS14165
uniprot id: A0A376EPM4
names: Subcellular Location Annotation
messages: Cytoplasm

1074000:AFK65 RS17435
gene id: 1074000:AFK65_RS17435
uniprot id: A0A376EYS6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

1074000:AFK65 RS08935
gene id: 1074000:AFK65_RS08935
uniprot id: A0A376ECJ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 nickel ion per subunit.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

1074000:AFK65 RS11600
gene id: 1074000:AFK65_RS11600
uniprot id: A0A376EIB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
messages: Cell membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

1074000:AFK65 RS06570
gene id: 1074000:AFK65_RS06570
uniprot id: A0A376E730
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS19995
gene id: 1074000:AFK65_RS19995
uniprot id: A0A376KRX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS04750
gene id: 1074000:AFK65_RS04750
uniprot id: A0A376E4V4
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS17925
gene id: 1074000:AFK65_RS17925
uniprot id: A0A376EZS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1074000:AFK65 RS06275
gene id: 1074000:AFK65_RS06275
uniprot id: A0A376E5T4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

1074000:AFK65 RS08735
gene id: 1074000:AFK65_RS08735
uniprot id: A0A376EBL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family. RcnA subfamily.
messages: Cell membrane
messages: Efflux system for nickel and cobalt.
messages: Membrane

1074000:AFK65 RS12135
gene id: 1074000:AFK65_RS12135
uniprot id: A0A376EK75
names: Similarity
messages: Belongs to the MotB family.

1074000:AFK65 RS18935
gene id: 1074000:AFK65_RS18935
uniprot id: A0A376EZB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
messages: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS16250
gene id: 1074000:AFK65_RS16250
uniprot id: A0A376EY04
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

1074000:AFK65 RS00545
gene id: 1074000:AFK65_RS00545
uniprot id: A0A376DWG3
names: Subcellular Location Annotation
messages: Cell inner membrane

1074000:AFK65 RS04755
gene id: 1074000:AFK65_RS04755
uniprot id: A0A376E3A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IraP family.
messages: Cytoplasm
messages: Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
messages: Interacts with RssB.

1074000:AFK65 RS11945
gene id: 1074000:AFK65_RS11945
uniprot id: A0A376EKW2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

1074000:AFK65 RS15585
gene id: 1074000:AFK65_RS15585
uniprot id: A0A376ETG4
names: Similarity
messages: Belongs to the SufE family.

1074000:AFK65 RS03280
gene id: 1074000:AFK65_RS03280
uniprot id: A0A376E129
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS05310
gene id: 1074000:AFK65_RS05310
uniprot id: A0A376E6K6
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the phosphorylation of guanosine and inosine to GMP and IMP, respectively.

1074000:AFK65 RS04840
gene id: 1074000:AFK65_RS04840
uniprot id: A0A376E3U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Cell inner membrane
messages: Component of the transport system for branched-chain amino acids.
messages: Membrane

1074000:AFK65 RS05640
gene id: 1074000:AFK65_RS05640
uniprot id: A0A376E5R7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS01070
gene id: 1074000:AFK65_RS01070
uniprot id: A0A376DYW2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS05620
gene id: 1074000:AFK65_RS05620
uniprot id: A0A376E5Q3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds 1 Fe(2+) cation per monomer.
messages: Binds 1 nickel ion per monomer.
messages: Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Monomer.

1074000:AFK65 RS19245
gene id: 1074000:AFK65_RS19245
uniprot id: A0A376F1P8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

1074000:AFK65 RS05125
gene id: 1074000:AFK65_RS05125
uniprot id: A0A376E525
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS15410
gene id: 1074000:AFK65_RS15410
uniprot id: A0A376ESH2
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

1074000:AFK65 RS17735
gene id: 1074000:AFK65_RS17735
uniprot id: A0A376EZL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AceK family.
messages: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
messages: Cytoplasm

1074000:AFK65 RS02025
gene id: 1074000:AFK65_RS02025
uniprot id: A0A376DZQ0
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.

1074000:AFK65 RS13570
gene id: 1074000:AFK65_RS13570
uniprot id: A0A376EQM9
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS04390
gene id: 1074000:AFK65_RS04390
uniprot id: A0A376E4Y5
names: Function
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.

1074000:AFK65 RS08710
gene id: 1074000:AFK65_RS08710
uniprot id: A0A376ED27
names: Function
names: Similarity
messages: Belongs to the GlgS family.
messages: Major determinant of cell surface composition. Negatively regulates motility, adhesion and synthesis of biofilm exopolysaccharides.

1074000:AFK65 RS12405
gene id: 1074000:AFK65_RS12405
uniprot id: A0A376EMM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS17400
gene id: 1074000:AFK65_RS17400
uniprot id: A0A376EZ53
names: Similarity
messages: Belongs to the heat shock protein 90 family.

1074000:AFK65 RS02360
gene id: 1074000:AFK65_RS02360
uniprot id: A0A376DZF4
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS04615
gene id: 1074000:AFK65_RS04615
uniprot id: A0A376E470
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily.
messages: Catalyzes the transfer of an acyl chain from an acyl-[acyl-carrier-protein] (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(acyl)-lipid IV(A).
messages: Cell inner membrane

1074000:AFK65 RS08325
gene id: 1074000:AFK65_RS08325
uniprot id: A0A376EDC5
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS14055
gene id: 1074000:AFK65_RS14055
uniprot id: A0A376EQT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial glucokinase family.
messages: Cytoplasm

1074000:AFK65 RS07855
gene id: 1074000:AFK65_RS07855
uniprot id: A0A376E9P8
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-93 and Arg-96) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase that specifically removes acetyl groups on target proteins. Also acts as a protein-lysine deacylase by mediating protein desuccinylation and de-2-hydroxyisobutyrylation. Modulates the activities of several proteins which are inactive in their acylated form.

1074000:AFK65 RS13130
gene id: 1074000:AFK65_RS13130
uniprot id: A0A376EMK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinone-dependent D-lactate dehydrogenase family.
messages: Catalyzes the oxidation of D-lactate to pyruvate.
messages: Cell inner membrane

1074000:AFK65 RS18640
gene id: 1074000:AFK65_RS18640
uniprot id: A0A376F0I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1074000:AFK65 RS11150
gene id: 1074000:AFK65_RS11150
uniprot id: A0A376EJA4
names: Similarity
messages: Belongs to the UPF0263 family.

1074000:AFK65 RS07950
gene id: 1074000:AFK65_RS07950
uniprot id: A0A376EAJ1
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Member of a two-component regulatory system.

1074000:AFK65 RS01405
gene id: 1074000:AFK65_RS01405
uniprot id: A0A376DXZ8
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

1074000:AFK65 RS05430
gene id: 1074000:AFK65_RS05430
uniprot id: A0A376E4A8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1074000:AFK65 RS17110
gene id: 1074000:AFK65_RS17110
uniprot id: A0A376EZ36
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1074000:AFK65 RS11125
gene id: 1074000:AFK65_RS11125
uniprot id: A0A376EJ46
names: Function
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.
messages: Catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA.

1074000:AFK65 RS15580
gene id: 1074000:AFK65_RS15580
uniprot id: A0A376EUS6
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

1074000:AFK65 RS06340
gene id: 1074000:AFK65_RS06340
uniprot id: A0A376E630
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1074000:AFK65 RS14270
gene id: 1074000:AFK65_RS14270
uniprot id: A0A376EQ97
names: Cofactor
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

1074000:AFK65 RS02215
gene id: 1074000:AFK65_RS02215
uniprot id: A0A376E0H4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer.
messages: May be involved in cell division.

1074000:AFK65 RS04990
gene id: 1074000:AFK65_RS04990
uniprot id: A0A376E405
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

1074000:AFK65 RS07130
gene id: 1074000:AFK65_RS07130
uniprot id: A0A376EAJ7
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the SsuD family.
messages: Catalyzes the desulfonation of aliphatic sulfonates.
messages: FMNH(2) which is absolutely required for this enzymatic reaction, is provided by SsuE.
messages: Homotetramer.

1074000:AFK65 RS02200
gene id: 1074000:AFK65_RS02200
uniprot id: A0A376DZ12
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1074000:AFK65 RS13080
gene id: 1074000:AFK65_RS13080
uniprot id: A0A376EMH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1074000:AFK65 RS18070
gene id: 1074000:AFK65_RS18070
uniprot id: A0A376EZJ4
names: Similarity
messages: Belongs to the NAPRTase family.

1074000:AFK65 RS10615
gene id: 1074000:AFK65_RS10615
uniprot id: A0A376EHZ7
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS14975
gene id: 1074000:AFK65_RS14975
uniprot id: A0A376ESR8
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

1074000:AFK65 RS04135
gene id: 1074000:AFK65_RS04135
uniprot id: A0A376E374
names: Subunit
messages: Monomer.

1074000:AFK65 RS13580
gene id: 1074000:AFK65_RS13580
uniprot id: A0A376EQ40
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

1074000:AFK65 RS15625
gene id: 1074000:AFK65_RS15625
uniprot id: A0A376ESY6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
messages: Belongs to the helicase family. UvrD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.
messages: The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
messages: The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.

1074000:AFK65 RS13455
gene id: 1074000:AFK65_RS13455
uniprot id: A0A376EPS2
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

1074000:AFK65 RS05030
gene id: 1074000:AFK65_RS05030
uniprot id: A0A376E4T9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1074000:AFK65 RS11075
gene id: 1074000:AFK65_RS11075
uniprot id: A0A376EJ24
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS06325
gene id: 1074000:AFK65_RS06325
uniprot id: A0A376E6L1
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.

1074000:AFK65 RS05260
gene id: 1074000:AFK65_RS05260
uniprot id: A0A376E6H9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS19555
gene id: 1074000:AFK65_RS19555
uniprot id: A0A376F219
names: Function
names: Similarity
messages: Belongs to the HIBADH-related family. 3-sulfolactaldehyde reductase subfamily.
messages: Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1-sulfonate (DHPS).

1074000:AFK65 RS01360
gene id: 1074000:AFK65_RS01360
uniprot id: A0A376DZF9
names: Similarity
messages: Belongs to the Rht family.

1074000:AFK65 RS03460
gene id: 1074000:AFK65_RS03460
uniprot id: A0A376E3B8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the arabinose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of L-arabinose to L-ribulose.
messages: Homohexamer.

1074000:AFK65 RS06155
gene id: 1074000:AFK65_RS06155
uniprot id: A0A376E845
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1074000:AFK65 RS03605
gene id: 1074000:AFK65_RS03605
uniprot id: A0A376E1K5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsQ/DivIB family. FtsQ subfamily.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

1074000:AFK65 RS08580
gene id: 1074000:AFK65_RS08580
uniprot id: A0A376ECN4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane.
messages: Belongs to the Lpp family.
messages: Cell outer membrane
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: cell wall

1074000:AFK65 RS03175
gene id: 1074000:AFK65_RS03175
uniprot id: A0A376E2D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TrpR family.
messages: Cytoplasm
messages: Homodimer.
messages: This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region.

1074000:AFK65 RS02235
gene id: 1074000:AFK65_RS02235
uniprot id: A0A376E0I5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiV subfamily.
messages: Forms an heterodimer with UbiU.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiU, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

1074000:AFK65 RS04865
gene id: 1074000:AFK65_RS04865
uniprot id: A0A376E3W3
names: Function
names: Similarity
messages: Belongs to the AcpH family.
messages: Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.

1074000:AFK65 RS15985
gene id: 1074000:AFK65_RS15985
uniprot id: A0A376EVV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LysR transcriptional regulatory family.
messages: Controls the transcription of genes involved in arginine and lysine metabolism.
messages: Homodimer.

