1041930:MTC RS11415
gene id: 1041930:MTC_RS11415
uniprot id: H8IB10
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS10850
gene id: 1041930:MTC_RS10850
uniprot id: H8I9V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.
messages: Membrane

1041930:MTC RS09190
gene id: 1041930:MTC_RS09190
uniprot id: H8IAS9
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1041930:MTC RS04115
gene id: 1041930:MTC_RS04115
uniprot id: H8IAA7
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS06890
gene id: 1041930:MTC_RS06890
uniprot id: H8IAP1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1041930:MTC RS05720
gene id: 1041930:MTC_RS05720
uniprot id: H8I7R8
names: Similarity
messages: Belongs to the PspA/IM30 family.

1041930:MTC RS07745
gene id: 1041930:MTC_RS07745
uniprot id: H8I755
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS03980
gene id: 1041930:MTC_RS03980
uniprot id: H8I9D7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1041930:MTC RS11235
gene id: 1041930:MTC_RS11235
uniprot id: H8IAX6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1041930:MTC RS05020
gene id: 1041930:MTC_RS05020
uniprot id: H8I5U5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1041930:MTC RS02575
gene id: 1041930:MTC_RS02575
uniprot id: H8I583
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

1041930:MTC RS12060
gene id: 1041930:MTC_RS12060
uniprot id: H8I6E9
names: Similarity
messages: Belongs to the glutamate synthase family.

1041930:MTC RS11250
gene id: 1041930:MTC_RS11250
uniprot id: H8IAX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1041930:MTC RS06640
gene id: 1041930:MTC_RS06640
uniprot id: H8IAJ2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

1041930:MTC RS09510
gene id: 1041930:MTC_RS09510
uniprot id: H8I4Q6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

1041930:MTC RS10750
gene id: 1041930:MTC_RS10750
uniprot id: H8I871
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

1041930:MTC RS00290
gene id: 1041930:MTC_RS00290
uniprot id: H8I5D8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1041930:MTC RS10665
gene id: 1041930:MTC_RS10665
uniprot id: H8I855
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

1041930:MTC RS00265
gene id: 1041930:MTC_RS00265
uniprot id: H8I5D3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

1041930:MTC RS06050
gene id: 1041930:MTC_RS06050
uniprot id: H8I8R6
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

1041930:MTC RS10035
gene id: 1041930:MTC_RS10035
uniprot id: H8I6A7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

1041930:MTC RS06805
gene id: 1041930:MTC_RS06805
uniprot id: H8IAM3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

1041930:MTC RS02250
gene id: 1041930:MTC_RS02250
uniprot id: H8I477
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS02525
gene id: 1041930:MTC_RS02525
uniprot id: H8I573
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

1041930:MTC RS00995
gene id: 1041930:MTC_RS00995
uniprot id: H8I8B5
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS09105
gene id: 1041930:MTC_RS09105
uniprot id: H8IAR4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1041930:MTC RS07950
gene id: 1041930:MTC_RS07950
uniprot id: H8I7U7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

1041930:MTC RS11685
gene id: 1041930:MTC_RS11685
uniprot id: H8I4X9
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

1041930:MTC RS11405
gene id: 1041930:MTC_RS11405
uniprot id: H8IB08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

1041930:MTC RS06930
gene id: 1041930:MTC_RS06930
uniprot id: H8I4G7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1041930:MTC RS03130
gene id: 1041930:MTC_RS03130
uniprot id: H8I6R3
names: Function
messages: Involved in the transposition of the insertion sequence IS5.

1041930:MTC RS10715
gene id: 1041930:MTC_RS10715
uniprot id: H8I864
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

1041930:MTC RS06700
gene id: 1041930:MTC_RS06700
uniprot id: H8IAK4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

1041930:MTC RS01930
gene id: 1041930:MTC_RS01930
uniprot id: H8IA88
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

1041930:MTC RS01625
gene id: 1041930:MTC_RS01625
uniprot id: H8IA27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

1041930:MTC RS01765
gene id: 1041930:MTC_RS01765
uniprot id: H8IA55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1041930:MTC RS11175
gene id: 1041930:MTC_RS11175
uniprot id: H8IA13
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS00910
gene id: 1041930:MTC_RS00910
uniprot id: H8I898
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

1041930:MTC RS07390
gene id: 1041930:MTC_RS07390
uniprot id: H8I602
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1041930:MTC RS01115
gene id: 1041930:MTC_RS01115
uniprot id: H8I8D9
names: Similarity
messages: Belongs to the HisA/HisF family.

1041930:MTC RS00750
gene id: 1041930:MTC_RS00750
uniprot id: H8I6M5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

1041930:MTC RS07205
gene id: 1041930:MTC_RS07205
uniprot id: H8I4M2
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS02520
gene id: 1041930:MTC_RS02520
uniprot id: H8I572
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

1041930:MTC RS06655
gene id: 1041930:MTC_RS06655
uniprot id: H8IAJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1041930:MTC RS02940
gene id: 1041930:MTC_RS02940
uniprot id: H8I5M7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1041930:MTC RS09685
gene id: 1041930:MTC_RS09685
uniprot id: H8I4U3
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

1041930:MTC RS07910
gene id: 1041930:MTC_RS07910
uniprot id: H8I788
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1041930:MTC RS01795
gene id: 1041930:MTC_RS01795
uniprot id: H8IA61
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS04870
gene id: 1041930:MTC_RS04870
uniprot id: H8I5R6
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1041930:MTC RS09195
gene id: 1041930:MTC_RS09195
uniprot id: H8IAT0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1041930:MTC RS00805
gene id: 1041930:MTC_RS00805
uniprot id: H8I6N6
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS06665
gene id: 1041930:MTC_RS06665
uniprot id: H8IAJ7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

1041930:MTC RS03295
gene id: 1041930:MTC_RS03295
uniprot id: H8I6U8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS07715
gene id: 1041930:MTC_RS07715
uniprot id: H8I750
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS07400
gene id: 1041930:MTC_RS07400
uniprot id: H8I604
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1041930:MTC RS01035
gene id: 1041930:MTC_RS01035
uniprot id: H8I8C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1041930:MTC RS11180
gene id: 1041930:MTC_RS11180
uniprot id: H8IA14
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1041930:MTC RS06760
gene id: 1041930:MTC_RS06760
uniprot id: H8IAL5
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1041930:MTC RS09440
gene id: 1041930:MTC_RS09440
uniprot id: H8I4P1
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS01820
gene id: 1041930:MTC_RS01820
uniprot id: H8IA66
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1041930:MTC RS02870
gene id: 1041930:MTC_RS02870
uniprot id: H8I5L4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1041930:MTC RS07665
gene id: 1041930:MTC_RS07665
uniprot id: H8I739
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1041930:MTC RS03595
gene id: 1041930:MTC_RS03595
uniprot id: H8I8K2
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS12185
gene id: 1041930:MTC_RS12185
uniprot id: H8I6H3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1041930:MTC RS03545
gene id: 1041930:MTC_RS03545
uniprot id: H8I8J2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS07630
gene id: 1041930:MTC_RS07630
uniprot id: H8I733
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1041930:MTC RS06990
gene id: 1041930:MTC_RS06990
uniprot id: H8I4H9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1041930:MTC RS06950
gene id: 1041930:MTC_RS06950
uniprot id: H8I4H1
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

1041930:MTC RS04795
gene id: 1041930:MTC_RS04795
uniprot id: H8I5Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

1041930:MTC RS05450
gene id: 1041930:MTC_RS05450
uniprot id: H8I720
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

1041930:MTC RS04610
gene id: 1041930:MTC_RS04610
uniprot id: H8I4C2
names: Similarity
messages: Belongs to the UPF0251 family.

1041930:MTC RS10050
gene id: 1041930:MTC_RS10050
uniprot id: H8I6B0
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS04490
gene id: 1041930:MTC_RS04490
uniprot id: H8I498
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

1041930:MTC RS04130
gene id: 1041930:MTC_RS04130
uniprot id: H8IAB0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS02195
gene id: 1041930:MTC_RS02195
uniprot id: H8I466
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

1041930:MTC RS01815
gene id: 1041930:MTC_RS01815
uniprot id: H8IA65
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

1041930:MTC RS11845
gene id: 1041930:MTC_RS11845
uniprot id: H8I512
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1041930:MTC RS12420
gene id: 1041930:MTC_RS12420
uniprot id: H8I7K7
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

1041930:MTC RS01635
gene id: 1041930:MTC_RS01635
uniprot id: H8IA29
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1041930:MTC RS08570
gene id: 1041930:MTC_RS08570
uniprot id: H8I8Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

1041930:MTC RS00730
gene id: 1041930:MTC_RS00730
uniprot id: H8I6M1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-97 inactivates the nitrogenase reductase and regulates nitrogenase activity.

1041930:MTC RS13675
gene id: 1041930:MTC_RS13675
uniprot id: H8I9Z4
names: Caution
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS08295
gene id: 1041930:MTC_RS08295
uniprot id: H8I8U5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1041930:MTC RS05260
gene id: 1041930:MTC_RS05260
uniprot id: H8I6Y1
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

1041930:MTC RS00705
gene id: 1041930:MTC_RS00705
uniprot id: H8I6L7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

1041930:MTC RS01480
gene id: 1041930:MTC_RS01480
uniprot id: H8I961
names: Similarity
messages: Belongs to the UPF0210 family.