1074000:AFK65 RS02530
gene id: 1074000:AFK65_RS02530
uniprot id: A0A376E1V2
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS12140
gene id: 1074000:AFK65_RS12140
uniprot id: A0A376EKC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

1074000:AFK65 RS06085
gene id: 1074000:AFK65_RS06085
uniprot id: A0A376E5Y2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.

1074000:AFK65 RS06450
gene id: 1074000:AFK65_RS06450
uniprot id: A0A376E742
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

1074000:AFK65 RS13875
gene id: 1074000:AFK65_RS13875
uniprot id: A0A376EP02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS10465
gene id: 1074000:AFK65_RS10465
uniprot id: A0A376EG23
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

1074000:AFK65 RS07890
gene id: 1074000:AFK65_RS07890
uniprot id: A0A376EAT7
names: Subcellular Location Annotation
messages: Cell inner membrane

1074000:AFK65 RS16860
gene id: 1074000:AFK65_RS16860
uniprot id: A0A376EWF1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cytochrome b562 family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per molecule.
messages: Electron-transport protein of unknown function.

1074000:AFK65 RS14900
gene id: 1074000:AFK65_RS14900
uniprot id: A0A376ERN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS17605
gene id: 1074000:AFK65_RS17605
uniprot id: A0A376EZX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the porin LamB (TC 1.B.3) family.
messages: Membrane

1074000:AFK65 RS17310
gene id: 1074000:AFK65_RS17310
uniprot id: A0A376EZH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1074000:AFK65 RS21235
gene id: 1074000:AFK65_RS21235
uniprot id: A0A376ERQ3
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

1074000:AFK65 RS03330
gene id: 1074000:AFK65_RS03330
uniprot id: A0A376E2G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1074000:AFK65 RS07790
gene id: 1074000:AFK65_RS07790
uniprot id: A0A376EBY4
names: Function
names: Similarity
messages: Belongs to the thiamine kinase family.
messages: Catalyzes the phosphorylation of thiamine to thiamine phosphate.

1074000:AFK65 RS01850
gene id: 1074000:AFK65_RS01850
uniprot id: A0A376DYI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Cell inner membrane
messages: Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.
messages: Membrane

1074000:AFK65 RS05735
gene id: 1074000:AFK65_RS05735
uniprot id: A0A376E6F0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1074000:AFK65 RS12870
gene id: 1074000:AFK65_RS12870
uniprot id: A0A376EPL8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Hydrolyzes GDP-mannose.

1074000:AFK65 RS06920
gene id: 1074000:AFK65_RS06920
uniprot id: A0A376E7H8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1074000:AFK65 RS08375
gene id: 1074000:AFK65_RS08375
uniprot id: A0A376EAP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS03420
gene id: 1074000:AFK65_RS03420
uniprot id: A0A376E2P0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

1074000:AFK65 RS16970
gene id: 1074000:AFK65_RS16970
uniprot id: A0A376EXV6
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS14675
gene id: 1074000:AFK65_RS14675
uniprot id: A0A376ETT5
names: Cofactor
names: Function
messages: Binds 1 [2Fe-2S] cluster.
messages: Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins.

1074000:AFK65 RS08995
gene id: 1074000:AFK65_RS08995
uniprot id: A0A376EE48
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

1074000:AFK65 RS10920
gene id: 1074000:AFK65_RS10920
uniprot id: A0A376EIZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS04350
gene id: 1074000:AFK65_RS04350
uniprot id: A0A376E456
names: Function
names: Similarity
messages: Belongs to the PqqC family.
messages: Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.

1074000:AFK65 RS11850
gene id: 1074000:AFK65_RS11850
uniprot id: A0A376EJS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CopD family.
messages: Cell inner membrane
messages: Involved in copper resistance.
messages: Membrane

1074000:AFK65 RS06805
gene id: 1074000:AFK65_RS06805
uniprot id: A0A376E744
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

1074000:AFK65 RS18365
gene id: 1074000:AFK65_RS18365
uniprot id: A0A376F068
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS13790
gene id: 1074000:AFK65_RS13790
uniprot id: A0A376ER99
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS18395
gene id: 1074000:AFK65_RS18395
uniprot id: A0A376EY03
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

1074000:AFK65 RS03940
gene id: 1074000:AFK65_RS03940
uniprot id: A0A376E477
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1074000:AFK65 RS13240
gene id: 1074000:AFK65_RS13240
uniprot id: A0A376EPW6
names: Function
names: Similarity
messages: Belongs to the esterase D family.
messages: Serine hydrolase involved in the detoxification of formaldehyde.

1074000:AFK65 RS06125
gene id: 1074000:AFK65_RS06125
uniprot id: A0A376E5F8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1074000:AFK65 RS00955
gene id: 1074000:AFK65_RS00955
uniprot id: A0A376DXA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 56 family.
messages: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.
messages: Cell inner membrane

1074000:AFK65 RS18055
gene id: 1074000:AFK65_RS18055
uniprot id: A0A376EY50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefB subfamily.
messages: Cell inner membrane
messages: Interacts with the regulatory subunit KefG.
messages: Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport.

1074000:AFK65 RS16550
gene id: 1074000:AFK65_RS16550
uniprot id: A0A376EVF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
messages: Monomer.

1074000:AFK65 RS14160
gene id: 1074000:AFK65_RS14160
uniprot id: A0A376ERK8
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1074000:AFK65 RS05045
gene id: 1074000:AFK65_RS05045
uniprot id: A0A376E440
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

1074000:AFK65 RS17570
gene id: 1074000:AFK65_RS17570
uniprot id: A0A376EXL8
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS04490
gene id: 1074000:AFK65_RS04490
uniprot id: A0A376E4F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS04915
gene id: 1074000:AFK65_RS04915
uniprot id: A0A376E3J2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

1074000:AFK65 RS09805
gene id: 1074000:AFK65_RS09805
uniprot id: A0A376EFT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

1074000:AFK65 RS05160
gene id: 1074000:AFK65_RS05160
uniprot id: A0A376E5I3
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1074000:AFK65 RS07260
gene id: 1074000:AFK65_RS07260
uniprot id: A0A376E837
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

1074000:AFK65 RS13745
gene id: 1074000:AFK65_RS13745
uniprot id: A0A376ERL4
names: Similarity
messages: Belongs to the GST superfamily.

1074000:AFK65 RS15350
gene id: 1074000:AFK65_RS15350
uniprot id: A0A376ETV3
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS14595
gene id: 1074000:AFK65_RS14595
uniprot id: A0A376ESH5
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
messages: Protects the bacterial cell from host peptidases.

1074000:AFK65 RS00680
gene id: 1074000:AFK65_RS00680
uniprot id: A0A376DWP0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MetJ family.
messages: Cytoplasm
messages: Does not bind DNA by a helix-turn-helix motif.
messages: Homodimer.
messages: This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.

1074000:AFK65 RS02335
gene id: 1074000:AFK65_RS02335
uniprot id: A0A376E0B3
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

1074000:AFK65 RS15485
gene id: 1074000:AFK65_RS15485
uniprot id: A0A376EUJ8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1074000:AFK65 RS18575
gene id: 1074000:AFK65_RS18575
uniprot id: A0A376F0Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

1074000:AFK65 RS09285
gene id: 1074000:AFK65_RS09285
uniprot id: A0A376EFT9
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: 4-aminobutanal can spontaneously cyclize to 1-pyrroline, and 5-aminopentanal to 1-piperideine.
messages: Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.
messages: Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
messages: Homotetramer.

1074000:AFK65 RS00960
gene id: 1074000:AFK65_RS00960
uniprot id: A0A376DXC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WzyE family.
messages: Cell inner membrane
messages: Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units.
messages: Probably part of a complex composed of WzxE, WzyE and WzzE.

1074000:AFK65 RS04775
gene id: 1074000:AFK65_RS04775
uniprot id: A0A376E3Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS16900
gene id: 1074000:AFK65_RS16900
uniprot id: A0A376EWL6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS03650
gene id: 1074000:AFK65_RS03650
uniprot id: A0A376E2Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1074000:AFK65 RS07635
gene id: 1074000:AFK65_RS07635
uniprot id: A0A376E8U0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

1074000:AFK65 RS04950
gene id: 1074000:AFK65_RS04950
uniprot id: A0A376E4Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1074000:AFK65 RS06095
gene id: 1074000:AFK65_RS06095
uniprot id: A0A376E5E1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.
messages: The heme is bound between the two transmembrane subunits.

1074000:AFK65 RS09135
gene id: 1074000:AFK65_RS09135
uniprot id: A0A376EE20
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS13010
gene id: 1074000:AFK65_RS13010
uniprot id: A0A376EPC5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.
messages: Binds 1 Mg(2+) ion per subunit. Ca(2+) may be able to substitute.
messages: Cytoplasm
messages: Probably phosphorylates lipids; the in vivo substrate is unknown.

1074000:AFK65 RS18595
gene id: 1074000:AFK65_RS18595
uniprot id: A0A376F076
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

1074000:AFK65 RS17115
gene id: 1074000:AFK65_RS17115
uniprot id: A0A376EZM5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1074000:AFK65 RS11085
gene id: 1074000:AFK65_RS11085
uniprot id: A0A376EJ34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1074000:AFK65 RS09680
gene id: 1074000:AFK65_RS09680
uniprot id: A0A376EFE3
names: Cofactor
messages: Binds 3 heme c groups covalently per subunit.

1074000:AFK65 RS17135
gene id: 1074000:AFK65_RS17135
uniprot id: A0A376EYG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.

1074000:AFK65 RS07705
gene id: 1074000:AFK65_RS07705
uniprot id: A0A376EAV9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1074000:AFK65 RS20270
gene id: 1074000:AFK65_RS20270
uniprot id: A0A376KQ47
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1074000:AFK65 RS04090
gene id: 1074000:AFK65_RS04090
uniprot id: A0A376E282
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS17745
gene id: 1074000:AFK65_RS17745
uniprot id: A0A376EZI8
names: Similarity
messages: Belongs to the malate synthase family.

1074000:AFK65 RS01755
gene id: 1074000:AFK65_RS01755
uniprot id: A0A376DYE4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1074000:AFK65 RS14855
gene id: 1074000:AFK65_RS14855
uniprot id: A0A376ERJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. SrmB subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity.
messages: Interacts with the 50S ribosomal subunit.

1074000:AFK65 RS09040
gene id: 1074000:AFK65_RS09040
uniprot id: A0A376EDT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1074000:AFK65 RS18350
gene id: 1074000:AFK65_RS18350
uniprot id: A0A376EZW4
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

1074000:AFK65 RS02155
gene id: 1074000:AFK65_RS02155
uniprot id: A0A376DZ86
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

1074000:AFK65 RS06935
gene id: 1074000:AFK65_RS06935
uniprot id: A0A376E898
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolA family.
messages: Monomer.
messages: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
messages: Periplasm

1074000:AFK65 RS20650
gene id: 1074000:AFK65_RS20650
uniprot id: A0A376E0L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0391 family.
messages: Cell membrane

1074000:AFK65 RS06135
gene id: 1074000:AFK65_RS06135
uniprot id: A0A376E5F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS13820
gene id: 1074000:AFK65_RS13820
uniprot id: A0A376ENU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS19275
gene id: 1074000:AFK65_RS19275
uniprot id: A0A376EZG3
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS04245
gene id: 1074000:AFK65_RS04245
uniprot id: A0A376E2D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Crl family.
messages: Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32.
messages: Cytoplasm

1074000:AFK65 RS11175
gene id: 1074000:AFK65_RS11175
uniprot id: A0A376EJ84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS00780
gene id: 1074000:AFK65_RS00780
uniprot id: A0A376DWX9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
messages: Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).

1074000:AFK65 RS17875
gene id: 1074000:AFK65_RS17875
uniprot id: A0A376EY33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1074000:AFK65 RS15320
gene id: 1074000:AFK65_RS15320
uniprot id: A0A376ES99
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1074000:AFK65 RS05630
gene id: 1074000:AFK65_RS05630
uniprot id: A0A376E660
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).