1041930:MTC RS06800
gene id: 1041930:MTC_RS06800
uniprot id: H8IAM2
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

1041930:MTC RS09435
gene id: 1041930:MTC_RS09435
uniprot id: H8I4P0
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS07070
gene id: 1041930:MTC_RS07070
uniprot id: H8I4J5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1041930:MTC RS01245
gene id: 1041930:MTC_RS01245
uniprot id: H8I914
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

1041930:MTC RS06995
gene id: 1041930:MTC_RS06995
uniprot id: H8I4I0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

1041930:MTC RS06510
gene id: 1041930:MTC_RS06510
uniprot id: H8I9L9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

1041930:MTC RS00885
gene id: 1041930:MTC_RS00885
uniprot id: H8I893
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS07830
gene id: 1041930:MTC_RS07830
uniprot id: H8I772
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS05795
gene id: 1041930:MTC_RS05795
uniprot id: H8I7T3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

1041930:MTC RS05095
gene id: 1041930:MTC_RS05095
uniprot id: H8I5V9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1041930:MTC RS01505
gene id: 1041930:MTC_RS01505
uniprot id: H8I966
names: Similarity
messages: Belongs to the acylphosphatase family.

1041930:MTC RS12065
gene id: 1041930:MTC_RS12065
uniprot id: H8I6F0
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS03510
gene id: 1041930:MTC_RS03510
uniprot id: H8I8I6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1041930:MTC RS07930
gene id: 1041930:MTC_RS07930
uniprot id: H8I792
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS11160
gene id: 1041930:MTC_RS11160
uniprot id: H8IA10
names: Similarity
messages: Belongs to the AOR/FOR family.

1041930:MTC RS07010
gene id: 1041930:MTC_RS07010
uniprot id: H8I4I3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS06695
gene id: 1041930:MTC_RS06695
uniprot id: H8IAK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1041930:MTC RS11965
gene id: 1041930:MTC_RS11965
uniprot id: H8I6D0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

1041930:MTC RS09955
gene id: 1041930:MTC_RS09955
uniprot id: H8I691
names: Similarity
messages: Belongs to the DEAD box helicase family.

1041930:MTC RS05690
gene id: 1041930:MTC_RS05690
uniprot id: H8I7R2
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS08925
gene id: 1041930:MTC_RS08925
uniprot id: H8I9T3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS10655
gene id: 1041930:MTC_RS10655
uniprot id: H8I853
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1041930:MTC RS01865
gene id: 1041930:MTC_RS01865
uniprot id: H8IA75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

1041930:MTC RS04090
gene id: 1041930:MTC_RS04090
uniprot id: H8IAA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

1041930:MTC RS04455
gene id: 1041930:MTC_RS04455
uniprot id: H8IAH4
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS08420
gene id: 1041930:MTC_RS08420
uniprot id: H8I8X0
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS02345
gene id: 1041930:MTC_RS02345
uniprot id: H8I537
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

1041930:MTC RS05865
gene id: 1041930:MTC_RS05865
uniprot id: H8I8M9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

1041930:MTC RS00245
gene id: 1041930:MTC_RS00245
uniprot id: H8I5C9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1041930:MTC RS11695
gene id: 1041930:MTC_RS11695
uniprot id: H8I4Y1
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

1041930:MTC RS03600
gene id: 1041930:MTC_RS03600
uniprot id: H8I8K3
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS10430
gene id: 1041930:MTC_RS10430
uniprot id: H8I7G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1041930:MTC RS09210
gene id: 1041930:MTC_RS09210
uniprot id: H8IAT3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1041930:MTC RS05370
gene id: 1041930:MTC_RS05370
uniprot id: H8I703
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

1041930:MTC RS07995
gene id: 1041930:MTC_RS07995
uniprot id: H8I7V5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS04155
gene id: 1041930:MTC_RS04155
uniprot id: H8IAB5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

1041930:MTC RS06105
gene id: 1041930:MTC_RS06105
uniprot id: H8I8S7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS04140
gene id: 1041930:MTC_RS04140
uniprot id: H8IAB2
names: Subcellular Location Annotation
messages: Cytoplasm

1041930:MTC RS07575
gene id: 1041930:MTC_RS07575
uniprot id: H8I639
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

1041930:MTC RS11005
gene id: 1041930:MTC_RS11005
uniprot id: H8I9Y1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1041930:MTC RS02420
gene id: 1041930:MTC_RS02420
uniprot id: H8I552
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS00745
gene id: 1041930:MTC_RS00745
uniprot id: H8I6M4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

1041930:MTC RS02675
gene id: 1041930:MTC_RS02675
uniprot id: H8I5H7
names: Similarity
messages: Belongs to the IlvD/Edd family.

1041930:MTC RS10070
gene id: 1041930:MTC_RS10070
uniprot id: H8I795
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1041930:MTC RS03985
gene id: 1041930:MTC_RS03985
uniprot id: H8I9D8
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS10400
gene id: 1041930:MTC_RS10400
uniprot id: H8I7F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1041930:MTC RS11240
gene id: 1041930:MTC_RS11240
uniprot id: H8IAX7
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

1041930:MTC RS02255
gene id: 1041930:MTC_RS02255
uniprot id: H8I478
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS04295
gene id: 1041930:MTC_RS04295
uniprot id: H8IAE3
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

1041930:MTC RS10760
gene id: 1041930:MTC_RS10760
uniprot id: H8I873
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1041930:MTC RS05055
gene id: 1041930:MTC_RS05055
uniprot id: H8I5V1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

1041930:MTC RS02450
gene id: 1041930:MTC_RS02450
uniprot id: H8I558
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1041930:MTC RS05640
gene id: 1041930:MTC_RS05640
uniprot id: H8I7Q2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS12025
gene id: 1041930:MTC_RS12025
uniprot id: H8I6E2
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS02210
gene id: 1041930:MTC_RS02210
uniprot id: H8I469
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1041930:MTC RS11810
gene id: 1041930:MTC_RS11810
uniprot id: H8I504
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS07075
gene id: 1041930:MTC_RS07075
uniprot id: H8I4J6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

1041930:MTC RS06575
gene id: 1041930:MTC_RS06575
uniprot id: H8IAH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

1041930:MTC RS05495
gene id: 1041930:MTC_RS05495
uniprot id: H8I7M3
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS04675
gene id: 1041930:MTC_RS04675
uniprot id: H8I4D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1041930:MTC RS07760
gene id: 1041930:MTC_RS07760
uniprot id: H8I758
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

1041930:MTC RS00920
gene id: 1041930:MTC_RS00920
uniprot id: H8I8A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1041930:MTC RS11960
gene id: 1041930:MTC_RS11960
uniprot id: H8I6C9
names: Similarity
messages: Belongs to the P(II) protein family.

1041930:MTC RS04565
gene id: 1041930:MTC_RS04565
uniprot id: H8I4B4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1041930:MTC RS06750
gene id: 1041930:MTC_RS06750
uniprot id: H8IAL3
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1041930:MTC RS00165
gene id: 1041930:MTC_RS00165
uniprot id: H8I5B2
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS00425
gene id: 1041930:MTC_RS00425
uniprot id: H8I5G3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1041930:MTC RS04255
gene id: 1041930:MTC_RS04255
uniprot id: H8IAD5
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS01135
gene id: 1041930:MTC_RS01135
uniprot id: H8I8E3
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1041930:MTC RS04520
gene id: 1041930:MTC_RS04520
uniprot id: H8I4A5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

1041930:MTC RS01880
gene id: 1041930:MTC_RS01880
uniprot id: H8IA78
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

1041930:MTC RS10060
gene id: 1041930:MTC_RS10060
uniprot id: H8I6B2
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS07845
gene id: 1041930:MTC_RS07845
uniprot id: H8I775
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS09515
gene id: 1041930:MTC_RS09515
uniprot id: H8I4Q7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

1041930:MTC RS01775
gene id: 1041930:MTC_RS01775
uniprot id: H8IA57
names: Similarity
messages: Belongs to the UPF0280 family.

1041930:MTC RS04430
gene id: 1041930:MTC_RS04430
uniprot id: H8IAG9
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS12485
gene id: 1041930:MTC_RS12485
uniprot id: H8I7L9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

1041930:MTC RS11790
gene id: 1041930:MTC_RS11790
uniprot id: H8I500
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS03690
gene id: 1041930:MTC_RS03690
uniprot id: H8I8M3
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS10905
gene id: 1041930:MTC_RS10905
uniprot id: H8I9W1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1041930:MTC RS02555
gene id: 1041930:MTC_RS02555
uniprot id: H8I579
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS04135
gene id: 1041930:MTC_RS04135
uniprot id: H8IAB1
names: Similarity
messages: Belongs to the GARS family.

1041930:MTC RS07770
gene id: 1041930:MTC_RS07770
uniprot id: H8I760
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1041930:MTC RS12410
gene id: 1041930:MTC_RS12410
uniprot id: H8I7K5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

1041930:MTC RS12415
gene id: 1041930:MTC_RS12415
uniprot id: H8I7K6
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

1041930:MTC RS09135
gene id: 1041930:MTC_RS09135
uniprot id: H8IAR9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1041930:MTC RS11410
gene id: 1041930:MTC_RS11410
uniprot id: H8IB09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

1041930:MTC RS01630
gene id: 1041930:MTC_RS01630
uniprot id: H8IA28
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1041930:MTC RS05150
gene id: 1041930:MTC_RS05150
uniprot id: H8I5X1
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS10620
gene id: 1041930:MTC_RS10620
uniprot id: H8I846
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

1041930:MTC RS01485
gene id: 1041930:MTC_RS01485
uniprot id: H8I962
names: Similarity
messages: Belongs to the UPF0237 family.

1041930:MTC RS01255
gene id: 1041930:MTC_RS01255
uniprot id: H8I916
names: Subcellular Location Annotation
messages: Cytoplasm

1041930:MTC RS13690
gene id: 1041930:MTC_RS13690
uniprot id: H8I6K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

1041930:MTC RS08665
gene id: 1041930:MTC_RS08665
uniprot id: H8I9N6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

1041930:MTC RS10340
gene id: 1041930:MTC_RS10340
uniprot id: H8I7E6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Belongs to the FtsZ family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Monomer.