1074000:AFK65 RS12075
gene id: 1074000:AFK65_RS12075
uniprot id: A0A376EM80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CheZ family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).

1074000:AFK65 RS07605
gene id: 1074000:AFK65_RS07605
uniprot id: A0A376EAA1
names: Function
names: Similarity
messages: Belongs to the FlgM family.
messages: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

1074000:AFK65 RS19715
gene id: 1074000:AFK65_RS19715
uniprot id: A0A376F1B3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

1074000:AFK65 RS16475
gene id: 1074000:AFK65_RS16475
uniprot id: A0A376EY13
names: Similarity
messages: Belongs to the UDP-glycosyltransferase family.

1074000:AFK65 RS14550
gene id: 1074000:AFK65_RS14550
uniprot id: A0A376ESW6
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1074000:AFK65 RS19185
gene id: 1074000:AFK65_RS19185
uniprot id: A0A376F144
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

1074000:AFK65 RS09220
gene id: 1074000:AFK65_RS09220
uniprot id: A0A376EEP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS17910
gene id: 1074000:AFK65_RS17910
uniprot id: A0A376F0V4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1074000:AFK65 RS18405
gene id: 1074000:AFK65_RS18405
uniprot id: A0A376EYJ1
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin.

1074000:AFK65 RS16980
gene id: 1074000:AFK65_RS16980
uniprot id: A0A376EZE8
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1074000:AFK65 RS16285
gene id: 1074000:AFK65_RS16285
uniprot id: A0A376EVF1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS06530
gene id: 1074000:AFK65_RS06530
uniprot id: A0A376E8B4
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS16025
gene id: 1074000:AFK65_RS16025
uniprot id: A0A376EVQ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

1074000:AFK65 RS19400
gene id: 1074000:AFK65_RS19400
uniprot id: A0A376EZL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1074000:AFK65 RS05720
gene id: 1074000:AFK65_RS05720
uniprot id: A0A376E5W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuC/DcuD transporter (TC 2.A.61) family.
messages: Membrane

1074000:AFK65 RS03920
gene id: 1074000:AFK65_RS03920
uniprot id: A0A376E467
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

1074000:AFK65 RS17525
gene id: 1074000:AFK65_RS17525
uniprot id: A0A376EZ76
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1074000:AFK65 RS18735
gene id: 1074000:AFK65_RS18735
uniprot id: A0A376EY66
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS02230
gene id: 1074000:AFK65_RS02230
uniprot id: A0A376DZB6
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1074000:AFK65 RS01855
gene id: 1074000:AFK65_RS01855
uniprot id: A0A376DZG9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1074000:AFK65 RS19430
gene id: 1074000:AFK65_RS19430
uniprot id: A0A376F2N6
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1074000:AFK65 RS19760
gene id: 1074000:AFK65_RS19760
uniprot id: A0A376EZG6
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS11960
gene id: 1074000:AFK65_RS11960
uniprot id: A0A376EMM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1074000:AFK65 RS10800
gene id: 1074000:AFK65_RS10800
uniprot id: A0A376EIP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap.

1074000:AFK65 RS01560
gene id: 1074000:AFK65_RS01560
uniprot id: A0A0K2MYQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1074000:AFK65 RS15335
gene id: 1074000:AFK65_RS15335
uniprot id: A0A376EST4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UbiX/PAD1 family. YclB subfamily.
messages: Homododecamer.
messages: Involved in the non-oxidative decarboxylation and detoxification of phenolic derivatives. Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for phenolic acid decarboxylase.

1074000:AFK65 RS02960
gene id: 1074000:AFK65_RS02960
uniprot id: A0A376E233
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Cell inner membrane
messages: Involved in succinate export with YjjP. Both proteins are required for export.
messages: Membrane
messages: The transporter is composed of YjjB and YjjP.

1074000:AFK65 RS03565
gene id: 1074000:AFK65_RS03565
uniprot id: A0A376E3H3
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS02415
gene id: 1074000:AFK65_RS02415
uniprot id: A0A376DZI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS19565
gene id: 1074000:AFK65_RS19565
uniprot id: A0A376F2T6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the N-acylglucosamine 2-epimerase family.
messages: Catalyzes the isomerization of sulfoquinovose (SQ) to 6-deoxy-6-sulfo-D-fructose (SF).
messages: Homohexamer.

1074000:AFK65 RS01995
gene id: 1074000:AFK65_RS01995
uniprot id: A0A376DYV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 51 family.
messages: Cell inner membrane
messages: Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.

1074000:AFK65 RS01920
gene id: 1074000:AFK65_RS01920
uniprot id: A0A376E029
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.
messages: Homodimer.

1074000:AFK65 RS10055
gene id: 1074000:AFK65_RS10055
uniprot id: A0A376EF17
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS01570
gene id: 1074000:AFK65_RS01570
uniprot id: A0A376DY57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NusG family.
messages: Monomer. Interacts with the transcription termination factor Rho and with RNA polymerase.
messages: Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination.

1074000:AFK65 RS18770
gene id: 1074000:AFK65_RS18770
uniprot id: A0A376EYG4
names: Similarity
messages: Belongs to the peptidase M16 family.

1074000:AFK65 RS09845
gene id: 1074000:AFK65_RS09845
uniprot id: A0A376EF58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1074000:AFK65 RS17265
gene id: 1074000:AFK65_RS17265
uniprot id: A0A376EZD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FrdD family.
messages: Cell membrane
messages: Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).
messages: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth. Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.

1074000:AFK65 RS14690
gene id: 1074000:AFK65_RS14690
uniprot id: A0A376ERK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family. RcnA subfamily.
messages: Cell membrane
messages: Efflux system for nickel and cobalt.
messages: Membrane

1074000:AFK65 RS00900
gene id: 1074000:AFK65_RS00900
uniprot id: A0A376DYL8
names: Similarity
messages: Belongs to the thioredoxin family.

1074000:AFK65 RS02385
gene id: 1074000:AFK65_RS02385
uniprot id: A0A376E142
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

1074000:AFK65 RS05415
gene id: 1074000:AFK65_RS05415
uniprot id: A0A376E4V8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

1074000:AFK65 RS01790
gene id: 1074000:AFK65_RS01790
uniprot id: A0A376DZD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

1074000:AFK65 RS03830
gene id: 1074000:AFK65_RS03830
uniprot id: A0A376E255
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.

1074000:AFK65 RS01740
gene id: 1074000:AFK65_RS01740
uniprot id: A0A376E0H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS07290
gene id: 1074000:AFK65_RS07290
uniprot id: A0A376E8L8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS15885
gene id: 1074000:AFK65_RS15885
uniprot id: A0A376EUE1
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

1074000:AFK65 RS14240
gene id: 1074000:AFK65_RS14240
uniprot id: A0A376ERQ2
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

1074000:AFK65 RS16370
gene id: 1074000:AFK65_RS16370
uniprot id: A0A376EUV3
names: Similarity
messages: Belongs to the phage portal family. PBSX subfamily.

1074000:AFK65 RS06045
gene id: 1074000:AFK65_RS06045
uniprot id: A0A376E7R5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Provides significant protection from radiation damage and may be involved in the degradation of radiation-damaged nucleotides.
messages: Toroid-shaped homohexamer. In the hexamer, 3 dimers assemble to form a ring-like structure surrounding a central hole.

1074000:AFK65 RS02030
gene id: 1074000:AFK65_RS02030
uniprot id: A0A376DYS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptA family.
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
messages: Periplasm

1074000:AFK65 RS12245
gene id: 1074000:AFK65_RS12245
uniprot id: A0A376EMA4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.
messages: Cell inner membrane
messages: Involved in transporting aromatic amino acids across the cytoplasmic membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1074000:AFK65 RS14720
gene id: 1074000:AFK65_RS14720
uniprot id: A0A376ESU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS03510
gene id: 1074000:AFK65_RS03510
uniprot id: A0A376E2P6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1074000:AFK65 RS18020
gene id: 1074000:AFK65_RS18020
uniprot id: A0A376EZH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DsrF/TusC family.
messages: Cytoplasm
messages: Heterohexamer, formed by a dimer of trimers. The hexameric TusBCD complex contains 2 copies each of TusB, TusC and TusD. The TusBCD complex interacts with TusE.
messages: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.

1074000:AFK65 RS16185
gene id: 1074000:AFK65_RS16185
uniprot id: A0A376EUH5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MdcC family.
messages: Covalently binds the prosthetic group of malonate decarboxylase.
messages: Cytoplasm
messages: Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism.

1074000:AFK65 RS16560
gene id: 1074000:AFK65_RS16560
uniprot id: A0A376EV72
names: Similarity
messages: Belongs to the CitG/MdcB family.

1074000:AFK65 RS08750
gene id: 1074000:AFK65_RS08750
uniprot id: A0A376ED69
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS05740
gene id: 1074000:AFK65_RS05740
uniprot id: A0A376E5C7
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

1074000:AFK65 RS03590
gene id: 1074000:AFK65_RS03590
uniprot id: A0A376E1A1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

1074000:AFK65 RS19040
gene id: 1074000:AFK65_RS19040
uniprot id: A0A376F0Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
messages: Membrane

1074000:AFK65 RS07060
gene id: 1074000:AFK65_RS07060
uniprot id: A0A376E846
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family.
messages: Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs.

1074000:AFK65 RS13895
gene id: 1074000:AFK65_RS13895
uniprot id: A0A376EP22
names: Similarity
messages: Belongs to the UPF0115 family.

1074000:AFK65 RS03990
gene id: 1074000:AFK65_RS03990
uniprot id: A0A376E3M7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

1074000:AFK65 RS09690
gene id: 1074000:AFK65_RS09690
uniprot id: A0A376EGS5
names: Function
messages: Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.

1074000:AFK65 RS00965
gene id: 1074000:AFK65_RS00965
uniprot id: A0A376DXE4
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 26 family.
messages: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.

1074000:AFK65 RS02470
gene id: 1074000:AFK65_RS02470
uniprot id: A0A376E0K1
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

1074000:AFK65 RS06645
gene id: 1074000:AFK65_RS06645
uniprot id: A0A376E6T0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS16480
gene id: 1074000:AFK65_RS16480
uniprot id: A0A376EV27
names: Similarity
messages: Belongs to the lycopene cyclase family.

1074000:AFK65 RS15250
gene id: 1074000:AFK65_RS15250
uniprot id: A0A376ETY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

1074000:AFK65 RS06355
gene id: 1074000:AFK65_RS06355
uniprot id: A0A376E7R6
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

1074000:AFK65 RS05275
gene id: 1074000:AFK65_RS05275
uniprot id: A0A376E417
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1074000:AFK65 RS13470
gene id: 1074000:AFK65_RS13470
uniprot id: A0A376EQC9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gram-negative porin family.
messages: Cell outer membrane
messages: Homotrimer.
messages: Membrane

1074000:AFK65 RS02465
gene id: 1074000:AFK65_RS02465
uniprot id: A0A376DZU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmG family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.

1074000:AFK65 RS05040
gene id: 1074000:AFK65_RS05040
uniprot id: A0A376E5A2
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1074000:AFK65 RS18255
gene id: 1074000:AFK65_RS18255
uniprot id: A0A376EXN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IgaA family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS18090
gene id: 1074000:AFK65_RS18090
uniprot id: A0A376EYA9
names: Similarity
messages: Belongs to the UPF0270 family.

1074000:AFK65 RS03640
gene id: 1074000:AFK65_RS03640
uniprot id: A0A376E1F3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA gyrase inhibitor YacG family.
messages: Binds 1 zinc ion.
messages: Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
messages: Interacts with GyrB.

1074000:AFK65 RS07785
gene id: 1074000:AFK65_RS07785
uniprot id: A0A376E962
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LpoB family.
messages: Cell outer membrane
messages: Interacts with PBP1b.
messages: Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b).

1074000:AFK65 RS11280
gene id: 1074000:AFK65_RS11280
uniprot id: A0A376EHP8
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS07795
gene id: 1074000:AFK65_RS07795
uniprot id: A0A376EB31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
messages: Cytoplasm
messages: Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.

1074000:AFK65 RS19220
gene id: 1074000:AFK65_RS19220
uniprot id: A0A376F1P0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1074000:AFK65 RS08910
gene id: 1074000:AFK65_RS08910
uniprot id: A0A376ECH3
names: Domain
names: Function
names: Subunit
messages: Consists of two structural and functional domains: an N-terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization.
messages: Homodimer.
messages: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.

1074000:AFK65 RS14850
gene id: 1074000:AFK65_RS14850
uniprot id: A0A376ER36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).

1074000:AFK65 RS11220
gene id: 1074000:AFK65_RS11220
uniprot id: A0A376EKG2
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1074000:AFK65 RS07375
gene id: 1074000:AFK65_RS07375
uniprot id: A0A376E9M9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane
messages: Part of a ferrous iron transporter composed of EfeU, EfeO and EfeB.
messages: Uptake of Fe(2+) ions across the membrane.

1074000:AFK65 RS01660
gene id: 1074000:AFK65_RS01660
uniprot id: A0A376DYD1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Divalent metal cations. Mg(2+) or Mn(2+).
messages: Homodimer.
messages: mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.

1074000:AFK65 RS06995
gene id: 1074000:AFK65_RS06995
uniprot id: A0A376E804
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1074000:AFK65 RS15065
gene id: 1074000:AFK65_RS15065
uniprot id: A0A376ET01
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

1074000:AFK65 RS18790
gene id: 1074000:AFK65_RS18790
uniprot id: A0A376F0P4
names: Similarity
messages: Belongs to the glycosyl hydrolase 8 (cellulase D) family.

1074000:AFK65 RS15930
gene id: 1074000:AFK65_RS15930
uniprot id: A0A376EVF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1074000:AFK65 RS12690
gene id: 1074000:AFK65_RS12690
uniprot id: A0A376EN89
names: Similarity
messages: Belongs to the UPF0265 family.

1074000:AFK65 RS20200
gene id: 1074000:AFK65_RS20200
uniprot id: A0A376KS36
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS13545
gene id: 1074000:AFK65_RS13545
uniprot id: A0A376EQK1
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

1074000:AFK65 RS15510
gene id: 1074000:AFK65_RS15510
uniprot id: A0A376ETF5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS06175
gene id: 1074000:AFK65_RS06175
uniprot id: A0A376E864
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Cell outer membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1074000:AFK65 RS13680
gene id: 1074000:AFK65_RS13680
uniprot id: A0A376ENT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 5DNU family.
messages: Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS03870
gene id: 1074000:AFK65_RS03870
uniprot id: A0A376E1X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1074000:AFK65 RS09710
gene id: 1074000:AFK65_RS09710
uniprot id: A0A376EFG1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1074000:AFK65 RS03935
gene id: 1074000:AFK65_RS03935
uniprot id: A0A376E222
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1074000:AFK65 RS13605
gene id: 1074000:AFK65_RS13605
uniprot id: A0A376ENB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1074000:AFK65 RS12925
gene id: 1074000:AFK65_RS12925
uniprot id: A0A376ELV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BexD/CtrA/VexA family.
messages: Cell outer membrane
messages: Membrane

1074000:AFK65 RS07910
gene id: 1074000:AFK65_RS07910
uniprot id: A0A376EA45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs.
messages: Cytoplasm
messages: Interacts with TusE.

1074000:AFK65 RS09115
gene id: 1074000:AFK65_RS09115
uniprot id: A0A376EFB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

1074000:AFK65 RS13710
gene id: 1074000:AFK65_RS13710
uniprot id: A0A376EQF1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homohexamer.
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

1074000:AFK65 RS14490
gene id: 1074000:AFK65_RS14490
uniprot id: A0A376EQG2
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

1074000:AFK65 RS06375
gene id: 1074000:AFK65_RS06375
uniprot id: A0A376E7I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

1074000:AFK65 RS03400
gene id: 1074000:AFK65_RS03400
uniprot id: A0A376E2N0
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

1074000:AFK65 RS16605
gene id: 1074000:AFK65_RS16605
uniprot id: A0A376EW17
names: Subcellular Location Annotation
messages: Cytoplasm

1074000:AFK65 RS13525
gene id: 1074000:AFK65_RS13525
uniprot id: A0A376ENV7
names: Similarity
messages: Belongs to the CinA family.

1074000:AFK65 RS13915
gene id: 1074000:AFK65_RS13915
uniprot id: A0A376EP29
names: Similarity
messages: Belongs to the UPF0381 family.

1074000:AFK65 RS12040
gene id: 1074000:AFK65_RS12040
uniprot id: A0A376EL49
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1074000:AFK65 RS10210
gene id: 1074000:AFK65_RS10210
uniprot id: A0A376EG47
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS10415
gene id: 1074000:AFK65_RS10415
uniprot id: A0A376EFS6
names: Function
names: Similarity
messages: Belongs to the TorD/DmsD family. DmsD subfamily.
messages: Required for biogenesis/assembly of DMSO reductase, but not for the interaction of the DmsA signal peptide with the Tat system. May be part of a chaperone cascade complex that facilitates a folding-maturation pathway for the substrate protein.

1074000:AFK65 RS19610
gene id: 1074000:AFK65_RS19610
uniprot id: A0A376F2V9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

1074000:AFK65 RS03490
gene id: 1074000:AFK65_RS03490
uniprot id: A0A376E2N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Periplasm

1074000:AFK65 RS15645
gene id: 1074000:AFK65_RS15645
uniprot id: A0A376EUJ0
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS15435
gene id: 1074000:AFK65_RS15435
uniprot id: A0A376ET31
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS11195
gene id: 1074000:AFK65_RS11195
uniprot id: A0A376EJD6
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

1074000:AFK65 RS20110
gene id: 1074000:AFK65_RS20110
uniprot id: A0A376KS20
names: Similarity
messages: Belongs to the ParB family.

1074000:AFK65 RS02400
gene id: 1074000:AFK65_RS02400
uniprot id: A0A376E1N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ElaB/YgaM/YqjD family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS08965
gene id: 1074000:AFK65_RS08965
uniprot id: A0A376EC14
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1074000:AFK65 RS06140
gene id: 1074000:AFK65_RS06140
uniprot id: A0A376E623
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

1074000:AFK65 RS08875
gene id: 1074000:AFK65_RS08875
uniprot id: A0A376EDV3
names: Function
messages: Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.

1074000:AFK65 RS19580
gene id: 1074000:AFK65_RS19580
uniprot id: A0A376F230
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
messages: Membrane

1074000:AFK65 RS03560
gene id: 1074000:AFK65_RS03560
uniprot id: A0A376E199
names: Function
names: Similarity
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.

1074000:AFK65 RS07595
gene id: 1074000:AFK65_RS07595
uniprot id: A0A376EA62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

1074000:AFK65 RS02120
gene id: 1074000:AFK65_RS02120
uniprot id: A0A376E0D2
names: Subcellular Location Annotation
messages: Cell inner membrane

1074000:AFK65 RS08900
gene id: 1074000:AFK65_RS08900
uniprot id: A0A376EDX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS19735
gene id: 1074000:AFK65_RS19735
uniprot id: A0A376EZF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
messages: Cytoplasm

1074000:AFK65 RS19840
gene id: 1074000:AFK65_RS19840
uniprot id: A0A376F1L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS15010
gene id: 1074000:AFK65_RS15010
uniprot id: A0A376EUE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1074000:AFK65 RS06385
gene id: 1074000:AFK65_RS06385
uniprot id: A0A376E7V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsB sub-subfamily.
messages: Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell membrane

1074000:AFK65 RS08080
gene id: 1074000:AFK65_RS08080
uniprot id: A0A376ECL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

1074000:AFK65 RS08140
gene id: 1074000:AFK65_RS08140
uniprot id: A0A376EBB9
names: Caution
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS04835
gene id: 1074000:AFK65_RS04835
uniprot id: A0A376E500
names: Function
messages: Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals.

1074000:AFK65 RS05035
gene id: 1074000:AFK65_RS05035
uniprot id: A0A376E3Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1074000:AFK65 RS03850
gene id: 1074000:AFK65_RS03850
uniprot id: A0A376E260
names: Function
names: Similarity
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

1074000:AFK65 RS16135
gene id: 1074000:AFK65_RS16135
uniprot id: A0A376EV00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

1074000:AFK65 RS10400
gene id: 1074000:AFK65_RS10400
uniprot id: A0A376EHI2
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1074000:AFK65 RS05335
gene id: 1074000:AFK65_RS05335
uniprot id: A0A376E4M1
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1074000:AFK65 RS04905
gene id: 1074000:AFK65_RS04905
uniprot id: A0A376E3X1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1074000:AFK65 RS16920
gene id: 1074000:AFK65_RS16920
uniprot id: A0A376EXS3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1074000:AFK65 RS18535
gene id: 1074000:AFK65_RS18535
uniprot id: A0A376F0E0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PanZ/PanM family.
messages: Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion.
messages: Interacts with PanD in the presence of CoA.

1074000:AFK65 RS08870
gene id: 1074000:AFK65_RS08870
uniprot id: A0A376EES1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.

1074000:AFK65 RS02765
gene id: 1074000:AFK65_RS02765
uniprot id: A0A376E062
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1074000:AFK65 RS00835
gene id: 1074000:AFK65_RS00835
uniprot id: A0A376DYI5
names: Similarity
messages: Belongs to the UPF0438 family.

1074000:AFK65 RS09795
gene id: 1074000:AFK65_RS09795
uniprot id: A0A376EFQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS08520
gene id: 1074000:AFK65_RS08520
uniprot id: A0A376ECN3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thioesterase PaaI family.
messages: Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA).
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS09240
gene id: 1074000:AFK65_RS09240
uniprot id: A0A376EFP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
messages: Membrane

1074000:AFK65 RS08895
gene id: 1074000:AFK65_RS08895
uniprot id: A0A376EEU4
names: Similarity
messages: Belongs to the CFA/CMAS family.

1074000:AFK65 RS05995
gene id: 1074000:AFK65_RS05995
uniprot id: A0A376E7M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
messages: Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS03950
gene id: 1074000:AFK65_RS03950
uniprot id: A0A376E218
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1074000:AFK65 RS14830
gene id: 1074000:AFK65_RS14830
uniprot id: A0A376ERT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RseB family.
messages: Periplasm

1074000:AFK65 RS01875
gene id: 1074000:AFK65_RS01875
uniprot id: A0A376E010
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS16990
gene id: 1074000:AFK65_RS16990
uniprot id: A0A376EYX6
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS03205
gene id: 1074000:AFK65_RS03205
uniprot id: A0A376E0V9
names: Subcellular Location Annotation
messages: Cell inner membrane

1074000:AFK65 RS12365
gene id: 1074000:AFK65_RS12365
uniprot id: A0A376ENJ0
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1074000:AFK65 RS06290
gene id: 1074000:AFK65_RS06290
uniprot id: A0A376E772
names: Function
names: Similarity
messages: Belongs to the cycloisomerase 2 family.
messages: Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

1074000:AFK65 RS02160
gene id: 1074000:AFK65_RS02160
uniprot id: A0A376E0F3
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1074000:AFK65 RS04805
gene id: 1074000:AFK65_RS04805
uniprot id: A0A376E4G4
names: Function
names: Similarity
messages: Belongs to the nucleoside phosphorylase PpnP family.
messages: Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.