1041930:MTC RS11770
gene id: 1041930:MTC_RS11770
uniprot id: H8I4Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1041930:MTC RS05755
gene id: 1041930:MTC_RS05755
uniprot id: H8I7S5
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

1041930:MTC RS00640
gene id: 1041930:MTC_RS00640
uniprot id: H8I6K8
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS11555
gene id: 1041930:MTC_RS11555
uniprot id: H8I4V1
names: Similarity
messages: Belongs to the AdoMet synthase family.

1041930:MTC RS00575
gene id: 1041930:MTC_RS00575
uniprot id: H8I6J5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS00710
gene id: 1041930:MTC_RS00710
uniprot id: H8I6L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1041930:MTC RS05050
gene id: 1041930:MTC_RS05050
uniprot id: H8I5V0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS03280
gene id: 1041930:MTC_RS03280
uniprot id: H8I6U5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1041930:MTC RS10015
gene id: 1041930:MTC_RS10015
uniprot id: H8I6A3
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

1041930:MTC RS11815
gene id: 1041930:MTC_RS11815
uniprot id: H8I506
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1041930:MTC RS03580
gene id: 1041930:MTC_RS03580
uniprot id: H8I8J8
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS11660
gene id: 1041930:MTC_RS11660
uniprot id: H8I4X4
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1041930:MTC RS05515
gene id: 1041930:MTC_RS05515
uniprot id: H8I7M7
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

1041930:MTC RS08650
gene id: 1041930:MTC_RS08650
uniprot id: H8I9N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1041930:MTC RS03840
gene id: 1041930:MTC_RS03840
uniprot id: H8I9B1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1041930:MTC RS01380
gene id: 1041930:MTC_RS01380
uniprot id: H8I941
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

1041930:MTC RS02380
gene id: 1041930:MTC_RS02380
uniprot id: H8I544
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS00940
gene id: 1041930:MTC_RS00940
uniprot id: H8I8A4
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

1041930:MTC RS09820
gene id: 1041930:MTC_RS09820
uniprot id: H8I665
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1041930:MTC RS08535
gene id: 1041930:MTC_RS08535
uniprot id: H8I8Z2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1041930:MTC RS08300
gene id: 1041930:MTC_RS08300
uniprot id: H8I8U6
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS09825
gene id: 1041930:MTC_RS09825
uniprot id: H8I666
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1041930:MTC RS01330
gene id: 1041930:MTC_RS01330
uniprot id: H8I931
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

1041930:MTC RS03650
gene id: 1041930:MTC_RS03650
uniprot id: H8I8L4
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS10720
gene id: 1041930:MTC_RS10720
uniprot id: H8I865
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1041930:MTC RS00300
gene id: 1041930:MTC_RS00300
uniprot id: H8I5E0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

1041930:MTC RS12340
gene id: 1041930:MTC_RS12340
uniprot id: H8I7I9
names: Similarity
messages: Belongs to the HdrB family.

1041930:MTC RS04285
gene id: 1041930:MTC_RS04285
uniprot id: H8IAE1
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS09035
gene id: 1041930:MTC_RS09035
uniprot id: H8IAP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1041930:MTC RS00020
gene id: 1041930:MTC_RS00020
uniprot id: H8I520
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1041930:MTC RS01920
gene id: 1041930:MTC_RS01920
uniprot id: H8IA86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1041930:MTC RS07650
gene id: 1041930:MTC_RS07650
uniprot id: H8I736
names: Similarity
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.

1041930:MTC RS05995
gene id: 1041930:MTC_RS05995
uniprot id: H8I8Q4
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1041930:MTC RS04855
gene id: 1041930:MTC_RS04855
uniprot id: H8I5R3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1041930:MTC RS03850
gene id: 1041930:MTC_RS03850
uniprot id: H8I9B3
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1041930:MTC RS12045
gene id: 1041930:MTC_RS12045
uniprot id: H8I6E6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1041930:MTC RS00145
gene id: 1041930:MTC_RS00145
uniprot id: H8I5A8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

1041930:MTC RS12390
gene id: 1041930:MTC_RS12390
uniprot id: H8I7K1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1041930:MTC RS07785
gene id: 1041930:MTC_RS07785
uniprot id: H8I763
names: Similarity
messages: Belongs to the UPF0284 family.

1041930:MTC RS11095
gene id: 1041930:MTC_RS11095
uniprot id: H8I9Z8
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

1041930:MTC RS01805
gene id: 1041930:MTC_RS01805
uniprot id: H8IA63
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

1041930:MTC RS04320
gene id: 1041930:MTC_RS04320
uniprot id: H8IAE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1041930:MTC RS10100
gene id: 1041930:MTC_RS10100
uniprot id: H8I7A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1041930:MTC RS02570
gene id: 1041930:MTC_RS02570
uniprot id: H8I582
names: Similarity
messages: Belongs to the UPF0292 family.

1041930:MTC RS04550
gene id: 1041930:MTC_RS04550
uniprot id: H8I4B1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1041930:MTC RS07275
gene id: 1041930:MTC_RS07275
uniprot id: H8I5Y1
names: Similarity
messages: Belongs to the thioesterase PaaI family.

1041930:MTC RS00010
gene id: 1041930:MTC_RS00010
uniprot id: H8I518
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1041930:MTC RS08105
gene id: 1041930:MTC_RS08105
uniprot id: H8I7X8
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS08310
gene id: 1041930:MTC_RS08310
uniprot id: H8I8U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

1041930:MTC RS08290
gene id: 1041930:MTC_RS08290
uniprot id: H8I8U4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

1041930:MTC RS04180
gene id: 1041930:MTC_RS04180
uniprot id: H8IAC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

1041930:MTC RS10820
gene id: 1041930:MTC_RS10820
uniprot id: H8I885
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

1041930:MTC RS05665
gene id: 1041930:MTC_RS05665
uniprot id: H8I7Q7
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS07765
gene id: 1041930:MTC_RS07765
uniprot id: H8I759
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B.

1041930:MTC RS08560
gene id: 1041930:MTC_RS08560
uniprot id: H8I8Z7
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

1041930:MTC RS04670
gene id: 1041930:MTC_RS04670
uniprot id: H8I4D6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1041930:MTC RS04975
gene id: 1041930:MTC_RS04975
uniprot id: H8I5T6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

1041930:MTC RS04680
gene id: 1041930:MTC_RS04680
uniprot id: H8I4D8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1041930:MTC RS08050
gene id: 1041930:MTC_RS08050
uniprot id: H8I7W6
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS04545
gene id: 1041930:MTC_RS04545
uniprot id: H8I4B0
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1041930:MTC RS00440
gene id: 1041930:MTC_RS00440
uniprot id: H8I5G6
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS02890
gene id: 1041930:MTC_RS02890
uniprot id: H8I5L8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS01620
gene id: 1041930:MTC_RS01620
uniprot id: H8IA26
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1041930:MTC RS01180
gene id: 1041930:MTC_RS01180
uniprot id: H8I8F2
names: Similarity
messages: Belongs to the intimin/invasin family.

1041930:MTC RS11785
gene id: 1041930:MTC_RS11785
uniprot id: H8I4Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1041930:MTC RS04515
gene id: 1041930:MTC_RS04515
uniprot id: H8I4A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1041930:MTC RS01170
gene id: 1041930:MTC_RS01170
uniprot id: H8I8F0
names: Similarity
messages: Belongs to the MtxX family.

1041930:MTC RS06660
gene id: 1041930:MTC_RS06660
uniprot id: H8IAJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1041930:MTC RS01165
gene id: 1041930:MTC_RS01165
uniprot id: H8I8E9
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS03480
gene id: 1041930:MTC_RS03480
uniprot id: H8I8H9
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS08745
gene id: 1041930:MTC_RS08745
uniprot id: H8I9P7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1041930:MTC RS07480
gene id: 1041930:MTC_RS07480
uniprot id: H8I622
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

1041930:MTC RS12405
gene id: 1041930:MTC_RS12405
uniprot id: H8I7K4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS02325
gene id: 1041930:MTC_RS02325
uniprot id: H8I491
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

1041930:MTC RS02125
gene id: 1041930:MTC_RS02125
uniprot id: H8I452
names: Similarity
messages: Belongs to the TOP6A family.

1041930:MTC RS11980
gene id: 1041930:MTC_RS11980
uniprot id: H8I6D3
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS10390
gene id: 1041930:MTC_RS10390
uniprot id: H8I7F4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

1041930:MTC RS07795
gene id: 1041930:MTC_RS07795
uniprot id: H8I765
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

1041930:MTC RS01415
gene id: 1041930:MTC_RS01415
uniprot id: H8I949
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

1041930:MTC RS01065
gene id: 1041930:MTC_RS01065
uniprot id: H8I8C9
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1041930:MTC RS05105
gene id: 1041930:MTC_RS05105
uniprot id: H8I5W1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1041930:MTC RS11195
gene id: 1041930:MTC_RS11195
uniprot id: H8IA17
names: Similarity
messages: Belongs to the TlyA family.

1041930:MTC RS12430
gene id: 1041930:MTC_RS12430
uniprot id: H8I7K9
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS09145
gene id: 1041930:MTC_RS09145
uniprot id: H8IAS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1041930:MTC RS00420
gene id: 1041930:MTC_RS00420
uniprot id: H8I5G2
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS00055
gene id: 1041930:MTC_RS00055
uniprot id: H8I525
names: Similarity
messages: Belongs to the HypD family.

1041930:MTC RS05295
gene id: 1041930:MTC_RS05295
uniprot id: H8I6Y8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

1041930:MTC RS06790
gene id: 1041930:MTC_RS06790
uniprot id: H8IAM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

1041930:MTC RS05275
gene id: 1041930:MTC_RS05275
uniprot id: H8I6Y4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1041930:MTC RS10770
gene id: 1041930:MTC_RS10770
uniprot id: H8I875
names: Similarity
messages: Belongs to the LeuD family. LeuD type 2 subfamily.

1041930:MTC RS09805
gene id: 1041930:MTC_RS09805
uniprot id: H8I662
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1041930:MTC RS07340
gene id: 1041930:MTC_RS07340
uniprot id: H8I5Z2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

1041930:MTC RS00900
gene id: 1041930:MTC_RS00900
uniprot id: H8I896
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

1041930:MTC RS11375
gene id: 1041930:MTC_RS11375
uniprot id: H8IB03
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1041930:MTC RS10745
gene id: 1041930:MTC_RS10745
uniprot id: H8I870
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

1041930:MTC RS09360
gene id: 1041930:MTC_RS09360
uniprot id: H8IAW5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1041930:MTC RS04555
gene id: 1041930:MTC_RS04555
uniprot id: H8I4B2
names: Similarity
messages: Belongs to the UPF0251 family.

1041930:MTC RS11665
gene id: 1041930:MTC_RS11665
uniprot id: H8I4X5
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1041930:MTC RS09675
gene id: 1041930:MTC_RS09675
uniprot id: H8I4U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

1041930:MTC RS11290
gene id: 1041930:MTC_RS11290
uniprot id: H8IAY6
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS04330
gene id: 1041930:MTC_RS04330
uniprot id: H8IAF0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1041930:MTC RS09100
gene id: 1041930:MTC_RS09100
uniprot id: H8IAR3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1041930:MTC RS01140
gene id: 1041930:MTC_RS01140
uniprot id: H8I8E4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1041930:MTC RS09525
gene id: 1041930:MTC_RS09525
uniprot id: H8I4Q9
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

1041930:MTC RS12475
gene id: 1041930:MTC_RS12475
uniprot id: H8I7L7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

1041930:MTC RS02885
gene id: 1041930:MTC_RS02885
uniprot id: H8I5L7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1041930:MTC RS03745
gene id: 1041930:MTC_RS03745
uniprot id: H8I992
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS03625
gene id: 1041930:MTC_RS03625
uniprot id: H8I8K9
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS02875
gene id: 1041930:MTC_RS02875
uniprot id: H8I5L5
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

1041930:MTC RS05025
gene id: 1041930:MTC_RS05025
uniprot id: H8I5U6
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS07680
gene id: 1041930:MTC_RS07680
uniprot id: H8I742
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

1041930:MTC RS06615
gene id: 1041930:MTC_RS06615
uniprot id: H8IAI7
names: Similarity
messages: Belongs to the SUI1 family.

1041930:MTC RS06595
gene id: 1041930:MTC_RS06595
uniprot id: H8IAI3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1041930:MTC RS01840
gene id: 1041930:MTC_RS01840
uniprot id: H8IA70
names: Similarity
messages: Belongs to the peptidase C56 family.

1041930:MTC RS01395
gene id: 1041930:MTC_RS01395
uniprot id: H8I945
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

1041930:MTC RS03660
gene id: 1041930:MTC_RS03660
uniprot id: H8I8L7
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS04540
gene id: 1041930:MTC_RS04540
uniprot id: H8I4A9
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

1041930:MTC RS08620
gene id: 1041930:MTC_RS08620
uniprot id: H8I9M7
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

1041930:MTC RS07570
gene id: 1041930:MTC_RS07570
uniprot id: H8I638
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1041930:MTC RS11915
gene id: 1041930:MTC_RS11915
uniprot id: H8I6C1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1041930:MTC RS02665
gene id: 1041930:MTC_RS02665
uniprot id: H8I597
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1041930:MTC RS03090
gene id: 1041930:MTC_RS03090
uniprot id: H8I6Q5
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS06670
gene id: 1041930:MTC_RS06670
uniprot id: H8IAJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1041930:MTC RS01145
gene id: 1041930:MTC_RS01145
uniprot id: H8I8E5
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1041930:MTC RS00660
gene id: 1041930:MTC_RS00660
uniprot id: H8I6L2
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1041930:MTC RS05695
gene id: 1041930:MTC_RS05695
uniprot id: H8I7R3
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS05280
gene id: 1041930:MTC_RS05280
uniprot id: H8I6Y5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

1041930:MTC RS10045
gene id: 1041930:MTC_RS10045
uniprot id: H8I6A9
names: Similarity
messages: Belongs to the DtxR/MntR family.

1041930:MTC RS02280
gene id: 1041930:MTC_RS02280
uniprot id: H8I483
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

1041930:MTC RS09270
gene id: 1041930:MTC_RS09270
uniprot id: H8IAU5
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

1041930:MTC RS07450
gene id: 1041930:MTC_RS07450
uniprot id: H8I615
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

1041930:MTC RS11775
gene id: 1041930:MTC_RS11775
uniprot id: H8I4Z7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1041930:MTC RS05110
gene id: 1041930:MTC_RS05110
uniprot id: H8I5W2
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

1041930:MTC RS06630
gene id: 1041930:MTC_RS06630
uniprot id: H8IAJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

1041930:MTC RS00695
gene id: 1041930:MTC_RS00695
uniprot id: H8I6L6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

1041930:MTC RS08915
gene id: 1041930:MTC_RS08915
uniprot id: H8I9T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1041930:MTC RS01325
gene id: 1041930:MTC_RS01325
uniprot id: H8I930
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

1041930:MTC RS03210
gene id: 1041930:MTC_RS03210
uniprot id: H8I6S9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

1041930:MTC RS03335
gene id: 1041930:MTC_RS03335
uniprot id: H8I6V6
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

1041930:MTC RS07020
gene id: 1041930:MTC_RS07020
uniprot id: H8I4I5
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1041930:MTC RS00330
gene id: 1041930:MTC_RS00330
uniprot id: H8I5E6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

1041930:MTC RS07560
gene id: 1041930:MTC_RS07560
uniprot id: H8I637
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS03645
gene id: 1041930:MTC_RS03645
uniprot id: H8I8L3
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS01320
gene id: 1041930:MTC_RS01320
uniprot id: H8I929
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1041930:MTC RS01800
gene id: 1041930:MTC_RS01800
uniprot id: H8IA62
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1041930:MTC RS10580
gene id: 1041930:MTC_RS10580
uniprot id: H8I838
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1041930:MTC RS03575
gene id: 1041930:MTC_RS03575
uniprot id: H8I8J7
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS06355
gene id: 1041930:MTC_RS06355
uniprot id: H8I9I7
names: Similarity
messages: Belongs to the ZPR1 family.

1041930:MTC RS07935
gene id: 1041930:MTC_RS07935
uniprot id: H8I793
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

1041930:MTC RS10455
gene id: 1041930:MTC_RS10455
uniprot id: H8I7G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1041930:MTC RS10490
gene id: 1041930:MTC_RS10490
uniprot id: H8I820
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

1041930:MTC RS08645
gene id: 1041930:MTC_RS08645
uniprot id: H8I9N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

1041930:MTC RS07355
gene id: 1041930:MTC_RS07355
uniprot id: H8I5Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1041930:MTC RS04040
gene id: 1041930:MTC_RS04040
uniprot id: H8I9E9
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS07775
gene id: 1041930:MTC_RS07775
uniprot id: H8I761
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1041930:MTC RS00200
gene id: 1041930:MTC_RS00200
uniprot id: H8I5B9
names: Similarity
messages: Belongs to the ComB family.

1041930:MTC RS05000
gene id: 1041930:MTC_RS05000
uniprot id: H8I5U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1041930:MTC RS07555
gene id: 1041930:MTC_RS07555
uniprot id: H8I636
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1041930:MTC RS10835
gene id: 1041930:MTC_RS10835
uniprot id: H8I888
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS04165
gene id: 1041930:MTC_RS04165
uniprot id: H8IAB7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS06880
gene id: 1041930:MTC_RS06880
uniprot id: H8IAN9
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

1041930:MTC RS02785
gene id: 1041930:MTC_RS02785
uniprot id: H8I5J7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1041930:MTC RS03485
gene id: 1041930:MTC_RS03485
uniprot id: H8I8I0
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS04235
gene id: 1041930:MTC_RS04235
uniprot id: H8IAD1
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

1041930:MTC RS04530
gene id: 1041930:MTC_RS04530
uniprot id: H8I4A7
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1041930:MTC RS00285
gene id: 1041930:MTC_RS00285
uniprot id: H8I5D7
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

1041930:MTC RS04990
gene id: 1041930:MTC_RS04990
uniprot id: H8I5T9
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1041930:MTC RS10890
gene id: 1041930:MTC_RS10890
uniprot id: H8I9V8
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

1041930:MTC RS03015
gene id: 1041930:MTC_RS03015
uniprot id: H8I5P3
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

1041930:MTC RS11945
gene id: 1041930:MTC_RS11945
uniprot id: H8I6C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1041930:MTC RS07180
gene id: 1041930:MTC_RS07180
uniprot id: H8I4L6
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1041930:MTC RS09590
gene id: 1041930:MTC_RS09590
uniprot id: H8I4S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

1041930:MTC RS11445
gene id: 1041930:MTC_RS11445
uniprot id: H8IB17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1041930:MTC RS08345
gene id: 1041930:MTC_RS08345
uniprot id: H8I8V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

1041930:MTC RS09310
gene id: 1041930:MTC_RS09310
uniprot id: H8IAV4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

1041930:MTC RS05440
gene id: 1041930:MTC_RS05440
uniprot id: H8I718
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

1041930:MTC RS08475
gene id: 1041930:MTC_RS08475
uniprot id: H8I8Y1
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS01670
gene id: 1041930:MTC_RS01670
uniprot id: H8IA35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

1041930:MTC RS05010
gene id: 1041930:MTC_RS05010
uniprot id: H8I5U3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

1041930:MTC RS00775
gene id: 1041930:MTC_RS00775
uniprot id: H8I6N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1041930:MTC RS07895
gene id: 1041930:MTC_RS07895
uniprot id: H8I785
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS04350
gene id: 1041930:MTC_RS04350
uniprot id: H8IAF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

1041930:MTC RS03855
gene id: 1041930:MTC_RS03855
uniprot id: H8I9B4
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

1041930:MTC RS02365
gene id: 1041930:MTC_RS02365
uniprot id: H8I541
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1041930:MTC RS06000
gene id: 1041930:MTC_RS06000
uniprot id: H8I8Q5
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS11400
gene id: 1041930:MTC_RS11400
uniprot id: H8IB07
names: Similarity
messages: Belongs to the MEMO1 family.