1074000:AFK65 RS03335
gene id: 1074000:AFK65_RS03335
uniprot id: A0A376E123
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1074000:AFK65 RS00875
gene id: 1074000:AFK65_RS00875
uniprot id: A0A376DX43
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS01325
gene id: 1074000:AFK65_RS01325
uniprot id: A0A376DY53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

1074000:AFK65 RS13340
gene id: 1074000:AFK65_RS13340
uniprot id: A0A376EQL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS05845
gene id: 1074000:AFK65_RS05845
uniprot id: A0A376E5G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS05910
gene id: 1074000:AFK65_RS05910
uniprot id: A0A376E4Z3
names: Similarity
messages: Belongs to the asparagine synthetase family.

1074000:AFK65 RS12445
gene id: 1074000:AFK65_RS12445
uniprot id: A0A376ELZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

1074000:AFK65 RS16190
gene id: 1074000:AFK65_RS16190
uniprot id: A0A376EWA3
names: Function
names: Similarity
messages: Belongs to the CitG/MdcB family.
messages: Involved in the formation of 2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase.

1074000:AFK65 RS07185
gene id: 1074000:AFK65_RS07185
uniprot id: A0A376E8U6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

1074000:AFK65 RS14075
gene id: 1074000:AFK65_RS14075
uniprot id: A0A376EQA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Cell membrane
messages: H(+)-stimulated, divalent metal cation uptake system.

1074000:AFK65 RS05705
gene id: 1074000:AFK65_RS05705
uniprot id: A0A376E518
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1074000:AFK65 RS20295
gene id: 1074000:AFK65_RS20295
uniprot id: A0A376KQ58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1074000:AFK65 RS17560
gene id: 1074000:AFK65_RS17560
uniprot id: A0A376EX38
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

1074000:AFK65 RS11535
gene id: 1074000:AFK65_RS11535
uniprot id: A0A376EKY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility.
messages: Bacterial flagellum basal body
messages: Belongs to the YcgR family.
messages: Monomer. Interacts with the flagellar basal bodies.

1074000:AFK65 RS19850
gene id: 1074000:AFK65_RS19850
uniprot id: A0A376F026
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. PhoU is essential for the repression of the Pho regulon at high phosphate conditions.

1074000:AFK65 RS18025
gene id: 1074000:AFK65_RS18025
uniprot id: A0A376F0C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DsrE/TusD family.
messages: Cytoplasm
messages: Heterohexamer, formed by a dimer of trimers. The hexameric TusBCD complex contains 2 copies each of TusB, TusC and TusD. The TusBCD complex interacts with TusE.
messages: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE.

1074000:AFK65 RS12800
gene id: 1074000:AFK65_RS12800
uniprot id: K8DCF5
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

1074000:AFK65 RS16245
gene id: 1074000:AFK65_RS16245
uniprot id: A0A376EXK0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates zinc uptake. May also transport other divalent cations.
messages: Membrane

1074000:AFK65 RS10275
gene id: 1074000:AFK65_RS10275
uniprot id: A0A376EFL1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS14960
gene id: 1074000:AFK65_RS14960
uniprot id: A0A376ETA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamD family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery.

1074000:AFK65 RS17230
gene id: 1074000:AFK65_RS17230
uniprot id: A0A376EX06
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1074000:AFK65 RS07110
gene id: 1074000:AFK65_RS07110
uniprot id: A0A376E7V0
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1074000:AFK65 RS11740
gene id: 1074000:AFK65_RS11740
uniprot id: A0A376EKC6
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS17050
gene id: 1074000:AFK65_RS17050
uniprot id: A0A376EYC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RIC family. YtfE subfamily.
messages: Cytoplasm
messages: Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
messages: Homodimer.

1074000:AFK65 RS19570
gene id: 1074000:AFK65_RS19570
uniprot id: A0A376F002
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

1074000:AFK65 RS13905
gene id: 1074000:AFK65_RS13905
uniprot id: A0A376EQY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
messages: Cytoplasm
messages: Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

1074000:AFK65 RS15075
gene id: 1074000:AFK65_RS15075
uniprot id: A0A376ET07
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1074000:AFK65 RS07455
gene id: 1074000:AFK65_RS07455
uniprot id: A0A376E9U4
names: Function
messages: May be involved in the biogenesis of curli organelles.

1074000:AFK65 RS10870
gene id: 1074000:AFK65_RS10870
uniprot id: A0A376EIU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS14680
gene id: 1074000:AFK65_RS14680
uniprot id: A0A376ETJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS12095
gene id: 1074000:AFK65_RS12095
uniprot id: A0A376EK98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane

1074000:AFK65 RS14110
gene id: 1074000:AFK65_RS14110
uniprot id: A0A376ESJ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

1074000:AFK65 RS06500
gene id: 1074000:AFK65_RS06500
uniprot id: A0A376E930
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1074000:AFK65 RS06485
gene id: 1074000:AFK65_RS06485
uniprot id: A0A376E920
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1074000:AFK65 RS14485
gene id: 1074000:AFK65_RS14485
uniprot id: A0A376EQE2
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

1074000:AFK65 RS09390
gene id: 1074000:AFK65_RS09390
uniprot id: A0A376ED50
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.

1074000:AFK65 RS18555
gene id: 1074000:AFK65_RS18555
uniprot id: A0A376EYQ7
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1074000:AFK65 RS06540
gene id: 1074000:AFK65_RS06540
uniprot id: A0A376E704
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS07330
gene id: 1074000:AFK65_RS07330
uniprot id: A0A376E947
names: Function
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Hydrolase RutD family.
messages: Involved in pyrimidine catabolism. May facilitate the hydrolysis of carbamate, a reaction that can also occur spontaneously.

1074000:AFK65 RS00405
gene id: 1074000:AFK65_RS00405
uniprot id: A0A376DWC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1074000:AFK65 RS19130
gene id: 1074000:AFK65_RS19130
uniprot id: A0A376EYJ5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1074000:AFK65 RS14005
gene id: 1074000:AFK65_RS14005
uniprot id: A0A376EQ33
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1074000:AFK65 RS00580
gene id: 1074000:AFK65_RS00580
uniprot id: A0A376DXZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L-rhamnose transporter (TC 2.A.7.6) family.
messages: Cell membrane
messages: Uptake of L-rhamnose across the cytoplasmic membrane with the concomitant transport of protons into the cell (symport system).

1074000:AFK65 RS14725
gene id: 1074000:AFK65_RS14725
uniprot id: A0A376ESB6
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: Belongs to the globin family. Two-domain flavohemoproteins subfamily.
messages: Binds 1 FAD per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Consists of two distinct domains; an N-terminal heme-containing oxygen-binding domain and a C-terminal reductase domain with binding sites for FAD and NAD(P)H.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS14335
gene id: 1074000:AFK65_RS14335
uniprot id: A0A376EQE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1074000:AFK65 RS14835
gene id: 1074000:AFK65_RS14835
uniprot id: A0A376ET34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E.
messages: Belongs to the RseA family.
messages: Cell inner membrane
messages: Interacts 1:1 with ECF RNA polymerase sigma-E (RpoE); this inhibits the interaction of sigma-E with the RNA polymerase catalytic core and leads to a decreased expression of sigma-E-regulated genes. Interacts with RseB.

1074000:AFK65 RS12155
gene id: 1074000:AFK65_RS12155
uniprot id: A0A376ELE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm
messages: Required for resistance to DNA-damaging agents.

1074000:AFK65 RS00925
gene id: 1074000:AFK65_RS00925
uniprot id: A0A376DXI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily.
messages: Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).
messages: Homodimer.

1074000:AFK65 RS01355
gene id: 1074000:AFK65_RS01355
uniprot id: A0A376DY10
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

1074000:AFK65 RS13785
gene id: 1074000:AFK65_RS13785
uniprot id: A0A376EQM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Periplasm

1074000:AFK65 RS09185
gene id: 1074000:AFK65_RS09185
uniprot id: A0A376ECK8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

1074000:AFK65 RS13660
gene id: 1074000:AFK65_RS13660
uniprot id: A0A376EQA5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1074000:AFK65 RS00455
gene id: 1074000:AFK65_RS00455
uniprot id: A0A376DXW8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

1074000:AFK65 RS07620
gene id: 1074000:AFK65_RS07620
uniprot id: A0A376EBJ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

1074000:AFK65 RS07670
gene id: 1074000:AFK65_RS07670
uniprot id: A0A376EBM5
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS04325
gene id: 1074000:AFK65_RS04325
uniprot id: A0A376E413
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.

1074000:AFK65 RS04060
gene id: 1074000:AFK65_RS04060
uniprot id: A0A376E3Q9
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

1074000:AFK65 RS01680
gene id: 1074000:AFK65_RS01680
uniprot id: A0A376DYE1
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1074000:AFK65 RS02985
gene id: 1074000:AFK65_RS02985
uniprot id: A0A376E1Z2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

1074000:AFK65 RS09235
gene id: 1074000:AFK65_RS09235
uniprot id: A0A376EEC6
names: Similarity
messages: Belongs to the glycosyl hydrolase 51 family.

1074000:AFK65 RS04830
gene id: 1074000:AFK65_RS04830
uniprot id: A0A376E4Z5
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

1074000:AFK65 RS16865
gene id: 1074000:AFK65_RS16865
uniprot id: A0A376EY08
names: Function
names: Similarity
messages: Belongs to the peptidase U62 family.
messages: Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA).

1074000:AFK65 RS07435
gene id: 1074000:AFK65_RS07435
uniprot id: A0A376E8F3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the PHP family.
messages: Binds 3 Zn(2+) ions per subunit.
messages: Homotrimer.

1074000:AFK65 RS17980
gene id: 1074000:AFK65_RS17980
uniprot id: A0A376EY20
names: Similarity
messages: Belongs to the peptidase A24 family.

1074000:AFK65 RS16695
gene id: 1074000:AFK65_RS16695
uniprot id: A0A376EW98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0114 family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS06015
gene id: 1074000:AFK65_RS06015
uniprot id: A0A376E5S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1074000:AFK65 RS06555
gene id: 1074000:AFK65_RS06555
uniprot id: A0A376E6K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YkuD family.
messages: Periplasm

1074000:AFK65 RS06405
gene id: 1074000:AFK65_RS06405
uniprot id: A0A376E6A5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS09880
gene id: 1074000:AFK65_RS09880
uniprot id: A0A376EEH5
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS17005
gene id: 1074000:AFK65_RS17005
uniprot id: A0A376EYY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

1074000:AFK65 RS10220
gene id: 1074000:AFK65_RS10220
uniprot id: A0A376EFM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family.
messages: Cell membrane
messages: Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.
messages: Membrane

1074000:AFK65 RS16160
gene id: 1074000:AFK65_RS16160
uniprot id: A0A376EXC1
names: Similarity
messages: Belongs to the fabD family.

1074000:AFK65 RS05130
gene id: 1074000:AFK65_RS05130
uniprot id: A0A376E3Y7
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

1074000:AFK65 RS10540
gene id: 1074000:AFK65_RS10540
uniprot id: A0A376EG93
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

1074000:AFK65 RS02850
gene id: 1074000:AFK65_RS02850
uniprot id: A0A376E0H9
names: Similarity
messages: Belongs to the glycosyl hydrolase 42 family.

1074000:AFK65 RS11235
gene id: 1074000:AFK65_RS11235
uniprot id: A0A376EKH2
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

1074000:AFK65 RS10245
gene id: 1074000:AFK65_RS10245
uniprot id: A0A376EFJ2
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS10425
gene id: 1074000:AFK65_RS10425
uniprot id: A0A376EHK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS09885
gene id: 1074000:AFK65_RS09885
uniprot id: A0A376EF16
names: Function
names: Similarity
messages: Belongs to the class-C beta-lactamase family.
messages: This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

1074000:AFK65 RS04790
gene id: 1074000:AFK65_RS04790
uniprot id: A0A376E3B6
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family. AroL subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: The LID domain closes over the active site upon ATP binding.