1041930:MTC RS07970
gene id: 1041930:MTC_RS07970
uniprot id: H8I7V1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

1041930:MTC RS12050
gene id: 1041930:MTC_RS12050
uniprot id: H8I6E7
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS06600
gene id: 1041930:MTC_RS06600
uniprot id: H8IAI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1041930:MTC RS11395
gene id: 1041930:MTC_RS11395
uniprot id: H8IB06
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1041930:MTC RS06225
gene id: 1041930:MTC_RS06225
uniprot id: H8I9G1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1041930:MTC RS00925
gene id: 1041930:MTC_RS00925
uniprot id: H8I8A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1041930:MTC RS07865
gene id: 1041930:MTC_RS07865
uniprot id: H8I779
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1041930:MTC RS04400
gene id: 1041930:MTC_RS04400
uniprot id: H8IAG3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1041930:MTC RS12035
gene id: 1041930:MTC_RS12035
uniprot id: H8I6E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

1041930:MTC RS11595
gene id: 1041930:MTC_RS11595
uniprot id: H8I4W1
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS08920
gene id: 1041930:MTC_RS08920
uniprot id: H8I9T2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1041930:MTC RS05485
gene id: 1041930:MTC_RS05485
uniprot id: H8I7M2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1041930:MTC RS04220
gene id: 1041930:MTC_RS04220
uniprot id: H8IAC8
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

1041930:MTC RS03170
gene id: 1041930:MTC_RS03170
uniprot id: H8I6S1
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS04360
gene id: 1041930:MTC_RS04360
uniprot id: H8IAF6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1041930:MTC RS09670
gene id: 1041930:MTC_RS09670
uniprot id: H8I4U0
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

1041930:MTC RS00460
gene id: 1041930:MTC_RS00460
uniprot id: H8I5H0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1041930:MTC RS06415
gene id: 1041930:MTC_RS06415
uniprot id: H8I9J9
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1041930:MTC RS04340
gene id: 1041930:MTC_RS04340
uniprot id: H8IAF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

1041930:MTC RS11645
gene id: 1041930:MTC_RS11645
uniprot id: H8I4X1
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1041930:MTC RS04365
gene id: 1041930:MTC_RS04365
uniprot id: H8IAF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1041930:MTC RS10375
gene id: 1041930:MTC_RS10375
uniprot id: H8I7F1
names: Similarity
messages: Belongs to the UPF0212 family.

1041930:MTC RS02990
gene id: 1041930:MTC_RS02990
uniprot id: H8I5N8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1041930:MTC RS07080
gene id: 1041930:MTC_RS07080
uniprot id: H8I4J7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1041930:MTC RS06705
gene id: 1041930:MTC_RS06705
uniprot id: H8IAK5
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS11030
gene id: 1041930:MTC_RS11030
uniprot id: H8I9Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

1041930:MTC RS04695
gene id: 1041930:MTC_RS04695
uniprot id: H8I4E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1041930:MTC RS06945
gene id: 1041930:MTC_RS06945
uniprot id: H8I4H0
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

1041930:MTC RS11650
gene id: 1041930:MTC_RS11650
uniprot id: H8I4X2
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

1041930:MTC RS11840
gene id: 1041930:MTC_RS11840
uniprot id: H8I511
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS10410
gene id: 1041930:MTC_RS10410
uniprot id: H8I7F8
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

1041930:MTC RS00345
gene id: 1041930:MTC_RS00345
uniprot id: H8I5E8
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

1041930:MTC RS06115
gene id: 1041930:MTC_RS06115
uniprot id: H8I8S9
names: Similarity
messages: Belongs to the UPF0107 family.

1041930:MTC RS00840
gene id: 1041930:MTC_RS00840
uniprot id: H8I6P4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

1041930:MTC RS05175
gene id: 1041930:MTC_RS05175
uniprot id: H8I6W4
names: Similarity
messages: Belongs to the UPF0173 family.

1041930:MTC RS12505
gene id: 1041930:MTC_RS12505
uniprot id: H8I5A9
names: Similarity
messages: In the N-terminal section; belongs to the transposase 2 family.

1041930:MTC RS06715
gene id: 1041930:MTC_RS06715
uniprot id: H8IAK7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1041930:MTC RS00120
gene id: 1041930:MTC_RS00120
uniprot id: H8I5A3
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

1041930:MTC RS10915
gene id: 1041930:MTC_RS10915
uniprot id: H8I9W3
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS07965
gene id: 1041930:MTC_RS07965
uniprot id: H8I7V0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1041930:MTC RS08600
gene id: 1041930:MTC_RS08600
uniprot id: H8I905
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

1041930:MTC RS09815
gene id: 1041930:MTC_RS09815
uniprot id: H8I664
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1041930:MTC RS08735
gene id: 1041930:MTC_RS08735
uniprot id: H8I9P5
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

1041930:MTC RS06960
gene id: 1041930:MTC_RS06960
uniprot id: H8I4H3
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1041930:MTC RS04435
gene id: 1041930:MTC_RS04435
uniprot id: H8IAH0
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS03465
gene id: 1041930:MTC_RS03465
uniprot id: H8I8H6
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

1041930:MTC RS07900
gene id: 1041930:MTC_RS07900
uniprot id: H8I786
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

1041930:MTC RS05645
gene id: 1041930:MTC_RS05645
uniprot id: H8I7Q3
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1041930:MTC RS06610
gene id: 1041930:MTC_RS06610
uniprot id: H8IAI6
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1041930:MTC RS06025
gene id: 1041930:MTC_RS06025
uniprot id: H8I8R1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1041930:MTC RS02645
gene id: 1041930:MTC_RS02645
uniprot id: H8I593
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

1041930:MTC RS02550
gene id: 1041930:MTC_RS02550
uniprot id: H8I578
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

1041930:MTC RS08435
gene id: 1041930:MTC_RS08435
uniprot id: H8I8X3
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

1041930:MTC RS09405
gene id: 1041930:MTC_RS09405
uniprot id: H8I4N4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1041930:MTC RS10595
gene id: 1041930:MTC_RS10595
uniprot id: H8I841
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

1041930:MTC RS10175
gene id: 1041930:MTC_RS10175
uniprot id: H8I7B4
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS05730
gene id: 1041930:MTC_RS05730
uniprot id: H8I7S0
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS05115
gene id: 1041930:MTC_RS05115
uniprot id: H8I5W3
names: Similarity
messages: Belongs to the eIF-2-alpha family.

1041930:MTC RS04685
gene id: 1041930:MTC_RS04685
uniprot id: H8I4D9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1041930:MTC RS10020
gene id: 1041930:MTC_RS10020
uniprot id: H8I6A4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1041930:MTC RS11655
gene id: 1041930:MTC_RS11655
uniprot id: H8I4X3
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

1041930:MTC RS04345
gene id: 1041930:MTC_RS04345
uniprot id: H8IAF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

1041930:MTC RS11950
gene id: 1041930:MTC_RS11950
uniprot id: H8I6C7
names: Similarity
messages: Belongs to the P(II) protein family.

1041930:MTC RS09005
gene id: 1041930:MTC_RS09005
uniprot id: H8I9U7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

1041930:MTC RS07065
gene id: 1041930:MTC_RS07065
uniprot id: H8I4J4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1041930:MTC RS05790
gene id: 1041930:MTC_RS05790
uniprot id: H8I7T2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

1041930:MTC RS02160
gene id: 1041930:MTC_RS02160
uniprot id: H8I459
names: Similarity
messages: Belongs to the UPF0147 family.

1041930:MTC RS09795
gene id: 1041930:MTC_RS09795
uniprot id: H8I660
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1041930:MTC RS02230
gene id: 1041930:MTC_RS02230
uniprot id: H8I473
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS08935
gene id: 1041930:MTC_RS08935
uniprot id: H8I9T5
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

1041930:MTC RS06290
gene id: 1041930:MTC_RS06290
uniprot id: H8I9H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

1041930:MTC RS07325
gene id: 1041930:MTC_RS07325
uniprot id: H8I5Y9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

1041930:MTC RS00310
gene id: 1041930:MTC_RS00310
uniprot id: H8I5E2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

1041930:MTC RS05585
gene id: 1041930:MTC_RS05585
uniprot id: H8I7P0
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS05240
gene id: 1041930:MTC_RS05240
uniprot id: H8I6X7
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

1041930:MTC RS11360
gene id: 1041930:MTC_RS11360
uniprot id: H8IB00
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

1041930:MTC RS00215
gene id: 1041930:MTC_RS00215
uniprot id: H8I5C2
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

1041930:MTC RS09070
gene id: 1041930:MTC_RS09070
uniprot id: H8IAQ7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

1041930:MTC RS08690
gene id: 1041930:MTC_RS08690
uniprot id: H8I9P1
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

1041930:MTC RS06965
gene id: 1041930:MTC_RS06965
uniprot id: H8I4H4
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1041930:MTC RS07660
gene id: 1041930:MTC_RS07660
uniprot id: H8I738
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS02180
gene id: 1041930:MTC_RS02180
uniprot id: H8I463
names: Similarity
messages: Belongs to the PDCD5 family.

1041930:MTC RS06690
gene id: 1041930:MTC_RS06690
uniprot id: H8IAK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1041930:MTC RS11970
gene id: 1041930:MTC_RS11970
uniprot id: H8I6D1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS01390
gene id: 1041930:MTC_RS01390
uniprot id: H8I943
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1041930:MTC RS02215
gene id: 1041930:MTC_RS02215
uniprot id: H8I470
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1041930:MTC RS11225
gene id: 1041930:MTC_RS11225
uniprot id: H8IAX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

1041930:MTC RS10735
gene id: 1041930:MTC_RS10735
uniprot id: H8I868
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

1041930:MTC RS08500
gene id: 1041930:MTC_RS08500
uniprot id: H8I8Y7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1041930:MTC RS08195
gene id: 1041930:MTC_RS08195
uniprot id: H8I7Z7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1041930:MTC RS08240
gene id: 1041930:MTC_RS08240
uniprot id: H8I805
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1041930:MTC RS00675
gene id: 1041930:MTC_RS00675
uniprot id: H8I6L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

1041930:MTC RS11170
gene id: 1041930:MTC_RS11170
uniprot id: H8IA12
names: Subcellular Location Annotation
messages: Cytoplasm

1041930:MTC RS00060
gene id: 1041930:MTC_RS00060
uniprot id: H8I526
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1041930:MTC RS11255
gene id: 1041930:MTC_RS11255
uniprot id: H8IAY0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1041930:MTC RS06625
gene id: 1041930:MTC_RS06625
uniprot id: H8IAI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1041930:MTC RS11220
gene id: 1041930:MTC_RS11220
uniprot id: H8IAX3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

1041930:MTC RS01085
gene id: 1041930:MTC_RS01085
uniprot id: H8I8D3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1041930:MTC RS03285
gene id: 1041930:MTC_RS03285
uniprot id: H8I6U6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1041930:MTC RS03265
gene id: 1041930:MTC_RS03265
uniprot id: H8I6U1
names: Function
messages: Involved in the transposition of the insertion sequence IS5.

1041930:MTC RS01510
gene id: 1041930:MTC_RS01510
uniprot id: H8I967
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

1041930:MTC RS04850
gene id: 1041930:MTC_RS04850
uniprot id: H8I5R2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

1041930:MTC RS09995
gene id: 1041930:MTC_RS09995
uniprot id: H8I699
names: Similarity
messages: Belongs to the peptidase S8 family.

1041930:MTC RS09215
gene id: 1041930:MTC_RS09215
uniprot id: H8IAT4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1041930:MTC RS01070
gene id: 1041930:MTC_RS01070
uniprot id: H8I8D0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1041930:MTC RS09340
gene id: 1041930:MTC_RS09340
uniprot id: H8IAW1
names: Similarity
messages: Belongs to the UPF0179 family.

1041930:MTC RS11020
gene id: 1041930:MTC_RS11020
uniprot id: H8I9Y4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1041930:MTC RS00170
gene id: 1041930:MTC_RS00170
uniprot id: H8I5B3
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS07135
gene id: 1041930:MTC_RS07135
uniprot id: H8I4L5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1041930:MTC RS00210
gene id: 1041930:MTC_RS00210
uniprot id: H8I5C1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS12075
gene id: 1041930:MTC_RS12075
uniprot id: H8I6F1
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS08975
gene id: 1041930:MTC_RS08975
uniprot id: H8I9U1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

1041930:MTC RS02200
gene id: 1041930:MTC_RS02200
uniprot id: H8I467
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

1041930:MTC RS07015
gene id: 1041930:MTC_RS07015
uniprot id: H8I4I4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1041930:MTC RS01595
gene id: 1041930:MTC_RS01595
uniprot id: H8IA22
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1041930:MTC RS11610
gene id: 1041930:MTC_RS11610
uniprot id: H8I4W4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1041930:MTC RS04075
gene id: 1041930:MTC_RS04075
uniprot id: H8IAA0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1041930:MTC RS00780
gene id: 1041930:MTC_RS00780
uniprot id: H8I6N1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1041930:MTC RS02560
gene id: 1041930:MTC_RS02560
uniprot id: H8I580
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS12320
gene id: 1041930:MTC_RS12320
uniprot id: H8I7I5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

1041930:MTC RS02080
gene id: 1041930:MTC_RS02080
uniprot id: H8I443
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

1041930:MTC RS08770
gene id: 1041930:MTC_RS08770
uniprot id: H8I9Q2
names: Similarity
messages: Belongs to the AAA ATPase family.

1041930:MTC RS05975
gene id: 1041930:MTC_RS05975
uniprot id: H8I8Q0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

1041930:MTC RS00270
gene id: 1041930:MTC_RS00270
uniprot id: H8I5D4
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS09660
gene id: 1041930:MTC_RS09660
uniprot id: H8I4T8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

1041930:MTC RS10725
gene id: 1041930:MTC_RS10725
uniprot id: H8I866
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1041930:MTC RS10765
gene id: 1041930:MTC_RS10765
uniprot id: H8I874
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1041930:MTC RS06780
gene id: 1041930:MTC_RS06780
uniprot id: H8IAL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

1041930:MTC RS04985
gene id: 1041930:MTC_RS04985
uniprot id: H8I5T8
names: Similarity
messages: Belongs to the FrhG family.

1041930:MTC RS05880
gene id: 1041930:MTC_RS05880
uniprot id: H8I8N2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1041930:MTC RS11015
gene id: 1041930:MTC_RS11015
uniprot id: H8I9Y3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1041930:MTC RS07810
gene id: 1041930:MTC_RS07810
uniprot id: H8I768
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

1041930:MTC RS04035
gene id: 1041930:MTC_RS04035
uniprot id: H8I9E8
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS04105
gene id: 1041930:MTC_RS04105
uniprot id: H8IAA5
names: Similarity
messages: Belongs to the HupF/HypC family.

1041930:MTC RS06590
gene id: 1041930:MTC_RS06590
uniprot id: H8IAI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1041930:MTC RS05505
gene id: 1041930:MTC_RS05505
uniprot id: H8I7M5
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS07640
gene id: 1041930:MTC_RS07640
uniprot id: H8I735
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1041930:MTC RS05610
gene id: 1041930:MTC_RS05610
uniprot id: H8I7P6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

1041930:MTC RS01900
gene id: 1041930:MTC_RS01900
uniprot id: H8IA82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1041930:MTC RS01385
gene id: 1041930:MTC_RS01385
uniprot id: H8I942
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1041930:MTC RS00455
gene id: 1041930:MTC_RS00455
uniprot id: H8I5G9
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1041930:MTC RS04100
gene id: 1041930:MTC_RS04100
uniprot id: H8IAA4
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

1041930:MTC RS09120
gene id: 1041930:MTC_RS09120
uniprot id: H8IAR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

1041930:MTC RS06605
gene id: 1041930:MTC_RS06605
uniprot id: H8IAI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

1041930:MTC RS06710
gene id: 1041930:MTC_RS06710
uniprot id: H8IAK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

1041930:MTC RS01755
gene id: 1041930:MTC_RS01755
uniprot id: H8IA53
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

1041930:MTC RS04715
gene id: 1041930:MTC_RS04715
uniprot id: H8I4E5
names: Function
messages: Part of a potassium transport system.

1041930:MTC RS10330
gene id: 1041930:MTC_RS10330
uniprot id: H8I7E4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

1041930:MTC RS00035
gene id: 1041930:MTC_RS00035
uniprot id: H8I523
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1041930:MTC RS00525
gene id: 1041930:MTC_RS00525
uniprot id: H8I6I5
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

1041930:MTC RS12385
gene id: 1041930:MTC_RS12385
uniprot id: H8I7K0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1041930:MTC RS06755
gene id: 1041930:MTC_RS06755
uniprot id: H8IAL4
names: Similarity
messages: Belongs to the DMRL synthase family.

1041930:MTC RS11560
gene id: 1041930:MTC_RS11560
uniprot id: H8I4V2
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

1041930:MTC RS07485
gene id: 1041930:MTC_RS07485
uniprot id: H8I623
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

1041930:MTC RS02355
gene id: 1041930:MTC_RS02355
uniprot id: H8I539
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1041930:MTC RS00760
gene id: 1041930:MTC_RS00760
uniprot id: H8I6M7
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

1041930:MTC RS04800
gene id: 1041930:MTC_RS04800
uniprot id: H8I5Q3
names: Subcellular Location Annotation
messages: Cytoplasm

1041930:MTC RS10210
gene id: 1041930:MTC_RS10210
uniprot id: H8I7C1
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS06080
gene id: 1041930:MTC_RS06080
uniprot id: H8I8S2
names: Similarity
messages: Belongs to the AOR/FOR family.

1041930:MTC RS11690
gene id: 1041930:MTC_RS11690
uniprot id: H8I4Y0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

1041930:MTC RS10530
gene id: 1041930:MTC_RS10530
uniprot id: H8I828
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1041930:MTC RS03715
gene id: 1041930:MTC_RS03715
uniprot id: H8I986
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1041930:MTC RS10625
gene id: 1041930:MTC_RS10625
uniprot id: H8I847
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1041930:MTC RS11010
gene id: 1041930:MTC_RS11010
uniprot id: H8I9Y2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1041930:MTC RS03360
gene id: 1041930:MTC_RS03360
uniprot id: H8I6W1
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS06490
gene id: 1041930:MTC_RS06490
uniprot id: H8I9L5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS12125
gene id: 1041930:MTC_RS12125
uniprot id: H8I6G1
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS00015
gene id: 1041930:MTC_RS00015
uniprot id: H8I519
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS06525
gene id: 1041930:MTC_RS06525
uniprot id: H8I9M2
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS00905
gene id: 1041930:MTC_RS00905
uniprot id: H8I897
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

1041930:MTC RS03960
gene id: 1041930:MTC_RS03960
uniprot id: H8I9D3
names: Similarity
messages: Belongs to the UPF0200 family.
messages: Belongs to the UPF0201 family.