1074000:AFK65 RS06755
gene id: 1074000:AFK65_RS06755
uniprot id: A0A376E720
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS17325
gene id: 1074000:AFK65_RS17325
uniprot id: A0A376EYV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane
messages: Responsible for the transport of C4-dicarboxylates.

1074000:AFK65 RS20365
gene id: 1074000:AFK65_RS20365
uniprot id: A0A376KU70
names: Similarity
messages: Belongs to the ArsC family.

1074000:AFK65 RS05025
gene id: 1074000:AFK65_RS05025
uniprot id: A0A376E617
names: Similarity
messages: Belongs to the BolA/IbaG family.

1074000:AFK65 RS18665
gene id: 1074000:AFK65_RS18665
uniprot id: A0A376F0J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily.
messages: Membrane

1074000:AFK65 RS10470
gene id: 1074000:AFK65_RS10470
uniprot id: A0A376EIS8
names: Similarity
messages: Belongs to the peptidase S1B family.

1074000:AFK65 RS02815
gene id: 1074000:AFK65_RS02815
uniprot id: A0A376E0K3
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1074000:AFK65 RS04190
gene id: 1074000:AFK65_RS04190
uniprot id: A0A376E2E3
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

1074000:AFK65 RS18605
gene id: 1074000:AFK65_RS18605
uniprot id: A0A376EYS4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1074000:AFK65 RS17680
gene id: 1074000:AFK65_RS17680
uniprot id: A0A376F005
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1074000:AFK65 RS12780
gene id: 1074000:AFK65_RS12780
uniprot id: A0A376ENR7
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS01050
gene id: 1074000:AFK65_RS01050
uniprot id: A0A376DXQ7
names: Similarity
messages: Belongs to the GSP E family.

1074000:AFK65 RS09170
gene id: 1074000:AFK65_RS09170
uniprot id: A0A376EEK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Heterodimer of an alpha and a beta chain.
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1074000:AFK65 RS16305
gene id: 1074000:AFK65_RS16305
uniprot id: A0A376EUW5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1074000:AFK65 RS04470
gene id: 1074000:AFK65_RS04470
uniprot id: A0A376E2R3
names: Similarity
messages: Belongs to the TPP enzyme family.

1074000:AFK65 RS17985
gene id: 1074000:AFK65_RS17985
uniprot id: A0A376F0Y8
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

1074000:AFK65 RS19830
gene id: 1074000:AFK65_RS19830
uniprot id: A0A376F337
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PstS family.
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

1074000:AFK65 RS07675
gene id: 1074000:AFK65_RS07675
uniprot id: A0A376EAB3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS19865
gene id: 1074000:AFK65_RS19865
uniprot id: A0A376F2F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS19290
gene id: 1074000:AFK65_RS19290
uniprot id: A0A376F0W2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

1074000:AFK65 RS07165
gene id: 1074000:AFK65_RS07165
uniprot id: A0A376E8C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

1074000:AFK65 RS13825
gene id: 1074000:AFK65_RS13825
uniprot id: A0A376EQ55
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS08150
gene id: 1074000:AFK65_RS08150
uniprot id: A0A376EBC1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0756 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS13070
gene id: 1074000:AFK65_RS13070
uniprot id: A0A376EM39
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS15765
gene id: 1074000:AFK65_RS15765
uniprot id: A0A376EUW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS04010
gene id: 1074000:AFK65_RS04010
uniprot id: A0A376E4A6
names: Subcellular Location Annotation
messages: Cytoplasm

1074000:AFK65 RS20340
gene id: 1074000:AFK65_RS20340
uniprot id: A0A376KR77
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1074000:AFK65 RS16060
gene id: 1074000:AFK65_RS16060
uniprot id: A0A376EXF8
names: Similarity
messages: Belongs to the EndA/NucM nuclease family.

1074000:AFK65 RS07530
gene id: 1074000:AFK65_RS07530
uniprot id: A0A376EA03
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

1074000:AFK65 RS00605
gene id: 1074000:AFK65_RS00605
uniprot id: A0A376DY03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell inner membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

1074000:AFK65 RS01695
gene id: 1074000:AFK65_RS01695
uniprot id: A0A376DYM4
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1074000:AFK65 RS01690
gene id: 1074000:AFK65_RS01690
uniprot id: A0A376DZY9
names: Similarity
messages: Belongs to the GARS family.

1074000:AFK65 RS13445
gene id: 1074000:AFK65_RS13445
uniprot id: A0A376ENP1
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS17615
gene id: 1074000:AFK65_RS17615
uniprot id: A0A376EZD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins.
messages: Periplasm

1074000:AFK65 RS03985
gene id: 1074000:AFK65_RS03985
uniprot id: A0A376E2C5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-(hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

1074000:AFK65 RS16595
gene id: 1074000:AFK65_RS16595
uniprot id: A0A376EYS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:citrate (SCF) symporter family.
messages: Cell membrane
messages: Uptake of citrate across the boundary membrane with the concomitant uptake of a sodium ion (symport system).

1074000:AFK65 RS05860
gene id: 1074000:AFK65_RS05860
uniprot id: A0A376E523
names: Similarity
messages: Belongs to the PhoH family.

1074000:AFK65 RS07830
gene id: 1074000:AFK65_RS07830
uniprot id: A0A376E992
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1074000:AFK65 RS10710
gene id: 1074000:AFK65_RS10710
uniprot id: A0A376EH22
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1074000:AFK65 RS03405
gene id: 1074000:AFK65_RS03405
uniprot id: A0A376E2J8
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

1074000:AFK65 RS17590
gene id: 1074000:AFK65_RS17590
uniprot id: A0A376F0J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
messages: Cell inner membrane

1074000:AFK65 RS19355
gene id: 1074000:AFK65_RS19355
uniprot id: A0A376F2K5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1074000:AFK65 RS16275
gene id: 1074000:AFK65_RS16275
uniprot id: A0A376EUN8
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS03090
gene id: 1074000:AFK65_RS03090
uniprot id: A0A376E0L5
names: Similarity
messages: Belongs to the Smp family.

1074000:AFK65 RS08435
gene id: 1074000:AFK65_RS08435
uniprot id: A0A376EDR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

1074000:AFK65 RS16290
gene id: 1074000:AFK65_RS16290
uniprot id: A0A376EWY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
messages: Homooctamer.

1074000:AFK65 RS06515
gene id: 1074000:AFK65_RS06515
uniprot id: A0A376E6Y6
names: Similarity
messages: Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpX family.

1074000:AFK65 RS12325
gene id: 1074000:AFK65_RS12325
uniprot id: A0A376EKT8
names: Function
names: Similarity
messages: Belongs to the LuxC family.
messages: LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.

1074000:AFK65 RS12165
gene id: 1074000:AFK65_RS12165
uniprot id: A0A376EM55
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

1074000:AFK65 RS15415
gene id: 1074000:AFK65_RS15415
uniprot id: A0A376EUT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

1074000:AFK65 RS07850
gene id: 1074000:AFK65_RS07850
uniprot id: A0A376EC38
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family. NagK subfamily.
messages: Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.

1074000:AFK65 RS11640
gene id: 1074000:AFK65_RS11640
uniprot id: A0A376EK93
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

1074000:AFK65 RS12990
gene id: 1074000:AFK65_RS12990
uniprot id: A0A376EPB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Cell membrane
messages: Membrane

1074000:AFK65 RS05985
gene id: 1074000:AFK65_RS05985
uniprot id: A0A376E6F2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SeqA family.
messages: Cytoplasm
messages: Homodimer. Polymerizes to form helical filaments.
messages: Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.

1074000:AFK65 RS18420
gene id: 1074000:AFK65_RS18420
uniprot id: A0A376F000
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1074000:AFK65 RS00950
gene id: 1074000:AFK65_RS00950
uniprot id: A0A376DZE7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA).
messages: Membrane
messages: Probably part of a complex composed of WzxE, WzyE and WzzE.

1074000:AFK65 RS05215
gene id: 1074000:AFK65_RS05215
uniprot id: A0A376E3Y5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1074000:AFK65 RS03505
gene id: 1074000:AFK65_RS03505
uniprot id: A0A376E1F9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1074000:AFK65 RS16675
gene id: 1074000:AFK65_RS16675
uniprot id: A0A376EXR0
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

1074000:AFK65 RS03570
gene id: 1074000:AFK65_RS03570
uniprot id: A0A376E1I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1074000:AFK65 RS03500
gene id: 1074000:AFK65_RS03500
uniprot id: A0A376E1F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Set transporter family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS20870
gene id: 1074000:AFK65_RS20870
uniprot id: A0A376EA09
names: Function
names: Similarity
messages: Belongs to the DUF177 domain family.
messages: Plays a role in synthesis, processing and/or stability of 23S rRNA.

1074000:AFK65 RS03320
gene id: 1074000:AFK65_RS03320
uniprot id: A0A376E149
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

1074000:AFK65 RS00760
gene id: 1074000:AFK65_RS00760
uniprot id: A0A376DZ18
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS06900
gene id: 1074000:AFK65_RS06900
uniprot id: A0A376E9Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1074000:AFK65 RS11430
gene id: 1074000:AFK65_RS11430
uniprot id: A0A376EJV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

1074000:AFK65 RS14950
gene id: 1074000:AFK65_RS14950
uniprot id: A0A376ER97
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

1074000:AFK65 RS07035
gene id: 1074000:AFK65_RS07035
uniprot id: A0A376E7L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

1074000:AFK65 RS14430
gene id: 1074000:AFK65_RS14430
uniprot id: A0A376ESM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamC family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

1074000:AFK65 RS08485
gene id: 1074000:AFK65_RS08485
uniprot id: A0A376ECD3
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

1074000:AFK65 RS14685
gene id: 1074000:AFK65_RS14685
uniprot id: A0A376ES86
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1074000:AFK65 RS11090
gene id: 1074000:AFK65_RS11090
uniprot id: A0A376EJ25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1074000:AFK65 RS16070
gene id: 1074000:AFK65_RS16070
uniprot id: A0A376EUS8
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

1074000:AFK65 RS12460
gene id: 1074000:AFK65_RS12460
uniprot id: A0A376EKW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Flagellar protein that affects chemotactic events.
messages: Membrane

1074000:AFK65 RS15155
gene id: 1074000:AFK65_RS15155
uniprot id: A0A376ETU8
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1074000:AFK65 RS17180
gene id: 1074000:AFK65_RS17180
uniprot id: A0A376EY93
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1074000:AFK65 RS10050
gene id: 1074000:AFK65_RS10050
uniprot id: A0A376EGJ8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS08800
gene id: 1074000:AFK65_RS08800
uniprot id: A0A376EBN5
names: Function
messages: Repressor involved in choline regulation of the bet genes.
messages: Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine.

1074000:AFK65 RS19165
gene id: 1074000:AFK65_RS19165
uniprot id: A0A376EYT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: Homotetramer.

1074000:AFK65 RS11925
gene id: 1074000:AFK65_RS11925
uniprot id: A0A376EKG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M23B family.
messages: Membrane

1074000:AFK65 RS09045
gene id: 1074000:AFK65_RS09045
uniprot id: A0A376EDU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1074000:AFK65 RS17060
gene id: 1074000:AFK65_RS17060
uniprot id: A0A376EYJ2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1074000:AFK65 RS05930
gene id: 1074000:AFK65_RS05930
uniprot id: A0A376E4Z8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS19215
gene id: 1074000:AFK65_RS19215
uniprot id: A0A376F0W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

1074000:AFK65 RS04195
gene id: 1074000:AFK65_RS04195
uniprot id: A0A376E3V5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1074000:AFK65 RS15570
gene id: 1074000:AFK65_RS15570
uniprot id: A0A376ETK5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS16315
gene id: 1074000:AFK65_RS16315
uniprot id: A0A376EUR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1074000:AFK65 RS10215
gene id: 1074000:AFK65_RS10215
uniprot id: A0A376EH71
names: Similarity
messages: Belongs to the PhzF family.