1041930:MTC RS09355
gene id: 1041930:MTC_RS09355
uniprot id: H8IAW4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1041930:MTC RS05560
gene id: 1041930:MTC_RS05560
uniprot id: H8I7N5
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS06580
gene id: 1041930:MTC_RS06580
uniprot id: H8IAI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1041930:MTC RS10030
gene id: 1041930:MTC_RS10030
uniprot id: H8I6A6
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

1041930:MTC RS04505
gene id: 1041930:MTC_RS04505
uniprot id: H8I4A2
names: Similarity
messages: Belongs to the class-I fumarase family.

1041930:MTC RS12335
gene id: 1041930:MTC_RS12335
uniprot id: H8I7I8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

1041930:MTC RS09555
gene id: 1041930:MTC_RS09555
uniprot id: H8I4R6
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

1041930:MTC RS11305
gene id: 1041930:MTC_RS11305
uniprot id: H8IAY9
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

1041930:MTC RS08155
gene id: 1041930:MTC_RS08155
uniprot id: H8I7Y9
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS04645
gene id: 1041930:MTC_RS04645
uniprot id: H8I4C9
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

1041930:MTC RS08395
gene id: 1041930:MTC_RS08395
uniprot id: H8I8W4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1041930:MTC RS05265
gene id: 1041930:MTC_RS05265
uniprot id: H8I6Y2
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

1041930:MTC RS04325
gene id: 1041930:MTC_RS04325
uniprot id: H8IAE9
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

1041930:MTC RS01895
gene id: 1041930:MTC_RS01895
uniprot id: H8IA81
names: Similarity
messages: Belongs to the TrpF family.

1041930:MTC RS05870
gene id: 1041930:MTC_RS05870
uniprot id: H8I8N0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1041930:MTC RS12040
gene id: 1041930:MTC_RS12040
uniprot id: H8I6E5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1041930:MTC RS02925
gene id: 1041930:MTC_RS02925
uniprot id: H8I5M4
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

1041930:MTC RS10935
gene id: 1041930:MTC_RS10935
uniprot id: H8I9W6
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS10575
gene id: 1041930:MTC_RS10575
uniprot id: H8I837
names: Similarity
messages: Belongs to the peptidase C1 family.

1041930:MTC RS08390
gene id: 1041930:MTC_RS08390
uniprot id: H8I8W3
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS06215
gene id: 1041930:MTC_RS06215
uniprot id: H8I9F9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1041930:MTC RS09205
gene id: 1041930:MTC_RS09205
uniprot id: H8IAT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1041930:MTC RS05005
gene id: 1041930:MTC_RS05005
uniprot id: H8I5U2
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1041930:MTC RS09040
gene id: 1041930:MTC_RS09040
uniprot id: H8IAQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1041930:MTC RS01240
gene id: 1041930:MTC_RS01240
uniprot id: H8I913
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS07625
gene id: 1041930:MTC_RS07625
uniprot id: H8I732
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1041930:MTC RS00990
gene id: 1041930:MTC_RS00990
uniprot id: H8I8B4
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS06765
gene id: 1041930:MTC_RS06765
uniprot id: H8IAL6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1041930:MTC RS03225
gene id: 1041930:MTC_RS03225
uniprot id: H8I6T2
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

1041930:MTC RS08140
gene id: 1041930:MTC_RS08140
uniprot id: H8I7Y6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS07635
gene id: 1041930:MTC_RS07635
uniprot id: H8I734
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1041930:MTC RS11620
gene id: 1041930:MTC_RS11620
uniprot id: H8I4W6
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

1041930:MTC RS06685
gene id: 1041930:MTC_RS06685
uniprot id: H8IAK1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1041930:MTC RS02640
gene id: 1041930:MTC_RS02640
uniprot id: H8I592
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

1041930:MTC RS04780
gene id: 1041930:MTC_RS04780
uniprot id: H8I4F9
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

1041930:MTC RS05760
gene id: 1041930:MTC_RS05760
uniprot id: H8I7S6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1041930:MTC RS10755
gene id: 1041930:MTC_RS10755
uniprot id: H8I872
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1041930:MTC RS09325
gene id: 1041930:MTC_RS09325
uniprot id: H8IAV8
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1041930:MTC RS02850
gene id: 1041930:MTC_RS02850
uniprot id: H8I5L0
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS11860
gene id: 1041930:MTC_RS11860
uniprot id: H8I515
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1041930:MTC RS09320
gene id: 1041930:MTC_RS09320
uniprot id: H8IAV7
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS02205
gene id: 1041930:MTC_RS02205
uniprot id: H8I468
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

1041930:MTC RS11480
gene id: 1041930:MTC_RS11480
uniprot id: H8IB23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1041930:MTC RS00810
gene id: 1041930:MTC_RS00810
uniprot id: H8I6N7
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1041930:MTC RS00845
gene id: 1041930:MTC_RS00845
uniprot id: H8I6P5
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1041930:MTC RS11370
gene id: 1041930:MTC_RS11370
uniprot id: H8IB02
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1041930:MTC RS10970
gene id: 1041930:MTC_RS10970
uniprot id: H8I9X3
names: Similarity
messages: Belongs to the SUI1 family.

1041930:MTC RS02190
gene id: 1041930:MTC_RS02190
uniprot id: H8I465
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

1041930:MTC RS10605
gene id: 1041930:MTC_RS10605
uniprot id: H8I843
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

1041930:MTC RS02650
gene id: 1041930:MTC_RS02650
uniprot id: H8I594
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1041930:MTC RS12445
gene id: 1041930:MTC_RS12445
uniprot id: H8I7L2
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1041930:MTC RS01875
gene id: 1041930:MTC_RS01875
uniprot id: H8IA77
names: Similarity
messages: Belongs to the TrpC family.

1041930:MTC RS11215
gene id: 1041930:MTC_RS11215
uniprot id: H8IAX2
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

1041930:MTC RS02350
gene id: 1041930:MTC_RS02350
uniprot id: H8I538
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

1041930:MTC RS02465
gene id: 1041930:MTC_RS02465
uniprot id: H8I561
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1041930:MTC RS07960
gene id: 1041930:MTC_RS07960
uniprot id: H8I7U9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1041930:MTC RS08100
gene id: 1041930:MTC_RS08100
uniprot id: H8I7X7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1041930:MTC RS11365
gene id: 1041930:MTC_RS11365
uniprot id: H8IB01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1041930:MTC RS12290
gene id: 1041930:MTC_RS12290
uniprot id: H8I7I0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

1041930:MTC RS11465
gene id: 1041930:MTC_RS11465
uniprot id: H8IB21
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS04625
gene id: 1041930:MTC_RS04625
uniprot id: H8I4C5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1041930:MTC RS02865
gene id: 1041930:MTC_RS02865
uniprot id: H8I5L3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1041930:MTC RS00670
gene id: 1041930:MTC_RS00670
uniprot id: H8I6L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1041930:MTC RS06345
gene id: 1041930:MTC_RS06345
uniprot id: H8I9I5
names: Similarity
messages: Belongs to the RuvC family.

1041930:MTC RS06035
gene id: 1041930:MTC_RS06035
uniprot id: H8I8R3
names: Similarity
messages: Belongs to the UPF0305 family.

1041930:MTC RS10880
gene id: 1041930:MTC_RS10880
uniprot id: H8I9V6
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

1041930:MTC RS00325
gene id: 1041930:MTC_RS00325
uniprot id: H8I5E5
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

1041930:MTC RS08115
gene id: 1041930:MTC_RS08115
uniprot id: H8I7Y0
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1041930:MTC RS11990
gene id: 1041930:MTC_RS11990
uniprot id: H8I6D5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1041930:MTC RS11580
gene id: 1041930:MTC_RS11580
uniprot id: H8I4V8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1041930:MTC RS04095
gene id: 1041930:MTC_RS04095
uniprot id: H8IAA3
names: Similarity
messages: Belongs to the HypE family.

1041930:MTC RS01685
gene id: 1041930:MTC_RS01685
uniprot id: H8IA38
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS01565
gene id: 1041930:MTC_RS01565
uniprot id: H8I979
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS09950
gene id: 1041930:MTC_RS09950
uniprot id: H8I690
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS08000
gene id: 1041930:MTC_RS08000
uniprot id: H8I7V6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS01530
gene id: 1041930:MTC_RS01530
uniprot id: H8I971
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1041930:MTC RS10710
gene id: 1041930:MTC_RS10710
uniprot id: H8I863
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1041930:MTC RS05710
gene id: 1041930:MTC_RS05710
uniprot id: H8I7R6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1041930:MTC RS12400
gene id: 1041930:MTC_RS12400
uniprot id: H8I7K3
names: Subcellular Location Annotation
messages: Cell membrane

1041930:MTC RS03190
gene id: 1041930:MTC_RS03190
uniprot id: H8I6S5
names: Similarity
messages: Belongs to the UPF0175 family.