1074000:AFK65 RS14020
gene id: 1074000:AFK65_RS14020
uniprot id: A0A376ESC5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1074000:AFK65 RS15280
gene id: 1074000:AFK65_RS15280
uniprot id: A0A376EU19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS16400
gene id: 1074000:AFK65_RS16400
uniprot id: A0A376EYD0
names: Similarity
messages: Belongs to the phage portal family. PBSX subfamily.

1074000:AFK65 RS06960
gene id: 1074000:AFK65_RS06960
uniprot id: A0A376E7G8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS12930
gene id: 1074000:AFK65_RS12930
uniprot id: A0A376EP69
names: Similarity
messages: Belongs to the UPF0053 family.

1074000:AFK65 RS13635
gene id: 1074000:AFK65_RS13635
uniprot id: A0A376EPM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

1074000:AFK65 RS13205
gene id: 1074000:AFK65_RS13205
uniprot id: A0A376EMG1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS07335
gene id: 1074000:AFK65_RS07335
uniprot id: A0A376E8Q0
names: Function
names: Similarity
messages: Belongs to the RutC family.
messages: Involved in pyrimidine catabolism. Catalyzes the deamination of 3-aminoacrylate to malonic semialdehyde, a reaction that can also occur spontaneously. RutC may facilitate the reaction and modulate the metabolic fitness, rather than catalyzing essential functions.

1074000:AFK65 RS12390
gene id: 1074000:AFK65_RS12390
uniprot id: A0A376EKT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

1074000:AFK65 RS03970
gene id: 1074000:AFK65_RS03970
uniprot id: A0A376E3J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1074000:AFK65 RS18185
gene id: 1074000:AFK65_RS18185
uniprot id: A0A376EZP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

1074000:AFK65 RS15965
gene id: 1074000:AFK65_RS15965
uniprot id: A0A376EW95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
messages: Belongs to the ZapA family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

1074000:AFK65 RS10840
gene id: 1074000:AFK65_RS10840
uniprot id: A0A376EIH0
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

1074000:AFK65 RS20010
gene id: 1074000:AFK65_RS20010
uniprot id: A0A376KPV6
names: Similarity
messages: Belongs to the DinB family.

1074000:AFK65 RS13105
gene id: 1074000:AFK65_RS13105
uniprot id: A0A376EPJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS14225
gene id: 1074000:AFK65_RS14225
uniprot id: A0A376ER41
names: Similarity
messages: Belongs to the acetyltransferase family. YpeA subfamily.

1074000:AFK65 RS02165
gene id: 1074000:AFK65_RS02165
uniprot id: A0A376DYZ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1074000:AFK65 RS17520
gene id: 1074000:AFK65_RS17520
uniprot id: A0A376EWU7
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

1074000:AFK65 RS01410
gene id: 1074000:AFK65_RS01410
uniprot id: A0A376DZJ3
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

1074000:AFK65 RS06060
gene id: 1074000:AFK65_RS06060
uniprot id: A0A376E6Z2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

1074000:AFK65 RS02020
gene id: 1074000:AFK65_RS02020
uniprot id: A0A376DZ13
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1074000:AFK65 RS03835
gene id: 1074000:AFK65_RS03835
uniprot id: A0A376E3C4
names: Similarity
messages: Belongs to the SfsA family.

1074000:AFK65 RS05715
gene id: 1074000:AFK65_RS05715
uniprot id: A0A376E738
names: Similarity
messages: Belongs to the RNase T2 family.

1074000:AFK65 RS00685
gene id: 1074000:AFK65_RS00685
uniprot id: A0A376DWY8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1074000:AFK65 RS11230
gene id: 1074000:AFK65_RS11230
uniprot id: A0A376EHS6
names: Similarity
messages: Belongs to the UPF0225 family.

1074000:AFK65 RS13190
gene id: 1074000:AFK65_RS13190
uniprot id: A0A376EMQ1
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS16740
gene id: 1074000:AFK65_RS16740
uniprot id: A0A376EYI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS03645
gene id: 1074000:AFK65_RS03645
uniprot id: A0A376E1E4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapD family.
messages: Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
messages: Cytoplasm
messages: Interacts with FtsZ.

1074000:AFK65 RS12740
gene id: 1074000:AFK65_RS12740
uniprot id: A0A376EP79
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme.
messages: Feedback inhibited by histidine.

1074000:AFK65 RS07510
gene id: 1074000:AFK65_RS07510
uniprot id: A0A376E984
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. OpgH subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
messages: Membrane

1074000:AFK65 RS01590
gene id: 1074000:AFK65_RS01590
uniprot id: A0A376DY67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1074000:AFK65 RS05870
gene id: 1074000:AFK65_RS05870
uniprot id: A0A376E4Y4
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

1074000:AFK65 RS02595
gene id: 1074000:AFK65_RS02595
uniprot id: A0A376DZZ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

1074000:AFK65 RS07205
gene id: 1074000:AFK65_RS07205
uniprot id: A0A376E9I3
names: Function
names: Induction
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the SulA family.
messages: By DNA damage, as part of the SOS response.
messages: Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
messages: Interacts with FtsZ.
messages: Is rapidly cleaved and degraded by the Lon protease once DNA damage is repaired.

1074000:AFK65 RS07150
gene id: 1074000:AFK65_RS07150
uniprot id: A0A376E8B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapC family.
messages: Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.
messages: Cytoplasm
messages: Interacts directly with FtsZ.

1074000:AFK65 RS14435
gene id: 1074000:AFK65_RS14435
uniprot id: A0A376ERM3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1074000:AFK65 RS11620
gene id: 1074000:AFK65_RS11620
uniprot id: A0A376EJ89
names: Similarity
messages: Belongs to the UPF0260 family.

1074000:AFK65 RS15530
gene id: 1074000:AFK65_RS15530
uniprot id: A0A376EUA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Syd family.
messages: Cell inner membrane
messages: Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.

1074000:AFK65 RS19750
gene id: 1074000:AFK65_RS19750
uniprot id: A0A376EZ67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

1074000:AFK65 RS13390
gene id: 1074000:AFK65_RS13390
uniprot id: A0A376EQQ4
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane
messages: To H.influenzae HI_0842.

1074000:AFK65 RS13320
gene id: 1074000:AFK65_RS13320
uniprot id: A0A376EPJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxT phosphotransferase family.
messages: Cell inner membrane
messages: Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1-diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P).

1074000:AFK65 RS13760
gene id: 1074000:AFK65_RS13760
uniprot id: A0A376EQJ5
names: Similarity
messages: Belongs to the MbcT/ParT/Res family.

1074000:AFK65 RS09015
gene id: 1074000:AFK65_RS09015
uniprot id: A0A376EF45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxine kinase family. PdxY subfamily.
messages: Homodimer.
messages: Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP.

1074000:AFK65 RS02475
gene id: 1074000:AFK65_RS02475
uniprot id: A0A376DZL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily.
messages: Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4-aminobutanal. Also functions as a cadaverine transaminase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
messages: Homodimer.

1074000:AFK65 RS06235
gene id: 1074000:AFK65_RS06235
uniprot id: A0A376E5N4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Homodimer.

1074000:AFK65 RS15945
gene id: 1074000:AFK65_RS15945
uniprot id: A0A376EW74
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

1074000:AFK65 RS06115
gene id: 1074000:AFK65_RS06115
uniprot id: A0A376E628
names: Function
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

1074000:AFK65 RS18520
gene id: 1074000:AFK65_RS18520
uniprot id: A0A376F037
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS17665
gene id: 1074000:AFK65_RS17665
uniprot id: A0A376EX15
names: Similarity
messages: Belongs to the aspartokinase family.

1074000:AFK65 RS19780
gene id: 1074000:AFK65_RS19780
uniprot id: A0A376F1T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1074000:AFK65 RS00495
gene id: 1074000:AFK65_RS00495
uniprot id: A0A376DWE1
names: Cofactor
names: Function
messages: Binds 4 [4Fe-4S] clusters per subunit.
messages: The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.

1074000:AFK65 RS15195
gene id: 1074000:AFK65_RS15195
uniprot id: A0A376ESP3
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS15400
gene id: 1074000:AFK65_RS15400
uniprot id: A0A376ETY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsB family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

1074000:AFK65 RS18270
gene id: 1074000:AFK65_RS18270
uniprot id: A0A376EZT3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

1074000:AFK65 RS03555
gene id: 1074000:AFK65_RS03555
uniprot id: A0A376E296
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsL family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Membrane
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

1074000:AFK65 RS17285
gene id: 1074000:AFK65_RS17285
uniprot id: A0A376EX90
names: Similarity
messages: Belongs to the EcnA/EcnB lipoprotein family.

1074000:AFK65 RS07195
gene id: 1074000:AFK65_RS07195
uniprot id: A0A376E9B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MatP family.
messages: Cytoplasm
messages: Homodimer.
messages: Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.

1074000:AFK65 RS08255
gene id: 1074000:AFK65_RS08255
uniprot id: A0A376EAV1
names: Function
names: Similarity
messages: Belongs to the arginine N-succinyltransferase family.
messages: Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine.

1074000:AFK65 RS00720
gene id: 1074000:AFK65_RS00720
uniprot id: A0A376DYX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Membrane

1074000:AFK65 RS16120
gene id: 1074000:AFK65_RS16120
uniprot id: A0A376EV07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1074000:AFK65 RS03770
gene id: 1074000:AFK65_RS03770
uniprot id: A0A376E1W8
names: Similarity
messages: Belongs to the bacterial PQQ dehydrogenase family.

1074000:AFK65 RS02060
gene id: 1074000:AFK65_RS02060
uniprot id: A0A376E0A4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).

1074000:AFK65 RS06090
gene id: 1074000:AFK65_RS06090
uniprot id: A0A376E5V1
names: Similarity
messages: Belongs to the citrate synthase family.

1074000:AFK65 RS03430
gene id: 1074000:AFK65_RS03430
uniprot id: A0A376E168
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptD family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptE and LptA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.

1074000:AFK65 RS17160
gene id: 1074000:AFK65_RS17160
uniprot id: A0A376EYQ1
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

1074000:AFK65 RS17245
gene id: 1074000:AFK65_RS17245
uniprot id: A0A376EZW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
messages: Homodimer.
messages: With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P.

1074000:AFK65 RS00860
gene id: 1074000:AFK65_RS00860
uniprot id: A0A376DZ79
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1074000:AFK65 RS04220
gene id: 1074000:AFK65_RS04220
uniprot id: A0A376E3B9
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

1074000:AFK65 RS07960
gene id: 1074000:AFK65_RS07960
uniprot id: A0A376EBD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CopD family.
messages: Cell inner membrane
messages: Involved in copper resistance.
messages: Membrane

1074000:AFK65 RS00585
gene id: 1074000:AFK65_RS00585
uniprot id: A0A376DWK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.

1074000:AFK65 RS02515
gene id: 1074000:AFK65_RS02515
uniprot id: A0A376E1B6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2).
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

1074000:AFK65 RS00115
gene id: 1074000:AFK65_RS00115
uniprot id: A0A376DVN7
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

1074000:AFK65 RS07340
gene id: 1074000:AFK65_RS07340
uniprot id: A0A376E9J8
names: Function
names: Similarity
messages: Belongs to the isochorismatase family. RutB subfamily.
messages: Hydrolyzes ureidoacrylate to form aminoacrylate and carbamate. The carbamate hydrolyzes spontaneously, thereby releasing one of the nitrogen atoms of the pyrimidine ring as ammonia and one of its carbon atoms as CO2.

1074000:AFK65 RS19790
gene id: 1074000:AFK65_RS19790
uniprot id: A0A376F2C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1074000:AFK65 RS06745
gene id: 1074000:AFK65_RS06745
uniprot id: A0A376E7R9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine.

1074000:AFK65 RS17855
gene id: 1074000:AFK65_RS17855
uniprot id: A0A376EXX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1074000:AFK65 RS18285
gene id: 1074000:AFK65_RS18285
uniprot id: A0A376F039
names: Subcellular Location Annotation
messages: Cell inner membrane

1074000:AFK65 RS03040
gene id: 1074000:AFK65_RS03040
uniprot id: A0A376E0V2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

1074000:AFK65 RS07125
gene id: 1074000:AFK65_RS07125
uniprot id: A0A376E7V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS08225
gene id: 1074000:AFK65_RS08225
uniprot id: A0A376EBJ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

1074000:AFK65 RS16280
gene id: 1074000:AFK65_RS16280
uniprot id: A0A376EUU5
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Comprises two domains: an N-terminal domain containing the nucleotidyltransferase activity and a C-terminal HD domain associated with both phosphodiesterase and phosphatase activities.
messages: Magnesium is required for nucleotidyltransferase activity.
messages: Monomer. Can also form homodimers and oligomers.
messages: Nickel for phosphatase activity.

1074000:AFK65 RS15505
gene id: 1074000:AFK65_RS15505
uniprot id: A0A376EU86
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.

1074000:AFK65 RS07800
gene id: 1074000:AFK65_RS07800
uniprot id: A0A376EAA4
names: Similarity
messages: Belongs to the UPF0227 family.

1074000:AFK65 RS05195
gene id: 1074000:AFK65_RS05195
uniprot id: A0A376E4E6
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

1074000:AFK65 RS15770
gene id: 1074000:AFK65_RS15770
uniprot id: A0A376ETC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1074000:AFK65 RS15205
gene id: 1074000:AFK65_RS15205
uniprot id: A0A376ESQ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

1074000:AFK65 RS10190
gene id: 1074000:AFK65_RS10190
uniprot id: A0A376EFD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane

1074000:AFK65 RS18150
gene id: 1074000:AFK65_RS18150
uniprot id: A0A376EXJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

1074000:AFK65 RS09910
gene id: 1074000:AFK65_RS09910
uniprot id: A0A376EG63
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

1074000:AFK65 RS13125
gene id: 1074000:AFK65_RS13125
uniprot id: A0A376EPM1
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

1074000:AFK65 RS08495
gene id: 1074000:AFK65_RS08495
uniprot id: A0A376ECE2
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1074000:AFK65 RS07370
gene id: 1074000:AFK65_RS07370
uniprot id: A0A376E9S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

1074000:AFK65 RS01005
gene id: 1074000:AFK65_RS01005
uniprot id: A0A376DXB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrbI/VirB10 family.
messages: Membrane

1074000:AFK65 RS14890
gene id: 1074000:AFK65_RS14890
uniprot id: A0A376ET25
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.

1074000:AFK65 RS17330
gene id: 1074000:AFK65_RS17330
uniprot id: A0A376EYL7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CutA family.
messages: Binds 1 copper ion per subunit.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in resistance toward heavy metals.

1074000:AFK65 RS18200
gene id: 1074000:AFK65_RS18200
uniprot id: A0A376EXL7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1074000:AFK65 RS12065
gene id: 1074000:AFK65_RS12065
uniprot id: A0A376EK20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

1074000:AFK65 RS05065
gene id: 1074000:AFK65_RS05065
uniprot id: A0A376E5B5
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

1074000:AFK65 RS04635
gene id: 1074000:AFK65_RS04635
uniprot id: A0A376E3G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS03925
gene id: 1074000:AFK65_RS03925
uniprot id: A0A376E294
names: Activity Regulation
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

1074000:AFK65 RS14170
gene id: 1074000:AFK65_RS14170
uniprot id: A0A376EPL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

1074000:AFK65 RS04330
gene id: 1074000:AFK65_RS04330
uniprot id: A0A376E2W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

1074000:AFK65 RS03890
gene id: 1074000:AFK65_RS03890
uniprot id: A0A376E202
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1074000:AFK65 RS17175
gene id: 1074000:AFK65_RS17175
uniprot id: A0A376EZR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

1074000:AFK65 RS14295
gene id: 1074000:AFK65_RS14295
uniprot id: A0A376ERB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

1074000:AFK65 RS12470
gene id: 1074000:AFK65_RS12470
uniprot id: A0A376ELH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

1074000:AFK65 RS00675
gene id: 1074000:AFK65_RS00675
uniprot id: A0A376DXK2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1074000:AFK65 RS20155
gene id: 1074000:AFK65_RS20155
uniprot id: A0A376KQ45
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

1074000:AFK65 RS13685
gene id: 1074000:AFK65_RS13685
uniprot id: A0A376ERE8
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS13920
gene id: 1074000:AFK65_RS13920
uniprot id: A0A376EQE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

1074000:AFK65 RS19395
gene id: 1074000:AFK65_RS19395
uniprot id: A0A376F1V9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

1074000:AFK65 RS07600
gene id: 1074000:AFK65_RS07600
uniprot id: A0A376E9H1
names: Function
names: Similarity
messages: Belongs to the FlgN family.
messages: Required for the efficient initiation of filament assembly.

1074000:AFK65 RS12440
gene id: 1074000:AFK65_RS12440
uniprot id: A0A376EMZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively.

1074000:AFK65 RS12480
gene id: 1074000:AFK65_RS12480
uniprot id: A0A376EKX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell membrane
messages: FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

1074000:AFK65 RS15025
gene id: 1074000:AFK65_RS15025
uniprot id: A0A376ETB3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

1074000:AFK65 RS06795
gene id: 1074000:AFK65_RS06795
uniprot id: A0A376E9R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Periplasm

1074000:AFK65 RS03895
gene id: 1074000:AFK65_RS03895
uniprot id: A0A376E284
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BtuF family.
messages: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).

1074000:AFK65 RS07070
gene id: 1074000:AFK65_RS07070
uniprot id: A0A376EAF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MukE family.
messages: Interacts, and probably forms a ternary complex, with MukF and MukB. The complex formation is stimulated by calcium or magnesium.
messages: Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF.
messages: nucleoid

1074000:AFK65 RS10015
gene id: 1074000:AFK65_RS10015
uniprot id: A0A376EFP8
names: Similarity
messages: Belongs to the peptidase C40 family.

1074000:AFK65 RS13565
gene id: 1074000:AFK65_RS13565
uniprot id: A0A376EN85
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

1074000:AFK65 RS02220
gene id: 1074000:AFK65_RS02220
uniprot id: A0A376DZ17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

1074000:AFK65 RS15630
gene id: 1074000:AFK65_RS15630
uniprot id: A0A376EVB7
names: Function
names: Similarity
messages: Belongs to the peptidase M16 family.
messages: Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin.

1074000:AFK65 RS17565
gene id: 1074000:AFK65_RS17565
uniprot id: A0A376EZ06
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

1074000:AFK65 RS06240
gene id: 1074000:AFK65_RS06240
uniprot id: A0A376E5N3
names: Similarity
messages: Belongs to the aldose epimerase family.

1074000:AFK65 RS05305
gene id: 1074000:AFK65_RS05305
uniprot id: A0A376E475
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

1074000:AFK65 RS01870
gene id: 1074000:AFK65_RS01870
uniprot id: A0A376DYU5
names: Function
names: Similarity
messages: Belongs to the peptidase U62 family.
messages: Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA).

1074000:AFK65 RS11485
gene id: 1074000:AFK65_RS11485
uniprot id: A0A376EIR2
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1074000:AFK65 RS19650
gene id: 1074000:AFK65_RS19650
uniprot id: A0A376F268
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1074000:AFK65 RS03980
gene id: 1074000:AFK65_RS03980
uniprot id: A0A376E237
names: Similarity
messages: Belongs to the skp family.

1074000:AFK65 RS19190
gene id: 1074000:AFK65_RS19190
uniprot id: A0A376EYU5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.

1074000:AFK65 RS11580
gene id: 1074000:AFK65_RS11580
uniprot id: A0A376EIA5
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1074000:AFK65 RS19365
gene id: 1074000:AFK65_RS19365
uniprot id: A0A376F127
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1074000:AFK65 RS14080
gene id: 1074000:AFK65_RS14080
uniprot id: A0A376EPW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

1074000:AFK65 RS07640
gene id: 1074000:AFK65_RS07640
uniprot id: A0A376EBK3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

1074000:AFK65 RS15145
gene id: 1074000:AFK65_RS15145
uniprot id: A0A376ERU1
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

1074000:AFK65 RS06210
gene id: 1074000:AFK65_RS06210
uniprot id: A0A376E629
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1074000:AFK65 RS06250
gene id: 1074000:AFK65_RS06250
uniprot id: A0A376E8B0
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.
messages: Binds 1 zinc ion per subunit.

1074000:AFK65 RS15750
gene id: 1074000:AFK65_RS15750
uniprot id: A0A376EW63
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

1074000:AFK65 RS01285
gene id: 1074000:AFK65_RS01285
uniprot id: A0A376DZX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-1 family.
messages: Cytoplasm

1074000:AFK65 RS18745
gene id: 1074000:AFK65_RS18745
uniprot id: A0A376EYF5
names: Similarity
messages: Belongs to the CcdB toxin family.

1074000:AFK65 RS10960
gene id: 1074000:AFK65_RS10960
uniprot id: A0A376EHQ5
names: Similarity
messages: Belongs to the UPF0509 family.

1074000:AFK65 RS02310
gene id: 1074000:AFK65_RS02310
uniprot id: A0A376E0Z0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1074000:AFK65 RS14790
gene id: 1074000:AFK65_RS14790
uniprot id: A0A376ETD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

1074000:AFK65 RS07525
gene id: 1074000:AFK65_RS07525
uniprot id: A0A376E9K6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxL/LpxM/LpxP family.
messages: Catalyzes the transfer of an acyl chain from an acyl-[acyl-carrier-protein] (ACP) to a Kdo(2)-lipid IV(A) to form a Kdo(2)-(acyl)-lipid IV(A).
messages: Cell inner membrane

1074000:AFK65 RS00450
gene id: 1074000:AFK65_RS00450
uniprot id: A0A376DWB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers. Binds only one seryl-tRNA(Sec) per dimer.

1074000:AFK65 RS00655
gene id: 1074000:AFK65_RS00655
uniprot id: A0A376DY52
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

1074000:AFK65 RS06320
gene id: 1074000:AFK65_RS06320
uniprot id: A0A376E602
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

1074000:AFK65 RS07030
gene id: 1074000:AFK65_RS07030
uniprot id: A0A376E8G2
names: Similarity
messages: Belongs to the UPF0434 family.

1074000:AFK65 RS16570
gene id: 1074000:AFK65_RS16570
uniprot id: A0A376EX88
names: Subcellular Location Annotation
messages: Cytoplasm

1074000:AFK65 RS03660
gene id: 1074000:AFK65_RS03660
uniprot id: A0A376E1H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Membrane

1074000:AFK65 RS05015
gene id: 1074000:AFK65_RS05015
uniprot id: A0A376E3J9
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS08805
gene id: 1074000:AFK65_RS08805
uniprot id: A0A376EBQ8
names: Subcellular Location Annotation
messages: Membrane

1074000:AFK65 RS06010
gene id: 1074000:AFK65_RS06010
uniprot id: A0A376E6Z0
names: Subcellular Location Annotation
messages: Membrane