1041930:MTC RS03220
gene id: 1041930:MTC_RS03220
uniprot id: H8I6T1
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1041930:MTC RS00125
gene id: 1041930:MTC_RS00125
uniprot id: H8I5A4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

1041930:MTC RS09850
gene id: 1041930:MTC_RS09850
uniprot id: H8I671
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

1041930:MTC RS01080
gene id: 1041930:MTC_RS01080
uniprot id: H8I8D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1041930:MTC RS11295
gene id: 1041930:MTC_RS11295
uniprot id: H8IAY7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1041930:MTC RS10920
gene id: 1041930:MTC_RS10920
uniprot id: H8I9W4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

1041930:MTC RS00550
gene id: 1041930:MTC_RS00550
uniprot id: H8I6J0
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1041930:MTC RS09250
gene id: 1041930:MTC_RS09250
uniprot id: H8IAU1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1041930:MTC RS04770
gene id: 1041930:MTC_RS04770
uniprot id: H8I4F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1041930:MTC RS06985
gene id: 1041930:MTC_RS06985
uniprot id: H8I4H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

1041930:MTC RS07175
gene id: 1041930:MTC_RS07175
uniprot id: H8I4L5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1041930:MTC RS12175
gene id: 1041930:MTC_RS12175
uniprot id: H8I6H1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1041930:MTC RS03010
gene id: 1041930:MTC_RS03010
uniprot id: H8I5P2
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

1041930:MTC RS04355
gene id: 1041930:MTC_RS04355
uniprot id: H8IAF5
names: Similarity
messages: Belongs to the SDO1/SBDS family.

1041930:MTC RS03250
gene id: 1041930:MTC_RS03250
uniprot id: H8I6T7
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

1041930:MTC RS04335
gene id: 1041930:MTC_RS04335
uniprot id: H8IAF1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1041930:MTC RS10775
gene id: 1041930:MTC_RS10775
uniprot id: H8I876
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1041930:MTC RS06385
gene id: 1041930:MTC_RS06385
uniprot id: H8I9J4
names: Similarity
messages: Belongs to the UPF0285 family.

1041930:MTC RS02855
gene id: 1041930:MTC_RS02855
uniprot id: H8I5L1
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS09200
gene id: 1041930:MTC_RS09200
uniprot id: H8IAT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1041930:MTC RS03695
gene id: 1041930:MTC_RS03695
uniprot id: H8I8M4
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS12345
gene id: 1041930:MTC_RS12345
uniprot id: H8I7J0
names: Similarity
messages: Belongs to the HdrC family.

1041930:MTC RS09150
gene id: 1041930:MTC_RS09150
uniprot id: H8IAS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1041930:MTC RS05080
gene id: 1041930:MTC_RS05080
uniprot id: H8I5V6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1041930:MTC RS04160
gene id: 1041930:MTC_RS04160
uniprot id: H8IAB6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1041930:MTC RS12200
gene id: 1041930:MTC_RS12200
uniprot id: H8I6H7
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

1041930:MTC RS02335
gene id: 1041930:MTC_RS02335
uniprot id: H8I535
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1041930:MTC RS03205
gene id: 1041930:MTC_RS03205
uniprot id: H8I6S8
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1041930:MTC RS05630
gene id: 1041930:MTC_RS05630
uniprot id: H8I7Q0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

1041930:MTC RS06940
gene id: 1041930:MTC_RS06940
uniprot id: H8I4G9
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1041930:MTC RS11760
gene id: 1041930:MTC_RS11760
uniprot id: H8I4Z4
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

1041930:MTC RS07415
gene id: 1041930:MTC_RS07415
uniprot id: H8I607
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

1041930:MTC RS06975
gene id: 1041930:MTC_RS06975
uniprot id: H8I4H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

1041930:MTC RS07000
gene id: 1041930:MTC_RS07000
uniprot id: H8I4I1
names: Similarity
messages: Belongs to the UPF0047 family.

1041930:MTC RS06680
gene id: 1041930:MTC_RS06680
uniprot id: H8IAK0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1041930:MTC RS03775
gene id: 1041930:MTC_RS03775
uniprot id: H8I998
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1041930:MTC RS10335
gene id: 1041930:MTC_RS10335
uniprot id: H8I7E5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

1041930:MTC RS00890
gene id: 1041930:MTC_RS00890
uniprot id: H8I894
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

1041930:MTC RS02275
gene id: 1041930:MTC_RS02275
uniprot id: H8I482
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

1041930:MTC RS06315
gene id: 1041930:MTC_RS06315
uniprot id: H8I9H9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

1041930:MTC RS10240
gene id: 1041930:MTC_RS10240
uniprot id: H8I7C7
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

1041930:MTC RS10825
gene id: 1041930:MTC_RS10825
uniprot id: H8I886
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

1041930:MTC RS11675
gene id: 1041930:MTC_RS11675
uniprot id: H8I4X7
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS06585
gene id: 1041930:MTC_RS06585
uniprot id: H8IAI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

1041930:MTC RS07310
gene id: 1041930:MTC_RS07310
uniprot id: H8I5Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the threonine synthase family. Cysteate synthase subfamily.
messages: Homotrimer.
messages: Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate.

1041930:MTC RS06235
gene id: 1041930:MTC_RS06235
uniprot id: H8I9G3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS05300
gene id: 1041930:MTC_RS05300
uniprot id: H8I6Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

1041930:MTC RS00855
gene id: 1041930:MTC_RS00855
uniprot id: H8I6P8
names: Similarity
messages: Belongs to the archaeal-type GPI family.

1041930:MTC RS06620
gene id: 1041930:MTC_RS06620
uniprot id: H8IAI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1041930:MTC RS05395
gene id: 1041930:MTC_RS05395
uniprot id: H8I708
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1041930:MTC RS06110
gene id: 1041930:MTC_RS06110
uniprot id: H8I8S8
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS09425
gene id: 1041930:MTC_RS09425
uniprot id: H8I4N8
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: The active site is a redox-active disulfide bond.

1041930:MTC RS05705
gene id: 1041930:MTC_RS05705
uniprot id: H8I7R5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1041930:MTC RS03875
gene id: 1041930:MTC_RS03875
uniprot id: H8I9B7
names: Similarity
messages: Belongs to the CutA family.

1041930:MTC RS12160
gene id: 1041930:MTC_RS12160
uniprot id: H8I6G8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

1041930:MTC RS06725
gene id: 1041930:MTC_RS06725
uniprot id: H8IAK8
names: Similarity
messages: Belongs to the UPF0111 family.

1041930:MTC RS05285
gene id: 1041930:MTC_RS05285
uniprot id: H8I6Y6
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

1041930:MTC RS08830
gene id: 1041930:MTC_RS08830
uniprot id: H8I9R4
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS08505
gene id: 1041930:MTC_RS08505
uniprot id: H8I8Y8
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS06970
gene id: 1041930:MTC_RS06970
uniprot id: H8I4H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

1041930:MTC RS08590
gene id: 1041930:MTC_RS08590
uniprot id: H8I903
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS10145
gene id: 1041930:MTC_RS10145
uniprot id: H8I7A9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

1041930:MTC RS04945
gene id: 1041930:MTC_RS04945
uniprot id: H8I5T0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1041930:MTC RS09420
gene id: 1041930:MTC_RS09420
uniprot id: H8I4N7
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1041930:MTC RS11550
gene id: 1041930:MTC_RS11550
uniprot id: H8I4V0
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1041930:MTC RS08225
gene id: 1041930:MTC_RS08225
uniprot id: H8I803
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1041930:MTC RS01305
gene id: 1041930:MTC_RS01305
uniprot id: H8I926
names: Caution
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS11260
gene id: 1041930:MTC_RS11260
uniprot id: H8IAY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

1041930:MTC RS10520
gene id: 1041930:MTC_RS10520
uniprot id: H8I826
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1041930:MTC RS07870
gene id: 1041930:MTC_RS07870
uniprot id: H8I780
names: Subcellular Location Annotation
messages: Membrane

1041930:MTC RS11670
gene id: 1041930:MTC_RS11670
uniprot id: H8I4X6
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1041930:MTC RS03935
gene id: 1041930:MTC_RS03935
uniprot id: H8I9C8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1041930:MTC RS10395
gene id: 1041930:MTC_RS10395
uniprot id: H8I7F5
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

1041930:MTC RS09750
gene id: 1041930:MTC_RS09750
uniprot id: H8I651
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

1041930:MTC RS02300
gene id: 1041930:MTC_RS02300
uniprot id: H8I486
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

1041930:MTC RS09680
gene id: 1041930:MTC_RS09680
uniprot id: H8I4U2
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

1041930:MTC RS04650
gene id: 1041930:MTC_RS04650
uniprot id: H8I4D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1041930:MTC RS10740
gene id: 1041930:MTC_RS10740
uniprot id: H8I869
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

1041930:MTC RS12440
gene id: 1041930:MTC_RS12440
uniprot id: H8I7L1
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS10730
gene id: 1041930:MTC_RS10730
uniprot id: H8I867
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

1041930:MTC RS04315
gene id: 1041930:MTC_RS04315
uniprot id: H8IAE7
names: Similarity
messages: Belongs to the UPF0440 family.

1041930:MTC RS04665
gene id: 1041930:MTC_RS04665
uniprot id: H8I4D5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1041930:MTC RS11420
gene id: 1041930:MTC_RS11420
uniprot id: H8IB11
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

1041930:MTC RS10055
gene id: 1041930:MTC_RS10055
uniprot id: H8I6B1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1041930:MTC RS11975
gene id: 1041930:MTC_RS11975
uniprot id: H8I6D2
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

1041930:MTC RS06275
gene id: 1041930:MTC_RS06275
uniprot id: H8I9H1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1041930:MTC RS07780
gene id: 1041930:MTC_RS07780
uniprot id: H8I762
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

1041930:MTC RS02835
gene id: 1041930:MTC_RS02835
uniprot id: H8I5K7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1041930:MTC RS08190
gene id: 1041930:MTC_RS08190
uniprot id: H8I7Z6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1041930:MTC RS05415
gene id: 1041930:MTC_RS05415
uniprot id: H8I712
names: Similarity
messages: Belongs to the UPF0215 family.

1041930:MTC RS04740
gene id: 1041930:MTC_RS04740
uniprot id: H8I4F0
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1041930:MTC RS03460
gene id: 1041930:MTC_RS03460
uniprot id: H8I8H5
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1041930:MTC RS12130
gene id: 1041930:MTC_RS12130
uniprot id: H8I6G2
names: Cofactor
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.
messages: Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues.