10116:Hrob
gene id: 10116:Hrob
uniprot id: Q6GX86
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: By E2F1 and serum stimulation.
messages: Chromosome
messages: DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis.
messages: Interacts with MCM8; this interaction is necessary for MCM8-MCM9 helicase complex recruitment to DNA damage sites (By similarity). Interacts with RPA1; this interaction associates HROB with the RPA complex (By similarity).
messages: Nucleus

10116:Nt5dc3
gene id: 10116:Nt5dc3
uniprot id: D3ZAI6
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

10116:Slc9a2
gene id: 10116:Slc9a2
uniprot id: A6INP3
uniprot id: A6INP4
uniprot id: P48763
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Interacts with CHP1 and CHP2.
messages: Li(+) activates Na(+)/H(+) exchanger.
messages: Membrane
messages: Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:10678742, PubMed:8244988, PubMed:8244989). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic crypt intracellular pH (pHi) to direct colonic epithelial cell differentiation into the absorptive enterocyte lineage at the expense of the secretory lineage (By similarity).
messages: Predominantly in small intestine, colon, and stomach, with much lower levels in skeletal muscle, kidney, brain, testis, uterus, heart and lung.
messages: PubMed:8595899 sequence was originally thought to originate from human.
messages: The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among authors.

10116:Hoxc10
gene id: 10116:Hoxc10
uniprot id: A6KCY6
uniprot id: G3V815
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

10116:Zdhhc17
gene id: 10116:Zdhhc17
uniprot id: E9PTT0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport.
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Interacts (via ANK repeats) with numerous proteins (via the consensus sequence motif [VIAP]-[VIT]-x-x-Q-P). Interacts (via ANK repeats) with CLIP3. Interacts (via ANK repeats) with HTT (By similarity). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (PubMed:25253725). Interacts (via ANK repeats) with MAP6. Interacts (via ANK repeats) with SNAP23 (By similarity). Interacts (via ANK repeats) with SNAP25(PubMed:25253725, PubMed:26198635). Interacts (via ANK repeats) with EVL (By similarity). Interacts with SPRED1 and SPRED3 (By similarity). Interacts with GPM6A and OPTN (By similarity). May interact (via ANK repeats) with SPRED2 (By similarity). May interact with NTRK1; may regulate its localization and function (By similarity).
messages: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (By similarity). Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3 (By similarity). Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade (By similarity). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (By similarity). May play a role in Mg(2+) transport (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Palmitoylates CASP6, thereby preventing its dimerization and subsequent activation (By similarity).
messages: Presynaptic cell membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

10116:Nup35
gene id: 10116:Nup35
uniprot id: Q68FY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC (By similarity).
messages: Interacts with TMEM48/NDC1 (By similarity). Forms a complex with NUP93, NUP155, NUP205 and lamin B. The interaction with NUP93 is direct (By similarity).
messages: Nucleus membrane
messages: nuclear pore complex

10116:Pbld1
gene id: 10116:Pbld1
uniprot id: Q68G31
names: Similarity
names: Subunit
messages: Belongs to the PhzF family.
messages: Interacts with UNRIP/MAWD.

10116:Xpo1
gene id: 10116:Xpo1
uniprot id: A6JQ67
uniprot id: Q80U96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the exportin family.
messages: Cajal body
messages: Cytoplasm
messages: Found in a U snRNA export complex with PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA. Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUP42, NUP88, NUP214, RANBP3 and TERT. Interacts with NEMF (via its N-terminus). Interacts with the monomeric form of BIRC5/survivin deacetylated at 'Lys-129'. Interacts with DTNBP1 and SERTAD2; the interactions translocate DTNBP1 and SERTAD2 out of the nucleus. Interacts with ATF2. Interacts with SLC35G1 and STIM1. Interacts with DCAF8. Interacts with CPEB3. Interacts with HAX1. Interacts with BOK; translocates to the cytoplasm (By similarity). Interacts with HSP90AB1 (By similarity). Interacts with LRPPRC; interacts with LRPPRC alone and also when LRPPRC is in complex with EIF4E and with EIF4E sensitivity element (4ESE)-containing mRNAs to form an EIF4E-dependent mRNA export complex (By similarity).
messages: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap (By similarity).
messages: nucleolus
messages: nucleoplasm

10116:Hoxa1
gene id: 10116:Hoxa1
uniprot id: A6K0P9
uniprot id: G3V6R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

10116:Pon2
gene id: 10116:Pon2
uniprot id: Q6AXM8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters.
messages: Glycosylated.
messages: Homotrimer.
messages: Membrane
messages: The signal sequence is not cleaved.

10116:Olr1095
gene id: 10116:Olr1095
uniprot id: M0RB21
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Abcc12
gene id: 10116:Abcc12
uniprot id: Q6Y306
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Does not transport any of the organic anions transported by the other multidrug resistance-associated proteins (MRPs) in vesicular transport assays, nor does it confer resistance to cytotoxic agents in intact cell assays.
messages: Endoplasmic reticulum membrane
messages: High expressed in testis.
messages: Probable transporter, its substrate specificity is unknown.

10116:Trnau1ap
gene id: 10116:Trnau1ap
uniprot id: Q9QZI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RRM TRSPAP family.
messages: Component of the tRNA(Sec) complex composed at least of EEFSEC, SECISBP2, SEPHS1, SEPSECS, TRNAU1AP and tRNA(Sec). Associates with mRNP and/or polysomes (By similarity). Found in a complex with tRNA(Sec). Interacts with SEPSECS.
messages: Cytoplasm
messages: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity).
messages: Nucleus
messages: Ubiquitous.

10116:Rhbdf2
gene id: 10116:Rhbdf2
uniprot id: F1LWZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

10116:Prok2
gene id: 10116:Prok2
uniprot id: A6IBH3
uniprot id: A6IBH4
uniprot id: F7EWJ2
uniprot id: Q8R413
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by CLOCK and BMAL1 heterodimers and light; inhibited by period genes (PER1, PER2 and PER3) and cryptochrome genes (CRY1 and CRY2).
messages: Belongs to the AVIT (prokineticin) family.
messages: Expressed at high levels in testis and at lower levels in brain, lung, ovary, spleen, thymus and uterus.
messages: May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle (By similarity).
messages: Secreted

10116:Gpr108
gene id: 10116:Gpr108
uniprot id: Q6P6V6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LU7TM family.
messages: Golgi apparatus membrane
messages: May play a role in intracellular immune modulation by activating NF-kappaB response and attenuating Toll-like-receptor response.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

10116:Phtf1
gene id: 10116:Phtf1
uniprot id: A0A8I5ZYW2
uniprot id: A0A8I6AB21
uniprot id: F1M8G0
names: Caution
names: Developmental Stage
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Endoplasmic reticulum membrane
messages: Highly expressed in testis.
messages: Interacts with FEM1B.
messages: Membrane
messages: The PHTF domain was initially defined as an atypical homeodomain, suggesting that this protein could act as a transcription regulator (By similarity). However, the protein is not found in the nucleus and mainly localizes in the endoplasmic reticulum membrane, suggesting that it does not act as a transcription factor (PubMed:12604659).
messages: The protein first appears in meiotic spermatocytes and becomes abundant in spermatids around stage III-IV (at protein level).
messages: cis-Golgi network membrane

10116:Tubb1
gene id: 10116:Tubb1
uniprot id: A6KL34
uniprot id: M0R8B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

10116:Faim2
gene id: 10116:Faim2
uniprot id: A6KCF9
uniprot id: O88407
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development (By similarity).
messages: Belongs to the BI1 family.
messages: Belongs to the BI1 family. LFG subfamily.
messages: Cell membrane
messages: Expressed at high levels on dendrites and to a lesser extent on the soma and axons of neurons in various regions of brain.
messages: Interacts with FAS/TNFRSF6 and BAX.
messages: Low expression was detected in brain and spinal cord at birth, increasing with age to highest levels in postnatal days 60 (P60).
messages: Membrane
messages: Membrane raft
messages: Postsynaptic cell membrane

10116:Itpripl1
gene id: 10116:Itpripl1
uniprot id: A6HQ01
uniprot id: Q66H52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

10116:Cd8b
gene id: 10116:Cd8b
uniprot id: G3V6V7
uniprot id: P05541
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Forms disulfide-linked heterodimers with CD8A at the cell surface. Interacts with CD3D; this interaction couples TCR-CD3 with CD8. Interacts with LCK.
messages: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells.
messages: Membrane
messages: Palmitoylated at the cytoplasmic tail and thereby targets the heterodimer CD8A/CD8B to lipid rafts unlike CD8A homodimers.
messages: Phosphorylated as a consequence of T-cell activation.

10116:Ppp1cb
gene id: 10116:Ppp1cb
uniprot id: A6HA24
uniprot id: P62142
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Inhibited by the toxins okadaic acid, tautomycin and microcystin Leu-Arg. The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress (By similarity).
messages: Nucleus
messages: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. The targeting or regulatory subunits determine the substrate specificity of PP1. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with PPP1R7 and PPP1R12C. Interacts with PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts with PPP1R12A and NUAK1; the interaction is direct. Interacts with TRIM28; the interaction is weak. Interacts with FOXP3. Interacts with RRP1B. Interacts with SERPINE1. Interacts with LZTR1 (By similarity).
messages: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E (By similarity).
messages: nucleolus
messages: nucleoplasm

10116:Tnfsf13
gene id: 10116:Tnfsf13
uniprot id: Q5PQL1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

10116:Cabp7
gene id: 10116:Cabp7
uniprot id: Q66H96
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Brain-specific. Restricted to the CA3 region of the hippocampus, entorhinal cortex, the antero-dorsal and antero-ventral thalamus and the inferior and superior colliculus.
messages: Cell membrane
messages: Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner.
messages: Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.
messages: The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.
messages: The calcium-binding affinity is not regulated by magnesium.
messages: perinuclear region
messages: trans-Golgi network membrane

10116:Slc3a1
gene id: 10116:Slc3a1
uniprot id: Q64319
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a chaperone that facilitates biogenesis and trafficking of functional transporter heteromers to the plasma membrane (PubMed:1376924, PubMed:1729674) (By similarity). Associates with SLC7A9 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1. SLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids. Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine. SLC7A9-SLC3A1 acts as a major transporter for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in early proximal tubules (PubMed:1376924, PubMed:1729674) (By similarity). Associates with SLC7A13 to form a functional complex that transports anionic and neutral amino acids via exchange or facilitated diffusion. SLC7A13-SLC3A1 may act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate (By similarity).
messages: Apical cell membrane
messages: Cell membrane
messages: Disulfide-linked heterodimer composed of the catalytic light subunit SLC7A9 and the heavy subunit SLC3A1. The heterodimer is the minimal functional unit. Assembles in non-covalently linked heterotetramers (dimers of heterodimers) and higher order oligomers; the oligomerization is mediated by SLC3A1 likely to prevent degradation in the endoplasmic reticulum and facilitate heteromer trafficking to the plasma membrane (By similarity) (PubMed:10506124). Disulfide-linked heterodimer composed of the catalytic light subunit SLC7A13 and the heavy subunit SLC3A1 (By similarity).
messages: Predominantly expressed in kidney and intestine. In kidney localized to the apical membrane of the proximal tubules.

10116:RGD1564463
gene id: 10116:RGD1564463
uniprot id: D3ZXB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:Tmem170a
gene id: 10116:Tmem170a
uniprot id: A6IZB2
uniprot id: M0R417
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

10116:Pappa2
gene id: 10116:Pappa2
uniprot id: A0A0G2JU68
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Purg
gene id: 10116:Purg
uniprot id: A6IVT5
uniprot id: D3ZYS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

10116:Pc
gene id: 10116:Pc
uniprot id: A0A8L2QDW8
uniprot id: A6HYX8
uniprot id: P52873
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of Lys-748 might play a role in catalytic activity regulation.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
messages: Homotetramer. Interacts (via the biotin carboxylation domain) with SIRT4.
messages: Mitochondrion matrix
messages: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
messages: This enzyme performs an important anaplerotic function in replenishing citric acid cycle intermediates that exit the mitochondrion for consumption in various pathways.

10116:Tiprl
gene id: 10116:Tiprl
uniprot id: A2VCX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIP41 family.
messages: Cytoplasm
messages: Interacts with PPP2CA. Interacts with PPP2CB, PPP4C and PPP6C. Interacts with IGBP1; the interaction is dependent on PPP2CA. Associates with a protein phosphatase 2A PP2A(C):IGBP1 complex. Interacts with PPP4C and PPP4R2 (By similarity).
messages: May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair (By similarity).

10116:Arl6ip4
gene id: 10116:Arl6ip4
uniprot id: A6J113
uniprot id: Q4V8I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARL6IP4 family.
messages: Interacts with ARL6. Interacts with ZCCHC17. Interacts with SRSF2.
messages: Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site.
messages: Nucleus speckle
messages: nucleolus

10116:Nabp1
gene id: 10116:Nabp1
uniprot id: Q5FVP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-B family. SOSS-B2 subfamily.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity).
messages: Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1 (By similarity).
messages: Nucleus

10116:Tent2
gene id: 10116:Tent2
uniprot id: Q5U315
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.
messages: Cytoplasm
messages: Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation. Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs.
messages: Interacts with CPEB1, CPEB2, CPSF1 and PABPC1 (By similarity). Interacts with QKI isoform QKI7; promoting recruitment to miRNA miR-122 and miR-122 stabilization (By similarity).
messages: Nucleus

10116:Adra2c
gene id: 10116:Adra2c
uniprot id: P22086
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.
messages: Cell membrane

10116:Pigl
gene id: 10116:Pigl
uniprot id: A6HFA2
uniprot id: O35790
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGL family.
messages: Endoplasmic reticulum membrane
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

10116:Svil
gene id: 10116:Svil
uniprot id: A0A8I6AHH0
uniprot id: A0A8I6AVE6
uniprot id: F1M155
names: Similarity
messages: Belongs to the villin/gelsolin family.

10116:Clcnkb
gene id: 10116:Clcnkb
uniprot id: E9PTA8
uniprot id: P51802
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Belongs to the chloride channel (TC 2.A.49) family. CLCNKB subfamily.
messages: Cell membrane
messages: Expressed predominantly in the kidney. Expressed in all segments of the nephron examined, including the S2 segment and the glomerulus.
messages: Expression is consitently weaker in the absence of BSND protein expression than it is in its presence. The half-life with BSND protein is much longer than that without it. Rapidly degraded without BSND protein, exhibiting a very short half-life of less than 1 hour.
messages: Golgi apparatus membrane
messages: Interacts with BSND.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.

10116:Them6
gene id: 10116:Them6
uniprot id: Q5XIE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THEM6 family.
messages: Secreted

10116:Pgpep1
gene id: 10116:Pgpep1
uniprot id: A6KA15
uniprot id: Q76IC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Monomer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

10116:Zfp503
gene id: 10116:Zfp503
uniprot id: A6KKT7
uniprot id: G3V7W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Elbow/Noc family.
messages: Nucleus

10116:Or1j16
gene id: 10116:Or1j16
uniprot id: A0A8I6AI95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Or1j16b
gene id: 10116:Or1j16b
uniprot id: A0A8I5ZWD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:RT1-A1
gene id: 10116:RT1-A1
uniprot id: Q6MGB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Involved in the presentation of foreign antigens to the immune system.
messages: Membrane

10116:Tas2r125
gene id: 10116:Tas2r125
uniprot id: A6IMB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

10116:Mpc1l
gene id: 10116:Mpc1l
uniprot id: A0A8I6A677
uniprot id: A6K000
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

10116:Lyrm9
gene id: 10116:Lyrm9
uniprot id: B2RZD7
names: Similarity
messages: Belongs to the complex I LYR family. LYRM9 subfamily.

10116:Abraxas2
gene id: 10116:Abraxas2
uniprot id: A6HX04
uniprot id: D4A415
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abro1 subfamily.
messages: Nucleus
messages: spindle pole

10116:LOC259244
gene id: 10116:LOC259244
uniprot id: F7EMS3
uniprot id: Q9JJI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

10116:Baiap2l1
gene id: 10116:Baiap2l1
uniprot id: Q3KR97
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with RAC1. Binds to F-actin. Interacts with FASLG (By similarity).
messages: May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection (By similarity).
messages: Phosphorylated on tyrosine in response to insulin.
messages: The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity).
messages: cytoskeleton

10116:Mecp2
gene id: 10116:Mecp2
uniprot id: A0A0G2JWK2
uniprot id: Q00566
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
messages: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
messages: In brain, by repeated injections of fluoxetine or cocaine.
messages: Interacts with FNBP3 (By similarity). Interacts with CDKL5 (By similarity). Interacts with ATRX; MECP2 recruits ATRX to pericentric heterochromatin in neuronal cells (PubMed:17296936). Interacts with NCOR2 (By similarity). Interacts with TBL1XR1; bridges interaction between MECP2 and NCOR1. Interacts with TBL1X; recruits TBL1X to the heterochromatin foci (By similarity).
messages: Nucleus
messages: Phosphorylated on Ser-421 by CaMK2 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation.
messages: Present in all adult somatic tissues tested.

10116:Atp5f1c
gene id: 10116:Atp5f1c
uniprot id: A0A8J8YGG0
uniprot id: Q6PCU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

10116:Arsi
gene id: 10116:Arsi
uniprot id: A6IXE7
uniprot id: Q32KJ8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts.
messages: Endoplasmic reticulum
messages: Secreted
messages: The oxidation of Cys-93 residue to 3-oxoalanine (also known as C(alpha)-formylglycine) by SUMF1/Sulfatase-modifying factor 1, seems critical for catalytic activity.

10116:Msmb
gene id: 10116:Msmb
uniprot id: A6KFX1
uniprot id: P97580
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-microseminoprotein family.
messages: Homodimer; Interacts with PI16.
messages: Secreted

10116:Or52ae7
gene id: 10116:Or52ae7
uniprot id: A6I799
uniprot id: D3ZCE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tmem132d
gene id: 10116:Tmem132d
uniprot id: Q76HP2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TMEM132 family.
messages: Expressed in mature oligodendrocytes in the brain.
messages: Expressed in the course of oligodendrocytes maturation.
messages: May serve as a cell-surface marker for oligodendrocyte differentiation.
messages: Membrane

10116:Dhx40
gene id: 10116:Dhx40
uniprot id: Q5XI69
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Probable ATP-dependent RNA helicase.

10116:Aph1a
gene id: 10116:Aph1a
uniprot id: A6K331
uniprot id: Q5PQQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

10116:Gas8
gene id: 10116:Gas8
uniprot id: A6IZY9
uniprot id: Q499U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DRC4 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker. Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner.
messages: Component of the nexin-dynein regulatory complex (N-DRC). Interacts with microtubules (By similarity). Interacts with SMO (By similarity). Interacts (via coiled-coil domains) with RAB3B (in GTP-bound form) (By similarity). Interacts with DRC1 (By similarity). Interacts with DRC7 (By similarity).
messages: Cytoplasm
messages: Golgi apparatus
messages: cilium
messages: cilium axoneme
messages: cilium basal body
messages: cytoskeleton
messages: flagellum
messages: flagellum axoneme

10116:Slc35b1
gene id: 10116:Slc35b1
uniprot id: Q6V7K3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane. Imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction. Regulates ER energy metabolism and protein biogenesis. Appears to be part of a calcium-dependent ER to cytosol low energy response axis, where calcium efflux from ER to the cytosol triggers ATP import into the ER lumen to maintain sufficient ATP supply. Provides ATP to ER chaperone HSPA5 that drives protein folding and trafficking in the ER. Can transport dATP, UTP or UDP in exchange for ATP, but the physiological relevance of this process remains to be established.
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Endoplasmic reticulum membrane
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

10116:Etv3
gene id: 10116:Etv3
uniprot id: A6J610
uniprot id: G3V813
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

10116:RGD1564651
gene id: 10116:RGD1564651
uniprot id: A0A8I6GDY5
names: Similarity
messages: Belongs to the protein kinase superfamily.

10116:Slc12a6
gene id: 10116:Slc12a6
uniprot id: A0A8I5Y638
uniprot id: A0A8I5ZZ36
uniprot id: A6HP46
uniprot id: A6HP47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

10116:Or10aa1
gene id: 10116:Or10aa1
uniprot id: A6JG95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Sec16b
gene id: 10116:Sec16b
uniprot id: Q75N33
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Liver, kidney, heart, spleen and brain.
messages: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes.
messages: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. Interacts with TFG. Interacts with SEC13.
messages: Stimulated by intracellular signaling factors.

10116:Slc28a3
gene id: 10116:Slc28a3
uniprot id: Q8VIH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Cell membrane
messages: Expressed in kidney; in the proximal tubule, glomerulus and cortical collecting duct.
messages: Homotrimer.
messages: Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine.

10116:Rprd1a
gene id: 10116:Rprd1a
uniprot id: D4AAU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
messages: Nucleus

10116:Catsperd
gene id: 10116:Catsperd
uniprot id: A0A8I6A393
uniprot id: A0A8L2QY57
uniprot id: B5DFM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane.
messages: Belongs to the CATSPERD family.
messages: Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG, CATSPERD, CATSPERE, CATSPERZ, C2CD6/CATSPERT, SLCO6C1, TMEM249, TMEM262 and EFCAB9 (By similarity). HSPA1 may be an additional auxiliary complex member (By similarity). The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel. The auxiliary CATSPERB, CATSPERG, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 and CATSPER2 respectively. SLCO6C1 interacts with CATSPERE and TMEM262/CATSPERH interacts with CATSPERB, further stabilizing the complex. C2CD6/CATSPERT interacts at least with CATSPERD and is required for targeting the CatSper complex in the flagellar membrane (By similarity).
messages: flagellum membrane

10116:Or2a57
gene id: 10116:Or2a57
uniprot id: D3ZFA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Arid3b
gene id: 10116:Arid3b
uniprot id: A6J4Y3
uniprot id: D3ZGC2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer with ARID3A. Interacts with unphosphorylated RB1.
messages: Homodimer.
messages: Nucleus
messages: Transcription factor.

10116:Gpr107
gene id: 10116:Gpr107
uniprot id: D3ZWZ9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the LU7TM family.
messages: Cell membrane
messages: Cleaved by FURIN to yield two fragments that remain associated via a disulfide bond.
messages: Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (PubMed:22933024, PubMed:26561648). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (PubMed:26561648).
messages: Widely expressed (PubMed:22933024, PubMed:26561648). Not detected in the duodenum, nor in the exocrine pancreas (PubMed:22933024).
messages: trans-Golgi network membrane

10116:Or2ak4c
gene id: 10116:Or2ak4c
uniprot id: A0A8I5Y6D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Trappc9
gene id: 10116:Trappc9
uniprot id: E9PU02
names: Similarity
messages: Belongs to the NIBP family.

10116:Zic1
gene id: 10116:Zic1
uniprot id: A6I226
uniprot id: F7FKS2
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

10116:Klhl25
gene id: 10116:Klhl25
uniprot id: Q4KLM4
names: Function
names: Subunit
messages: Component of the BCR(KLHL25) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL25 and RBX1.
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis. BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells.

10116:Mrpl51
gene id: 10116:Mrpl51
uniprot id: A6ILS8
uniprot id: D3ZPE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.
messages: Mitochondrion

10116:Nrxn2
gene id: 10116:Nrxn2
uniprot id: A0A8I5ZY56
uniprot id: Q63374
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the neurexin family.
messages: Brain (neuronal synapse).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
messages: O-glycosylated; contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins.
messages: Presynaptic cell membrane
messages: The laminin G-like domain 1 binds to NXPH1 (PubMed:9856994). Interacts with PATJ (PubMed:9647694). Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity). Specific isoforms bind neuroligins NLGN1, NLGN2 and NLGN3 (By similarity). Isoform 5c/alpha-2C binds to alpha-dystroglycan (PubMed:11470830). Interacts (via Laminin G-like 1 domain) with IGSF21 (Ig-like 1 domain) in a trans-interaction manner (By similarity). Interacts with CLSTN3 (By similarity).

10116:Smpx
gene id: 10116:Smpx
uniprot id: A6IPP6
uniprot id: Q925F0
names: Function
names: Similarity
messages: Belongs to the SMPX family.
messages: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.

10116:Reg3b
gene id: 10116:Reg3b
uniprot id: P25031
names: Activity Regulation
names: Disease Annotation
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a hormone in response to different stimuli. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. In pancreas, is able stimulate cell proliferation.
messages: Appears in pancreatic juice after induction of pancreatic inflammation. Secreted also by pituitary cells; the secretion there is stimulated by GH-releasing hormone and inhibited by somatostatin.
messages: Bactericidal C-type lectin which acts against several intestinal Gram-positive bacteria and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues.
messages: Constitutively expressed in intestine.
messages: Forms a hexameric membrane-permeabilizing oligomeric pore on membrane phospholipids. The hexamer is formed by three dimers related by helical symmetry. Forms filaments, filamentation traps pore complexes and limits damage to host cells. Interacts with EXTL3.
messages: Lipopolysaccharide inhibits pore-forming activity, explaining why is bactericidal for Gram-positive but not Gram-negative bacteria.
messages: Overexpressed during the acute phase of pancreatitis.
messages: Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.
messages: Secreted
messages: The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.

10116:Rab4a
gene id: 10116:Rab4a
uniprot id: P05714
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cytoplasm
messages: Early endosome membrane
messages: Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with RAB11FIP1, RABEP1, ZFYVE20 and RUFY1. Interacts (membrane-bound form) with NDRG1; the interaction involves NDRG1 in vesicular recycling of E-cadherin. Interacts (in GTP-bound form) with GRIPAP1 (via N-terminus) (PubMed:20098723). Interacts with RABEP1 and RBSN (By similarity). Does not interact with HPS4 (By similarity). Interacts with RABEP2; this interaction may mediate VEGFR2 cell surface expression (By similarity).
messages: Membrane
messages: Phosphorylated by CDK1 kinase during mitosis.
messages: Recycling endosome membrane
messages: Serotonylation of Gln-72 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity.
messages: Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (By similarity). Involved in protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).

10116:Icmt
gene id: 10116:Icmt
uniprot id: Q9WVM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane

10116:Utrn
gene id: 10116:Utrn
uniprot id: A0A0G2JW60
uniprot id: A0A8I5ZYU2
uniprot id: G3V7L1
uniprot id: O55147
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Actin binding affinity is primarily determined by CH domain 1.
messages: Homodimer. Interacts with the syntrophins SNTA1; SNTB1 and SNTB2. Interacts with SYNM. Interacts (via its WWW and ZZ domains) with DAG1 (via the PPXY motif of betaDAG1); the interaction is inhibited by the tyrosine phosphorylation of the PPXY motif of DAG1 (By similarity). Interacts with DTNB (PubMed:10545507). Interacts with PGM5 (PubMed:7890770).
messages: May play a role in anchoring the cytoskeleton to the plasma membrane.
messages: Postsynaptic cell membrane
messages: cytoskeleton

10116:Adh7
gene id: 10116:Adh7
uniprot id: P41682
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, aldehyde and omega-hydroxy fatty acids and their derivatives. Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives. Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal. Catalyzes in the oxidative direction with higher efficiency. Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation.
messages: Cytoplasm
messages: Homodimer.
messages: Preferentially expressed in stomach.
messages: Retinol oxidation is inhibited by the detergent Tween 80. Ethanol inhibits both all-trans-retinol and 9-cis-retinol oxidation. 13-cis-retinol is an effective competitive inhibitor of the 9-cis-retinol oxidation. All-trans-retinoic acid is a powerful inhibitor of all-trans-retinol oxidation. 13-cis-retinoic acid is a powerful inhibitor of all-trans-retinol oxidation (By similarity). Cimetidine and ranitidine inhibited ethanol oxidation (PubMed:9600267).

10116:Gja3
gene id: 10116:Gja3
uniprot id: G3V747
uniprot id: P29414
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A connexon is composed of a hexamer of connexins.
messages: A hemichannel or connexon is composed of a hexamer of connexins. A functional gap junction is formed by the apposition of two hemichannels. Forms heteromeric channels with GJA8.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Detected in eye lens (at protein level). Most abundant in lens, but also present in heart and kidney.
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: Structural component of lens fiber gap junctions (Probable). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (Probable).
messages: gap junction

10116:Gng3
gene id: 10116:Gng3
uniprot id: A6HZV1
uniprot id: G3V8K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: Membrane

10116:Ccs
gene id: 10116:Ccs
uniprot id: Q9JK72
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 copper ions per subunit.
messages: Cytoplasm
messages: Delivers copper to copper zinc superoxide dismutase (SOD1).
messages: Homodimer, and heterodimer with SOD1. Interacts with COMMD1. Interacts with XIAP/BIRC4. Interacts with SLC31A1(via C-terminal domain); this interaction is Cu(1+)-mediated. The heterodimer CCS:SOD1 interacts with SLC31A1; this heterotrimer is Cu(1+)-mediated and its maintenance is regulated through SOD1 activation.
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.
messages: Ubiquitinion by XIAP/BIRC4 leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. XIAP/BIRC4 preferentially ubiquitinates at Lys-241.

10116:Rpl22l1
gene id: 10116:Rpl22l1
uniprot id: A6IHJ4
uniprot id: F7EY34
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

10116:Slc35e2b
gene id: 10116:Slc35e2b
uniprot id: A6IUQ8
uniprot id: D4A0R5
names: Subcellular Location Annotation
messages: Membrane

10116:Brinp2
gene id: 10116:Brinp2
uniprot id: A6ID37
uniprot id: Q8K1M8
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the BRINP family.
messages: Expressed from 11.5 dpc.
messages: Expressed in olfactory bulb, cerebellum and neuronal layers in hippocampus.
messages: Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition.
messages: Secreted

10116:Kcne5
gene id: 10116:Kcne5
uniprot id: A5HKJ1
uniprot id: M0RCZ4
names: Similarity
messages: Belongs to the potassium channel KCNE family.

10116:Nsun5
gene id: 10116:Nsun5
uniprot id: A6J0D2
uniprot id: G3V660
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

10116:Tmem70
gene id: 10116:Tmem70
uniprot id: A6JF97
uniprot id: D3Z946
names: Similarity
messages: Belongs to the TMEM70 family.

10116:Rap1b
gene id: 10116:Rap1b
uniprot id: Q62636
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner.
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell junction
messages: Cell membrane
messages: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity).
messages: Heterodimer with RAP1GAP (By similarity). Interacts with EPAC2 (By similarity). Interacts with SGSM1 (By similarity). Interacts with SGSM2 (By similarity). Interacts with SGSM3 (By similarity). Interacts with KRIT1 (By similarity). Interacts with RAP1GDS1 (By similarity).
messages: cytosol

10116:Hs3st1
gene id: 10116:Hs3st1
uniprot id: Q9ESG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family.
messages: Golgi apparatus lumen
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site (By similarity).

10116:Prdx3
gene id: 10116:Prdx3
uniprot id: Q9Z0V6
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Early endosome
messages: Homodimer; disulfide-linked, upon oxidation. 6 homodimers assemble to form a ring-like dodecamer. Interacts with NEK6. Interacts with LRRK2. Interacts with MAP3K13 (By similarity). Interacts with RPS6KC1 (via PX domain).
messages: Mitochondrion
messages: Phosphorylated by LRRK2; phosphorylation reduces perodixase activity.
messages: S-palmitoylated.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (By similarity). Required for the maintenance of physical strength (By similarity).
messages: Ubiquitous.

10116:Cyb5a
gene id: 10116:Cyb5a
uniprot id: A6K5L8
uniprot id: P00173
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b5 family.
messages: Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. It is also involved in several steps of the sterol biosynthesis pathway, particularly in the C-6 double bond introduction during the C-6 desaturation.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

10116:Ccnq
gene id: 10116:Ccnq
uniprot id: Q4QQW5
names: Function
names: Similarity
names: Subunit
messages: Activating cyclin for the cyclin-associated kinase CDK10.
messages: Associates with CDK10 to promote its kinase activity.
messages: Belongs to the cyclin family. Cyclin-like FAM58 subfamily.

10116:Isl2
gene id: 10116:Isl2
uniprot id: P50480
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with LHX4.
messages: Nucleus
messages: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.

10116:Tf
gene id: 10116:Tf
uniprot id: A6I2I8
uniprot id: P12346
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transferrin family.
messages: Expressed by the liver and secreted in plasma.
messages: Monomer.
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

10116:Rpl26
gene id: 10116:Rpl26
uniprot id: A6HFL4
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

10116:Mix23
gene id: 10116:Mix23
uniprot id: A6IRD9
uniprot id: D4A305
names: Similarity
messages: Belongs to the MIX23 family.

10116:Gngt1
gene id: 10116:Gngt1
uniprot id: A6K2B2
uniprot id: D4AAI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: Membrane

10116:Gpr174
gene id: 10116:Gpr174
uniprot id: A6IV67
uniprot id: D3ZWS1
names: Subcellular Location Annotation
messages: Membrane

10116:Rps3a
gene id: 10116:Rps3a
uniprot id: A6J5Z3
uniprot id: P49242
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylated at Tyr-155 by PARP1 in presence of HPF1.
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity).
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus
messages: The protein designated S3b has the same amino acid sequence as S3a except that it lacks the C-terminal 12 residues. It is probable that S3a is converted by proteolysis, either physiologically or fortuitously, to S3b.
messages: nucleolus

10116:Smim14
gene id: 10116:Smim14
uniprot id: A6JDD7
uniprot id: Q498C7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

10116:Slc5a7
gene id: 10116:Slc5a7
uniprot id: Q9JMD7
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Choline uptake activity is regulated by SLC5A7/CHT1 internalization (inactive form) from the cell surface and recycling of internalized SLC5A7/CHT1 into the cell surface (active form) (By similarity). Activated by extracellular chloride ion (By similarity). Specifically inhibited by nanomolar concentrations of hemicholinium 3 (PubMed:10649566).
messages: Early endosome membrane
messages: Expressed in basal forebrain, brain stem, spinal chord, and striatum (PubMed:10649566). Specific for cholinergic neurons (PubMed:10649566).
messages: High-affinity Na(+)-coupled choline transmembrane symporter (PubMed:10649566). Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry (By similarity). Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion (By similarity). Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release (By similarity). SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials (By similarity). Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity (By similarity).
messages: Homooligomerizes at cell surface (By similarity). Interacts with SEC14L1; may regulate SLC5A7 (PubMed:17092608).
messages: Phosphorylated.
messages: Presynaptic cell membrane
messages: The C-terminal dileucine-like motif (DKTILV) controls SLC5A7/CHT1 internalization in clathrin-coated vesicles to early endosomes as well as choline transporter activity.
messages: axon
messages: synaptic vesicle membrane

10116:Ankrd13a
gene id: 10116:Ankrd13a
uniprot id: Q5U313
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

10116:Synpo2
gene id: 10116:Synpo2
uniprot id: D4A702
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptopodin family.
messages: Cytoplasm
messages: Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks. At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines (By similarity). Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (PubMed:23434281). Involved in regulation of cell migration. May be a tumor suppressor (By similarity).
messages: May self-associate in muscle cells under oxidative stress. Binds F-actin. Interacts with ACTN2; ACTN2 is proposed to anchor SYOP2 at Z lines in mature myocytes. Interacts with AKAP6, PPP3CA and CAMK2A. Interacts (phosphorylated form) with YWHAB; YWHAB competes with ACTN2 for interaction with SYNPO2. Interacts with KPNA2; mediating nuclear import of SYNOP2; dependent on interaction with YWHAB. Interacts with IPO13; may be implicated in SYNOP2 nuclear import. Interacts with ZYX, FLNC, ILK (By similarity). Interacts with BAG3 (via WW 1 domain) (By similarity). May associate with the CASA complex consisting of HSPA8, HSPB8 and BAG3 (PubMed:23434281). Interacts with VPS18 (By similarity).
messages: Nucleus
messages: Phosphorylated by PKA, and by CaMK2 at multiple sites. Dephosphorylated by calcineurin at Ser-558 and Thr-605; abrogating interaction with YWHAB and impairing nuclear import.
messages: The PPPY motif interacts with the WW domain 1 of BAG3.
messages: Z line
messages: cytoskeleton
messages: focal adhesion

10116:Vgf
gene id: 10116:Vgf
uniprot id: P20156
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: By nerve growth factor.
messages: Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells. VGF and several of the derived peptides are present in the brain.
messages: Interacts with HSPA8 on cell membrane (By similarity). Interacts with C3AR1 (By similarity). Interacts with C1QBP (PubMed:24106277).
messages: Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure.
messages: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (PubMed:24704271). Stimulates also feeding behavior in an orexin-dependent manner in the hypothalamus (PubMed:20551287). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (PubMed:28213131).
messages: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons.
messages: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation (By similarity). Induces also insulin secretion in insulinoma cells by increasing intracellular calcium mobilization (PubMed:25917832).
messages: Secreted
messages: Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis (PubMed:28123945, PubMed:16983076). Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes (PubMed:23940034, PubMed:28123945). Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity (PubMed:24106277, PubMed:19466987).
messages: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (PubMed:12065665, PubMed:7595538). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity).
messages: secretory vesicle

10116:Ranbp17
gene id: 10116:Ranbp17
uniprot id: A6HDG6
uniprot id: D3ZYN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

10116:C4b
gene id: 10116:C4b
uniprot id: A0A9K3Y872
uniprot id: Q6MG90
names: Subcellular Location Annotation
messages: Secreted

10116:Tspan3
gene id: 10116:Tspan3
uniprot id: F7F5Z9
uniprot id: Q66H06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

10116:Uqcc3
gene id: 10116:Uqcc3
uniprot id: A6HZW8
uniprot id: P0CD94
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III(CIII) or cytochrome b-c1 complex) (By similarity). Interacts with UQCC1 (By similarity). Forms a complex, named COMC, composed of UQCC1, UQCC2; UQCC3 and UQCC4; mediates MT-CYB hemylation and association with the first nuclear-encoded complex III subunit UQCRQ (By similarity).
messages: Belongs to the UQCC3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Probably cleaved by OMA1 under mitochondrial stress conditions.
messages: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.

10116:Rasgrp3
gene id: 10116:Rasgrp3
uniprot id: A0A0G2KAU4
uniprot id: A6H9X0
uniprot id: D3ZZN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RASGRP family.
messages: cytosol

10116:Rpl36al
gene id: 10116:Rpl36al
uniprot id: B2RYQ8
uniprot id: P83883
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

10116:Arf4
gene id: 10116:Arf4
uniprot id: A6KMJ6
uniprot id: P61751
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Forms a complex containing RAB11A, ASAP1, RAB3IP, RAP11FIP3 and ARF4; the complex promotes preciliary trafficking; the complex binds to RHO in photoreceptor cells and promotes RHO ciliary transport.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (By similarity).
messages: Golgi apparatus
messages: Membrane

10116:Cym
gene id: 10116:Cym
uniprot id: Q9JJX1
names: Similarity
messages: Belongs to the peptidase A1 family.

10116:Ngf
gene id: 10116:Ngf
uniprot id: A6K3I9
uniprot id: P25427
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NGF-beta family.
messages: Detected in the granule and pyramidal cell layer in the hippocampus.
messages: Endosome lumen
messages: Homodimer. The homodimer interacts with a single NTRK1 chain. The homodimer interacts with a single NGFR chain (By similarity). The NGF dimer interacts with a single SORCS2 chain (via extracellular domain). The NGF precursor (proNGF) binds to a receptor complex formed by SORT1 and NGFR, which leads to NGF endocytosis. Both mature NGF and the immature NGF precursor (proNGF) interact with SORCS2 and with the heterodimer formed by SORCS2 and NGFR (via extracellular domains). The NGF precursor (proNGF) has much higher affinity for SORCS2 than mature NGF. The NGF precursor (proNGF) has much higher affinity for SORT1 than mature NGF (By similarity). Interacts with ADAM10 in a divalent cation-dependent manner (By similarity).
messages: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity).
messages: Secreted

10116:Sf3b5
gene id: 10116:Sf3b5
uniprot id: A6JP52
uniprot id: D4A5T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

10116:Adar
gene id: 10116:Adar
uniprot id: P55266
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Does not affect polyomavirus replication but provides protection against virus-induced cytopathic effects. Essential for embryonic development and cell survival and plays a critical role in the maintenance of hematopoietic stem cells (By similarity).
messages: Cytoplasm
messages: Detected in brain.
messages: Homodimer. Homodimerization is essential for its catalytic activity. Isoform 5 can form heterodimers with ADARB1/ADAR2. Isoform 1 interacts with ILF2/NF45 and ILF3/NF90. Binding to ILF3/NF90 up-regulates ILF3-mediated gene expression. Isoform 1 and isoform 5 (via DRBM 3 domain) interact with TNPO1. Isoform 5 (via DRBM domains) interacts with XPO5. Isoform 1 and isoform 5 can interact with EIF2AK2/PKR and UPF1.
messages: Nucleus
messages: Sumoylation reduces RNA-editing activity.
messages: The first DRADA repeat binds Z-DNA.
messages: The third dsRNA-binding domain (DRBM 3) contains an additional N-terminal alpha-helix that is part of a bi-partite nuclear localization signal, together with the sequence immediately C-terminal to DRBM 3. The presence of DRBM 3 is important to bring together the N-terminal and the C-terminal part of the bi-partite nuclear localization signal for import mediated by TNPO1. RNA binding interferes with nuclear import.

10116:Mthfd2l
gene id: 10116:Mthfd2l
uniprot id: D3ZUA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Bifunctional mitochondrial folate-interconverting enzyme that has both NAD/NADP-dependent methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities.
messages: Has no NAD/NADP-dependent methylenetetrahydrofolate dehydrogenase activity.
messages: Mitochondrion inner membrane
messages: Widely expressed.

10116:Noc4l
gene id: 10116:Noc4l
uniprot id: A6J298
uniprot id: Q5I0I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: Nucleus membrane
messages: nucleolus

10116:Syt10
gene id: 10116:Syt10
uniprot id: O08625
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (PubMed:18508778).
messages: Homodimer; disulfide-linked via the cysteine motif. Can also form heterodimers with SYT3, SYT6, SYT7 and SYT9.
messages: The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.
messages: The first C2 domain mediates Ca(2+)-dependent phospholipid binding.
messages: secretory vesicle membrane

10116:Ing3
gene id: 10116:Ing3
uniprot id: A6IE55
uniprot id: Q498T3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity).
messages: Interacts with H3K4me3 and to a lesser extent with H3K4me2 (By similarity). Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC. HTATTIP/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4. Component of a SWR1-like complex (By similarity).
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

10116:Etv1
gene id: 10116:Etv1
uniprot id: B5DEZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

10116:Traf3
gene id: 10116:Traf3
uniprot id: A6KBQ0
uniprot id: D3Z9G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

10116:Itpkc
gene id: 10116:Itpkc
uniprot id: A6J9B8
uniprot id: Q80ZG2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by calcium/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4.
messages: Belongs to the inositol phosphokinase (IPK) family.
messages: Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (PubMed:12649294). Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.
messages: Cytoplasm
messages: Highly expressed in tongue epithelium, taste papilla, heart, brain and testis. Weakly expressed in lung, liver and kidney.
messages: Nucleus

10116:Or12d2
gene id: 10116:Or12d2
uniprot id: Q6MFW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:LOC691495
gene id: 10116:LOC691495
uniprot id: F1M7I3
names: Similarity
messages: Belongs to the pro/parathymosin family.

10116:Ppan
gene id: 10116:Ppan
uniprot id: Q5FVQ2
names: Subcellular Location Annotation
messages: nucleolus

10116:RT1-CE3
gene id: 10116:RT1-CE3
uniprot id: Q6MG38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Membrane

10116:Or4x5
gene id: 10116:Or4x5
uniprot id: A0A0G2K325
uniprot id: A6HN58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tubb6
gene id: 10116:Tubb6
uniprot id: A6IXU7
uniprot id: F7FF15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

10116:Ins2
gene id: 10116:Ins2
uniprot id: A6HY81
uniprot id: P01323
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

10116:Cnot2
gene id: 10116:Cnot2
uniprot id: A0A0G2KB82
uniprot id: A0A8I5Y9U2
uniprot id: A0A8I5ZXR1
uniprot id: A6IGP0
uniprot id: Q5PPJ8
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

10116:Car1
gene id: 10116:Car1
uniprot id: B0BNN3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide. Can hydrate cyanamide to urea.
messages: Cytoplasm
messages: Inhibited by acetazolamide.

10116:Heg1
gene id: 10116:Heg1
uniprot id: A0A8I6AEF2
uniprot id: F1M9I4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Gulo
gene id: 10116:Gulo
uniprot id: A0A140TAC7
uniprot id: A6K6L4
uniprot id: P10867
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate.

10116:Cldn24
gene id: 10116:Cldn24
uniprot id: A6JPK3
uniprot id: D4A2B4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

10116:Tead3
gene id: 10116:Tead3
uniprot id: Q4KLN9
uniprot id: Q5U2N6
names: Subcellular Location Annotation
messages: Nucleus

10116:Efna3
gene id: 10116:Efna3
uniprot id: A0A0G2JV56
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Rcan1
gene id: 10116:Rcan1
uniprot id: A0A8I6AFT2
uniprot id: A6JLJ9
uniprot id: A6JLK0
uniprot id: Q6IN33
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
messages: Interacts with RAF1, PPP3R1 and PPP3CA.
messages: Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.

10116:Stab1
gene id: 10116:Stab1
uniprot id: A0A8I5Y895
uniprot id: D3ZWH1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Olfm5
gene id: 10116:Olfm5
uniprot id: A6I7E3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Or1ad5
gene id: 10116:Or1ad5
uniprot id: D3ZEC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Anxa4
gene id: 10116:Anxa4
uniprot id: A6IAZ2
uniprot id: F7ERI2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Zymogen granule membrane

10116:Zc3h12d
gene id: 10116:Zc3h12d
uniprot id: A6JP21
uniprot id: D4A0I4
names: Similarity
messages: Belongs to the ZC3H12 family.

10116:Cryba1
gene id: 10116:Cryba1
uniprot id: A6HGZ0
uniprot id: P14881
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity). Interacts with CRYBA1 (By similarity).
messages: Specific cleavages in the N-terminal arm occur during lens maturation and give rise to several truncated forms.
messages: The initiator methionine for isoform A1 is removed. The new N-terminal amino acid is then N-acetylated (By similarity).

10116:Or12e8
gene id: 10116:Or12e8
uniprot id: A6HMY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tmed7
gene id: 10116:Tmed7
uniprot id: D3ZTX0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMP24/GP25L family.
messages: COPI-coated vesicle membrane
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: N-linked glycosylated in complex form containing terminal sialic acid.
messages: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications (By similarity).
messages: Predominantly monomeric and to lesser extent homodimeric in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and trans-Golgi network. Oligomerizes with other members of the EMP24/GP25L family such as TMED2, TMED9 and TMED10. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED7 (By similarity).
messages: cis-Golgi network membrane

10116:Olr1049
gene id: 10116:Olr1049
uniprot id: M0RCV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Phactr3
gene id: 10116:Phactr3
uniprot id: A6KMF0
uniprot id: Q6RFY2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Binds actin and PPP1CA; thus inhibiting the protein phosphatase 1 (PP1) activity.
messages: Diffusely expressed throughout the brain cortex, with highest levels in the cortex and the hippocampus and lower levels in the striatum and thalamus.
messages: Nucleus matrix

10116:Rrm2
gene id: 10116:Rrm2
uniprot id: A6HAY1
uniprot id: Q4KLN6
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm
messages: Heterodimer of a large and a small subunit. Interacts (via Cy motif and when phosphorylated at Thr-33) with CCNF; the interaction occurs exclusively in G2 and early M (By similarity).
messages: Nucleus
messages: Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling (By similarity). Phosphorylated on Thr-33 by CDK1 and CDK2; predominantly in G2 and M phase (By similarity).
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Inhibits Wnt signaling (By similarity).
messages: Two distinct regulatory sites have been defined: the specificity site, which controls substrate specificity, and the activity site which regulates overall catalytic activity. A substrate-binding catalytic site, located on M1, is formed only in the presence of the second subunit M2 (By similarity).
messages: Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex; leading to its degradation by the proteasome.

10116:Slc38a7
gene id: 10116:Slc38a7
uniprot id: Q6JWR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Interacts with the mTORC1 complex; this interaction mediates the recruitment of mTORC1 to the lysosome and its subsequent activation.
messages: Lysosome membrane
messages: Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation. The transport activity requires an acidic lysosomal lumen.
messages: axon

10116:Alg9
gene id: 10116:Alg9
uniprot id: A6J4G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:Arrdc5
gene id: 10116:Arrdc5
uniprot id: A6KQY8
uniprot id: M0R521
names: Similarity
messages: Belongs to the arrestin family.

10116:Gpsm3
gene id: 10116:Gpsm3
uniprot id: Q6MG88
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins.
messages: The GoLoco 1 and/or GoLoco 3 domains exhibit GDI activity towards GDP-bound G(i) alpha protein, but not the GoLoco 2 domain.

10116:Hcrt
gene id: 10116:Hcrt
uniprot id: A6HJ60
uniprot id: O55232
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the orexin family.
messages: Binds to orexin receptor HCRTR2/OX2R only (PubMed:9491897). Stimulates food intake (PubMed:9491897). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (PubMed:9879756).
messages: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity (PubMed:9491897). Stimulates food intake (PubMed:9491897). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (PubMed:9879756).
messages: By nutritional state, up-regulated by fasting, fluid deprivation and insulin-induced hypoglycemia. Orexin-A immunoreactivity varies diurnally and peaks during the dark phase, in the pons and the location of locus coeruleus.
messages: Cytoplasmic vesicle
messages: Detected in the brain as early as embryonic day 18, but expression increases dramatically after the third postnatal week.
messages: Endoplasmic reticulum
messages: Mainly expressed in the brain, with expression in neurons in the dorsal lateral hypothalamic area (at protein level) (PubMed:9419374). Produced by a small group of neurons restricted to the lateral and posterior hypothalamus and perifornical areas (PubMed:9491897). Positive neurons project widely throughout the entire neuroaxis (PubMed:9491897). Particularly abundant projections in the cerebral cortex, olfactory bulb, hippocampus, amygdala, septum, diagonal band of Broca, bed nucleus of the stria terminalis, thalamus, anterior and posterior hypothalamus, midbrain, brainstem, and spinal cord (PubMed:9491897). Also expressed in the enteric nervous system and pancreas (PubMed:9491897). In small amount, also detected in the testis (PubMed:9491897).
messages: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions (PubMed:9491897, PubMed:11340621, PubMed:11283317). A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested (PubMed:9491897). A modulation effect on luteinizing hormone-releasing hormone (LHRH) secretion also suggests a more minor contribution to the regulation of reproductive function (PubMed:9879756, PubMed:11340621).
messages: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested.
messages: Rough endoplasmic reticulum
messages: Specific enzymatic cleavages at paired basic residues yield the different active peptides.
messages: Synapse
messages: Vesicle

10116:Acbd4
gene id: 10116:Acbd4
uniprot id: Q6DGF9
names: Function
messages: Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.

10116:Chi3l1
gene id: 10116:Chi3l1
uniprot id: Q9WTV1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although it belongs to the glycosyl hydrolase 18 family, Leu-138 is present instead of the conserved Glu which is an active site residue. Therefore this protein lacks chitinase activity.
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Monomer.
messages: extracellular space
messages: perinuclear region

10116:Gstm7
gene id: 10116:Gstm7
uniprot id: A6HUW1
uniprot id: P08009
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Gstm7 is the putative ortholog of human GSTM2.
messages: Homodimer.
messages: Yb subclass selectively binds steroid hormones.

10116:Serbp1
gene id: 10116:Serbp1
uniprot id: A6KF47
uniprot id: A6KF48
uniprot id: Q6AXS5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with mature 80S ribosomes (By similarity). Interacts with EEF2/eEF2; interaction sequesters EEF2/eEF2 at the A-site of the ribosome, thereby blocking the interaction sites of the mRNA-tRNA complex, promoting ribosome stabilization and hibernation. Interacts with SPIN1 (By similarity). Interacts with CHD3 and TDRD3 (By similarity). Interacts with ZDHHC17 (via ANK repeats) (By similarity).
messages: Belongs to the SERBP1-HABP4 family.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylation by MTOR inhibits SERBP1 and relieves ribosome hibernation.
messages: Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation (By similarity).
messages: perinuclear region

10116:Rnf10
gene id: 10116:Rnf10
uniprot id: Q5XI59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNF10 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling. Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome. Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation. The action of RNF10 in iRQC is counteracted by USP10 (By similarity). May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression (PubMed:18941509). Acts as a regulator of Schwann cell differentiation and myelination (PubMed:18941509).
messages: Interacts with MEOX2.
messages: Nucleus

10116:Chaf1a
gene id: 10116:Chaf1a
uniprot id: M0R3S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHAF1A family.
messages: Nucleus

10116:Tent5a
gene id: 10116:Tent5a
uniprot id: A6I1T0
uniprot id: D3ZH34
names: Similarity
messages: Belongs to the TENT family.

10116:Eif1
gene id: 10116:Eif1
uniprot id: B0K008
names: Similarity
messages: Belongs to the SUI1 family.

10116:Eda
gene id: 10116:Eda
uniprot id: A0A096MIW0
uniprot id: A0A0U5J6T2
names: Similarity
messages: Belongs to the tumor necrosis factor family.

10116:Stbd1
gene id: 10116:Stbd1
uniprot id: Q5FVN1
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes.
messages: Endoplasmic reticulum membrane
messages: Interacts with the ATG8 family proteins GABARAP and GABARAPL1 (By similarity). Interacts with several glycogen-associated proteins, such as GYS2 (liver glycogen synthase), GDE (glycogen debranching enzyme), GBE1 (glycogen branching enzyme 1) and EPM2A (Laforin) (By similarity).
messages: Preautophagosomal structure membrane
messages: T-tubule
messages: The C-terminal CBM20 domain is required for the interaction with glycogen.
messages: The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family protein GABARAPL1.
messages: Ubiquitinated, which leads to proteasomal degradation.

10116:Spata32
gene id: 10116:Spata32
uniprot id: Q66H17
names: Subunit
names: Tissue Specificity
messages: Abundantly expressed in testes. Expressed in germ cells, but not in Sertoli or Leydig cells of the adult testis. Localized at the acrosomal region of the round and elongated spermatids at stages VIII-X.
messages: Interacts with syntaxin-1 and ACTB.

10116:Taf5
gene id: 10116:Taf5
uniprot id: A6JHP4
uniprot id: D3ZH66
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

10116:Lpgat1
gene id: 10116:Lpgat1
uniprot id: A6JH01
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

10116:Ctnnd1
gene id: 10116:Ctnnd1
uniprot id: A0A0G2JXM1
uniprot id: A6HMQ5
names: Similarity
messages: Belongs to the beta-catenin family.

10116:Atg16l2
gene id: 10116:Atg16l2
uniprot id: A0A8I6AAM8
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

10116:Lamc1
gene id: 10116:Lamc1
uniprot id: F1MAA7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

10116:Actl7b
gene id: 10116:Actl7b
uniprot id: A6KDR2
uniprot id: Q4QR76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

10116:Ptpre
gene id: 10116:Ptpre
uniprot id: B2GV87
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A catalytically active cytoplasmic form (p65) is produced by proteolytic cleavage of either isoform 1, isoform 2 or isoform 3.
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).
messages: Isoform 1 and isoform 2 are phosphorylated on tyrosine residues by tyrosine kinase Neu.
messages: Isoform 1 is highly expressed in the brain, lung, spleen and testis. Isoform 2 is highly expressed in thymus, spleen and lung. Isoform 1 and isoform 2 are expressed in primary hepatocytes.
messages: Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). Acts as a negative regulator of insulin receptor (IR) signaling and is involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver.
messages: Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity).
messages: Monomer. Isoform 2: Homodimer. Can form oligomers. Dimerization is increased by oxidative stress and decreased by EGFR. Isoform 2 interacts with GRB2 (By similarity).
messages: N-glycosylated.
messages: Produced by alternative initiation at Met-85 of isoform 1.
messages: Produced by alternative promoter usage.
messages: The tyrosine-protein phosphatase 2 domain (D2) mediates dimerization. The extreme N- and C- termini of the D2 domain act to inhibit dimerization and removal of these sequences increases dimerization and inhibits enzyme activity (By similarity).

10116:Krt1
gene id: 10116:Krt1
uniprot id: A0A0G2JST3
uniprot id: Q6IMF3
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Cytoplasm
messages: Heterotetramer of two type I and two type II keratins (By similarity). Heterodimer with KRT10 (By similarity). Two heterodimers of KRT1 and KRT10 form a heterotetramer (By similarity). Forms a heterodimer with KRT14; the interaction is more abundant in the absence of KRT5 (By similarity). Interacts with ITGB1 in the presence of RACK1 and SRC, and with RACK1 (By similarity). Interacts with C1QBP; the association represents a cell surface kininogen receptor (By similarity). Interacts with EPPK1; interaction is dependent of higher-order structure of intermediate filament (By similarity).
messages: May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity).
messages: Membrane
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
messages: Undergoes deimination of some arginine residues (citrullination).

10116:Or13c7b
gene id: 10116:Or13c7b
uniprot id: A6IJ55
uniprot id: D4AC79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Rfpl4a
gene id: 10116:Rfpl4a
uniprot id: D4ABM4
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with PSMB1, UBE2A and CCNB1.
messages: Nucleus

10116:Necab1
gene id: 10116:Necab1
uniprot id: Q9ESB5
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with STX1. May interact with CPNE6.

10116:Rpl31
gene id: 10116:Rpl31
uniprot id: A6INL0
uniprot id: P62902
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

10116:Rcor2
gene id: 10116:Rcor2
uniprot id: Q5FWT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoREST family.
messages: May act as a component of a corepressor complex that represses transcription.
messages: Nucleus

10116:Stradb
gene id: 10116:Stradb
uniprot id: A6IP88
uniprot id: D3ZVH0
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

10116:B3gnt3
gene id: 10116:B3gnt3
uniprot id: A6K9X8
uniprot id: D3ZX31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

10116:Prl8a7
gene id: 10116:Prl8a7
uniprot id: A0A0G2JTQ7
uniprot id: P33578
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the somatotropin/prolactin family.
messages: Mid to late gestation (gestation day 15).
messages: Placental basal zone cells.
messages: Secreted

10116:Slc26a6
gene id: 10116:Slc26a6
uniprot id: A6I392
uniprot id: A6I393
uniprot id: D3Z9I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

10116:Atg16l1
gene id: 10116:Atg16l1
uniprot id: A0A0G2K9U6
uniprot id: A0A8I6GLZ1
uniprot id: D3ZFK6
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

10116:Thbs4
gene id: 10116:Thbs4
uniprot id: A0A0G2K7L8
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Lbp
gene id: 10116:Lbp
uniprot id: F7FLI1
uniprot id: Q3MID7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
messages: Secreted
messages: When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

10116:E2f1
gene id: 10116:E2f1
uniprot id: A6KHZ9
uniprot id: O09139
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation stimulates DNA-binding. Enhanced under stress conditions such as DNA damage and inhibited by retinoblastoma protein RB1. Regulated by KAP1/TRIM28 which recruits HDAC1 to E2F1 resulting in deacetylation (By similarity).
messages: BIRC2/c-IAP1 stimulates its transcriptional activity.
messages: Belongs to the E2F/DP family.
messages: Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Binds TOPBP1 and EAPP. Interacts with ARID3A. Interacts with TRIM28; the interaction inhibits E2F1 acetylation through recruiting HDAC1 and represses its transcriptional activity. Interaction with KAT2B; the interaction acetylates E2F1 enhancing its DNA-binding and transcriptional activity. Interacts with BIRC2/c-IAP1 (via BIR domains). The complex TFDP1:E2F1 interacts with CEBPA; the interaction prevents CEBPA binding to target genes promoters and represses its transcriptional activity. Interacts with RRP1B. Interacts with HCFC1. Interacts with KMT2E; the interaction is probably indirect and is mediated via HCFC1. Interacts with DCAF5 and L3MBTL3; the interaction requires methylation at Lys-183 and is necessary to target E2F1 for ubiquitination by the CRL4-DCAF5 E3 ubiquitin ligase complex (By similarity).
messages: Methylation at Lys-183 by SETD7 promotes E2F1 ubiquitin-dependent proteasomal degradation.
messages: Nucleus
messages: Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation by CHEK2 stabilizes E2F1 upon DNA damage and regulates its effect on transcription and apoptosis. Phosphorylation at Ser-398 by GSK3B promotes interaction with USP11, leading to its deubiquitination and stabilization.
messages: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters. Directly activates transcription of PEG10. Positively regulates transcription of RRP1B.
messages: Ubiquitinated via 'Lys-63'-linked ubiquitin, leading to its degradation. Deubiquitinated by USP11 follwong phosphorylation by GSK3B, promoting its stability.

10116:Sec61g
gene id: 10116:Sec61g
uniprot id: A6JPX6
uniprot id: B5DER8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:Kif13a
gene id: 10116:Kif13a
uniprot id: A6J709
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

10116:Dpysl3
gene id: 10116:Dpysl3
uniprot id: A0A8I6AUS8
uniprot id: A6J3L8
uniprot id: A6J3L9
uniprot id: Q62952
names: Caution
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At 17 dpc, isoform 2 is expressed in the CNS and PNS. Isoform 2 is expressed at high levels in the dorsal root ganglia, trigeminal ganglia, and throughout the spinal cord with the highest level in the ventral horn.
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Cytoplasm
messages: Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5 (PubMed:9375656). Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin (PubMed:12684468). Interacts with FLNA (By similarity).
messages: Isoform 2 is expressed in growth cones. Up-regulated in motor neurons during axonal regeneration after sciatic nerve lesion. Overexpression of isoform 2 increased neurite extension and branching. Isoform 1 is expressed throughout neurons and their axons.
messages: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.
messages: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
messages: Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.
messages: growth cone

10116:Fam115e
gene id: 10116:Fam115e
uniprot id: Q6P6V7
names: Function
names: Similarity
messages: Belongs to the TCAF family.
messages: May play a role in the regulation of the cation channel TRPM8 activity.

10116:Jmjd8
gene id: 10116:Jmjd8
uniprot id: Q6AY40
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Endoplasmic reticulum lumen
messages: Functions as a positive regulator of TNF-induced NF-kappaB signaling. Regulates angiogenesis and cellular metabolism through interaction with PKM.
messages: N-glycosylated.
messages: Oligomer. Dimer. Interacts with PKM; regulates angiogenesis and metabolism.

10116:Cox7a2l2
gene id: 10116:Cox7a2l2
uniprot id: B2RYS0
uniprot id: P35171
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIa family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with PET100.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

10116:P4ha2
gene id: 10116:P4ha2
uniprot id: A0A8I6ASK1
uniprot id: A6HEG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

10116:Usp26
gene id: 10116:Usp26
uniprot id: A6JMT7
uniprot id: D4A5S1
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

10116:Snx3
gene id: 10116:Snx3
uniprot id: A6K6Y8
uniprot id: Q5U211
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sorting nexin family.
messages: Early endosome
messages: Endosome
messages: Interacts with VPS26A, VPS29 and VPS35; the interaction with VPS35 is direct. The association with the retromer CSC subcomplex subunits is proposed to represent a functional distinct retromer variant described as SNX3-retromer complex. Interacts with USP10 and SCNN1A. Interacts with TRFC. Interacts with SNX8; 2 molecules of SNX8 seems to associate with one molecule of SNX3. Interacts with PTPRU (By similarity). Interacts with MON2 and DOP1B.
messages: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC). May act in part as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes. Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor Tfrc presuambly by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex. Involved in regulation of neurite outgrowth in primary neurons.
messages: The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)).
messages: Ubiquitinated, leading to its proteasomal degradation. Deubiquitinated by USP10 (By similarity).
messages: phagosome

10116:Pdia3
gene id: 10116:Pdia3
uniprot id: P11598
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum lumen
messages: In caput epididymal spermatozoa, detected in the head, mid and principal pieces. In cauda epididymal spermatozoa detected only in the acrosome (at protein level).
messages: Melanosome
messages: Part of the major histocompatibility complex class I (MHC I) peptide loading complex composed of TAP1, TAP2, B2M, MHC heavy chain, TAPBP, PDIA3, and CALR. Interacts with ERP27 and CANX. Interacts with SERPINA2 and with SERPINA1 (By similarity). Interacts with ATP2A2 (By similarity).
messages: Phosphorylated.
messages: Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity.
messages: Seems to be inhibited by acidic phospholipids.
messages: Was originally thought to be a phosphatidyl-inositol 4,5-bisphosphate phosphodiesterase type I (phospholipase C-alpha) then was thought (PubMed:1321829, PubMed:1330685) to be a thiol protease.
messages: Within the major histocompatibility complex class I (MHC I) peptide loading complex forms reversible disulfide-linked heterodimers with TAPBP as part of its protein folding chaperone activity. This is essential to assist the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum.

10116:Vps37d
gene id: 10116:Vps37d
uniprot id: B2GV76
uniprot id: M0RC56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

10116:Crym
gene id: 10116:Crym
uniprot id: Q9QYU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (By similarity).

10116:Mfsd10
gene id: 10116:Mfsd10
uniprot id: D3ZD83
names: Subcellular Location Annotation
messages: Membrane

10116:Rasgrf2
gene id: 10116:Rasgrf2
uniprot id: Q99JE4
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.
messages: Homooligomer and heterooligomer with RASGRF1. Interacts with Ras and RAC1 (By similarity). Interacts in a calcium-dependent manner with calmodulin (By similarity). Interacts with CDK5R1 and probably EPB49. Interacts with the AMPA receptor through GRIA1 (By similarity). Interacts with microtubules (By similarity).
messages: Phosphorylated by CDK5; down-regulates RASGRF2-mediated RAC1 activation.
messages: The DH (DBL-homology) domain mediates interaction with RASGRF1 and EPB49 and is required for RAC1 activation.
messages: The IQ domain mediates the calcium-dependent interaction with calmodulin but is dispensable for the Ras-GEF activity.
messages: The Ras-GEF domain and the N-terminal Ras-GEF domain form a Ras-binding site and mediate Ras activation.
messages: Ubiquitinated upon interaction with Ras. Ubiquitination leads to degradation through the 26S proteasome (By similarity).
messages: Widely expressed. Detected in brain, lung, spleen, pancreas, kidney, liver, heart, mammary gland and skeletal muscle.

10116:Scgb1a1
gene id: 10116:Scgb1a1
uniprot id: A6HZZ1
uniprot id: P17559
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Antiparallel homodimer; disulfide-linked (PubMed:1560460). Interaction with LMBR1L is controversial (By similarity).
messages: Belongs to the secretoglobin family.
messages: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
messages: By glucocorticoids.
messages: Club cells (nonciliated cells of the surface epithelium of the pulmonary airways).
messages: Secreted

10116:Or52a20
gene id: 10116:Or52a20
uniprot id: D3ZKU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Klri2
gene id: 10116:Klri2
uniprot id: Q5DT37
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in natural killer (NK) cells.
messages: Heterodimer with KLRE1.
messages: Lectin-like receptor for natural killer (NK) cells. Heterodimer formation with KLRE1 mediates NK cell cytolytic activity.

10116:Cfap418
gene id: 10116:Cfap418
uniprot id: A0A8L2QK72
uniprot id: A6JFS0
uniprot id: Q6AY71
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts (via N-terminus) with FAM161A (via central region); the interaction is direct.
messages: May be involved in photoreceptor outer segment disk morphogenesis (By similarity).
messages: May be involved in photoreceptor outer segment disk morphogenesis.
messages: Photoreceptor inner segment

10116:Adam15
gene id: 10116:Adam15
uniprot id: A0A8I6AF83
uniprot id: A6J6F0
uniprot id: Q9QYV0
names: Caution
names: Cofactor
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain (By similarity).
messages: Binds 1 zinc ion per subunit.
messages: Disintegrin domain binds to integrin alphaV-beta3.
messages: Endomembrane system
messages: In response to sciatic nerve injury.
messages: Interacts with ITAGV-ITGB3 (vitronectin receptor). Interacts with SH3GL2 and SNX9; this interaction occurs preferentially with ADAM15 precursor, rather than the processed form, suggesting it occurs in a secretory pathway compartment prior to the medial Golgi (By similarity). Interacts with ITAG9-ITGB1. Interacts specifically with Src family protein-tyrosine kinases (PTKs). Interacts with SH3PXD2A. Interacts with ITAGV-ITGB1. Interacts with GRB2, HCK, ITSN1, ITSN2, LYN, MAPK1, MAPK3, NCF1, NCK1, nephrocystin, PTK6, SNX33, LCK and SRC (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylation increases association with PTKs.
messages: Predominantly expressed in brain, spinal cord, sciatic nerve and lung. Expressed at lower levels in all other tissues. In the peripheral nervous system, expressed predominantly by Schwann cells. In the central nervous system, preferentially expressed by neuronal cells.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: The cytoplasmic domain is required for SH3GL2- and SNX9-binding.
messages: The precursor is cleaved by a furin endopeptidase.
messages: acrosome
messages: adherens junction
messages: flagellum

10116:Sde2
gene id: 10116:Sde2
uniprot id: A6JGH9
uniprot id: Q5BJN8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDE2 family.
messages: Both SDE2-UBL and the mature SDE2 are polyubiquitinated.
messages: Cytoplasm
messages: Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress (By similarity). SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage (By similarity).
messages: Interacts (via PIP-box) with PCNA; the interaction is direct and prevents ultraviolet light induced monoubiquitination of PCNA (By similarity). Interacts with FBL/fibrillarin (By similarity). Interacts with CACTIN (By similarity). Interacts with SF3B1 (By similarity). Interacts with U2AF1 (By similarity).
messages: Nucleus
messages: Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content (By similarity). May recruit CACTIN to the spliceosome (By similarity).
messages: Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor (By similarity). Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 (By similarity).
messages: The PIP-box (PCNA interacting peptide) motif mediates both the interaction with PCNA and cleavage of the SDE2 precursor by a deubiquitinating enzyme.
messages: The SAP domain is necessary for specific binding to DNA.
messages: The propeptide displays a ubiquitin-like fold.
messages: Upon binding to PCNA, the N-terminal UBL (ubiquitin-like) propeptide is cleaved at Gly-77 by an unidentified deubiquitinating enzyme; the resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner.

10116:Kif20a
gene id: 10116:Kif20a
uniprot id: A6J2V3
uniprot id: F7F7A1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

10116:Cenpu
gene id: 10116:Cenpu
uniprot id: A6JPN2
uniprot id: Q4V8G7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CENP-U/AME1 family.
messages: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression (By similarity).
messages: Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts with MLF1 (By similarity).
messages: Cytoplasm
messages: Expressed at high levels in glioblastoma cell lines. Up-regulated in GBM (glioblastoma multiforme) tumors. Significantly increased in both the tumor core as well as the contralateral striatum and cortex in gliomas.
messages: Nucleus
messages: Phosphorylated by PLK1 at Thr-73, creating a self-tethering site that specifically interacts with the polo-box domain of PLK1.
messages: kinetochore

10116:Brinp3
gene id: 10116:Brinp3
uniprot id: A6ICQ2
uniprot id: Q8K1M7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the BRINP family.
messages: Expressed from 11.5 dpc.
messages: Expressed in olfactory bulb, cerebellum and neuronal layers in hippocampus.
messages: Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development (By similarity).
messages: Mitochondrion
messages: Secreted

10116:Fastkd3
gene id: 10116:Fastkd3
uniprot id: Q68FN9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAST kinase family.
messages: Mitochondrion
messages: RAP domain is required for FASTKD3 function in mRNA stability and translation.
messages: Required for normal mitochondrial respiration. Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity.

10116:Smim24
gene id: 10116:Smim24
uniprot id: A6K880
names: Subcellular Location Annotation
messages: Membrane

10116:Agxt2
gene id: 10116:Agxt2
uniprot id: A6KJT6
uniprot id: Q64565
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity).
messages: Homotetramer.
messages: Mitochondrion

10116:Xpa
gene id: 10116:Xpa
uniprot id: A6IJB2
uniprot id: D4A981
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

10116:Qrfpr
gene id: 10116:Qrfpr
uniprot id: A6IHX5
uniprot id: P83858
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Highly expressed in the adrenal gland and at moderate levels in the eye and testis. Expressed widely in the brain with high levels in the hypothalamus and moderate levels in the amygdala, basal forebrain, cortex, medulla oblongata, midbrain and thalamus.
messages: Membrane
messages: Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.

10116:Glp1r
gene id: 10116:Glp1r
uniprot id: P32301
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:1326760, PubMed:7813606). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:1326760, PubMed:7813606). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).
messages: May form homodimers and heterodimers with GIPR.
messages: N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
messages: Pancreatic islets, stomach, lung, rat insulinoma cell line.

10116:Gpat3
gene id: 10116:Gpat3
uniprot id: Q4V8J4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone. Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Protects cells against lipotoxicity.
messages: Endoplasmic reticulum membrane
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

10116:Ntrk1
gene id: 10116:Ntrk1
uniprot id: A6J617
uniprot id: P35739
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Homodimerization is induced by binding of a NGF dimer (By similarity). Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a nerve growth factor (NGF)-dependent manner (PubMed:17724123). Interacts with RAPGEF2; the interaction is strengthened after NGF stimulation (PubMed:17724123). Interacts with SQSTM1; bridges NTRK1 to NGFR. Forms a ternary complex with NGFR and KIDINS220; this complex is affected by the expression levels of KIDINS220 and an increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts (phosphorylated upon activation by NGF) with SHC1; mediates SHC1 phosphorylation and activation. Interacts (phosphorylated upon activation by NGF) with PLCG1; mediates PLCG1 phosphorylation and activation. Interacts (phosphorylated) with SH2B1 and SH2B2. Interacts with GRB2. Interacts with PIK3R1. Interacts with FRS2. Interacts with SORT1; may regulate NTRK1 anterograde axonal transport. Interacts with SH2D1A; regulates NTRK1. Interacts with NRADD (PubMed:18624909). Interacts with RAB7A (PubMed:16306406). Interacts with PTPRS (PubMed:17967490). Interacts with USP36; USP36 does not deubiquitinate NTRK1 (By similarity). Interacts with GGA3 (PubMed:26446845).
messages: Isoform Trka-II is primarily expressed in neuronal cells; isoform Trka-I is found in non-neuronal tissues.
messages: Late endosome membrane
messages: Ligand-mediated autophosphorylation. Interaction with SQSTM1 is phosphotyrosine-dependent. Autophosphorylation at Tyr-499 mediates interaction and phosphorylation of SHC1.
messages: Membrane
messages: N-glycosylated.
messages: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1312719, PubMed:1850821). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.
messages: Recycling endosome membrane
messages: The extracellular domain mediates interaction with NGFR.
messages: The pro-survival signaling effect of NTRK1 in neurons requires its endocytosis into signaling early endosomes and its retrograde axonal transport. This is regulated by different proteins including CFL1, RAC1 and SORT1. NTF3 is unable to induce this signaling probably due to the lability of the NTF3-NTRK1 complex in endosomes (By similarity). SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades. Regulated by NGFR (By similarity).
messages: The transmembrane domain mediates interaction with KIDINS220.
messages: Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination by NEDD4L leads to degradation (By similarity). Ubiquitination regulates the internalization of the receptor (By similarity).

10116:Carhsp1
gene id: 10116:Carhsp1
uniprot id: Q9WU49
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds mRNA and regulates the stability of target mRNA.
messages: Can be phosphorylated by DYRK2 (in vitro) (By similarity). Dephosphorylated by calcineurin in a Ca(2+) dependent manner, and probably by PP2A or PP4 serine phosphatases in cAMP- and PKC-mediated pathways.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Homodimer. Interacts with STYX (By similarity).
messages: P-body
messages: Widely expressed.

10116:Cdc20
gene id: 10116:Cdc20
uniprot id: A6JZI4
uniprot id: Q62623
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylated at Lys-66 by SIRT2; deacetylation enhances the interaction of CDC20 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C) (By similarity).
messages: Belongs to the WD repeat CDC20/Fizzy family.
messages: Component of a complex with CDC20, CDC27, SPATC1 and TUBG1 (By similarity). Interacts with NEUROD2 (By similarity). Interacts with dimeric MAD2L1 in its closed conformation form (By similarity). Interacts with BUB1B (By similarity). The phosphorylated form interacts with APC/C (By similarity). Interacts with NINL (By similarity). May interact with MAD2L2 (By similarity). Interacts with CDK5RAP2 (By similarity). Interacts with SIRT2 (By similarity). Interacts with isoform 1 of NEK2 (By similarity). Interacts with HSF1 (via phosphorylated form); this interaction occurs in mitosis in a MAD2L1-dependent manner and prevents PLK1-stimulated degradation of HSF1 by blocking the recruitment of the SCF(BTRC) ubiquitin ligase complex (By similarity). Interacts (via the N-terminal substrate-binding domain) with FBXO5 (By similarity). Interacts with CCNF (By similarity).
messages: Dephosphorylated by CTDP1.
messages: Involved in the metaphase/anaphase transition of cell cycle (By similarity). Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity).
messages: Phosphorylated during mitosis (By similarity). Phosphorylated by BUB1 at Ser-41; Ser-72; Ser-92; Ser-153; Thr-157 and Ser-161 (By similarity). Phosphorylated by NEK2 (By similarity).
messages: Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint. Ubiquitinated at Lys-490 during prometaphase. Ubiquitination at Lys-485 and Lys-490 has no effect on its ability to bind the APC/C complex (By similarity).
messages: centrosome
messages: kinetochore
messages: spindle pole

10116:Septin5
gene id: 10116:Septin5
uniprot id: A6JSF4
uniprot id: D3ZDH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

10116:Rpl37l1
gene id: 10116:Rpl37l1
uniprot id: A6KGD7
uniprot id: P61928
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Differs from that shown extensively.

10116:Snap47
gene id: 10116:Snap47
uniprot id: Q6P6S0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the BLOC-1 complex. Interacts with BLOC1S6. Forms a complex containing SNAP47, VAMP2 and STX1A (By similarity).
messages: Belongs to the SVAP1 family.
messages: Endomembrane system
messages: May play a role in intracellular membrane fusion.
messages: perinuclear region

10116:Cyb5r1
gene id: 10116:Cyb5r1
uniprot id: Q5EB81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Membrane
messages: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.

10116:Rbm20
gene id: 10116:Rbm20
uniprot id: E9PT37
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Associates with components of the U1 and U2 U1 small nuclear ribonucleoprotein complexes.
messages: Cytoplasmic ribonucleoprotein granule
messages: Heterozygous or homozygous adults display left ventricular dilatation (PubMed:22466703, PubMed:24367651). Left ventricular diastolic diameters are significantly larger, although there is no differences in the systolic ventricular dimensions or contractility indices (PubMed:22466703). Subendocardial fibrosis increases with age and was accompanied by electrical abnormalities, such as widening of the QRS complex, atrioventricular conduction delay and a predisposition to arrhythmia (PubMed:22466703). Rats are at risk of sudden death caused by heart failure (PubMed:22466703, PubMed:24367651).
messages: Nucleus
messages: Phosphorylation regulates the subcellular localization. Phosphorylation of Ser-638 and Ser-640 in the RS (arginine/serine-rich) region promotes nuclear localization of the protein (PubMed:35394688). In contrast, phosphorylation of the C-terminal disordered region promotes localization to cytoplasmic ribonucleoprotein granules (By similarity).
messages: RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:23307558, PubMed:24367651, PubMed:24960161, PubMed:25573899, PubMed:27289039, PubMed:33805770, PubMed:35394688). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:23307558, PubMed:24367651, PubMed:24960161, PubMed:25573899). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:23307558, PubMed:24367651, PubMed:24960161, PubMed:25573899, PubMed:33805770, PubMed:35394688). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (By similarity). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (PubMed:27289039).

10116:Lef1
gene id: 10116:Lef1
uniprot id: A0A8I5Y632
uniprot id: A0A8I6A132
uniprot id: A0A8I6GLH5
uniprot id: A6HVS3
uniprot id: A6HVS5
uniprot id: Q9QXN1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCF/LEF family.
messages: Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with TLE1, PIASG, ALYREF/THOC4, EP300, MDFI and MDFIC (By similarity). Interacts with DAZAP2 (By similarity).
messages: Nucleus
messages: Phosphorylated at Thr-153 and/or Ser-164 by NLK (By similarity). Phosphorylation by NLK at these sites represses LEF1-mediated transcriptional activation of target genes of the canonical Wnt signaling pathway (By similarity).
messages: Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors.
messages: Transcription factor that binds DNA in a sequence-specific manner (By similarity). Participates in the Wnt signaling pathway (By similarity). Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity). PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (By similarity). Regulates T-cell receptor alpha enhancer function (By similarity). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). May play a role in hair cell differentiation and follicle morphogenesis (By similarity).

10116:S100a9
gene id: 10116:S100a9
uniprot id: P50116
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the S-100 family.
messages: Cell membrane
messages: Cytoplasm
messages: Highly expressed at sites of inflammation.
messages: Homodimer. Preferentially exists as a heterodimer or heterotetramer with S100A8 known as calprotectin (S100A8/A9) (By similarity). S100A9 interacts with ATP2A2 (By similarity). S100A9 interacts with AGER, and with the heterodimeric complex formed by TLR4 and LY96 in the presence of calcium and/or zinc ions. S100A9 binds quinoline-3-carboxamides in the presence of calcium and/or zinc ions. S100A9 interacts with amyloid-beta protein 40. Calprotectin (S100A8/9) interacts with CEACAM3 and tubulin filaments in a calcium-dependent manner. Heterotetrameric calprotectin (S100A8/A9) interacts with ANXA6 and associates with tubulin filaments in activated monocytes. Calprotectin (S100A8/9) interacts with NCF2/P67PHOX, RAC1, RAC2, CYBA and CYBB. Calprotectin (S100A8/9) interacts with NOS2 to form the iNOS-S100A8/A9 transnitrosylase complex; induced by LDL(ox) (By similarity).
messages: Methylation at His-107 by METTL9 reduces zinc-binding without affecting heterodimerization with S100A8.
messages: Phosphorylated. Phosphorylation inhibits activation of tubulin polymerization.
messages: S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response (PubMed:15153104, PubMed:21487906). It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism (By similarity). Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions (By similarity). The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase (By similarity). Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX (By similarity). The extracellular functions involve pro-inflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities (PubMed:21487906). Its pro-inflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration (By similarity). Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER) (By similarity). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the pro-inflammatory cascade (By similarity). Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth (B…
messages: Secreted
messages: cytoskeleton

10116:Nmnat3
gene id: 10116:Nmnat3
uniprot id: A6I2B1
uniprot id: F7F588
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

10116:Dio1
gene id: 10116:Dio1
uniprot id: P24389
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the iodothyronine deiodinase family.
messages: Endoplasmic reticulum membrane
messages: Highly expressed in the liver, kidney and thyroid gland of adult rats.
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).

10116:Nelfe
gene id: 10116:Nelfe
uniprot id: Q6AXP2
uniprot id: Q6MG75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NELF-E family.
messages: Chromosome
messages: Nucleus

10116:Aurkc
gene id: 10116:Aurkc
uniprot id: A0A8I6GHC0
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

10116:Plscr1
gene id: 10116:Plscr1
uniprot id: A6I238
uniprot id: P58195
uniprot id: Q5U351
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholipid scramblase family.
messages: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific distribution of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface (By similarity). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (By similarity). Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (By similarity). Negatively regulates FcR-mediated phagocytosis in differentiated macrophages (By similarity). May contribute to cytokine-regulated cell proliferation and differentiation (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Forms homooligomers in the presence of calcium (By similarity). Interacts with ABL (By similarity). Interacts with RELT, RELL1 and RELL2 (By similarity). Interacts with OXSR1 in the presence of RELT (By similarity). Interacts with OCLN, TOP2A and TOP2B (By similarity). Interacts with TRPC1, TRPC4 and TRPC5 (By similarity). Interacts with ILDR1 (By similarity).
messages: Magnesium. Can also use zinc with lower efficiency.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
messages: Nucleus
messages: Palmitoylation is required for its phospholipid scramblase activity (By similarity). Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus (By similarity).
messages: Phosphorylated on tyrosine residues (PubMed:11259432). Phosphorylated by OXSR1 in the presence of RELT (By similarity). Phosphorylation at Thr-178 by PKC/PKCD increases its phospholipid scramblase activity during both cell stimulation and apoptosis (By similarity).
messages: The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
messages: The transmembrane domain is essential for membrane insertion, phospholipid scramblase activity and proper calcium-binding.
messages: perinuclear region

10116:Or1e35b
gene id: 10116:Or1e35b
uniprot id: A0A096P6M5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Trim6
gene id: 10116:Trim6
uniprot id: D4A3L4
names: Subcellular Location Annotation
messages: Cytoplasm

10116:Mrps17
gene id: 10116:Mrps17
uniprot id: A6J0Q4
uniprot id: D3ZTR1
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

10116:Slc13a3
gene id: 10116:Slc13a3
uniprot id: A2VD10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

10116:Dmap1
gene id: 10116:Dmap1
uniprot id: F7FQE3
uniprot id: Q568Y6
names: Subcellular Location Annotation
messages: Nucleus

10116:Gdf15
gene id: 10116:Gdf15
uniprot id: Q9Z0J6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TGF-beta family.
messages: Detected in plasma (at protein level).
messages: Expression is up-regulated by obesity.
messages: Homodimer; disulfide-linked (By similarity). Interacts with GFRAL; ligand of GFRAL which mediates GDF15 internalization and cellular signaling through interaction with RET (By similarity).
messages: Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (Probable). On hepatocytes, inhibits growth hormone signaling (By similarity).
messages: Secreted

10116:Gpld1
gene id: 10116:Gpld1
uniprot id: A6KLE5
uniprot id: G3V8B1
uniprot id: Q8R2H5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPLD1 family.
messages: Glycosylated.
messages: Monomer.
messages: Secreted
messages: This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.

10116:Gtf2ird1
gene id: 10116:Gtf2ird1
uniprot id: A0A0G2JVV8
uniprot id: A6J0J2
uniprot id: A6J0J3
uniprot id: Q78ZG1
names: Subcellular Location Annotation
messages: Nucleus

10116:Or14p1
gene id: 10116:Or14p1
uniprot id: A6KQF6
uniprot id: D4ACW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Supv3l1
gene id: 10116:Supv3l1
uniprot id: Q5EBA1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family.
messages: Helicase activity toward DNA substrate is inhibited by micromolar concentrations of 5,6-dichloro-1-(beta-D-ribofuranosyl)benzotriazole (DRBT) and 4,5,6,7-tetrabromobenzotriazole (TBBT). Helicase activity toward RNA substrate is inhibited by elevated concentrations of TBBT. Inhibited by some ring-expanded nucleoside analogs.
messages: Homodimer; in free form. Component of the mitochondrial degradosome (mtEXO) complex which is a heteropentamer containing 2 copies of SUPV3L1 and 3 copies of PNPT1. As part of mitochondrial degradosome complex, interacts with GRSF1 in a RNA-dependent manner; the interaction enhances the activity of the complex. Interacts with LAMTOR5/HBXIP, WRN and BLM.
messages: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.
messages: Mitochondrion matrix
messages: Nucleus
messages: mitochondrion nucleoid

10116:Spata18
gene id: 10116:Spata18
uniprot id: Q6AYL6
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Expressed at late stages of spermatogenesis, from late to maturing spermatids.
messages: High expressed in testis and weakly expressed in lung, intestine, and spleen. Not expressed in spermatogonia, spermatocytes, and round spematids in adult testis but specifically detected in elongated spermatids.
messages: Interacts (via coiled-coil domains) with BNIP3L (via BH3 domain). Interacts (via coiled-coil domains) with BNIP3 (via BH3 domain). Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane.
messages: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). May have a role in spermatogenesis, especially in cell differentiation from late elongate spermatids to mature spermatozoa.
messages: Mitochondrion outer membrane

10116:Or10aa3
gene id: 10116:Or10aa3
uniprot id: D3ZIK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Crygs
gene id: 10116:Crygs
uniprot id: A6JS55
uniprot id: P0C5E9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Monomer.

10116:Chkb
gene id: 10116:Chkb
uniprot id: O54783
names: Function
names: Similarity
names: Subunit
messages: Belongs to the choline/ethanolamine kinase family.
messages: Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis.
messages: Homodimer, and heterodimer with CHKA.

10116:Hoxc13
gene id: 10116:Hoxc13
uniprot id: D3ZKV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

10116:Anapc2
gene id: 10116:Anapc2
uniprot id: B2RYJ1
names: Similarity
messages: Belongs to the cullin family.

10116:Olr1340
gene id: 10116:Olr1340
uniprot id: A6J3P6
uniprot id: F1LWN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Kcna10
gene id: 10116:Kcna10
uniprot id: D3ZRW4
names: Subcellular Location Annotation
messages: Membrane

10116:Ppa1
gene id: 10116:Ppa1
uniprot id: Q499R7
names: Similarity
messages: Belongs to the PPase family.

10116:Slc8a1
gene id: 10116:Slc8a1
uniprot id: A0A8L2QK59
uniprot id: A0A8L2QNY8
uniprot id: A6H9N8
uniprot id: A6H9P0
uniprot id: A6H9P2
uniprot id: A6H9P3
uniprot id: A6H9P6
uniprot id: Q01728
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by micromolar levels of Ca(2+) (PubMed:12502557).
messages: Active at all calcium levels tested (PubMed:15040000). Activated by PKC (PubMed:15040000).
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Detected in heart, brain cortex and hippocampus (at protein level) (PubMed:16914199). Cardiac sarcolemma or brain, and spleen. Expressed in all regions of the kidney, highest levels of expression in the distal convoluted tubule. Expressed throughout the CNS, in decreasing order of abundance in hippocampus, cortex, cerebellum, hypothalamus, midbrain and striatum. Expressed in numerous regions of the brain including multiple cortical layers, hippocampus, septal nuclei, thalamic nuclei, cerebellum, hypothalamus, olfactory bulb and brainstem. Also expressed in various regions of the spinal cord, ventricles and atria of the heart, lung, adrenals and kidney. Isoform 4 seems to be a predominant isoform in aorta, stomach, liver, and kidney.
messages: Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:8422940, PubMed:8454039, PubMed:10894800, PubMed:12502557). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions (By similarity).
messages: Membrane
messages: Only active at low calcium concentrations (PubMed:15040000). Activated by PKC (PubMed:15040000).
messages: Only active at low calcium concentrations (PubMed:15040000). Not activated by PKC (PubMed:15040000).
messages: The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium-regulated ion exchange.
messages: dendrite

10116:Sppl3
gene id: 10116:Sppl3
uniprot id: D3ZY49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

10116:Cebpd
gene id: 10116:Cebpd
uniprot id: A6JSR2
uniprot id: Q03484
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPA, CEBPB and CEBPE. Directly interacts with SPI1/PU.1; this interaction does not affect DNA-binding properties of each partner. Interacts with PRDM16.
messages: Nucleus
messages: Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:1714459). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (By similarity).
messages: Ubiquitously expressed.

10116:Gab2
gene id: 10116:Gab2
uniprot id: Q9EQH1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis (By similarity).
messages: Belongs to the GAB family.
messages: Cell membrane
messages: Cytoplasm
messages: Dephosphorylated by PTPN11.
messages: Membrane raft
messages: Part of a complex composed of EEIG1, TNFRSF11A/RANK, PLCG2, GAB2, TEC and BTK; complex formation increases in the presence of TNFSF11/RANKL (By similarity). Interacts with HCK. Interacts with SHC1; may mediate interaction with receptors (By similarity). Interacts with SYK (By similarity). Interacts with PI-3 kinase (By similarity). Interacts with GRB2 (via SH3 2 domain) (By similarity). Interacts (phosphorylated) with PTPN11 (By similarity). Interacts with TNFRSF11A (via cytoplasmic domain) (By similarity). Interacts (phosphorylated) with 14-3-3 family proteins SFN, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ; prevents interaction with GRB2 and attenuates GAB2 signaling (By similarity).
messages: Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling (By similarity). Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R (By similarity). Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL (By similarity).
messages: The PH domain mediates phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate binding.
messages: The SH3-binding motifs mediate interaction with SHC1 and GRB2.

10116:Stk32c
gene id: 10116:Stk32c
uniprot id: A6HXA9
names: Similarity
messages: Belongs to the protein kinase superfamily.

10116:Olr1869
gene id: 10116:Olr1869
uniprot id: Q6ZM99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:RGD1307947
gene id: 10116:RGD1307947
uniprot id: Q6AXM9
names: Function
names: PTM
messages: AMPylates itself (auto-AMPylation).
messages: Functions as an RNA ligase, in vitro. The ligation reaction entails three nucleotidyl transfer steps. In the first step, the RNA ligase reacts with ATP in the absence of nucleic acid to form a covalent ligase-AMP intermediate and release pyrophosphate. In step 2, the ligase-AMP binds to the nucleic acid and transfers the adenylate to the 5'-PO4 terminus to form an adenylylated intermediate. In step 3, the RNA ligase directs the attack of the 3'-OH on the 5'-phosphoanhydride linkage, resulting in a repaired 3'-5' phosphodiester and release of AMP. Exhibits selectivity for single-stranded RNA substrates and may not have nick-sealing activity on double-stranded DNA-RNA hybrids. May play a role in maintaining RNA integrity under stress conditions, for example in response to reactive oxygen species (ROS).

10116:Dcxr
gene id: 10116:Dcxr
uniprot id: Q920P0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
messages: Highly expressed in kidney and liver. Weakly or not expressed in brain, heart, lung, spleen, epididymis and testis.
messages: Homotetramer.
messages: Membrane

10116:Csprs
gene id: 10116:Csprs
uniprot id: F1M529
names: Subcellular Location Annotation
messages: Membrane

10116:Lipt1
gene id: 10116:Lipt1
uniprot id: A0A8I5ZRJ8
uniprot id: A6INI4
uniprot id: D3Z7Z4
names: Similarity
messages: Belongs to the LplA family.

10116:Or4f7
gene id: 10116:Or4f7
uniprot id: D3ZYZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ldb3
gene id: 10116:Ldb3
uniprot id: A0A0G2JXR0
uniprot id: A0A0G2K2C4
uniprot id: Q5XIG1
names: Subcellular Location Annotation
messages: Z line

10116:Kcnd3
gene id: 10116:Kcnd3
uniprot id: A0A0G2JSN5
uniprot id: A0A0G2JSW5
uniprot id: Q62897
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily.
messages: Cell membrane
messages: Highly expressed in brain, in particular in the retrosplenial cortex, medial habenula, anterior thalamus, hippocampus, cerebellum and lateral geniculate and superior colliculus. Highly expressed in heart atrium (at protein level) and throughout the ventricle wall, in lung and vas deferens.
messages: Homotetramer or heterotetramer with KCND1 and/or KCND2. Interacts with DLG1. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Interacts with KCNE1, KCNE2, SCN1B and KCNAB1 (By similarity).
messages: Membrane
messages: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
messages: Regulated through phosphorylation at Ser-569 by CaMK2D.
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
messages: dendrite
messages: sarcolemma

10116:Ldc1
gene id: 10116:Ldc1
uniprot id: F1LVE6
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

10116:Zeb2
gene id: 10116:Zeb2
uniprot id: A0A0G2K8T6
uniprot id: Q3T921
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

10116:Emc9
gene id: 10116:Emc9
uniprot id: A6KH14
uniprot id: Q5U1W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC8/EMC9 family.
messages: Component of the ER membrane protein complex (EMC). EMC8 and EMC9 are mutually exclusive subunits of the EMC complex.
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.

10116:Yme1l1
gene id: 10116:Yme1l1
uniprot id: G3V886
uniprot id: Q66HP7
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

10116:Wnt6
gene id: 10116:Wnt6
uniprot id: A6JVW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

10116:Get1
gene id: 10116:Get1
uniprot id: A6KPR9
uniprot id: Q6P6S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WRB/GET1 family.
messages: Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, CAMLG/GET2 and GET3 (PubMed:23041287). Within the complex, GET1 and CAMLG form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer (By similarity). Interacts with CAMLG/GET2 (via C-terminus) (PubMed:23041287). GET3 shows a higher affinity for CAMLG than for GET1 (By similarity).
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287). Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287). Required to ensure correct topology and ER insertion of CAMLG (By similarity).

10116:Txndc2
gene id: 10116:Txndc2
uniprot id: Q5XHX6
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase (By similarity).
messages: Testis-specific. Strongly expressed in the testicular seminiferous tubules, mostly in the round spermatids.
messages: Transiently expressed in spermiogenesis, being mostly concentrated in the periaxonemal compartment of the tail of the elongating spermatid, where it transiently associates with the longitudinal column of the FS. In the very last steps (steps 17-19), when periaxonemal expression disappears, it is still weakly present in the shrinking cytoplasmic lobe (at protein level).

10116:Hs3st3b1
gene id: 10116:Hs3st3b1
uniprot id: D3ZTA9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

10116:Dym
gene id: 10116:Dym
uniprot id: A0A0H2UHP8
uniprot id: A6KRI0
uniprot id: B4F766
uniprot id: D3ZP27
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dymeclin family.
messages: Cytoplasm
messages: Golgi apparatus
messages: Interacts with GOLM1 and PPIB.
messages: Membrane
messages: Myristoylated in vitro; myristoylation is not essential for protein targeting to Golgi compartment.
messages: Necessary for correct organization of Golgi apparatus. Involved in bone development.

10116:Nkx1-2
gene id: 10116:Nkx1-2
uniprot id: A6HWZ2
uniprot id: D3Z9E2
names: Subcellular Location Annotation
messages: Nucleus

10116:Gng2
gene id: 10116:Gng2
uniprot id: A6KKL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: Membrane

10116:Hsd17b8
gene id: 10116:Hsd17b8
uniprot id: Q6MGB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Expressed in ovary at protein level.
messages: Heterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4.
messages: Mitochondrion matrix
messages: Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex that acts as scaffold protein required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference; this enzymatic activity is not needed for the KAR function. Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+). Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters. NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol (17beta-estradiol or E2). Has very low activity towards testosterone and dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one). Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active 17beta-estradiol.

10116:Ccr6
gene id: 10116:Ccr6
uniprot id: A0A8I5ZP26
uniprot id: Q5BK58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

10116:Rpl6
gene id: 10116:Rpl6
uniprot id: A6J1G1
uniprot id: P21533
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL6 family.
messages: Component of the large ribosomal subunit (By similarity). May bind IPO9 with low affinity (By similarity).
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

10116:Rhob
gene id: 10116:Rhob
uniprot id: P62747
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Binds ROCK1 and ROCK2 (PubMed:8816443). Also binds PKN1/PRK1. Interacts with ARGGEF3. Interacts with RTKN. Interacts with AKAP13. Interacts with RIPOR1 (By similarity).
messages: Cell membrane
messages: Cleavage furrow
messages: Expressed at very low levels in quiescent cells but is transiently induced by serum stimulation with levels increasing to a maximum within 30 minutes and declining over the next hour.
messages: Late endosome membrane
messages: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells (By similarity).
messages: Nucleus
messages: Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome (By similarity).

10116:Snrpa1
gene id: 10116:Snrpa1
uniprot id: D3ZLF6
uniprot id: D3ZZR5
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

10116:Gna15
gene id: 10116:Gna15
uniprot id: O88302
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

10116:Or51g2
gene id: 10116:Or51g2
uniprot id: A6I778
uniprot id: F1LWZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Gpc3
gene id: 10116:Gpc3
uniprot id: P13265
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (By similarity). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity).
messages: Cleaved intracellularly by a furin-like convertase to generate 2 subunits, alpha and beta, which remain associated through disulfide bonds and are associated with the cell surface via the GPI-anchor. This processing is essential for its role in inhibition of hedgehog signaling. A second proteolytic event may result in cleavage of the protein on the cell surface, separating it from the GPI-anchor and leading to its shedding from the cell surface.
messages: Heterodimer; disulfide-linked (By similarity). Cleavage by a furin-like convertase results in production of alpha and beta chains which form a disulfide-linked heterodimer (By similarity). Interacts with DPP4 (By similarity). Interacts with FGF2 (PubMed:9065409). Interacts with WNT5A (By similarity). Also interacts with WNT3A and WNT7B (By similarity). Interacts with hedgehog protein SHH; the heparan sulfate chains are not required for the interaction (By similarity). Also interacts with hedgehog protein IHH (By similarity). Interacts with CD81 (By similarity). Interacts with Wnt receptors FZD4, FZD7 and FZD8; the heparan sulfate chains are required for the interaction (By similarity).
messages: In the intestine, expression decreases gradually from 20 dpc and finally becomes undetectable after weaning around 24 days after birth.
messages: O-glycosylated; contains heparan sulfate and/or chondroitin sulfate.

10116:Chst1
gene id: 10116:Chst1
uniprot id: A6HNH9
uniprot id: Q5RJQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of internal galactose (Gal) residues of keratan. Cooperates with B4GALT4 and B3GNT7 glycosyltransferases and CHST6 sulfotransferase to construct and elongate disulfated disaccharide unit [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer (By similarity). Involved in biosynthesis of phosphacan, a major keratan sulfate proteoglycan in the developing brain (By similarity). Involved in biosynthesis of 6-sulfoGalbeta-containing O-linked glycans in high endothelial venules of lymph nodes. May act in a synergistic manner with CHST4 to generate sialyl 6',6-disulfo Lewis X motif, a recognition determinant for immune cell receptors implicated in leukocyte trafficking (By similarity). Catalyzes sulfation of N-acetyllactosamine (LacNAc) oligosaccharides with highest efficiency for sialylated LacNAc structures (By similarity).

10116:Lepr
gene id: 10116:Lepr
uniprot id: Q62959
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis.
messages: Basolateral cell membrane
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Cell membrane
messages: Isoform B is expressed in kidney, liver, lung, ovary, spleen and uterus. Increased level in uterus during gestation (PubMed:8772180). Isoform A and isoform C are predominantly expressed in cerebral microvessels and choroid plexus, with lower levels in cortex, cerebellum and hypothalamus but also liver and lung (PubMed:11861497). Isoform F is expressed at high levels in brain, liver and spleen and less in stomach, kidney, thymus, heart, lung and hypothalamus (PubMed:11861497, PubMed:8772180).
messages: May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis (PubMed:10698121). Does not induce phosphorylation of and activate STAT3 (By similarity).
messages: On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-985 is required for complete binding and activation of PTPN11, ERK/FOS activation,for interaction with SOCS3 and SOCS3 mediated inhibition of leptin signaling. Phosphorylation on Tyr-1138 is required for STAT3 binding/activation. Phosphorylation of Tyr-1077 has a more accessory role.
messages: Present as a mixture of monomers and dimers (Probable). The phosphorylated receptor binds a number of SH2 domain-containing proteins such as JAK2, STAT3, PTPN11, and SOCS3 (By similarity). Interaction with SOCS3 inhibits JAK/STAT signaling and MAPK cascade (By similarity).
messages: Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (PubMed:8690163). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (By similarity). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity).
messages: Secreted
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: The fatty (Fa) mutation produces profound obesity of early onset caused by hyperphagia, defective non-shivering thermogenesis, and preferential deposition of energy into adipose tissue.

10116:Acap1
gene id: 10116:Acap1
uniprot id: D4ABD3
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

10116:Pbx3
gene id: 10116:Pbx3
uniprot id: A0A8I6AGR6
uniprot id: A6JUC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

10116:Rbm8a
gene id: 10116:Rbm8a
uniprot id: A6K380
uniprot id: Q27W01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Heterodimer with either MAGOH or MAGOHB. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH or MAGOHB, and RBM8A. Interacts with PYM1; the interaction is direct and dissociates the EJC from spliced mRNAs. Part of a complex that contains the EJC core components CASC3, EIF4A3, MAGOH and RBM8A plus proteins involved in nonsense-mediated mRNA decay, such as UPF1, UPF2, UPF3A and UPF3B. Found in a post-splicing complex with NXF1, MAGOH, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Interacts with DDX39B, MAGOH, DPH1, UPF3B, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with IPO13; the interaction mediates the nuclear import of the MAGOH-RBM8A heterodimer. Identified in the spliceosome C complex. Associates with polysomes.
messages: Nucleus
messages: Nucleus speckle
messages: Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs (By similarity).

10116:Homer2
gene id: 10116:Homer2
uniprot id: A6JCH3
uniprot id: O88801
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Homer family.
messages: Cell membrane
messages: Constitutively expressed in the adult hippocampus.
messages: Cytoplasm
messages: In the developing hippocampus, expression is high at P8, then decreased along with hippocampal development.
messages: Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization. Interacts with NFATC2; interaction is reduced by AKT activation. Interacts with NFATC1 and NFATC4 (By similarity). Interacts with DAGLA (via PPXXF motif); this interaction is required for the cell membrane localization of DAGLA (Probable).
messages: Postsynaptic density
messages: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Required for normal hearing (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity).
messages: Synapse
messages: The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.
messages: stereocilium

10116:Or4p19
gene id: 10116:Or4p19
uniprot id: A0A8I6G3E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tcf25
gene id: 10116:Tcf25
uniprot id: A6IZX9
uniprot id: D3ZC46
names: Similarity
messages: Belongs to the TCF25 family.

10116:Xrcc5
gene id: 10116:Xrcc5
uniprot id: Q6P7P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase.

10116:Prnd
gene id: 10116:Prnd
uniprot id: A0A8I6A8S4
uniprot id: A7U7N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Membrane

10116:Sptlc1
gene id: 10116:Sptlc1
uniprot id: D4A2H2
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Component of the serine palmitoyltransferase (SPT) complex, which is also composed of SPTLC2 or SPTLC3 and SPTSSA or SPTSSB (By similarity). The heterodimer with SPTLC2 or SPTLC3 forms the catalytic core of the enzyme, while SPTSSA or SPTSSB subunits determine substrate specificity (By similarity). SPT also interacts with ORMDL proteins, especially ORMDL3, which negatively regulate SPT activity in the presence of ceramides (By similarity). Forms dimers of heterodimers with SPTLC2 (By similarity). Interacts with RTN4 (isoform B) (By similarity).
messages: Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is also composed of SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer with SPTLC2 or SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity). Required for adipocyte cell viability and metabolic homeostasis (By similarity).
messages: Endoplasmic reticulum membrane
messages: Expressed in astrocytes.
messages: Expression in increased by palmitate at the protein level, but not at the mRNA level (PubMed:21994399). Expression is down-regulated by microRNA miR-137 and miR-181c (at protein level) (PubMed:21994399).
messages: Phosphorylation at Tyr-164 inhibits activity and promotes cell survival.
messages: SPT complex catalytic activity is negatively regulated by ORMDL proteins, including ORMDL3, in the presence of ceramides (By similarity). This mechanism allows to maintain ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (Probable).
messages: The transmembrane domain is involved in the interaction with ORMDL3.

10116:Rdh7
gene id: 10116:Rdh7
uniprot id: A6HQX7
uniprot id: P55006
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on retinol bound on cellular retinol-binding protein (CRBP).
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Endoplasmic reticulum
messages: Microsome

10116:Taar2
gene id: 10116:Taar2
uniprot id: Q5QD25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Orphan receptor.

10116:Eno1
gene id: 10116:Eno1
uniprot id: A0A8I6ART9
uniprot id: A0A9K3Y892
uniprot id: P04764
uniprot id: Q5BJ93
names: Cofactor
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the enolase family.
messages: Binds two Mg(2+) per subunit. Required for catalysis and for stabilizing the dimer.
messages: Cell membrane
messages: Cytoplasm
messages: During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells. In brain, levels of ENO1 decrease around 10 dpc and then gradually increase to adult age. In embryonic heart, ENO1 levels decrease rapidly during cardiac development.
messages: Expressed in flagella of epididymal sperm. The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.
messages: Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.
messages: ISGylated.
messages: Lysine 2-hydroxyisobutyrylation (Khib) by p300/EP300 activates the phosphopyruvate hydratase activity.
messages: Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific (By similarity). ENO1 interacts with PLG in the neuronal plasma membrane and promotes its activation. The C-terminal lysine is required for this binding (PubMed:7964722). Interacts with ENO4 and PGAM2 (By similarity). Interacts with CMTM6 (By similarity).

10116:Man1a2
gene id: 10116:Man1a2
uniprot id: A6K3G6
uniprot id: D3ZR49
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

10116:Cdh3
gene id: 10116:Cdh3
uniprot id: A6IYX2
uniprot id: F1LMI3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

10116:Plxna2
gene id: 10116:Plxna2
uniprot id: D3ZWP6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Kcnc3
gene id: 10116:Kcnc3
uniprot id: Q811T3
names: Subcellular Location Annotation
messages: Membrane

10116:Ero1b
gene id: 10116:Ero1b
uniprot id: A0A8I6GLG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

10116:Mars1
gene id: 10116:Mars1
uniprot id: A0A8I5ZKR4
uniprot id: A6HQU9
uniprot id: D3Z941
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

10116:Atp2b4
gene id: 10116:Atp2b4
uniprot id: Q64542
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by calcium/calmodulin.
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (By similarity). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity).
messages: Cell membrane
messages: Interacts with PDZD11. Interacts with SLC35G1 and STIM1. Interacts with calmodulin.
messages: Ubiquitously expressed. Not detected in liver. The highest levels are found in uterus and stomach. Isoform XA is found in uterus, brain, stomach, small intestine, colon and pancreas. Isoform XB is found in uterus, skeletal muscle, lung, kidney, spleen, stomach, small intestine and pancreas. Isoform ZA is found in testis and isoform ZB is found in testis and heart.
messages: flagellum membrane

10116:Zc3h12b
gene id: 10116:Zc3h12b
uniprot id: A6IQ32
uniprot id: D4ACQ4
names: Similarity
messages: Belongs to the ZC3H12 family.

10116:Arrdc1
gene id: 10116:Arrdc1
uniprot id: A6JSZ3
uniprot id: B0BNL6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the arrestin family.
messages: Cell membrane
messages: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles. More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles. By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway.
messages: Interacts (via PPxY motifs) with ITCH (via WW domains); the interaction is direct and participates in the recruitment of the ubiquitin-protein ligase ITCH to the NOTCH1 receptor (By similarity). Interacts with ARRB1 and ARRB2; the interaction is direct (PubMed:23886940). Interacts with TSG101; may recruit TSG101 to the plasma membrane. Interacts (via PPxY motifs) with WWP2 (via WW domains); ubiquitinates ARRDC1. Interacts with SLC11A2; controls the incorporation of SLC11A2 into extracellular vesicles through an ubiquitination-dependent mechanism. Interacts with WWP1 (via WW domains). Interacts with NEDD4 (via WW domains). Interacts with PDCD6IP (By similarity).
messages: The PPxY motifs mediate interaction with WW domain-containing ubiquitin-protein ligases.
messages: Ubiquitinated. Ubiquitination by WWP2; promotes localization to extracellular microvesicles. Ubiquitinated by WWP1.

10116:Clcc1
gene id: 10116:Clcc1
uniprot id: A0A140TAF5
uniprot id: A6HV18
uniprot id: A6HV20
uniprot id: A6HV21
uniprot id: D3ZKI2
uniprot id: Q9WU61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the chloride channel MCLC family.
messages: Endoplasmic reticulum membrane
messages: Expressed in testis (spermatocytes), liver and lung (at protein level). Expressed in spleen, liver, testis, kidney, heart, brain and lung.
messages: Golgi apparatus membrane
messages: Interacts with mitochondrial protein PIGBOS1 (via C-terminus); the interaction occurs at the mitochondria-associated endoplasmic reticulum (ER) membrane, a zone of contact between the ER and mitochondrial membranes, but does not appear to play a role in ER-mitochondria tethering and is not affected by ER stress (By similarity). Interacts with CALR (By similarity).
messages: Membrane
messages: Nucleus membrane
messages: Seems to act as a chloride ion channel (PubMed:11279057). Plays a role in retina development (By similarity).

10116:Irf2bp1
gene id: 10116:Irf2bp1
uniprot id: A6J8I8
uniprot id: D4AAZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

10116:Gpr151
gene id: 10116:Gpr151
uniprot id: A6J3K7
uniprot id: Q7TSN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Exclusively expressed in neurons of the habenular complex. The expression is particularly prominent in the medial habenular nucleus, whereas the lateral habenular nucleus exhibited a lower level of expression.
messages: Membrane
messages: Orphan receptor.

10116:Amhr2
gene id: 10116:Amhr2
uniprot id: A6KCV2
uniprot id: Q62893
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Expressed in the mesenchymal cells surrounding the Muellerian duct at embryonic days 14, 15, and 16 and in tubular and follicular structures of the fetal gonads.
messages: Interacts with type I receptor ACVR1.
messages: Membrane
messages: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

10116:Or5g9
gene id: 10116:Or5g9
uniprot id: A0A0G2K1I3
uniprot id: A6HMU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Mpdu1
gene id: 10116:Mpdu1
uniprot id: A6HFS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane
messages: Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.

10116:Ache
gene id: 10116:Ache
uniprot id: A0A9K3Y822
uniprot id: P37136
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Has been found in central nervous system and muscle (PubMed:8417155). Found in embryonic liver and spleen but not in adult liver (PubMed:8417155).
messages: Homotetramer; composed of disulfide-linked homodimers. Catalytic forms H (GPI-anchor dimer) and T (asymmetric collagen-tailed), which differ in their C-terminus, account for all types of known ACHE forms (Probable). Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers (By similarity).
messages: May be not functional.
messages: Secreted
messages: Synapse
messages: Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.

10116:Prkar1a
gene id: 10116:Prkar1a
uniprot id: A6HKB8
uniprot id: P09456
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane
messages: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
messages: The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP releases the two active catalytic monomers and the regulatory dimer. Interacts with PRKACA and PRKACB (By similarity). PRKAR1A also interacts with RFC2; the complex may be involved in cell survival. Interacts with AKAP4. Interacts with RARA; the interaction occurs in the presence of cAMP or FSH and regulates RARA transcriptional activity. Interacts with the phosphorylated form of PJA2. Interacts with CBFA2T3. Interacts with PRKX; regulates this cAMP-dependent protein kinase (By similarity). Interacts with smAKAP; this interaction may target PRKAR1A to the plasma membrane. Interacts with AICDA (By similarity).
messages: The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.
messages: Two types of regulatory chains are found: type I, which predominates in skeletal muscle, and type II, which predominates in cardiac muscle.

10116:Rpl10
gene id: 10116:Rpl10
uniprot id: A6KRS1
uniprot id: Q6PDV7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Citrullinated by PADI4.
messages: Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
messages: Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.
messages: Cytoplasm
messages: Ufmylated by UFL1.

10116:Limk2
gene id: 10116:Limk2
uniprot id: A6IKA2
uniprot id: P53670
uniprot id: Q5D047
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Binds ROCK1 and MARF1 (By similarity). Interacts with NISCH (By similarity).
messages: Cytoplasm
messages: Found in various tissues at moderate levels, except for testis, which shows very low expression.
messages: Nucleus
messages: Phosphorylated on serine and/or threonine residues by ROCK1.
messages: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP. Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity).
messages: centrosome
messages: perinuclear region
messages: spindle

10116:Ap4b1
gene id: 10116:Ap4b1
uniprot id: A0A8I6A896
uniprot id: A6K3M9
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

10116:Tas2r140
gene id: 10116:Tas2r140
uniprot id: Q67ES0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Putative taste receptor which may play a role in the perception of bitterness.
messages: Several bitter taste receptors are expressed in a single taste receptor cell.

10116:Or4a66
gene id: 10116:Or4a66
uniprot id: M0RCD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Emsy
gene id: 10116:Emsy
uniprot id: A0A8I6AMY7
names: Subcellular Location Annotation
messages: Nucleus

10116:Carm1
gene id: 10116:Carm1
uniprot id: A6JNT0
uniprot id: Q4AE70
names: Activity Regulation
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Auto-methylated on Arg-551. Methylation enhances transcription coactivator activity. Methylation is required for its role in the regulation of pre-mRNA alternative splicing (By similarity).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
messages: Chromosome
messages: Cytoplasm
messages: Expressed in fetal brain.
messages: Homodimer (PubMed:17882262). Interacts with NR1H4 (By similarity). Interacts with SNRPC (PubMed:15944154). Interacts with the C-terminus of NCOA2/GRIP1, NCO3/ACTR and NCOA1/SRC1. Part of a complex consisting of CARM1, EP300/P300 and NCOA2/GRIP1. Interacts with FLII, TP53, myogenic factor MEF2, EP300/P300, TRIM24, CREBBP and CTNNB1. Interacts with RELA. Identified in a complex containing CARM1, TRIM24 and NCOA2/GRIP1. Interacts with NCOA3/SRC3. Interacts with SKP2. Interacts (via PH domain-like fold) with C9orf72 (By similarity). Interacts with PARP1; promoting PARP1 recruimtent to replication forks (By similarity).
messages: Isoform 1 is expressed at low levels in brain, liver and testis.
messages: Isoform 2 is highly expressed in brain, liver, skeletal muscle and testis.
messages: Isoform 3 is highly expressed in spleen, liver and kidney.
messages: Isoform 3 specifically affects pre-mRNA splicing (PubMed:15944154). This activity is independent from methyltransferase activity (PubMed:15944154).
messages: Isoform 4 is expressed in spleen, liver and kidney.
messages: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability (PubMed:16508003). Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activates transcription via chromatin remodeling (By similarity). During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription (By similarity). During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C (By similarity). During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B (By similarity). Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue (By similarity). Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors (By similarity). Also seems to be involved in p53/TP53 transcriptional activation (By similarity). Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation (By similarity). Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs (PubMed:16508003). Acts as a transcriptional coactivator of ACACA/acetyl-CoA carboxylase by enriching H3R17 methylation at its promoter, thereby positively regulating fatty acid synthesis (By similarity). Independently of it…
messages: Methylation of H3R17 (H3R17me) by CARM1 is stimulated by preacetylation of H3 'Lys-18' (H3K18ac) H3 'Lys-23' (H3K23ac) by EP300 and blocked by citrullination of H3 'Arg-17' (H3R17ci) by PADI4.
messages: Nucleus
messages: Phosphorylation at Ser-217 interferes with S-adenosyl-L-methionine binding and strongly reduces methyltransferase activity. Phosphorylation at Ser-217 is strongly increased during mitosis, and decreases rapidly to a very low, basal level after entry into the G1 phase of the cell cycle. Phosphorylation at Ser-217 may promote location in the cytosol (By similarity).
messages: Ubiquitinated by E3 ubiquitin-protein ligase complex containing FBXO9 at Lys-228; leading to proteasomal degradation.

10116:Inmt
gene id: 10116:Inmt
uniprot id: A6K0X3
uniprot id: D3ZNJ5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

10116:Sfswap
gene id: 10116:Sfswap
uniprot id: D3ZTQ1
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors (By similarity). Represses the splicing of MAPT/Tau exon 10.

10116:Kif22
gene id: 10116:Kif22
uniprot id: A6I9K6
uniprot id: Q5I0E8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Interacts with FAM83D and SIAH1.
messages: Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.
messages: Nucleus
messages: Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
messages: cytoskeleton

10116:Rps18l1
gene id: 10116:Rps18l1
uniprot id: A6JJH6
uniprot id: P62271
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the small ribosomal subunit.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

10116:Cbfa2t2
gene id: 10116:Cbfa2t2
uniprot id: A0A8I5ZYV9
names: Similarity
messages: Belongs to the CBFA2T family.

10116:Tmprss2
gene id: 10116:Tmprss2
uniprot id: F7EQ71
uniprot id: Q6P7D7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Syne1
gene id: 10116:Syne1
uniprot id: A0A8I6B1X1
names: Similarity
messages: Belongs to the nesprin family.

10116:Cadm3
gene id: 10116:Cadm3
uniprot id: Q1WIM3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nectin family.
messages: Cell junction
messages: Cell membrane
messages: Homodimer. Can form trans-heterodimers with NECTIN3. Interacts with EPB41L1, DLG3, PALS2 and CASK (By similarity).
messages: Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).
messages: The cytoplasmic region mediates interaction with EPB41L1, DLG3, PALS2 and CASK.

10116:RGD1359108
gene id: 10116:RGD1359108
uniprot id: Q66HC3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and modulating its protein kinase activity. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (By similarity). Positively regulates initiation of autophagy by regulating the RAB1A-dependent trafficking of the ULK1/ATG1 kinase complex to the phagophore which leads to autophagosome formation. Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates. Plays a role in endosomal trafficking. May be involved in regulating the maturation of phagosomes to lysosomes. Promotes the lysosomal localization and lysosome-mediated degradation of CARM1 which leads to inhibition of starvation-induced lipid metabolism (By similarity). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation. This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of CFL1/cofilin, leading to cofilin activation. Positively regulates axon extension and axon growth cone size in spinal motor neurons. Required for SMCR8 protein expression and localization at pre- and post-synaptic compartments in the forebrain, also regulates protein abundance of RAB3A and GRIA1/GLUR1 in post-synaptic compartments in the forebrain and hippocampus (By similarity). Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity.
messages: Component of the C9orf72-SMCR8 complex, at least composed of C9orf72, SMCR8 and WDR41 (By similarity). The complex is formed of two protomers, each individually consisting of one molecule each of C9orf72, SMCR8 and WDR41 (By similarity). The protomers homodimerize via an interaction between C9orf72 (via C-terminus) and SMCR8 (via N-terminus) (By similarity). Within each protomer SMCR8 (via DENN domain) acts as a bridging protein between WDR41 (via C-terminus and N-terminus) and C9orf72 (via C-terminus) (By similarity). The C9orf72-SMCR8 complex associates with the ULK1/ATG1 kinase complex. Interacts with ULK1/ATG1 kinase complex members ULK1, ATG13 and RB1CC1. Interacts with SMCR8; the interaction is direct (By similarity). Interacts with HNRNPA1, HNRNPA2B1 and UBQLN2. Interacts with small Rab GTPase RAB1A; the interaction mediates recruitment of RAB1A to the ULK1/ATG1 kinase complex. Also interacts with small Rab GTPase RAB7A. Interacts with cofilin (By similarity). Interacts with GTP-binding proteins ARF1 and ARF6. Interacts with the DLG4/PSD-95 (By similarity). Interacts with CARM1 (via PH domain-like fold) (By similarity).
messages: Cytoplasm
messages: Endosome
messages: Lysosome
messages: Nucleus
messages: P-body
messages: Perikaryon
messages: Secreted
messages: Stress granule
messages: autophagosome
messages: axon
messages: growth cone

10116:Zbtb44
gene id: 10116:Zbtb44
uniprot id: Q3SWU4
names: Subcellular Location Annotation
messages: Nucleus

10116:Clca4l
gene id: 10116:Clca4l
uniprot id: Q05KA7
names: Similarity
messages: Belongs to the CLCR family.

10116:Slc35g3
gene id: 10116:Slc35g3
uniprot id: B0K004
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35G solute transporter family.
messages: Membrane

10116:Scn2b
gene id: 10116:Scn2b
uniprot id: P54900
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family.
messages: Brain specific.
messages: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.
messages: Detected in the earliest phase of neurogenesis in brain, and expression is greatly increased concomitant with axon extension and synaptogenesis.
messages: Membrane
messages: The voltage-sensitive sodium channel consists of an ion-conducting pore-forming alpha subunit (such as SCN2A or SCN8A) regulated by one or more beta subunits (SCN1B, SCN2B, SCN3B and SCN4B). SCN1B and SCN3B are non-covalently associated with the alpha subunit. SCN2B and SCN4B are disulfide-linked to the alpha subunit (PubMed:26894959). Interacts with SCN10A and TNR.

10116:Srf
gene id: 10116:Srf
uniprot id: A6JIQ4
uniprot id: D3ZHH8
names: Subcellular Location Annotation
messages: Nucleus

10116:Sag
gene id: 10116:Sag
uniprot id: P15887
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the arrestin family.
messages: Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells.
messages: Membrane
messages: Monomer. Homodimer. Homotetramer. Interacts with RHO (via the phosphorylated C-terminus).
messages: Retina and pineal gland.
messages: The C-terminus interferes with binding to non-phosphorylated RHO. Interaction with phosphorylated RHO triggers displacement of the C-terminus and leads to a conformation change that mediates high-affinity RHO binding.
messages: photoreceptor outer segment

10116:Or4f14f
gene id: 10116:Or4f14f
uniprot id: A6HP35
uniprot id: D3ZWD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Vil1
gene id: 10116:Vil1
uniprot id: A6JVU7
uniprot id: F7F8Y1
names: Similarity
messages: Belongs to the villin/gelsolin family.

10116:Mvd
gene id: 10116:Mvd
uniprot id: Q62967
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Was originally thought to be located in the peroxisome (By similarity). However, was later shown to be cytosolic (PubMed:11725955).

10116:Dars1
gene id: 10116:Dars1
uniprot id: A9CMB7
uniprot id: A9CMD0
uniprot id: P15178
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
messages: Cytoplasm
messages: Homodimer (PubMed:2642907). Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (By similarity).

10116:Timm17a
gene id: 10116:Timm17a
uniprot id: A6ICE7
uniprot id: O35092
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Component of the TIM23 complex at least composed of TIMM23, some TIM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex. The complex also interacts with DNAJC15 (By similarity).
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

10116:Pon1
gene id: 10116:Pon1
uniprot id: P55159
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.
messages: Homodimer. Interacts with CLU.
messages: Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification.
messages: Plasma. Associated with HDL.
messages: The preferential association of PON1 with HDL is mediated in part by its signal peptide, by binding phospholipids directly, rather than binding apo AI. The retained signal peptide may allow transfer of the protein between phospholipid surfaces.
messages: The signal sequence is not cleaved.
messages: extracellular space

10116:Taf1a
gene id: 10116:Taf1a
uniprot id: Q3B7U2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with UBFT (By similarity). Interacts with CEBPA (isoform 1 and isoform 4) (PubMed:20075868).
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits (By similarity).
messages: Nucleus

10116:Klc3
gene id: 10116:Klc3
uniprot id: A6J8N0
uniprot id: Q68G30
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the kinesin light chain family.
messages: Expressed in postmeiotic male germ cells (at protein level).
messages: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (By similarity). May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece (By similarity).
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Mitochondrion
messages: Oligomer composed of two heavy chains and two light chains. Associates with microtubulin in an ATP-dependent manner (PubMed:11319135). Interacts with KIF5C (PubMed:11319135). Interacts with ODF1 (PubMed:12594206). Interacts with LRGUK (By similarity). Interacts with VDAC2 (By similarity).
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding.
messages: cytoskeleton

10116:Lect2
gene id: 10116:Lect2
uniprot id: A6KAM7
uniprot id: D4A526
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

10116:Ntn4
gene id: 10116:Ntn4
uniprot id: A6IFZ2
uniprot id: F1M4Q9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Lcn5
gene id: 10116:Lcn5
uniprot id: A6JT98
uniprot id: P06911
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Associates with spermatozoa in the epididymal fluid but does not bind tightly to them. Binds both all-trans and 9-cis retinoic acid. May act as a retinoid carrier protein which is required for epididymal function and/or sperm maturation.
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted
messages: Synthesized exclusively in the proximal part (caput epididymidis) of the epididymis. It makes up a substantial part of the total protein in the epididymal luminal fluid and binds to the sperm membrane.
messages: The N-terminus of form C is probably blocked.
messages: There are two similar, immunologically cross-reacting forms of this protein, designated B and C, which probably result from different processing of the amino end.

10116:Tpm2
gene id: 10116:Tpm2
uniprot id: A6IJ28
uniprot id: P58775
uniprot id: Q5FVG5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tropomyosin family.
messages: Binds to actin filaments in muscle and non-muscle cells (PubMed:7568216, PubMed:22812662). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:22812662). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity).
messages: Homodimer (PubMed:7568216, PubMed:22812662). Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain (PubMed:7568216, PubMed:22812662).
messages: Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization (By similarity).
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: cytoskeleton

10116:Vmp1
gene id: 10116:Vmp1
uniprot id: Q91ZQ0
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the VMP1 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Highly expressed in intestine, kidney, ovary and placenta, moderately expressed in liver, lung, stomach, thymus, brain, and testis and slightly expressed in control thyroid and retina. Strongly expressed in pancreas (acinar cells) during acute pancreatitis.
messages: Interacts with BECN1 (PubMed:17940279). Interacts with TJP1. Interacts with TP53INP2. Interacts with TMEM41B. Interacts with ATP2A2, PLN and SLN; competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2. Interacts with ATG2A (By similarity).
messages: Overexpressed only in pancreas during acute pancreatitis. Up-regulated by starvation. Up-regulated following MTOR-inhibition by rapamycin.
messages: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (By similarity). Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine (By similarity). Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly (By similarity). Regulates ATP2A2 activity to control ER-isolation membrane contacts for autophagosome formation (PubMed:17940279). In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (By similarity). Modulates ER contacts with lipid droplets, mitochondria and endosomes (By similarity). Plays an essential role in formation of cell junctions (By similarity). Upon stress such as bacterial and viral infection, promotes formation of cytoplasmic vacuoles followed by cell death (PubMed:11785947, PubMed:12649568, PubMed:15367889). Involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (PubMed:11785947, PubMed:12649568, PubMed:15367889).
messages: The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
messages: Vacuole membrane

10116:Rgs8
gene id: 10116:Rgs8
uniprot id: P49804
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Detected in 13-day old embryos. Expression increases gradually in later embryos and markedly in neonates to adults.
messages: Expressed at high levels in brain. Very little expression detected in other tissues (PubMed:9394004). Detected in Purkinje cells in the cerebellum (PubMed:12880183).
messages: Interacts with GNAO1 and GNAI3.
messages: Membrane
messages: Nucleus
messages: Perikaryon
messages: Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling.
messages: dendrite

10116:Tsg101
gene id: 10116:Tsg101
uniprot id: A6JBD7
uniprot id: Q6IRE4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with VPS37A, VPS37B and VPS37C. Interacts with DMAP1. Interacts with ubiquitin (By similarity). Interacts with AATF (PubMed:14761944). Interacts with stathmin and GMCL (By similarity). Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with HGS; the interaction mediates the association with the ESCRT-0 complex. Interacts with GGA1 and GGA3. Interacts (via UEV domain) with PDCD6IP/AIP1. Interacts with VPS28, SNF8 and VPS36. Self-associates. Interacts with MVB12A; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37D. Interacts with LRSAM1. Interacts with CEP55; the interaction is required for cytokinesis. Interacts with PDCD6. Interacts with LITAF. Interacts with MGRN1 (By similarity). Interacts with ARRDC1; recruits TSG101 to the plasma membrane (By similarity).
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (By similarity).
messages: Cytoplasm
messages: Early endosome membrane
messages: Late endosome membrane
messages: Midbody ring
messages: Monoubiquitinated at multiple sites by LRSAM1 and by MGRN1. Ubiquitination inactivates it, possibly by regulating its shuttling between an active membrane-bound protein and an inactive soluble form. Ubiquitination by MGRN1 requires the presence of UBE2D1.
messages: Nucleus
messages: The UEV domain is required for the interaction of the complex with ubiquitin.
messages: The coiled coil domain may interact with stathmin.
messages: centrosome

10116:Ddx23
gene id: 10116:Ddx23
uniprot id: B5DFJ3
names: Similarity
messages: Belongs to the DEAD box helicase family.

10116:Ppia
gene id: 10116:Ppia
uniprot id: A0A8L2R8V9
uniprot id: A6IKU0
uniprot id: P10111
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization (By similarity). PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition (By similarity). Acetylation at Lys-125 favors the interaction with TARDBP (By similarity).
messages: Belongs to the cyclophilin-type PPIase family.
messages: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
messages: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).
messages: Cytoplasm
messages: Interacts with protein phosphatase PPP3CA/calcineurin A (By similarity). Interacts with isoform 2 of BSG/CD147 (By similarity). Interacts with FOXO1; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (By similarity). Interacts with integrin ITGA2B:ITGB3; the interaction is ROS and peptidyl-prolyl cis-trans isomerase (PPIase) activity-dependent and is increased in the presence of thrombin (By similarity). Interacts with MAP3K5 (By similarity). Interacts with TARDBP; the interaction is dependent on the RNA-binding activity of TARDBP and the PPIase activity of PPIA/CYPA and the acetylation of PPIA/CYPA at Lys-125 favors the interaction (By similarity). Interacts with HNRNPA1, HNRNPA2B1, HNRNPC, RBMX, HNRNPK and HNRNPM (By similarity).
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
messages: Secreted

10116:Dpysl5
gene id: 10116:Dpysl5
uniprot id: A6HAC3
uniprot id: Q9JHU0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Cytoplasm
messages: Highly expressed in embryonic and early postnatal brain and spinal cord.
messages: Homotetramer, and heterotetramer with other DPYS-like proteins. Interacts with DPYSL2, DPYSL3 and DPYSL4 (By similarity). Interacts with MAP2 and TUBB3 (By similarity).
messages: Involved in the negative regulation of dendrite outgrowth.
messages: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.

10116:Ddx47
gene id: 10116:Ddx47
uniprot id: A6IMF0
uniprot id: Q5BIZ6
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

10116:Bora
gene id: 10116:Bora
uniprot id: Q5M864
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the BORA family.
messages: Interacts with AURKA.
messages: Phosphorylated by AURKA.
messages: Required for the activation of AURKA at the onset of mitosis.

10116:Soga3
gene id: 10116:Soga3
uniprot id: A0A8I6A680
names: Similarity
messages: Belongs to the SOGA family.

10116:Ss18l1
gene id: 10116:Ss18l1
uniprot id: Q91XJ0
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SS18 family.
messages: Brain (at protein level). Also found in the heart, liver, kidney and testis.
messages: Detected as early as 18 dpc in the developing cerebral cortex, and expression reaches its peak at P1, declines after P10, and remains at a relatively low level throughout adulthood. At 18 dpc, expressed in the forebrain, midbrain, and hindbrain. Within the forebrain, it is expressed in postmitotic cells of the cortical plate. At this stage, it can also be detected in other structures of central and peripheral nervous systems, including the trigeminal ganglion, superior cervical ganglion, retina and olfactory epithelium. Expression in the cortex is high at birth and declines substantially by P20. At P7, expressed in all cortical layers, and in the hippocampus, expression is high in the cell body layers of all subdivisions. Within the brain, expression decreases through development but continues to be expressed at high levels in the olfactory bulb, hippocampus, and cerebellum into adulthood.
messages: Homodimer. Dimerization may be necessary for its function in neuronal dendritic development. Interacts (via C-terminus) with CREBBP (via N-terminus), EP300 and SMARCA4/BRG1. Interacts with the nBAF complex (By similarity). Association with CREBBP facilitates transcription while the association with SMARCA4/BRG1 suppresses CREST-mediated transcription in resting neurons.
messages: Nucleus
messages: The MFD (multi-functional domain) domain is involved in transcription transactivation, nuclear body targeting and dimerization. Inhibits dendritic growth in cultured neurons.
messages: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP.
messages: kinetochore

10116:Dhodh
gene id: 10116:Dhodh
uniprot id: Q63707
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane
messages: Monomer.
messages: The uncleaved transit peptide is required for mitochondrial targeting and proper membrane integration.

10116:Asic4
gene id: 10116:Asic4
uniprot id: A6JW35
uniprot id: G3V8N2
uniprot id: Q9JHS6
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC4 subfamily.
messages: Expressed in brain, spinal cord and dorsal root ganglion (DRG). Expressed by a subset of sensory neurons in the DRG. Expressed by granule cells in the cerebellar cortex. In hippocampus, expression is detected in dentate gyrus granule cells, in pyramidal cells of CA1-CA3 subfields and in interneurons of the striatum oriens and radiatum of all subfields. In cerebral cortex expressed in small, medium and large pyramidal cells in layers 2, 3 and 5 respectively. Also expressed in striatum, globus pallidus, inferior and superior calliculi, amygdala, magnocellular preoptic nucleus, islands of Calleja and large neurons of olfactory tubercules.
messages: Highly expressed in newborn spinal cord but hardly detected in the cerebellum compared to adult. Expressed at postnatal day 1 in ependymal cells lining the central canal of spinal cord and in motor neurons. In adult, expression decreases in ependymal cells and increases in motor neurons. The number of positive interneurons decreases but the individual interneuron expression increases in adult spinal cord compared to newborn.
messages: Homotrimer or heterotrimer with other ASIC proteins.
messages: In vitro, has no proton-gated channel activity.
messages: Membrane
messages: Probable cation channel with high affinity for sodium.

10116:Fads2
gene id: 10116:Fads2
uniprot id: A6I009
uniprot id: Q9Z122
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane
messages: Expressed in the liver and brain (at protein level) (PubMed:11988075). Highest activity is found in the liver and adrenals followed by the testes and other organs, absent in adipose tissue (PubMed:5094766).
messages: Inhibited by a shortage of insulin and an increase of glucagon.
messages: Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (PubMed:10049752, PubMed:22216341, PubMed:11988075, PubMed:14563830, PubMed:24070791). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (PubMed:11988075). It can also desaturate (11E)-octadecenoate (trans-vaccenoate) at carbon 6 generating (6Z,11E)-octadecadienoate (PubMed:24070791). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity).
messages: Microsome membrane
messages: The protein sequence includes a number of characteristic features of microsomal fatty acid desaturases including the three histidine boxes HXXXH, HXXHH, and QXXHH (these domains may contain the active site and/or be involved in metal ion binding), and the N-terminal cytochrome b5 domain containing the heme-binding motif, HPGG, similar to that of other fatty acid desaturases.

10116:Grb2
gene id: 10116:Grb2
uniprot id: A6HKQ4
uniprot id: P62994
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
messages: Associates (via SH2 domain) with activated EGF and PDGF receptors (tyrosine phosphorylated). Interacts with PDGFRA (tyrosine phosphorylated); the interaction may be indirect. Interacts with IRS4 (when Tyr-phosphorylated). Also associates to other cellular Tyr-phosphorylated proteins such as SIT1, SHC and LNK; probably via the concerted action of both its SH2 and SH3 domains. It also seems to interact with RAS in the signaling pathway leading to DNA synthesis. Interacts with SOS1. Forms a complex with MUC1 and SOS1, through interaction of the SH3 domains with SOS1 and the SH2 domain with phosphorylated MUC1. Interacts with phosphorylated MET. Interacts with phosphorylated TOM1L1. Interacts with the phosphorylated C-terminus of SH2B2. Interacts with phosphorylated SIT1, LAX1, LAT, LAT2 and LIME1 upon TCR and/or BCR activation. Interacts with NISCH, PTPNS1 and REPS2. Interacts with syntrophin SNTA1. Interacts (via SH3 domains) with REPS1. Interacts (via SH3 domains) with PIK3C2B. Interacts with CBL and CBLB. Interacts with AJUBA and CLNK. Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated). Interacts with SHB, INPP5D/SHIP1, SKAP1 and SKAP2. Interacts with PTPN11. Interacts with PRNP. Interacts with RALGPS1. Interacts also with HCST. Interacts with KDR. Interacts with FLT1 (tyrosine-phosphorylated). Interacts with GAPT and PTPRE. Interacts (via SH2 domain) with KIF26A. Interacts (via SH3 2) with GAB2. Interacts with ADAM15. Interacts with THEMIS2. Interacts (via SH2 domain) with AXL (phosphorylated). Interacts (via SH2 domain) with KIT (phosphorylated). Interacts with PTPRJ and BCR. Interacts with PTPN23. Interacts with FLT4 (tyrosine phosphorylated). Interacts with EPHB1 and SHC1; activates the MAPK/ERK cascade to regulate cell migration. Part of a complex including TNK2, GRB2 and one receptor tyrosine kinase (RTK) such as AXL and PDGFRL, in which GRB2 promotes RTK recruitment by TNK2. Interacts with ERBB4. Interacts with NTRK1 (phosphorylated upon ligan…
messages: Belongs to the GRB2/sem-5/DRK family.
messages: Cytoplasm
messages: Endosome
messages: Golgi apparatus
messages: Nucleus
messages: The SH3 domains mediate interaction with RALGPS1 and SHB.
messages: Wide tissue distribution.

10116:Ift80
gene id: 10116:Ift80
uniprot id: Q66HB3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (By similarity). Interacts with IFT88 (By similarity). Interacts with IFT57 and IFT70B (By similarity).
messages: Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia.
messages: Cytoplasm
messages: cilium axoneme
messages: cilium basal body

10116:Hadha
gene id: 10116:Hadha
uniprot id: A6HAE4
uniprot id: Q64428
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Heterotetramer of 2 alpha/HADHA and 2 beta/HADHB subunits; forms the mitochondrial trifunctional enzyme (By similarity). Also purified as higher order heterooligomers including a 4 alpha/HADHA and 4 beta/HADHB heterooligomer which physiological significance remains unclear (PubMed:1730633). The mitochondrial trifunctional enzyme interacts with MTLN (By similarity).
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity. Independently of the subunit beta, the trifunctional enzyme subunit alpha/HADHA also has a monolysocardiolipin acyltransferase activity. It acylates monolysocardiolipin into cardiolipin, a major mitochondrial membrane phospholipid which plays a key role in apoptosis and supports mitochondrial respiratory chain complexes in the generation of ATP. Allows the acylation of monolysocardiolipin with different acyl-CoA substrates including oleoyl-CoA for which it displays the highest activity.
messages: Mitochondrion
messages: Mitochondrion inner membrane

10116:Dlgap2
gene id: 10116:Dlgap2
uniprot id: P97837
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SAPAP family.
messages: Cell membrane
messages: Expressed in various brain areas.
messages: Interacts with DLG4/PSD-95.
messages: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
messages: Postsynaptic density
messages: Synapse

10116:Junb
gene id: 10116:Junb
uniprot id: A6IY42
uniprot id: P24898
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. Jun subfamily.
messages: Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Component of an AP-1 transcription factor complex (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with FOSB, thereby binding to the AP-1 consensus sequence and stimulating transcription (By similarity). Interacts with NFE2 (via its WW domains).
messages: By growth factors.
messages: Nucleus
messages: Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity).
messages: Ubiquitinated by ITCH, leading to its degradation.

10116:Fgd3
gene id: 10116:Fgd3
uniprot id: A0A0G2K2U9
uniprot id: A6J6W8
uniprot id: A6J6W9
uniprot id: D3ZS34
names: Subcellular Location Annotation
messages: cytoskeleton

10116:Snrpd1
gene id: 10116:Snrpd1
uniprot id: A6KNE7
uniprot id: F7F176
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts (via C-terminus) with SMN1 (via Tudor domain); the interaction is direct. Interacts with GEMIN2; the interaction is direct. Interacts with SNRPD2; the interaction is direct.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
messages: cytosol

10116:Cda
gene id: 10116:Cda
uniprot id: A6ITH4
uniprot id: D4AC20
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

10116:Ndor1
gene id: 10116:Ndor1
uniprot id: A6JT23
uniprot id: D4ABT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.
messages: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair.
messages: perinuclear region

10116:Nrn1
gene id: 10116:Nrn1
uniprot id: O08957
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the neuritin family.
messages: Cell membrane
messages: Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing.
messages: Expressed predominantly in brain (at protein level). Highest expression in the dentate gyrus and lowest expression in the striatum. Concentrated on neuronal cell bodies and unevenly dispersed along neuritic projections in the nonmyelinated regions of the brain. Expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult.
messages: Expression first detected in developing brain at embryonic day 15; the level of expression increases throughout embryonic development and postnatally into adulthood.
messages: Induced by neural activity and by the activity-regulated neurotrophins BDNF and NTF3.
messages: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.
messages: Synapse

10116:Nxph4
gene id: 10116:Nxph4
uniprot id: A0A0G2JSW7
uniprot id: Q9Z2N4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the neurexophilin family.
messages: Brain and kidney.
messages: May be proteolytically processed in neuron-like cells.
messages: May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

10116:Ccdc126
gene id: 10116:Ccdc126
uniprot id: B5DEZ3
uniprot id: F7ERE0
names: Subcellular Location Annotation
messages: Secreted

10116:Gpbp1
gene id: 10116:Gpbp1
uniprot id: A0A0G2K5K6
uniprot id: A6I5M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

10116:Rbpj
gene id: 10116:Rbpj
uniprot id: A6IJF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

10116:Itpr2
gene id: 10116:Itpr2
uniprot id: P29995
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer (PubMed:12032348). Interacts with CABP1 (PubMed:12032348). Interacts with BOK; regulates ITPR2 expression (PubMed:23884412). Interacts with BCL2L10 (By similarity). Interacts with TRPC4 (PubMed:11163362).
messages: Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity).
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

10116:Serpinb13
gene id: 10116:Serpinb13
uniprot id: A6JSV5
uniprot id: D3ZKA0
names: Similarity
messages: Belongs to the serpin family.

10116:Ahrr
gene id: 10116:Ahrr
uniprot id: Q75NT5
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Highly expressed in testis and weakly expressed in heart and liver. Highly expressed in small intestine and cecum in a male-dominant sexual dimorphic fashion.
messages: Increased after TCDD exposure in liver. Highly increased after TCDD exposure in kidney, spleen and heart. Up-regulated by 3-MC in small intestine.
messages: Interacts with ARNT, ANKRA2, HDAC4 and HDAC5. Interacts with ARNT; forms a heterodimer with ARNT (By similarity).
messages: Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
messages: Nucleus

10116:Rhox4g
gene id: 10116:Rhox4g
uniprot id: Q4TU78
names: Subcellular Location Annotation
messages: Nucleus

10116:Mest
gene id: 10116:Mest
uniprot id: Q6P5P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily.
messages: Endoplasmic reticulum membrane

10116:Astl
gene id: 10116:Astl
uniprot id: A6HQ13
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Ttc19
gene id: 10116:Ttc19
uniprot id: D4A6D7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TTC19 family.
messages: Binds to the mature mitochondrial complex III dimer, after the incorporation of the Rieske protein UQCRFS1. Interacts with UQCRC1 and UQCRFS1 (By similarity). Interacts with ZFYVE26 and CHMP4B.
messages: Mitochondrion inner membrane
messages: Proteolytically cleaved by PARL.
messages: Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1. Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation into the complex III and whose presence is detrimental for its catalytic activity.

10116:Car7
gene id: 10116:Car7
uniprot id: A6JXV1
uniprot id: F7FEQ2
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

10116:Gadd45a
gene id: 10116:Gadd45a
uniprot id: B2DBD9
uniprot id: Q66HL6
names: Similarity
messages: Belongs to the GADD45 family.

10116:Xlr4a
gene id: 10116:Xlr4a
uniprot id: A6KSZ1
names: Similarity
messages: Belongs to the XLR/SYCP3 family.

10116:Pipox
gene id: 10116:Pipox
uniprot id: Q5I0K1
names: Similarity
messages: Belongs to the MSOX/MTOX family.

10116:Fads3
gene id: 10116:Fads3
uniprot id: Q8K1P9
uniprot id: R4HD46
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane
messages: Essentially expressed in liver and kidney and to a lesser extent in heart, adipose tissue, stomach and pancreas (at protein level) (PubMed:19752397). Higher expression in lactating mammary gland than in liver (PubMed:30262139).
messages: Mammals have different sphingoid bases that differ in their length and/or pattern of desaturation and hydroxyl groups. The predominant sphingoid base that comprises mammalian ceramides is sphing-4-enine (sphingosine or SPH) which has a trans (E) desaturation at carbon 4. FADS3 is a desaturase that introduces a cis (Z) double bond between carbon 14 and carbon 15 of the sphingoid base (also known as long chain base, LCB), producing LCBs such as sphinga-4,14-dienine (SPD, d18:2(4E,14Z)) from SPH. Prefers SPH-containing ceramides (N-acylsphing-4-enines) as substrates. Capable of metabolizing also the SPH in its free form. SPD ceramides occur widely in mammalian tissues and cells. Due to their unusual structure containing a cis double bond, SPD ceramides may have an opposite, negative role in lipid microdomain formation relative to conventional ceramides. Could be involved in the detoxification of 1-deoxy sphingolipids, by desaturating the cytotoxic 1-deoxysphinganine (1-deoxySA, m18:0), produced under pathological conditions, to 1-deoxysphingenine (1-deoxysphingosine, 1-deoxySO, m18:1). Although prefers SPH-containing ceramides (N-acylsphing-4-enines) as substrates, it also exhibits activity toward dihydrosphingosine-containing CERs (N-acylsphinganines) and produces 14Z-SPH-containing sphingolipids. Its desaturase mechanism involves an electron transfer facilitated by cytochrome b5 (By similarity). FADS3 also acts as a methyl-end fatty acyl coenzyme A (CoA) desaturase that introduces a cis double bond between the preexisting double bond and the terminal methyl group of the fatty acyl chain. Desaturates (11E)-octadecenoate (trans-vaccenoate, the predominant trans fatty acid in human milk) at carbon 13 to generate (11E,13Z)-octadecadienoate (also known as conjugated linoleic acid 11E,13Z-CLA) (PubMed:24070791, PubMed:30262139).
messages: The protein sequence includes a number of characteristic features of microsomal fatty acid desaturases including the three histidine boxes (these domains may contain the active site and/or be involved in metal ion binding), and the N-terminal cytochrome b5 domain containing the heme-binding motif, HPGG, similar to that of other fatty acid desaturases.
messages: Two potential isoforms are detected in various tissues. A 75 kDa isoform is expressed in lung, spleen and thymus. A 37 kDa isoform is highly expressed in skeletal and abdominal muscles, brain and ovary and to a lesser extent in heart, lung, brown adipose tissue and eye.

10116:Smpd3
gene id: 10116:Smpd3
uniprot id: O35049
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the neutral sphingomyelinase family.
messages: Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location (By similarity). Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. May be involved in IL-1-beta-induced JNK activation in hepatocytes. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: In brain sections, it is restricted to neurons and especially prominent in large cells, including Purkinje cells, pyramidal cells, neurons of the dentate gyrus granular layer, and neurons in the pontine nuclei. Also present in the hypothalamic nuclei, neurons in the piriform cortex, and nuclei of the brainstem (at protein level). Mainly expressed in brain and jejunum. Weakly or not expressed in heart, spleen, lung, liver, kidney and testis.
messages: Inhibited by nSMase inhibitor GW4869. Binding of anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) increases enzymatic activity.
messages: Palmitoylated, palmitoylation-deficient proteins are targeted for lysosomal degradation.

10116:Cytip
gene id: 10116:Cytip
uniprot id: Q5I0L6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.
messages: Cytoplasm
messages: Early endosome
messages: Interacts with CYTH1 and SNX27.

10116:Itm2b
gene id: 10116:Itm2b
uniprot id: A6HTQ5
uniprot id: Q5XIE8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ITM2 family.
messages: Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.
messages: Cell membrane
messages: Endosome membrane
messages: Glycosylation at Asn-170 is important for cell surface localization, but doesn't affect furin- and ADAM10-induced proteolytic processing.
messages: Golgi apparatus membrane
messages: Homodimer; disulfide-linked. Interacts with SPPL2A and SPPL2B. Interacts with APP. Mature BRI2 (mBRI2) interacts with the APP amyloid-beta A4 protein; the interaction occurs at the cell surface and in the endocytic compartments and enable alpha- and beta-secretase-induced APP cleavage inhibition. Mature BRI2 (mBRI2) interacts with the APP C99; the interaction occurs in the endocytic compartments and enable gamma-secretase-induced C99 cleavage inhibition. May form heterodimers with Bri23 peptide and APP amyloid-beta protein 40 (By similarity). Interacts with ADAM7 in sperm; the interaction increases following capacitation (By similarity).
messages: Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.
messages: Membrane
messages: Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity).
messages: Secreted
messages: The ectodomain C-terminal part of the imBRI2 is processed by furin producing a secreted Bri23 peptide and a mature BRI2, membrane form (mBRI2). The remaining part of the ectodomain of mBRI2 containing the BRICHOS domain is cleaved by ADAM10 and is secreted (BRI2C, soluble form). The membrane-bound N-terminal fragment (BRI2C, membrane form) is further proteolytically processed by SPPL2A and SPPL2B through regulated intramembrane proteolysis producing a secreted C-peptide and a BRI2 intracellular domain (BRI2 ICD) released in the cytosol. Shedding by ADAM10 facilitates intramembrane cleavage but is not absolutely required for BRI2 ICD generation (By similarity).

10116:Tnp2
gene id: 10116:Tnp2
uniprot id: A6K4I8
uniprot id: F7F3S7
uniprot id: P11101
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear transition protein 2 family.
messages: Chromosome
messages: Expressed during stages 12-15 of spermiogenesis.
messages: Nucleus
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals (PubMed:11772016). In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (By similarity).
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
messages: Testis.
messages: nucleolus

10116:Npc1
gene id: 10116:Npc1
uniprot id: A6KNH0
uniprot id: G3V7K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

10116:Nlrp10
gene id: 10116:Nlrp10
uniprot id: A6I7U9
uniprot id: D3ZUA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NLRP family.
messages: Inflammasome

10116:Saraf
gene id: 10116:Saraf
uniprot id: A6IVP3
uniprot id: Q6AYN2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.
messages: Membrane
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions (By similarity).
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.
messages: The cytoplasmic C-terminal region mediates interaction with STIM1, while the N-terminal lumenal region mediates regulation of SOCE activity.

10116:Gins1
gene id: 10116:Gins1
uniprot id: A6KHH3
uniprot id: F7EXT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

10116:Irf3
gene id: 10116:Irf3
uniprot id: F7EXX5
uniprot id: Q5XIB0
names: Subcellular Location Annotation
messages: Nucleus

10116:Actrt2
gene id: 10116:Actrt2
uniprot id: Q5XIK3
names: Similarity
messages: Belongs to the actin family.

10116:Sycp2
gene id: 10116:Sycp2
uniprot id: O70608
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SYCP2 family.
messages: Chromosome
messages: Component of the lateral elements of synaptonemal complexes (PubMed:9592139, PubMed:9933407). Interacts with TEX11 (By similarity). Heterodimer with SYCP3. Interacts with SYCP3, SMC1A and SMC3 (PubMed:10652260).
messages: Detected in spermatocytes and testis (at protein level) (PubMed:9592139, PubMed:9933407). Spermatocytes and oocytes. Meiotic prophase cells.
messages: Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase (PubMed:9592139, PubMed:9933407). Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements.
messages: Meiosis-specific. Highly expressed in meiotic prophase cells, low expression persists in spermatids.
messages: Nucleus
messages: Phosphorylated.

10116:Pex10
gene id: 10116:Pex10
uniprot id: A6IUN3
uniprot id: D3ZC81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Membrane
messages: Peroxisome membrane

10116:Ndufb3
gene id: 10116:Ndufb3
uniprot id: A6IP76
uniprot id: D4A4P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

10116:Vps52
gene id: 10116:Vps52
uniprot id: B2GUV2
uniprot id: O55166
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.
messages: Belongs to the VPS52 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54. Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin (By similarity). The EARP complex interacts with EIPR1 (PubMed:27440922). EIPR1 interacts with GARP complex and mediates its recruitment to the trans-Golgi network. Interacts with RAB6A and STX10. Interacts with BLTP3B (By similarity).
messages: Endosome membrane
messages: Recycling endosome
messages: Ubiquitous.
messages: trans-Golgi network membrane

10116:Imp3
gene id: 10116:Imp3
uniprot id: B2RZ12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS4 family.
messages: nucleolus

10116:P2rx2
gene id: 10116:P2rx2
uniprot id: A0A0G2K9G8
uniprot id: A6J2A8
uniprot id: A6J2B0
uniprot id: A6J2B1
uniprot id: P49653
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the P2X receptor family.
messages: Cell membrane
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: High levels in pituitary and vas deferens. Lower extent in spinal cord, bladder, brain, adrenal, testis, sensory epithelia from the inner ear.
messages: Homotrimer and heterotrimer; functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

10116:Pde11a
gene id: 10116:Pde11a
uniprot id: Q8VID6
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: Inhibited by 3-isobutyl-1-methylxanthine (IBMX), zaprinast and dipyridamole. cGMP acts as an allosteric activator.
messages: Isoform 1 is expressed in brain, heart, kidney and liver, but not in prostate. Isoform 2 is specifically expressed in testis. Isoform 3 is expressed in various tissues including brain, lung, skeletal muscle, spleen, testis and prostate.
messages: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:11502204). Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:11502204).
messages: The tandem GAF domains bind cGMP, and regulate enzyme activity. The binding of cGMP stimulates enzyme activity.
messages: cytosol

10116:Reep3
gene id: 10116:Reep3
uniprot id: B0BNL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

10116:Spc25
gene id: 10116:Spc25
uniprot id: A6HLZ8
uniprot id: Q5M856
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end (By similarity).
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

10116:Cldn16
gene id: 10116:Cldn16
uniprot id: A0A0G2K8J2
uniprot id: A6JRY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

10116:Cyp26b1
gene id: 10116:Cyp26b1
uniprot id: G3V7X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (By similarity). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (By similarity). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (By similarity). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (By similarity). Involved in the convertion of atRA to all-trans-4-oxo-RA. Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). Shows preference for the following substrates: atRA > 9-cis-RA > 13-cis-RA (By similarity). Plays a central role in germ cell development: acts by degrading RAs in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. Essential for postnatal survival (By similarity).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.
messages: Microsome membrane

10116:Hspa1a
gene id: 10116:Hspa1a
uniprot id: A6KTP2
uniprot id: P0DMW0
uniprot id: P0DMW1
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the heat shock protein 70 family.
messages: By heat shock.
messages: Component of the CatSper complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2. Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts with METTL21A. Interacts with DNAAF2. Interacts with TRIM5 (via B30.2/SPRY domain). Interacts with PRKN. Interacts with FOXP3. Interacts with NOD2; the interaction enhances NOD2 stability. Interacts with DNAJC9 (via J domain). Interacts with ATF5; the interaction protects ATF5 from degradation via proteasome-dependent and caspase-dependent processes. Interacts with RNF207 (via the C-terminus); this interaction additively increases KCNH2 expression. Interacts with HSF1 (via transactivation domain); this interaction results in the inhibition of heat shock- and HSF1-induced transcriptional activity during the attenuation and recovery phase period of the heat shock response. Interacts with NAA10, HSP40, HSP90 and HDAC4. The acetylated form and the non-acetylated form interact with HOPX and STUB1 respectively. Interacts with NEDD1 and SMAD3. Interacts (via NBD) with BAG1, BAG2, BAG3 and HSPH1/HSP105. Interacts with DNAJC8. Interacts with NLRP12. Interacts with PGLYRP.
messages: Cytoplasm
messages: HSPA1B is testis-specific.
messages: In response to cellular stress, acetylated at Lys-77 by NA110 and then gradually deacetylated by HDAC4 at later stages. Acetylation enhances its chaperone activity and also determines whether it will function as a chaperone for protein refolding or degradation by controlling its binding to co-chaperones HOPX and STUB1. The acetylated form and the non-acetylated form bind to HOPX and STUB1 respectively. Acetylation also protects cells against various types of cellular stress.
messages: May be an auxiliary component of the CatSper complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2. Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts with METTL21A. Interacts with TRIM5 (via B30.2/SPRY domain). Interacts with PRKN. Interacts with FOXP3. Interacts with NOD2; the interaction enhances NOD2 stability. Interacts with DNAJC9 (via J domain). Interacts with ATF5; the interaction protects ATF5 from degradation via proteasome-dependent and caspase-dependent processes. Interacts with NAA10, HSP40, HSP90 and HDAC4. The acetylated form and the non-acetylated form interact with HOPX and STUB1 respectively. Interacts with NEDD1 and SMAD3. Interacts (via NBD) with BAG1, BAG2, BAG3 and HSPH1/HSP105. Interacts with DNAJC8.
messages: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein re…
messages: Nucleus
messages: Secreted
messages: The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
messages: centrosome

10116:Thumpd2
gene id: 10116:Thumpd2
uniprot id: A0A0G2KA02
uniprot id: D4A475
names: Similarity
messages: Belongs to the methyltransferase superfamily.

10116:LOC685762
gene id: 10116:LOC685762
uniprot id: F1LVR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

10116:Olr1537
gene id: 10116:Olr1537
uniprot id: D4A2F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Hnf4a
gene id: 10116:Hnf4a
uniprot id: A0A0G2K0G1
uniprot id: A0A0G2K5P1
uniprot id: A2ICG7
uniprot id: A6JX37
uniprot id: B9VVT2
uniprot id: B9VVT3
uniprot id: P22449
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylation at Lys-458 lowers transcriptional activation by about two-fold.
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Binds fatty acids.
messages: DNA-binding activity of phosphorylated protein is reduced by fasting and by inducers of intracellular cyclic AMP.
messages: Homodimerization is required for HNF4-alpha to bind to its recognition site (PubMed:12193589). Interacts with CLOCK, BMAL1, CRY1, CRY2, PER1 and PER2 (By similarity). Interacts with NR0B2/SHP; the resulting heterodimer is transcriptionnally inactive (By similarity). Interacts with DDX3X; this interaction disrupts the interaction between HNF4 and NR0B2 that forms inactive heterodimers and enhances the formation of active HNF4 homodimers (By similarity).
messages: Liver, kidney and intestine.
messages: Nucleus
messages: Phosphorylation at Ser-313 by AMPK reduces the ability to form homodimers and bind DNA (By similarity). Phosphorylated in the recognition sequence R-R-S-S near the DNA-binding domain; phosphorylation results in decrease in DNA-binding activity. Phosphorylation of HNF4 depends on the diet and is decreased by a carbohydrate-rich diet and is increased by fasting.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: The N-terminus is blocked.
messages: Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (By similarity). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (By similarity).

10116:Sav1
gene id: 10116:Sav1
uniprot id: A4V8B4
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer. Stabilized through interaction with STK3/MST2 or STK4/MST1. Interacts (via SARAH domain) with isoform 1 of NEK2. Interacts with ESR1 only in the presence of STK3/MST2. Interacts with WTIP and AJUBA.
messages: Nucleus
messages: Phosphorylated by STK3/MST2 and STK4/MST1. Phosphorylation is not required for SAV1 stability and may increase the number of protein binding sites on the scaffold molecule (By similarity).
messages: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (By similarity).

10116:Or5p78c
gene id: 10116:Or5p78c
uniprot id: A0A0G2KAI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Pfdn5
gene id: 10116:Pfdn5
uniprot id: B5DFN4
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

10116:Ccdc117
gene id: 10116:Ccdc117
uniprot id: Q5M9G5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Facilitates DNA repair, cell cycle progression, and cell proliferation through its interaction with CIAO2B.
messages: Interacts with CIAO2B; the interaction is direct. Interacts with MMS19; the interaction is indirect.
messages: Nucleus
messages: spindle

10116:Sumo2
gene id: 10116:Sumo2
uniprot id: P61959
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
messages: Interacts with SAE2 and UBE2I. Interacts with ZNF451. Identified in a complex with ZNF451 and UBE2I/UBC9, where one ZNF451 interacts with one UBE2I/UBC9 and two SUMO2 chains, one bound to the UBE2I/UBC9 active site and the other to another region of the same UBE2I/UBC9 molecule. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 and SOBP (via SIM domains). Interacts with MTA1 (By similarity). Interacts with HINT1 (By similarity). Interacts with GCNA (via SIM domains); this interaction allows the GCNA recruitment to DPCs sites (By similarity).
messages: Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer.
messages: Nucleus
messages: PML body
messages: Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4 (By similarity).
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity).

10116:Spaca9
gene id: 10116:Spaca9
uniprot id: Q4V8P4
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Interacts with CABP1 and CALR. Interacts with INCA1 (PubMed:18756329). Interacts with microtubules.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) of multiciliated respiratory cells and the distal singlet microtubules of monoflagellated spermatozoa. May stabilize the protofilaments to which they are bound.
messages: Nucleus
messages: Testis-specific. Expressed in round spermatids.
messages: acrosome
messages: cilium axoneme
messages: cilium basal body
messages: flagellum

10116:Or2h2c
gene id: 10116:Or2h2c
uniprot id: Q6MFX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Slc30a10
gene id: 10116:Slc30a10
uniprot id: A6JGR9
uniprot id: D3ZJB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

10116:Or14c43
gene id: 10116:Or14c43
uniprot id: A0A8I6A6E8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Xpnpep1
gene id: 10116:Xpnpep1
uniprot id: A6JHT7
uniprot id: O54975
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M24B family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Expressed in all tissues tested, including liver, adrenal decapsular tissue, adrenal capsular tissue, corpus luteum, testis, submandibular gland, thymus, brain, cerebellum and heart. Highest levels in testis.
messages: Homodimer.
messages: Inhibited by inositol hexakisphosphate.
messages: Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (PubMed:10095056). Contributes to the degradation of bradykinin (By similarity).

10116:Phyhd1
gene id: 10116:Phyhd1
uniprot id: Q5BJP9
names: Function
names: Similarity
messages: 2-oxoglutarate(2OG)-dependent dioxygenase that catalyzes the conversion of 2-oxoglutarate to succinate and CO(2) in an iron-dependent manner. However, does not couple 2OG turnover to the hydroxylation of acyl-coenzyme A derivatives, implying that it is not directly involved in phytanoyl coenzyme-A metabolism. Does not show detectable activity towards fatty acid CoA thioesters.
messages: Belongs to the PhyH family. PHYHD1 subfamily.

10116:Plp1
gene id: 10116:Plp1
uniprot id: A0A097BVK2
uniprot id: A6KNU2
uniprot id: P60203
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Cell membrane
messages: Defects in Plp1 are the cause of the dysmyelinating disease MD.
messages: Membrane
messages: Myelin membrane
messages: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

10116:Pla2g6
gene id: 10116:Pla2g6
uniprot id: P97570
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by ATP (PubMed:18937505, PubMed:9111008). Inhibited by calcium-activated calmodulin (PubMed:11118454, PubMed:18937505). Inhibited by bromoenol lactone (BEL) (PubMed:18937505).
messages: Calcium-independent phospholipase involved in phospholipid remodeling with implications in cellular membrane homeostasis, mitochondrial integrity and signal transduction. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 and A2 activity respectively), producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:18937505, PubMed:9111008). Hydrolyzes both saturated and unsaturated long fatty acyl chains in various glycerophospholipid classes such as phosphatidylcholines, phosphatidylethanolamines and phosphatidates, with a preference for hydrolysis at sn-2 position. Can further hydrolyze lysophospholipids carrying saturated fatty acyl chains (lysophospholipase activity) (PubMed:18937505). Upon oxidative stress, contributes to remodeling of mitochondrial phospholipids in pancreatic beta cells, in a repair mechanism to reduce oxidized lipid content (PubMed:24648512). Preferentially hydrolyzes oxidized polyunsaturated fatty acyl chains from cardiolipins, yielding monolysocardiolipins that can be reacylated with unoxidized fatty acyls to regenerate native cardiolipin species. Hydrolyzes oxidized glycerophosphoethanolamines present in pancreatic islets, releasing oxidized polyunsaturated fatty acids such as hydroxyeicosatetraenoates (HETEs) (PubMed:24648512). Has thioesterase activity toward fatty-acyl CoA releasing CoA-SH known to facilitate fatty acid transport and beta-oxidation in mitochondria particularly in skeletal muscle (PubMed:18937505). Plays a role in regulation of membrane dynamics and homeostasis. Selectively hydrolyzes sn-2 arachidonoyl group in plasmalogen phospholipids, structural components of lipid rafts and myelin (By similarity). Regulates F-actin polymerization at the pseudopods, which is required for both speed and directionality of MCP1/CCL2-induced monocyte chemotaxis (By similarity). Targets membrane phospholipids to produce potent lipid signaling messenger…
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in pancreatic beta-cells (PubMed:9111008). Expressed in skeletal muscle (at protein level) (PubMed:18937505).
messages: Has two putative calmodulin binding domains, the 1-9-14 and IQ motifs (PubMed:11118454). One calmodulin molecule interacts with PLA2G6 dimer, likely through 1-9-14 motif on each monomer (By similarity). Binds calmodulin in a calcium-dependent way (PubMed:11118454).
messages: Homodimer formed by catalytic domains tightly interacting through a large hydrophobic interface. The contact area involves 3 alpha helices, several loops and a part of the beta sheet from each monomer. Both active sites of the dimer are in close proximity adopting an open conformation that provide sufficient space for phospholipid access and favoring cooperativity in deacylation-reacylation reactions. Each monomer has 9 ankyrin repeats stacked side-by-side in an elongated structure oriented outwards from the catalytic core.
messages: Mitochondrion
messages: pseudopodium

10116:Adra2b
gene id: 10116:Adra2b
uniprot id: A6HQ14
uniprot id: P19328
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
messages: Cell membrane
messages: Interacts with RAB26. Interacts with PPP1R9B. Interacts with GGA1, GGA2 and GGA3.
messages: Membrane

10116:Or14c40
gene id: 10116:Or14c40
uniprot id: A0A8I6A390
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Hba-a3
gene id: 10116:Hba-a3
uniprot id: A0A9K3Y8D0
uniprot id: Q63910
names: Similarity
messages: Belongs to the globin family.

10116:LOC312273
gene id: 10116:LOC312273
uniprot id: P32821
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: extracellular space

10116:Fgf2
gene id: 10116:Fgf2
uniprot id: A0A7U3JW58
uniprot id: P13109
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Also acts as an integrin ligand which is required for FGF2 signaling (By similarity). Binds to integrin ITGAV:ITGB3 (By similarity). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (By similarity). Functions as a potent mitogen in vitro (By similarity). Can induce angiogenesis (By similarity). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (By similarity).
messages: Belongs to the heparin-binding growth factors family.
messages: Found in all tissues examined.
messages: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP3. Interacts with integrin ITGAV:ITGB3; the interaction is required for FGF2 signaling. Interacts with SNORC (via the extracellular domain). Interacts with GPC3 (PubMed:9065409).
messages: Nucleus
messages: Phosphorylation at Tyr-81 regulates FGF2 unconventional secretion.
messages: Secreted

10116:Bpifc
gene id: 10116:Bpifc
uniprot id: A6IFC9
uniprot id: D4AD20
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

10116:Ripor2
gene id: 10116:Ripor2
uniprot id: A0A8I5Y5T3
uniprot id: A0A8I6AP27
uniprot id: A0A8I6GLY0
uniprot id: Q7TP54
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (By similarity). Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (By similarity). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear. Plays a role for maintaining the structural organization of the basal domain of stereocilia. Involved in mechanosensory hair cell function. Required for normal hearing (By similarity).
messages: Apical cell membrane
messages: Belongs to the RIPOR family.
messages: Cytoplasm
messages: Expressed in the cochlea (at protein level).
messages: Homooligomer; homooligomerization is regulated by RHOC and leads to the formation of concatemers through the association of N- and C-termini (By similarity). Interacts (phosphorylated form) with 14-3-3 proteins; these interactions occur during myogenic cell differentiation and also induces T cell proliferation arrest (By similarity). Interacts (phosphorylated form) with HDAC6; this interaction occurs during early myogenic differentiation, prevents HDAC6 to deacetylate tubulin and also induces T cell proliferation arrest (By similarity). Interacts with DYSF; this interaction occurs during early myogenic differentiation (By similarity). Interacts with MYOF (By similarity). Interacts (via active GTP- or inactive GDP-bound forms) with RHOA; this interaction is direct, blocks the loading of GTP to RHOA and decreases upon chemokine CCL19 stimulation in primary T lymphocytes. Interacts with RHOC (By similarity). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (By similarity). Interacts with YWHAE (By similarity). Interacts with YWHAQ (By similarity).
messages: Phosphorylated. Chemokine-induced phosphorylation in neutrophils occurs in a PKC- and AKT-dependent manner, resulting in RIPOR2 interaction with YWHAB and stabilization. Phosphorylated by PKCA, AKT1 and MAPKAPK1A; in vitro.
messages: cytoskeleton
messages: filopodium
messages: stereocilium
messages: stereocilium membrane

10116:LOC100364523
gene id: 10116:LOC100364523
uniprot id: A0A0G2K319
uniprot id: A6KAE2
names: Similarity
messages: Belongs to the peptidase C1 family.

10116:Prss16
gene id: 10116:Prss16
uniprot id: A0A0G2K1Q6
uniprot id: A6KNA8
names: Similarity
messages: Belongs to the peptidase S28 family.

10116:Tmem9b
gene id: 10116:Tmem9b
uniprot id: A6I7Z0
names: Similarity
messages: Belongs to the TMEM9 family.

10116:Urm1
gene id: 10116:Urm1
uniprot id: B6ID11
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm

10116:Nlrp9
gene id: 10116:Nlrp9
uniprot id: D3ZAD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NLRP family.
messages: Inflammasome

10116:Oprd1
gene id: 10116:Oprd1
uniprot id: P33533
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Detected in brain, brain stem and brain cortex.
messages: G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
messages: May form homooligomers. Forms a heterodimer with OPRM1. Interacts with GPRASP1. Interacts with RTP4; the interaction promotes cell surface localization of the OPRD1-OPRM1 heterodimer.
messages: Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.

10116:Mapk1
gene id: 10116:Mapk1
uniprot id: A6JSN9
uniprot id: P63086
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with ADAM15, ARHGEF2, DAPK1 (via death domain), HSF4, IER3, IPO7, MKNK2, MORG1, NISCH, PEA15, SGK1, and isoform 1 of NEK2 (By similarity). Interacts (via phosphorylated form) with TPR (via C-terminal region and phosphorylated form); the interaction requires dimerization of MAPK1/ERK2 and increases following EGF stimulation (By similarity). Interacts with MAP2K1 (By similarity). Interacts with DUSP6 (PubMed:16567630). Interacts with ARRB2 (PubMed:11226259). Interacts (phosphorylated form) with CAV2 ('Tyr-19'-phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation (PubMed:19778377, PubMed:19427337). MKNK2 isoform 1 binding prevents from dephosphorylation and inactivation (By similarity). Interacts with DCC (PubMed:21070949). The phosphorylated form interacts with PML (By similarity). Interacts with STYX (By similarity). Interacts with CDK2AP2 (PubMed:12944431). Interacts with CAVIN4 (PubMed:24567387). Interacts with DUSP7; the interaction enhances DUSP7 phosphatase activity (PubMed:27783954). Interacts with GIT1; this interaction is necessary for MAPK1 localization to focal adhesions (PubMed:15923189). Interacts with ZNF263 (By similarity).
messages: Cytoplasm
messages: Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme. Phosphorylated upon FLT3 and KIT signaling. Ligand-activated ALK induces tyrosine phosphorylation (By similarity). Dephosphorylated by PTPRJ at Tyr-185 (By similarity). Autophosphorylated on threonine and tyrosine residues in vitro, which correlates with a slow and low level of activation. Phosphorylation on Ser-27 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2 (By similarity). Dephosphorylated by DUSP1 and DUSP2 at Thr-183 and Tyr-185 (By similarity).
messages: Highest levels within the nervous system, expressed in different tissues, mostly in muscle, thymus and heart.
messages: ISGylated.
messages: Increased expression during development.
messages: Nucleus
messages: Phosphorylated by MAP2K1/MEK1 and MAP2K2/MEK2 on Thr-183 and Tyr-185 in response to external stimuli like insulin or NGF. Both phosphorylations are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Phosphorylation on Ser-27 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Dephosphorylated and inactivated by DUSP1, DUSP3, DUSP6 and DUSP9. Inactivated by pyrimidylpyrrole inhibitors.
messages: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1 and FXR1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substra…
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
messages: Ubiquitinated by TRIM15 via 'Lys-63'-linked ubiquitination; leading to activation. Deubiquitinated by CYLD.
messages: caveola
messages: centrosome
messages: focal adhesion
messages: spindle

10116:Prss58
gene id: 10116:Prss58
uniprot id: Q6IE06
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Secreted
messages: Thr-195 is present instead of the conserved Ser which is expected to be an active site residue. It is therefore unsure if this protein has kept its catalytic activity.

10116:Or4c123
gene id: 10116:Or4c123
uniprot id: A6HN33
uniprot id: D3ZQ39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Trpm5
gene id: 10116:Trpm5
uniprot id: A0A455XI77
names: Subcellular Location Annotation
messages: Membrane

10116:Hdc
gene id: 10116:Hdc
uniprot id: A0A9K3Y711
uniprot id: A1A5M4
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

10116:Dpcd
gene id: 10116:Dpcd
uniprot id: Q6AYM4
names: Function
names: Similarity
messages: Belongs to the DPCD family.
messages: May play a role in the formation or function of ciliated cells.

10116:Pip4p1
gene id: 10116:Pip4p1
uniprot id: A0A8I6GLH6
uniprot id: A6KEC3
uniprot id: Q5PPM8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (By similarity). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (By similarity). May play a role in the regulation of cellular cholesterol metabolism (By similarity).
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Cell membrane
messages: Endosome membrane
messages: Interacts (via transmembrane domain) with ATP6V0D1 (By similarity). Interacts with LAMTOR1, RRAGA and RRAGC (By similarity).
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

10116:Usb1
gene id: 10116:Usb1
uniprot id: A6JY12
uniprot id: Q5I0I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation. In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1.
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Interacts with PLRG1, CDC5L and PRPF19.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

10116:Hs6st1
gene id: 10116:Hs6st1
uniprot id: A6INC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

10116:Marchf11
gene id: 10116:Marchf11
uniprot id: A0A8I6GB48
uniprot id: A6P320
uniprot id: F1LSY5
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasmic vesicle membrane
messages: E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids.
messages: Interacts (YXXL motif) with AP1M1. Interacts (via PDZ-binding motif) with LIN7A. Interacts with unidentified fucose glycoproteins.
messages: Membrane
messages: Predominantly expressed in testis. Present in early developing spermatids. Not present in spermatogonia, spermatocytes or somatic cells (i.e. peritubular, Leydig, and Sertoli cells). Present in early round spermatids at step 4, remains until step 11, then it decreases at steps 12-15, and diminishes after step 16 (at protein level). Also expressed at lower level in brain.
messages: The RING-CH-type zinc finger domain is required for E3 ligase activity.

10116:Lrp2bp
gene id: 10116:Lrp2bp
uniprot id: Q569C2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with LRP2.
messages: May act as an adapter that regulates LRP2 function.

10116:Tmem126b
gene id: 10116:Tmem126b
uniprot id: B2RZD2
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I (PubMed:22982022). Participates in constructing the membrane arm of complex I (By similarity).
messages: Mitochondrion membrane
messages: Part of the mitochondrial complex I assembly/MCIA complex that comprises at least the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9 and complement subunits such as COA1 and TMEM186 (PubMed:22982022). Associates with the intermediate 370 kDa subcomplex of incompletely assembled complex I (By similarity). Interacts with TMEM70 (By similarity).
messages: Reduction in respiration by about two-thirds, only when the electrons were fed into complex I via the NADH-linked substrates malate and glutamate in ADP-stimulated mitochondria.

10116:Spa17
gene id: 10116:Spa17
uniprot id: A6KRK5
uniprot id: F7FLV9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

10116:Ak6
gene id: 10116:Ak6
uniprot id: Q5EB68
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: AK6 and TAF9 were initially considered as products of the same gene since they share two exons. However, they are translated from different initiation codons and reading frames and encode unrelated proteins. This arrangement is conserved in some mammalian species.
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

10116:Rngtt
gene id: 10116:Rngtt
uniprot id: A6IIL7
uniprot id: D3ZH30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus

10116:Tmem171
gene id: 10116:Tmem171
uniprot id: Q6K0P5
names: Subcellular Location Annotation
messages: Membrane

10116:Wnt11
gene id: 10116:Wnt11
uniprot id: A6I6F2
uniprot id: G3V819
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

10116:Becn1
gene id: 10116:Becn1
uniprot id: A6HJA4
uniprot id: Q91XJ1
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A homodimeric form is proposed to exist; this metastable form readily transits to ATG14- or UVRAG-containing complexes with BECN1:UVRAG being more stable than BECN1:ATG14 (PubMed:22314358). Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex the core of which is composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 associating with additional regulatory/auxilliary subunits to form alternative complex forms. Alternative complex forms containing a forth regulatory subunit in a mutually exclusive manner are PI3K complex I (PI3KC3-C1) containing ATG14, and PI3K complex II (PI3KC3-C2) containing UVRAG. PI3KC3-C1 displays a V-shaped architecture with PIK3R4 serving as a bridge between PIK3C3 and the ATG14:BECN1 subcomplex. Both, PI3KC3-C1 and PI3KC3-C2, can associate with further regulatory subunits, such as RUBCN, SH3GLB1/Bif-1 and AMBRA1. PI3KC3-C1 probably associates with PIK3CB. Interacts with AMBRA1, GOPC, GRID2. Forms a complex with PPP2CA and AMBRA1; AMBRA1 and BECN1 components of the complex regulate MYC stability via different pathways (By similarity). Interacts with BCL2 and BCL2L1 isoform Bcl-X(L); the interaction inhibits BECN1 function in promoting autophagy by interfering with the formation of the PI3K complex. Interacts with cytosolic HMGB1; inhibits the interaction of BECN1 and BCL2 leading to promotion of autophagy. Interacts with USP10, USP13, DAPK1, RAB39A. Interacts with SLAMF1 (By similarity). Interacts with the poly-Gln domain of ATXN3; the interaction causes deubiquitination at Lys-400 and stabilizes BECN1. Interacts with VMP1 (PubMed:17724469). Interacts with TRIM5; the interaction causes activation of BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (By similarity). Interacts with active ULK1 (phosphorylated on 'Ser-317') and MEFV simultaneously (By similarity). Interacts with WDR81 and WDR91; negatively regulates the PI3 kinase/PI3K activity associated with endosom…
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Expanded poly-Gln tracts inhibit ATXN3-BECN1 interaction, decrease BECN1 levels and impair starvation-induced autophagy (By similarity).
messages: Membrane
messages: Mitochondrion
messages: Mitochondrion membrane
messages: Nucleus
messages: Phosphorylation at Thr-117 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy. In response to autophagic stimuli, phosphorylated at serine residues by AMPK in an ATG14-dependent manner, and this phosphorylation is critical for maximally efficient autophagy.
messages: Plays a central role in autophagy.
messages: Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. May play a role in antiviral host defense (By similarity).
messages: Polyubiquitinated by NEDD4, both with 'Lys-11'- and 'Lys-63'-linkages (By similarity). 'Lys-11'-linked polyubiquitination leads to degradation and is enhanced when the stabilizing interaction partner VPS34 is depleted (By similarity). Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes (By similarity). Polyubiquitinated at Lys-400 with 'Lys-48'-linkages (By similarity). 'Lys-48'-linked polyubiquitination of Lys-400 leads to degradation (By similarity). Deubiquitinated by ATXN3, leading to stabilization (By similarity). Ubiquitinated at Lys-435 via 'Lys-63'-linkage by the DCX(AMBRA1) complex, thereby increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (By similarity). 'Lys-48'-linked ubiquitination by RNF216 leads to proteasomal degradation and autophagy inhibition (By similarity).
messages: Proteolytically processed by caspases including CASP8 and CASP3; the C-terminal fragments lack autophagy-inducing capacity and are proposed to induce apoptosis. Thus the cleavage is proposed to be an determinant to switch from autophagy to apoptosis pathways affecting cellular homeostasis including viral infections and survival of tumor cells.
messages: The C-terminal evolutionary conserved domain (ECD) contains poly-Gln-binding domains such as the ATXN3 poly-Gln motif, consistent with structural docking models revealing two highly scored poly-Gln-binding pockets in the ECD (By similarity). As some binding is observed with BECN1 lacking the ECD, other domains of BECN1 may also interact with ATXN3 (By similarity).
messages: The coiled coil domain can form antiparallel homodimers and mediates dimerization with the coiled coil domains of ATG14 or UVRAG involved in the formation of PI3K complexes.
messages: autophagosome
messages: trans-Golgi network membrane

10116:Mad2l2
gene id: 10116:Mad2l2
uniprot id: D3Z8D9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.
messages: Cytoplasm
messages: Homooligomer. Heterodimer with REV3L. This dimer forms the minimal DNA polymerase zeta complex (Pol-zeta2), with REV3L bearing DNA polymerase catalytic activity, although its activity is very low in this context. Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3; Pol-zeta4 is the fully active form of DNA polymerase zeta. Component of the shieldin complex, consisting of SHLD1, SHLD2, SHLD3 and MAD2L2/REV7. Within the complex, SHLD2 forms a scaffold which interacts with a SHLD3-MAD2L2 subcomplex via its N-terminus, and with SHLD1 via its C-terminus. Interacts with REV1. Interacts with ADAM9. Interacts with CHAMP1. Interacts with FZR1 (in complex with the anaphase promoting complex APC). May interact with CDC20. Interacts with RAN. Interacts with ELK1; the interaction is direct and recruits MAD2L2 to ELK1-specific promoters. May interact with the JNK kinases MAPK8 and/or MAPK9 to stimulate ELK1 phosphorylation and transcriptional activity upon DNA damage. Interacts with TCF7L2; prevents its binding to promoters and negatively modulates its transcriptional activity. Interacts with YY1AP1. Interacts with PRCC; the interaction is direct. Interacts with POGZ.
messages: Nucleus
messages: spindle

10116:Psma5
gene id: 10116:Psma5
uniprot id: F7FLA6
uniprot id: Q6P9V6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

10116:Tomm20
gene id: 10116:Tomm20
uniprot id: Q62760
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom20 family.
messages: Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases.
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOM22. Interacts with APEX1 (By similarity). Interacts with TBC1D21 (By similarity).
messages: Mitochondrion outer membrane
messages: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

10116:Prps1l1
gene id: 10116:Prps1l1
uniprot id: A6HB94
uniprot id: M0RBK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

10116:Hao1
gene id: 10116:Hao1
uniprot id: B0BNF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
messages: Broad substrate specificity (S)-2-hydroxy-acid oxidase that preferentially oxidizes glycolate. The glyoxylate produced by the oxidation of glycolate can then be utilized by alanine-glyoxylate aminotransferase for the peroxisomal synthesis of glycine; this pathway appears to be an important step for the detoxification of glyoxylate which, if allowed to accumulate, may be metabolized to oxalate with formation of kidney stones. Can also catalyze the oxidation of glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate. Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2.
messages: Homotetramer.
messages: Peroxisome matrix

10116:Taar6
gene id: 10116:Taar6
uniprot id: A6JUM7
uniprot id: Q923Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

10116:Selenoo
gene id: 10116:Selenoo
uniprot id: B2GVA1
names: Similarity
messages: Belongs to the SELO family.

10116:Zc3h18
gene id: 10116:Zc3h18
uniprot id: Q6TQE1
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with ZFC3H1 in a RNase-insensitive manner.
messages: Nucleus

10116:Myh7b
gene id: 10116:Myh7b
uniprot id: B6RK61
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

10116:Ctbp1
gene id: 10116:Ctbp1
uniprot id: A0A0H2UI20
uniprot id: A6IK67
uniprot id: Q6AZ26
uniprot id: Q9Z2F5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylated; when cells are exposed to brefeldin A.
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Cofactor binding induces a conformational change.
messages: Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.
messages: Cytoplasm
messages: Homo- or heterodimer. Heterodimer with CTBP2. Interacts with ELK3 (via its PXDLS motif). Interacts with RBBP8 (via its PXDLS motif); the interaction is disrupted by binding to adenovirus E1A. Interacts with PNN, MECOM and ZFHX1B. Interacts with ZNF366 (via PXDLS motif) (By similarity). Interaction with SATB1 (non-acetylated form); the interaction stabilizes its attachment to DNA and promotes transcription repression. Interacts with PRDM16; the interaction represses white adipose tissue (WAT)-specific genes expression. Interacts with GLIS2, HIPK2, FOXP1, FOXP2, HDAC4, HDAC5, HDAC9, NRIP1 and WIZ. Interacts with ZNF217. Interacts with BCL6; the interaction is required for BCL6 transcriptional autoinhibition and inhibition of some BCL6 target genes. Interacts with IKZF4 (By similarity). Interacts with MCRIP1 (unphosphorylated form, via the PXDLS motif); competitively inhibiting CTBP-ZEB1 interaction (By similarity). Interacts with Bassoon/BSN; this interaction targets and anchors CTBP1 to presynapses (PubMed:25652077). Interacts with SIMC1 (By similarity).
messages: Nucleus
messages: Sumoylation on Lys-418 is promoted by the E3 SUMO-protein ligase CBX4.
messages: The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-412 induces proteasomal degradation (By similarity).
messages: synaptosome

10116:Or8k22
gene id: 10116:Or8k22
uniprot id: A6HMW8
uniprot id: M0R4H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Lcn9
gene id: 10116:Lcn9
uniprot id: A6JTB1
uniprot id: F7FKU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

10116:Mdh1b
gene id: 10116:Mdh1b
uniprot id: A0A0G2JVU8
uniprot id: A6IPG9
uniprot id: D3Z861
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

10116:Susd3
gene id: 10116:Susd3
uniprot id: A0A8I5ZSB4
uniprot id: A6J6X1
uniprot id: D3Z8I2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Pcsk9
gene id: 10116:Pcsk9
uniprot id: A6JYM6
uniprot id: P59996
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S8 family.
messages: Cell surface
messages: Cleavage by furin and PCSK5 generates a truncated inactive protein that is unable to induce LDLR degradation.
messages: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Endosome
messages: Golgi apparatus
messages: Highly expressed in 12-day embryo. In the adult, strongly expressed in liver, small intestine, jejunum, and to a lesser extent in kidney, lung, spleen and thymus. Expression in the liver is up-regulated following partial hepatectomy.
messages: Its proteolytic activity is autoinhibited by the non-covalent binding of the propeptide to the catalytic domain. Inhibited by EGTA (By similarity).
messages: Lysosome
messages: Monomer. Can self-associate to form dimers and higher multimers which may have increased LDLR degrading activity. The precursor protein but not the mature protein may form multimers. Interacts with APOB, VLDLR, LRP8/APOER2 and BACE1. The full-length immature form (pro-PCSK9) interacts with SCNN1A, SCNN1B and SCNN1G. The pro-PCSK9 form (via C-terminal domain) interacts with LDLR. Interacts (via the C-terminal domain) with ANXA2 (via repeat Annexin 1); the interaction inhibits the degradation of LDLR.
messages: Phosphorylation protects the propeptide against proteolysis.
messages: Secreted
messages: The C-terminal domain (CRD) is essential for the LDLR-binding and degrading activities.
messages: The catalytic domain is responsible for mediating its self-association.
messages: Undergoes autocatalytic cleavage in the endoplasmic reticulum to release the propeptide from the N-terminus and the cleavage of the propeptide is strictly required for its maturation and activation. The cleaved propeptide however remains associated with the catalytic domain through non-covalent interactions, preventing potential substrates from accessing its active site. As a result, it is secreted from cells as a propeptide-containing, enzymatically inactive protein (By similarity).

10116:Timm22
gene id: 10116:Timm22
uniprot id: A6HGV6
uniprot id: Q9JKW1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral protein FXC1/TIMM10B and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10 (TIMM10A or TIMM10B). A small fraction of the 70 kDa complex is composed of TIMM8 (TIMM8A/DDP1 or TIMM8B/DDP2) and TIMM13. The TIM22 complex also contains AGK and TIMM29. Interacts directly with TIMM9, TIMM10A and FXC1/TIMM10B. Interacts (when oxidized) with TIMM29; interaction is direct.
messages: Component of the TIM22 complex.
messages: Disulfide bonds promote efficient assembly of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

10116:Sh2b1
gene id: 10116:Sh2b1
uniprot id: A6I961
uniprot id: A6I967
uniprot id: Q62985
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis (By similarity).
messages: Belongs to the SH2B adapter family.
messages: Cytoplasm
messages: Isoform 1 is ubiquitously expressed. Expressed in epididymal adipose tissue, liver and skeletal muscle.
messages: Membrane
messages: Nucleus
messages: Phosphorylated on tyrosine residues in response to treatment with growth hormone (GH), IFN-gamma (IFNG), BDNF, PDGF and FGF. Phosphorylated on tyrosine residues by JAK2 and JAK1. Phosphorylated on multiple serine and threonine residues in response to treatment with NGF. Phosphorylated on serine residues.
messages: Self-associates. Homopentamer. Forms a heteromultimeric complex with SH2B2. Interacts with SH2B2. Isoform 1 interacts via its SH2 domain with JAK2. Isoform 2 interacts via its SH2 domain and its N-terminus with JAK2; the SH2 domain is required for the major interaction with JAK2 phosphorylated on tyrosine residues; the N-terminus provides a low-affinity binding to JAK2 independent of JAK2 phosphorylation. Isoform 1 interacts via its SH2 domain with INSR; the interaction requires receptor activation. Isoform 1 interacts with IGF1R; the interaction requires receptor activation. Isoform 2 interacts via its SH2 domain with FGFR3. Isoform 2 interacts with RET; the interaction requires RET kinase activity. Isoform 2 interacts with RAC1. Isoform 2 interacts with PDGFRA and/or PDGFRB; the interaction requires receptor activation. Interacts with ISR1 and ISR2. Probably part of a complex consisting of INSR, ISR1 and SH2B1. Probably part of a ternary complex consisting of SH2B1, JAK2 and ISR1 or ISR2 (By similarity). May interact with FCER1G. Interacts (via SH2 domain) with NTRK1 (phosphorylated).

10116:Ptn
gene id: 10116:Ptn
uniprot id: A0A8I5ZQE2
uniprot id: A6IEP7
uniprot id: A6IEP8
uniprot id: P63090
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the pleiotrophin family.
messages: Expressed at low levels in the brain in early embryonic stages. Levels increase to a maximum before or just after birth, and are lower in adult brain (PubMed:1768439). At 16 dpc intensely expressed in the matrix of the developing cartilage and persists in the matrix of the mineralized cartilage at 20 dpc (at protein level). Localized within the unmineralized cartilage matrix (at mRNA level) (PubMed:9817766).
messages: Expressed in brain (PubMed:2170351). Hardly expressed in bone. Abundantly expressed in the growth plate. Intensely expressed in the cartilage matrix that forms the hollow for the secondary ossification center. Is expressed selectively by the osteocytes of the lamellar bone, whereas it is hardly expressed by those of the woven bone. Is detected in the matrix surrounding the osteocytes and in the canaliculi of the osteocytes. Is distributed on the surface of lamellar bone (PubMed:9817766).
messages: Interacts with ALK and NEK6 (By similarity). Interacts with PTPRZ1 (via chondroitin sulfate groups); promotes formation of homooligomers; oligomerization impairs tyrosine phosphatase activity (PubMed:16814777). Forms a complex with PTPRZ1 and CTNNB1; this complex inactivates PTPRZ1 protein tyrosine phosphatase activity through PTN interaction and stimulates tyrosine phosphorylation of CTNNB1. Interacts with ITGB3 and ITGA5. Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through ITGB3 'Tyr-773' phosphorylation (By similarity). Interacts with SDC3 (via heparan sulfate chains); this interaction mediates the neurite outgrowth-promoting signal from PTN to the cytoskeleton of growing neurites; this interaction mediates osteoblast recruitment (PubMed:8175719, PubMed:9817766). Interacts with GPC2 (via heparan sulfate); this interaction promotes neurite outgrowth through binding of PTN with chondroitin sulfate of proteoglycans, thereby releasing PTPRS of chondroitin sulfate proteoglycans (CSPGs) and leading to binding with heparan sulfate of GPC2 (PubMed:27671118).
messages: Phosphorylated by NEK6.
messages: Secreted
messages: Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:16814777, PubMed:27671118, PubMed:9817766). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (PubMed:27671118, PubMed:9817766). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK or AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:16814777). Through PTPRZ1 binding, regulates endothelial cell migration and controls oligodendrocyte precursor cell differentiation (By similarity). Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation (By similarity). In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (By similarity). Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion (PubMed:27671118). Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (PubMed:9817766). Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (By similarity). Inhibi…

10116:Hsbp1l1
gene id: 10116:Hsbp1l1
uniprot id: D4A9E1
names: Similarity
messages: Belongs to the HSBP1 family.

10116:Spata20
gene id: 10116:Spata20
uniprot id: A6HI51
uniprot id: Q6T393
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Detected at age 28 days and was most abundant at age 63 days. No expression at 21 days, seems therefore to be expressed in spermatids and not in spermatocytes or spermatogonia of the germ cells.
messages: May play a role in fertility regulation.
messages: Secreted
messages: Testis-specific and age-dependent (at protein level). Highly expressed. Expressed in round spermatids located in the inner half-layer of the seminiferous epithelium as well as in early elongated spermatids having cytoplasmic protrusions into the tubular lumen.

10116:Mmp15
gene id: 10116:Mmp15
uniprot id: A6JY10
uniprot id: D3ZCG5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

10116:Caln1
gene id: 10116:Caln1
uniprot id: Q06BI3
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Brain-specific. High expression in the cerebellum, hippocampus, and cortex.
messages: Calcium binding induces conformational changes in CALN1/CABP8. The calcium binding affinity is not regulated by magnesium.
messages: Cell membrane
messages: Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner.
messages: Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning.
messages: The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.
messages: perinuclear region
messages: trans-Golgi network membrane

10116:Sem1
gene id: 10116:Sem1
uniprot id: A6IDU4
uniprot id: D3ZHW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSS1/SEM1 family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Nucleus

10116:Vom2r12
gene id: 10116:Vom2r12
uniprot id: A0A0G2JZW0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Oaf
gene id: 10116:Oaf
uniprot id: A6J3U0
uniprot id: Q6AYE5
names: Similarity
messages: Belongs to the OAF family.

10116:Grin2d
gene id: 10116:Grin2d
uniprot id: Q62645
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter.
messages: Already detected in embryonic stages, peaks at postnatal day 7, and decreases thereafter to adult levels.
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily.
messages: Cell membrane
messages: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7512349, PubMed:21522138, PubMed:23625947). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:7512349, PubMed:23625947).
messages: Expressed in brain, mainly in the subcortical region.
messages: Heterotetramer. Forms heterotetrameric channels composed of two zeta subunits (GRIN1), and two epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) (in vitro) (PubMed:21522138, PubMed:23625947). In vivo, the subunit composition may depend on the expression levels of the different subunits (Probable). Interacts with PDZ domains of PATJ and DLG4 (PubMed:7569905, PubMed:9647694).
messages: Postsynaptic cell membrane

10116:Olr1149
gene id: 10116:Olr1149
uniprot id: A0A0G2K469
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Aars2
gene id: 10116:Aars2
uniprot id: D3ZX08
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Mitochondrion
messages: Monomer.

10116:Edem2
gene id: 10116:Edem2
uniprot id: A6KI53
uniprot id: F7FAW8
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

10116:Vom2r8
gene id: 10116:Vom2r8
uniprot id: A0A8I5Y715
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Nae1
gene id: 10116:Nae1
uniprot id: A1L122
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

10116:Bcl10
gene id: 10116:Bcl10
uniprot id: Q9QYN5
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Homomultimer; homooligomerized following recruitment by CARD domain-containing proteins that form a nucleating helical template that recruits BCL10 via CARD-CARD interaction. Self-associates by CARD-CARD interaction and interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Forms a complex with CARD14 and MALT1; resulting in the formation of a CBM (CARD14-BCL10-MALT1) complex. Forms a complex with CARD11 and MALT1; resulting in the formation of a CBM (CARD11-BCL10-MALT1) complex (By similarity). Forms a complex with CARD9 and MALT1; resulting in the formation of a CBM (CARD9-BCL10-MALT1) complex (By similarity). Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2 (By similarity). Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive (By similarity).
messages: Membrane raft
messages: Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Phosphorylated by IKBKB/IKKB.
messages: Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation. Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex. This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity. Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK.
messages: Proteolytically cleaved by MALT1; required for T-cell activation.
messages: Ubiquitinated via both 'Lys-63'-linked and linear ('Met-1'-linked) polyubiquitin chains in response to T-cell receptor (TCR) activation. Ubiquitination is recognized by IKBKG/NEMO, the regulatory subunit of I-kappa-B kinase (IKK), and is required for TCR-induced NF-kappa-B activation. Linear ubiquitination at Lys-17, Lys-31 and Lys-63 is mediated by RNF31/HOIP; linear ubiquitination is recognized with much higher affinity than 'Lys-63'-linked ubiquitin by IKBKG/NEMO. CARD11 is required for linear ubiquitination by HOIP by promoting the targeting of BCL10 to RNF31/HOIP.
messages: perinuclear region

10116:Vom2r28
gene id: 10116:Vom2r28
uniprot id: D4ADJ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Hps6
gene id: 10116:Hps6
uniprot id: A6JHK5
uniprot id: Q7M733
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1) (By similarity). Interacts with AP-3 complex (PubMed:19010779). Interacts with DCTN1 and dynein intermediate chain (By similarity).
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.
messages: Early endosome membrane
messages: Lysosome membrane
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Acts as cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning.
messages: Microsome membrane
messages: cytosol

10116:Tmem100
gene id: 10116:Tmem100
uniprot id: Q569C0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Interacts (via C-terminus) with TRPA1 and TRPV1 (By similarity). Interacts with TASOR (By similarity).
messages: Membrane
messages: Perikaryon
messages: Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.
messages: perinuclear region

10116:Crisp3
gene id: 10116:Crisp3
uniprot id: P12020
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CRISP family.
messages: By androgens.
messages: Secreted
messages: Secreted by the epididymal epithelium and then becomes associated with the sperm surface.
messages: The N-terminus is blocked.
messages: This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens.
messages: Two major variant protein D and E differ from each other by their carbohydrate side chains.

10116:F3
gene id: 10116:F3
uniprot id: Q66HI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.
messages: Membrane

10116:Fam220a
gene id: 10116:Fam220a
uniprot id: Q6DGF6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with STAT3.
messages: May negatively regulate STAT3.
messages: Nucleus

10116:Defb10
gene id: 10116:Defb10
uniprot id: Q32ZI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

10116:Fam83h
gene id: 10116:Fam83h
uniprot id: A6HS48
uniprot id: D3ZRK0
names: Similarity
messages: Belongs to the FAM83 family.

10116:Timm8a2
gene id: 10116:Timm8a2
uniprot id: A6HUL0
uniprot id: D3ZV76
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

10116:Otog
gene id: 10116:Otog
uniprot id: A6JBB7
uniprot id: D3ZCV6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Or5ae1
gene id: 10116:Or5ae1
uniprot id: A0A8I6AM62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ppp4r2
gene id: 10116:Ppp4r2
uniprot id: B2RZ73
names: Similarity
messages: Belongs to the PPP4R2 family.

10116:Fermt1
gene id: 10116:Fermt1
uniprot id: A6HQH7
uniprot id: D3ZTV0
names: Similarity
messages: Belongs to the kindlin family.

10116:RGD1564492
gene id: 10116:RGD1564492
uniprot id: A0A8I5ZRE4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network
messages: perinuclear region

10116:Ndufa10l1
gene id: 10116:Ndufa10l1
uniprot id: A0A1W2Q6F8
uniprot id: Q561S0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Binds 1 FAD per subunit.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Expressed in the head and flagellum of epididymal sperm but not in testicular sperm (at protein level).
messages: Mitochondrion matrix
messages: Phosphorylation at Ser-250 by PINK1 is required for the binding and/or reduction of the complex I substrate ubiquinone.

10116:Cyb561
gene id: 10116:Cyb561
uniprot id: B5DFI2
names: Subcellular Location Annotation
messages: Membrane

10116:Oxsr1
gene id: 10116:Oxsr1
uniprot id: A6I3V9
uniprot id: D3ZUC9
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

10116:Olr1156
gene id: 10116:Olr1156
uniprot id: A0A8I5ZJ98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Pdia2
gene id: 10116:Pdia2
uniprot id: A0A8I6A0T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

10116:RT1-A2
gene id: 10116:RT1-A2
uniprot id: Q6MGB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Involved in the presentation of foreign antigens to the immune system.
messages: Membrane

10116:Olr1206
gene id: 10116:Olr1206
uniprot id: A0A096MK69
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Calhm3
gene id: 10116:Calhm3
uniprot id: D4A158
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

10116:Rab26
gene id: 10116:Rab26
uniprot id: P51156
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Expressed in pancreas, kidney, brain, submandibular gland, and lung.
messages: Golgi apparatus membrane
messages: Interacts with ADRA2B. Interacts with RIMS1 (By similarity).
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (By similarity). Plays a role in the secretion of amylase from acinar granules in the parotid gland.
messages: secretory vesicle membrane

10116:Prdx1
gene id: 10116:Prdx1
uniprot id: A6JZ89
uniprot id: Q63716
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family.
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer; disulfide-linked, upon oxidation (PubMed:10535922). 5 homodimers assemble to form a ring-like decamer (PubMed:17974571). Interacts with GDPD5; forms a mixed-disulfide with GDPD5 (By similarity). Interacts with SESN1 and SESN2 (By similarity). Interacts with FAM107A (By similarity).
messages: Phosphorylated on Thr-90 during the M-phase, which leads to a decrease in enzymatic activity.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).

10116:Kidins220
gene id: 10116:Kidins220
uniprot id: Q9EQG6
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in developing nervous system and in highly plastic areas of the adult brain. Also expressed in neuroendocrine cells, where it concentrates at the tip of neurites. Expressed in developing muscle and is concentrated at the neuromuscular junction (NMS). SNTA1 can regulate its localization in the NMS.
messages: Expressed in postmitotic neurons during the stage of development in which extensive axon pathfinding is occurring. At 14 dpc, expressed in both spinal cord and dorsal root ganglia. Present on the sarcolemma in postnstal day 1 (P1) gastrocnemius muscle. By P8, becomes more concentrated at the junctional sites and by P21, colocalizes with acetylcholine receptor clusters.
messages: Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a nerve growth factor (NGF)-dependent manner (PubMed:17724123). Interacts with RAPGEF2; the interaction is strengthened after NGF stimulation (PubMed:17724123). Isoform 2 interacts (via C-terminal domain) with MAGI2 isoform 1 (via PDZ domain) (PubMed:17724123). Interacts with NTRK1, NTRK2, NTRK3, ERKL and NGFR (PubMed:11150334, PubMed:15167895, PubMed:15378608). Can form a ternary complex with NGFR and NTRK1 and this complex is affected by the expression levels of KIDINS220/ARMS (PubMed:15378608). An increase in KIDINS220/ARMS expression leads to a decreased association of NGFR and NTRK1 (PubMed:15378608). Interacts (via PDZ-binding motif) with SNTA1 and SNTB2 (via PDZ domains) (PubMed:15939763). Interacts with EPHA4 and PRKD1 (PubMed:10998417, PubMed:15939763).
messages: Late endosome
messages: Membrane
messages: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration.
messages: The transmembrane domain mediates interaction with NTRK1.
messages: Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF).

10116:Fmod
gene id: 10116:Fmod
uniprot id: P50609
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity).
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds keratan sulfate chains.
messages: Binds to type I and type II collagen.
messages: extracellular matrix

10116:Ap3d1
gene id: 10116:Ap3d1
uniprot id: B5DFK6
uniprot id: F7F0K5
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

10116:Or52e3
gene id: 10116:Or52e3
uniprot id: A6I790
uniprot id: D4AA74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ctxn1
gene id: 10116:Ctxn1
uniprot id: P41237
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cortexin family.
messages: May mediate extracellular or intracellular signaling of cortical neurons during forebrain development.
messages: Membrane
messages: Neuron specific.

10116:Olr1139
gene id: 10116:Olr1139
uniprot id: D4AB09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Map3k13
gene id: 10116:Map3k13
uniprot id: A6JS67
uniprot id: F7FMK8
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

10116:Krtcap3
gene id: 10116:Krtcap3
uniprot id: A6HA63
uniprot id: Q497B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

10116:Wif1
gene id: 10116:Wif1
uniprot id: A6IGZ2
uniprot id: A6IGZ3
uniprot id: Q6IN38
names: Caution
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Induced during the differentiation of CG-4 cells.
messages: Interacts with MYOC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

10116:Mapkap1
gene id: 10116:Mapkap1
uniprot id: Q6AYF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIN1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Nucleus
messages: Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts with ATF2, MAP3K2 and MAPK8. Interacts with GTP-bound HRAS and KRAS. Interacts with IFNAR2, NBN and SGK1. Interacts with CCDC28B (By similarity).
messages: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-421'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (By similarity).

10116:Uqcrc2
gene id: 10116:Uqcrc2
uniprot id: A6I8R0
uniprot id: P32551
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M16 family.
messages: Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with RAB5IF (By similarity). Interacts with STMP1 (By similarity).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties. May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (By similarity).
messages: Expressed in the head region and flagellum of epididymal sperm.
messages: Mitochondrion inner membrane

10116:Gpt2
gene id: 10116:Gpt2
uniprot id: A0A8I6ARL0
uniprot id: A6KDD7
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

10116:Adad1
gene id: 10116:Adad1
uniprot id: Q3KR54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADAD family.
messages: Nucleus
messages: Required for male fertility and normal male germ cell differentiation (By similarity). Plays a role in spermatogenesis (By similarity). Binds to RNA but not to DNA (By similarity).

10116:Malsu1
gene id: 10116:Malsu1
uniprot id: A6K0K3
uniprot id: D3ZZ37
names: Similarity
messages: Belongs to the Iojap/RsfS family.

10116:Papolb
gene id: 10116:Papolb
uniprot id: Q6AYH1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

10116:Or4c58
gene id: 10116:Or4c58
uniprot id: D3Z928
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Grm6
gene id: 10116:Grm6
uniprot id: A6HE28
uniprot id: P35349
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.
messages: Golgi apparatus membrane
messages: Homodimer (By similarity). Interacts with GPR179 (By similarity).
messages: Membrane
messages: Restricted expression in the inner nuclear layer of the retina.
messages: dendrite

10116:Klrg1
gene id: 10116:Klrg1
uniprot id: Q64335
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases, PTPN11 and INPP5D.
messages: Expressed in lung mast cells.
messages: Forms a monomer and homodimer; disulfide-linked. Interacts (via ITIM motif) with PTPN11 and INPP5D (By similarity).
messages: Phosphorylated in response to monoclonal antibody G63 binding and antigenic stimulation.
messages: Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells (By similarity).

10116:Slc16a2
gene id: 10116:Slc16a2
uniprot id: Q8K1P8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Expressed at highest levels in liver, lower levels in brain, kidney and heart (at protein level) (PubMed:12871948). Expressed in microvessels of the blood-brain barrier (BBB) (at protein level) (PubMed:18687783).
messages: Monomer (By similarity). Homodimer (By similarity). Homooligomer (By similarity).
messages: Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormone across the cell membrane independently of pH or a Na(+) gradient. Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2) (PubMed:12871948). Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (By similarity).

10116:Flot2
gene id: 10116:Flot2
uniprot id: A0A0G2JXA8
uniprot id: A6HH00
uniprot id: A6HH01
uniprot id: A6HH03
uniprot id: Q5XIW9
uniprot id: Q9Z2S9
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Brain, retina and skin.
messages: By optic nerve injury.
messages: Cell membrane
messages: Endosome
messages: Expressed during embryogenesis, postnatal stages and in adult.
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS (By similarity).
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: Heterooligomeric complex.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: May play a role in axon growth and regeneration. May be involved in epidermal cell adhesion and epidermal structure and function.
messages: Membrane
messages: Membrane raft
messages: ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells.
messages: caveola

10116:Gpr63
gene id: 10116:Gpr63
uniprot id: A6IIH2
uniprot id: D3ZNT8
names: Subcellular Location Annotation
messages: Membrane

10116:Slc39a4
gene id: 10116:Slc39a4
uniprot id: A0JPN2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Expressed in duodenum, jejunum, and ileum.
messages: Glycosylated.
messages: Homodimer; homodimerization is mediated by the transmembrane domain.
messages: Recycling endosome membrane
messages: Selective transporter that mediates the uptake of Zn(2+). Plays an essential role for dietary zinc uptake from small intestine (By similarity). The Zn(2+) uniporter activity is regulated by zinc availability. Exhibits also polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (By similarity).
messages: The extracellular N-terminal ectodomain is cleaved when cells are Zn(2+) deficient, N-terminally cleaved SLC39A4 is internalized at a faster rate.
messages: The two metal binding sites M1 and M2 that are halfway through the membrane form a binuclear metal center. M1 is essential to Zn(2+) transport, while the other, M2 appears to have an auxiliary role presumably by acting as an additional transport site that can modulate the properties of the primary transport site. The binuclear metal center plays a key role in zinc sensing.
messages: Under excess Zn(2+) conditions, SLC39A4 on the cell surface is rapidly endocytosed, ubiquitinated and degraded.

10116:Ngrn
gene id: 10116:Ngrn
uniprot id: A6JC92
uniprot id: Q3T1H2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Nucleus
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.
messages: Secreted

10116:Elovl2
gene id: 10116:Elovl2
uniprot id: D4A612
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL2 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

10116:Galr1
gene id: 10116:Galr1
uniprot id: A6K5J0
uniprot id: Q62805
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
messages: Spinal cord, small intestine, Rin14B insulinoma cells and several brain regions, particularly ventral hippocampus, amygdala, supraoptic nucleus, hypothalamus, thalamus, lateral parabrachial nucleus and locus coeruleus.
messages: Three cysteine residues are found in the C-terminus, at least one of which may be palmitoylated.

10116:Fam83c
gene id: 10116:Fam83c
uniprot id: A6KI64
uniprot id: M0R501
names: Similarity
messages: Belongs to the FAM83 family.

10116:Rgs18
gene id: 10116:Rgs18
uniprot id: Q4L0E8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha (By similarity).

10116:Erh
gene id: 10116:Erh
uniprot id: A0A8I5ZSD4
uniprot id: A0A8I6AFK4
uniprot id: A6JDI9
uniprot id: B2RYQ5
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

10116:Smpd2
gene id: 10116:Smpd2
uniprot id: A6K715
uniprot id: Q9ET64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neutral sphingomyelinase family.
messages: Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor).
messages: Membrane

10116:Slc35b2
gene id: 10116:Slc35b2
uniprot id: A6JIZ3
uniprot id: Q2PGY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

10116:Acvr1b
gene id: 10116:Acvr1b
uniprot id: A6KCN3
uniprot id: P80202
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activin receptor type-2 (ACVR2A or ACVR2B) activates the type-1 receptor through phosphorylation of its regulatory GS domain.
messages: Autophosphorylated. Phosphorylated by activin receptor type-2 (ACVR2A or ACVR2B) in response to activin-binding at serine and threonine residues in the GS domain. Phosphorylation of ACVR1B by activin receptor type-2 regulates association with SMAD7 (By similarity).
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Forms an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B) (By similarity). Part of a complex consisting of MAGI2/ARIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). Interacts with SMAD2 and SMAD3 (By similarity). Interacts with SMAD7 (By similarity). Interacts with FKBP1A (By similarity). Interacts with IGSF1 (By similarity). Interacts with CRIPTO (By similarity). Interacts with TDP2 (By similarity). Interacts with TSC22D1/TSC-22 (By similarity).
messages: Membrane
messages: The GS domain is a 30-amino-acid sequence adjacent to the N-terminal boundary of the kinase domain and highly conserved in all other known type-1 receptors but not in type-2 receptors. The GS domain is the site of activation through phosphorylation by the II receptors (By similarity).
messages: Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2 (By similarity).
messages: Ubiquitinated.
messages: Ubiquitinated. Level of ubiquitination is regulated by the SMAD7-SMURF1 complex (By similarity).
messages: Urogenital ridge, testis, ovary, brain and lungs.

10116:Nudt5
gene id: 10116:Nudt5
uniprot id: Q6AY63
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
messages: Homodimer. Interacts with PARG.
messages: Nucleus
messages: Phosphorylation at Thr-45 is required for homodimer stability; dephosphorylation results in destabilization of the homodimer. Dephosphorylation at Thr-45 promotes the ATP-synthesis activity.

10116:Aadacl2fm2
gene id: 10116:Aadacl2fm2
uniprot id: M0R509
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

10116:Serpinb10
gene id: 10116:Serpinb10
uniprot id: Q8K3K4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: Cytoplasm
messages: Expressed in many tissues, including brain, heart, kidney, liver, lung, prostate, skin, spleen and stomach.
messages: Nucleus
messages: Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus (By similarity). Inhibits plasmin.

10116:Ywhah
gene id: 10116:Ywhah
uniprot id: A6IK71
uniprot id: P68511
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity).
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Weakly interacts with CDKN1B. Interacts with ARHGEF28 and CDK16. Interacts with GAB2 (By similarity). Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1 (By similarity). Interacts with the 'Ser-241' phosphorylated form of PDPK1 (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with SLITRK1 (By similarity). Interacts with MEFV (By similarity).
messages: Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.

10116:Phgdh
gene id: 10116:Phgdh
uniprot id: A6K3D6
uniprot id: O08651
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Does not catalyze the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.
messages: Homotetramer.
messages: Liver, kidney, brain, testis.

10116:Mycs
gene id: 10116:Mycs
uniprot id: P23999
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Has apoptosis-inducing activity.
messages: Nucleus

10116:Cyp21a1
gene id: 10116:Cyp21a1
uniprot id: F1LRG0
names: Similarity
messages: Belongs to the cytochrome P450 family.

10116:Fgd1
gene id: 10116:Fgd1
uniprot id: A0A8I6AC87
uniprot id: A6KL97
names: Subcellular Location Annotation
messages: cytoskeleton

10116:Utp14a
gene id: 10116:Utp14a
uniprot id: Q499R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

10116:Farsa
gene id: 10116:Farsa
uniprot id: A6IY66
uniprot id: Q505J8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Cytoplasm
messages: Heterotetramer; dimer of two heterodimers formed by FARSA and FARSB.

10116:Kif7
gene id: 10116:Kif7
uniprot id: D4A9P0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

10116:Ptcra
gene id: 10116:Ptcra
uniprot id: P0C6B3
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Found in CD45+ but not in the CD45- fetal liver cells.
messages: Heterodimer with TCRB; disulfide linked. This heterodimer assembles with CD3 proteins into a signaling-competent pre-T-cell receptor complex. Interacts with RHBDD1 (By similarity).
messages: Membrane
messages: The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.

10116:Or2ad1
gene id: 10116:Or2ad1
uniprot id: A6KN63
uniprot id: F1M2D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Gtf2a2
gene id: 10116:Gtf2a2
uniprot id: A6KEU8
uniprot id: O08950
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity).
messages: TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). Interacts with NCOA6 general coactivator. TFIIA forms a complex with TBP. Interacts with HSF1 (via transactivation domain). Interacts with HSF1 (via transactivation domain). Interacts with HSF1 (via transactivation domain).

10116:Cct8l2
gene id: 10116:Cct8l2
uniprot id: M0RBH2
uniprot id: Q3B7U6
names: Function
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.

10116:Dear
gene id: 10116:Dear
uniprot id: D3ZGZ6
names: Caution
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a dual endothelin-1/angiotensin-2 receptor only in the Dahl salt-sensitive strain (PubMed:15561758). In the Dahl salt-resistant strain and in other species including human and mouse, functions as a dual endothelin-1/VEGF signal peptide receptor and does not act as an angiotensin-2 receptor (PubMed:15561758).
messages: Cell membrane
messages: In the Dahl salt-resistant strain, acts as a dual receptor for both endothelin-1 and the signal sequence of vascular endothelial growth factor A and does not act as a receptor for angiotensin-2 (PubMed:15561758). Does not bind the VEGFA mature protein (By similarity). In the Dahl salt-sensitive strain, acts as a dual endothelin-1/angiotensin-2 receptor that is functionally coupled to a calcium-mobilizing transduction system, responding equivalently to both endothelin-1/EDN1 and angiotensin-2 peptides in a highly specific manner (PubMed:9508787, PubMed:15561758). May play a role in angiogenesis with a significant role in cardiovascular and neural development (By similarity).
messages: Prominently expressed in brain and heart tissues. Weakly expressed in aorta, adrenal gland, and lung tissues.

10116:Spsb3
gene id: 10116:Spsb3
uniprot id: A6HCY2
names: Function
names: Similarity
messages: Belongs to the SPSB family.
messages: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

10116:Errfi1
gene id: 10116:Errfi1
uniprot id: A6IUE1
uniprot id: P05432
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MIG6 family.
messages: By cAMP, glucocorticoids, phorbol esters and insulin.
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with EGFR and ERBB2.
messages: Membrane
messages: Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity).
messages: Nucleus
messages: The EGFR-binding region prevents binding of a cyclin-like activator to the EGFR kinase domain, and thereby keeps EGFR in an inactive conformation. Also maintains EGFR in an inactive conformation by preventing formation of an asymmetric homodimer (By similarity).

10116:P4ha1
gene id: 10116:P4ha1
uniprot id: A0A8I6ASU1
uniprot id: A6K3U5
uniprot id: A6K3U6
uniprot id: P54001
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P4HA family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen
messages: Heterotetramer of two alpha-1 chains and two beta chains (P4HB)(the beta chain is the multi-functional PDI), where P4HB plays the role of a structural subunit; this tetramer catalyzes the formation of 4-hydroxyproline in collagen.

10116:Or51b6
gene id: 10116:Or51b6
uniprot id: A6I7C7
uniprot id: D3ZTS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Nuak2
gene id: 10116:Nuak2
uniprot id: Q66HE5
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Tissue Specificity
messages: Activated by phosphorylation on Thr-212 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Expressed in liver, skin, testis, uterus, ovary, adrenal gland and brain (at protein level). Expressed in kidney, heart, skin, spleen, lung, uterus, liver and the exocrine and endocrine compartments of the human pancreas. A kinase-inactive isoform also appears to be expressed in the skin, spleen, lung, uterus, liver and testis.
messages: Phosphorylated at Thr-212 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Autophosphorylation is also possible at Thr-212.
messages: Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway.

10116:Sema6c
gene id: 10116:Sema6c
uniprot id: A6K2V3
uniprot id: Q9WTL3
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the semaphorin family.
messages: Cell membrane
messages: Detected at 12 dpc and found at markedly increased levels at 15 dpc and 18 dpc in both the head and the body. At birth the level decreases significantly.
messages: Expressed in many regions of the developing nervous system, probably in neurons and their precursors, but also in nonneural tissue such as immature muscle and dermis. In adult, strong expression in the skeletal muscle and moderate expression in the brain, where cerebellum shows the highest expression. Also expressed in almost all areas of the CNS.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.

10116:Slc35e4
gene id: 10116:Slc35e4
uniprot id: Q5RKL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35E subfamily.
messages: Membrane
messages: Putative transporter.

10116:Foxo1
gene id: 10116:Foxo1
uniprot id: G3V7R4
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Acetylation at Lys-256 and Lys-268 are necessary for autophagic cell death induction. Deacetylated by SIRT2 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagic cell death. Once in the nucleus, acetylated by CREBBP/EP300. Acetylation diminishes the interaction with target DNA and attenuates the transcriptional activity. It increases the phosphorylation at Ser-250. Deacetylation by SIRT1 results in reactivation of the transcriptional activity. Oxidative stress by hydrogen peroxide treatment appears to promote deacetylation and uncoupling of insulin-induced phosphorylation. By contrast, resveratrol acts independently of acetylation. Acetylated at Lys-417, promoting its localization to the nucleus and transcription factor activity. Deacetylation at Lys-417 by SIRT6, promotes its translocation into the cytoplasm, preventing its transcription factor activity. Deacetylation and subsequent inhibition by SIRT6 has different effects depending on cell types: it inhibits gluconeogenesis in hepatocytes, promotes glucose sensing in pancreatic beta-cells and regulates lipid catabolism in brown adipocytes.
messages: Acetylation at Lys-256 and Lys-268 are necessary for autophagic cell death induction. Deacetylated by SIRT2 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagic cell death. Once in the nucleus, acetylated by CREBBP/EP300. Acetylation diminishes the interaction with target DNA and attenuates the transcriptional activity. It increases the phosphorylation at Ser-250. Deacetylation by SIRT1 results in reactivation of the transcriptional activity. Oxidative stress by hydrogen peroxide treatment appears to promote deacetylation and uncoupling of insulin-induced phosphorylation. By contrast, resveratrol acts independently of acetylation (By similarity).
messages: Cytoplasm
messages: Interacts with LRPPRC. Interacts with RUNX2; the interaction inhibits RUNX2 transcriptional activity and mediates the IGF1/insulin-dependent BGLAP expression in osteoblasts Interacts with PPP2R1A; the interaction regulates the dephosphorylation of FOXO1 at Thr-24 and Ser-250 leading to its nuclear import. Interacts with NLK. Interacts with SIRT1; the interaction results in the deacetylation of FOXO1 leading to activation of FOXO1-mediated transcription of genes involved in DNA repair and stress resistance. Binds to CDK1. Interacts with the 14-3-3 proteins, YWHAG and YWHAZ; the interactions require insulin-stimulated phosphorylation on Thr-24, promote nuclear exit and loss of transcriptional activity. Interacts with SKP2; the interaction ubiquitinates FOXO1 leading to its proteasomal degradation. The interaction requires the presence of KRIT1. Interacts (via the C-terminal half) with ATF4 (via its DNA binding domain); the interaction occurs in osteoblasts, regulates glucose homeostasis via suppression of beta-cell proliferation and subsequent decrease in insulin production. Interacts with PRMT1; the interaction methylates FOXO1, prevents PKB/AKT1 phosphorylation and retains FOXO1 in the nucleus. Interacts with EP300 and CREBBP; the interactions acetylate FOXO1. Interacts with SIRT2; the interaction is disrupted in response to oxidative stress or serum deprivation, leading to increased level of acetylated FOXO1, which promotes stress-induced autophagy by stimulating E1-like activating enzyme ATG7. Interacts (acetylated form) with ATG7; the interaction is increased in response to oxidative stress or serum deprivation and promotes the autophagic process leading to cell death. Interacts (acetylated form) with PPARG. Interacts with XBP1; this interaction is direct and leads to FOXO1 ubiquitination and degradation via the proteasome pathway (By similarity). Interacts (via the Fork-head domain) with CEBPA; the interaction increases when FOXO1 is deacetylated. Interacts with…
messages: Methylation inhibits AKT1-mediated phosphorylation at Ser-250 and is increased by oxidative stress.
messages: Nucleus
messages: Phosphorylation by NLK promotes nuclear export and inhibits the transcriptional activity. In response to growth factors, phosphorylation on Thr-24, Ser-250 and Ser-313 by PKB/AKT1 promotes nuclear export and inactivation of transactivational activity. Phosphorylation on Thr-24 is required for binding 14-3-3 proteins. Phosphorylation of Ser-250 decreases DNA-binding activity and promotes the phosphorylation of Thr-24 and Ser-313, permitting phosphorylation of Ser-316 and Ser-319, probably by CDK1, leading to nuclear exclusion and loss of function. Stress signals, such as response to oxygen or nitric oxide, attenuate the PKB/AKT1-mediated phosphorylation leading to nuclear retention. Phosphorylation of Ser-323 is independent of IGF1 and leads to reduced function. Dephosphorylated on Thr-24 and Ser-250 by PP2A in beta-cells under oxidative stress leading to nuclear retention. Phosphorylation of Ser-243 by CDK1 disrupts binding of 14-3-3 proteins leading to nuclear accumulation and has no effect on DNA binding nor transcriptional activity. Phosphorylation by STK4/MST1 on Ser-206, upon oxidative stress, inhibits binding to 14-3-3 proteins and nuclear export (By similarity). PPIA/CYPA promotes its dephosphorylation on Ser-250 (By similarity).
messages: Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (By similarity). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin (By similarity). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (By similarity). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (By similarity). Promotes neural cell death (By similarity). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (B…
messages: Ubiquitinated by SKP2. Ubiquitination leads to proteasomal degradation (By similarity).

10116:Tspan10
gene id: 10116:Tspan10
uniprot id: A6HLC7
names: Subcellular Location Annotation
messages: Membrane

10116:Kifc3
gene id: 10116:Kifc3
uniprot id: A0A8I6ADV7
uniprot id: A1A5P4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

10116:Or51l4
gene id: 10116:Or51l4
uniprot id: A6I7B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:H2ac1
gene id: 10116:H2ac1
uniprot id: A6KLI8
uniprot id: Q00728
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
messages: Deiminated on Arg-4 in granulocytes upon calcium entry.
messages: Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
messages: Nucleus
messages: Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
messages: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
messages: Testis.
messages: The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

10116:Sdcbp2
gene id: 10116:Sdcbp2
uniprot id: Q4KLN0
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Interacts with SDCBP (PubMed:11152476). Interacts with TM4SF1.
messages: Nucleus speckle
messages: The two PDZ domains mediate the interaction with phosphatidylinositol 4,5-bisphosphate (PIP2) and target SDCBP2 to the plasma membranes and nucleoli, PIP2-rich regions.
messages: nucleolus
messages: nucleoplasm

10116:Lipk
gene id: 10116:Lipk
uniprot id: A6I120
uniprot id: D4A9L7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

10116:Ube4a
gene id: 10116:Ube4a
uniprot id: Q6P7A2
uniprot id: Q7TP51
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm
messages: The U-box domain is required for the ubiquitin protein ligase activity.
messages: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.
messages: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.

10116:Ift81
gene id: 10116:Ift81
uniprot id: P83829
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IFT81 family.
messages: Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT74; the interaction is direct: within the IFT complex B, IFT74 and IFT81 mediate the transport of tubulin within the cilium. Interacts with tubulin; the interaction is direct (By similarity). Interacts with IFT57 and IFT70B (By similarity). Interacts with RABL2/RABL2A; binding is equal in the presence of GTP or GDP. Interacts with IFT88 (By similarity). Interacts (via the IFT74/IFT81 heterodimer) with RABL2B (By similarity).
messages: Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling (By similarity). Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella (By similarity).
messages: Cytoplasm
messages: The CH (calponin-homology)-like region shows high similarity to a CH (calponin-homology) domain and mediated binding to the globular domain of tubulin.
messages: cilium

10116:Pheta2
gene id: 10116:Pheta2
uniprot id: A6HT65
uniprot id: D4A374
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

10116:Kdelr1
gene id: 10116:Kdelr1
uniprot id: Q569A6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Phosphorylation by PKA at Ser-209 is required for endoplasmic reticulum retention function.
messages: Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.
messages: Upon ligand binding the receptor oligomerizes and interacts with components of the transport machinery such as ARFGAP1 and ARF1.

10116:Rbm22
gene id: 10116:Rbm22
uniprot id: Q4V7D7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLT11 family.
messages: Component of the pre-catalytic and catalytic spliceosome complexes. Component of the postcatalytic spliceosome P complex. Interacts with PDCD6; the interaction induces translocation of PDCD6 in the cytoplasm. Interacts with PPIL1 (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.
messages: The C-terminal RRM domain and the zinc finger motif are necessary for RNA-binding.

10116:Slco6d1
gene id: 10116:Slco6d1
uniprot id: A0A0G2JWY3
uniprot id: A0A9K3Y706
uniprot id: Q5XI61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Membrane

10116:Htr2a
gene id: 10116:Htr2a
uniprot id: A6HTR4
uniprot id: P14842
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Detected in adult intestine, especially in mucosal epithelium, longitudinal and circular layers of muscularis externa and myenteric plexuses. Highly expressed in Paneth cells, and detected at lower levels in enterocytes (at protein level). Detected in brain cortex.
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin).
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
messages: Interacts (via C-terminus) with MPDZ and PATJ. May interact (via C-terminus) with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2. Interacts with GRM2 and DRD2; this may affect signaling.
messages: Membrane
messages: Presynapse
messages: Synapse
messages: The PDZ domain-binding motif is involved in the interaction with PATJ, CASK, APBA1, DLG1 and DLG4.
messages: Vesicle
messages: axon
messages: caveola
messages: dendrite

10116:Mybph
gene id: 10116:Mybph
uniprot id: O88599
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. MyBP family.
messages: Binds to myosin; probably involved in interaction with thick myofilaments in the A-band.
messages: Skeletal muscle.

10116:Kir3dl1
gene id: 10116:Kir3dl1
uniprot id: P83556
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Receptor on natural killer (NK) cells. Inhibits the activity of NK cells thus preventing cell lysis.

10116:Slc20a2
gene id: 10116:Slc20a2
uniprot id: Q63488
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Cell membrane
messages: Down-regulated by high phosphate diet.
messages: Homodimer.
messages: Kidney (at protein level) (PubMed:20526720, PubMed:19073637). Widely expressed with highest levels in liver, heart and brain (PubMed:8041748).
messages: Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:8041748, PubMed:19073637). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity).

10116:Hrg
gene id: 10116:Hrg
uniprot id: Q99PS8
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in liver, blood plasma, serum and in platelets. Also present in fibrin clots, wound fluid from acute wounds and chronic leg ulcers.
messages: Interacts with THBS1 (via the TSP type I repeats); the interaction blocks the antiangiogenic effect of THBS1 with CD36. Interacts with HPSE; the interaction is enhanced at acidic pH, partially inhibits binding of HPSE to cell surface receptors and modulates its enzymatic activity. Interacts (via the HRR domain) with TMP1; the interaction partially mediates the antiangiogenic properties of HRG. Interacts with kappa and lambda light chains of IgG molecules. Interacts with ATP5F1A; the interaction occurs on the surface of T-cells and alters their cell morphology in concert with CONA. Binds IgG molecules containing kappa and lambda light chains and inhibits the formation of insoluble immunoglobulin complexes. Interacts with F12; the interaction, which is enhanced in the presence of zinc ions and inhibited by heparin-binding to HRG, inhibits factor XII autoactivation and contact-initiated coagulation (By similarity). Interacts with PLG (via its Kringle domains); the interaction tethers PLG to the cell surface and enhances its activation. Interacts (via the HRR domain) with TPM1; the interaction appears to contribute to the antiangiogenic properties of the HRR domain. Interacts with THBS2; the interaction blocks the antiangiogenic effect of THBS2 with CD36 (By similarity).
messages: N-glycosylated.
messages: Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Inhibits rosette formation. Acts as an adapter protein and implicated in regulating many processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2 (By similarity).
messages: Proteolytic cleavage produces several HRG fragments which are mostly disulfide-linked and, therefore, not released. Cleavage by plasmin is inhibited in the presence of heparin, zinc ions or in an acidic environment. Cleavage reduces binding of HRG to heparan sulfate, but enhances the ability of HRG to bind and tether plasminogen to the cell surface. On platelet activation, releases a 33 kDa antiangiogenic peptide which encompasses the HRR. Also cleaved in the C-terminal by plasmin (By similarity).
messages: Secreted
messages: The His-rich (HRR) region contains approximately 12 tandem internal repeats of the 5-residue G[H/P][H/P]PH consensus sequence. HRR binds heparan sulfate and possesses antiangiogenic, antibacterial and antifungal properties through binding Candida cells, and preferentially lysing the ergosterol-containing liposomes at low pH. The tandem repeats also bind divalent metal ions and heme (By similarity).
messages: The cystatin domains can also bind heparan sulfate. Binding is enhanced in the presence of zinc ions (By similarity).

10116:Sgo1
gene id: 10116:Sgo1
uniprot id: D4A624
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

10116:Desi2
gene id: 10116:Desi2
uniprot id: A0A8I6AD20
uniprot id: A0A8I6AF15
uniprot id: Q5XIT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DeSI family.
messages: Cytoplasm
messages: Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization.
messages: Interacts with RPS7.

10116:Pcdhga10
gene id: 10116:Pcdhga10
uniprot id: I6LBW7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

10116:Itga5
gene id: 10116:Itga5
uniprot id: A6KD08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

10116:Adcy4
gene id: 10116:Adcy4
uniprot id: A6KH53
uniprot id: F7EY48
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

10116:Yipf7
gene id: 10116:Yipf7
uniprot id: A6JD92
uniprot id: D3ZHE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

10116:Eci1
gene id: 10116:Eci1
uniprot id: A0A8I6AJI3
uniprot id: Q68G41
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

10116:Mpz
gene id: 10116:Mpz
uniprot id: A6JFU2
uniprot id: P06907
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the myelin P0 protein family.
messages: Cell membrane
messages: Found only in peripheral nervous system Schwann cells.
messages: Homodimer and homotetramer.
messages: Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.
messages: Membrane
messages: N-glycosylated; contains sulfate-substituted glycan.

10116:Ezr
gene id: 10116:Ezr
uniprot id: A6KP14
uniprot id: P31977
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding.
messages: Apical cell membrane
messages: Cell membrane
messages: Cell projection
messages: Glomerular epithelium cell (podocyte). Expressed in cerebrum, cerebellum and hippocampus (at protein level). Expressed in the small intestine, lung, kidney and ovaries.
messages: Has three main structural domains: an N-terminal FERM domain, a central alpha-helical domain and a C-terminal actin-binding domain.
messages: Interacts with PODXL and NHERF2. Found in a complex with EZR, PODXL and NHERF2 (PubMed:11457882). Interacts with PALS1. Interacts with MCC, PLEKHG6, SCYL3/PACE1, NHERF1 and TMEM8B. Interacts (when phosphorylated) with FES/FPS. Interacts with dimeric S100P, the interaction may be activating through unmasking of F-actin binding sites. Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin. Detected in a complex composed of at least EZR, AHNAK, PPL and PRX. Interacts with PDPN (via cytoplasmic domain); activates RHOA and promotes epithelial-mesenchymal transition. Interacts with SPN/CD43 cytoplasmic tail, CD44 and ICAM2 (By similarity). Interacts with SLC9A3; interaction targets SLC9A3 to the apical membrane (By similarity). Interacts with SLC9A1; regulates interactions of SLC9A1 with cytoskeletal and promotes stress fiber formation (PubMed:11163215).
messages: Levels increase in the fetal gut epithelium between day 15 and day 20 of gestation and during the first week after birth.
messages: Membrane
messages: Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity).
messages: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity).
messages: S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.
messages: The FERM domain is organized in a clover-shaped structure that comprises three subdomains identified as F1 (residues 2-82), F2 (residues 96-198), and F3 (residues 204-296). In the active form, the subdomain F3 adopts two mutually exclusive conformational isomers where a row of four phenylalanine side chains (Phe250, Phe255, Phe267 and Phe269) must point in the same direction. In the autoinhibited form, the F3 subdomain interacts with the C-terminal domain (residues 516-586) and stabilizes the structure, selecting only one possible arrangement of phenylalanine side chains. The FERM domain mediates binding to membrane lipids and signaling molecules.
messages: The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
messages: The central alpha-helical domain is composed of two alpha helices (residues 326-406 and 417-466) connected by a linker. It protrudes from the FERM domain forming a coiled coil structure where the linker can have either a loop or a helix conformation. The monomer is predicted to form an intra-molecular helix-loop-helix coiled coil structure. Whereas the dimer adopts an elongated dumbbell-shaped configuration where continuous alpha helices from each protomer are organized in a antiparallel coiled coil structure that connect FERM:C-terminal domain swapped complex at each end. The dimer is predicted to link actin filaments parallel to the plasma membrane.
messages: cell cortex
messages: cytoskeleton
messages: microvillus
messages: microvillus membrane
messages: ruffle membrane

10116:Mns1
gene id: 10116:Mns1
uniprot id: A6KEP4
uniprot id: Q6AXQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Able to form oligomers (By similarity). Interacts with ODAD1 (By similarity).
messages: Belongs to the MNS1 family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis (By similarity). Required for sperm flagella assembly (By similarity). May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules (By similarity).
messages: Nucleus
messages: cilium axoneme
messages: flagellum axoneme

10116:Or4k51
gene id: 10116:Or4k51
uniprot id: A6HP32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Or5b123
gene id: 10116:Or5b123
uniprot id: M0RAH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Nln
gene id: 10116:Nln
uniprot id: A0A0G2JSY3
uniprot id: A6I5E6
uniprot id: P42676
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 1 zinc ion.
messages: Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (PubMed:7836437). Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (PubMed:12500972, PubMed:18077343).
messages: Mitochondrion intermembrane space
messages: cytosol

10116:Luc7l3
gene id: 10116:Luc7l3
uniprot id: A0A8I6AUY1
uniprot id: A6HI41
uniprot id: D3ZFB2
names: Similarity
messages: Belongs to the Luc7 family.

10116:Rgs19
gene id: 10116:Rgs19
uniprot id: O70521
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, predominantly to G(i)-alpha-3. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein (By similarity).
messages: Interacts with GIPC PDZ domain. Interacts with GNAO1.
messages: Membrane
messages: Phosphorylated, mainly on serine residues.

10116:Or12d14c
gene id: 10116:Or12d14c
uniprot id: M0RDZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Lgals9
gene id: 10116:Lgals9
uniprot id: P97840
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds galactosides (By similarity). Has high affinity for the Forssman pentasaccharide (By similarity). Ligand for HAVCR2/TIM3 (By similarity). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (By similarity). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (By similarity). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (By similarity). Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (By similarity). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (By similarity). Inhibits degranulation and induces apoptosis of mast cells (By similarity). Induces maturation and migration of dendritic cells (By similarity). Inhibits natural killer (NK) cell function (By similarity). Can transform NK cell phenotype from peripheral to decidual during pregnancy (By similarity). Astrocyte derived galectin-9 enhances microglial TNF production (PubMed:25158758). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (PubMed:8995305). Highly selective to …
messages: By viral mimic polyinosinic:polycytidylic acid (poly I:C) and lipopolysaccharides (LPS) in microglia.
messages: Contains two homologous but distinct carbohydrate-binding domains.
messages: Cytoplasm
messages: Nucleus
messages: Secreted
messages: The LGALS9-like proteins are encoded by a duplicated regions on chromosome 17; there are at least 3 genes coding for galectin-9-like proteins.
messages: The isoform Long is expressed exclusively in the small intestine.

10116:Actr8
gene id: 10116:Actr8
uniprot id: A6KG53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP8 subfamily.
messages: Chromosome
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

10116:Fam83b
gene id: 10116:Fam83b
uniprot id: A6I1F6
uniprot id: D3ZF70
names: Similarity
messages: Belongs to the FAM83 family.

10116:Perp
gene id: 10116:Perp
uniprot id: B2GVC0
uniprot id: F7FJS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

10116:Smarcd2
gene id: 10116:Smarcd2
uniprot id: A6HK23
uniprot id: O54772
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMARCD family.
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B), and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (ACTB). Interacts with UNKL. Interacts with CEBPE.
messages: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation.
messages: Nucleus
messages: Ubiquitinated through a signaling process involving RAC1 and the RING finger protein UNKL.

10116:Ccl2
gene id: 10116:Ccl2
uniprot id: A6HHD2
uniprot id: P14844
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: In pancreatic islets, secretion is stimulated by IL1B (PubMed:23955712). In islets from Zucker diabetic fatty (ZDF) rats, but not lean animals, secretion is also increased by endocannabinoid anandamide/AEA (PubMed:23955712).
messages: Monomer or homodimer; in equilibrium. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Interacts with TNFAIP6 (via Link domain).
messages: N-Glycosylated.
messages: Processing at the N-terminus can regulate receptor and target cell selectivity (By similarity). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (By similarity).
messages: Secreted

10116:Olr1016
gene id: 10116:Olr1016
uniprot id: A0A8I6AN67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ufsp2
gene id: 10116:Ufsp2
uniprot id: Q5XIB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C78 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Interacts with DDRGK1. Interacts with TRIP4; deufmylates TRIP4.
messages: Nucleus
messages: Thiol-dependent isopeptidase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation.

10116:Hist1h2bq
gene id: 10116:Hist1h2bq
uniprot id: A6KLP6
uniprot id: G3V9C7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

10116:Vps13b
gene id: 10116:Vps13b
uniprot id: A0A8I5Y7Q0
names: Similarity
messages: Belongs to the VPS13 family.

10116:Morf4l1
gene id: 10116:Morf4l1
uniprot id: A0A8I6A2P7
uniprot id: A6I217
uniprot id: A6I218
uniprot id: Q6AYU1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the mSin3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with RB1 and MYST1. May also interact with PHF12 and one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors. Interacts with the N-terminus of MRFAP1. Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts with the entire BRCA complex, which contains BRCA1, PALB2, BRCA2 and RAD51. Interacts with PALB2 (By similarity). Forms a complex with MSL1 and NUPR1 (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci (By similarity).
messages: Nucleus

10116:Atf2
gene id: 10116:Atf2
uniprot id: A6HMA9
uniprot id: Q00969
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Appears to have histone acetyltransferase (HAT) activity, specifically towards histones H2B and H4 in vitro (By similarity). However, it is not clear if this activity is genuine or caused by contamination with other histone acetyltransferases in the assay.
messages: Belongs to the bZIP family.
messages: Belongs to the bZIP family. ATF subfamily.
messages: Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Heterodimerization is essential for its transcriptional activity. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity (By similarity). Interacts with the HK1/VDAC1 complex. Interacts with NBN, MRE11, XPO1, KAT5 and CUL3 (By similarity).
messages: Cytoplasm
messages: Mitochondrion outer membrane
messages: Nucleus
messages: Phosphorylation of Thr-51 by MAPK14 and MAPK11, and at Thr-53 by MAPK1/ERK2, MAPK3/ERK1, MAPK11, MAPK12 and MAPK14 in response to external stimulus like insulin causes increased transcriptional activity. Phosphorylated by PLK3 following hyperosmotic stress. Also phosphorylated and activated by JNK and CaMK4. ATM-mediated phosphorylation at Ser-472 and Ser-480 stimulates its function in DNA damage response. Phosphorylation at Ser-44, Thr-55 and Ser-103 activates its transcriptional activity. Phosphorylation at Thr-51 or Thr-53 enhances acetylation of histones H2B and H4.
messages: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type (By similarity).

10116:Tprkb
gene id: 10116:Tprkb
uniprot id: A6IAU0
uniprot id: G3V805
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

10116:Aspg
gene id: 10116:Aspg
uniprot id: O88202
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (PubMed:9575212, PubMed:8119970, PubMed:10320809). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl-GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3-phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 position of 2-acyl-GPC and 2-acyl-GPE (sn-2 to -1 transfer) (PubMed:10320809). Mediates the synthesis of 1-arachidonoyl species of phospholipids by transferring the arachidonoyl residue from 2-arachidonoyl lysophospholipid to the sn-1 position of 2-acyl lysophospholipid (PubMed:10320809).
messages: Expressed at high levels in liver and kidney and at a low level in stomach. Barely detectable in lung, heart, spleen and brain.
messages: In the N-terminal section; belongs to the asparaginase 1 family.
messages: Inhibited by phosphatidic acid.
messages: Monomer.

10116:Lsm7
gene id: 10116:Lsm7
uniprot id: A6K8E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

10116:MGC94207
gene id: 10116:MGC94207
uniprot id: Q642A4
names: Similarity
messages: Belongs to the UPF0598 family.

10116:Adam26a
gene id: 10116:Adam26a
uniprot id: A0A8I6A576
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Rpl38
gene id: 10116:Rpl38
uniprot id: A6HKI5
uniprot id: P63174
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL38 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

10116:Cpsf6
gene id: 10116:Cpsf6
uniprot id: A0A8I6AMJ9
uniprot id: A6IGS7
uniprot id: A6IGS9
uniprot id: D3ZPL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

10116:Blmh
gene id: 10116:Blmh
uniprot id: A1A5L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

10116:Zfp213
gene id: 10116:Zfp213
uniprot id: A0A8I6ADN5
uniprot id: A6HCJ4
uniprot id: D4A1V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

10116:Adamtsl4
gene id: 10116:Adamtsl4
uniprot id: Q4FZU4
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Although similar to members of the ADAMTS family, it lacks the metalloprotease and disintegrin-like domains which are typical of that family.
messages: Glycosylated (By similarity). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
messages: Interacts with CTSB. Interacts with FBN1 (By similarity).
messages: Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis (By similarity).
messages: extracellular matrix

10116:Pan2
gene id: 10116:Pan2
uniprot id: A6KSB7
uniprot id: Q6IE70
uniprot id: R9PXX6
names: Activity Regulation
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex (By similarity). Interacts with PAN3 isoform 1/Pan3L and isoform 3/Pan3S (By similarity). Interacts with ZFP36 (By similarity).
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts with ZFP36.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: P-body
messages: Positively regulated by the regulatory subunit PAN3.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.

10116:Cog4
gene id: 10116:Cog4
uniprot id: A6IZ72
uniprot id: D3ZZM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG4 family.
messages: Golgi apparatus membrane

10116:Cdca7l
gene id: 10116:Cdca7l
uniprot id: A6KDM3
uniprot id: Q4G059
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with MYC (By similarity). Interacts (via IBM motifs) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (By similarity).
messages: Nucleus
messages: Phosphorylation increases its interaction with PSIP1.
messages: Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 (By similarity).

10116:Wt1
gene id: 10116:Wt1
uniprot id: A6HNW2
uniprot id: D3ZJ55
uniprot id: P49952
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers. Starting from the N-terminus, the second zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine, 5-formylcytosine or 5-carboxylcytosine.
messages: Cytoplasm
messages: Expressed during kidney development.
messages: Interacts with ZNF224 via the zinc-finger region. Interacts with WTAP, AMER1 and SRY. Homodimer. Interacts with WTIP. Interacts with actively translating polysomes. Detected in nuclear ribonucleoprotein (mRNP) particles. Interacts with U2AF2. Interacts with HNRNPU via the zinc-finger region. Interacts with CITED2 (By similarity).
messages: Kidney.
messages: Nucleus
messages: Nucleus speckle
messages: Partially edited.
messages: Presence of the KTS motif hinders interactions between DNA and zinc-finger 4.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
messages: nucleolus
messages: nucleoplasm

10116:Dbi
gene id: 10116:Dbi
uniprot id: P11030
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ACBP family.
messages: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Monomer.

10116:Stab2
gene id: 10116:Stab2
uniprot id: E0X583
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Myh4
gene id: 10116:Myh4
uniprot id: Q29RW1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-4 (MYO4).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: myofibril

10116:Tpd52l3
gene id: 10116:Tpd52l3
uniprot id: A0A0G2QC54
uniprot id: A6I0X7
names: Similarity
messages: Belongs to the TPD52 family.

10116:Sfrp5
gene id: 10116:Sfrp5
uniprot id: A6JHB1
uniprot id: D3ZTV6
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Wdr35
gene id: 10116:Wdr35
uniprot id: A0A8I6ABI7
uniprot id: A6N6J5
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking (By similarity). May promote CASP3 activation and TNF-stimulated apoptosis (PubMed:20193664).
messages: As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.
messages: Component of the IFT complex A (IFT-A) complex. IFT-A complex is divided into a core subcomplex composed of IFT122:IFT140:WDR19 which is associated with TULP3 and a peripheral subcomplex composed of IFT43:WDR35:TTC21B. Interacts directy with IFT122, ITF43 and TTC21B. Interacts with IFT43.
messages: Expressed at high levels in testis and at lower levels in the brain (at protein level). Also present in other tissues, including heart, uterus, spinal cord, ovary, liver, kidney, lung, pancreas and stomach.
messages: centrosome
messages: cilium axoneme
messages: cilium basal body

10116:Trmt10a
gene id: 10116:Trmt10a
uniprot id: Q4KLI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
messages: Interacts with tRNA.
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs.
messages: Ubiquitously expressed. Is more abundant in brain and pancreatic islets compared to other tissues (at protein level).
messages: nucleolus

10116:Sptbn2
gene id: 10116:Sptbn2
uniprot id: A0A8I6A0L7
uniprot id: A6HYY4
names: Similarity
messages: Belongs to the spectrin family.

10116:Mrps16
gene id: 10116:Mrps16
uniprot id: A6KKM7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

10116:Stac3
gene id: 10116:Stac3
uniprot id: A6HQV7
uniprot id: D3ZQN6
names: Subcellular Location Annotation
messages: sarcolemma

10116:Or52j3b
gene id: 10116:Or52j3b
uniprot id: D3ZJT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Olr1327
gene id: 10116:Olr1327
uniprot id: A0A8I5XW99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Pcsk1
gene id: 10116:Pcsk1
uniprot id: A6I4E7
uniprot id: P28840
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Belongs to the peptidase S8 family. Furin subfamily.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

10116:Atg7
gene id: 10116:Atg7
uniprot id: A0A8I6AGV7
uniprot id: A6IKX0
uniprot id: Q641Y5
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated by EP300.
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Facilitates LC3-I lipidation with phosphatidylethanolamine to form LC3-II which is found on autophagosomal membranes (By similarity). Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Also plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation (By similarity). Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity).
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.
messages: Homodimer.
messages: Homodimer. Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. Forms intermediate conjugates with ATG8 family proteins such as GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, or GABARAPL1. Interacts with EP300 acetyltransferase and FOXO1 (By similarity).
messages: Induced in liver hepatocytes by 24 hours of starvation.
messages: Preautophagosomal structure
messages: The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12.
messages: The N-terminal FAP motif (residues 11 to 13) is essential for the formation of the ATG89-PE and ATG5-ATG12 conjugates.
messages: Widely expressed.

10116:Or52n2f
gene id: 10116:Or52n2f
uniprot id: A0A8I5ZS19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Apip
gene id: 10116:Apip
uniprot id: A6HNQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton

10116:Vom2r43
gene id: 10116:Vom2r43
uniprot id: D4AB78
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Gsto2
gene id: 10116:Gsto2
uniprot id: B6DYQ6
uniprot id: Q6AXV9
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

10116:Sec1
gene id: 10116:Sec1
uniprot id: A6JB67
uniprot id: F1MAG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

10116:Sec11a
gene id: 10116:Sec11a
uniprot id: Q6P9X2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:RGD1565367
gene id: 10116:RGD1565367
uniprot id: D2KX48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

10116:RGD1564319
gene id: 10116:RGD1564319
uniprot id: B1H286
names: Similarity
messages: Belongs to the PDCD5 family.

10116:Mlycd
gene id: 10116:Mlycd
uniprot id: Q920F5
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylation at Lys-471 activates malonyl-CoA decarboxylase activity. Deacetylation at Lys-471 by SIRT4 represses activity, leading to promote lipogenesis (By similarity).
messages: Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation.
messages: Cytoplasm
messages: Expressed in liver, heart, skeletal muscles and adipose tissues (at protein level). Ubiquitous. Strongly expressed in liver, kidney, heart, skeletal muscle and adipose tissues. Weakly expressed in brain.
messages: Homotetramer. Dimer of dimers. The two subunits within a dimer display conformational differences suggesting that at any given moment, only one of the two subunits is competent for malonyl-CoA binding and catalytic activity. Under oxidizing conditions, can form disulfide-linked homotetramers (in vitro). Associates with the peroxisomal targeting signal receptor PEX5 (By similarity).
messages: Interchain disulfide bonds may form in peroxisomes (Potential). Interchain disulfide bonds are not expected to form in the reducing environment of the cytoplasm and mitochondria.
messages: Malonyl-CoA decarboxylase activity does not require any cofactors or divalent metal ions.
messages: May be produced by alternative initiation at Met-39 of isoform mitochondrial. Alternatively, represents a proteolytic processed form of the mitochondrial form (PubMed:10947976).
messages: Mitochondrion matrix
messages: Peroxisome
messages: Peroxisome matrix

10116:Ttc9b
gene id: 10116:Ttc9b
uniprot id: A6J9E5
uniprot id: D3ZTK0
names: Similarity
messages: Belongs to the TTC9 family.

10116:Gas2l2
gene id: 10116:Gas2l2
uniprot id: D3ZUE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the GAS2 family.
messages: Cell membrane
messages: Expressed in the cortical tissue (at protein level).
messages: Interacts with ADORA2A (via its cytoplasmic C-terminal domain) (PubMed:23994616). Interacts with GNAS, GNAL, GNAQ, and GNA13 (By similarity). Interacts with MAPRE1 (By similarity).
messages: Involved in the cross-linking of microtubules and microfilaments (By similarity). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (By similarity). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A (By similarity).
messages: cilium basal body
messages: cytoskeleton
messages: stress fiber

10116:Mycbp2
gene id: 10116:Mycbp2
uniprot id: A0A8I6A2N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RING-Cys relay (RCR) family.
messages: axon

10116:Map3k12
gene id: 10116:Map3k12
uniprot id: F1LQ89
uniprot id: Q63796
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated (By similarity).
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts with MBIP (By similarity).
messages: Interacts with MBIP through the leucine-zipper motif.
messages: May be an activator of the JNK/SAPK pathway.
messages: Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway.
messages: The activity of MAP3K12 can be regulated through its proteasomal degradation. APOE, through a receptor-mediated mechanism, activates MAP3K12 by preventing its proteasomal degradation.

10116:Pced1b
gene id: 10116:Pced1b
uniprot id: Q2M1K5
names: Similarity
messages: Belongs to the PC-esterase family.

10116:Rab28
gene id: 10116:Rab28
uniprot id: P51158
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Testis, brain, and to much lower levels heart, skeletal muscle and fat cells. Expressed in the retina.
messages: cilium basal body

10116:Tuba3a
gene id: 10116:Tuba3a
uniprot id: A6ILT9
uniprot id: Q68FR8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.
messages: Belongs to the tubulin family.
messages: Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (By similarity). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle. In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction: detyrosination promotes association with desmin (DES) at force-generating sarcomeres, leading to buckled microtubules and mechanical resistance to contraction (By similarity).
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.
messages: Nitration of Tyr-450 is irreversible and interferes with normal dynein intracellular distribution.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility.
messages: The MREC motif may be critical for tubulin autoregulation.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: Tyrosination promotes microtubule interaction with CAP-Gly domain-containing proteins such as CLIP1, CLIP2 and DCTN1 (By similarity). Tyrosination regulates the initiation of dynein-dynactin motility via interaction with DCTN1, which brings the dynein-dynactin complex into contact with microtubules. In neurons, tyrosinated tubulins mediate the initiation of retrograde vesicle transport (By similarity).
messages: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (MATCAP, VASH1 or VASH2) and tubulin tyrosine ligase (TTL), respectively.
messages: cytoskeleton

10116:Pik3r1
gene id: 10116:Pik3r1
uniprot id: A6I5C5
uniprot id: A6I5C6
uniprot id: M0RC47
uniprot id: Q63787
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the PI3K p85 subunit family.
messages: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).
messages: Heterodimer of a regulatory subunit PIK3R1 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts (via SH2 domains) with CCDC88A/GIV (tyrosine-phosphorylated form); the interaction enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (By similarity). Interacts with phosphorylated LAT, LAX1, TRAT1 and LIME1 upon TCR and/or activation. Interacts with phosphorylated TOM1L1. Interacts with CBLB. The SH2 domains interact with the YTHM motif of phosphorylated INSR in vitro. Also interacts with tyrosine-phosphorylated IGF1R in vitro. Interacts with CD28 and CD3Z upon T-cell activation. Interacts with NISCH, SOCS7 and HCST. Interacts with RUFY3. Interacts with AXL, FASLG, FER, FGR, HCK, KIT and BCR. Interacts with PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated). Interacts with ERBB4 (phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated). Interacts with LYN (via SH3 domain); this enhances enzyme activity. Interacts with NTRK1 (phosphorylated upon ligand-binding). Interacts with PIK3R2; the interaction is dissociated in an insulin-dependent manner. Interacts with XBP1; the interaction is direct and induces translocation of XBP1 into the nucleus in a ER stress- and/or insulin-dependent but PI3K-independent manner (By similarity). Interacts with FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated) (Probable). Interacts with IRS1 and phosphorylated IRS4 (PubMed:8628286). Interacts with PTK2/FAK1 (PubMed:8824286). Interacts with FAM83B; activates the PI3K/AKT signaling cascade (By similarity). Interacts with APPL1 and APPL2 (By similarity). Interacts with SRC (By similarity). Interacts with ALOX5; this interaction bridges ALOX5 with CD40 after CD40 ligation in B cells and leads to the production of reactive oxygen species (ROS) (By similarity). Interacts with TYK2 (By similarity). Interacts with nephrin NPHN1; the int…
messages: In adipose tissue, polyubiquitinated by the BCR(KBTBD2) E3 ubiquitin ligase complex; recognized by KBTBD2 through the SH2 domains, undergoes 'Lys-48'-linked polyubiquitination leading to its degradation.
messages: Phosphorylated. Tyrosine phosphorylated in response to signaling by FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated by CSF1R. Phosphorylated on tyrosine residues by TEK/TIE2. Dephosphorylated by PTPRJ. Phosphorylated by PIK3CA at Ser-608; phosphorylation is stimulated by insulin and PDGF. The relevance of phosphorylation by PIK3CA is however unclear. Phosphorylated in response to KIT and KITLG/SCF. Phosphorylated by FGR and ERBB4 (By similarity).
messages: Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.
messages: The P85-alpha isoform is widely expressed. Expression of the P55-alpha isoform is highest in brain and skeletal muscle. The P50-alpha isoform is abundant in liver with lower levels in brain and muscle.
messages: The SH3 domain mediates the binding to CBLB.

10116:Pgm2
gene id: 10116:Pgm2
uniprot id: A0A8J8XT82
names: Similarity
messages: Belongs to the phosphohexose mutase family.

10116:Hils1
gene id: 10116:Hils1
uniprot id: D3ZZW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.
messages: Nucleus

10116:G6pc1
gene id: 10116:G6pc1
uniprot id: A6HJB1
uniprot id: P43428
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane
messages: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.

10116:Cftr
gene id: 10116:Cftr
uniprot id: A6IE40
uniprot id: P34158
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Binds and hydrolyzes ATP via the two cytoplasmic ABC transporter nucleotide-binding domains. The two ATP-binding domains interact with each other, forming a head-to-tail dimer. Normal ATPase activity requires interaction between the two domains. The first ABC transporter nucleotide-binding domain has no ATPase activity by itself.
messages: Cell membrane
messages: Detected in epithelial cells in nasopharynx, submandibular gland, pancreas and ileum (at protein level) (PubMed:12519745). Expressed in the epididymis (PubMed:30659401). In the caput section of the epididymis, expressed uniformly on both the luminal and basolateral sides of the ducts and on sperm in the caput lumen (at protein level) (PubMed:30659401). In the cauda, detected along the luminal border but not continuously and is also expressed on the basolateral surface (PubMed:30659401). Within the caudal lumen, detected on sperm (PubMed:30659401).
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC4A7 through NHERF1 (By similarity). Interacts with SHANK2 (PubMed:14679199). Interacts with NHERF1 and MYO6. Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity (PubMed:11707463). Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation (By similarity).
messages: N-glycosylated.
messages: Nucleus
messages: Phosphorylated; cAMP treatment promotes phosphorylation and activates the channel. Dephosphorylation decreases the ATPase activity (in vitro). Phosphorylation at PKA sites activates the channel. Phosphorylation at PKC sites enhances the response to phosphorylation by PKA. Phosphorylated by AMPK; this inhibits channel activity.
messages: Recycling endosome membrane
messages: The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, NHERF1/EBP50 complex.
messages: The disordered R region mediates channel activation when it is phosphorylated, but not in the absence of phosphorylation.
messages: Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes enhances its endocytic recycling to the cell membrane. Ubiquitinated by RNF185 during ER stress. Ubiquitinated by MARCHF2 (By similarity).

10116:Mybpc3
gene id: 10116:Mybpc3
uniprot id: P56741
names: Function
names: PTM
names: Similarity
messages: Belongs to the immunoglobulin superfamily. MyBP family.
messages: Polyubiquitinated.
messages: Substrate for phosphorylation by PKA and PKC. Reversible phosphorylation appears to modulate contraction.
messages: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.

10116:Vac14
gene id: 10116:Vac14
uniprot id: A6IZ63
uniprot id: Q80W92
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the VAC14 family.
messages: Endosome membrane
messages: Expressed in brain, lung, kidney and testis with highest levels in brain and testis.
messages: Expressed in embryonic brain.
messages: Forms pentamers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold by pentamerizing into a star-shaped structure, which can bind a single copy each of PIKFYVE and FIG4 and coordinates their activities (By similarity). Interacts with NOS1 (PubMed:17161399).
messages: Microsome membrane
messages: Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
messages: The C-terminal domain (residues 523-782) mediates pentameric interactions and is necessary for the formation and maintenance of the PI(3,5)P2 regulatory complex.

10116:Zfp483
gene id: 10116:Zfp483
uniprot id: A6KDV6
uniprot id: F7EN42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

10116:Hnrnph2
gene id: 10116:Hnrnph2
uniprot id: A6IVG4
uniprot id: Q6AY09
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a ribonucleoprotein complex containing mRNAs and RNA-binding proteins including DDX5, HNRNPH2 and SRSF1 as well as splicing regulator ARVCF. Interacts with TXNL4/DIM1.
messages: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) (By similarity).
messages: nucleoplasm

10116:Osbpl10
gene id: 10116:Osbpl10
uniprot id: F1LWM8
names: Similarity
messages: Belongs to the OSBP family.

10116:Tsr3
gene id: 10116:Tsr3
uniprot id: A6HD11
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Ush2a
gene id: 10116:Ush2a
uniprot id: A0A5H1ZRU3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:C1h11orf58
gene id: 10116:C1h11orf58
uniprot id: A0A8I6AVK1
uniprot id: A6I8D2
names: Similarity
messages: Belongs to the SMAP family.

10116:Prmt7
gene id: 10116:Prmt7
uniprot id: Q5U4E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
messages: Homodimer and heterodimer. Interacts with CTCFL, PRMT5 and SNRPD3 (By similarity).
messages: Nucleus
messages: cytosol

10116:Mmp12
gene id: 10116:Mmp12
uniprot id: A6JN29
uniprot id: Q63341
uniprot id: R9PXT7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 4 Ca(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity).
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: extracellular matrix

10116:Nsun2
gene id: 10116:Nsun2
uniprot id: A6JV18
uniprot id: D4A3S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: extracellular exosome

10116:Tmed9
gene id: 10116:Tmed9
uniprot id: Q5I0E7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 (By similarity).
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Monomer and homodimer in endoplasmic reticulum. Predominantly monomeric and to lesser extent homodimeric in endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Probably oligomerizes with other members of the EMP24/GP25L family such as TMED2, TMED7 and TMED10. Interacts with TMED5. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED9. Interacts with PTPN2 and SPAST (By similarity). Interacts with STX17; the interaction is direct.
messages: N-linked glycosylated containing high mannose.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

10116:Aanat
gene id: 10116:Aanat
uniprot id: Q64666
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the acetyltransferase family. AANAT subfamily.
messages: Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
messages: Cytoplasm
messages: Exhibits night/day variations with an up to 150-fold increased expression at night. Up-regulation is due to a large degree to the release of norepinephrine from nerve terminals in the pineal gland and cAMP signaling pathway. Down-regulated by light-induced proteasomal degradation. In the retina, 10-fold increased expression at night.
messages: Highly expressed at night in pinealocytes and in the retina. Expressed at very low levels in the hindbrain and midbrain.
messages: Monomer (By similarity). Interacts with several 14-3-3 proteins, including YWHAB, YWHAE, YWHAG and YWHAZ, preferentially when phosphorylated at Thr-29 (By similarity). Phosphorylation on Ser-203 also allows binding to YWHAZ, but with lower affinity (By similarity). The interaction with YWHAZ increases affinity for arylalkylamines and acetyl-CoA and protects the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation (By similarity).
messages: cAMP-dependent phosphorylation on both N-terminal Thr-29 and C-terminal Ser-203 regulates AANAT activity by promoting interaction with 14-3-3 proteins.

10116:Or5a1
gene id: 10116:Or5a1
uniprot id: A6I0C6
uniprot id: D3ZSJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Nr3c2
gene id: 10116:Nr3c2
uniprot id: P22199
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Detected in liver, brain, heart, kidney, colon, aorta, hippocampus, hypothalamus and adrenal fasciculata.
messages: Endoplasmic reticulum membrane
messages: Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP4, in the absence of ligand. After ligand binding, it translocates to the nucleus and binds to DNA as a homodimer and as a heterodimer with NR3C1. Binds the coactivator NCOA2. May interact with HSD11B2 in the absence of ligand. Binds the coactivators NCOA1, TIF1 and NRIP1 (By similarity).
messages: Nucleus
messages: Phosphorylated.
messages: Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
messages: Very low transactivation activity, not increased by aldosterone.

10116:Gask1b
gene id: 10116:Gask1b
uniprot id: Q6P7B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GASK family.
messages: Golgi apparatus membrane

10116:Galm
gene id: 10116:Galm
uniprot id: A6H9S6
uniprot id: Q66HG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldose epimerase family.
messages: Cytoplasm
messages: Monomer.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.

10116:Mlnr
gene id: 10116:Mlnr
uniprot id: A6IZR3
uniprot id: F7ER42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

10116:Drc7
gene id: 10116:Drc7
uniprot id: A6JY30
uniprot id: D3ZZ82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC7 family.
messages: cilium axoneme
messages: flagellum
messages: flagellum axoneme

10116:Tsr2
gene id: 10116:Tsr2
uniprot id: A6KL99
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

10116:Hacl1
gene id: 10116:Hacl1
uniprot id: A6KFY4
uniprot id: Q8CHM7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.
messages: Homotetramer.
messages: Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid (PubMed:10468558). Involved also in the shortening of 2-hydroxy long-chain fatty acids (By similarity). Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity).
messages: Peroxisome

10116:Olr1345
gene id: 10116:Olr1345
uniprot id: A6JQU6
uniprot id: D3ZTU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Adcy6
gene id: 10116:Adcy6
uniprot id: A0A0G2K429
uniprot id: A6KC91
uniprot id: A6KC93
uniprot id: Q03343
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by forskolin (PubMed:9391159). Inhibited by calcium ions, already at micromolar concentrations (By similarity). Inhibited by adenosine, AMP and their analogs (By similarity). Activated by GNAS (PubMed:9391159, PubMed:17110384). Is further activated by the complex formed by GNB1 and GNG2 (PubMed:17110384). Phosphorylation by RAF1 results in its activation (PubMed:15385642).
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:1409703, PubMed:15385642, PubMed:17110384, PubMed:21606183). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:21606183). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA (PubMed:21606183). This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (By similarity). Contributes to bone cell responses to mechanical stimuli (By similarity).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Cell membrane
messages: Detected in brain and kidney (PubMed:1409703). Detected in vascular smooth muscle cells (PubMed:21606183).
messages: Membrane
messages: Part of a complex containing AKAP5, ADCY5, PDE4C and PKD2 (By similarity). Interacts with RAF1 (PubMed:15385642). Interacts (via cytoplasmic N-terminus) with GNAS, GNB1 and GNG2 (By similarity).
messages: Phosphorylation by RAF1 increases enzyme activity (PubMed:15385642). Phosphorylation by PKA on Ser-660 inhibits the GNAS-mediated increase in catalytic activity (PubMed:9391159). Phosphorylation by PKC on Ser-554, Ser-660 and Thr-917 inhibits catalytic activity (PubMed:11877398).
messages: The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
messages: cilium
messages: stereocilium

10116:Gapdhs
gene id: 10116:Gapdhs
uniprot id: B1WBQ8
uniprot id: F7FCA4
uniprot id: Q9ESV6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Expressed in both head and flagellum of epididymal sperm.
messages: Homotetramer.
messages: May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity).
messages: The testis-specific N-terminal extension mediates tight association with the cytoskeletal fibrous sheath of the spermatozoa flagellum, possibly via interchain disulfide-bonding of Cys-33 with sheath components.

10116:Ccn3
gene id: 10116:Ccn3
uniprot id: A6HRG0
uniprot id: Q9QZQ5
names: Caution
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CCN family.
messages: Cytoplasm
messages: During persistent inflammatory pain the expression levels are down-regulated.
messages: Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins or membrane receptors such as NOTCH1. Essential regulator of hematopoietic stem and progenitor cell function. Inhibits myogenic differentiation through the activation of Notch-signaling pathway. Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling. Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival. Also plays a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (By similarity). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (By similarity). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:22353423).
messages: Interacts with FBLN1. Interacts (via CTCK domain) with NOTCH1 (via the EGF-like repeat region) (By similarity). Interacts with GJA1/CX43 (PubMed:15181016, PubMed:15213231). Interacts with ITGA5:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity). Interacts with ZDHHC22; the interaction may lead to CCN3 palmitoylation (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be palmitoylated on Cys-238, which is important for extracellular secretion.
messages: Secreted
messages: Widely expressed. Highly expressed in neurons of dorsal root ganglia and dorsal horn of the spinal cord (at protein level) (PubMed:22353423). Expressed in astrocytes (at protein level) (PubMed:15213231). In cartilage, dominantly expressed in the chondrocyte territorial matrix (PubMed:21871891).
messages: gap junction

10116:Sh3rf2
gene id: 10116:Sh3rf2
uniprot id: A6J3J4
uniprot id: Q498M5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated.
messages: Belongs to the SH3RF family.
messages: Has E3 ubiquitin-protein ligase activity. Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation. Inhibits PPP1CA phosphatase activity (By similarity).
messages: Interacts with FASLG and PPP1CA. Interacts with PAK4 and TNFRSF1A (By similarity). Interacts with DLK1, MAP3K10, MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3. Interacts with RAC1 (both active GTP- or inactive GDP-bound forms) (PubMed:22128169).
messages: Nucleus
messages: The RING finger domain is required for ubiquitin ligase activity and autoubiquitination.

10116:Tlr2
gene id: 10116:Tlr2
uniprot id: A0A8K0ZGH5
uniprot id: E9PTD9
uniprot id: Q6YGU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
messages: Membrane

10116:Cd9
gene id: 10116:Cd9
uniprot id: B1WBM0
uniprot id: P40241
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Expressed in the peripheral nervous system.
messages: Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Interacts (via the second extracellular domain) with integrin ITGAV:ITGB3 (By similarity). Interacts with integrin ITGA6:ITGB1; interaction takes place in oocytes and is involved in sperm-egg fusion (By similarity). Part of integrin-tetraspanin complexes composed of CD81, beta-1 and beta-2 integrins in the membrane of monocyte/macrophages (By similarity). Interacts with CD63; identified in a complex with CD63 and ITGB3. Associates with CR2/CD21 and with PTGFRN/CD9P1. Part of a complex composed of CD9, CD81, PTGFRN and IGSF8 (By similarity). Interacts directly with IGSF8. Interacts with PDPN; this interaction is homophilic and attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Interacts (on T cell side) with CD81 at immunological synapses between antigen-presenting cells and T cells (By similarity).
messages: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (By similarity). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (By similarity).
messages: Membrane
messages: Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. Palmitoylation by ZDHHC2 regulates CD9 expression, association with other tetraspanin family proteins and function in cell adhesion.
messages: extracellular exosome

10116:Rab3b
gene id: 10116:Rab3b
uniprot id: A6JYX0
uniprot id: Q63941
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Golgi apparatus
messages: Interacts with RPH3A and RPH3AL (By similarity). Interacts with RIMS1 (PubMed:9252191). Interacts with RIMS2 (PubMed:10748113). The GTP-bound form interacts with GAS8/DRC4 (via coiled-coil domains) (By similarity). Interacts with GDI2, and CHM; phosphorylation at Thr-86 disrupts these interactions (By similarity). Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (By similarity).
messages: Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM and RAB GDP dissociation inhibitor GDI2.
messages: Protein transport. Probably involved in vesicular traffic (By similarity).
messages: Protein transport. Probably involved in vesicular traffic.

10116:Myt1l
gene id: 10116:Myt1l
uniprot id: P70475
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MYT1 family.
messages: Brain, testis and pituitary gland. Expression is higher in the brain than in the testis and pituitary gland. Highest level expression seen in the developing CNS.
messages: Chromosome
messages: Detected at 11.5 dpc and expression is seen throughout the proliferating cortex neuroepithelium, developing medulla, and spinal cord. At 12.5 dpc found in the nasal epithelium and at 13.5 dpc detected in the trigeminal ganglia, dorsal root ganglia and the ganglion cell layer of the retina. At 14 dpc to 15 dpc, expressed at high levels in the brain and spinal cord and then levels subsequently decrease.
messages: Interacts with SIN3B.
messages: Nucleus
messages: Transcription factor that plays a key role in neuronal differentiation (PubMed:9373037). Acts by specifically repressing expression of non-neuronal genes during neuron differentiation (By similarity). In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs (By similarity). Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1 (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B (By similarity). The 5'-AAGTT-3' core motif is absent from the promoter of neural genes (By similarity).

10116:Cpsf3
gene id: 10116:Cpsf3
uniprot id: Q499P4
names: Subcellular Location Annotation
messages: Nucleus

10116:Tceanc2
gene id: 10116:Tceanc2
uniprot id: A6JYQ7
uniprot id: Q5XIC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCEANC2 family.
messages: Nucleus

10116:Cdc14b
gene id: 10116:Cdc14b
uniprot id: A6KQD8
uniprot id: F1M567
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

10116:Eif4enif1
gene id: 10116:Eif4enif1
uniprot id: A0A8I6A9M0
uniprot id: A6IK92
uniprot id: D4ACF1
names: Subcellular Location Annotation
messages: Cytoplasm

10116:Tlr10
gene id: 10116:Tlr10
uniprot id: A0A8I6AFM9
uniprot id: C0LSK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

10116:Puf60
gene id: 10116:Puf60
uniprot id: A6HS56
uniprot id: A6HS57
uniprot id: Q9WV25
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM half pint family.
messages: DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA (By similarity).
messages: Homodimer (By similarity). Associates with the spliceosome (By similarity). Found in a complex with RO60 and Y5 RNA (By similarity). Found in a complex with FUBP1 and far upstream element (FUSE) DNA segment (By similarity). Interacts directly with ERCC3 (By similarity). Interacts with CDK7 and GTF2H1 (By similarity). Interacts with SRSF11/P54 (By similarity).
messages: Nucleus
messages: The third RNA recognition motif, called PUMP domain, is atypical and may rather mediate homodimerization and/or protein-protein interactions.

10116:Prm1
gene id: 10116:Prm1
uniprot id: A6K4I5
uniprot id: P10118
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protamine P1 family.
messages: Chromosome
messages: Cross-linked by interchain disulfide bonds around the DNA-helix.
messages: Nucleus
messages: Phosphorylated by SRPK1.
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
messages: Testis.

10116:Hspa13
gene id: 10116:Hspa13
uniprot id: A6JL16
uniprot id: O35162
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds UBQLN2.
messages: Endoplasmic reticulum
messages: Has peptide-independent ATPase activity.
messages: Microsome

10116:Tmem9
gene id: 10116:Tmem9
uniprot id: A0A0G2JUD1
uniprot id: A6ICH5
names: Similarity
messages: Belongs to the TMEM9 family.

10116:Comp
gene id: 10116:Comp
uniprot id: P35444
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thrombospondin family.
messages: Binds 11-14 calcium ions per subunit.
messages: Each of the eight TSP type-3 repeats binds two calcium ions. The TSP C-terminal domain binds three calcium ions.
messages: Pentamer; disulfide-linked. Exists in a more compact conformation in the presence of calcium and shows a more extended conformation in the absence of calcium. Interacts with ITGB3, ITGA5 and FN1. Binding to FN1 requires the presence of divalent cations (Ca(2+), Mg(2+) or Mn(2+)). The greatest amount of binding is seen in the presence of Mn(2+). Interacts with MATN1, MATN3, MATN4 and ACAN. Binds heparin, heparan sulfate and chondroitin sulfate. EDTA dimishes significantly its binding to ACAN and abolishes its binding to MATN3, MATN4 and chondroitin sulfate. Interacts with collagen I, II and IX, and interaction with these collagens is dependent on the presence of zinc ions. Interacts with ADAMTS12 (By similarity). Interacts with ITGA7 (PubMed:20019333).
messages: Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (By similarity). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (PubMed:20019333).
messages: The TSP C-terminal domain mediates interaction with FN1 and ACAN.
messages: The cell attachment motif mediates the attachment to chondrocytes. It mediates the induction of both the IAP family of survival proteins and the antiapoptotic response.
messages: extracellular matrix

10116:Rtbdn
gene id: 10116:Rtbdn
uniprot id: A6IY57
uniprot id: D3ZWD2
names: Similarity
messages: Belongs to the folate receptor family.

10116:Or5w11
gene id: 10116:Or5w11
uniprot id: A6HMZ7
uniprot id: D3ZRJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Kif3a
gene id: 10116:Kif3a
uniprot id: A6HED3
uniprot id: F1LQZ3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

10116:LOC500028
gene id: 10116:LOC500028
uniprot id: Q6TXH1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

10116:LOC102552474
gene id: 10116:LOC102552474
uniprot id: A6KU56
uniprot id: D4ADV7
names: Similarity
messages: Belongs to the FAM47 family.

10116:Snupn
gene id: 10116:Snupn
uniprot id: A6J4S2
uniprot id: Q68FP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snurportin family.
messages: Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts (via IBB domain) with KPNB1; the interaction is direct. Interacts with DDX20, IPO7, SMN1, SNRPB and XPO1. Interacts directly with XPO1. Its interaction with XPO1 and binding to m3G-cap U snRNPs appears to be mutually exclusive.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

10116:Tmem168
gene id: 10116:Tmem168
uniprot id: A6IDZ9
uniprot id: Q5PQM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane
messages: Nucleus membrane
messages: Plays a key role in maintaining the cardiac electrical stability by modulating cell surface expression of SCN5A. May play a role i the modulation of anxiety behavior by regulating GABAergic neuronal system in the nucleus accumbens.

10116:Mmd2
gene id: 10116:Mmd2
uniprot id: B1WBN0
uniprot id: F7F9F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

10116:Calm2
gene id: 10116:Calm2
uniprot id: P0DP29
uniprot id: P0DP30
uniprot id: P0DP31
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calmodulin family.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Is a regulator of voltage-dependent L-type calcium channels. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding. Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2.
messages: Interacts with CEP97, CCP110, TTN/titin and SRY (By similarity). Interacts with MYO5A and RRAD (PubMed:18056528). Interacts with USP6; the interaction is calcium dependent (By similarity). Interacts with CDK5RAP2 (By similarity). Interacts with SCN5A (By similarity). Interacts with RYR1 (By similarity). Interacts with FCHO1 (By similarity). Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure (By similarity). Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (By similarity). Interacts with SYT7 (By similarity). Interacts with MYO10 and MYO1C (By similarity). Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (PubMed:8576129). Interacts with RYR2; regulates RYR2 calcium-release channel activity (By similarity). Interacts with PCP4; regulates calmodulin calcium-binding (By similarity). Interacts with the heterotetrameric KCNQ2 and KCNQ3 channel; the interaction is calcium-independent, constitutive and participates in the proper assembly of a functional heterotetrameric M channel (By similarity).
messages: Interacts with CEP97, CCP110, TTN/titin and SRY (By similarity). Interacts with MYO5A and RRAD (PubMed:18056528). Interacts with USP6; the interaction is calcium dependent (By similarity). Interacts with CDK5RAP2 (By similarity). Interacts with SCN5A (By similarity). Interacts with RYR1 (By similarity). Interacts with FCHO1 (By similarity). Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure (By similarity). Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (PubMed:23109337). Interacts with SYT7 (By similarity). Interacts with MYO10 and MYO1C (By similarity). Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (PubMed:8576129). Interacts with RYR2; regulates RYR2 calcium-release channel activity (By similarity). Interacts with PCP4; regulates calmodulin calcium-binding (By similarity). Interacts with the heterotetrameric KCNQ2 and KCNQ3 channel; the interaction is calcium-independent, constitutive and participates in the proper assembly of a functional heterotetrameric M channel (By similarity). Interacts with SLC9A1 in a calcium-dependent manner (By similarity). In the absence of Ca(+2), interacts with GIMAP4 (via IQ domain) (By similarity). Interacts with SCN8A; the interaction modulates the inactivation rate of SCN8A (By similarity). Interaction with KIF1A; the interaction is increased in presence of calcium and increases neuronal dense core vesicles motility (PubMed:30021165). Interacts with KCNN3 (By similarity). Interacts with KCNQ1 (via C-terminus); forms a heterooctameric structure (with 4:4 KCNQ1:CALM stoichiometry) in a calcium-independent manner (By similarity). Interacts with PIK3C3; the interaction modulates PIK3C3 kinase activity (By similarity). Interacts with HINT1; interaction increases in the presen…
messages: Phosphorylation results in a decreased activity.
messages: The N-terminal and C-terminal lobes of CALM bind to the C-terminus of KCNQ1 in a clamp-like conformation. Binding of CALM C-terminus to KCNQ1 is calcium-independent but is essential for assembly of the structure. Binding of CALM N-terminus to KCNQ1 is calcium-dependent and regulates electrophysiological activity of the channel.
messages: This protein has four functional calcium-binding sites.
messages: Ubiquitination results in a strongly decreased activity.
messages: centrosome
messages: flagellum
messages: spindle
messages: spindle pole

10116:Hexa
gene id: 10116:Hexa
uniprot id: A6J526
uniprot id: Q641X3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Addition of GM2A stimulates the hydrolysis of sulfated glycosphingolipid SM2 and the ganglioside GM2.
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A.
messages: Lysosome
messages: There are 3 beta-hexosaminidase isozymes: isozyme A (hexosaminidase A) is an heterodimer composed of one subunit alpha and one subunit beta (chain A and B); isozyme B (hexosaminidase B) is an homodimer of two beta subunits (two chains A and B); isozyme S (hexosaminidase S) is a homodimer of two alpha subunits. The composition of the dimer (isozyme A versus isozyme S) has a significant effect on the substrate specificity of the alpha subunit active site.

10116:Hnrnpm
gene id: 10116:Hnrnpm
uniprot id: Q62826
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in all tissues tested, including liver, heart, lung, skeletal muscle, kidney, stomach, large intestine, small intestine, pancreas, spleen, peritoneal macrophage and thyroid.
messages: Identified in the spliceosome C complex (By similarity). Interacts with PPIA/CYPA (By similarity).
messages: Nucleus matrix
messages: Pre-mRNA binding protein, binds avidly to poly(G) and poly(U) RNA homopolymers. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
messages: Sumoylated.

10116:Dll4
gene id: 10116:Dll4
uniprot id: A6HPF0
uniprot id: D3ZHH1
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NOTCH4 (By similarity). Interacts (via N-terminal DSL and MNNL domains) with NOTCH1 (via EGF-like domains) (PubMed:25700513).
messages: Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4 (PubMed:25700513). Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

10116:Garin1b
gene id: 10116:Garin1b
uniprot id: Q68FV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GARIN family.
messages: Golgi apparatus
messages: RAB2B effector protein required for accurate acrosome formation and normal male fertility. In complex with RAB2A/RAB2B, seems to suppress excessive vesicle trafficking during acrosome formation.

10116:Tnni3
gene id: 10116:Tnni3
uniprot id: P23693
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the troponin I family.
messages: Interacts with TRIM63 (By similarity). Binds to actin and tropomyosin. Interacts with STK4/MST1 (By similarity).
messages: Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-32. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylated at Ser-43 and Ser-45 by PRKCE; phosphorylation increases myocardium contractile dysfunction (By similarity).
messages: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

10116:Uhrf1
gene id: 10116:Uhrf1
uniprot id: A0A0G2JT07
uniprot id: A0A0G2JXJ2
uniprot id: Q7TPK1
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with DNMT3A and DNMT3B. Interacts with DNMT1; the interaction is direct. Interacts with USP7; leading to its deubiquitination. Interacts with histone H3. Interacts with HDAC1, but not with HDAC2. Interacts with BLTP3A. Interacts with PML. Interacts with EHMT2. Binds methylated CpG containing oligonucleotides (By similarity). Interacts with ZNF263; recruited to the SIX3 promoter along with other proteins involved in chromatin modification and transcriptional corepression where it contributes to transcriptional repression (By similarity). Interacts with UHRF2 (By similarity). Interacts with FANCD2 (By similarity). Interacts with TET1 isoform 2; this interaction induces the recruitment of TET1 isoform 2 to replicating heterochromatin (By similarity).
messages: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.
messages: Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF1 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation (By similarity).
messages: Nucleus
messages: Phosphorylation at Ser-295 of the linker region decreases the binding to H3K9me3. Phosphorylation at Ser-631 by CDK1 during M phase impairs interaction with USP7, preventing deubiquitination and leading to degradation by the proteasome (By similarity).
messages: The RING finger is required for ubiquitin ligase activity.
messages: The YDG domain (also named SRA domain) specifically recognizes and binds hemimethylated DNA at replication forks (DNA that is only methylated on the mother strand of replicating DNA). It contains a binding pocket that accommodates the 5-methylcytosine that is flipped out of the duplex DNA. 2 specialized loops reach through the resulting gap in the DNA from both the major and the minor grooves to read the other 3 bases of the CpG duplex. The major groove loop confers both specificity for the CpG dinucleotide and discrimination against methylation of deoxycytidine of the complementary strand. The YDG domain also recognizes and binds 5-hydroxymethylcytosine (5hmC) (By similarity).
messages: The YDG domain mediates the interaction with histone H3.
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3). The tudor-like regions simultaneously recognizes H3K9me3 through a conserved aromatic cage in the first tudor-like subdomain and unmodified H3K4 (H3K4me0) within a groove between the tandem subdomains. The linker region plays a role in the formation of a histone H3-binding hole between the reader modules formed by the tudor-like regions and the PHD-type zinc finger by making extended contacts with the tandem tudor-like regions (By similarity).
messages: Ubiquitinated; which leads to proteasomal degradation. Autoubiquitinated; interaction with USP7 leads to deubiquitination and prevents degradation. Ubiquitination and degradation takes place during M phase, when phosphorylation at Ser-631 prevents interaction with USP7 and subsequent deubiquitination. Polyubiquitination may be stimulated by DNA damage (By similarity).

10116:Gorasp2
gene id: 10116:Gorasp2
uniprot id: A0A8I6A616
uniprot id: Q68G33
names: Similarity
messages: Belongs to the GORASP family.

10116:B3gat2
gene id: 10116:B3gat2
uniprot id: A6JJA7
uniprot id: Q9Z137
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 43 family.
messages: Expressed in the cerebral cortex, cerebellum and whole brain.
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Substrates include asialo-orosomucoid (ASOR), paragloboside (lacto-N-neotetraosylceramide), Gal-beta-1,4-GlcNAc-beta-1,3-Gal-beta-1,4-Glc-pyridylamine and Gal-beta-1,3-GlcNAc-beta-1,3-Gal-beta-1,4-Glc-pyridylamine.
messages: Membrane

10116:Olr1314
gene id: 10116:Olr1314
uniprot id: A6J3N0
uniprot id: D4A7M9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Garin1a
gene id: 10116:Garin1a
uniprot id: Q5RJN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GARIN family.
messages: Golgi apparatus
messages: Interacts (via N-terminus) with RAB2B (in GTP-bound form).
messages: RAB2B effector protein required for accurate acrosome formation and normal male fertility.

10116:C2h4orf33
gene id: 10116:C2h4orf33
uniprot id: Q5M845
names: Similarity
messages: Belongs to the UPF0462 family.

10116:Rab39a
gene id: 10116:Rab39a
uniprot id: A6J4J9
uniprot id: D3ZZP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

10116:Josd1
gene id: 10116:Josd1
uniprot id: Q5BJY4
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity).
messages: Interacts with beta-actin/ACTB.
messages: Monoubiquitinated. Ubiquitination activates deubiquitination activity in vitro.

10116:Arpc2
gene id: 10116:Arpc2
uniprot id: A0A0H2UHL5
uniprot id: A6JVT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton
messages: synaptosome

10116:Slc4a11
gene id: 10116:Slc4a11
uniprot id: A6HQA9
uniprot id: D3ZVP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

10116:Mmp10
gene id: 10116:Mmp10
uniprot id: P07152
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: extracellular matrix

10116:Mlxipl
gene id: 10116:Mlxipl
uniprot id: Q8VIP2
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds DNA as a heterodimer with TCFL4/MLX.
messages: Nucleus
messages: Phosphorylation at Ser-568 by AMPK inactivates the DNA-binding activity.
messages: Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity).

10116:Kcnh7
gene id: 10116:Kcnh7
uniprot id: A6HLW2
uniprot id: O54852
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.3/KCNH7 sub-subfamily.
messages: Detected in total brain, in superior cervical, mesenteric and celiac ganglia, and at very low levels in retina. Found in pituitary.
messages: Membrane
messages: Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH6/ERG2.
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

10116:Pitpnm1
gene id: 10116:Pitpnm1
uniprot id: A6HYT2
uniprot id: Q5U2N3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.
messages: Catalyzes the transfer of phosphatidylinositol (PI) between membranes (By similarity). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (By similarity). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (By similarity). Necessary for normal completion of cytokinesis (By similarity). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (By similarity). Required for protein export from the endoplasmic reticulum and the Golgi (By similarity). Binds calcium ions (By similarity).
messages: Cleavage furrow
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi stack membrane
messages: Interacts with PIK4CA and VAPB. Interacts with PTK2B via its C-terminus. Interacts with RHOA. Has higher affinity for the inactive, GDP-bound form of RHOA. The CDK1-phosphorylated form interacts with PLK1 (By similarity).
messages: Lipid droplet
messages: Midbody
messages: Phosphorylated on multiple sites by CDK1 at the onset of mitosis. Phosphorylation facilitates dissociation from the Golgi complex and is required for interaction with PLK1 (By similarity).
messages: Phosphorylated on threonine residues upon treatment with oleic acid.
messages: Phosphorylated on tyrosine residues by PTK2B.

10116:Slc15a5
gene id: 10116:Slc15a5
uniprot id: D3ZKX5
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

10116:Kif26a
gene id: 10116:Kif26a
uniprot id: A0A0G2JWJ1
uniprot id: D3ZUT0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

10116:H2az1
gene id: 10116:H2az1
uniprot id: A6HW07
uniprot id: P0C0S7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-5, Lys-8, Lys-12 and Lys-14 by KAT2A; KAT2A is recruited by the XPC complex in absence of DNA damage (By similarity). Acetylated on Lys-5, Lys-8 and Lys-12 during interphase; acetylation disappears at mitosis (By similarity). Acetylation by the NuA4 histone acetyltransferase complex is required for hematopoietic stem cell maintenance (By similarity).
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated on Lys-5 and Lys-8 by SETD6. SETD6 predominantly methylates Lys-8, lys-5 being a possible secondary site.
messages: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
messages: Not phosphorylated.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AZ1 forms a heterodimer with H2B. H2AZ1 interacts with INCENP. Interacts (via M6 cassette) with ANP32E; leading to removal of H2A.Z/H2AZ1 from the nucleosome. Interacts with VPS72 (via N-terminal domain); the interaction is enhanced by VPS72 phosphorylation which is promoted by ZNHIT1. Interacts with PWWP2A. Interacts with FH (when phosphorylated by PRKDC). Interacts with ZNHIT1; the interaction results in recruitment of H2AZ1 to the MYOG promoter region which is required for muscle-specific gene expression (By similarity).
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity).

10116:Casp9
gene id: 10116:Casp9
uniprot id: A0A9K3Y7W8
uniprot id: Q9JHK1
names: Similarity
messages: Belongs to the peptidase C14A family.

10116:Olr1142
gene id: 10116:Olr1142
uniprot id: A0A8I6AMG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Hsd17b11
gene id: 10116:Hsd17b11
uniprot id: Q6AYS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
messages: Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione.
messages: Endoplasmic reticulum
messages: Lipid droplet

10116:Wdr46
gene id: 10116:Wdr46
uniprot id: Q5U2N9
uniprot id: Q6MGC3
names: Subcellular Location Annotation
messages: nucleolus

10116:Clps
gene id: 10116:Clps
uniprot id: P17084
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the colipase family.
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Expressed by the pancreas.
messages: Expression levels increase upon lipid ingestion.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Readily detectable during gestation, reaches adult levels by 17-20 days gestation, rises markedly at 7 days of age but falls to adult levels by 14 days and remains at that level throughout the suckling-weanling period.
messages: Secreted

10116:Nherf2
gene id: 10116:Nherf2
uniprot id: A6HCU6
uniprot id: A6HCU7
uniprot id: G3V6D9
uniprot id: Q920G2
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Cell membrane
messages: Endomembrane system
messages: Glomerular epithelium cell (podocyte) (at protein level). Detected in liver, bile duct, kidney glomerulus and lung.
messages: Homodimer, and heterodimer with NHERF1. Binds ADRB2, SLC9A3, P2RY1, P2YR2, SRY, RDX, PDZK1 and LPAR2 (By similarity). Found in a complex with EZR, PODXL and NHERF2. Interacts (via the PDZ domains) with PODXL (via the C-terminal PDZ-binding motif DTHL); interaction is detected in glomerular epithelium cells. Interacts with SGK1 and KCNJ1/ROMK1 (By similarity). Interacts (via the PDZ domains) with SLC26A6 (By similarity).
messages: Nucleus
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus.

10116:Hnrnpa1
gene id: 10116:Hnrnpa1
uniprot id: A0A8I6ALC1
uniprot id: A6KD00
uniprot id: P04256
uniprot id: Q5I0M7
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SEPT6. Interacts with C9orf72. Interacts with KHDRBS1. Interacts with UBQLN2 (By similarity). Interacts with PPIA/CYPA (By similarity).
messages: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. May bind to specific miRNA hairpins.
messages: Nucleus
messages: Sumoylated.

10116:Krtap16-5
gene id: 10116:Krtap16-5
uniprot id: A6JLA8
uniprot id: D3ZK72
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

10116:Slc38a5
gene id: 10116:Slc38a5
uniprot id: A2VCW5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Cell membrane
messages: Highly expressed in neocortex, hippocampus, striatum and spinal cord by astrocytes (at protein level) (PubMed:15390093). Expressed in brain, lung, stomach, kidney, spleen and testis (PubMed:11698233). Expressed in the cerebral cortex between the second and third postnatal week, where expressed exclusively in glial cells from postnatal day 14 to adulthood (at protein level) (PubMed:24333324). Expressed in the cerebellum at post natal day 12 (P12) (PubMed:24333324). Expressed in liver (PubMed:15218073, PubMed:11698233). Expressed inside the cell body of the astrocytes (PubMed:22821889).
messages: Nakanishi et al (PubMed:11698233) shows that the transport process is electrogenic, contrary to the conclusions of Hamdani et al (PubMed:22821889) who finds that the transport is electroneutral with a Na(+):L-glutamine stoichiometry of 1:1 (PubMed:22821889, PubMed:11698233). Hamdani et al. shows that this electrogenic transport describes by Nakanishi et al. would correspond to large uncoupled fluxes of protons (PubMed:22821889, PubMed:11698233).
messages: Not inhibited by lithium (By similarity). Partial allosteric regulation on ions sodium binding (PubMed:16629640).
messages: Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:11698233, PubMed:16629640, PubMed:15218073, PubMed:22821889, PubMed:16249471). Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-glutamine cycle and the NMDA receptors activation (PubMed:22821889). In addition contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells and, therefore participates in the retinal glutamate-glutamine cycle (PubMed:16249471). The transport activity is pH sensitive (PubMed:22821889, PubMed:15218073, PubMed:11698233), Li(+) tolerant (PubMed:22821889, PubMed:15218073, PubMed:11698233), bidirectional (PubMed:22821889, PubMed:15218073) and associated with large uncoupled fluxes of protons (PubMed:22821889, PubMed:15218073, PubMed:11698233). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (PubMed:22821889). May have particular importance for modulation of net hepatic glutamine flux (PubMed:15218073).

10116:Zfpm2
gene id: 10116:Zfpm2
uniprot id: A6HR90
uniprot id: D4A0R1
names: Subcellular Location Annotation
messages: Nucleus

10116:Ggt6
gene id: 10116:Ggt6
uniprot id: Q6IE08
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaved by autocatalysis into a large and a small subunit and the autocatalytic cleavage is essential to the functional activation of the enzyme.
messages: Heterodimer composed of the light and heavy chains. The active site is located in the light chain.
messages: Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors.
messages: Membrane

10116:Or2t6
gene id: 10116:Or2t6
uniprot id: A6K068
uniprot id: D3ZDH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ggn
gene id: 10116:Ggn
uniprot id: Q66HC8
names: Function
names: Subunit
messages: Interacts with FANCL, GGNBP1 and ZNF403/GGNBP2.
messages: May be involved in spermatogenesis.

10116:Hrh3
gene id: 10116:Hrh3
uniprot id: A6KMB7
uniprot id: Q2VJ17
uniprot id: Q2VJ18
uniprot id: Q541U0
uniprot id: Q5PPG3
uniprot id: Q9QYN8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed abundantly in brain, most notably throughout the thalamus, the ventromedial hypothalamus and the caudate nucleus. Isoform 1 is largely predominant in all tissues.
messages: Membrane
messages: Proxyfan acts as a potent neutral antagonist while thioperamide, ciproxifan and FUB465 act as potent inverse agonists.
messages: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist).

10116:Sumf1
gene id: 10116:Sumf1
uniprot id: A6IBK9
uniprot id: D4A7I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

10116:Entpd4
gene id: 10116:Entpd4
uniprot id: A6HTH4
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

10116:Defb15
gene id: 10116:Defb15
uniprot id: A0A0G2JSX4
uniprot id: A6IWA7
uniprot id: Q32ZH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

10116:Scfd2
gene id: 10116:Scfd2
uniprot id: Q5U2R9
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

10116:Gabrp
gene id: 10116:Gabrp
uniprot id: O09028
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRP sub-subfamily.
messages: Cell membrane
messages: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and epsilon. A sixth class of subunit: Rho form homomeric GABA receptors that do not appear to coexist with GABA(A) receptor subunits but with GABA(C) receptor subunits. Subunit Pi can also bind this complex.
messages: Postsynaptic cell membrane

10116:Smad3
gene id: 10116:Smad3
uniprot id: A6J5A4
uniprot id: P84025
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylation in the nucleus by EP300 in the MH2 domain regulates positively its transcriptional activity and is enhanced by TGF-beta.
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Expressed in the brain (PubMed:8917532). Expressed in cardiomyocytes (PubMed:21791611).
messages: Monomer; in the absence of TGF-beta (By similarity). Homooligomer; in the presence of TGF-beta (By similarity). Heterotrimer; forms a heterotrimer in the presence of TGF-beta consisting of two molecules of C-terminally phosphorylated SMAD2 or SMAD3 and one of SMAD4 to form the transcriptionally active SMAD2/SMAD3-SMAD4 complex (By similarity). Part of a complex consisting of MAGI2/ARIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). Forms a complex with SMAD2 and TRIM33 upon addition of TGF-beta (By similarity). Found in a complex composed of SMAD3, RAN and XPO4; within the complex interacts directly with XPO4 (By similarity). Component of the multimeric complex SMAD3/SMAD4/JUN/FOS which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta (By similarity). Part of a ternary complex composed of SMAD3, ITCH/AIP4 and NEDD9/HEF1; within the complex NEDD9/HEF1 interacts (via N-terminus) with ITCH/AIP4; the complex mediates ubiquitination and proteasomal degradation of NEDD9/HEF1 (By similarity). Interacts with NEDD9; the interaction promotes NEDD9 ubiquitination and proteasomal degradation (By similarity). Interacts (via an N-terminal domain) with JUN (via its basic DNA binding and leucine zipper domains); this interaction is essential for DNA binding and cooperative transcriptional activity in response to TGF-beta (By similarity). Identified in a complex that contains at least ZNF451, SMAD2, SMAD3 and SMAD4 (By similarity). Interacts with PPM1A; the interaction dephosphorylates SMAD3 in the C-terminal SXS motif leading to disruption of the SMAD2/3-SMAD4 complex, nuclear export and termination of TGF-beta signaling (By similarity). Interacts (via MH2 domain) with ZMIZ1 (via SP-RING-type domain); in the TGF-beta signaling pathway increases the activity of the SMAD3/SMAD4 transcriptional complex (By similarity). Interacts (when phosphorylated) with RNF111; RNF111 acts as an enhancer of the transcriptional responses by mediat…
messages: Nucleus
messages: Phosphorylated on serine and threonine residues. Enhanced phosphorylation in the linker region on Thr-179, Ser-204 and Ser-208 on EGF and TGF-beta treatment. Ser-208 is the main site of MAPK-mediated phosphorylation. CDK-mediated phosphorylation occurs in a cell-cycle dependent manner and inhibits both the transcriptional activity and antiproliferative functions of SMAD3. This phosphorylation is inhibited by flavopiridol. Maximum phosphorylation at the G(1)/S junction. Also phosphorylated on serine residues in the C-terminal SXS motif by TGFBR1 and ACVR1. TGFBR1-mediated phosphorylation at these C-terminal sites is required for interaction with SMAD4, nuclear location and transactivational activity, and appears to be a prerequisite for the TGF-beta mediated phosphorylation in the linker region. Dephosphorylated in the C-terminal SXS motif by PPM1A. This dephosphorylation disrupts the interaction with SMAD4, promotes nuclear export and terminates TGF-beta-mediated signaling. Phosphorylation at Ser-418 by CSNK1G2/CK1 promotes ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Phosphorylated by PDPK1 (By similarity).
messages: Poly-ADP-ribosylated by PARP1 and PARP2. ADP-ribosylation negatively regulates SMAD3 transcriptional responses during the course of TGF-beta signaling.
messages: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).
messages: The MH1 domain is required for DNA binding (By similarity). Also binds zinc ions which are necessary for the DNA binding.
messages: The MH2 domain is required for both homomeric and heteromeric interactions and for transcriptional regulation. Sufficient for nuclear import (By similarity).
messages: The linker region is required for the TGFbeta-mediated transcriptional activity and acts synergistically with the MH2 domain.
messages: Ubiquitinated. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes. Ubiquitinated by RNF111, leading to its degradation: only SMAD3 proteins, that are 'in use' are targeted by RNF111, RNF111 playing a key role in activating SMAD3 and regulating its turnover. Undergoes STUB1-mediated ubiquitination and degradation.

10116:Chsy1
gene id: 10116:Chsy1
uniprot id: A6JBQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

10116:Eral1
gene id: 10116:Eral1
uniprot id: Q5EBA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity).

10116:Golt1a
gene id: 10116:Golt1a
uniprot id: A6IC72
uniprot id: D3ZFB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

10116:Mocs3
gene id: 10116:Mocs3
uniprot id: A6JXP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Interacts with NFS1.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

10116:Ccl28
gene id: 10116:Ccl28
uniprot id: Q91Y39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

10116:Prokr1
gene id: 10116:Prokr1
uniprot id: A6IB09
uniprot id: Q8R416
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy (By similarity).
messages: Widely expressed in peripheral tissues with the highest level in the spleen and moderate levels in the adipose tissues, thymus, lung, kidney, testis, uterus and small intestine.

10116:Map3k8
gene id: 10116:Map3k8
uniprot id: G3V840
uniprot id: Q63562
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm
messages: Expressed in spleen, thymus, liver and lung.
messages: Forms a ternary complex with NFKB1/p105 and TNIP2. Interacts with NFKB1; the interaction increases the stability of MAP3K8 but inhibits its MEK phosphorylation activity, whereas loss of interaction following LPS stimulation leads to its degradation. Interacts with CD40 and TRAF6; the interaction is required for ERK activation. Interacts with KSR2; the interaction inhibits ERK and NF-kappa-B activation.
messages: Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle.

10116:Mfge8
gene id: 10116:Mfge8
uniprot id: A6JC45
uniprot id: P70490
uniprot id: Q1PBJ1
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Contributes to phagocytic removal of apoptotic cells in many tissues. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Appears to participate in the O-acetylation of GD3 ganglioside sialic acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted
messages: Spleen, lung, heart, brain and muscle.
messages: The F5/8 type C 2 domain mediates high-affinity binding to phosphatidylserine-containing membranes.
messages: acrosome membrane

10116:Plaat5
gene id: 10116:Plaat5
uniprot id: Q4KLN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the H-rev107 family.
messages: Exhibits both phospholipase A1/2 and acyltransferase activities (By similarity). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (By similarity). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:17158102).
messages: Expressed in testis.
messages: cytosol

10116:Cyp26c1
gene id: 10116:Cyp26c1
uniprot id: D4AAL3
names: Similarity
messages: Belongs to the cytochrome P450 family.

10116:Slc30a6
gene id: 10116:Slc30a6
uniprot id: B2RZA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

10116:Oprk1
gene id: 10116:Oprk1
uniprot id: A6JFI3
uniprot id: P34975
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
messages: Interacts with NHERF1. Interacts with GABARAPL1 (By similarity).
messages: Interacts with NHERF1. Interacts with GABARAPL1.
messages: Membrane

10116:Ttll1
gene id: 10116:Ttll1
uniprot id: Q5PPI9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin polyglutamylase family.
messages: Catalytic subunit of a polyglutamylase complex which modifies tubulin, generating side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Probably involved in the side-chain elongation step of the polyglutamylation reaction rather than the initiation step. Modifies both alpha- and beta-tubulins with a preference for the alpha-tail. Unlike most polyglutamylases of the tubulin--tyrosine ligase family, only displays a catalytic activity when in complex with other proteins as it is most likely lacking domains important for autonomous activity. Part of the neuronal tubulin polyglutamylase complex. Mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility. Involved in respiratory motile cilia function through the regulation of beating asymmetry. Essential for sperm flagella biogenesis, motility and male fertility. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis.
messages: Gln-144 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate-chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation.
messages: Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1. Interacts with PCM1, CSTPP1 and LRRC49.
messages: cilium axoneme
messages: cilium basal body
messages: cytoskeleton
messages: flagellum

10116:P2rx3
gene id: 10116:P2rx3
uniprot id: A6HMS8
uniprot id: P49654
uniprot id: Q9R1K3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the P2X receptor family.
messages: Cell membrane
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Homotrimer (By similarity). Functional P2XRs are organized as homomeric and heteromeric trimers (PubMed:7566120).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated cation channel (PubMed:7566120, PubMed:7566119). Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception (By similarity).
messages: Receptor for ATP that acts as a ligand-gated ion channel.
messages: Selectively expressed in sensory ganglia.

10116:Fnta
gene id: 10116:Fnta
uniprot id: F7FMZ5
uniprot id: Q04631
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Activated by the AGRIN-induced phosphorylation which is mediated by MUSK.
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.
messages: Heterodimer of FNTA and FNTB (farnesyltransferase) (PubMed:10377218, PubMed:10673434, PubMed:11687658, PubMed:12374986, PubMed:12657282, PubMed:12667062, PubMed:15170324, PubMed:15451670, PubMed:18844669, PubMed:19219049, PubMed:22963166, PubMed:9065406, PubMed:9609683, PubMed:9657673, PubMed:9843427). Heterodimer of FNTA and PGGT1B (geranylgeranyltransferase) (PubMed:14609943).
messages: Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity).

10116:Nsfl1c
gene id: 10116:Nsfl1c
uniprot id: A0A0G2K911
uniprot id: A6KHI1
uniprot id: O35987
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NSFL1C family.
messages: Chromosome
messages: Golgi stack
messages: Highly expressed in heart, brain, spleen, lung, liver, muscle, kidney and testis.
messages: Highly expressed in pachytene spermatocytes during spermatogenesis.
messages: Nucleus
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP.
messages: Phosphorylated during mitosis. Phosphorylation inhibits interaction with Golgi membranes and is required for the fragmentation of the Golgi stacks during mitosis.
messages: Reduces the ATPase activity of VCP (PubMed:9824302, PubMed:9214505). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (PubMed:12411482). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (PubMed:10930451). Inhibits the activity of CTSL (in vitro) (By similarity). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (By similarity). Also, regulates spindle orientation during mitosis (By similarity).
messages: centrosome

10116:Txnrd2
gene id: 10116:Txnrd2
uniprot id: Q9Z0J5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Expressed in liver, kidney, adrenal gland and heart.
messages: Homodimer.
messages: Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (By similarity). Maintains mitochondrial thioredoxin in a reduced state. May play a role in redox-regulated cell signaling.
messages: Mitochondrion
messages: The active site is a redox-active disulfide bond. The selenocysteine residue is also essential for catalytic activity (By similarity).

10116:Ccdc81
gene id: 10116:Ccdc81
uniprot id: Q5XIN9
names: Subcellular Location Annotation
messages: centrosome

10116:Sucnr1
gene id: 10116:Sucnr1
uniprot id: A6JVL5
uniprot id: Q6IYF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in retina.
messages: G protein-coupled receptor for succinate able to mediate signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and the processes regulated (PubMed:15141213). Succinate-SUCNR1 signaling serves as a link between metabolic stress, inflammation and energy homeostasisn (By similarity). In macrophages, plays a range of immune-regulatory roles. During inflammation, succinate-SUCNR1 signaling may act as an anti-inflammatory mediator or boost inflammation depending on the inflammatory status of cells (By similarity). Hyperpolarizes M2 macrophages versus M1 phenotype through Gq signaling by regulating the transcription of genes involoved in immune function (By similarity). In activated M1 macrophages, plays a pro-inflammatory role in response to LPS (By similarity). Expressed in dendritic cells, where it is involved in the sensing of immunological danger and enhances immunity. Mediates succinate triggered intracelleular calcium mobilization, induces migratory responses and acts in synergy with Toll-like receptor ligands for the production of proinflammatory cytokines as well as an enhancement of antigen-specific activation of helper T cells (By similarity). In the small intestine, mediates the activation of tuft cells by dietary succinate and triggers type 2 immunity. In adipocytes, plays an important role in the control of energy metabolism. In response to succinate, controls leptin expression in an AMPK-JNK-CEBPA-dependent as well as circadian clock-regulated manner. In muscle tissue, is expressed in non-muscle cells and coordinates muscle remodeling in response to the succinate produced during exercise training in a paracrine manner (By similarity). In retina, acts as a mediator of vessel growth during retinal development. In response to succinate, regulates the production of angiogenic factors, including VEGF, by retinal ganglion neurons (PubMed:18836459).
messages: Membrane

10116:Nobox
gene id: 10116:Nobox
uniprot id: A6IFA6
uniprot id: D3ZXL8
names: Subcellular Location Annotation
messages: Nucleus

10116:Nfya
gene id: 10116:Nfya
uniprot id: A0A0G2KB97
uniprot id: A0A8I5Y9Y4
uniprot id: A6JIF2
uniprot id: P18576
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component BMAL1.
messages: Heterotrimer.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding (By similarity). Interacts with SP1; the interaction is inhibited by glycosylation of SP1. Interacts (via N-terminus) with ZHX2 (via homeobox domain). Interacts with ZFX3. Interacts with ZHX1 (By similarity).
messages: Nucleus

10116:Il3
gene id: 10116:Il3
uniprot id: A6HEH2
uniprot id: P97688
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-3 family.
messages: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.
messages: Secreted

10116:Lig3
gene id: 10116:Lig3
uniprot id: A0A096MKE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

10116:Sars2
gene id: 10116:Sars2
uniprot id: A6J9K5
uniprot id: D3ZM09
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

10116:Mapk13
gene id: 10116:Mapk13
uniprot id: Q32Q45
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Interacts with MAPK8IP2.

10116:Or2aj4b
gene id: 10116:Or2aj4b
uniprot id: D3ZAI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Mrgprd
gene id: 10116:Mrgprd
uniprot id: Q7TN41
uniprot id: W8W3F8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
messages: Cell membrane
messages: Co-expressed in the small diameter neurons with P2X3 and VR1 in dorsal root ganglia.
messages: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. The receptor couples with G-protein G(q) and G(i) (By similarity).
messages: Membrane

10116:Rbm4b
gene id: 10116:Rbm4b
uniprot id: Q64LC9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with TNPO3, which may mediate nuclear import of the protein.
messages: Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity).
messages: nucleolus

10116:Ccndbp1
gene id: 10116:Ccndbp1
uniprot id: Q5BK06
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCNDBP1 family.
messages: Cytoplasm
messages: Expression is induced by partial hepatectomy.
messages: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.
messages: May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription (By similarity).
messages: Nucleus
messages: Phosphorylated.

10116:Grpel2
gene id: 10116:Grpel2
uniprot id: A6IXI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

10116:Srxn1
gene id: 10116:Srxn1
uniprot id: A6KHM1
names: Similarity
messages: Belongs to the sulfiredoxin family.

10116:Lyar
gene id: 10116:Lyar
uniprot id: A6IJU1
uniprot id: Q6AYK5
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in testis (at protein level).
messages: Interacts with PRMT5; this interaction is direct. Interacts with GNL2 and RPL23A (By similarity). Interacts with nucleolin/NCL; this interaction is direct (By similarity). Interacts with phosphorylated IRF3; this interaction impairs IRF3 DNA-binding activity (By similarity).
messages: Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs. Also acts at the level of transcription regulation. Along with PRMT5, binds embryonic globin promoter (By similarity). Represses the expression of embryonic globin Hbb-y gene (By similarity). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and that encoding the small nucleolar RNA SNORD41. Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (By similarity). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (By similarity). In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines (By similarity). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells. Prevents NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity).
messages: The N-terminal zinc-finger domains are required for the appropriate production of 28S rRNA and the formation of pre-60S particles.
messages: nucleolus
messages: photoreceptor outer segment

10116:Gjc1
gene id: 10116:Gjc1
uniprot id: A0A654ICN4
uniprot id: A4GG66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: Ubiquitous.
messages: gap junction

10116:Penk
gene id: 10116:Penk
uniprot id: A6JFM8
uniprot id: P04094
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the opioid neuropeptide precursor family.
messages: Expressed in brain, heart and testis.
messages: Increases glutamate release in the striatum and decreases GABA concentration in the striatum.
messages: Increases glutamate release in the striatum.
messages: Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1 (PubMed:8624732). Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release (By similarity).
messages: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Probably cleaved by ACE.
messages: Processed and degraded by ACE.
messages: Processed by ACE to generate Met-enkephalin in the nucleus accumbens of the brain.
messages: Proenkephalin-A is cleaved by CTSL to generate Met-enkephalin.
messages: Secreted
messages: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
messages: chromaffin granule lumen

10116:Tma7
gene id: 10116:Tma7
uniprot id: A6I3B4
names: Similarity
messages: Belongs to the TMA7 family.

10116:Or1o11
gene id: 10116:Or1o11
uniprot id: Q6ZMA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Sult4a1
gene id: 10116:Sult4a1
uniprot id: A0A8I6AMX8
uniprot id: A6HTB0
uniprot id: A6HTB1
uniprot id: P63047
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS (By similarity).
messages: Belongs to the sulfotransferase 1 family.
messages: Cytoplasm
messages: Expressed at low levels in brains of 1-day old animals but increase to adult levels from 7-day old animals and remain at that level in adults.
messages: Expressed in the brain, not detected in the liver, kidney, spleen, heart, small intestine or testis.

10116:Or10al5b
gene id: 10116:Or10al5b
uniprot id: A0A8I6G8S3
uniprot id: A0A8I6GE03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Scp2
gene id: 10116:Scp2
uniprot id: P11915
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Contains a putative mitochondrial transit peptide at positions 1-20.
messages: Cytoplasm
messages: Expressed in liver (at protein level).
messages: In the N-terminal section; belongs to the thiolase-like superfamily. Thiolase family.
messages: Interacts with PEX5; the interaction is essential for peroxisomal import.
messages: Liver > intestine > brain > lung, colon, stomach, spleen, kidney, heart and ovary.
messages: Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis (By similarity). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (PubMed:8063752). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3 (PubMed:9553048) (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (PubMed:9553048).
messages: Mitochondrion
messages: Peroxisome
messages: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids (PubMed:9325339, PubMed:8063752). Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (PubMed:9325339, PubMed:8063752). Also active with medium and long straight chain 3-oxoacyl-CoAs (PubMed:9325339, PubMed:10706581). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (PubMed:8063752). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (PubMed:9553048).
messages: preSCP2, a protein with a molecular mass of about 15 kDa, is processed into its mature form (SCP2) by proteolytic cleavage of a 20 residue leader sequence after translocation into peroxisomes.

10116:Fgd6
gene id: 10116:Fgd6
uniprot id: A0A8I6G5H4
uniprot id: A6IG06
names: Subcellular Location Annotation
messages: cytoskeleton

10116:Tvp23a
gene id: 10116:Tvp23a
uniprot id: A6K4K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

10116:Btg1
gene id: 10116:Btg1
uniprot id: Q63073
names: Function
names: Similarity
names: Subunit
messages: Anti-proliferative protein.
messages: Belongs to the BTG family.
messages: Interacts with CNOT7 and CNOT8.

10116:Socs2
gene id: 10116:Socs2
uniprot id: O88582
names: Domain
names: Function
names: PTM
names: Subunit
messages: Interacts with IGF1R (By similarity). Associates with the Elongin BC complex (By similarity). Interacts with AREL1 and PRKCA (By similarity). Interacts with DCUN1D1 (By similarity).
messages: Phosphorylation at Ser-52 by PKC facilitates its ubiquitination and proteasomal degradation.
messages: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
messages: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
messages: Ubiquitinated; mediated by AREL1 and leading to its subsequent proteasomal degradation. Ubiquitination is dependent on phosphorylation at Ser-52, by PKC and is stimulated by LPS.

10116:Eif1b
gene id: 10116:Eif1b
uniprot id: B5DFN1
names: Similarity
messages: Belongs to the SUI1 family.

10116:Dph1
gene id: 10116:Dph1
uniprot id: B2RYK2
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.

10116:Alox12e
gene id: 10116:Alox12e
uniprot id: D3ZQF9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arachidonate 12-lipoxygenase activity is decreased when the pH decreases from 7.4 to 6.0.
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:23382512). Shows increasing catalytic activity within the series arachidonic acid < 5,8,11-eicosatrienoic acid < linoleic acid < 8,11,14-eicosatrienoic acid (By similarity).
messages: Cytoplasm

10116:Or5i1
gene id: 10116:Or5i1
uniprot id: A6HN02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Fam234a
gene id: 10116:Fam234a
uniprot id: Q5M7W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM234 family.
messages: Membrane

10116:Cyp19a1
gene id: 10116:Cyp19a1
uniprot id: A6J4K5
uniprot id: F1LPY2
names: Similarity
messages: Belongs to the cytochrome P450 family.

10116:Zdhhc24
gene id: 10116:Zdhhc24
uniprot id: A6HZ03
uniprot id: Q2TGI5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: Probable palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates.
messages: The DHHC domain is required for palmitoyltransferase activity.

10116:Ngp
gene id: 10116:Ngp
uniprot id: A6I3E3
uniprot id: D3ZY96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

10116:Or10a5
gene id: 10116:Or10a5
uniprot id: A6I7Q9
uniprot id: F1M8E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Shcbp1l
gene id: 10116:Shcbp1l
uniprot id: B1H291
uniprot id: F7EZY4
names: Subcellular Location Annotation
messages: spindle

10116:Ccl19
gene id: 10116:Ccl19
uniprot id: A6IIY6
uniprot id: D3ZI84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

10116:Rps17
gene id: 10116:Rps17
uniprot id: A6JCF2
uniprot id: P04644
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS17 family.
messages: Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: Cytoplasm
messages: Ubiquitinated at Lys-103 by RNF14 and RNF25 in response to ribosome collisions (ribosome stalling).
messages: nucleolus

10116:Nipal2
gene id: 10116:Nipal2
uniprot id: A6HR07
uniprot id: D3ZKE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

10116:Ugt1a5
gene id: 10116:Ugt1a5
uniprot id: A0A9K3Y841
uniprot id: Q6T5F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

10116:Olr1165
gene id: 10116:Olr1165
uniprot id: D3Z9G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Atf6
gene id: 10116:Atf6
uniprot id: G3V909
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: During unfolded protein response, a fragment of approximately 50 kDa containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 (MBTPS1, S1P) and site-2 (MBTPS2, S2P) proteases (By similarity).
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer and heterodimer with ATF6-beta. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC). Interacts also with the transcription factors GTF2I, YY1 and SRF.
messages: Interacts with THBS4 (via EGF-like 3; calcium-binding domain) which facilitates its processing, activation and nuclear translocation (By similarity). Interacts (via lumenal domain) with THBS1 (By similarity).
messages: Interacts with XBP1 isoform 2; the interaction occurs in a ER stress-dependent manner. Interacts with LACC1.
messages: N-glycosylated. The glycosylation status may serve as a sensor for ER homeostasis, resulting in ATF6 activation to trigger the unfolded protein response (UPR) (By similarity).
messages: Nucleus
messages: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane. Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR).
messages: The basic domain functions as a nuclear localization signal.
messages: The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.
messages: Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
messages: Ubiquitinated by RNF186 at Lys-139, which is required for pattern recognition receptor-induced unfolded protein response-associated outcomes.

10116:Ndufa5
gene id: 10116:Ndufa5
uniprot id: A6IE84
uniprot id: Q63362
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

10116:Gatad2a
gene id: 10116:Gatad2a
uniprot id: A6KA99
names: Subcellular Location Annotation
messages: Nucleus

10116:Or2ak5e
gene id: 10116:Or2ak5e
uniprot id: A0A8I6AJC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tmem196
gene id: 10116:Tmem196
uniprot id: Q5EB63
names: Subcellular Location Annotation
messages: Membrane

10116:Sfmbt2
gene id: 10116:Sfmbt2
uniprot id: A0A8I5Y8B8
uniprot id: A6JLT9
uniprot id: D4A643
names: Subcellular Location Annotation
messages: Nucleus

10116:Or14a257c
gene id: 10116:Or14a257c
uniprot id: D3ZBD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Pla2g15
gene id: 10116:Pla2g15
uniprot id: Q675A5
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Detected in alveolar macrophages (at protein level). Widely expressed. Expressed at highest levels in alveolar macrophages.
messages: Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:15294901). Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity) (PubMed:15294901). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines. Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines (By similarity). Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide (By similarity). Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress. Required for normal phospholipid degradation in alveolar macrophages with potential implications in pulmonary surfactant clearance (By similarity). At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (By similarity).
messages: Lysosome
messages: Membrane
messages: N-glycosylated. N-glycosylation is important for maturation of the enzyme and normal subcellular location.
messages: Secreted
messages: Transacylase activity is inhibited by MJ33.

10116:Masp2
gene id: 10116:Masp2
uniprot id: A0A0G2K392
uniprot id: A2VCV7
uniprot id: A6IU76
uniprot id: F7FHD3
uniprot id: Q9JJS8
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S1 family.
messages: Dimerization and MBL2 binding requires calcium ions.
messages: Highly expressed in liver. Secreted in plasma.
messages: Homodimer; disulfide-linked. Binds MBL2. Isoform 2 binds to MASP1. Binds SERPING1 (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: N-glycosylated.
messages: Secreted
messages: Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

10116:Ptk7
gene id: 10116:Ptk7
uniprot id: A6JIQ3
uniprot id: D3ZHG3
names: Subcellular Location Annotation
messages: Membrane

10116:Sftpc
gene id: 10116:Sftpc
uniprot id: A6HTK9
uniprot id: P11685
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
messages: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).
messages: surface film

10116:Pitpnb
gene id: 10116:Pitpnb
uniprot id: P53812
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.
messages: Catalyzes the transfer of phosphatidylinositol between membranes (PubMed:18636990). Also catalyzes the transfer of phosphatidylcholine and sphingomyelin between membranes (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (By similarity).
messages: Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting.
messages: Endoplasmic reticulum membrane
messages: Expressed abundantly in brain, kidney, liver, and lung, but in a lesser amount in testis.
messages: Golgi apparatus
messages: Golgi apparatus membrane
messages: Phosphatidylinositol transfer activity is inhibited by N-ethylmaleimide.

10116:Prpsap2
gene id: 10116:Prpsap2
uniprot id: A6HF87
uniprot id: O08618
uniprot id: Q6AZ40
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Binds to PRPS1 and PRPS2.
messages: Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.
messages: Ubiquitous.

10116:Ddx31
gene id: 10116:Ddx31
uniprot id: B1H297
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

10116:Kif9
gene id: 10116:Kif9
uniprot id: A0A8I6A1N2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

10116:Kat2a
gene id: 10116:Kat2a
uniprot id: A6HJ54
uniprot id: D4ACX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus
messages: centrosome

10116:Gdf1
gene id: 10116:Gdf1
uniprot id: A0A0U1RS23
uniprot id: A6KA58
names: Similarity
messages: Belongs to the TGF-beta family.

10116:Actl9b
gene id: 10116:Actl9b
uniprot id: Q6AY16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family.
messages: Interacts with ACTL7A.
messages: Testis-specic protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.
messages: acrosome
messages: perinuclear theca

10116:Glyatl1
gene id: 10116:Glyatl1
uniprot id: B1H250
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

10116:Atp2c2
gene id: 10116:Atp2c2
uniprot id: A6IZK4
uniprot id: Q8R4C1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway. Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Induces Ca(2+) influx independently of its ATP-driven pump function. At the basolateral membrane of mammary epithelial cells, interacts with Ca(2+) channel ORAI1 and mediates Ca(2+) entry independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May facilitate transepithelial transport of large quantities of Ca(2+) for milk secretion via activation of Ca(2+) influx channels at the plasma membrane and active Ca(2+) transport at the Golgi apparatus.
messages: Basolateral cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Cell membrane
messages: Interacts (via N-terminus) with ORAI1 (via N- and C-termini); this interaction regulates Ca(2+) influx at the plasma membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: trans-Golgi network membrane

10116:Fam83f
gene id: 10116:Fam83f
uniprot id: A6HSX5
uniprot id: D3ZAT7
names: Similarity
messages: Belongs to the FAM83 family.

10116:LOC100361143
gene id: 10116:LOC100361143
uniprot id: M0RA78
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

10116:Slc5a2
gene id: 10116:Slc5a2
uniprot id: P53792
uniprot id: Q8R520
uniprot id: Q8R521
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Appears on embryonic day 17 and gradually increases until day 19. Decreases between day 19 and birth.
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:7493971). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).
messages: Forms a heterodimer with PDZK1IP1; this interaction enhances the transporter activity over a hundred-fold.
messages: Glycosylated at a single site.
messages: Kidney, in proximal tubule S1 segments.
messages: Membrane

10116:Stard13
gene id: 10116:Stard13
uniprot id: A0A8I6AFY2
uniprot id: A0A8I6AGG1
uniprot id: A6KSV7
uniprot id: D3ZU63
uniprot id: T2C9V6
names: Subcellular Location Annotation
messages: Cytoplasm

10116:Cdx2
gene id: 10116:Cdx2
uniprot id: A0A9K3Y7D3
uniprot id: Q9ESV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

10116:Sds
gene id: 10116:Sds
uniprot id: P09367
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: By glucocorticoids and glucagon.
messages: Cytoplasm
messages: Homodimer.

10116:Pak5
gene id: 10116:Pak5
uniprot id: D4A280
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An autoinhibitory domain is present in the N-terminal region of the protein.
messages: Autophosphorylated when activated by CDC42/p21.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with MARK2, leading to inhibit MARK2 independently of kinase activity. Interacts with RHOD and RHOH (By similarity).
messages: Mitochondrion
messages: Nucleus
messages: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions (By similarity).

10116:P2rx7
gene id: 10116:P2rx7
uniprot id: A6J185
uniprot id: C8YIX5
uniprot id: Q64663
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel.
messages: Belongs to the P2X receptor family.
messages: Cell membrane
messages: Functional P2XRs are organized as homomeric and heteromeric trimers. Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 and PTPRB (By similarity). Interacts (via C-terminus) with EMP2 (By similarity).
messages: Membrane
messages: Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface.
messages: Phosphorylation results in its inactivation.
messages: Receptor for ATP that acts as a ligand-gated ion channel.
messages: Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.

10116:Trnt1
gene id: 10116:Trnt1
uniprot id: Q4VBH2
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

10116:Wdfy1
gene id: 10116:Wdfy1
uniprot id: A0A0G2K3L8
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

10116:Adcy2
gene id: 10116:Adcy2
uniprot id: P26769
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by forskolin (PubMed:1719547, PubMed:22906005, PubMed:24363043). Is not activated by calmodulin (PubMed:1719547). Inhibited by calcium ions, already at micromolar concentration. Activated by the G protein alpha subunit GNAS (PubMed:1719547, PubMed:7761832, PubMed:21596131). Activated by the G protein beta and gamma subunit complex (PubMed:7761832, PubMed:21596131, PubMed:22906005). Phosphorylation by RAF1 results in its activation (By similarity). Phosphorylation by PKC activates the enzyme (PubMed:22906005).
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:22906005, PubMed:24363043, PubMed:10427002, PubMed:1719547, PubMed:7761832, PubMed:21596131, PubMed:11087399, PubMed:15591060, PubMed:19243146, PubMed:16766715). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production (PubMed:24363043). Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (PubMed:22906005).
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in brain, olfactory epithelium and lung.
messages: Interacts with RAF1 (By similarity). Interacts with GNAS (PubMed:9417641, PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:19243146). Interacts with the G protein beta and gamma subunit complex (PubMed:21596131).
messages: Membrane
messages: Phosphorylated by RAF1 (By similarity).
messages: The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.

10116:Hba-a1
gene id: 10116:Hba-a1
uniprot id: A0A1K0FUB4
uniprot id: B1H216
uniprot id: P01946
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1 (PubMed:18077343). Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling (PubMed:18077343).
messages: Heterotetramer of two alpha chains and two beta chains.
messages: In rats there are two non-allelic alpha chains and two non-allelic beta chains. The alpha-1 chain sequence is shown.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: PubMed:8334153 incorrectly assigned their sequence fragment as a fatty acid-binding protein.
messages: Red blood cells.

10116:Atp6v1g1
gene id: 10116:Atp6v1g1
uniprot id: B2GUV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

10116:Atp5pf
gene id: 10116:Atp5pf
uniprot id: A6JL59
uniprot id: P21571
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

10116:Adissp
gene id: 10116:Adissp
uniprot id: Q4KM45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adipocyte-secreted protein (adipokine) that acts as a key regulator for white adipose tissue (WAT) thermogenesis and glucose homeostasis at least in part through activation of protein kinase A (PKA).
messages: Belongs to the ADISSP family.
messages: Secreted

10116:Tenm3
gene id: 10116:Tenm3
uniprot id: A0A8I6ABL2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HHIP family.
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:RT1-M1-4
gene id: 10116:RT1-M1-4
uniprot id: Q6MFZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Membrane

10116:Pdia6
gene id: 10116:Pdia6
uniprot id: A6HAU2
uniprot id: Q63081
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein disulfide isomerase family.
messages: Cell membrane
messages: Endoplasmic reticulum lumen
messages: May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.
messages: Melanosome
messages: Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with MICA on the surface of tumor cells, leading to MICA disulfide bond reduction which is required for its release from tumor cells. Interacts with ITGB3 following platelet stimulation. Interacts with ERN1; the interaction is direct. Interacts with EIF2AK3.

10116:Cyp2b1
gene id: 10116:Cyp2b1
uniprot id: B2GV28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

10116:Cmtm4
gene id: 10116:Cmtm4
uniprot id: D4A110
names: Subcellular Location Annotation
messages: Membrane

10116:Cyp2j10
gene id: 10116:Cyp2j10
uniprot id: B5DEP8
names: Similarity
messages: Belongs to the cytochrome P450 family.

10116:Sln
gene id: 10116:Sln
uniprot id: Q6SLE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcolipin family.
messages: Endoplasmic reticulum membrane
messages: Interacts with calcium ATPase ATP2A1/SERCA1. Interact with ATP2A2; the inhibition decreases ATP2A1 Ca(2+) affinity. Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2.
messages: Reversibly inhibits the activity of ATP2A1 and ATP2A2 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis (By similarity).
messages: Sarcoplasmic reticulum membrane

10116:Fam131b
gene id: 10116:Fam131b
uniprot id: A0A8I6AQS3
uniprot id: F8WFH6
uniprot id: Q568Z1
names: Similarity
messages: Belongs to the FAM131 family.

10116:Utp23
gene id: 10116:Utp23
uniprot id: A0A8I6A8S2
uniprot id: A6HRE2
names: Subcellular Location Annotation
messages: nucleolus

10116:Rabggtb
gene id: 10116:Rabggtb
uniprot id: A6HWN7
uniprot id: Q08603
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.
messages: Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding (PubMed:10745007, PubMed:12620235, PubMed:18399557, PubMed:18756270, PubMed:19894725, PubMed:22480322, PubMed:8505342, PubMed:22963166). The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp) (PubMed:11675392). The CHM:RGGT:Rab complex is destabilized by GGpp (PubMed:11675392). Interaction of RABGGTB with prenylated PTP4A2 precludes its association with RABGGTA and inhibits enzyme activity (By similarity). Interacts with CHODL (By similarity). Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction (By similarity).
messages: Most abundant in the heart, brain, spleen and liver. Less in the lung, muscle, kidney and testis; in these tissues, more abundant than the subunit alpha.
messages: The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM.

10116:Trappc6a
gene id: 10116:Trappc6a
uniprot id: A6J8P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

10116:Il4i1
gene id: 10116:Il4i1
uniprot id: A6JAS8
uniprot id: D3ZLJ6
uniprot id: D3ZN20
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

10116:Arsa
gene id: 10116:Arsa
uniprot id: F7FF93
uniprot id: Q32KK2
names: Similarity
messages: Belongs to the sulfatase family.

10116:Hck
gene id: 10116:Hck
uniprot id: P50545
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Expressed strongly in spleen and at very low levels in thymus.
messages: Golgi apparatus
messages: Interacts with ADAM15. Interacts with FASLG. Interacts with ARRB1 and ARRB2. Interacts with FCGR1A; the interaction may be indirect. Interacts with IL6ST. Interacts (via SH3 domain) with ELMO1. Interacts (via SH3 domain) with TP73. Interacts with YAP1. Interacts with ABL1 and ITGB1, and thereby recruits ABL1 to activated ITGB1. Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with CBL. Interacts with VAV1, WAS and RAPGEF1.Interacts (via SH3 domain) with WDCP.
messages: Isoform 2 palmitoylation at position 2 requires prior myristoylation. Palmitoylation at position 3 is required for caveolar localization of isoform 2.
messages: Lysosome
messages: Membrane
messages: Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS (By similarity).
messages: Nucleus
messages: Phosphorylated on several tyrosine residues. Autophosphorylated. Becomes rapidly phosphorylated upon activation of the immunoglobulin receptors FCGR1A and FCGR2A. Phosphorylation at Tyr-409 increases kinase activity. Phosphorylation at Tyr-520 inhibits kinase activity. Kinase activity is not required for phosphorylation at Tyr-520, suggesting that this site may be a target of other kinases (By similarity).
messages: Subject to autoinhibition, mediated by intramolecular interactions involving the SH2 and SH3 domains. Kinase activity is also regulated by phosphorylation at regulatory tyrosine residues. Phosphorylation at Tyr-409 is required for optimal activity. Phosphorylation at Tyr-520 inhibits kinase activity (By similarity).
messages: Ubiquitinated by CBL, leading to its degradation via the proteasome.
messages: caveola
messages: cytoskeleton
messages: cytosol
messages: focal adhesion
messages: podosome membrane
messages: secretory vesicle

10116:Ifnl3
gene id: 10116:Ifnl3
uniprot id: F1M3K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

10116:Snx20
gene id: 10116:Snx20
uniprot id: Q5BK61
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sorting nexin family.
messages: Cell membrane
messages: Cytoplasm
messages: Early endosome membrane
messages: Interacts with SELPLG. Interaction with SELPLG is controversial.
messages: May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion.
messages: Nucleus
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for localization to the endosomes.

10116:Snx8
gene id: 10116:Snx8
uniprot id: A6K1S7
uniprot id: D3ZUJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

10116:Endog
gene id: 10116:Endog
uniprot id: A6JTV7
uniprot id: F7FQ61
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

10116:Rptor
gene id: 10116:Rptor
uniprot id: D3ZDU2
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

10116:Lgr5
gene id: 10116:Lgr5
uniprot id: D4AC13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Identified in a complex composed of RNF43, LGR5 and RSPO1 (By similarity). Also interacts with other R-spondin ligands, including RSPO2, RSPO3 and RSPO4 (By similarity).
messages: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development (By similarity).
messages: trans-Golgi network membrane

10116:Naaa
gene id: 10116:Naaa
uniprot id: A6KK97
uniprot id: Q5KTC7
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autoproteolytic cleavage at pH 4.5 gives rise to the alpha and beta subunit. Cleavage gives rise to a conformation change that activates the enzyme. The same catalytic Cys residue mediates the autoproteolytic cleavage and subsequent hydrolysis of lipid substrates.
messages: Belongs to the acid ceramidase family.
messages: Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-stearoylethanolamine > N-oleoylethanolamine > N-linoleoylethanolamine > N-arachidonoylethanolamine.
messages: Expressed in brain, cecum, colon, heart, ileum, kidney, liver, lung, spleen, stomach, submaxillary gland, testis and thymus.
messages: Heterodimer of an alpha and a beta subunit, produced by autocatalytic cleavage.
messages: Heterodimer.
messages: Lysosome
messages: Membrane
messages: N-glycosylated. Tunicamycin treatment causes a reduction in specific activity against N-palmitoylethanolamine.
messages: Stimulated by DTT (PubMed:11463796, PubMed:22860206). Stimulated by nonionic detergent of the polyoxyethylenep-t-octylphenylether type (Triton X-100 or Nonidet P-40) whereas 3-[(3-cholamidopropyl)dimethylammonio]propane-1-sulfonate (CHAPS) and octyl alpha-D-glucopyranoside decrease the N-(long-chain-acyl)ethanolamine deacylase activity (PubMed:22860206). Polysorbate 20 (Tween 20) is inhibitory (PubMed:11463796). Stimulated by endogenous phospholipids such as choline- or ethanolamine-containing phospholipids, and dihydrolipoic acid (PubMed:22860206).

10116:Hoxc4
gene id: 10116:Hoxc4
uniprot id: A6KCZ2
uniprot id: D3ZK87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

10116:Fabp4
gene id: 10116:Fabp4
uniprot id: F7FMV4
uniprot id: Q9R290
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

10116:Trmt10c
gene id: 10116:Trmt10c
uniprot id: Q5U2R4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
messages: Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3. Interacts with HSD17B10/MRPP2; forming the MRPP1-MRPP2 subcomplex of the mitochondrial ribonuclease P complex. Interacts with GRSF1.
messages: Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation. Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity. The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit. The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme. In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.
messages: mitochondrion nucleoid

10116:Arvcf
gene id: 10116:Arvcf
uniprot id: B4F7F3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the beta-catenin family.
messages: Component of a ribonucleoprotein complex containing mRNAs and RNA-binding proteins including DDX5, HNRNPH2 and SRSF1 as well as ARVCF (By similarity). Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain). Interacts with CCDC85B (By similarity).
messages: Contributes to the regulation of alternative splicing of pre-mRNAs.
messages: Cytoplasm
messages: Expressed in optic nerve sheath envelope (at protein level) (PubMed:29445566). Expressed in heart (at protein level) (PubMed:31384490).
messages: Nucleus
messages: adherens junction

10116:Tnfrsf9
gene id: 10116:Tnfrsf9
uniprot id: A0A9K3Y716
uniprot id: Q4V895
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Rnpc3
gene id: 10116:Rnpc3
uniprot id: A0A8L2QC18
uniprot id: B2GV85
uniprot id: Q4G055
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7 (By similarity).
messages: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.
messages: Nucleus
messages: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA (By similarity).
messages: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA.

10116:Hmgcl
gene id: 10116:Hmgcl
uniprot id: A6IT78
uniprot id: P97519
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: In suckling rat, highest levels in liver and in intestine. Lower levels in heart, kidney and cerebellum. Weak expression in brain cortex, medulla and midbrain. Levels decrease slightly during weaning.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.
messages: Mitochondrion matrix
messages: Peroxisome

10116:Slc35e1
gene id: 10116:Slc35e1
uniprot id: P0C6B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35E subfamily.
messages: Membrane
messages: Putative transporter.

10116:Cyp2d3
gene id: 10116:Cyp2d3
uniprot id: A6HT75
uniprot id: P12938
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

10116:Pycr3
gene id: 10116:Pycr3
uniprot id: A6HS37
uniprot id: Q5PQJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Cytoplasm
messages: Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline.
messages: Homodecamer; composed of 5 homodimers.

10116:Mllt1
gene id: 10116:Mllt1
uniprot id: A0A8I6AH62
uniprot id: A6KQU1
names: Subcellular Location Annotation
messages: Nucleus

10116:Spata2
gene id: 10116:Spata2
uniprot id: Q66HP6
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SPATA2 family.
messages: Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis. Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (By similarity). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity).
messages: Cytoplasm
messages: During testicular development (from 2 to 45 days of age), expressed from 14 days and then increases steadily with an advancement of age.
messages: Expressed in the testis and to a lesser extent in the brain, while skeletal muscle and kidney show weak expression.
messages: Interacts (via the PIM motif) with RNF31/HOIP (via the PUB domain); the interaction is direct. Interacts (via the PUB domain) with CYLD; the interaction is direct.
messages: Nucleus
messages: Up-regulated following FSH treatment.

10116:Lrrc8c
gene id: 10116:Lrrc8c
uniprot id: Q498T9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Heterohexamer (By similarity). Oligomerizes with other LRRC8 proteins (LRRC8A, LRRC8B, LRRC8D and/or LRRC8E) to form a heterohexamer (Probable). Detected in a channel complex that contains LRRC8A, LRRC8C and LRRC8E (By similarity). In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist (Probable).
messages: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:28833202). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:28833202).
messages: The cytoplasmic N-terminus preceding the first transmembrane (residues 1-22) regulates volume-regulated anion channel (VRAC) conductance, ion permeability and inactivation gating.
messages: The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins.

10116:S1pr1
gene id: 10116:S1pr1
uniprot id: A6HV78
uniprot id: P48303
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: First detected at embryonic day 15. At postnatal day 14 detected in skin, spleen, liver, kidney, heart, testicle, lung and brain. At adulthood is most abundant in brain.
messages: G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury (By similarity).
messages: Interacts with GNAI1 and GNAI3.
messages: Membrane
messages: Membrane raft
messages: Palmitoylated by ZDHHC5. Palmitoylation is required for targeting to plasma membrane, enabling G(i) coupling.

10116:Flad1
gene id: 10116:Flad1
uniprot id: D4A4P4
names: Function
names: Similarity
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

10116:Cpeb1
gene id: 10116:Cpeb1
uniprot id: A0A0G2K5E3
uniprot id: A6JCF8
uniprot id: P0C279
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RRM CPEB family.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Expressed in hippocampus and cerebral cortex (at protein level). Expressed in hippocampus (dentate gyrus and CA1-CA4 regions), cerebellum (Purkinje cells), cortex, visual cortex (layers 1 and 2), mesencephalon, diencephalon and brain stem.
messages: Interacts with kinesin, dynein, APLP1, APLP2, TENT2/GLD2 and APP. Both phosphorylated and non phosphorylated forms interact with APLP1 (By similarity). Interacts with TENT4B; the interaction is required for TENT4B-mediated translational control (By similarity).
messages: Membrane
messages: P-body
messages: Phosphorylated on serine/threonine residues by AURKA within positions 165 and 196. Phosphorylation and dephosphorylation on Thr-171 regulates cytoplasmic polyadenylation and translation of CPE-containing mRNAs. Phosphorylation on Thr-171 by AURKA and CAMK2A activates CPEB1. Phosphorylation on Thr-171 may be promoted by APLP1. Phosphorylation increases binding to RNA (By similarity).
messages: Postsynaptic density
messages: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry.
messages: Synapse
messages: The 2 RRM domains and the C-terminal region mediate interaction with CPE-containing RNA. The interdomain linker (411-429) acts as a hinge to fix the relative orientation of the 2 RRMs. The ZZ domain (509-566) coordinates 2 Zn ions and is probably implicated in mediating interactions with other proteins in addition to increasing the affinity of the RRMs for the CPEs. A continuous hydrophobic interface is formed between the 2 RRM.

10116:LOC500460
gene id: 10116:LOC500460
uniprot id: D4A252
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Olr1633
gene id: 10116:Olr1633
uniprot id: A0A8I5YBU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ak3
gene id: 10116:Ak3
uniprot id: A0A8I6G902
uniprot id: P29411
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

10116:Klhl12
gene id: 10116:Klhl12
uniprot id: Q8R2H4
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: COPII-coated vesicle
messages: Component of the BCR(KLHL12) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL12 and RBX1. This complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A. Interacts with DRD4, KLHL2 and SEC31A. Interacts with PEF1 and PDCD6/ALG-2; interaction takes place in response to cytosolic calcium increase and leads to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B).
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export. As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins.
messages: The BTB domain is required for interaction with CUL3.
messages: Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteasome: ubiquitination by the SCF(FBXL17) complex takes place when aberrant BTB domain dimers are formed.

10116:Snx25
gene id: 10116:Snx25
uniprot id: A6JPP4
names: Similarity
messages: Belongs to the sorting nexin family.

10116:Runx1t1
gene id: 10116:Runx1t1
uniprot id: A0A0G2K0G0
uniprot id: A0A8I6AB42
uniprot id: A0A8I6G5L4
uniprot id: A6II90
uniprot id: A6II91
uniprot id: D3ZWZ8
names: Similarity
messages: Belongs to the CBFA2T family.

10116:Or4c117
gene id: 10116:Or4c117
uniprot id: A0A8I6A892
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tgfb1i1
gene id: 10116:Tgfb1i1
uniprot id: A0A8I5ZLR8
uniprot id: A6I9Z1
uniprot id: A6I9Z3
uniprot id: Q99PD6
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the paxillin family.
messages: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways.
messages: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.
messages: Homooligomer (By similarity). Interacts with PPARG (By similarity). Interacts with TRAF4 (By similarity). Interacts with CRIP2 (By similarity). Interacts with HSPB1 (PubMed:11546764). Interacts with ILK (By similarity). Interacts with LIMS1 and LIMS2 (By similarity). Interacts with NCK2 (PubMed:10330411). Interacts with NUDT16L1 (By similarity). Interacts with PAK (PubMed:10330411). Interacts with PTPN12 (By similarity). Interacts with TCF3 (By similarity). Interacts with TCF7L2 (By similarity). Interacts with VCL (By similarity). Interacts (via LD motif 3) with GIT1 (PubMed:12153727). Also interacts with GIT2 (PubMed:10330411). Forms a complex with ARHGEF7 (PubMed:10330411). Interacts with AR/androgen receptor in a ligand-dependent manner (By similarity). Interacts with CSK (By similarity). Interacts with PTK2/FAK1 and PTK2B/PYK2 (PubMed:9422762, PubMed:10330411, PubMed:16546139). Interacts with SLC6A3 and SLC6A4 (By similarity). Interacts with NR3C1 (By similarity). Interacts with SMAD3 (By similarity). Interacts with MAPK15 (By similarity). Interacts with SRC (By similarity). Interacts with LYN (By similarity). Interacts with talin (By similarity). Interacts (via LIM zinc-binding domain 2) with CBLC (via RING-type zinc finger); the interaction is direct and enhances CBLC E3 ubiquitin-protein ligase activity (By similarity). Interacts with PARVA (PubMed:11134073). Interacts with PXN (PubMed:16546139).
messages: Nucleus matrix
messages: Phosphorylated by gonadotropin-releasing hormone-activated SRC.
messages: Strongly expressed in large intestine, lung, spleen, testis, uterus and to a lower extent in brain, kidney and liver (at protein level). In brain, expressed by neuronal and non neuronal cells (at protein level).
messages: The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.
messages: The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4 domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1, homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with PTPN12 (By similarity).
messages: Up-regulated by retinoic acid.
messages: cytoskeleton
messages: focal adhesion

10116:Or4l1
gene id: 10116:Or4l1
uniprot id: A6KE91
uniprot id: D3ZSI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ube3a
gene id: 10116:Ube3a
uniprot id: A0A8I5ZM14
uniprot id: F1M7B8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
messages: Nucleus

10116:Sostdc1
gene id: 10116:Sostdc1
uniprot id: Q642G2
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sclerostin family.
messages: Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling.
messages: Highly expressed in epidermis, dermis and the outermost periderm layer in the 17 day post-coitum (dpc).
messages: Highly expressed within the maximally sensitized/receptive endometrium. Weakly expressed in brain, kidney and the female reproductive tract. Expressed in the dermal papilla (DP) and at high level in the precortex of both anagen vibrissae and pelage follicles. Dynymic expression during the hair cycle.
messages: Interacts with BMP2, BMP4, BMP6 and BMP7 with high affinity.
messages: Secreted
messages: Up-regulated at day 5 pregnant or pseudopregnant of the uterine glandular epithelial cells, at time of maximal sensitization for the decidual cell reaction. Down-regulated at day 6 refractory uterus.

10116:Tspan8
gene id: 10116:Tspan8
uniprot id: A6IGL8
uniprot id: O55158
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

10116:Ptdss1
gene id: 10116:Ptdss1
uniprot id: Q5PQL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity). Catalyzes mainly the conversion of phosphatidylcholine but also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity).
messages: Endoplasmic reticulum membrane

10116:Asb8
gene id: 10116:Asb8
uniprot id: B5DF17
uniprot id: F7F2V9
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

10116:Usp47
gene id: 10116:Usp47
uniprot id: B2GVC1
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

10116:Caly
gene id: 10116:Caly
uniprot id: A6HXF2
uniprot id: P58821
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NSG family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Expressed exclusively in neurons (at protein level). In all age groups, expressed at significantly higher levels in the medial prefrontal and orbital frontal cortices of spontaneously hypertensive rats (SHR), a model of attention deficit-hyperactivity disorder, than Wistar Kyoto (WKY) animals. In the motor cortex, dorsal striatum and nucleus accumbens, expression is significantly elevated in SHR only in younger animals.
messages: Interacts with CLTA.
messages: Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.
messages: Levels decrease significantly with age.
messages: The human ortholog was originally thought to interact with the D1 dopamine receptor (DRD1) and to play a role in potentiating calcium ion-dependent signaling but this work was later retracted.

10116:Pde6a
gene id: 10116:Pde6a
uniprot id: A6IXG6
uniprot id: D3Z8C9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

10116:Pld5
gene id: 10116:Pld5
uniprot id: F1MA92
names: Similarity
messages: Belongs to the phospholipase D family.

10116:C2
gene id: 10116:C2
uniprot id: Q6MG73
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

10116:Scg2
gene id: 10116:Scg2
uniprot id: A0A8I6A821
uniprot id: A6JW74
uniprot id: G3V7X2
uniprot id: P10362
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Binds calcium with a low-affinity.
messages: Brain. Expression in the pituitary is restricted to the anterior lobe. Expression in the hypothalamus is observed in the neuronal cells and neurons of arcuate nucleus, supraoptic nucleus and median eminence (at protein level).
messages: Interacts with Secretogranin III/SCG3.
messages: Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
messages: Secreted

10116:RGD1559575
gene id: 10116:RGD1559575
uniprot id: F1LVT9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

10116:Tas2r118
gene id: 10116:Tas2r118
uniprot id: A6IE78
uniprot id: Q9JKU0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Cell membrane
messages: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in the antrum and fundus (part of the stomach), duodenum and in gastric endocrine cells.
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
messages: Interacts with RTP3 and RTP4.
messages: Membrane
messages: Several bitter taste receptors are expressed in a single taste receptor cell.

10116:Hrk
gene id: 10116:Hrk
uniprot id: P62817
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with BCL2 and BCL2L1. Interacts with C1QBP (By similarity).
messages: Membrane
messages: Mitochondrion
messages: Promotes apoptosis.
messages: The BH3 motif is required for the induction of cell death.

10116:Ntsr1
gene id: 10116:Ntsr1
uniprot id: A6KM97
uniprot id: P20789
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.
messages: Cell membrane
messages: Detected in brain and small intestine.
messages: G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:23051748, PubMed:24453215, PubMed:26205105). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (By similarity).
messages: Interacts (palmitoylated form) with GNA11.
messages: Membrane
messages: Membrane raft
messages: N-glycosylated.
messages: Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment.
messages: The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembrane regions TM6 and TM7.

10116:Bles03
gene id: 10116:Bles03
uniprot id: Q566Q8
names: Similarity
messages: Belongs to the UPF0696 family.

10116:Mr1
gene id: 10116:Mr1
uniprot id: O19477
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Polymorphism
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells. In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (By similarity). Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively (By similarity). May present microbial antigens to various MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin. Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (By similarity). During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (By similarity). Acts as an immune sensor of cancer cell metabolome. May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR on a non-MAIT CD8-positive T cell clone, triggering T cell-mediated killing of a wide range of cancer cell types (By similarity).
messages: Cell membrane
messages: Does not appear to be polymorphic.
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Expressed in kidney, liver, testis, spleen, thymus, brain, and heart.
messages: Golgi apparatus membrane
messages: Heterotrimer that consists of MR1, B2M and a metabolite antigen. Forms reversible covalent Schiff base complexes with the microbial metabolite, which serves as a molecular switch triggering complete folding, stable association with B2M and translocation of the ternary complex from endoplasmic reticulum to the plasma membrane. On antigen-presenting cells, the ternary complex interacts with TCR on CD8-positive T cells. The molecular machinery involved in antigen processing remains unknown, but appears to be TAP1-TAP2 and proteasome-independent. Structurally, MR1-B2M heterodimer adopts a topology similar to classical MHC class I molecules, with alpha-1 and alpha-2 domains of MR1 forming the antigen-binding cleft composed of two alpha-helices resting on a floor of 7-stranded anti-parallel beta-pleated sheet. The ribityl moiety of pyrimidine-based antigens is recognized by Tyr-95 residue in the CDR3 alpha loop of the invariant TRAV1-2 TCR.
messages: Late endosome membrane
messages: MR1 is detected in an open versus folded conformation. Only the folded MR1 conformer activates MAIT cells (By similarity).
messages: N-glycosylated.
messages: The alpha-1 domain is a structural part of antigen-binding cleft.
messages: The alpha-2 domain is a structural part of antigen-binding cleft.

10116:Tsen15
gene id: 10116:Tsen15
uniprot id: A6ICT3
uniprot id: D3ZFW1
names: Similarity
messages: Belongs to the SEN15 family.

10116:Ccdc89
gene id: 10116:Ccdc89
uniprot id: B2RZ86
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC89 family.
messages: Cytoplasm
messages: Interacts with HEY1.
messages: Nucleus

10116:Rhox7
gene id: 10116:Rhox7
uniprot id: Q4TU76
names: Subcellular Location Annotation
messages: Nucleus

10116:Nxf1
gene id: 10116:Nxf1
uniprot id: O88984
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: Heterodimer (via NTF2 domain) with NXT1. The formation of NXF1-NXT1 heterodimers is required for the NXF1-mediated nuclear mRNA export. Forms a complex with RANBP2/NUP358, NXT1 and RANGAP1. Associates with the exon junction complex (EJC). Associates with the transcription/export (TREX) complex. Found in a mRNA complex with UPF3A and UPF3B. Found in a post-splicing complex with RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Interacts (via N-terminus) with DHX9 (via N-terminus); this interaction is direct and negatively regulates NXF1-mediated nuclear export of constitutive transport element (CTE)-containing cellular mRNAs. Interacts with FYTTD1/UIF. Interacts with EIF4A3. Interacts with NUP42. Interacts with ALYREF/THOC4. Interacts with CHTOP. Interacts with FRG1 (via N-terminus). Interacts with LUZP4. Interacts with FMR1; the interaction occurs in a mRNA-dependent and polyribosomes-independent manner in the nucleus. Interacts with CPSF6 (via N-terminus); this interaction is direct. Interacts with RBM15. Interacts with RBM15B. Interacts with MCM3AP; this interaction is not mediated by RNA (By similarity). Interacts with DDX3X (via C-terminus); this interaction may be partly involved in DDX3X nuclear export and in NXF1 localization to stress granules. Interacts with PABPC1/PABP1 (By similarity).
messages: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export.
messages: Nucleus envelope
messages: Nucleus speckle
messages: Stress granule
messages: The NTF2 domain is functional only in the presence of NXT1 and is essential for the export of mRNA from the nucleus. It inhibits RNA binding activity through an intramolecular interaction with the N-terminal RNA binding domain (RBD); the inhibition is removed by an association with the TREX complex, specifically involving ALYREF/THOC4 and THOC5.
messages: The RNA-binding domain is a non-canonical RNP-type domain.
messages: The TAP-C domain mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF1 to the nuclear rim. The conserved loop 594-NWD-596 of the TAP-C domain has a critical role in the interaction with nucleoporins.
messages: The leucine-rich repeats are essential for the export of mRNA from the nucleus.
messages: The minimal CTE binding domain consists of an RNP-type RNA binding domain (RBD) and leucine-rich repeats.
messages: The nucleoporin binding domain consists of a NTF2 domain (also called NTF2-like domain) and a TAP-C domain (also called UBA-like domain). It has 2 nucleoporin-FG-repeats binding sites (one in the NTF2 and the other in the TAP-C domain) which contribute to nucleoporin association and act synergistically to export cellular mRNAs.
messages: nuclear pore complex
messages: nucleoplasm

10116:Rims1
gene id: 10116:Rims1
uniprot id: Q9JIR4
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Highly expressed in hippocampus, brain cortex, cerebellum and olfactory bulb. Detected at lower levels in midbrain, hindbrain and spinal cord. Detected retina and in spinal cord motor neurons.
messages: Interacts with RAB3C, RAB10, RAB26 and RAB37 (By similarity). Binds SNAP25, SYT1 and CACNA1B. Interaction with SYT1 is enhanced by calcium ions. Interaction with SNAP25 is weaker in the presence of calcium ions. Binds RAB3A, RAB3B and RAB3D that have been activated by GTP-binding. Binds UNC13A. Interacts with TSPOAP1 and RIMBP2. Interacts with PPFIA3 and PPFIA4. Interacts with ERC1.
messages: Phosphorylated by BRSK1.
messages: Presynaptic cell membrane
messages: Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Plays a role in dendrite formation by melanocytes.
messages: Synapse

10116:Ackr4
gene id: 10116:Ackr4
uniprot id: A6I2L5
uniprot id: G3V9V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

10116:Cdk8
gene id: 10116:Cdk8
uniprot id: A6K1D1
names: Similarity
messages: Belongs to the protein kinase superfamily.

10116:Lipo1
gene id: 10116:Lipo1
uniprot id: D3ZUQ1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

10116:Tas2r126
gene id: 10116:Tas2r126
uniprot id: A6IF77
uniprot id: Q9JKE7
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Expressed in the duodenum, antrum and fundus (part of the stomach).
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
messages: This protein was previously referred to as T2R26 or T2R12 but is now considered to be the ortholog of human TAS2R41.

10116:Hapln4
gene id: 10116:Hapln4
uniprot id: A6KA91
uniprot id: D3Z9H2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Sema6d
gene id: 10116:Sema6d
uniprot id: A6HPV2
uniprot id: D3ZDA2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Ifnb1
gene id: 10116:Ifnb1
uniprot id: A0A7R8GV74
uniprot id: P70499
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha/beta interferon family.
messages: Monomer.
messages: Secreted
messages: This beta interferon does not have a disulfide bond.
messages: Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (By similarity). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity).

10116:Gpat4
gene id: 10116:Gpat4
uniprot id: B1WBM4
uniprot id: Q0ZFS7
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

10116:Lyn
gene id: 10116:Lyn
uniprot id: A6JFK8
uniprot id: A6JFK9
uniprot id: Q07014
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated (By similarity). Phosphorylated on tyrosine residues in response to KIT signaling (By similarity). Phosphorylation at Tyr-397 is required for optimal activity (By similarity). Phosphorylation at Tyr-508 inhibits kinase activity (By similarity). Phosphorylated at Tyr-508 by CSK (By similarity). Dephosphorylated by PTPRC/CD45 (By similarity). Becomes rapidly phosphorylated upon activation of the B-cell receptor and the immunoglobulin receptor FCGR1A (By similarity). Phosphorylated in response to integrin ITGB1 in B-cells (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Detected in spleen (at protein level). Expressed predominantly in B-lymphoid and myeloid cells.
messages: Golgi apparatus
messages: Interacts with TEC. Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with LIME1 and with CD79A upon activation of the B-cell antigen receptor. Interacts with the B-cell receptor complex. Interacts with phosphorylated THEMIS2. Interacts with EPOR. Interacts with MS4A2/FCER1B. Interaction (via the SH2 and SH3 domains) with MUC1 is stimulated by IL7 and the subsequent phosphorylation increases the binding between MUC1 and CTNNB1/beta-catenin. Interacts with ADAM15. Interacts with NDFIP2 and more weakly with NDFIP1. Interacts with FASLG. Interacts with KIT. Interacts with HCLS1. Interacts with FCGR2B. Interacts with FCGR1A; the interaction may be indirect. Interacts with CD19, CD22, CD79A and CD79B. Interacts (via SH3 domain) with CBLC, PPP1R15A and PDE4A. Interacts with TGFB1I1. Interacts (via SH3 domain) with PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase; this interaction enhances phosphatidylinositol 3-kinase activity. Interacts with CSF2RB, the common subunit of the IL3, IL5 and CSF2 receptors. Interacts with PAG1; identified in a complex with PAG1 and STAT3. Interacts with ABL1. Interacts with PTPN6/SHP-1. Interacts (via SH3 domain) with SCIMP (via proline-rich region) (By similarity). This interaction facilitates the phosphorylation of SCIMP 'Tyr-96', which enhances binding of SCIMP to TLR4, and consequently the phosphorylation of TLR4 in response to stimulation by lipopolysaccharide in macrophages (By similarity). Interacts with LPXN (via LD motif 3) and the interaction is induced upon B-cell antigen receptor (BCR) activation. Interacts (via SH3-domain) with ANKRD54 (via ankyrin repeat region) in an activation-independent status of LYN. Forms a multiprotein complex with ANKRD54 and HCLS1 (By similarity). Interacts (via SH2 and SH3 domains) with UNC119; leading to LYN activation (By similarity). Interacts with CD36. Interacts with LYN (By similarity). Interacts with SKAP1 and FYB1; this interaction promotes the phosphoryl…
messages: Membrane
messages: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylati…
messages: Nucleus
messages: Subject to autoinhibition, mediated by intramolecular interactions between the SH2 domain and the C-terminal phosphotyrosine. Phosphorylation at Tyr-397 is required for optimal activity. Phosphorylated by CSK at Tyr-508; phosphorylation at Tyr-508 inhibits kinase activity. Kinase activity is modulated by dephosphorylation by PTPRC/CD45.
messages: The protein kinase domain plays an important role in its localization in the cell membrane.
messages: Ubiquitinated. Ubiquitination is SH3-dependent (By similarity).
messages: perinuclear region

10116:Atp6v0b
gene id: 10116:Atp6v0b
uniprot id: A6JZF2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

10116:Foxe3
gene id: 10116:Foxe3
uniprot id: Q63250
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (By similarity). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (By similarity).

10116:Met
gene id: 10116:Met
uniprot id: A0A9K3Y8B9
uniprot id: P97523
uniprot id: Q2IBC7
names: Activity Regulation
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated in response to ligand binding on Tyr-1235 and Tyr-1236 in the kinase domain leading to further phosphorylation of Tyr-1350 and Tyr-1357 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1350 and Tyr-1366. Dephosphorylated by PTPN1 and PTPN2 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: By interleukin-6 and acute acid-induced gastric injury. Inhibited by prolactin.
messages: Expressed at highest levels in lung, liver and kidney, also expressed in stomach, intestine, spleen, testis and brain. Not expressed in heart or muscle.
messages: Expression is down-regulated during pregnancy and is virtually undetectable during lactation. Expression progressively increases post-lactation.
messages: Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1357, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity. Interacts with tensin TNS3 (By similarity). Interacts (when phosphorylated) with tensin TNS4 (via SH2 domain); the interaction increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation (By similarity).
messages: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: O-mannosylation of IPT/TIG domains by TMEM260 is required for protein maturation. O-mannosylated residues are composed of single mannose glycans that are not elongated or modified.
messages: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
messages: The beta-propeller Sema domain mediates binding to HGF.
messages: The kinase domain is involved in SPSB1 binding.
messages: Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity).

10116:Necab2
gene id: 10116:Necab2
uniprot id: F1LQY6
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in the striatum; predominantly in the caudate putamen. Expressed in hippocampus; particularly strong in the CA1 area. Expressed in the spinal dorsal horn with especially strong expression in lamina IIi; found in excitory synaptic boutons (at protein level).
messages: Interacts (calcium-dependent) with ADORA2A and GRM5.
messages: May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.
messages: axon
messages: dendrite

10116:Dlc1
gene id: 10116:Dlc1
uniprot id: A0A0G2K9I2
uniprot id: A0A8I5ZJE0
uniprot id: A6IVJ9
names: Subcellular Location Annotation
messages: Cytoplasm

10116:Snx10
gene id: 10116:Snx10
uniprot id: Q5BJX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

10116:Irx6
gene id: 10116:Irx6
uniprot id: A6KD59
uniprot id: D4A7R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

10116:Abat
gene id: 10116:Abat
uniprot id: A6K4M1
uniprot id: P50554
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 [2Fe-2S] cluster per homodimer.
messages: Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively (PubMed:10447691). Can also convert delta-aminovalerate and beta-alanine (PubMed:10447691).
messages: Homodimer; disulfide-linked.
messages: Mitochondrion matrix

10116:Rexo2
gene id: 10116:Rexo2
uniprot id: A0A0G2K038
uniprot id: A6J494
uniprot id: A6J495
uniprot id: Q5U1X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (By similarity). Binds and degrades longer oligonucleotides with a lower affinity (By similarity). Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (By similarity). Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (By similarity). Essential for embryonic development (By similarity).
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm
messages: Homodimer (By similarity). Homotetramer (By similarity).
messages: Mitochondrion
messages: Mitochondrion intermembrane space
messages: Mitochondrion matrix
messages: Nucleus

10116:Cyp24a1
gene id: 10116:Cyp24a1
uniprot id: A6JXS6
uniprot id: Q09128
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24-oxidation pathway, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:2026586, PubMed:16617161, PubMed:10231362). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid (PubMed:10231362, PubMed:16617161). Hydroxylates at C-24 or C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol (PubMed:25727742). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:2026586).
messages: Belongs to the cytochrome P450 family.
messages: Mitochondrion

10116:Hbs1l
gene id: 10116:Hbs1l
uniprot id: Q6AXM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.
messages: Component of the Pelota-HBS1L complex, also named Dom34-Hbs1 complex, composed of PELO and HBS1L. Interacts with the SKI complex.
messages: Cytoplasm
messages: GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.

10116:Dusp6
gene id: 10116:Dusp6
uniprot id: A6IG82
uniprot id: Q64346
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Cytoplasm
messages: Expressed in lung, heart, brain, and kidney, but not significantly in skeletal muscle or testis.
messages: Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:8626780). Implicated in muscle and neuronal differentiation (PubMed:8631996). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity).
messages: Interacts with MAPK1/ERK2.

10116:Hmmr
gene id: 10116:Hmmr
uniprot id: Q9WUF7
names: Subcellular Location Annotation
messages: spindle

10116:Atxn1
gene id: 10116:Atxn1
uniprot id: A6J718
uniprot id: Q63540
names: Domain
names: Function
names: PTM
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATXN1 family.
messages: Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved brain development.
messages: Cytoplasm
messages: Homooligomer. Interacts with CIC. Interacts with ANP32A, PQBP1, UBQLN4, ATXN1L and USP7. Directly interacts with RBPJ; this interaction is disrupted in the presence of Notch intracellular domain. Competes with ATXN1L for RBPJ-binding. Found in a complex with CIC and ATXN1L.
messages: Nucleus
messages: Phosphorylation at Ser-749 increases the pathogenicity of proteins with an expanded polyglutamine tract.
messages: Sumoylation is dependent on nuclear localization and phosphorylation at Ser-749. It is reduced in the presence of an expanded polyglutamine tract.
messages: The AXH domain is required for interaction with CIC.
messages: The rat poly-Gln region is very limited in comparison to human ATXN1 and is not polymorphic.
messages: Ubiquitinated by UBE3A, leading to its degradation by the proteasome.

10116:Kcnj11
gene id: 10116:Kcnj11
uniprot id: A6JBB1
uniprot id: P70673
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Interacts with ABCC9/SUR2 (By similarity). Interacts with ABCC8/SUR.
messages: Membrane
messages: Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity.
messages: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity).

10116:H2ac4
gene id: 10116:H2ac4
uniprot id: A6KN90
uniprot id: D3ZVK7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

10116:Hoxd10
gene id: 10116:Hoxd10
uniprot id: A6HMD0
uniprot id: D4ACD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

10116:Tenm2
gene id: 10116:Tenm2
uniprot id: Q9R1K2
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.
messages: Derives from the membrane form by proteolytic processing.
messages: Derives from the plasma membrane form by proteolytic cleavage and translocates to the nucleus. Homophilic binding of the C-terminal extracellular domain stimulates its proteolytic cleavage and release in the cytoplasmic. Is subjected to rapid degradation by the proteasome pathway (By similarity).
messages: EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
messages: Endoplasmic reticulum
messages: Expressed in the brain (at protein level).
messages: From 17 dpc to 18 dpc embryos, a very strong signal appeared and continued throughout the remaining prenatal days. The signal was strongest in the cerebral cortex (including the cingulate cortex, neocortex, and orbital and insular area), thalamus (anterior and intermediate thalamus), and weak in posterior thalamus and midbrain.
messages: Golgi apparatus
messages: Homodimer; disulfide-linked (Probable). Heterodimer with either TENM1 or TENM3. May also form heterodimer with TENM4 (By similarity). Interacts with ADGRL1 isoform 2.
messages: Induces gene transcription inhibition.
messages: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Mediates axon guidance and homophilic and heterophilic cell-cell adhesion. May function as a cellular signal transducer (By similarity). Acts as a ligand of the ADGRL1 receptor.
messages: PML body
messages: Postsynaptic cell membrane
messages: Synapse
messages: dendritic spine
messages: filopodium
messages: growth cone
messages: synaptosome

10116:P2ry13
gene id: 10116:P2ry13
uniprot id: A6JVK3
uniprot id: Q6GUG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Highest levels in spleen, liver brain and kidney. Lower but significant level are also detected in intestine, stomach, skeletal muscle, testis, heart and lung.
messages: Membrane
messages: Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.

10116:Plb1
gene id: 10116:Plb1
uniprot id: O54728
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.
messages: Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity) (By similarity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids (PubMed:9442065, PubMed:9442064, PubMed:11401559). Preferentially cleaves sn-2 ester bonds over sn-1 bonds (PubMed:9442064). Acts as a lipase toward glycerolipid substrates (PubMed:9442065, PubMed:9442064, PubMed:11401559). Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity (PubMed:9442065, PubMed:9442064, PubMed:11401559). May also hydrolyze long chain retinyl esters such as retinyl palmitate (By similarity). May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border (Probable).
messages: Expressed in the ileum mucosa, Paneth cells spermatocytes, spermatids and sperm (at protein level). Expressed in the ileum, jejunum, esophagus and testis.
messages: Repeat 2 contains the catalytic domain.
messages: Undergoes proteolytic cleavage in the ileum.
messages: Up-regulated by bile acids such as deoxycholate (PubMed:9442065, PubMed:9442064). Inhibited by diisopropyl fluorophosphate (PubMed:9442065, PubMed:9442064).

10116:Rab3c
gene id: 10116:Rab3c
uniprot id: A0A8L2Q7P7
uniprot id: A6I5M1
uniprot id: P62824
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Interacts with RIMS2, RPH3A and RPH3AL (By similarity). Interacts with RIMS1 (PubMed:9252191). Interacts with GDI2 and CHM; phosphorylation at Thr-86 disrupts these interactions (By similarity). Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (By similarity).
messages: Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM and RAB GDP dissociation inhibitor GDI2.
messages: Protein transport. Probably involved in vesicular traffic (By similarity).
messages: Protein transport. Probably involved in vesicular traffic.

10116:Serpina16
gene id: 10116:Serpina16
uniprot id: Q7TN19
names: Similarity
messages: Belongs to the serpin family.

10116:Tbx6
gene id: 10116:Tbx6
uniprot id: D3ZJK7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to also play an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity).

10116:Clxn
gene id: 10116:Clxn
uniprot id: A6JSS4
uniprot id: M0RCD9
names: Similarity
messages: Belongs to the recoverin family.

10116:Olr1330
gene id: 10116:Olr1330
uniprot id: A6J3N6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Cacnb4
gene id: 10116:Cacnb4
uniprot id: A0A8I6A7M3
uniprot id: A0A8I6ARA9
uniprot id: D4A055
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calcium channel beta subunit family.
messages: The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with FASLG (By similarity). Interacts with CBARP (By similarity).
messages: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

10116:Prickle1
gene id: 10116:Prickle1
uniprot id: A6K7T7
uniprot id: G3V8Z4
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

10116:Atp5mk
gene id: 10116:Atp5mk
uniprot id: A6JHP6
uniprot id: Q9JJW3
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL (By similarity). The ATP synthase complex/complex V exists as a monomeric and a dimeric supercomplex that helps shape mitochondrial cristae to optimize proton flow.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. ATP5MK is a minor subunit of the mitochondrial membrane ATP synthase required for dimerization of the ATP synthase complex and as such regulates ATP synthesis in the mitochondria.
messages: Mitochondrion membrane
messages: Ubiquitous. Highly expressed in skeletal and cardiac muscle. Moderately expressed in brain, thymus, stomach and testis. Lowest expression levels were detected in lung, liver, kidney, adrenal gland, spleen, small intestine and adipose tissue. In streptozotocin-induced diabetes, the insulin-sensitive tissues skeletal and cardiac muscle were down-regulated.

10116:Tesmin
gene id: 10116:Tesmin
uniprot id: Q5XHX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Cytoplasm
messages: May have a role in spermatogenesis.
messages: Nucleus

10116:Selenow
gene id: 10116:Selenow
uniprot id: P63301
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SelWTH family. Selenoprotein W subfamily.
messages: Cytoplasm
messages: Higher levels are seen in the muscle and brain while lower levels are seen in the spleen and testis. Not detected in liver, heart, kidney, intestinal mucosa, intestinal muscle, lung, plasma or erythrocytes (at protein level).
messages: In skeletal muscle, by dietary selenium.
messages: Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90.
messages: Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency.

10116:Cpn1
gene id: 10116:Cpn1
uniprot id: A6JHE4
uniprot id: Q9EQV8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Plasma. Expressed in liver.
messages: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
messages: Tetramer of two catalytic chains and two glycosylated inactive chains.
messages: extracellular space

10116:Prss35
gene id: 10116:Prss35
uniprot id: Q5R212
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Although related to peptidase S1 family, lacks the conserved active Ser residue in position 339 which is replaced by a Thr, suggesting that it has no protease activity.
messages: Belongs to the peptidase S1 family.
messages: Secreted

10116:Sarnp
gene id: 10116:Sarnp
uniprot id: Q498U4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity).
messages: Interacts with DDX39A. Interacts with FUS. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure involving ATP-dependent remodeling; in the complex interacts directly with DDX39B in a ATP-dependent manner which bridges it to ALYREF/THOC4 (By similarity).
messages: Nucleus
messages: Nucleus speckle

10116:Sod2
gene id: 10116:Sod2
uniprot id: A6KP26
uniprot id: P07895
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix
messages: Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
messages: Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.

10116:Crot
gene id: 10116:Crot
uniprot id: A6K232
uniprot id: F7F5D0
uniprot id: P11466
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate.
messages: Liver.
messages: Peroxisome

10116:Fer
gene id: 10116:Fer
uniprot id: A6JRA6
uniprot id: F1LPI8
uniprot id: P09760
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell junction
messages: Cell membrane
messages: Cell projection
messages: Cytoplasm
messages: Homotrimer. Interacts with IRS1, JAK1, NRP1, PIK3R1, PLEC and TMF1. Interacts with PPP1CA and regulates its phosphorylation at 'Thr-320'. Interacts with CTNND1, EGFR, FLT3, PECAM1, PDGFR and STAT3. Interacts (via SH2 domain) with CTTN. Interacts with HSP90; this stabilizes phosphorylated FER and protects FER against proteasomal degradation. Component of a complex that contains at least FER, CTTN and PTK2/FAK1 (By similarity). Interacts with ARHGDIA.
messages: Membrane
messages: Nucleus
messages: Polyubiquitinated; this leads to proteasomal degradation.
messages: The N-terminal region including the first coiled coil domain mediates interaction with phosphoinositide-containing membranes.
messages: The coiled coil domains mediate homooligomerization and are required for location at microtubules.
messages: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this clearly depends on cell type and stimulus (By similarity). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission.
messages: cell cortex
messages: cytoskeleton

10116:Cct6a
gene id: 10116:Cct6a
uniprot id: Q3MHS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm

10116:Or5w8b
gene id: 10116:Or5w8b
uniprot id: A0A8I6A3X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Orc1
gene id: 10116:Orc1
uniprot id: A6JYV4
uniprot id: Q80Z32
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity). Interacts with CDC6 and KAT7/HBO1 (By similarity). Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated (By similarity).
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).
messages: Nucleus
messages: Phosphorylated during mitosis.
messages: The BAH domain mediates binding to dimethylated histone H4 'Lys-20' (H4K20me2), which is enriched at replication origins.

10116:Zscan25
gene id: 10116:Zscan25
uniprot id: A6K1D9
names: Subcellular Location Annotation
messages: Nucleus

10116:Gbp5
gene id: 10116:Gbp5
uniprot id: B5DF73
uniprot id: F1M9F6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

10116:Sval2
gene id: 10116:Sval2
uniprot id: F7FPH3
uniprot id: Q99N74
names: Similarity
names: Subunit
messages: Belongs to the PIP family.
messages: Monomer. Interacts with AZGP1.

10116:Zng1a
gene id: 10116:Zng1a
uniprot id: A0A8I6A519
uniprot id: Q99MB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.
messages: Nucleus
messages: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1 to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1.

10116:Tbrg1
gene id: 10116:Tbrg1
uniprot id: A6KRK2
uniprot id: Q5PQK8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability (By similarity).
messages: Belongs to the TBRG1 family.
messages: Interacts with CDKN2A and MDM2.
messages: Nucleus
messages: Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation.

10116:Atp6v1a
gene id: 10116:Atp6v1a
uniprot id: A6IR15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Vesicle
messages: clathrin-coated vesicle membrane
messages: secretory vesicle

10116:Csrnp3
gene id: 10116:Csrnp3
uniprot id: A6HLX7
uniprot id: D4AE74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

10116:Or56a5
gene id: 10116:Or56a5
uniprot id: D4A7H3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Olr1063
gene id: 10116:Olr1063
uniprot id: A6K836
uniprot id: D3ZJQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tsc22d3
gene id: 10116:Tsc22d3
uniprot id: A0A8I5ZQF5
uniprot id: A6HLR6
uniprot id: Q9EQZ1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TSC-22/Dip/Bun family.
messages: Can form homodimers, however it is likely to function as a monomer (By similarity). Interacts with NFKB1 (By similarity). Interacts (via N-terminus) with JUN and FOS; these interactions inhibit the binding of active AP1 to its target DNA (By similarity). Interacts with MYOD1 (By similarity). Interacts with HDAC1; this interaction affects HDAC1 activity on MYOG promoter and thus inhibits MYOD1 transcriptional activity (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (By similarity). In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 (By similarity). In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities (By similarity). In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (By similarity).
messages: The leucine-zipper is involved in homodimerization.

10116:Olr1523
gene id: 10116:Olr1523
uniprot id: A0A8I5ZQJ0
uniprot id: A6HHW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Scnn1b
gene id: 10116:Scnn1b
uniprot id: A0A9K3Y6R5
uniprot id: B8QP48
uniprot id: P37090
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by WNK1, WNK2, WNK3 and WNK4.
messages: Apical cell membrane
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily.
messages: Cytoplasmic vesicle membrane
messages: Expressed in lung and epididymis (PubMed:30659401). In the caput region of the epididymis, expressed at the luminal and basolateral surfaces of the ducts and in the smooth muscle coat (PubMed:30659401). In the caudal region of the epididymis, expressed along the luminal border but not continuously, in the smooth muscle coat, in the interstitial muscle tissue and in sperm in the caudal lumen (PubMed:30659401).
messages: Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit (PubMed:9118951). An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties (By similarity). Interacts with NEDD4 (via WW domains) (PubMed:12654927, PubMed:11323714). Interacts with NEDD4L (via WW domains) (By similarity). Interacts with WWP1 (via WW domains) (By similarity). Interacts with WWP2 (via WW domains) (By similarity). Interacts with the full-length immature form of PCSK9 (pro-PCSK9) (By similarity). Interacts (N-glycosylated) with BPIFA1; the interaction is direct and inhibits the proteolytic processing of SCNN1A and SCNN1G and the activation of ENaC (By similarity).
messages: Membrane
messages: N-glycosylated (PubMed:11773057). N-glycosylation is required for interaction with BPIFA1 (By similarity).
messages: Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation.
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride (PubMed:9118951). Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.

10116:Phyhip
gene id: 10116:Phyhip
uniprot id: A6HTK5
uniprot id: Q568Z9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PHYHIP family.
messages: Interacts with PHYH and ADGRB1.
messages: Its interaction with PHYH suggests a role in the development of the central system.

10116:Or4f47
gene id: 10116:Or4f47
uniprot id: A0A8I6AMV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ankh
gene id: 10116:Ankh
uniprot id: P58366
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Cell membrane
messages: Transports adenosine triphosphate (ATP) and possibly other nucleoside triphosphates (NTPs) from cytosol to the extracellular space. Mainly regulates their levels locally in peripheral tissues while playing a minor systemic role. Prevents abnormal ectopic mineralization of the joints by regulating the extracellular levels of the calcification inhibitor inorganic pyrophosphate (PPi), which originates from the conversion of extracellular NTPs to NMPs and PPis by ENPP1. Regulates the release of the TCA cycle intermediates to the extracellular space, in particular citrate, succinate and malate. Extracellular citrate mostly present in bone tissue is required for osteogenic differentiation of mesenchymal stem cells, stabilization of hydroxyapatite structure and overall bone strength. The transport mechanism remains to be elucidated.

10116:Pacs2
gene id: 10116:Pacs2
uniprot id: D3ZJG4
names: Similarity
messages: Belongs to the PACS family.

10116:Inip
gene id: 10116:Inip
uniprot id: A6KDX4
uniprot id: D3Z914
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

10116:Olr1361
gene id: 10116:Olr1361
uniprot id: A6HCI9
uniprot id: P23266
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.
messages: Olfactory epithelium.

10116:Pde7b
gene id: 10116:Pde7b
uniprot id: A0A8I5ZWQ4
uniprot id: Q8VIE4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

10116:Xab2
gene id: 10116:Xab2
uniprot id: Q99PK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with RNA polymerase II, the TCR-specific proteins CKN1/CSA and ERCC6/CSB, and XPA. Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE. Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex. The IB complex does not contain PRPF19.
messages: Belongs to the crooked-neck family.
messages: Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing.
messages: Nucleus

10116:Arsg
gene id: 10116:Arsg
uniprot id: A6HKB4
uniprot id: Q32KJ9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 63-kDa precursor undergoes proteolytic processing in two steps, yielding two fragments in the first step (apparent molecular masses of 44 and 18 kDa) (By similarity). In the second step, the 44-kDa fragment is processed further to the 34- and 10-kDa chains. The 10-kDa chain is a cleavage product of the 44-kDa fragment but linked to the 18-kDa chain through a disulfide bridge (By similarity).
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Displays arylsulfatase activity at acidic pH towards the artificial substrate p-nitrocatechol sulfate (By similarity). Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin (By similarity).
messages: Lysosome
messages: N-glycosylated with both high mannose and complex type sugars.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

10116:Fundc2b
gene id: 10116:Fundc2b
uniprot id: Q6AYM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

10116:Tdrp
gene id: 10116:Tdrp
uniprot id: Q498E2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TDRP family.
messages: Contributes to normal sperm motility, but not essential for male fertility.
messages: Cytoplasm
messages: In testis: weakly expressed in newborns, increases remarkably at 3 weeks postpartum, and peaks at 2 months postpartum (at protein level).
messages: Interacts with PRM2.
messages: Nucleus
messages: Predominantly expressed in testis.

10116:Myh3
gene id: 10116:Myh3
uniprot id: P12847
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-3 (MYO3).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: myofibril

10116:Zc3h14
gene id: 10116:Zc3h14
uniprot id: A0A0G2K596
uniprot id: A0A8I6A1Y3
uniprot id: Q7TMD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZC3H14 family.
messages: Interacts with HOOK2. Interacts with ZFC3H1 in a RNase-sensitive manner.
messages: Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.
messages: Nucleus speckle

10116:Slc7a6os
gene id: 10116:Slc7a6os
uniprot id: A6IYW4
uniprot id: G3V8N8
uniprot id: Q8CIV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWR1/SLC7A6OS family.
messages: Cytoplasm
messages: Directs RNA polymerase II nuclear import.
messages: Nucleus

10116:Mcfd2
gene id: 10116:Mcfd2
uniprot id: Q8K5B3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus
messages: Interacts in a calcium-dependent manner with LMAN1.
messages: The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.

10116:Nanos3
gene id: 10116:Nanos3
uniprot id: A6IYA5
uniprot id: D4A138
names: Similarity
messages: Belongs to the nanos family.

10116:Pax8
gene id: 10116:Pax8
uniprot id: A6JSY7
uniprot id: P51974
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with WWTR1.
messages: Nucleus
messages: Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development (By similarity).

10116:Paqr8
gene id: 10116:Paqr8
uniprot id: A0A8I5XVB9
uniprot id: Q6AY03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

10116:Gabrr3
gene id: 10116:Gabrr3
uniprot id: A6IQJ1
uniprot id: P50573
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR3 sub-subfamily.
messages: Cell membrane
messages: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Forms a ternary complex with SQSTM1 and PRKCZ.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Retina.
messages: Synaptic cell membrane

10116:Or4c109
gene id: 10116:Or4c109
uniprot id: A0A0G2K3S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Brf2
gene id: 10116:Brf2
uniprot id: Q4V8D6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIB family.
messages: Component of TFIIIB complexes. The TFIIIB complex has two activities, alpha and beta. The TFIIIB-alpha activity complex is composed of TBP, BDP1, and a complex containing both BRF2 and at least four stably associated proteins; this complex inhibits the transcription by pol III via its phosphorylation by CK2; YY1 facilitates the TFIIIB-alpha complex formation. Interacts with TBP; this interaction promotes recruitment of BRF2 to TATA box-containing promoters. Interacts with TBP and the BURE sequence (GC-rich sequence downstream from the TATA box) to form a strong ternary complex which is joined by BDP1; this ternary complex stimulates pol III transcription. Forms a trimeric complex composed of TBP, BRF2 and mini-SNAPc complex (SNAP43, SNAP50, and the N-terminal third of SNAP190) on the promoter. Assembly of the TBP-BRF2 complex is stimulated by SNAP190. Interacts with MAF1 and SNAPC4.
messages: General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress.
messages: In response to oxidative stress, Cys-358 is reversibly oxidized to cysteine sulfenic acid. Oxidation of Cys-358 impairs formation of a ternary complex with TBP and DNA and down-regulates expression of target genes in response to oxidative stress.
messages: Nucleus

10116:Leg1
gene id: 10116:Leg1
uniprot id: F1M171
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEG1 family.
messages: Secreted

10116:Svip
gene id: 10116:Svip
uniprot id: P0C0A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SVIP family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Interacts with VCP.
messages: Membrane
messages: Overexpression causes the formation of large vacuoles that seemed to be derived from the endoplasmic reticulum.
messages: Smooth endoplasmic reticulum membrane
messages: Ubiquitous.

10116:Arl6ip5
gene id: 10116:Arl6ip5
uniprot id: A6IBF8
uniprot id: Q9ES40
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PRA1 family.
messages: By methyl-beta-cyclodextrin.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Homodimer. Heterodimer with ARL6IP1 (By similarity). Forms multimers (PubMed:11242046). Interacts with ARL6 (By similarity). Interacts with prenylated RAB1A and RAB3A (PubMed:11096102). Interacts with SLC1A1/EAAC1 (PubMed:11242046). Interacts with RTN2 (via first transmembrane domain) (PubMed:19720795). Does not interact with VAMP1, VAMP2 or VAMP3 (PubMed:11096102).
messages: Membrane
messages: Regulates intracellular concentrations of taurine and glutamate (Ref.5). Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner (PubMed:11242046). Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum (PubMed:19720795).
messages: Ubiquitous (PubMed:11096102). Most abundant in heart and brain (PubMed:11096102). In the embryonic brain cortex, expressed in neurons and astrocytes (PubMed:19720795).
messages: cytoskeleton

10116:Hpgd
gene id: 10116:Hpgd
uniprot id: A6KIY1
uniprot id: O08699
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (PubMed:9099857) (By similarity). Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation (By similarity).
messages: Cytoplasm
messages: Homodimer.

10116:Nkiras1
gene id: 10116:Nkiras1
uniprot id: B5DFJ1
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

10116:Arhgap20
gene id: 10116:Arhgap20
uniprot id: Q6REY9
names: Developmental Stage
names: Function
names: Tissue Specificity
messages: Found to be expressed in developing spermatocytes, but not in terminally differentiated spermatozoa.
messages: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
messages: Highest expression is found in testis. Ubiquitously expressed in extragonadal tissues.

10116:Stard5
gene id: 10116:Stard5
uniprot id: A6JCM3
uniprot id: D3ZN38
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

10116:Gkn2
gene id: 10116:Gkn2
uniprot id: Q29TV8
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer with TFF1; disulfide linked. Interacts with TFF2 (By similarity).
messages: Secreted

10116:Gldn
gene id: 10116:Gldn
uniprot id: Q80WL1
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Detected in Schwann cells (at protein level).
messages: Expression increases in myelinating Schwann cells during the initial period of active myelination.
messages: Homotrimer (via collagen-like domains) (PubMed:17485493) (Probable). Interacts with NRCAM (PubMed:16039564, PubMed:22009740). Interacts with NFASC/neurofascin (PubMed:16039564, PubMed:17485493, PubMed:22009740). Interaction with glial NRCAM enhances interaction with axonal NFASC. Interacts with MYOC (By similarity).
messages: Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC (PubMed:16039564). Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier (By similarity).
messages: N-glycosylated.
messages: Proteolytic proccessing by a furin-like protease causes shedding of the ectodomain (PubMed:17485493). Further cleavage by BMP1 releases the olfactomedin-like domain.
messages: Secreted
messages: The olfactomedin-like domain mediates NFASC/neurofascin and NRCAM binding.
messages: axon
messages: extracellular matrix

10116:Iah1
gene id: 10116:Iah1
uniprot id: B5DER3
uniprot id: Q711G3
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

10116:Vom2r27
gene id: 10116:Vom2r27
uniprot id: O35269
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:LOC306766
gene id: 10116:LOC306766
uniprot id: A6KAZ0
uniprot id: Q5U2R6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth (By similarity).
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

10116:Ly49i7
gene id: 10116:Ly49i7
uniprot id: Q5MPP5
names: Subcellular Location Annotation
messages: Membrane

10116:Or4c117b
gene id: 10116:Or4c117b
uniprot id: A0A8I6GB91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Treh
gene id: 10116:Treh
uniprot id: A6J407
uniprot id: G3V7Q9
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

10116:Dtwd2
gene id: 10116:Dtwd2
uniprot id: A6IWZ4
names: Similarity
messages: Belongs to the TDD superfamily. DTWD2 family.

10116:Stk16
gene id: 10116:Stk16
uniprot id: P57760
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: By TGF-beta.
messages: Expressed in heart, liver, brain, spleen, lung, skeletal muscle, kidney and testis.
messages: Mainly autophosphorylated on serine/threonine residues. Also autophosphorylated on Tyr-198 (By similarity).
messages: Membrane
messages: Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates (By similarity). May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.
messages: Monomer. Interacts with DRG1 (via its N-terminal); the interaction phosphorylates DRG1.
messages: perinuclear region

10116:Dzip1l
gene id: 10116:Dzip1l
uniprot id: A0A8L2UJI0
uniprot id: A6I2E2
uniprot id: Q5XIA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: Interacts with SEPTIN2.
messages: Involved in primary cilium formation. Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane.
messages: centriole
messages: cilium basal body

10116:Chpf
gene id: 10116:Chpf
uniprot id: F7F860
uniprot id: Q5XIQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

10116:Eya2
gene id: 10116:Eya2
uniprot id: Q6UN47
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

10116:Nck2
gene id: 10116:Nck2
uniprot id: A6INR5
uniprot id: D4A3M8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

10116:Gnas
gene id: 10116:Gnas
uniprot id: A0A8I6A4D8
uniprot id: B0BMW4
uniprot id: B4F771
uniprot id: P63095
uniprot id: Q792G6
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-alpha family. G(s) subfamily.
messages: Belongs to the NESP55 family.
messages: Binds keratan sulfate chains.
messages: Cell membrane
messages: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.
messages: Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site (By similarity). Interacts with CRY1; the interaction may block GPCR-mediated regulation of cAMP concentrations. Interacts with ADCY6 and stimulates its adenylyl cyclase activity (By similarity). Interacts with ADCY2 and ADCY5 (By similarity). Stimulates the ADCY5 adenylyl cyclase activity (By similarity). Interaction with SASH1 (By similarity). Interacts with GASL2L2 (By similarity).
messages: Isoform Gnas-3 is abundant in brain with intermediate levels in skeletal muscle and very low levels in other tissues.
messages: May be proteolytically processed to give rise to a number of active peptides.
messages: Secreted
messages: Shares no sequence similarity with other isoforms due to a novel first exon containing the entire reading frame spliced to shared exon 2 so that exons 2-13 make up the 3'-UTR.
messages: The GNAS locus is imprinted in a complex manner, giving rise to distinct paternally, maternally and biallelically expressed proteins. The XLas isoforms are paternally derived, the Gnas isoforms are biallelically derived and the Nesp55 isoforms are maternally derived.
messages: This protein is produced by a bicistronic gene which also produces the ALEX protein from an overlapping reading frame.
messages: synaptic vesicle

10116:Prss39
gene id: 10116:Prss39
uniprot id: Q6AXZ6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: May play an important role in the sperm/egg interaction; released during the acrosome reaction.
messages: Secreted
messages: There appears to be no human ortholog of this protein.
messages: acrosome

10116:Cxcl16
gene id: 10116:Cxcl16
uniprot id: A0A6M4C4P9
uniprot id: Q6AXU5
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: By interleukin-18 and the induction is strongly mediated by an activator protein-1-dependent pathway.
messages: Glycosylated.
messages: Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity).
messages: Membrane

10116:Olr1122
gene id: 10116:Olr1122
uniprot id: A6JNF7
uniprot id: D3ZM88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Shmt2
gene id: 10116:Shmt2
uniprot id: Q5U3Z7
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

10116:Casp7
gene id: 10116:Casp7
uniprot id: A0A8I5ZQU7
uniprot id: A6JI19
uniprot id: A6JI22
uniprot id: Q6IRF9
names: Similarity
messages: Belongs to the peptidase C14A family.

10116:Hsph1
gene id: 10116:Hsph1
uniprot id: A6K161
uniprot id: Q66HA8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with HSPA8/HSC70. Interacts with HSPA1A (via NBD) and HSPA1B (via NBD).
messages: Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.

10116:Pex12
gene id: 10116:Pex12
uniprot id: A6HHG9
uniprot id: O88177
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity).
messages: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12. Interacts with PEX19 via its cytoplasmic domain.
messages: Membrane
messages: Peroxisome membrane
messages: The RING-type zinc-finger is degenerated and only coordinates one zinc ions, preventing E3 ubiquitin-protein ligase activity.
messages: The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore. The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex.

10116:Pm20d2
gene id: 10116:Pm20d2
uniprot id: D4AAB5
names: Function
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus.

10116:Il1rapl1
gene id: 10116:Il1rapl1
uniprot id: A0A096MJW6
uniprot id: A6IPX4
uniprot id: P59824
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the interleukin-1 receptor family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts (calcium-independent) with NCS1/FREQ (By similarity). Interacts (via the first immunoglobilin domain) with PTPRD (via the second immunoglobilin domain); this interaction is PTPRD-splicing-dependent and induces pre- and post-synaptic differentiation of neurons and is required for IL1RAPL1-mediated synapse formation (By similarity).
messages: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel (PubMed:17502602). May activate the MAP kinase JNK (By similarity). Plays a role in neurite outgrowth (PubMed:18801879). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).
messages: The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
messages: axon
messages: dendrite

10116:Fam193a
gene id: 10116:Fam193a
uniprot id: D3ZIG8
names: Similarity
messages: Belongs to the FAM193 family.

10116:Asf1b
gene id: 10116:Asf1b
uniprot id: A0A8I5ZUP3
uniprot id: A6IYC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

10116:Nipsnap3b
gene id: 10116:Nipsnap3b
uniprot id: Q5M949
names: Similarity
messages: Belongs to the NipSnap family.

10116:Pik3r2
gene id: 10116:Pik3r2
uniprot id: A6KA00
uniprot id: F7F9A3
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

10116:Fzd1
gene id: 10116:Fzd1
uniprot id: A6K268
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:H1f1
gene id: 10116:H1f1
uniprot id: D4A3K5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Citrullination at Arg-56 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
messages: H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.
messages: H1 histones bind to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. H1 histones are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling (By similarity).
messages: Interacts with DFFB.
messages: Nucleus
messages: The C-terminal domain is required for high-affinity binding to chromatin.

10116:Syngr4
gene id: 10116:Syngr4
uniprot id: Q4KLY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

10116:Ppp1r7
gene id: 10116:Ppp1r7
uniprot id: A6JQY6
uniprot id: Q5HZV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDS22 family.
messages: Interacts with PPP1CA, PPP1CB and PPP1CC/PPP1G.
messages: Nucleus
messages: Regulatory subunit of protein phosphatase 1.

10116:Mcoln2
gene id: 10116:Mcoln2
uniprot id: Q499S1
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

10116:Sgpl1
gene id: 10116:Sgpl1
uniprot id: Q8CHN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.
messages: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity).
messages: Endoplasmic reticulum membrane
messages: Homodimer.

10116:Or5g29
gene id: 10116:Or5g29
uniprot id: A6HMU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Fam9b
gene id: 10116:Fam9b
uniprot id: A0A8I6AT34
names: Similarity
messages: Belongs to the XLR/SYCP3 family.

10116:Dhtkd1
gene id: 10116:Dhtkd1
uniprot id: Q4KLP0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2-oxoadipate dehydrogenase (E1a) component of the 2-oxoadipate dehydrogenase complex (OADHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC. Catalyzes the irreversible decarboxylation of 2-oxoadipate via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST). Can catalyze the decarboxylation of 2-oxoglutarate in vitro, but at a much lower rate than 2-oxoadipate. Responsible for the last step of L-lysine, L-hydroxylysine and L-tryptophan catabolism with the common product being 2-oxoadipate.
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: Mitochondrion
messages: The 2-oxoadipate dehydrogenase complex is composed of OADH (2-oxoadipate dehydrogenase; E1a), DLST (dihydrolipoamide succinyltransferase; E2) and DLD (dihydrolipoamide dehydrogenase; E3). E1a functional unit is a dimer.
messages: The mitochondrial 2-oxoglutarate and 2-oxoadipate dehydrogenase complexes (OGDHC and OADHC, respectively) share their E2 (DLST) and E3 (dihydrolipoyl dehydrogenase or DLD) components, but the E1 component is specific to each complex (E1o and E1a, respectively).

10116:Sorbs2
gene id: 10116:Sorbs2
uniprot id: O35413
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 (By similarity). May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (By similarity). Isoform 2 increases water and sodium absorption in the intestine and gall-bladder.
messages: Apical cell membrane
messages: Expressed in brain; found in synapses in cerebellum.
messages: Interacts with ABL1/c-Abl, ABL2/v-Abl/Arg, ACTN, CBL and PALLD (By similarity). Interacts with ABL, CBL, DNM1, DNM2, FLOT1, AFDN, PTK2B/PYK2, SAPAP, SPTAN1, SYNJ1, SYNJ2, VCL/vinculin and WASF. Interacts with PTPN12 and WASF1 via its SH3 domains; this interaction may mediate the partial PTPN12 and WASF1 translocation to focal adhesion sites.
messages: The first 2 SH3 domains are required for WASF1-binding. All 3 SH3 domains can bind independently to PTPN12.
messages: Ubiquitinated by CBL.
messages: focal adhesion
messages: lamellipodium
messages: perinuclear region

10116:Slc9c2
gene id: 10116:Slc9c2
uniprot id: A0A8I6G3U6
names: Subcellular Location Annotation
messages: Cell membrane

10116:Gpt
gene id: 10116:Gpt
uniprot id: A6HSC5
uniprot id: P25409
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: By glucocorticoids.
messages: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity).
messages: Cytoplasm
messages: Homodimer.
messages: Liver, heart, skeletal muscle, etc.

10116:Tmem39a
gene id: 10116:Tmem39a
uniprot id: A6IR58
uniprot id: Q5U2V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM39 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with SACM1L, SEC23A and SEC24A.
messages: Membrane
messages: Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns(4)P) pools (By similarity). Modulates (PtdIns(4)P) levels by regulating the ER-to-Golgi trafficking of the phosphatidylinositide phosphatase SACM1L (By similarity).

10116:Strn3
gene id: 10116:Strn3
uniprot id: A0A8I5ZUH2
uniprot id: A0A8I6AGH7
uniprot id: E9PT82
uniprot id: P58405
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat striatin family.
messages: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (By similarity).
messages: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.
messages: Cytoplasm
messages: Interacts with protein phosphatase 2A (PP2A). Interacts with CDC42BPB.
messages: Membrane

10116:Rhox12
gene id: 10116:Rhox12
uniprot id: A6JMJ3
uniprot id: F7F8E5
names: Subcellular Location Annotation
messages: Nucleus

10116:Stx7
gene id: 10116:Stx7
uniprot id: A6JUL4
uniprot id: O70257
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the syntaxin family.
messages: Detected in all tissues tested. Highest expression is found in kidney followed by lung, spleen, heart and brain. Lower expression, in skeletal muscle, liver and testis.
messages: Early endosome membrane
messages: Interacts with VPS11, VPS16 and VPS18. Interacts with VPS33A (By similarity). Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes. Interacts with TPC1 (By similarity).
messages: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity).
messages: Membrane

10116:Pdxk
gene id: 10116:Pdxk
uniprot id: O35331
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity is increased in the presence of K(+)or Na(+).
messages: Belongs to the pyridoxine kinase family.
messages: Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (By similarity). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions (By similarity).
messages: Homodimer.
messages: cytosol

10116:Pag1
gene id: 10116:Pag1
uniprot id: Q9JM80
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: In contrast to the human ortholog, does not seem to interact with FYN.
messages: Interacts with NHERF1/EBP50. In resting T-cells, part of a PAG1-NHERF1-MSN complex which is disrupted upon TCR activation (By similarity). When phosphorylated, interacts with CSK. Identified in a complex with LYN and STAT3 (By similarity). Interacts with LYN.
messages: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
messages: Palmitoylated.
messages: Phosphorylated by FYN on Tyr-314 in resting T-cells; which promotes interaction with CSK. Dephosphorylated by PTPRC/CD45 upon TCR activation; which leads to CSK dissociation. May also be dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation. Phosphorylated by LYN in response to EPO.
messages: Ubiquitously expressed, with highest levels in developing brain, lung, thymus, spleen and testis. Present in mast cells.

10116:Pdlim7
gene id: 10116:Pdlim7
uniprot id: Q9Z1Z9
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Anchored to cell periphery via its N-terminal PDZ domain.
messages: At 14 dpc expressed in mesenchymal tissue surrounding the cartilaginous anlage of immature bones, and in the future joint spaces. As endochondral ossification progresses, and the hypertrophic cartilage zone is replaced by mineralized bone, expression appears in the mineralizing portion of the bone. Expressed in mesoderm derived bones of the skull base and neural crest-derived endochondral bones such as the proximal mandible.
messages: Binds via its LIM zinc-binding 3 domain (LIM 3) domain to endocytic codes of INSR, but not with those of IGF1R, LDLR, TFRC, or EGFR. Interacts with various PKC isoforms through the LIM zinc-binding domains. Binds to RET in a phosphorylation-independent manner via its LIM zinc-binding 2 domain (LIM 2). Probably part of a complex with SHC and the RET dimer. Interacts with TPM2, TBX4 and TBX5 (By similarity). Interacts (via LIM domains) with SIPA1L1.
messages: Cytoplasm
messages: Expressed in kidney, heart, brain, lung, and skeletal muscle. Overexpression results in the synthesis of an unidentified soluble factor which acts on cells in the osteoblast lineage causing them to differentiate and secrete BMP-2.
messages: Induced by glucocorticoid or BMP6.
messages: May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway.
messages: The LIM zinc-binding 2 (LIM 2) interacts with TBX4.
messages: The LIM zinc-binding 3 (LIM 3) domain provides the structural basis for recognition of tyrosine-containing tight turn structures. This domain is necessary and sufficient for interaction with TBX5 (By similarity).
messages: cytoskeleton

10116:Nanog
gene id: 10116:Nanog
uniprot id: A6ILF7
uniprot id: D3ZS29
names: Subcellular Location Annotation
messages: Nucleus

10116:Gskip
gene id: 10116:Gskip
uniprot id: A0A0H2UHD3
uniprot id: A6KBD3
uniprot id: Q5PPI3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity). May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (By similarity).
messages: Belongs to the GSKIP family.
messages: Cytoplasm
messages: Forms a complex composed of PRKAR2A or PRKAR2B, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation of GSK3B leading to GSK3B inactivation; recruits DNM1L through GSK3B for PKA-mediated phosphorylation of DNM1L; promotes beta-catenin degradation through GSK3B-induced phosphorylation of beta-catenin; stabilizes beta-catenin and enhances Wnt-induced signaling through PKA-induced phosphorylation of beta-catenin (PubMed:20007971). Interacts with GSK3B; induces GSK3B-mediated phosphorylation of GSKIP and inhibits GSK3B kinase activity (By similarity).
messages: Nucleus
messages: Phosphorylated by GSK3B.

10116:Rps12
gene id: 10116:Rps12
uniprot id: Q6PDW1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

10116:Galc
gene id: 10116:Galc
uniprot id: A0A0G2QC23
names: Similarity
messages: Belongs to the glycosyl hydrolase 59 family.

10116:Tubgcp5
gene id: 10116:Tubgcp5
uniprot id: A6KD27
uniprot id: D4A2A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

10116:Nxt2
gene id: 10116:Nxt2
uniprot id: A6KG69
uniprot id: B2GV77
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with NXF1, NXF2, NXF3 and NXF5.
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus
messages: Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export (By similarity).

10116:Sfxn3
gene id: 10116:Sfxn3
uniprot id: Q9JHY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors.
messages: Mitochondrion membrane

10116:Supt4h1
gene id: 10116:Supt4h1
uniprot id: B5DEM7
uniprot id: F7F5Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

10116:Ypel5
gene id: 10116:Ypel5
uniprot id: A6HA10
uniprot id: D4A4Q3
names: Similarity
messages: Belongs to the yippee family.

10116:Lrrtm3
gene id: 10116:Lrrtm3
uniprot id: D3ZAL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRTM family.
messages: Cell membrane
messages: May play a role in the development and maintenance of the nervous system (By similarity). Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation.
messages: Postsynaptic cell membrane

10116:Dusp29
gene id: 10116:Dusp29
uniprot id: A6KKS6
uniprot id: P0C595
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Cytoplasm
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of intracellular signaling cascades. In skeletal muscle regulates systemic glucose homeostasis by activating, AMPK, an energy sensor protein kinase. Affects MAP kinase signaling though modulation of the MAPK1/2 cascade in skeletal muscle promoting muscle cell differentiation, development and atrophy (By similarity).
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.
messages: Homodimer (By similarity). Interacts with PRKAA2 (By similarity).
messages: Nucleus

10116:Mzb1
gene id: 10116:Mzb1
uniprot id: Q561R0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance (By similarity).
messages: Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion, and integrin activation.
messages: Belongs to the MZB1 family.
messages: Endoplasmic reticulum lumen
messages: Forms an interchain disulfide bond with IgM monomers.
messages: Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner.
messages: Secreted

10116:Vom1r90
gene id: 10116:Vom1r90
uniprot id: Q5J3F6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in 1-4% of neurons of the vomeronasal organ. Only one pheromone receptor gene may be expressed in a particular neuron. Not expressed in the main olfactory epithelium.
messages: Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior.

10116:Oscp1
gene id: 10116:Oscp1
uniprot id: Q4QQS3
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basal cell membrane
messages: May be involved in drug clearance in the placenta.
messages: Predominantly expressed in testis.

10116:Pde8b
gene id: 10116:Pde8b
uniprot id: A0A8I5ZTX5
uniprot id: A0A8I6AJW4
uniprot id: Q76KC5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

10116:RT1-M6-1
gene id: 10116:RT1-M6-1
uniprot id: Q6MFY2
names: Subcellular Location Annotation
messages: Membrane

10116:Cdh12
gene id: 10116:Cdh12
uniprot id: F1M1A2
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

10116:Aass
gene id: 10116:Aass
uniprot id: A2VCW9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bifunctional enzyme that catalyzes the first two steps in lysine degradation.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the saccharopine dehydrogenase family.
messages: In the N-terminal section; belongs to the AlaDH/PNT family.
messages: Mitochondrion
messages: The N-terminal and the C-terminal domains contain respectively the lysine ketoglutarate reductase and saccharopine dehydrogenase activity.

10116:Krt25
gene id: 10116:Krt25
uniprot id: Q6IFX0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (By similarity).
messages: Heterodimer of a type I and a type II keratin. Heterodimer with type II keratin KRT5 leading to the formation of keratin intermediate filament (KIF) network. Interacts with KRT6A to form filaments.
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

10116:Hormad1
gene id: 10116:Hormad1
uniprot id: D3ZWE7
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Interacts with HORMAD2. Interacts with IHO1.
messages: Nucleus
messages: Phosphorylated at Ser-375 in a SPO11-dependent manner.
messages: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.

10116:Sirt4
gene id: 10116:Sirt4
uniprot id: A6J1T8
uniprot id: G3V641
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.
messages: Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.
messages: Mitochondrion matrix

10116:Dctd
gene id: 10116:Dctd
uniprot id: A0A0A0MXX3
uniprot id: A6JPJ8
uniprot id: D3ZXS5
uniprot id: Q5M9G0
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Homohexamer.
messages: Supplies the nucleotide substrate for thymidylate synthetase.

10116:Fmo1
gene id: 10116:Fmo1
uniprot id: A6IDA3
uniprot id: P36365
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FMO family.
messages: Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics (PubMed:8504165). Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes (By similarity). In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine (PubMed:8504165).
messages: Endoplasmic reticulum membrane
messages: Expressed in liver, lung and kidney and to a lesser extent in the heart and brain.
messages: Membrane

10116:Maea
gene id: 10116:Maea
uniprot id: Q5RKJ1
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated as component of the CTLH E3 ubiquitin-protein ligase complex (in vitro).
messages: Cell membrane
messages: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (By similarity).
messages: Cytoplasm
messages: Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Interacts with F-actin.
messages: Nucleus matrix
messages: The expected RING-type zinc finger domain is highly divergent and most of the expected Cys residues are not conserved. Still, the protein is required for CTLH complex E3 ubiquitin-protein transferase activity. In addition, the conserved Cys-314 in this highly divergent region is required for ubiquitination by the yeast GID complex, suggesting a direct role in catalyzing ubiquitination.
messages: cytoskeleton
messages: nucleoplasm

10116:Fut10
gene id: 10116:Fut10
uniprot id: M0R8J2
uniprot id: Q5F2L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Golgi stack membrane
messages: Membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. Postulated to generate core alpha(1->3)-fucose epitope within the chitobiose unit of biantennary N-glycans, providing for a recognition signal to reorient aberrantly folded glycoproteins for degradation (By similarity). Involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development (By similarity).

10116:Tatdn2
gene id: 10116:Tatdn2
uniprot id: A6IBT8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

10116:Il11ra1
gene id: 10116:Il11ra1
uniprot id: A0A8I6ARG9
uniprot id: A6IIX5
uniprot id: Q99MF4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A short soluble form is also released from the membrane by proteolysis. The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing. mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3.
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.
messages: Membrane
messages: On IL11 binding, forms a multimer complex with IL6ST/gp130.
messages: Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.
messages: Secreted
messages: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.

10116:Cops3
gene id: 10116:Cops3
uniprot id: Q68FW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN3 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo (By similarity).
messages: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (By similarity). In the complex, it probably interacts directly with COPS1, COPS4, COPS8 and COPS9 (By similarity). Interacts with CK2 and PKD (By similarity). Interacts with the translation initiation factor EIF3S6 and IKBKG (By similarity). Interacts with ERCC6 (By similarity).
messages: Cytoplasm
messages: Nucleus

10116:Uba5
gene id: 10116:Uba5
uniprot id: A6I2L1
uniprot id: Q5M7A4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Cytoplasm
messages: E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP. Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer. Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding. Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (By similarity). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity).
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Homodimer; homodimerization is required for UFM1 activation. Interacts (via UIS motif) with UFM1; binds UFM1 via a trans-binding mechanism in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer. Interacts (via UIS motif) with GABARAPL2 and, with lower affinity, with GABARAP and GABARAPL1. Interacts (via C-terminus) with UFC1.
messages: Nucleus
messages: The UFM1-interacting sequence (UIS) motif mediates interaction with both UFM1 and LC3/GABARAP proteins (GABARAP, GABARAPL1 and GABARAPL2).

10116:Clca5
gene id: 10116:Clca5
uniprot id: Q75ZI5
names: Similarity
messages: Belongs to the CLCR family.

10116:Pramel6
gene id: 10116:Pramel6
uniprot id: A6HMZ3
uniprot id: D3ZD67
names: Similarity
messages: Belongs to the PRAME family.

10116:Itgb8
gene id: 10116:Itgb8
uniprot id: A0A0G2JVU1
uniprot id: A6KDM9
uniprot id: D3ZP06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

10116:Usp45
gene id: 10116:Usp45
uniprot id: A0A0G2K4S7
uniprot id: A0A8I6AG99
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

10116:Olr889
gene id: 10116:Olr889
uniprot id: D3ZHW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ivl
gene id: 10116:Ivl
uniprot id: P48998
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the involucrin family.
messages: Cytoplasm
messages: Directly or indirectly cross-linked to cornifelin (CNFN).
messages: Keratinocytes of epidermis and other stratified squamous epithelia.
messages: Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
messages: Substrate of transglutaminase. Specific glutamines or lysines are cross-linked to keratins, desmoplakin and to inter involucrin molecules.

10116:Cdc42ep1
gene id: 10116:Cdc42ep1
uniprot id: A1A5P0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system
messages: Interacts with RHOQ and CDC42, in a GTP-dependent manner.
messages: Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts (By similarity).
messages: The CRIB domain mediates interaction with CDC42.
messages: cytoskeleton

10116:Scyl1
gene id: 10116:Scyl1
uniprot id: Q5M9F8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Homooligomer. Interacts with GORAB. Interacts with COPA, COPB1 and COPB2. Interacts with AP2B1 (By similarity).
messages: Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro.
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: centrosome
messages: cis-Golgi network

10116:Gsto1
gene id: 10116:Gsto1
uniprot id: A6JHR8
uniprot id: F7F9Z0
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

10116:Slc25a21
gene id: 10116:Slc25a21
uniprot id: A6HBP1
uniprot id: Q99JD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle.
messages: Widely expressed.

10116:Mrps33
gene id: 10116:Mrps33
uniprot id: F7EUA0
uniprot id: Q0ZFS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

10116:Zmynd19
gene id: 10116:Zmynd19
uniprot id: Q7TSV3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with GPR24/MCH-R1.
messages: May be involved as a regulatory molecule in GPR24/MCH-R1 signaling.

10116:Git1
gene id: 10116:Git1
uniprot id: Q9Z272
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Forms homodimers and possibly oligomers (PubMed:12473661, PubMed:19136011). May form heterooligomers with GIT2 (Probable). Interacts with G protein-coupled receptor kinases, including GRK2, GRK3, GRK5 and GRK6 (PubMed:9826657). Interacts with PPFIA1, PPFIA2 and PPFIA4 (PubMed:12473661, PubMed:12629171). Interacts with GRIP1 and forms a ternary complex with PPFIA1 and GRIP1 (PubMed:12473661, PubMed:12629171). Directly interacts with ARHGEF7/beta-PIX, forming in vitro a heptameric complex made of a GIT1 dimer and an ARHGEF7 trimer (PubMed:10938112, PubMed:12473661, PubMed:12629171, PubMed:17310244, PubMed:19136011). Directly interacts with PXN/paxillin; this interaction is enhanced in the presence of ARHGEF7 (PubMed:10938112, PubMed:12153727, PubMed:12473661, PubMed:12629171). Directly interacts (via C-terminus) with TGFB1I1/Hic-5 (via LD motif 3) (PubMed:12153727). Directly interacts with PTK2/FAK1 (PubMed:10938112, PubMed:12473661, PubMed:12629171). May interact with PTK2B/PYK2; this interaction may be indirect (PubMed:12629171). Interacts with AMPA receptors GRIA2/3 (PubMed:12629171). Directly interacts with protein Piccolo/PCLO (PubMed:12473661). Forms a complex with Ephrin-B1/EFNB1 and NCK2/GRB4 (via SH2); this interaction is important for spine morphogenesis and synapse formation. Interaction with NCK2 is transient and depends upon GIT1 phosphorylation at Tyr-392 (PubMed:17310244). Interacts with GRIN3A/GluN3A (via C-terminus); this interaction competes with GIT1 interaction with ARHGEF7 and limits synaptic localization of GIT1 (PubMed:24297929). Interacts with IKBKG/NEMO in resting bone mesenchymal stem cells, as well as in TNF-stimulated cells; this interaction may increase IKBKG affinity for 'Lys-63'-linked polyubiquitin chains (By similarity). Interacts with GABA(A) receptors, including GABRB3 and GABRG2 (PubMed:25284783). Interacts with SCRIB (By similarity). Interacts (via N- and C-terminus) with ENTR1/SDCCAG3 (via N-terminus); this interaction is direct. …
messages: GTPase-activating protein for ADP ribosylation factor family members, including ARF1 (PubMed:9826657). Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (PubMed:9826657). Through PAK1 activation, positively regulates microtubule nucleation during interphase. Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (By similarity). May promote cell motility both by regulating focal complex dynamics and by the activation of RAC1 (PubMed:10938112). May act as scaffold for MAPK1/3 signal transduction, recruiting MAPK1/3 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193, PubMed:17310244, PubMed:24297929, PubMed:25009255). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12473661). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (PubMed:12473661). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (PubMed:12629171). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) recepto…
messages: In the brain cortex and in the hippocampus, continuously expressed from P0 to adult age (at protein level).
messages: Phosphorylated on tyrosine residues by PTK2/FAK1 and SRC in growing fibroblasts (PubMed:10938112). Phosphorylation at Tyr-392 is induced by activation of Ephrin-B1/EFNB1 and catalyzed by SRC family kinases. It is required for the interaction with NCK2 and for GIT1 recruitment to synapses in hippocampal neurons (PubMed:17310244).
messages: Postsynapse
messages: Postsynaptic density
messages: Presynapse
messages: Synapse
messages: The coiled coil region mediates dimerization.
messages: Widely expressed (PubMed:9826657). Expressed at high levels in testis (at protein level) (PubMed:10938112). Expressed in the brain, including in CA1 hippocampal neurons, in the amygdala, and thalamic nuclei (at protein level) (PubMed:10938112, PubMed:12473661, PubMed:12695502, PubMed:12629171, PubMed:15800193, PubMed:17310244, PubMed:24297929, PubMed:25284783).
messages: centrosome
messages: focal adhesion
messages: lamellipodium
messages: spindle pole

10116:Ptx3
gene id: 10116:Ptx3
uniprot id: A6J5K6
uniprot id: D3ZT94
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Atp5mg
gene id: 10116:Atp5mg
uniprot id: Q6PDU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase g subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion
messages: Mitochondrion inner membrane

10116:Rcvrn
gene id: 10116:Rcvrn
uniprot id: Q8VH47
names: Similarity
messages: Belongs to the recoverin family.

10116:Dpp4
gene id: 10116:Dpp4
uniprot id: P14740
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the peptidase S9B family. DPPIV subfamily.
messages: Cell junction
messages: Cell membrane
messages: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
messages: Expressed in bile ducts and other epithelial brush borders (small intestine, kidney, colon, pancreatic duct); acinar structures in salivary glands; endothelial structures and T cell areas in thymus, spleen and lymph node.
messages: Inhibited by GPC3 and diprotin A.
messages: Membrane raft
messages: Monomer. Homodimer. Heterodimer with Seprase (FAP). Requires homodimerization for optimal dipeptidyl peptidase activity and T-cell costimulation. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Associates with collagen. Interacts with PTPRC; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes. Interacts (via extracellular domain) with ADA; does not inhibit its dipeptidyl peptidase activity. Interacts with CAV1 (via the N-terminus); the interaction is direct. Interacts (via cytoplasmic tail) with CARD11 (via PDZ domain); its homodimerization is necessary for interaction with CARD11. Interacts with IGF2R; the interaction is direct. Interacts with GPC3.
messages: N- and O-Glycosylated.
messages: Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation (By similarity).
messages: Secreted
messages: The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing.
messages: invadopodium membrane
messages: lamellipodium membrane

10116:Ttc39c
gene id: 10116:Ttc39c
uniprot id: A6KLR6
uniprot id: Q0VGK2
names: Similarity
messages: Belongs to the TTC39 family.

10116:Or5d14
gene id: 10116:Or5d14
uniprot id: A6HN15
uniprot id: D4A607
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Or51a41
gene id: 10116:Or51a41
uniprot id: M0RBR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Abcd4
gene id: 10116:Abcd4
uniprot id: A6JDX5
names: Subcellular Location Annotation
messages: Membrane

10116:Pard3b
gene id: 10116:Pard3b
uniprot id: A0A8I5ZQH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR3 family.
messages: Cell junction
messages: Endomembrane system

10116:Cacng1
gene id: 10116:Cacng1
uniprot id: P97707
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1 (Probable). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2 (By similarity).
messages: N-glycosylated.
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: Skeletal muscle.
messages: sarcolemma

10116:Pigs
gene id: 10116:Pigs
uniprot id: A6HH43
uniprot id: Q5XI31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIGS family.
messages: Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates (By similarity).
messages: Endoplasmic reticulum membrane
messages: Forms a complex with PIGK/GPI8, PIGT, PIGU and GAA1.
messages: Membrane

10116:Or1f19
gene id: 10116:Or1f19
uniprot id: D4A222
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Hpf1
gene id: 10116:Hpf1
uniprot id: A6KIS6
names: Similarity
messages: Belongs to the HPF1 family.

10116:Or10j3
gene id: 10116:Or10j3
uniprot id: A0A8I5ZS83
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Pmp2
gene id: 10116:Pmp2
uniprot id: A6IH48
uniprot id: D3ZFG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

10116:Nmbr
gene id: 10116:Nmbr
uniprot id: A6JP76
uniprot id: P24053
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Brain (olfactory bulb and central thalamic regions), and esophagus.
messages: Cell membrane
messages: Membrane
messages: Receptor for neuromedin-B (PubMed:1848080). Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (By similarity). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity).

10116:Arfip1
gene id: 10116:Arfip1
uniprot id: Q9JHU5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms homodimers or heterodimers with ARFIP2. Interacts with non-myristoylated GTP-bound ARF3, but not to GDP-bound ARF3. Interacts with ARF1. Binds with lower affinity to ARF5 and with very little affinity to ARF6. Interacts with ARL1. Interacts with ATG9A.
messages: Golgi apparatus
messages: Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells.
messages: trans-Golgi network membrane

10116:Igf1r
gene id: 10116:Igf1r
uniprot id: P24062
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by autophosphorylation at Tyr-1162, Tyr-1166 and Tyr-1167 on the kinase activation loop; phosphorylation at all three tyrosine residues is required for optimal kinase activity. Inhibited by MSC1609119A-1, BMS-754807, PQIP, benzimidazole pyridinone, isoquinolinedione, bis-azaindole, 3-cyanoquinoline, 2,4-bis-arylamino-1,3-pyrimidine, pyrrolopyrimidine, pyrrole-5-carboxaldehyde, picropodophyllin (PPP), tyrphostin derivatives. While most inhibitors bind to the ATP binding pocket, MSC1609119A-1 functions as allosteric inhibitor and binds close to the DFG motif and the activation loop (By similarity). Dephosphorylated by PTPN1 (By similarity).
messages: Autophosphorylated on tyrosine residues in response to ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Autophosphorylation occurs in a sequential manner; Tyr-1166 is predominantly phosphorylated first, followed by phosphorylation of Tyr-1162 and Tyr-1167. While every single phosphorylation increases kinase activity, all three tyrosine residues in the kinase activation loop (Tyr-1162, Tyr-1166 and Tyr-1167) have to be phosphorylated for optimal activity. Can be autophosphorylated at additional tyrosine residues (in vitro). Autophosphorylated is followed by phosphorylation of juxtamembrane tyrosines and C-terminal serines. Phosphorylation of Tyr-981 is required for IRS1- and SHC1-binding. Phosphorylation of Ser-1279 by GSK-3beta restrains kinase activity and promotes cell surface expression, it requires a priming phosphorylation at Ser-1283 (By similarity). Dephosphorylated by PTPN1.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Controlled by regulated intramembrane proteolysis (RIP). Undergoes metalloprotease-dependent constitutive ectodomain shedding to produce a membrane-anchored 52 kDa C-Terminal fragment which is further processed by presenilin gamma-secretase to yield an intracellular 50 kDa fragment (By similarity).
messages: Polyubiquitinated at Lys-1169 and Lys-1172 through both 'Lys-48' and 'Lys-29' linkages, promoting receptor endocytosis and subsequent degradation by the proteasome. Ubiquitination is facilitated by pre-existing phosphorylation (By similarity).
messages: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylati…
messages: Sumoylated with SUMO1.
messages: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Forms a hybrid receptor with INSR, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with RACK1 (By similarity). Interacts with SOCS1, SOCS2 and SOCS3 (By similarity). Interacts with 14-3-3 proteins (By similarity). Interacts with NMD2 (By similarity). Interacts with MAP3K5 (By similarity). Interacts with STAT3. Found in a ternary complex with IGF1 and ITGAV:ITGB3 or ITGA6:ITGB4 (By similarity). Interacts (nascent precursor form) with ZFAND2B (By similarity).

10116:Rps24
gene id: 10116:Rps24
uniprot id: A0A8I5ZX70
uniprot id: A6KMF4
uniprot id: A6KMF5
uniprot id: A6KMF6
uniprot id: P62850
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: Cytoplasm
messages: nucleolus

10116:Or13d1
gene id: 10116:Or13d1
uniprot id: A6KDN4
uniprot id: F1LW03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Sbk2
gene id: 10116:Sbk2
uniprot id: B1WBU5
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.

10116:Uros
gene id: 10116:Uros
uniprot id: F7ET42
uniprot id: Q5XIF2
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

10116:Cyp7b1
gene id: 10116:Cyp7b1
uniprot id: Q63688
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Highly expressed in brain; also expressed in liver and kidney.
messages: Microsome membrane
messages: Oxysterol 7alpha-hydroxylase that mediates formation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) from 25-hydroxycholesterol. Plays a key role in cell positioning and movement in lymphoid tissues: 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.

10116:Pfn3
gene id: 10116:Pfn3
uniprot id: M0RCP6
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and phosphatidylinositol 4-phosphate (PtdIns(4)P). May be involved in spermatogenesis.
messages: Cytoplasm
messages: Detected in round spermatids.
messages: Expression coincides with the increasing numbers of round spermatids and decreases during the termination of the first spermatogenic cycle.
messages: Interacts with ACTRT3.
messages: Nucleus
messages: cytoskeleton

10116:Lum
gene id: 10116:Lum
uniprot id: P51886
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to laminin.
messages: Contains keratan sulfate.
messages: extracellular matrix

10116:Ralgds
gene id: 10116:Ralgds
uniprot id: Q03386
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in all tissues examined.
messages: Functions as a guanine nucleotide exchange factor (GEF) activating either RalA or RalB GTPases and plays an important role in intracellular transport. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. During bacterial clearance, recognizes 'Lys-33'-linked polyubiquitinated TRAF3 and subsequently mediates assembly of the exocyst complex.
messages: Interacts with RIT1 and RIT2 (By similarity). Interacts with TRAF3. Interacts with HRAS (By similarity).
messages: Nucleus
messages: Phosphorylation of Tyr-795 by MET blocks HRAS binding.
messages: The Ras-associating domain interacts with Ras.

10116:Fem1a
gene id: 10116:Fem1a
uniprot id: Q4V890
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fem-1 family.
messages: Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter FEM1A. Interacts with PTGER4 (By similarity). Interacts with NFKB1; the interaction is direct (By similarity).
messages: Cytoplasm
messages: Mitochondrion
messages: Phosphorylated; highly phosphorylated in myoblasts and myotubes. Phosphorylation at Ser-108 and Ser-608 promote PGE2-EP4-mediated inhibition of inflammation. Dephosphorylated by protein phosphatase 2A (PP2A).
messages: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (By similarity). Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (By similarity).

10116:Or2a25
gene id: 10116:Or2a25
uniprot id: D4AEF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Itih3
gene id: 10116:Itih3
uniprot id: Q63416
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ITIH family.
messages: Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.
messages: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (HC) and one light chain, bikunin. Pre-alpha-inhibitor (P-alpha-I) is composed of ITIH3/HC3 and bikunin.
messages: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
messages: Secreted

10116:Sgip1
gene id: 10116:Sgip1
uniprot id: A0A8I5ZUM5
uniprot id: A0A8I6AMB7
uniprot id: P0DJJ3
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Interacts with proteins essential or regulating the formation of functional clathrin-coated pits (Probable). Interacts with CANX (By similarity). Interacts with AP2A1 (By similarity). Interacts with EPS15 (By similarity). Interacts with SH3GL3 (By similarity). Interacts with AMPH (By similarity). Interacts with ITSN1 (via SH3 domains) (By similarity). Interacts with and REPS1 (By similarity).
messages: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.
messages: Specifically expressed in brain (at protein level).
messages: clathrin-coated pit

10116:Pole
gene id: 10116:Pole
uniprot id: D3Z8X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: DNA polymerase II participates in chromosomal DNA replication.
messages: Nucleus

10116:Doc2a
gene id: 10116:Doc2a
uniprot id: P70611
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: C2 domain 1 is involved in binding calcium and phospholipids.
messages: Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells (By similarity).
messages: Interacts (via N-terminus) with UNC13A. Interacts with cytoplasmic dynein light chain DYNLT1. Interacts with UNC13D (By similarity).
messages: Lysosome
messages: Predominantly expressed in brain. Also found in non-neural tissues. Expressed in RBL-2H3 mast cell line.
messages: synaptic vesicle membrane
messages: synaptosome

10116:Abcg3l4
gene id: 10116:Abcg3l4
uniprot id: Q498U1
names: Subcellular Location Annotation
messages: Membrane

10116:Stk11
gene id: 10116:Stk11
uniprot id: D4AE59
names: Activity Regulation
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated. Deacetylation at Lys-48 enhances cytoplasmic localization and kinase activity in vitro.
messages: Activated by forming a complex with STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): STRADA (or STRADB)-binding promotes a conformational change of STK11/LKB1 in an active conformation, which is stabilized by CAB39/MO25alpha (or CAB39L/MO25beta) interacting with the STK11/LKB1 activation loop. Sequestration in the nucleus by NR4A1 prevents it from phosphorylating and activating cytoplasmic AMPK (By similarity).
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
messages: Catalytic component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Found in a ternary complex composed of SMAD4, STK11/LKB1 and STK11IP (By similarity). Interacts with NR4A1, p53/TP53, SMAD4, STK11IP and WDR6 (By similarity). Interacts with NISCH; this interaction may increase STK11 activity (By similarity). Interacts with SIRT1; the interaction deacetylates STK11 (By similarity). Interacts with CDKN1A (By similarity).
messages: Cytoplasm
messages: Expressed in brain, heart, testis, skeletal muscle and spleen, and weakly in liver and kidney. Isoform 1 is expressed at highest levels in the brain. Isoform 2 is expressed at highest levels in the testis, primarily in postmitotic developing germ cells (at protein level).
messages: Has a role in spermiogenesis.
messages: Isoform 2 is expressed in testis from 30 days of age, with significantly increased levels by 60 days; this corresponds to the stage when haploid spermatids appear.
messages: Membrane
messages: Mitochondrion
messages: Nucleus
messages: Phosphorylated by ATM at Thr-366 following ionizing radiation (IR). Phosphorylation at Ser-431 by RPS6KA1 and/or some PKA is required to inhibit cell growth. Phosphorylation at Ser-431 is also required during neuronal polarization to mediate phosphorylation of BRSK1 and BRSK2. Phosphorylation by PKC/PRKCZ at Ser-397 in isoform 2 promotes metformin (or peroxynitrite)-induced nuclear export of STK11 and activation of AMPK. UV radiation -induced phosphorylation at Thr-366 mediates CDKN1A degradation.
messages: Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (By similarity).

10116:Exoc3l4
gene id: 10116:Exoc3l4
uniprot id: A6KBQ7
uniprot id: F7F7D0
names: Similarity
messages: Belongs to the SEC6 family.

10116:Tssk1b
gene id: 10116:Tssk1b
uniprot id: A0A8I6AN48
uniprot id: Q6V9Y2
names: Similarity
messages: Belongs to the protein kinase superfamily.

10116:Cd5
gene id: 10116:Cd5
uniprot id: A6I055
uniprot id: P51882
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1 (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May act as a receptor in regulating T-cell proliferation.
messages: Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.

10116:Adamts18
gene id: 10116:Adamts18
uniprot id: D3Z8G4
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

10116:Pip4k2a
gene id: 10116:Pip4k2a
uniprot id: Q9R0I8
names: Activity Regulation
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities. May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (By similarity). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (PubMed:20204506). Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (By similarity). In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (By similarity). Negatively regulates insulin signaling through a catalytic-independent mechanism. PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:21847559). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer. Interacts with PIP4K2B; the interaction may regulate localization to the nucleus (By similarity). Probably interacts with PIP5K1A; the interaction inhibits PIP5K1A kinase activity (By similarity).
messages: In rod outer segments, activated by light.
messages: Lysosome
messages: Nucleus
messages: Phosphorylated in tyrosines. Phosphorylation is induced by light and increases kinase activity.
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

10116:Stn1
gene id: 10116:Stn1
uniprot id: A0A0H2UHR9
uniprot id: A6JHQ6
uniprot id: Q6AYD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres. Promotes general replication start following replication-fork stalling implicating new origin firing. May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication (By similarity).
messages: Component of the CST complex, composed of TEN1/C17orf106, CTC1/C17orf68 and STN1; in the complex interacts directly with TEN1 and CTC1. Interacts with ACD/TPP1, POT1 and POLA1.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

10116:Adam30
gene id: 10116:Adam30
uniprot id: A6K3D0
uniprot id: D3ZIP6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Gsk3b
gene id: 10116:Gsk3b
uniprot id: A0A0G2JSH4
uniprot id: A0A0G2KB98
uniprot id: A6IR80
uniprot id: P18266
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by phosphorylation at Tyr-216. In response to insulin, inhibited by phosphorylation at Ser-9 by PKB/AKT1; phosphorylation at this site causes a conformational change, preventing access of substrates to the active site (By similarity). Inhibited by IL22 treatment which also triggers phosphorylation at Ser-9, promoting inactivation (By similarity). Inhibited by lithium (By similarity).
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
messages: Cell membrane
messages: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates (PubMed:9482734). In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (By similarity). Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase (By similarity). In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes (PubMed:9482734). Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA) …
messages: Cytoplasm
messages: Membrane
messages: Mono-ADP-ribosylation by PARP10 negatively regulates kinase activity.
messages: Monomer (By similarity). Interacts with DAB2IP (via C2 domain); the interaction stimulates GSK3B kinase activation (By similarity). Interacts (via C2 domain) with PPP2CA (By similarity). Interacts with ARRB2, AXIN1, CABYR, DISC1, MMP2, MUC1, NIN, PRUNE1 and ZBED3 (By similarity). Interacts with AXIN1; the interaction mediates hyperphosphorylation of CTNNB1 leading to its ubiquitination and destruction (PubMed:9482734). Interacts with and phosphorylates SNAI1 (By similarity). Interacts with DNM1L (via a C-terminal domain) (By similarity). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (PubMed:16815997). Interacts with SGK3 (By similarity). Interacts with the CLOCK-BMAL1 heterodimer (By similarity). Interacts with the BMAL1 (By similarity). Interacts with CTNND2 (By similarity). The complex composed, at least, of APC, CTNNB1 and GSK3B interacts with JPT1; the interaction requires the inactive form of GSK3B (phosphorylated at 'Ser-9') (By similarity). Forms a complex composed of PRKAR2A or PRKAR2B, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation and regulates GSK3B activity (By similarity). Interacts with GSKIP (By similarity). Interacts with GID8 (By similarity). Interacts with PIWIL2 (By similarity). Interacts with LMBR1L (By similarity). Interacts with DDX3X (By similarity). Interacts with BIRC2 (By similarity). Interacts with TNFRSF10B; TNFRSF10B stimulation inhibits GSK3B kinase activity (By similarity). Found in a complex with SLC39A6, SLC39A10 and with GSK3B that controls NCAM1 phosphorylation (By similarity).
messages: Nucleus
messages: Phosphorylated by AKT1 and ILK1. Upon insulin-mediated signaling, the activated PKB/AKT1 and RPS6KA3 protein kinases phosphorylate and deactivate GSK3B, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-216 (By similarity). Inactivated by phosphorylation at Ser-9 (By similarity). Phosphorylated in a circadian manner in the hippocampus (By similarity).
messages: Simultaneous silencing of GSK3A and GSK3B by RNAi stimulates replication and promotes survival of INS-1E pancreatic beta cells.

10116:Suclg2
gene id: 10116:Suclg2
uniprot id: B1H270
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

10116:Cps1
gene id: 10116:Cps1
uniprot id: A6KFE3
uniprot id: P07756
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: 50% of the mature protein that was isolated had Leu-39 as its N-terminal residue and 50% had Ser-40 suggesting two adjacent processing sites. However, the possibility of proteolytic removal of Leu-39 during the isolation of the enzyme cannot be excluded. Undergoes proteolytic cleavage in the C-terminal region corresponding to the loss of approximately 12 AA residues from the C-terminus (PubMed:23649895).
messages: Can form homooligomers (monomers as predominant form and dimers).
messages: Cell membrane
messages: Glutarylated. Glutarylation levels increase during fasting. Deglutarylated by SIRT5 at Lys-55, Lys-219, Lys-412, Lys-889, Lys-892, Lys-915, Lys-1360 and Lys-1486, leading to activation.
messages: Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Primarily in the liver and small intestine.
messages: Requires N-acetyl-L-glutamate (NAG) as an allosteric activator. N-acetyl-L-beta-phenylglutamate (Phe-NAG) can also activate CPSase I, but with an activation constant that is 2-fold higher than that for NAG.
messages: Succinylated at Lys-287 and Lys-1291. Desuccinylated at Lys-1291 by SIRT5, leading to activation (By similarity).
messages: The type-1 glutamine amidotransferase domain is defective.
messages: nucleolus

10116:Zp3
gene id: 10116:Zp3
uniprot id: P97708
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Expressed in oocytes.
messages: N-glycosylated; N-linked glycans are of high mannose/hybrid type, as well as bi-, tri- and tetra-antennary complex types.
messages: O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy.
messages: Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers. Interacts with ZP1 and ZP2.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

10116:Lgi2
gene id: 10116:Lgi2
uniprot id: B5DF14
names: Subcellular Location Annotation
messages: Secreted

10116:Il17rb
gene id: 10116:Il17rb
uniprot id: B5DF15
names: Subcellular Location Annotation
messages: Membrane

10116:Bcl9l
gene id: 10116:Bcl9l
uniprot id: A0A8I6AJN4
uniprot id: A6J400
uniprot id: D4A0D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

10116:Epyc
gene id: 10116:Epyc
uniprot id: A6IG69
uniprot id: B1WBV5
uniprot id: G3V6L6
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

10116:Sema3c
gene id: 10116:Sema3c
uniprot id: B5DFL7
uniprot id: F7FHT4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

10116:Cdk6
gene id: 10116:Cdk6
uniprot id: A6K295
uniprot id: F1MA87
names: Similarity
messages: Belongs to the protein kinase superfamily.

10116:Tubb3
gene id: 10116:Tubb3
uniprot id: A6IZY2
uniprot id: Q4QRB4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with UNC5C (via cytoplasmic domain); this interaction is decreased by NTN1/Netrin-1 (By similarity). Interacts with NLRP5/MATER at cytoskeleton microtubules (By similarity). Interacts with DPYSL5 (By similarity).
messages: Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility.
messages: The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.
messages: The highly acidic C-terminal region may bind cations such as calcium.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB3 plays a critical role in proper axon guidance and maintenance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord.
messages: cytoskeleton
messages: filopodium
messages: growth cone
messages: lamellipodium

10116:Krt24
gene id: 10116:Krt24
uniprot id: Q6IFX1
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Heterotetramer of two type I and two type II keratins.
messages: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

10116:Hps3
gene id: 10116:Hps3
uniprot id: A0A8I5ZU61
uniprot id: A6IHC6
uniprot id: D3ZGG8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: Cytoplasm
messages: Involved in early stages of melanosome biogenesis and maturation.

10116:Selenoi
gene id: 10116:Selenoi
uniprot id: A0A9K3Y7I0
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

10116:Zcchc7
gene id: 10116:Zcchc7
uniprot id: B1WC15
names: Subcellular Location Annotation
names: Subunit
messages: Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (MTREX), an oligadenylate polymerase (TENT4B or TENT4A), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes (By similarity).
messages: nucleolus

10116:Camkmt
gene id: 10116:Camkmt
uniprot id: B0K012
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CLNMT methyltransferase family.
messages: Catalyzes the trimethylation of 'Lys-116' in calmodulin.
messages: Cytoplasm
messages: Monomer (Probable). Interacts with HSP90, probably as a client (By similarity).
messages: Nucleus

10116:Nefh
gene id: 10116:Nefh
uniprot id: F1LRZ7
names: Similarity
messages: Belongs to the intermediate filament family.

10116:Hoxb4
gene id: 10116:Hoxb4
uniprot id: A6HIE7
uniprot id: F7EXS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

10116:Aqp2
gene id: 10116:Aqp2
uniprot id: P34080
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Basolateral cell membrane
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Detected in kidney, in cortical and the medullary collecting tubules (at protein level) (PubMed:8429910). Detected in kidney medulla and cortex (PubMed:8429910, PubMed:7508187).
messages: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (PubMed:8429910, PubMed:7508187). Plays an essential role in renal water homeostasis (By similarity).
messages: Homotetramer.
messages: N-glycosylated.
messages: Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent.
messages: trans-Golgi network membrane

10116:Stimate
gene id: 10116:Stimate
uniprot id: Q7TSW6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts by interacting with STIM1, promoting STIM1 conformational switch. Involved in STIM1 relocalization to ER-PM junctions. Contributes to the maintenance and reorganization of store-dependent ER-PM junctions.
messages: Belongs to the STIMATE family.
messages: Endoplasmic reticulum membrane
messages: Homooligomer. Interacts with STIM1.
messages: The GXXXG motif may mediate oligomerization. The C-terminus is necessary for its localization at ER-plasma membrane (ER-PM) junctions as well as for the store-dependent rearrangement of ER-PM junctions.

10116:Hras
gene id: 10116:Hras
uniprot id: P20171
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Forms a signaling complex with RASGRP1 and DGKZ (By similarity). In its GTP-bound form interacts with PLCE1 (PubMed:11179219). Interacts with TBC1D10C (By similarity). Interacts with RGL3 and RASSF5 (By similarity). Interacts with HSPD1 (By similarity). Interacts with PDE6D (By similarity). Interacts with IKZF3 (By similarity). Interacts with RACK1 (By similarity). Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14 (PubMed:19319189). Interacts (active GTP-bound form) with RGS14 (via RBD 1 domain) (PubMed:19319189, PubMed:19878719). Interacts with PIK3CG; the interaction is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6 (By similarity). Interacts with RAPGEF2 (By similarity). Interacts (in GTP-bound form) with Oog1 (By similarity).
messages: Golgi apparatus
messages: Golgi apparatus membrane
messages: Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
messages: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
messages: S-nitrosylated; critical for redox regulation. Important for stimulating guanine nucleotide exchange. No structural perturbation on nitrosylation.
messages: The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation.
messages: Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.

10116:Rrh
gene id: 10116:Rrh
uniprot id: A6HVP7
uniprot id: D3ZY73
names: Subcellular Location Annotation
messages: Membrane

10116:Olr1130
gene id: 10116:Olr1130
uniprot id: D3ZMP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Cnep1r1
gene id: 10116:Cnep1r1
uniprot id: A6KDA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

10116:Pgc
gene id: 10116:Pgc
uniprot id: A6JII4
uniprot id: P04073
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Hydrolyzes a variety of proteins.
messages: Secreted

10116:Fam98c
gene id: 10116:Fam98c
uniprot id: Q6AYE6
names: Similarity
messages: Belongs to the FAM98 family.

10116:Adarb1
gene id: 10116:Adarb1
uniprot id: P51400
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds 1 myo-inositol hexakisphosphate (IP6) per subunit.
messages: Brain and peripheral tissues.
messages: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently (By similarity). Can inhibit cell proliferation and migration and can stimulate exocytosis.
messages: Homodimer. Homodimerization is essential for its catalytic activity (By similarity).
messages: Nucleus
messages: nucleolus

10116:Pglyrp1
gene id: 10116:Pglyrp1
uniprot id: Q9JLN4
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: By sleep deprivation in the brain stem and in the hypothalamus.
messages: Cytoplasmic granule
messages: Expressed in all regions of the brain.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity. Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity. Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor.
messages: Secreted

10116:Slc46a3
gene id: 10116:Slc46a3
uniprot id: A6K192
uniprot id: Q5BK75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. SLC46A family.
messages: Lysosomal proton-coupled steroid conjugate and bile acid transporter. Preferentially recognizes lipophilic steroid conjugates or bile acis as endogenous substrates and seems to mediate escape from lysosomes to the cytoplasm (By similarity). Modulates hepatic cytosolic copper homeostasis, maybe acting as a lysosomal copper transporter and sequestering copper ions in the lysosome (By similarity). Delivers pathogen-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes. Selectively transports bacterial muramyl dipeptide (MDP) into the cytosol for recognition by NOD2, triggering inflammatory responses (By similarity). Likely acts as a redundant importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages. The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (By similarity).
messages: Lysosome membrane
messages: Membrane

10116:Fggy
gene id: 10116:Fggy
uniprot id: Q5FVC3
names: Similarity
messages: Belongs to the FGGY kinase family.

10116:Pla2g4a
gene id: 10116:Pla2g4a
uniprot id: Q6IRF5
names: Domain
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.

10116:Scube2
gene id: 10116:Scube2
uniprot id: D4AC02
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

10116:Ark2n
gene id: 10116:Ark2n
uniprot id: A6KMV4
uniprot id: D4A3X1
names: Subcellular Location Annotation
messages: Nucleus

10116:Ncl
gene id: 10116:Ncl
uniprot id: A6JWG9
uniprot id: F7EJZ2
names: Function
names: Subcellular Location Annotation
messages: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
messages: nucleolus

10116:Arid5a
gene id: 10116:Arid5a
uniprot id: A0A0G2K0Q5
uniprot id: A6INC7
names: Subcellular Location Annotation
messages: Nucleus

10116:Cyp2g1
gene id: 10116:Cyp2g1
uniprot id: A6J9A3
uniprot id: P10610
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. This isozyme seems to be implicated in olfaction.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Olfactory epithelium.

10116:Cyb5d2
gene id: 10116:Cyb5d2
uniprot id: Q6AY62
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b5 family. MAPR subfamily.
messages: Heme-binding protein which promotes neuronal but not astrocyte differentiation.
messages: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
messages: Secreted
messages: The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residues at position 73 and 106.

10116:Olr1285
gene id: 10116:Olr1285
uniprot id: A0A0G2K9G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Atxn7l3
gene id: 10116:Atxn7l3
uniprot id: D4A5H7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGF11 family.
messages: Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ENY2 and USP22.
messages: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B.
messages: Nucleus
messages: The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of USP22 forms the 'catalytic lobe' of the SAGA deubiquitination module.
messages: The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.

10116:Adgre5
gene id: 10116:Adgre5
uniprot id: Q5XI36
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Tbc1d31
gene id: 10116:Tbc1d31
uniprot id: D3ZTA2
names: Function
names: Subcellular Location Annotation
messages: Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.
messages: centriolar satellite
messages: cilium basal body

10116:Ube2m
gene id: 10116:Ube2m
uniprot id: A0A8I5ZYZ8
uniprot id: A6KQK5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

10116:Negr1
gene id: 10116:Negr1
uniprot id: Q9Z0J8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. IgLON family.
messages: Cell membrane
messages: Glycosylated.
messages: Highly expressed in brain.
messages: May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).

10116:Erich6
gene id: 10116:Erich6
uniprot id: Q5XI56
names: Similarity
messages: Belongs to the ERICH6 family.

10116:Prl5a2
gene id: 10116:Prl5a2
uniprot id: Q1KZI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

10116:Olr1055
gene id: 10116:Olr1055
uniprot id: D3ZFB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Elovl6
gene id: 10116:Elovl6
uniprot id: A6HVP0
uniprot id: Q920L6
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Expressed in liver and barely in brain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.
messages: The reaction is stimulated by the presence of HSD17B12, the enzyme catalyzing the second step of the elongation cycle.

10116:Cnot9
gene id: 10116:Cnot9
uniprot id: A6JVU9
uniprot id: Q5PQL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CNOT9 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors. May play a role in cell differentiation (By similarity).
messages: Detected in adult spleen, thymus, testis, bone marrow, lung and brain. Detected in embryonic brain, liver, lung, intestine, heart, kidney, thymus and spleen (at protein level).
messages: Homodimer. Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. Interacts with MYB, ATF2, RARA, RARB, RARG, RXRA, RXRB and RXRG. Identified in a complex with ATF2 bound to target DNA. Interacts with NANOS2. Directly interacts with ZNF335.
messages: Nucleus
messages: P-body

10116:Olr1108
gene id: 10116:Olr1108
uniprot id: A0A8I5Y718
uniprot id: Q5USB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Or13p8b
gene id: 10116:Or13p8b
uniprot id: M0R571
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Nol8
gene id: 10116:Nol8
uniprot id: M0RDX9
names: Subcellular Location Annotation
messages: nucleolus

10116:Panx1
gene id: 10116:Panx1
uniprot id: A6JNB1
uniprot id: E0X643
uniprot id: P60570
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Expressed in the eye, thyroid, prostate, kidney and liver. Abundantly expressed in the CNS, including hippocampus, olfactory bulb, cortex, cerebellum and white matter.
messages: Homohexamer (By similarity). Forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes.
messages: Membrane
messages: S-nitrosylation inhibits channel currents and ATP release.
messages: Structural component of the gap junctions and the hemichannels.
messages: Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (By similarity).
messages: gap junction

10116:Tlr11
gene id: 10116:Tlr11
uniprot id: F7EMB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

10116:Abca6
gene id: 10116:Abca6
uniprot id: M0R890
names: Subcellular Location Annotation
messages: Membrane

10116:Cryba2
gene id: 10116:Cryba2
uniprot id: F7ET28
uniprot id: Q8CGQ0
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

10116:Cnga2
gene id: 10116:Cnga2
uniprot id: Q00195
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily.
messages: Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons (By similarity).
messages: It is uncertain whether Met-1 or Met-2 is the initiator.
messages: Membrane
messages: Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.
messages: Olfactory neurons.
messages: The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.

10116:Ppib
gene id: 10116:Ppib
uniprot id: P24368
names: Activity Regulation
names: Caution
names: Function
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
messages: Endoplasmic reticulum lumen
messages: Higher levels occur in the proximal convoluted tubule of strain SHR than strain Wistar Kyoto.
messages: Inhibited by cyclosporin A (CsA).
messages: Interacts with DYM. Interacts with CALR, CLGN and CANX. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.
messages: It is uncertain whether Met-1 or Met-9 is the initiator.
messages: Melanosome
messages: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.
messages: Widely expressed with highest levels in kidney.

10116:Dcc
gene id: 10116:Dcc
uniprot id: A0A8I6ATC8
uniprot id: Q63155
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Detected in embryonic spinal cord, predominantly in axons of commissural neurons (at protein level). Detected in embryonic spinal cord.
messages: Interacts with the cytoplasmic part of UNC5A, UNC5B and UNC5C (PubMed:10399920). Interacts with DSCAM (By similarity). Interacts with PTK2/FAK1 (By similarity). Interacts with MYO10 (By similarity). Interacts with MAPK1 (PubMed:21070949). Interacts with NTN1 (PubMed:8861902). Interacts with CBLN4; this interaction can be competed by NTN1 (By similarity). Interacts with SIAH1 and SIAH2 (By similarity).
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene (By similarity).
messages: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.

10116:Agtr1b
gene id: 10116:Agtr1b
uniprot id: P29089
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: C-terminal Ser or Thr residues may be phosphorylated.
messages: Cell membrane
messages: Interacts with MAS1 (By similarity). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity).
messages: Is expressed in the liver, kidney, aorta, lung, uterus, ovary, spleen, heart, and vascular smooth muscle cell. Expressed most abundantly in the adrenal gland.
messages: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.

10116:Por
gene id: 10116:Por
uniprot id: A6J0C1
uniprot id: P00388
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

10116:Bccip
gene id: 10116:Bccip
uniprot id: A6HX34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
messages: Nucleus
messages: spindle pole

10116:Fut8
gene id: 10116:Fut8
uniprot id: D4IGX4
uniprot id: D4IGX5
uniprot id: Q6EV76
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane
messages: Tyrosine phosphorylated by PKDCC/VLK.

10116:Cstdc2
gene id: 10116:Cstdc2
uniprot id: A6K7D8
uniprot id: D3ZMP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted

10116:Parva
gene id: 10116:Parva
uniprot id: A0A8I6AA82
uniprot id: Q9HB97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the parvin family.
messages: Cell membrane
messages: Interacts with TGFB1I1 (PubMed:11134073). Interacts with LIMS1 (via LD motifs) (By similarity). Interacts with ARHGAP31 (By similarity). Interacts with the actin cytoskeleton (PubMed:11134073). Interacts (via C-terminus) with ILK (By similarity). Interacts (via C-terminus) with TESK1 (via C-terminus); the interaction inhibits TESK1 kinase activity (PubMed:15817463). Interacts with PXN/PAXILLIN (via LD motif 4) (PubMed:11134073).
messages: Membrane
messages: Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration.
messages: Widely expressed.
messages: Z line
messages: cytoskeleton
messages: focal adhesion

10116:Serpinb9
gene id: 10116:Serpinb9
uniprot id: A0A8I6A0T8
uniprot id: A0A8I6AGW0
uniprot id: Q6AYF8
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

10116:Rps6kb2
gene id: 10116:Rps6kb2
uniprot id: A6HYU9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

10116:Ccnj
gene id: 10116:Ccnj
uniprot id: A6JH64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family.
messages: Nucleus

10116:Xkr7
gene id: 10116:Xkr7
uniprot id: Q5GH56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Cell membrane

10116:Idi1
gene id: 10116:Idi1
uniprot id: A0A0H2UHN2
uniprot id: A6KRN6
uniprot id: O35760
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Monomer.
messages: Peroxisome

10116:Atp13a2
gene id: 10116:Atp13a2
uniprot id: B5DEH6
uniprot id: F1MAA4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Or52s19
gene id: 10116:Or52s19
uniprot id: A6I795
uniprot id: D4A9S9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Pih1d2
gene id: 10116:Pih1d2
uniprot id: D3ZRH4
names: Similarity
messages: Belongs to the PIH1 family.

10116:Spg21
gene id: 10116:Spg21
uniprot id: A0A8I6GKW0
uniprot id: Q5XIC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily.
messages: Cytoplasm
messages: Interacts with CD4. Interacts with ALDH16A1.
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

10116:Mdh1
gene id: 10116:Mdh1
uniprot id: A6JQ40
uniprot id: O88989
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-118 dramatically enhances enzymatic activity and promotes adipogenic differentiation.
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS).
messages: Homodimer.
messages: ISGylated.
messages: cytosol

10116:Slc52a2
gene id: 10116:Slc52a2
uniprot id: B5MEV3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Highly expressed in the placenta and small intestine, moderately in the kidney, colon, lung, prostate, uterus, and thymus, and weakly in all other tissues.
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. May also act as a receptor for 4-hydroxybutyrate.
messages: Riboflavin transport is Na(+)-independent but moderately pH-sensitive (By similarity). Activity is strongly inhibited by riboflavin analogs, such as lumiflavin (By similarity). Weakly inhibited by flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) (By similarity).

10116:Insrr
gene id: 10116:Insrr
uniprot id: A6J619
uniprot id: Q64716
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Expressed preferentially in the kidney. Also found in stomach and thymus but not in skeletal muscle, brain, intestine, and uterus.
messages: Membrane
messages: Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain (By similarity).
messages: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
messages: The extracellular domain is required for sensing alterations in external pH.

10116:Ap1m1
gene id: 10116:Ap1m1
uniprot id: A6K9P8
uniprot id: Q32Q06
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3) (By similarity). Interacts with MARCHF11.
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).
messages: clathrin-coated vesicle membrane

10116:MGC105649
gene id: 10116:MGC105649
uniprot id: Q5RK28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA4 subunit family.
messages: Nucleus

10116:Ssrp1
gene id: 10116:Ssrp1
uniprot id: A6HMS9
uniprot id: Q04931
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.
messages: Interacts with MYOG (via C-terminal region) (By similarity). Component of the FACT complex, a stable heterodimer of SSRP1 and SUPT16H. Also a component of a CK2-SPT16-SSRP1 complex which forms following UV irradiation, composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B. Binds to histone H3-H4 tetramers, but not to intact nucleosomes. Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1. Interacts with isoform gamma of TP63. Interacts with FYTTD1/UIF (By similarity). Interacts with SRF (PubMed:10336466). Interacts with NEK9 (By similarity).
messages: Nucleus
messages: Phosphorylated by CK2 following UV but not gamma irradiation. Phosphorylation inhibits its DNA-binding activity (By similarity).
messages: Sumoylated.
messages: Ubiquitinated. Polyubiquitinated following caspase cleavage resulting in degradation of the N-terminal ubiquitinated part of the cleaved protein (By similarity).
messages: nucleolus

10116:Zbtb10
gene id: 10116:Zbtb10
uniprot id: Q9WTY8
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed ubiquitously.
messages: May be involved in transcriptional regulation.
messages: Nucleus

10116:Clpp
gene id: 10116:Clpp
uniprot id: A6KQT9
uniprot id: M0RAD5
names: Similarity
messages: Belongs to the peptidase S14 family.

10116:Or51f2
gene id: 10116:Or51f2
uniprot id: A6I771
uniprot id: D3ZZ77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Grik1
gene id: 10116:Grik1
uniprot id: A0A140TAF9
uniprot id: A0A140TAG6
uniprot id: A6JL83
uniprot id: A6JL84
uniprot id: A6JL85
uniprot id: A6JL86
uniprot id: F1M7M9
uniprot id: P22756
names: Function
names: Miscellaneous
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily.
messages: Cell membrane
messages: Expressed in subsets of neurons throughout the developing and adult central and peripheral nervous systems. In the CNS principally in the medial amygdaloid nuclei, medial habenulae, pyriform and cingulate cortices, and Purkinje cell layer. Also highly expressed in embryonic and adult dorsal root ganglia.
messages: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). The unedited version (Q) assembles into a functional kainate-gated homomeric channel, whereas the edited version (R) is unable to produce channel activity when expressed alone. Both edited and unedited versions can form functional channels with GRIK4 and GRIK5. Interacts with KLHL17.
messages: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
messages: Membrane
messages: Partially edited.
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate > L-glutamate = quisqualate > CNQX = DNQX > AMPA > dihydrokainate > NMDA.

10116:Sdr42e1
gene id: 10116:Sdr42e1
uniprot id: A0A0G2JT58
uniprot id: A6IZH6
names: Similarity
messages: Belongs to the 3-beta-HSD family.

10116:Mcpt4
gene id: 10116:Mcpt4
uniprot id: P97592
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase S1 family. Granzyme subfamily.
messages: Cytoplasmic granule
messages: Mast cells.
messages: Secreted

10116:Fgf22
gene id: 10116:Fgf22
uniprot id: A0A7U3L4H9
uniprot id: Q8VI79
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

10116:Cptp
gene id: 10116:Cptp
uniprot id: Q5XIS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLTP family.
messages: Cell membrane
messages: Endosome membrane
messages: Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles. Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis.
messages: Nucleus outer membrane
messages: cytosol
messages: trans-Golgi network membrane

10116:Tpk1
gene id: 10116:Tpk1
uniprot id: A0A9K3Y7A3
uniprot id: B5DEJ6
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

10116:Olr1162
gene id: 10116:Olr1162
uniprot id: D4AC18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Rbmx
gene id: 10116:Rbmx
uniprot id: Q4V898
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Arg-182 is dimethylated, probably to asymmetric dimethylarginine.
messages: Expressed in brain, spleen, lung, liver, kidney, testis and heart. Weakly expressed in skeletal muscle (at protein level).
messages: Homomultimer (By similarity). Found in the supraspliceosome complex (PubMed:19282290) Identified in the spliceosome C complex (By similarity). Interacts with KHDRBS3 (By similarity). Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, NCOA5 and PPP1CA (By similarity). Interacts with SAFB/SAFB1 (By similarity). Interacts with ERAP1; the interaction is RNA-independent (By similarity). Interacts with CLK2, KHDRBS2, SAFB, TRA2B and YTHDC1 (PubMed:19282290). Interacts with PPIA/CYPA (By similarity).
messages: Nucleus
messages: O-glycosylated.
messages: RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.
messages: The RRM domain is necessary for RNA-binding, but not for splice site selection, indicating that its splicing activity does not require direct binding to RNA.

10116:Srm
gene id: 10116:Srm
uniprot id: Q99MI5
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

10116:Polr2b
gene id: 10116:Polr2b
uniprot id: A6JCV0
uniprot id: G3V8Y5
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

10116:Steap2
gene id: 10116:Steap2
uniprot id: A6K255
uniprot id: D4A6H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

10116:Smc3
gene id: 10116:Smc3
uniprot id: A6JHW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
messages: Nucleus
messages: centromere

10116:Ganc
gene id: 10116:Ganc
uniprot id: D4A7G5
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

10116:Lin7b
gene id: 10116:Lin7b
uniprot id: A6JB15
uniprot id: Q9Z252
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell junction
messages: Cell membrane
messages: Expressed only in brain.
messages: Forms two exclusive ternary complexes with CASK and CASKIN1 (PubMed:12040031). The brain-specific heterotrimeric complex (LIN-10-LIN-2-LIN-7 complex) composed of at least APBA1, CASK, and LIN7, associates with the motor protein KIF17 to transport vesicles along microtubules (By similarity). Forms a heterotrimeric complex composed of MMP5, LIN7B and PATJ; the N-terminal L27 domain of PALS1 interacts with the L27 domain of PATJ and the C-terminal L27 domain of PALS1 interacts with the L27 domain of LIN7B (By similarity). Forms a heterotrimeric complex with DLG1 and CASK via their L27 domains (PubMed:9753324, PubMed:14960569). Interacts with DLG4 and GRIN2B as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain (PubMed:10341223, PubMed:14960569). The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains (By similarity). Associates with KIF17 via APBA1 (PubMed:14960569). Interacts with ASIC3 (By similarity). Interacts with TOPK. Interacts with RTKN (By similarity). Interacts with APBA1 (PubMed:9753324, PubMed:14960569). Interacts with MPP7 (By similarity). Interacts with DLG2 (By similarity). Interacts with DLG3 (By similarity).
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).
messages: Postsynaptic density membrane
messages: The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.
messages: The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.
messages: The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.
messages: Up-regulated by cell depolarization and calcium entry through L-type calcium channels.
messages: tight junction

10116:Bcar3
gene id: 10116:Bcar3
uniprot id: D3ZAZ5
names: Caution
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (By similarity). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (PubMed:24216110). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (By similarity). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB/SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (By similarity). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (By similarity).
messages: Cytoplasm
messages: Part of a complex comprised of PTPRA, BCAR1, BCAR3 and SRC; the formation of the complex is dependent on integrin mediated-tyrosine phosphorylation of PTPRA (By similarity). Within the complex, interacts (via SH2 domain) with PTPRA (when phosphorylated on 'Tyr-792') (By similarity). Interacts (via Ras-GEF domain) with BCAR1 (PubMed:24216110). Interacts (via Ras-GEF domain) with NEDD9 (By similarity). Interacts with PTK2/FAK1 (By similarity). Interacts with PTPN1. Interacts (via SH2 domain) with EGFR (when tyrosine-phosphorylated) (By similarity).
messages: Phosphorylated on tyrosine residues.
messages: The Ras-GEF domain appears to adopt a closed conformation rendering it incapable of carrying out canonical exchange factor function, this closed conformation is probably required for interaction with BCAR1.
messages: The SH2 domain mediates interaction with tyrosine-phosphorylated proteins (By similarity). However, not involved in the binding to phosphorylated BCAR1 (By similarity). Required for cell cycle progression in response to INS/insulin (By similarity). Required for regulation of EGF-induced DNA synthesis (By similarity).
messages: The guanine nucleotide exchange factor (GEF) activity is controversial. One study showed GEF activity towards RALA, RAP1A and RRAS (By similarity). However, in another study, a construct containing only the Ras-GEF domain lacks GEF activity towards RAP1 (By similarity).
messages: focal adhesion

10116:Eef2
gene id: 10116:Eef2
uniprot id: P05197
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Binds to 80S ribosomes. Actively translating ribosomes show mutually exclusive binding of eIF5a (EIF5A or EIF5A2) and EEF2/eEF2. Interacts with SERBP1; interaction sequesters EEF2/eEF2 at the A-site of the ribosome, thereby blocking the interaction sites of the mRNA-tRNA complex, promoting ribosome stabilization and hibernation (By similarity). Interacts with HABP4; interaction takes place at the A-site of hibernating ribosomes and promotes ribosome stabilization (By similarity). Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9. Interacts with RBPMS2 (By similarity).
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm
messages: Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine.
messages: ISGylated.
messages: Nucleus
messages: Phosphorylation by EF-2 kinase completely inactivates EF-2; it requires prior phosphorylation by CDK2 at Ser-595 during mitotic prometaphase. Phosphorylation by CSK promotes SUMOylation, proteolytic cleavage, and nuclear translocation if the C-terminal fragment.
messages: Proteolytically processed at two sites following phosphorylation by CSK.
messages: SUMOylated following phosphorylation by CSK, promotes proteolytic cleavage.

10116:Zdhhc8
gene id: 10116:Zdhhc8
uniprot id: Q2THW6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

10116:Arl5c
gene id: 10116:Arl5c
uniprot id: A6HIP1
uniprot id: D3ZES1
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

10116:Adprhl1
gene id: 10116:Adprhl1
uniprot id: A6IWI7
uniprot id: Q5XIB3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although it belongs to the ADP-ribosylglycohydrolase family, lacks the metal-binding and substrate-binding residues, suggesting that it has no hydrolase activity.
messages: Belongs to the ADP-ribosylglycohydrolase family.
messages: Required for myofibril assembly and outgrowth of the cardiac chambers in the developing heart (By similarity). Appears to be catalytically inactive, showing no activity against O-acetyl-ADP-ribose (By similarity).
messages: sarcomere

10116:Orai3
gene id: 10116:Orai3
uniprot id: B2ZDQ0
uniprot id: Q6AXR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orai family.
messages: Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.
messages: Cell membrane
messages: Interacts with CRACR2A/EFCAB4B.
messages: Membrane

10116:Osbpl3
gene id: 10116:Osbpl3
uniprot id: A0A8I5ZPL4
uniprot id: A0A8I6GM73
uniprot id: A6K0M1
uniprot id: D3ZHZ3
names: Similarity
messages: Belongs to the OSBP family.

10116:Ap3m1
gene id: 10116:Ap3m1
uniprot id: A6KKR5
uniprot id: F7FH36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.

10116:Colec12
gene id: 10116:Colec12
uniprot id: Q4V885
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Highly expressed in lung, spleen, small and large intestine, stomach and brain. Expressed in neonatal microglia.
messages: Membrane
messages: Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR) (By similarity).
messages: The extracellular domain forms a stable trimer. The extracellular domain interacts with fibrillar amyloid-beta peptide (By similarity).

10116:Olr1115
gene id: 10116:Olr1115
uniprot id: D4ACI0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Mid1ip1
gene id: 10116:Mid1ip1
uniprot id: A7BKC9
uniprot id: Q6P7D5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Homodimer in the absence of THRSP. Heterodimer with THRSP. The homodimer interacts with ACACA and ACACB. Promotes polymerization of Acetyl-CoA carboxylase to form complexes that contain MID1IP1 and ACACA and/or ACACB. Interaction with THRSP interferes with ACACA binding (By similarity).
messages: It is uncertain whether Met-1 or Met-2 is the initiator.
messages: Nucleus
messages: Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity).
messages: cytoskeleton

10116:Ap1b1
gene id: 10116:Ap1b1
uniprot id: A0A0G2K2V2
uniprot id: A6IKJ5
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

10116:Dkk4
gene id: 10116:Dkk4
uniprot id: A6IW64
uniprot id: D4ADQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

10116:Myoc
gene id: 10116:Myoc
uniprot id: Q9R1J4
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell projection
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Glycosylated.
messages: Golgi apparatus
messages: Highly expressed in skeletal muscle and retina. Also detected at lower levels in thyroid gland but not in other endocrine glands such as the adrenal or pituitary glands.
messages: Homodimer (via N-terminus). Can also form higher oligomers. Interacts with OLFM3, FN1, NRCAM, GLDN and NFASC. Interacts (via N-terminus) with MYL2. Interacts with SFRP1, FRZB, FZD7, FZD10, FZD1 and WIF1; regulates Wnt signaling (By similarity). Interacts with SNTA1; regulates muscle hypertrophy. Interacts with ERBB2 and ERBB3; activates ERBB2-ERBB3 signaling pathway. Interacts with SNCG; affects its secretion and its aggregation (By similarity).
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: Mitochondrion outer membrane
messages: Palmitoylated.
messages: Rough endoplasmic reticulum
messages: Secreted
messages: Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.
messages: Undergoes a calcium-dependent proteolytic cleavage at Gln-225 by CAPN2 in the endoplasmic reticulum. The result is the production of two fragments, one of 35 kDa containing the C-terminal olfactomedin-like domain, and another of 20 kDa containing the N-terminal leucine zipper-like domain (By similarity).
messages: Up-regulated by dexamethasone.
messages: cilium
messages: extracellular exosome
messages: extracellular matrix
messages: extracellular space

10116:Sf3a3
gene id: 10116:Sf3a3
uniprot id: Q4KLI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3A3 family.
messages: Nucleus

10116:B3gnt7
gene id: 10116:B3gnt7
uniprot id: Q66H69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: N-acetyl glucosamine (GlcNAc) transferase that catalyzes the transfer of GlcNAc via a beta1->3 linkage from UDP-GlcNAc to the non-reducing terminal galactose (Gal) in the linearly growing chain of N-and O-linked keratan sulfate proteoglycans. Cooperates with B4GALT4 galactosyltransferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer (By similarity). Involved in biosynthesis of N-linked keratan sulfate proteoglycans in cornea, with an impact on proteoglycan fibril organization and corneal transparency (By similarity). May play a role in the maintenance of tissue architecture by suppressing cellular motility and invasion (By similarity).

10116:Or10a3
gene id: 10116:Or10a3
uniprot id: A6I7U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tmem19
gene id: 10116:Tmem19
uniprot id: A0A0G2K7B8
uniprot id: A0A0H2UHC5
uniprot id: A6IGK7
uniprot id: Q6P726
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

10116:Lrrtm4
gene id: 10116:Lrrtm4
uniprot id: B4F7C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the LRRTM family.
messages: Cell membrane
messages: Expressed in the brain (at protein level).
messages: May play a role in the development and maintenance of the nervous system (By similarity). Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation.
messages: Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including LRRTM4. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing.
messages: Postsynaptic cell membrane

10116:Slc22a17
gene id: 10116:Slc22a17
uniprot id: Q9P290
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Cell membrane
messages: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
messages: Expressed in brain.
messages: Vacuole membrane
messages: Was originally (Ref.1) thought to originate from human.

10116:Or5b102
gene id: 10116:Or5b102
uniprot id: A0A8I5Y7J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Mtx1
gene id: 10116:Mtx1
uniprot id: B0BN02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

10116:Calml3
gene id: 10116:Calml3
uniprot id: Q5U206
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the calmodulin family.
messages: Binds four calcium ions.
messages: Interacts with MYO10, the interaction is calcium-dependent and essential for MYO10 function in filopodial extension.
messages: May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates (By similarity).

10116:Hars2
gene id: 10116:Hars2
uniprot id: A0A8I5ZM00
uniprot id: F1M9C9
uniprot id: Q5EB72
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

10116:Alas1
gene id: 10116:Alas1
uniprot id: A6I2Q2
uniprot id: P13195
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products.
messages: Down-regulated by hemin in the liver and by 6-amino-levulinate (or its methyl ester) in the liver, kidney, heart, testis and brain.
messages: Expressed in the liver, kidney, brain and testis.
messages: Homodimer (By similarity). Interacts (hydroxylated form) with VHL (By similarity).
messages: In normoxia, is hydroxylated at Pro-578, promoting interaction with VHL, initiating ubiquitination and subsequent degradation via the proteasome.
messages: Mitochondrion inner membrane
messages: Ubiquitinated; in normoxia following hydroxylation and interaction with VHL, leading to its subsequent degradation via the proteasome.

10116:LOC100134871
gene id: 10116:LOC100134871
uniprot id: A0A1K0FUA6
uniprot id: A0A1K0GGD1
uniprot id: P11517
names: Function
names: Polymorphism
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: In rats there are two non-allelic alpha chains and two non-allelic beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.

10116:Trmo
gene id: 10116:Trmo
uniprot id: A6IJB7
uniprot id: Q4V7E0
names: Function
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.
messages: S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA.

10116:Lilrb2
gene id: 10116:Lilrb2
uniprot id: D3ZQX2
names: Domain
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
messages: Expression detected in neutrophilic granulocytes.

10116:Gja8
gene id: 10116:Gja8
uniprot id: B1PL10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

10116:Slc25a15
gene id: 10116:Slc25a15
uniprot id: A0A0G2K309
uniprot id: Q7TPA1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Expressed in the liver (at protein level).
messages: Inhibited by pyridoxal 5'-phosphate as well as by mercurials (mersalyl, p-chloromercuribenzene sulfonate, and mercuric chloride), N-ethylmaleimide and spermine.
messages: Membrane
messages: Mitochondrial ornithine-citrulline antiporter. Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Plays a crucial role in the urea cycle, by connecting the cytosolic and the intramitochondrial reactions of the urea cycle (PubMed:9359400, PubMed:10417335). Lysine and arginine are also transported by the antiport mechanism (By similarity). In addition, catalyzes an electroneutral exchange of ornithine or lysine for H(+), a reaction driven by the pH gradient across the inner membrane (PubMed:10417335).
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

10116:Il18r1
gene id: 10116:Il18r1
uniprot id: A0A8I6A1C2
uniprot id: A6INN8
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

10116:Slc22a1
gene id: 10116:Slc22a1
uniprot id: Q63089
names: Activity Regulation
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A large substrate binding region with partially overlapping binding domains for structurally different substrates is formed by several transmembrane helix domains (TMH) including TMH 2, 4, 10 and 11, and it is alternatingly exposed to the extracellular or intracellular side during substrate transport.
messages: Apical cell membrane
messages: Basal cell membrane
messages: Basolateral cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Cell membrane
messages: Cellular localization of OCT1 in the intestine and the kidney remains to be finally defined. While most authors have deduced a localization at the basolateral side of enterocytes consistent with a physiological role in organic anions uptake from the blood flow and intestinal excretion (By similarity), other studies demonstrated an apical localization (By similarity), supporting a function in intestinal absorption of organic anions and drugs (By similarity). Similarly, contradictory findings have shown a localization to the basolateral side (PubMed:7990927, PubMed:9808712, PubMed:10997918, PubMed:11083459) or to the apical side (By similarity) of proximal tubules (PubMed:7990927, PubMed:9808712, PubMed:10997918, PubMed:11083459) (By similarity). Affinity and capacity of the transporter for endogenous substrates vary among orthologs (By similarity).
messages: Contains one proline-rich sequence (Pro-Glu-Ser-Pro-Arg) that is required for transport activity.
messages: Down-regulated in obstructive cholestasis. Up-regulated by treatment with pregnenolone-16 alpha-carbonitrile (PCN) and by overexpression of pregnane X receptor (PXR).
messages: Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:7990927, PubMed:8955087, PubMed:10570053, PubMed:10997918, PubMed:10864577, PubMed:11502595, PubMed:11408531, PubMed:12395288, PubMed:16142924, PubMed:15640376, PubMed:16272756, PubMed:15662044, PubMed:16581093, PubMed:17567940). Functions as a pH- and Na(+)-independent, bidirectional transporter (PubMed:8955087, PubMed:16142924). Cation cellular uptake or release is driven by the electrochemical potential (i.e. membrane potential and concentration gradient) and substrate selectivity (PubMed:8955087, PubMed:9405386, PubMed:16142924, PubMed:17567940). Hydrophobicity is a major requirement for recognition in polyvalent substrates and inhibitors (By similarity). Primarily expressed in the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds from the blood by hepatic and renal clearance (PubMed:7990927, PubMed:9703985, PubMed:10997918). Most likely functions as an uptake carrier in enterocytes contributing to the intestinal excretion and elimination of organic cations from the systemic circulation (By similarity). Transports endogenous monoamines such as N-1-methylnicotinamide (NMN), guanidine, neurotransmitters dopamine, serotonin, noradrenaline, adrenaline and histamine, and quaternary ammonium compound such as choline (PubMed:8955087, PubMed:9776363, PubMed:10570053, PubMed:11502595, PubMed:11408531, PubMed:11758759, PubMed:15662044, PubMed:16581093, PubMed:17567940). Also transports natural polyamines such as spermidine, agmatine and putrescine at low affinity, but relatively high turnover (By similarity). Involved in the hepatic uptake of vitamin B1/thiamine, hence regulating hepatic lipid and energy metabolism (By similarity). Contributes to the influx and efflux of fatty acid carriers carnitines and acylcarnitines acros…
messages: Expressed in kidney cortex and medulla (PubMed:9195965). Expressed in intestine, liver and colon (PubMed:9195965).
messages: Expressed in kidney cortex in S1, S2 segments of renal proximal tubules as well as in kidney medulla (PubMed:7990927, PubMed:9195965, PubMed:9830022, PubMed:9808712, PubMed:10997918, PubMed:11083459, PubMed:11758759, PubMed:11792693, PubMed:16272756). Expressed throughout the liver lobuli, in hepatocytes surrounding the central veins (PubMed:7990927, PubMed:9195965, PubMed:9703985, PubMed:9830022, PubMed:16272756). Expressed in enterocytes of villi and crypts in small intestine (PubMed:7990927, PubMed:9195965, PubMed:9830022). Expressed in brain, in some white matter regions like the corpus callosum and in the granular layer of the cerebellum (PubMed:11792693, PubMed:16581093). Expressed in Sertoli cells in testis (PubMed:17616214). Expressed in colon (PubMed:7990927, PubMed:9195965). Expressed in tracheal and bronchial ciliated epithelium in the respiratory tract (PubMed:15817714). Expressed in spleen, moderately in skin, and weakly in the gastrointestinal tract, lung, thymus, muscle, and prostate (PubMed:11792693).
messages: Functional isoform capable of transporting TEA.
messages: Involved in the uptake of clinically used drugs including diabete treatment medicine metformin, neurotoxins 1-methyl-4-phenylpyridinium (MPP(+)) and iobenguane and platinum-based drug cisplatin (PubMed:8955087, PubMed:9776363, PubMed:10570053, PubMed:12395288, PubMed:16142924, PubMed:15640376, PubMed:16272756, PubMed:15662044, PubMed:16581093, PubMed:17567940). Metformin competitively inhibits OCT1-mediated thiamine uptake, leading to a decrease in hepatic steatosis (By similarity). Plays a role in the anticancer activity of cisplatin and may contribute to antitumor specificity (By similarity).
messages: Lateral cell membrane
messages: Phosphorylated.
messages: Phosphorylation of the transporter leads to changes in its substrate affinity, resulting in a regulation of the transport activity (PubMed:10864577). In contrast with human ortholog, ASP uptake is stimulated by protein kinase A (PKA) and C (PKC) and endogenous tyrosine kinase activation (PubMed:10864577). ASP affinity is induced by PKC-dependent phosphorylation (PubMed:10864577). Inhibited by cGMP, most likely through a cGMP-binding protein that interacts with OCT1 (PubMed:12395288).
messages: Renal level increases gradually from postnatal day 1 through day 45 in both genders.

10116:Mettl24
gene id: 10116:Mettl24
uniprot id: Q5BK01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily.
messages: Probable methyltransferase.
messages: Secreted

10116:Slc1a4
gene id: 10116:Slc1a4
uniprot id: A6JQ21
uniprot id: F7F9N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

10116:Nt5dc2
gene id: 10116:Nt5dc2
uniprot id: Q6Q0N3
names: Similarity
names: Tissue Specificity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Expressed in eye iridocorneal angle.

10116:Hmgn2
gene id: 10116:Hmgn2
uniprot id: A6ISZ1
uniprot id: Q4KLJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

10116:Kif26b
gene id: 10116:Kif26b
uniprot id: D4ADC4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

10116:Or5h27b
gene id: 10116:Or5h27b
uniprot id: D4AAE0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Gja6
gene id: 10116:Gja6
uniprot id: A0A654ID76
uniprot id: P28233
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Expressed in testis.
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

10116:Rabac1
gene id: 10116:Rabac1
uniprot id: A6J929
uniprot id: O35394
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PRA1 family.
messages: Cell membrane
messages: Cytoplasm
messages: General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI1.
messages: Golgi apparatus
messages: Homodimers (By similarity). Interacts specifically with both prenylated Rab proteins (including RAB3A and RAB1), and VAMP2 (synaptobrevin-2), in an exclusive way. Interacts with NDRG1 (By similarity). Interacts with free GDI1 in the absence of Rab proteins. Also interacts with PCLO.
messages: In contrast to the mouse ortholog, it does not interact with the Ras-like GTPases RAC1 and RHOA.
messages: Membrane
messages: Ubiquitous.
messages: synaptic vesicle

10116:Stx5
gene id: 10116:Stx5
uniprot id: A6HZT3
uniprot id: Q08851
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the syntaxin family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Expressed in the brain, heart, spleen, lung, liver, kidney and testis.
messages: Golgi apparatus membrane
messages: Mediates endoplasmic reticulum to Golgi transport (PubMed:10930451, PubMed:14742712, PubMed:9506515). Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus (PubMed:18167358).
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP (PubMed:9506515). Part of a unique SNARE complex composed of the Golgi SNAREs GOSR1, GOSR2 and YKT6. This complex also includes VTI1A (By similarity). Interacts with COG4 (By similarity). Interacts with GM130/GOLGA2 (PubMed:18167358). Interacts (via IxM motif) with SEC24C and SEC24D; mediates STX5 packaging into COPII-coated vesicles (By similarity). Interacts with VLDLR; this interaction mediates VLDLR translocation from the endoplasmic reticulum to the plasma membrane (By similarity).
messages: Produced by alternative initiation at Met-55 of isoform 1.

10116:Dcdc2
gene id: 10116:Dcdc2
uniprot id: D3ZR10
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in hair cells of the inner ear.
messages: Interacts with DVL1, DVL2 and DVL3.
messages: Protein that plays a role in the inhibition of canonical Wnt signaling pathway (By similarity). May be involved in neuronal migration during development of the cerebral neocortex (PubMed:16278297). Involved in the control of ciliogenesis and ciliary length (By similarity).
messages: cilium
messages: cilium axoneme
messages: cytoskeleton
messages: kinocilium

10116:Myh7
gene id: 10116:Myh7
uniprot id: A6KGY1
uniprot id: G3V8B0
uniprot id: P02564
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with ECPAS. Interacts (via C-terminus) with LRRC39.
messages: Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-7 (MYO7).
messages: The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. Four skip residues (Skip1: Thr-1188, Skip2: Glu-1385, Skip3: Glu-1582 and Skip4: Gly-1807) introduce discontinuities in the coiled-coil heptad repeats. The first three skip residues are structurally comparable and induce a unique local relaxation of the coiled-coil superhelical pitch and the fourth skip residue lies within a highly flexible molecular hinge that is necessary for myosin incorporation in the bare zone of sarcomeres (PubMed:26150528).
messages: myofibril
messages: sarcomere

10116:Ncor1
gene id: 10116:Ncor1
uniprot id: A0A0G2K2B4
names: Similarity
messages: Belongs to the N-CoR nuclear receptor corepressors family.

10116:Ptpn2
gene id: 10116:Ptpn2
uniprot id: A0A8I6AMA6
uniprot id: P35233
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Does not show tissue- or cell-type specificity although levels of transcription show variability. Macrophages showed higher levels of expression than lymphocytes.
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Interacts with RMDN3. Interacts with TMED9. Interacts with STX17; dephosphorylates STX17. Interacts with ITGA1 (via cytoplasmic domain); activates the phosphatase activity towards EGFR. Interacts with TRAF2; probably involved in tumor necrosis factor-mediated signaling. Interacts with MET (By similarity).
messages: Minor.
messages: Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogene…
messages: Nucleus
messages: Nucleus membrane
messages: Specifically phosphorylated in a cell cycle-dependent manner by cyclin-dependent kinases CDK1 and CDK2. Probably activated through phosphorylation by PKR.

10116:Tead2
gene id: 10116:Tead2
uniprot id: A6JAZ6
uniprot id: F7FJJ2
names: Subcellular Location Annotation
messages: Nucleus

10116:Or2ag18
gene id: 10116:Or2ag18
uniprot id: A6I7P6
uniprot id: D3ZFV2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Tll1
gene id: 10116:Tll1
uniprot id: A6KFP6
uniprot id: D3Z8U5
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Zdhhc6
gene id: 10116:Zdhhc6
uniprot id: A0A8I5ZNT0
uniprot id: Q32PY5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

10116:MGC105567
gene id: 10116:MGC105567
uniprot id: Q566C9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

10116:LOC100361139
gene id: 10116:LOC100361139
uniprot id: A0A0G2K7A1
uniprot id: A6KT42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

10116:Gli3
gene id: 10116:Gli3
uniprot id: A6K9B6
uniprot id: F1M9H1
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

10116:Mmp27
gene id: 10116:Mmp27
uniprot id: A6JN37
names: Similarity
messages: Belongs to the peptidase M10A family.

10116:Rhebl1
gene id: 10116:Rhebl1
uniprot id: Q7TNZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rheb family.
messages: Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2 (By similarity).
messages: Cytoplasm
messages: Endomembrane system
messages: Interacts with MTOR.

10116:Ribc1
gene id: 10116:Ribc1
uniprot id: A6KLB1
uniprot id: Q6AYL4
names: Similarity
messages: Belongs to the RIB43A family.

10116:Pdyn
gene id: 10116:Pdyn
uniprot id: F1M7S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin.
messages: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Leumorphin has a typical opioid activity and may have anti-apoptotic effect.
messages: Secreted

10116:Or2y11
gene id: 10116:Or2y11
uniprot id: D4A2R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Nlrx1
gene id: 10116:Nlrx1
uniprot id: Q5FVQ8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NLRP family.
messages: Homohexamer (By similarity). Interacts with MAVS (By similarity). Interacts with TUFM (By similarity).
messages: Mitochondrion outer membrane
messages: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (By similarity). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner. In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity).
messages: The LRRCT domain mediates homodimerization and LRRNT mediates trimerization of the dimers.

10116:Gucy2e
gene id: 10116:Gucy2e
uniprot id: P51839
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by Ca(2+) (PubMed:11580282). Activated by NCALD in a Ca(2+)-dependent fashion (PubMed:11580282).
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Functions as an olfactory receptor activated by a urine odorant, uroguanylin (PubMed:18178149). Activated as well by the volatile semiochemicals carbon disulfide (CS2) and carbon dioxide (CO2) (By similarity). Has guanylate cyclase activity upon binding of the ligand (PubMed:18178149). Activation of GUCY2D neurons leads to the cGMP-dependent activation of the CNGA3 channels, membrane depolarization and an increase in action potential frequency. Signaling pathways activated by GUCY2D may trigger social behaviors such as acquisition of food preference (By similarity).
messages: In contrast to mouse, guanylin, a urine odorant, does not stimulate GUCY2D.
messages: Interacts (via the catalytic domain) with NCALD.
messages: Specifically expressed in a subpopulation of olfactory sensory neurons (PubMed:7724600). Expressed in the cilia of the olfactory epithelium (PubMed:11580282).
messages: The nomenclature for members of the GUCY2 gene family is not consistent across species. In mice the GUCY2D gene encodes the protein guanylate cyclase 2D specifically expressed in a subpopulation of olfactory sensory neurons. In rat the official name is GUCY2E for guanylate cyclase 2D. In human this gene is a pseudogene.
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: cilium membrane

10116:Slc25a30
gene id: 10116:Slc25a30
uniprot id: Q5PQM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antiporter that transports inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate. The sulfate/sulfate exchange is much higher than the phosphate/phosphate and malate/malate exchanges. The transport affinities is higher for sulfate and thiosulfate than for any other substrate. May catalyze the export of sulfite and thiosulfate (the hydrogen sulfide degradation products) from the mitochondria, thereby modulating the level of the hydrogen sulfide. Also may mediate a very low unidirectional transport of sulfate, phosphate and (S)-malate.
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with VDAC1.
messages: Mitochondrion inner membrane

10116:Acaa2
gene id: 10116:Acaa2
uniprot id: P13437
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Expressed in liver, brown adipose tissue and heart (at protein level).
messages: Homotetramer. Interacts with BNIP3 (By similarity).
messages: In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs (PubMed:16476568). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (By similarity).
messages: Mitochondrion
messages: The 3-oxoacetyl-CoA thiolase activity is inhibited by acetyl-CoA while the acetyl-CoA hydrolase activity is inhibited by acetoacetyl-CoA.
messages: Up-regulated in liver, brown adipose tissue, heart, intestine and kidney by DEHP/bis(2-ethylhexyl)phthalate (at protein level).

10116:Pck2
gene id: 10116:Pck2
uniprot id: B2RYG2
names: Similarity
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Monomer.

10116:Tfdp1
gene id: 10116:Tfdp1
uniprot id: A0A0G2JXN0
uniprot id: A0A8I6GIG6
uniprot id: A6IWH7
uniprot id: A6IWH8
uniprot id: Q4KM53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

10116:Nono
gene id: 10116:Nono
uniprot id: A6IQC0
uniprot id: Q5FVM4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: DNA- and RNA binding protein, involved in several nuclear processes (By similarity). Binds the conventional octamer sequence in double-stranded DNA (By similarity). Also binds single-stranded DNA and RNA at a site independent of the duplex site (By similarity). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (By similarity). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (By similarity). Together with PSPC1, required for the formation of nuclear paraspeckles (By similarity). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (By similarity). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (By similarity). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (By similarity). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (By similarity). NONO is involved in transcriptional regulation (By similarity). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (By similarity). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (PubMed:15860628). Important for the functional organization of GABAergic synapses (By similarity). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (By similarity). Plays a key role during neuronal different…
messages: Monomer and component of the SFPQ-NONO complex, which is probably a heterotetramer of two 52 kDa (NONO) and two 100 kDa (SFPQ) subunits. NONO is a component of spliceosome and U5.4/6 snRNP complexes (By similarity). Interacts with CPNE4 (via VWFA domain) (By similarity). Forms heterodimers with PSPC1; this involves formation of a coiled coil domain by helices from both proteins. Part of complex consisting of SFPQ, NONO and MATR3. Part of a complex consisting of SFPQ, NONO and NR5A1. Part of a complex consisting of SFPQ, NONO and TOP1. Interacts with SPI1 and SPIB. Interacts with RNF43 (By similarity). Interacts with PER1 and PER2 (PubMed:15860628). Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA. Interacts (via second RRM domain) with WASL; the interaction is direct. Component of a multiprotein complex with WASL and SFPQ (By similarity). Interacts with ERCC6 (By similarity). Interacts (via DNA-binding domain) with TET1 (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: nucleolus

10116:Tinag
gene id: 10116:Tinag
uniprot id: A0A9K3Y6P4
uniprot id: Q66HF6
names: Similarity
messages: Belongs to the peptidase C1 family.

10116:Mas1
gene id: 10116:Mas1
uniprot id: P12526
uniprot id: W8W3M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in platelets.
messages: Interacts with AGTR1. Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
messages: Membrane
messages: Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1 (By similarity).

10116:Olr990
gene id: 10116:Olr990
uniprot id: D4AD16
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Hint2
gene id: 10116:Hint2
uniprot id: A6IJ43
names: Similarity
messages: Belongs to the HINT family.

10116:Tpp1
gene id: 10116:Tpp1
uniprot id: Q642E6
uniprot id: Q9EQV6
names: Cofactor
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity (By similarity).
messages: Binds 1 Ca(2+) ion per subunit.
messages: Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.
messages: Lysosome
messages: Melanosome
messages: Monomer. Interacts with CLN5 (By similarity). Interacts with CLN3 (By similarity).

10116:Slc37a2
gene id: 10116:Slc37a2
uniprot id: A0A096MJU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

10116:Rdh8
gene id: 10116:Rdh8
uniprot id: A6JNL6
uniprot id: D4A8D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Membrane
messages: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity.

10116:Cyb5r3
gene id: 10116:Cyb5r3
uniprot id: A6HT85
uniprot id: P20070
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor.
messages: Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MTARC2 (By similarity). Interacts with MTLN; the interaction is required to maintain cellular lipid composition and leads to stimulation of mitochondrial respiratory complex I activity (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Expressed only in erythroid tissues, reticulocytes and liver.
messages: Mitochondrion outer membrane
messages: Myristoylated.
messages: Produced by alternative initiation.
messages: Produced by alternative promoter usage.
messages: Ubiquitously expressed.

10116:Ddx39a
gene id: 10116:Ddx39a
uniprot id: Q5U216
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DECD subfamily.
messages: Binds ALYREF/THOC4 and DDX39B/BAT1 (By similarity). Interacts with SARNP (By similarity). Interacts with MX1 (By similarity). Interacts with MCM3AP (By similarity).
messages: Cytoplasm
messages: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus (By similarity).
messages: Nucleus

10116:Higd1c
gene id: 10116:Higd1c
uniprot id: M0RBN7
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

10116:Selenos
gene id: 10116:Selenos
uniprot id: Q8VHV8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenoprotein S family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Interacts with DERL1 and (via VIM motif) with VCP, suggesting that it forms a membrane complex with DERL1 that serves as a receptor for VCP. Also interacts with DERL2, DERL3 and SELENOK. The SELENOK-SELENOS complex interacts with VCP (By similarity). Interacts with CCDC47 (By similarity).
messages: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination (By similarity).
messages: Truncated SELENOS proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC2) and CRL2(KLHDC3) complexes, which recognizes the glycine (Gly) at the C-terminus of truncated SELENOS proteins. Truncated SELENOS proteins produced by failed UGA/Sec decoding are also ubiquitinated by the CRL5(KLHDC1) complex.

10116:Dync1i2
gene id: 10116:Dync1i2
uniprot id: A6HM43
uniprot id: A6HM44
uniprot id: A6HM45
uniprot id: D3ZU74
uniprot id: F7FJ03
uniprot id: G3V9V3
names: Similarity
messages: Belongs to the dynein intermediate chain family.

10116:Olr1090
gene id: 10116:Olr1090
uniprot id: A0A8I6B239
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Add2
gene id: 10116:Add2
uniprot id: A6IAV2
uniprot id: F8WFS9
uniprot id: Q05764
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Cell membrane
messages: Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.
messages: Found in liver, kidney, spleen, heart and brain.
messages: Heterodimer of an alpha and a beta subunit. Found in a complex with ADD2, DMTN and SLC2A1. Interacts with SLC2A1 (By similarity).
messages: Membrane
messages: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity).
messages: cytoskeleton

10116:Gtf2e1
gene id: 10116:Gtf2e1
uniprot id: A6IR94
uniprot id: G3V992
names: Function
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

10116:Isy1
gene id: 10116:Isy1
uniprot id: A6IB20
uniprot id: Q6AYB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ISY1 family.
messages: Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (By similarity). By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes transition to the primed state (By similarity). Involved in pre-mRNA splicing as component of the spliceosome.
messages: Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE. Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex. The IB complex does not contain PRPF19. Interacts with CPSF3; this interaction is in an RNA independent manner (By similarity). Interacts with the microprocessor complex subunits DGCR8 and DROSHA; this interaction is in an RNA dependent manner (By similarity).
messages: Nucleus

10116:Sult1a1
gene id: 10116:Sult1a1
uniprot id: A6I9A5
uniprot id: P17988
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sulfotransferase 1 family.
messages: Cytoplasm
messages: Homodimer.
messages: Induced by androgens and suppressed by estrogens. The expression is under the influence of pituitary growth hormone and thyroid hormone.
messages: Liver, kidney, heart and colon.
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds (PubMed:8447833, PubMed:7889867, PubMed:1513323). Plays an important roles in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin (By similarity). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (PubMed:1513323). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
messages: The N-terminus is blocked.

10116:Or4f57
gene id: 10116:Or4f57
uniprot id: D3ZL13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Hsbp1
gene id: 10116:Hsbp1
uniprot id: A6IZI3
uniprot id: Q8K3X8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HSBP1 family.
messages: Homohexamer. Associates with heptad repeats of HSF1 trimers and probably also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer (By similarity).
messages: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity).
messages: Nucleus

10116:Or51v8
gene id: 10116:Or51v8
uniprot id: D3ZJB3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Or11a4
gene id: 10116:Or11a4
uniprot id: Q6MFX1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Sema4d
gene id: 10116:Sema4d
uniprot id: A0A8I6G5Q1
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Gbp2
gene id: 10116:Gbp2
uniprot id: A0A9K3Y7W5
uniprot id: Q5PQW8
uniprot id: Q63663
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
messages: By IFNG.
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Homodimer; homodimerization occurs upon GTP-binding and is required for the association with membranous structures. Heterodimer with other family members, including GBP1, GBP3, GBP4 and GBP5.
messages: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (By similarity). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol. Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome. Confers protection to the protozoan pathogen Toxoplasma gondii (By similarity). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity by inhibiting FURIN-mediated maturation of viral envelope proteins (By similarity).
messages: Isoprenylation is required for proper subcellular location.
messages: Widely expressed.
messages: perinuclear region

10116:Eaf2
gene id: 10116:Eaf2
uniprot id: A6IRB1
uniprot id: Q811X5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional transactivator of ELL, ELL2 and TCEA1 elongation activities (By similarity). Potent inducer of apoptosis in prostatic and non-prostatic cell lines.
messages: Belongs to the EAF family.
messages: Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with ELL, ELL2 and TCEA1 (By similarity).
messages: Nucleus speckle

10116:Fes
gene id: 10116:Fes
uniprot id: A6JCB2
uniprot id: D4A584
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton

10116:Or2ag1
gene id: 10116:Or2ag1
uniprot id: A6I7Q0
uniprot id: D3ZRU1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Wnt9b
gene id: 10116:Wnt9b
uniprot id: A6HJT0
uniprot id: D3ZFS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

10116:Or2d4
gene id: 10116:Or2d4
uniprot id: A6I7Q4
uniprot id: D4ABA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Krt31
gene id: 10116:Krt31
uniprot id: Q6IFV8
names: Similarity
messages: Belongs to the intermediate filament family.

10116:Tpi1
gene id: 10116:Tpi1
uniprot id: P48500
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
messages: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

10116:Axin2
gene id: 10116:Axin2
uniprot id: O70240
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway.
messages: Cytoplasm
messages: Expressed in lung and thymus.
messages: Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
messages: Interacts with SMAD7 and RNF111. Interacts with ANKRD6 (By similarity). Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin (PubMed:9566905). The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin (PubMed:9566905). Interacts with SIAH1 (By similarity). Interacts with SIAH2 (By similarity).
messages: Probably phosphorylated by GSK3B and dephosphorylated by PP2A.
messages: The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2.
messages: Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.

10116:Ptges
gene id: 10116:Ptges
uniprot id: Q9JHF3
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Activity is increased following LPS stimulation and down-regulated by the anti-inflammatory glucocorticoid dexamethasone.
messages: Belongs to the MAPEG family.
messages: Membrane
messages: Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:10869354, PubMed:11067848). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity).
messages: Up-regulated after treatment with LPS or in a rat model of adjuvant-induced arthritis (PubMed:10869354, PubMed:11067848). Down-regulated by the anti-inflammatory glucocorticoid dexamethasone (PubMed:10869354).
messages: perinuclear region

10116:Pcmtd1
gene id: 10116:Pcmtd1
uniprot id: A6JFH4
uniprot id: D4A629
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

10116:Tas2r120
gene id: 10116:Tas2r120
uniprot id: Q67ET3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Putative taste receptor which may play a role in the perception of bitterness.
messages: Several bitter taste receptors are expressed in a single taste receptor cell.

10116:Rps28
gene id: 10116:Rps28
uniprot id: A6KQI3
uniprot id: P62859
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS28 family.
messages: Component of the 40S small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol
messages: nucleolus

10116:Nfrkb
gene id: 10116:Nfrkb
uniprot id: A6JYG5
uniprot id: D4A421
names: Subcellular Location Annotation
messages: Nucleus

10116:Nhsl2
gene id: 10116:Nhsl2
uniprot id: A0A8I6B629
names: Similarity
messages: Belongs to the NHS family.

10116:Galnt9
gene id: 10116:Galnt9
uniprot id: A6J2A0
uniprot id: D3ZQA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

10116:Pcgf6
gene id: 10116:Pcgf6
uniprot id: Q5XI70
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of a PRC1-like complex. Interacts with BMI1/PCGF4, RING1 and RNF2. Interacts with KDM5D. Interacts with CBX4, CBX6, CBX7 and CBX8.
messages: Nucleus
messages: Phosphorylated during mitosis.
messages: Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.

10116:Npl
gene id: 10116:Npl
uniprot id: Q66H59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.
messages: Cytoplasm
messages: Homotetramer.

10116:Tdrd7
gene id: 10116:Tdrd7
uniprot id: A0A8L2R3M8
uniprot id: A6IJA7
uniprot id: Q9R1R4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TDRD7 family.
messages: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis (By similarity).
messages: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.
messages: Cytoplasm
messages: Expressed in brain and testis.
messages: Expressed in embryo at 16 dpc onwards.
messages: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1 (By similarity).
messages: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1.

10116:Or5b12
gene id: 10116:Or5b12
uniprot id: A0A0G2K3N7
uniprot id: A6I0F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Dram1
gene id: 10116:Dram1
uniprot id: B5DEF4
names: Subcellular Location Annotation
messages: Membrane

10116:Spag11bl
gene id: 10116:Spag11bl
uniprot id: Q30KJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Secreted

10116:Olr1349
gene id: 10116:Olr1349
uniprot id: A0A8I5ZK43
uniprot id: A6JQU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Sfxn2
gene id: 10116:Sfxn2
uniprot id: G3V8N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

10116:Lsm3
gene id: 10116:Lsm3
uniprot id: A6IBA3
uniprot id: D4A7U6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

10116:Apoa4
gene id: 10116:Apoa4
uniprot id: P02651
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the apolipoprotein A1/A4/E family.
messages: Homodimer.
messages: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
messages: Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.
messages: Secreted
messages: Secreted in plasma.

10116:Kcna3
gene id: 10116:Kcna3
uniprot id: A6HUR8
uniprot id: P15384
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily.
messages: Cell membrane
messages: Heterotetramer of potassium channel proteins (By similarity). Binds PDZ domains of DLG1, DLG2 and DLG4.
messages: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
messages: Membrane
messages: N-glycosylation promotes the cell surface expression.
messages: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

10116:Nthl1
gene id: 10116:Nthl1
uniprot id: A6HCU4
uniprot id: D4A4E8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Interacts with YBX1.
messages: Mitochondrion
messages: Nucleus

10116:Glipr1
gene id: 10116:Glipr1
uniprot id: A6IGI2
uniprot id: F7EQZ0
names: Similarity
messages: Belongs to the CRISP family.

10116:Cep170b
gene id: 10116:Cep170b
uniprot id: D4A1G8
names: Similarity
messages: Belongs to the CEP170 family.

10116:Ndufa9
gene id: 10116:Ndufa9
uniprot id: Q5BK63
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Acetylated on lysine residues. BLOC1S1 is required for acetylation. Acetylated by CLOCK in a circadian manner.
messages: Belongs to the complex I NDUFA9 subunit family.
messages: Binds 1 FAD per subunit.
messages: Complex I is composed of 45 different subunits (By similarity). This a component of the hydrophobic protein fraction (By similarity). Interacts with BLOC1S1 (By similarity). Interacts with SLC2A4 (PubMed:16396496). Interacts with CLOCK (By similarity). Interacts with RAB5IF (By similarity).
messages: Expressed by the principal cells of the epididymis. Detected in flagella of epididymal sperm (at protein level).
messages: Mitochondrion matrix

10116:Bud13
gene id: 10116:Bud13
uniprot id: Q4QQU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC26 family.
messages: Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).
messages: Nucleus
messages: Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed of at least 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Component of the minor spliceosome, which splices U12-type introns (By similarity).

10116:S100a10
gene id: 10116:S100a10
uniprot id: P05943
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
messages: Belongs to the S-100 family.
messages: By nerve growth factor.
messages: Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.
messages: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36 (By similarity). Interacts with SCN10A (PubMed:12050667). Interacts with TASOR (By similarity).

10116:Spata6
gene id: 10116:Spata6
uniprot id: A6JZ10
uniprot id: B0BMV7
names: Similarity
messages: Belongs to the SPATA6 family.

10116:Olr621
gene id: 10116:Olr621
uniprot id: A0A8I6AE40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Or1j22
gene id: 10116:Or1j22
uniprot id: A0A8I6GEF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Olr1218
gene id: 10116:Olr1218
uniprot id: M0RCI3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Olr995
gene id: 10116:Olr995
uniprot id: A0A8I6AHR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Hdac5
gene id: 10116:Hdac5
uniprot id: A6HJH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

10116:Ints3
gene id: 10116:Ints3
uniprot id: D3ZUT9
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

10116:Cox8c
gene id: 10116:Cox8c
uniprot id: A6JEL8
uniprot id: Q7TNN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

10116:Adgrb1
gene id: 10116:Adgrb1
uniprot id: C0HL12
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Inhibits angiogenesis in a CD36-dependent manner.
messages: Inhibits angiogenesis.
messages: Interacts with ELMO1 and DOCK1 (By similarity). When bound to ELMO1 and DOCK1, acts as a module to promote apoptotic cell engulfment (By similarity). Interacts with MDM2; the interaction results in inhibition of MDM2-mediated ubiquitination and degradation of DLG4/PSD95 (By similarity). Interacts with PARD3 and TIAM1; the interaction is required for correct dendritic localization of PARD3 and TIAM1 and for dendritic spine formation (PubMed:23595754). Interacts with MAGI1, MAGI3 and BAIAP2 (By similarity). Interacts with PHYHIP (By similarity). Interacts with DLG4 (via PDZ domain) (By similarity). Vasculostatin-120: Interacts with CD36 (By similarity). Vasculostatin-120: Interacts with ARRB2 (By similarity). Interacts with BAIAP3; this interaction is direct (By similarity).
messages: Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (By similarity). Also mediates the binding and engulfment of Gram-negative bacteria (By similarity). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (By similarity). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (By similarity). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (By similarity). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct dendritic localization of PARD3 and TIAM1 (PubMed:23595754). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (By similarity).
messages: Postsynaptic density
messages: Proteolytically cleaved to produce vasculostatin-40 and vasculostatin-120. Vasculostatin-40 is the major form and is produced through proteolytic cleavage by MMP14 between residues 317 and 325 with cleavage likely to be between Ser-322 and Leu-323.
messages: Secreted
messages: The TSP type-1 repeats in the extracellular domain mediate binding to phosphatidylserine. They are also required for bacterial recognition and binding to bacterial outer membrane lipopolysaccharide.
messages: Ubiquitinated.
messages: dendritic spine
messages: focal adhesion
messages: phagocytic cup

10116:Or2v2c
gene id: 10116:Or2v2c
uniprot id: A0A8I6A8P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Lss
gene id: 10116:Lss
uniprot id: P48450
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the terpene cyclase/mutase family.
messages: Endoplasmic reticulum membrane
messages: Hypomorphic mutations in this gene and the Fdft1 gene were identified, as well as a null mutation in this gene. Cataract onset is associated with the specific combination of Lss and Fdft1 mutant alleles that decrease cholesterol levels in cataractous lenses to about 57% of normal. Cholesterol insufficiency may cause the deficient proliferation of lens epithelial cells in Shumiya cataract rats, resulting in the loss of homeostatic epithelial cell control of the underlying fiber cells and ultimately cataractogenesis.
messages: Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (PubMed:7568116). Through the production of lanosterol may regulate lens protein aggregation and increase transparency (By similarity).
messages: Monomer.

10116:RGD1309350
gene id: 10116:RGD1309350
uniprot id: A6HXJ9
uniprot id: D3ZCS9
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Homotetramer.

10116:Cnr1
gene id: 10116:Cnr1
uniprot id: A6IIL9
uniprot id: P20272
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in the brain, in the striatum, medial septum, descending arm of the band of Broca, the amygdaloid nucleus, the hippocampus and cortex (at protein level). High levels in the lateral striatum. In rostral brain regions, high expression levels in the dorsal lateral striatum, while in the caudal brain regions, high levels are observed in the ventral lateral striatum (PubMed:2165569, PubMed:10362691, PubMed:10891614, PubMed:16033894). Expressed in monocytes/macrophages (at protein level) (PubMed:23955712). Expressed in striated muscles and in vascular smooth muscles cells (at protein level) (PubMed:10362691, PubMed:26671069).
messages: G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG) (PubMed:2165569). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2. In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids, drives the release of orexigenic beta-endorphin, but not that of melanocyte-stimulating hormone alpha/alpha-MSH, from hypothalamic POMC neurons, hence promoting food intake. In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (By similarity). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca(2+) channels in a constitutive, as well as agonist-dependent manner (By similarity)…
messages: G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Signaling typically involves reduction in cyclic AMP.
messages: Hemopressin, a peptide derived from hemoglobin subunit alpha (HBA1 and/or HBA2), acts as an antagonist peptide: hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
messages: High-fat diet also increases the hepatic levels of CNR1 ligand anandamide, but not that of 2-arachidonoylglycerol.
messages: Interacts (via C-terminus) with CNRIP1 (PubMed:17895407). Associates with G protein alpha subunits, including G(i) alpha-1/GNAI1, G(i) alpha-3/GNAI3 and G(o)-alpha/GNAO1; palmitoylation is important for interaction with GNAI3 and GNAO1 (PubMed:21895628).
messages: Interacts (via C-terminus) with CNRIP1.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Palmitoylation at Cys-416 is important for recruitment at both plasma membrane and lipid rafts and association with G protein alpha subunits.
messages: Presynapse
messages: Synapse
messages: axon

10116:Ahsg
gene id: 10116:Ahsg
uniprot id: P24090
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the fetuin family.
messages: Could inhibit both insulin-receptor tyrosine kinase activity and insulin-stimulated receptor autophosphorylation and, concomitantly, antagonize the mitogenic effect of the hormone in cultured rat hepatoma cells.
messages: Phosphorylated by FAM20C in the extracellular medium.
messages: Secreted
messages: Synthesized in liver and secreted by the hepatocytes in the blood.
messages: Undergoes complex post-translational modification involving N-glycosylation, and addition of fucose and sialic acid residues. Phosphorylation occurs at a serine residue.

10116:Cts7
gene id: 10116:Cts7
uniprot id: D3ZZ07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Endosome
messages: Golgi apparatus
messages: Involved in trophoblast cell proliferation and differentiation probably by affecting mitotic cell cycle progression. Proteolytic activity and nuclear localization are essential for its role in cell cycle progression (By similarity).
messages: Lysosome
messages: Nucleus
messages: extracellular space
messages: perinuclear region

10116:Or5b123b
gene id: 10116:Or5b123b
uniprot id: A0A0G2K3R9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Pkm
gene id: 10116:Pkm
uniprot id: A0A8I6ABE3
uniprot id: A6J531
uniprot id: A6J532
uniprot id: P11980
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300, leading to impair phosphoenolpyruvate substrate-binding and promote its homodimerization and subsequent translocation to the nucleus. Deacetylation by SIRT6 promotes its nuclear export into the cytoplasm, leading to suppress its nuclear localization and oncogenic function.
messages: Acetylation at Lys-305 is stimulated by high glucose concentration, it decreases enzyme activity and promotes its lysosomal-dependent degradation via chaperone-mediated autophagy.
messages: Belongs to the pyruvate kinase family.
messages: Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
messages: Cytoplasm
messages: FGFR1-dependent tyrosine phosphorylation is reduced by interaction with TRIM35.
messages: Has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity.
messages: ISGylated.
messages: Isoform M2 is allosterically activated by D-fructose 1,6-bisphosphate (FBP). Inhibited by oxalate and 3,3',5-triiodo-L-thyronine (T3). The activity of the tetrameric form is inhibited by PML. Selective binding to tyrosine-phosphorylated peptides releases the allosteric activator FBP, leading to inhibition of PKM enzymatic activity, this diverts glucose metabolites from energy production to anabolic processes when cells are stimulated by certain growth factors. Glycolytic flux are highly dependent on de novo biosynthesis of serine and glycine, and serine is a natural ligand and allosteric activator of isoform M2.
messages: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity. In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase. Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase. Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription. Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (By similarity). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages. May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (By similarity).
messages: Monomer and homotetramer; exists as a monomer in the absence of D-fructose 1,6-bisphosphate (FBP), and reversibly associates to form a homotetramer in the presence of FBP. The monomeric form binds 3,3',5-triiodo-L-thyronine (T3). Tetramer formation induces pyruvate kinase activity. The tetrameric form has high affinity for the substrate and is associated within the glycolytic enzyme complex. FBP stimulates the formation of tetramers from dimers. Homodimer; exists in a dimeric form in tumor cells and the dimeric form has less affinity for the phosphoenolpyruvate substrate. The homodimer converts into a protein kinase. Interacts with HERC1, POU5F1 and PML. Interacts with EGLN3; the interaction hydroxylates PKM under hypoxia and enhances binding to HIF1A. Interacts with HIF1A; the interaction is enhanced by binding of EGLN3, promoting enhanced transcription activity under hypoxia. Interacts with TRIM35; this interaction prevents FGFR1-dependent tyrosine phosphorylation. Interacts with JMJD8. Interacts with TRAF4. Interacts with (phosphorylated) CTNNB1; leading to activate transcription. Interacts with TSC22D2; the interaction results in reduced nuclear levels of PKM isoform M2, leading to repression of cyclin CCND1 transcription and reduced cell growth (By similarity).
messages: Nucleus
messages: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth. In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity.
messages: There are 4 isozymes of pyruvate kinase in mammals (L, R, M1, M2) encoded by 2 different genes: PKLR and PKM. The L and R isozymes are generated from the PKLR by differential splicing of RNA; the M1 and M2 forms are produced from the PKM gene by differential splicing. L type is major isozyme in the liver, R is found in red cells, M1 is the main form in muscle, heart and brain, and M2 is found in early fetal tissues as well as in most cancer cells.
messages: Under hypoxia, hydroxylated by EGLN3.

10116:Crnkl1
gene id: 10116:Crnkl1
uniprot id: P63155
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the crooked-neck family.
messages: Highly expressed in embryonic brain but its expression decrease during development.
messages: Identified in the spliceosome C complex. Present in a spliceosome complex assembled in vitro containing CRNKL1, HPRP8BP and SNRPB2. Component of the minor spliceosome, which splices U12-type introns (By similarity). Interacts with PPIL2 (via the PPIase cyclophilin-type domain); they may form a trimeric complex with HSP90.
messages: Involved in pre-mRNA splicing process. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
messages: Nucleus
messages: Nucleus speckle

10116:Gpam
gene id: 10116:Gpam
uniprot id: A0A0G2JV22
uniprot id: A6JHY2
uniprot id: P97564
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

10116:Olr1201
gene id: 10116:Olr1201
uniprot id: A6KRJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Clvs1
gene id: 10116:Clvs1
uniprot id: A6JFQ6
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binding to PtdIns(3,5)P2 is not required for localization.
messages: Early endosome membrane
messages: Expressed in brain with no expression detected in non-neuronal tissues (at protein level).
messages: Forms a complex with clathrin heavy chain and gamma-adaptin.
messages: Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
messages: The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2.
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

10116:Ndufv2
gene id: 10116:Ndufv2
uniprot id: A6JRE2
uniprot id: P19234
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme (By similarity).
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Mitochondrion inner membrane

10116:Nrcam
gene id: 10116:Nrcam
uniprot id: A0A0G2JW27
uniprot id: A0A1W5DU98
uniprot id: A0A8J8YHB8
uniprot id: Q6PW34
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

10116:Zfp703
gene id: 10116:Zfp703
uniprot id: A6IVY5
uniprot id: D4ABF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Elbow/Noc family.
messages: Nucleus

10116:Lamtor1
gene id: 10116:Lamtor1
uniprot id: A6I6Y5
uniprot id: Q6P791
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane. LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (By similarity). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation (By similarity).
messages: Late endosome membrane
messages: Lysosome membrane
messages: N-terminal myristoylation and palmitoylation mediates its recruitment to lysosome membranes, thereby promoting localization of the Ragulator complex to lysosomes. N-myristoylation by NMT1 is required for palmitoylation at Cys-3 and Cys-4. May be palmitoylated by ZDHHC3.
messages: Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. Interacts with LAMTOR2 and LAMTOR3; the interaction is direct. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and RagD/RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RagA/RRAGA or RagB/RRAGB GDP-bound, RagC/RRAGC or RagD/RRAGD GTP-bound, and Ragulator. Associates with the lysosomal V-ATPase complex; interaction promotes the guanine nucleotide exchange factor (GEF) of the Ragulator complex. Interacts with MMP14. Interacts with CDKN1B; prevents the interaction of CDKN1B with RHOA leaving RHOA in a form accessible to activation by ARHGEF2. Interacts with PIP4P1.
messages: Ubiquitinated at Lys-60, Lys-103 and Lys-104 by UBE3A, promoting its degradation by the proteasome. Ubiquitination at Lys-20 impairs the association with the lysosomal V-ATPase complex. Deubiquitination at Lys-20 by USP32 promotes the association with the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex.
messages: Ubiquitously expressed.

10116:Olr1280
gene id: 10116:Olr1280
uniprot id: A0A0G2K0H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Chrna1
gene id: 10116:Chrna1
uniprot id: A6HMA1
uniprot id: P25108
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: One of the alpha chains that assemble within the acetylcholine receptor, a pentamer of two alpha chains, a beta, a delta, and a gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII.
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

10116:Or51a7
gene id: 10116:Or51a7
uniprot id: F1LXE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Dynlt3
gene id: 10116:Dynlt3
uniprot id: Q5XI90
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

10116:Arfgef2
gene id: 10116:Arfgef2
uniprot id: Q7TSU1
names: Activity Regulation
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Endosome
messages: Expressed in brain (at protein level).
messages: Golgi apparatus
messages: Homodimer. Interacts with ARFGEF1/BIG1; both proteins are probably part of the same or very similar macromolecular complexes. Interacts with PRKAR1A, PRKAR2A, PRKAR1B, PRKAR2B, PPP1CC, PDE3A, TNFRSF1A, MYCBP and EXOC7 (By similarity). Interacts with GABRB1, GABRB2 and GABRB3.
messages: In vitro phosphorylated by PKA reducing its GEF activity and dephosphorylated by phosphatase PP1.
messages: Inhibited by brefeldin A.
messages: Membrane
messages: Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.
messages: Synapse
messages: centrosome
messages: cytoskeleton
messages: dendrite
messages: perinuclear region
messages: trans-Golgi network

10116:Rangrf
gene id: 10116:Rangrf
uniprot id: A6HFM3
uniprot id: D3ZMP9
names: Similarity
messages: Belongs to the MOG1 family.

10116:Hoxb1
gene id: 10116:Hoxb1
uniprot id: A6HIF3
uniprot id: G3V737
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

10116:Or4c105b
gene id: 10116:Or4c105b
uniprot id: A0A8I6AEV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Smc1b
gene id: 10116:Smc1b
uniprot id: A6HTD3
uniprot id: D3ZE73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

10116:Zfp532
gene id: 10116:Zfp532
uniprot id: A0A8I6A3F9
uniprot id: A6IXQ6
uniprot id: D4A659
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

10116:Shox2
gene id: 10116:Shox2
uniprot id: O35750
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Expression restricted to a few regions in the brain: thalamic, tectal and brainstem structures that include relay nuclei of the visual and auditory systems as well as other ascending systems conveying somatosensory information. Not expressed in kidney, heart, lung, tongue and adrenal gland.
messages: May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.
messages: Neural expression in lateral and medial geniculate complex, superior and inferior colliculus, superficial gray layer of the superior colliculus, pontine reticular formation and inferior olive. Also expressed in non-neuronal structures around the oral cavity and in hip and shoulder regions.
messages: Nucleus

10116:Dnajc25
gene id: 10116:Dnajc25
uniprot id: Q5BJW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAJC25 family.
messages: Membrane

10116:Tmem198b
gene id: 10116:Tmem198b
uniprot id: A6KSI8
uniprot id: D3ZAM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

10116:Cib1
gene id: 10116:Cib1
uniprot id: Q9R010
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also ca…
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in cardiomyocytes and neurons (at protein level). Expressed during early neural development.
messages: Membrane
messages: Monomer. Interacts with the heterodimeric integrin alpha-IIb/beta3 (ITGA2B-ITGB3). Interacts with ITGA2B (via cytoplasmic domain); the interaction is direct and calcium-dependent. Interacts with the protein kinases PLK2/SNK and PRKDC (via the region immediately upstream of the kinase domain). Interacts with PLK3; the interaction inhibits PLK3 kinase activity. Interacts with PSEN2. Interacts (via C-terminus) with F8. Interacts with NBR1 (via C-terminus). Interacts with FEZ1 (via C-terminus). Interacts with UBR5 (via C-terminus); the interaction is sensitive to DNA damage, and may target CIB1 for ubiquitin-mediated degradation. Interacts with IFI6; the interaction is direct. Interacts with BCL2. Interacts with ITPR3; the interaction occurs in a calcium dependent manner. Interacts with PTK2/FAK1. Interacts with MAP3K5; the interaction inhibits MAP3K5 activation by phosphorylation, and its subsequent interaction with TRAF2. Interacts (via C-terminal region) with STMN2 (via the N-terminal region); the interaction is direct, occurs in a calcium-dependent manner and attenuates the STMN2-induced neurite outgrowth inhibition. Interacts with SPHK1, the interaction occurs in a calcium-dependent manner. Interacts with ITGA2B (via C-terminal cytoplasmic tail); the interaction occurs upon platelet aggregation and is stabilized/increased in a calcium and magnesium-dependent manner. Interacts with PAK1 (via N-terminal region); the interaction is direct and occurs in a calcium-dependent manner. Interacts with RAC3 (via C-terminal region); the interaction induces their association with the cytoskeleton upon alpha-IIb/beta3 integrin-mediated adhesion. Interacts with ITGA5 and ITGAV. Interacts with MYO1C. Interacts with ITGA2B (via C-terminal cytoplasmic tail region). Interacts (via C-terminal region) with PPP3R1; the interaction increases upon cardiomyocytes hypertrophy. Interacts with CACNA1C; the interaction increases upon cardiomyocytes hypertrophy (By similarity). Interacts with T…
messages: Nucleus
messages: Perikaryon
messages: The EF-hands may also bind magnesium ions in the presence of high Mg(2+) levels and low Ca(2+) levels.
messages: The binding of either calcium or magnesium significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form).
messages: centrosome
messages: cytoskeleton
messages: filopodium tip
messages: growth cone
messages: lamellipodium
messages: neuron projection
messages: perinuclear region
messages: ruffle membrane
messages: sarcolemma

10116:Spz1
gene id: 10116:Spz1
uniprot id: Q6AXY9
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with PPP1CC isoform gamma-2.
messages: Nucleus
messages: Phosphorylated by MAPK1/ERK2 and MAPK3/ERK1.
messages: The helix-loop-helix and basic motifs form a SPZ1 specific bHLH different from the classical one.
messages: Transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity).

10116:Cdkl1
gene id: 10116:Cdkl1
uniprot id: A6HBX5
uniprot id: Q66HE7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Cytoplasm
messages: Nucleus
messages: The [NKR]KIAxRE motif seems to be a cyclin-binding region.

10116:Olr1471
gene id: 10116:Olr1471
uniprot id: A0A8I6AI34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Hes2
gene id: 10116:Hes2
uniprot id: P35429
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
messages: Nucleus
messages: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
messages: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.
messages: Transcriptional repressor of genes that require a bHLH protein for their transcription.

10116:Rnf146
gene id: 10116:Rnf146
uniprot id: A0A140TAB2
uniprot id: Q5XIK5
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation (By similarity).
messages: Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein (By similarity). Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (By similarity). Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (By similarity). Does not affect PARP1 activation. Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (By similarity). Promotes cell survival after gamma-irradiation. Facilitates DNA repair (By similarity).
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: Nucleus
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: Ubiquitinated; autoubiquitinated. Autoubiquitination is enhanced upon poly(ADP-ribose)-binding (By similarity).
messages: cytosol

10116:Ptbp2
gene id: 10116:Ptbp2
uniprot id: Q66H20
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Monomer. Interacts with NOVA1; the interaction is direct. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Part of a ternary complex containing KHSRP and HNRPH1 (By similarity). Interacts with NOVA2; the interaction is direct (By similarity).
messages: Nucleus
messages: RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation.

10116:Ube2i
gene id: 10116:Ube2i
uniprot id: A6HD16
uniprot id: P63281
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451 (By similarity). Can catalyze the formation of poly-SUMO chains (By similarity). Essential for nuclear architecture and chromosome segregation (By similarity). Necessary for sumoylation of FOXL2 and KAT5 (By similarity). Sumoylates p53/TP53 at 'Lys-386' (By similarity). Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity (By similarity).
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Broadly expressed, with highest levels in spleen and lung (at protein level).
messages: Cytoplasm
messages: Forms a complex with SENP6 and UBE2I in response to UV irradiation (By similarity). Forms a tight complex with RANGAP1 and RANBP2 (By similarity). Identified in a complex with SUMO2 and UBE2I, where one ZNF451 interacts with one UBE2I and two SUMO2 chains, one bound to the UBE2I active site and the other to another region of the same UBE2I molecule (By similarity). Interacts with SETX (By similarity). Interacts with HIPK1 and HIPK2 (By similarity). Interacts with PPM1J (By similarity). Interacts with RASD2 (PubMed:19498170). Interacts with TCF3 (PubMed:9013644). Interacts with NR2C1; the interaction promotes its sumoylation (By similarity). Interacts with SIAH1 (By similarity). Interacts with PARP (By similarity). Interacts with various transcription factors such as TFAP2A, TFAP2B, and TFAP2C (By similarity). Interacts with AR (By similarity). Interacts with ETS1 (By similarity). Interacts with SOX4 (By similarity). Interacts with RWDD3; the interaction enhances the sumoylation of a number of proteins such as HIF1A and I-kappa-B (By similarity). Interacts with FOXL2 (By similarity). Interacts with DNM1l (via its GTPase and B domains); the interaction promotes sumoylation of DNM1L, mainly in its B domain (By similarity). Interacts with NFATC2IP; this inhibits formation of poly-SUMO chains (By similarity). Interacts with FHIT (By similarity). Interacts with PRKRA and p53/TP53 (By similarity). Interacts with UHRF2 (By similarity). Interacts with NR3C1 and this interaction is enhanced in the presence of RWDD3 (By similarity). Interacts with MTA1 (By similarity). Interacts with ZNF451 (By similarity). Interacts with CPEB3 (By similarity). Interacts with SUMO1, SUMO2, and SUMO3 (By similarity). Interacts with IPO13 (By similarity). Interacts with DNMT1 (By similarity).
messages: Nucleus
messages: Phosphorylation at Ser-71 significantly enhances SUMOylation activity.

10116:Pgm5
gene id: 10116:Pgm5
uniprot id: A0A8I6AHF8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

10116:Camta2
gene id: 10116:Camta2
uniprot id: D3ZLG1
names: Similarity
names: Subunit
messages: Belongs to the CAMTA family.
messages: May interact with calmodulin.

10116:Camkv
gene id: 10116:Camkv
uniprot id: Q63092
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Expressed from day 16 dpc, but accumulation was primarily postnatal with maximal steady state levels reached at postnatal day 10.
messages: Expressed in brain and weakly in eye. Not detected in liver, kidney, spleen, thymus, bladder, aorta, lung, intestine, esophagus, stomach, skeletal muscle, heart, diaphragm, uterus, tail skin, submaxillary gland, prostate, ear, epididymis, placenta, pancreas, ovary, testis, adrenal gland, parathyroid gland, thyroid gland, pineal gland, pituitary and sciatic nerve. In adult hippocampus, predominantly expressed in caudate nucleus, cortex, hypothalamus, olfactory bulb, and midbrain and faintly in pons, brainstem and spinal cord.
messages: Has no detectable kinase activity in vitro.
messages: Interacts with calmodulin, in the presence of calcium.
messages: The protein kinase domain is predicted to be catalytically inactive.

10116:RGD1306474
gene id: 10116:RGD1306474
uniprot id: A6IGS1
uniprot id: D4A0W2
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

10116:Qrsl1
gene id: 10116:Qrsl1
uniprot id: Q5FWT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

10116:Olfml2a
gene id: 10116:Olfml2a
uniprot id: A6JEV4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Ltb4r2
gene id: 10116:Ltb4r2
uniprot id: Q924U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).

10116:Actb
gene id: 10116:Actb
uniprot id: A6K1N6
uniprot id: P60711
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).
messages: Belongs to the actin family.
messages: Expressed in the epididymis (at protein level).
messages: ISGylated.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-73 by SETD3 (PubMed:30526847). Methylation at His-73 is required for smooth muscle contraction of the laboring uterus during delivery (By similarity).
messages: Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
messages: N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins. In contrast, filament nucleation by the Arp2/3 complex is not affected.
messages: N-terminal cleavage of acetylated methionine of immature cytoplasmic actin by ACTMAP.
messages: Nucleus
messages: Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with XPO6 and EMD. Interacts with ERBB2. Interacts with GCSAM (By similarity). Interacts with TBC1D21. Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (By similarity). Interacts with DHX9 (via C-terminus); this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes. Interacts with FAM107A (By similarity). Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The filament contains 8 copies of ACTR1A and 1 ACTB (By similarity).
messages: cytoskeleton

10116:Pth1r
gene id: 10116:Pth1r
uniprot id: A6I3G5
uniprot id: P25961
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Interacts (via N-terminal extracellular domain) with PTHLH and PTH (PubMed:1313566). Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer (By similarity).
messages: Membrane
messages: N-glycosylated.
messages: Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

10116:Nrg2
gene id: 10116:Nrg2
uniprot id: O35569
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
messages: ERBB receptor binding is elicited entirely by the EGF-like domain.
messages: Expressed in most parts of the brain, especially the olfactory bulb and cerebellum where it localizes in granule and Purkinje cells. In the hippocampus, found in the granule cells of the dentate gyrus. In the basal forebrain, found in the cholinergic cells. In the hindbrain, weakly detectable in the motor trigeminal nucleus. Not detected in the hypothalamus. Also found in the liver and in the thymus. Not detected in heart, adrenal gland, or testis.
messages: Expressed in the brain of 11.5 dpc embryos where it is found in the telencephalon, but not in the hindbrain. Not found in the heart. In the adult, found in brain and thymus.
messages: Extensive glycosylation precedes the proteolytic cleavage.
messages: Interacts with ERBB3 and ERBB4.
messages: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
messages: Secreted
messages: The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).

10116:Rpap2
gene id: 10116:Rpap2
uniprot id: A0A8L2PZW5
uniprot id: A6KPI3
uniprot id: A6KPI4
uniprot id: Q5I0E6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD (By similarity).
messages: Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.
messages: Belongs to the RPAP2 family.
messages: Cytoplasm
messages: Nucleus
messages: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (By similarity).
messages: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.

10116:Entpd7
gene id: 10116:Entpd7
uniprot id: A6JHD4
uniprot id: D3ZNB5
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

10116:Clcn6
gene id: 10116:Clcn6
uniprot id: A6IU39
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Harbi1
gene id: 10116:Harbi1
uniprot id: B0BN95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Interacts with NAIF1.
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity (By similarity).

10116:Dguok
gene id: 10116:Dguok
uniprot id: A6IAM4
uniprot id: A6IAM5
uniprot id: D3ZDE4
names: Similarity
messages: Belongs to the DCK/DGK family.

10116:Mtmr2
gene id: 10116:Mtmr2
uniprot id: A0A8I5ZTB8
uniprot id: A6JN73
uniprot id: A6JN75
uniprot id: D3ZA31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

10116:Foxm1
gene id: 10116:Foxm1
uniprot id: A0A8I6A7T5
uniprot id: A6IM06
uniprot id: D3ZLE1
names: Subcellular Location Annotation
messages: Nucleus

10116:Sumo3
gene id: 10116:Sumo3
uniprot id: A6JK81
uniprot id: Q5XIF4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.
messages: Cytoplasm
messages: Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity. Interacts with BMAL1 (By similarity).
messages: Nucleus
messages: PML body
messages: Polymeric chains can be formed through Lys-11 cross-linking.
messages: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX (By similarity).

10116:Prdm10
gene id: 10116:Prdm10
uniprot id: D3ZQ79
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

10116:Psme4
gene id: 10116:Psme4
uniprot id: A0A0G2K9R9
uniprot id: A6JQD1
names: Similarity
messages: Belongs to the BLM10 family.

10116:S100a8
gene id: 10116:S100a8
uniprot id: A6J6Q3
uniprot id: P50115
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the S-100 family.
messages: Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer. Preferentially exists as a heterodimer or heterotetramer with S100A9 known as calprotectin (S100A8/A9). S100A8 interacts with AGER, ATP2A2 and with the heterodimeric complex formed by TLR4 and LY96. Calprotectin (S100A8/9) interacts with CEACAM3 and tubulin filaments in a calcium-dependent manner. Heterotetrameric calprotectin (S100A8/A9) interacts with ANXA6 and associates with tubulin filaments in activated monocytes. S100A8 and calprotectin (S100A8/9) interact with NCF2/P67PHOX, RAC1 and RAC2. Calprotectin (S100A8/9) interacts with CYBA and CYBB (By similarity). Calprotectin (S100A8/9) interacts with NOS2 to form the iNOS-S100A8/A9 transnitrosylase complex (By similarity).
messages: S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve pro-inflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its pro-inflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the pro-inflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role a…
messages: Secreted
messages: cytoskeleton

10116:Or1e16
gene id: 10116:Or1e16
uniprot id: A0A8I5ZZE7
uniprot id: A6HGK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Itfg1
gene id: 10116:Itfg1
uniprot id: A6KDC8
uniprot id: F7FNV8
names: Similarity
messages: Belongs to the TIP family.

10116:Cep290
gene id: 10116:Cep290
uniprot id: A0A0G2K715
uniprot id: A0A0G2K929
names: Subcellular Location Annotation
messages: cilium basal body

10116:Trpv4
gene id: 10116:Trpv4
uniprot id: A6J1Z3
uniprot id: Q9ERZ8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily.
messages: Cell membrane
messages: Expressed lung, spleen, kidney, testis, fat, and at very low levels in trigeminal ganglia.
messages: Homotetramer. Interacts with calmodulin (By similarity). Interacts with MAP7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES (By similarity). Interacts with CTNNB1 (By similarity). The TRPV4 and CTNNB1 complex can interact with CDH1 (By similarity). Part of a complex containing MLC1, AQP4, HEPACAM and ATP1B1 (By similarity). Interacts with PACSIN1, PACSIN2 and PACSIN3 (via SH3 domain) (PubMed:16627472). Interacts with ITPR3 (By similarity). Interacts with AQP5; the interaction is probably indirect and regulates TRPV4 activation by hypotonicity (By similarity). Interacts with ANO1 (By similarity). Interacts (via C-terminus) with PKD2 (via C-terminus) (By similarity). Interacts with DDX3X; this interaction is decreased when the channel is activated (By similarity).
messages: Membrane
messages: N-glycosylated.
messages: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:11081638). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:11081638). Also activated by heat, low pH, citrate and phorbol esters (By similarity). Increase of intracellular Ca(2+) potentiates currents (By similarity). Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (By similarity). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (By similarity). Together with PKD2, forms mechano- and thermosensitive channels in cilium (By similarity). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to pro-inflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (By similarity). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (By similarity).
messages: The ANK repeat region mediates interaction with Ca(2+)-calmodulin and ATP binding. The ANK repeat region mediates interaction with phosphatidylinositol-4,5-bisphosphate and related phosphatidylinositides.
messages: adherens junction
messages: cilium

10116:Or52ab4
gene id: 10116:Or52ab4
uniprot id: M0RDW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ftmt
gene id: 10116:Ftmt
uniprot id: A6IX12
uniprot id: D3ZUG8
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

10116:Iscu
gene id: 10116:Iscu
uniprot id: B2RZ79
uniprot id: F6T7V8
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex.

10116:Lgals1
gene id: 10116:Lgals1
uniprot id: P11762
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD6, CD7, CD43, ALCAM and CD45. Interacts with laminin (via poly-N-acetyllactosamine). Interacts with SUSD2. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.
messages: Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
messages: Secreted
messages: extracellular matrix

10116:Spcs2
gene id: 10116:Spcs2
uniprot id: D3ZD11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:Hap1
gene id: 10116:Hap1
uniprot id: P54256
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Early endosome
messages: Endoplasmic reticulum
messages: In the brain, especially in the olfactory bulb and in the brain stem. No detectable expression in peripheral tissues such as lung, testis, spleen, and small intestine.
messages: Isoform A is phosphorylated on Thr-598.
messages: Lysosome
messages: Mitochondrion
messages: Nucleus
messages: Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to facilitate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca(2+) release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in regulation of exocytosis.…
messages: Presynapse
messages: Self-associates. Interacts with HTT/huntingtin; enhanced by an expanded polyglutamine repeat within HTT. Isoform A interacts with DCTN1; decreased in presence of HTT with expanded polyglutamine repeat; decreased by phosphorylation of Hap1 isoform A at Thr-598. Isoform A interacts with KLC2; decreased by phosphorylation of Hap1 isoform A at Thr-598. Isoform A interacts with ITPR1 and APP. Isoform A interacts with AR; decreased by an expanded polyglutamine repeat within AR. Isoform A interacts with YWHAZ; enhanced by phosphorylation of Hap1 isoform A at Thr-598. Isoform A interacts with BDNF and SORT1; probably forming a complex involved in proBDNF trafficking, degradation and processing. Interacts with TBP, AHI1, HGS and KALRN. Interacts with KIF5A, KIF5B, KIF5C and GABRB3; indicative for an HAP1:KIF5 complex transporting a GABA(A) receptor as cargo. Interacts with ATXN3; in STBs. Interacts with NTRK2; HAP1 stabilizes association of NTRK2 with SORT1 preventing NTRK2 degradation. Interacts with CCDC113.
messages: autophagosome
messages: axon
messages: cytoskeleton
messages: dendrite
messages: dendritic spine
messages: growth cone
messages: neuron projection
messages: synaptic vesicle

10116:Tspan17
gene id: 10116:Tspan17
uniprot id: A0A0G2JZH6
uniprot id: A6KAW6
uniprot id: A6KAW7
uniprot id: Q4V8E0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Interacts with ADAM10.
messages: Membrane
messages: Regulates ADAM10 maturation.

10116:Tmem138
gene id: 10116:Tmem138
uniprot id: B1WBM3
uniprot id: Q6P7P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

10116:Cdh18
gene id: 10116:Cdh18
uniprot id: F1M702
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

10116:Dmrtc1a
gene id: 10116:Dmrtc1a
uniprot id: Q4QR87
names: Caution
names: Similarity
messages: Although related to other DMRT proteins, it does not contain a canonical DM DNA-binding domain.
messages: Belongs to the DMRT family.

10116:Rab35
gene id: 10116:Rab35
uniprot id: Q5U316
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Endosome
messages: Interacts with DENND1A and DENND1B; in a nucleotide-dependent manner. Interacts with DENND1C; weak interaction which is nucleotide-independent (By similarity). Interacts (GTP-bound form) with ACAP2 and MICALL1; the interaction is direct and probably recruits ACAP2 and MICALL1 to membranes (PubMed:23572513). Interacts with EHD1; the interaction is indirect through MICALL1 and probably recruits EHD1 to membranes (By similarity). Interacts with GDI1, GDI2 and CHM; phosphorylation at Thr-72 disrupts these interactions (By similarity).
messages: Melanosome
messages: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). That Rab is activated by the guanine exchange factors DENND1A, DENND1B and DENND1C (By similarity).
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes (By similarity).
messages: clathrin-coated pit
messages: clathrin-coated vesicle

10116:Or12k8
gene id: 10116:Or12k8
uniprot id: A0A8I5ZSE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ndst2
gene id: 10116:Ndst2
uniprot id: A6KKQ5
uniprot id: D3ZD62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

10116:Skic2
gene id: 10116:Skic2
uniprot id: Q6MG76
names: Subcellular Location Annotation
messages: Cytoplasm

10116:Sgcz
gene id: 10116:Sgcz
uniprot id: A0A0G2K1J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

10116:Chst14
gene id: 10116:Chst14
uniprot id: B2GV63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

10116:Or52b4
gene id: 10116:Or52b4
uniprot id: A6I745
uniprot id: D4A4P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Eaf1
gene id: 10116:Eaf1
uniprot id: A6KFY7
uniprot id: D4A2G7
names: Similarity
messages: Belongs to the EAF family.

10116:Aph1b
gene id: 10116:Aph1b
uniprot id: Q0PY50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

10116:Ddx55
gene id: 10116:Ddx55
uniprot id: A6J0Y4
uniprot id: D3ZX56
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

10116:Casq1
gene id: 10116:Casq1
uniprot id: A6JG37
uniprot id: P19633
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:8042990). Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction (By similarity). Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity).
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Detected in skeletal muscle and in smooth muscle from vas deferens, aorta and stomach (at protein level).
messages: Endoplasmic reticulum
messages: Mitochondrion matrix
messages: Monomer; increases in response to a depletion of intracellular calcium. Homodimer. Homotetramer and homopolymer. Can form linear homooligomers. Ca(2+) ions promote oligomerization. Interacts (via C-terminal end and preferentially with the monomeric form) with STIM1; this interaction increases in response to a depletion of intracellular calcium, decreases both STIM1 aggregation and clustering, interaction of STIM1 with ORAI1 and store-operated Ca(2+) entry (SOCE) activity. Interacts with ASPH and TRDN.
messages: N-glycosylated.
messages: Sarcoplasmic reticulum
messages: Sarcoplasmic reticulum lumen
messages: Sarcoplasmic reticulum membrane

10116:Prokr2
gene id: 10116:Prokr2
uniprot id: Q8R415
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundantly expressed in the CNS and reproductive organs with the highest levels in the cerebrum, cerebellum, testis and ovary.
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homodimer.
messages: Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase (By similarity).

10116:Slc14a2
gene id: 10116:Slc14a2
uniprot id: A6KMY1
uniprot id: A6KMY2
uniprot id: A6KMY3
uniprot id: Q62668
names: Activity Regulation
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Expressed in both the inner and outer renal medulla of the kidney.
messages: Expressed in the inner medulla of the kidney.
messages: Induced by dehydration.
messages: Inhibited by phloretin (PubMed:8958221). Activated by vasopressin, forskolin, 3-isobutyl-1-methylxanthine (IBMX) and cAMP (PubMed:16959825).
messages: Inhibited by phloretin and activated by forskolin.
messages: Inhibited by phloretin.
messages: Inhibited by urea analogs and phloretin and activated by forskolin.
messages: Interacts with SNAPIN which enhances its urea transport activity.
messages: It is uncertain whether Met-1 or Met-9 is the initiator.
messages: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism.
messages: Membrane

10116:Mrpl35
gene id: 10116:Mrpl35
uniprot id: A6IA89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

10116:Cenps
gene id: 10116:Cenps
uniprot id: A6IUA1
names: Similarity
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.

10116:Gpr61
gene id: 10116:Gpr61
uniprot id: A6HUY3
uniprot id: D4A0Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

10116:Npb
gene id: 10116:Npb
uniprot id: A6HLG2
uniprot id: Q8K4P2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the neuropeptide B/W family.
messages: Detected in a variety of tissues. High levels are found in the lymphoid organs, central nervous system, mammary gland and uterus.
messages: May be involved in the regulation of feeding, neuroendocrine system, memory and learning. May be involved in the afferent pain pathway (By similarity).
messages: Secreted

10116:Clpsl2
gene id: 10116:Clpsl2
uniprot id: D3ZVN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the colipase family.
messages: Secreted

10116:Fra10ac1
gene id: 10116:Fra10ac1
uniprot id: Q5FVF1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with ESS2.
messages: May be involved in pre-mRNA splicing.
messages: Nucleus

10116:Mrps7
gene id: 10116:Mrps7
uniprot id: A6HKP1
uniprot id: Q5I0K8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

10116:Dyrk3
gene id: 10116:Dyrk3
uniprot id: A6IC13
uniprot id: Q4V8A3
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material. Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues. Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1. Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3. Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis. Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling. When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling. Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis.
messages: Expressed predominantly in testis (PubMed:9748265). Expressed in late pachytene spermatocytes (PubMed:17292540).
messages: Interacts with SIRT1.
messages: Nucleus
messages: Nucleus speckle
messages: Protein kinase activity is activated following autophosphorylation at Tyr-368.
messages: The N-terminal domain, which is intrinsically disordered, is required for stress granule localization.
messages: Ubiquitinated at anaphase by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome.
messages: centrosome

10116:Abcc3
gene id: 10116:Abcc3
uniprot id: O88563
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (By similarity). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity).
messages: Basal cell membrane
messages: Basolateral cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Expressed in lung, ileum, colon and liver. Higher in liver of Eisai hyperbilirubinemic rats.
messages: Strongly up-regulated under conditions of cholestasis.

10116:Gprc5d
gene id: 10116:Gprc5d
uniprot id: A6IMF4
uniprot id: D4A7N4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Bod1
gene id: 10116:Bod1
uniprot id: A0A0H2UHS5
uniprot id: A6HDC9
uniprot id: Q6AYJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BOD1 family.
messages: Component of the SET1B complex composed of the catalytic subunit SETD1B, WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1, DPY30 homotrimer and BOD1.
messages: Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.
messages: centrosome
messages: kinetochore

10116:St13
gene id: 10116:St13
uniprot id: A6HSZ6
uniprot id: P50503
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAM10 family.
messages: Cytoplasm
messages: Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90. Interacts (via the C-terminus 302- 318 AA) with GRK5 (By similarity).
messages: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.

10116:Lrrc66
gene id: 10116:Lrrc66
uniprot id: Q6TXF5
names: Subcellular Location Annotation
messages: Membrane

10116:Pinx1
gene id: 10116:Pinx1
uniprot id: A4L691
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PINX1 family.
messages: Interacts with MCRS1, TERT, TERF1, NCL/nucleolin, and the telomerase RNA.
messages: Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor (By similarity).
messages: Nucleus
messages: The TBM domain mediates interaction with TERF1.
messages: The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibits its activity.
messages: kinetochore
messages: nucleolus
messages: telomere

10116:Gapdh
gene id: 10116:Gapdh
uniprot id: A6ILS6
uniprot id: P04797
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Glyceraldehyde-3-phosphate dehydrogenase activity is inhibited by fumarate, via the formation of S-(2-succinyl)cysteine residues.
messages: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:17934141, PubMed:15951807, PubMed:20972425). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:17934141). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (PubMed:15312048). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (By similarity). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (PubMed:10424669, PubMed:15951807, PubMed:20972425). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (PubMed:15951807, PubMed:20972425).
messages: High levels in skeletal muscle and heart, low levels in liver, brain, and kidney.
messages: Homotetramer (By similarity). Interacts with TPPP; the interaction is direct (By similarity). Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation (PubMed:15951807, PubMed:19607794). Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation (PubMed:19607794). Interacts with CHP1; the interaction increases the binding of CHP1 with microtubules (PubMed:15312048). Associates with microtubules (PubMed:15312048). Interacts with EIF1AD, USP25, PRKCI and WARS1. Interacts with phosphorylated RPL13A; inhibited by oxidatively-modified low-densitity lipoprotein (LDL(ox)). Component of the GAIT complex. Interacts with FKBP6; leading to inhibit GAPDH catalytic activity. Interacts with TRAF2, promoting TRAF2 ubiquitination. Interacts with TRAF3, promoting TRAF3 ubiquitination (By similarity).
messages: Homotetramer.
messages: ISGylated.
messages: Nucleus
messages: Oxidative stress can promote the formation of high molecular weight disulfide-linked GAPDH aggregates, through a process called nucleocytoplasmic coagulation.
messages: S-nitrosylation of Cys-150 leads to interaction with SIAH1, followed by translocation to the nucleus (PubMed:1281150, PubMed:15951807, PubMed:20972425, PubMed:8626764). The effect of S-nitrosylation on enzymatic activity is unclear: according to some authors, it inhibits enzymatic activity and increases endogenous ADP-ribosylation, inhibiting the enzyme in a non-reversible manner (PubMed:8626764). According to others, it does not affect glycolysis (PubMed:15951807). ADP-ribosylation is likely to be a pathophysiological event associated with inhibition of gluconeogenesis (PubMed:8626764). S-nitrosylation of Cys-245 is induced by interferon-gamma and LDL(ox) implicating the iNOS-S100A8/9 transnitrosylase complex and seems to prevent interaction with phosphorylated RPL13A and to interfere with GAIT complex activity (By similarity).
messages: Succination of Cys-150 and Cys-245 by the Krebs cycle intermediate fumarate, which leads to S-(2-succinyl)cysteine residues, inhibits glyceraldehyde-3-phosphate dehydrogenase activity. Fumarate concentration as well as succination of cysteine residues in GAPDH is significantly increased in muscle of diabetic rats. It was proposed that the S-(2-succinyl)cysteine chemical modification may be a useful biomarker of mitochondrial and oxidative stress in diabetes and that succination of GAPDH and other thiol proteins by fumarate may contribute to the metabolic changes underlying the development of diabetes complications.
messages: Sulfhydration at Cys-150 increases catalytic activity.
messages: The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
messages: cytoskeleton
messages: cytosol

10116:Tm4sf4
gene id: 10116:Tm4sf4
uniprot id: A6JVG1
uniprot id: Q9EQL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the L6 tetraspanin family.
messages: Expressed in liver and testis. Up-regulated in regenerating liver after partial hepatectomy.
messages: Membrane
messages: Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation (By similarity).

10116:Dlgap5
gene id: 10116:Dlgap5
uniprot id: B1WC75
names: Similarity
messages: Belongs to the SAPAP family.

10116:Setd2
gene id: 10116:Setd2
uniprot id: A6I3F0
uniprot id: D4A5H6
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

10116:Efna1
gene id: 10116:Efna1
uniprot id: A6J6E5
uniprot id: P97553
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer. Homodimer. Forms heterodimers with EPHA2. Binds to the receptor tyrosine kinases EPHA2, EPHA3, EPHA4, EPHA5, EPHA6 and EPHA7. Also binds with low affinity to EPHA1 (By similarity).
messages: N-Glycosylation is required for binding to EPHA2 receptor and inducing its internalization.
messages: Secreted
messages: Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form.

10116:Fev
gene id: 10116:Fev
uniprot id: A6JVW5
uniprot id: O70132
names: Developmental Stage
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ETS family.
messages: Contaminating sequence. Sequence of unknown origin in the N-terminal part.
messages: Earliest expression is detected at 12.5 dpc in the developing brain in regions corresponding to the future rostral and caudal serotonergic neuron clusters.
messages: Functions as a transcriptional regulator. May function as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.
messages: Nucleus
messages: Specifically expressed in central serotonergic neurons. Also expressed in adrenal gland and to a lower extent in small intestine and eye.

10116:Acox1
gene id: 10116:Acox1
uniprot id: A6HKU7
uniprot id: P07872
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the acyl-CoA oxidase family.
messages: Expressed in Schwann cells (PubMed:32169171). Expressed (at protein level) in liver (PubMed:1400324).
messages: Homodimer. The enzyme contains three components A, B and C, the latter two being produced from the first by a proteolytic cleavage. Interacts with LONP2 (By similarity).
messages: Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids. Catalyzes the desaturation of fatty acyl-CoAs such as palmitoyl-CoA (hexadecanoyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs) such as (2E)-hexadecenoyl-CoA, and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)).
messages: Is active against a much broader range of substrates and shows activity towards long-chain acyl-CoAs.
messages: Peroxisome
messages: Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro.

10116:Cdh15
gene id: 10116:Cdh15
uniprot id: Q75NI5
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

10116:Casp12
gene id: 10116:Casp12
uniprot id: Q920D5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by two subunits (Potential). May interact with TRAF2 (By similarity).
messages: Involved in the activation cascade of caspases responsible for apoptosis execution.

10116:Prss45
gene id: 10116:Prss45
uniprot id: Q6IE62
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: In contrast to other members of the family, lacks the conserved Ser at position 243 which is replaced by a Pro residue, suggesting it is inactive.
messages: Secreted

10116:Or2c1
gene id: 10116:Or2c1
uniprot id: A6K4V0
uniprot id: G3V9S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Canx
gene id: 10116:Canx
uniprot id: A6HE13
uniprot id: P35565
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calreticulin family.
messages: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Interacts with MAPK3/ERK1 (PubMed:10393181). Interacts with KCNH2 (By similarity). Associates with ribosomes (PubMed:10393181). Interacts with SGIP1; involved in negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins (By similarity). Interacts with SERPINA2P/SERPINA2 and with the S and Z variants of SERPINA1 (By similarity). Interacts with PPIB (By similarity). Interacts with ZNRF4 (By similarity). Interacts with SMIM22 (By similarity). Interacts with TMX2 (By similarity). Interacts with TMEM35A/NACHO and CHRNA7 (By similarity). Interacts with reticulophagy regulators RETREG2 and RETREG3 (By similarity). Interacts with DNM1L; may form part of a larger protein complex at the ER-mitochondrial interface during mitochondrial fission (By similarity). Interacts with ADAM7 (By similarity).
messages: Melanosome
messages: Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins (By similarity).
messages: Phosphorylated at Ser-563 by MAPK3/ERK1. Phosphorylation by MAPK3/ERK1 increases its association with ribosomes.
messages: Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4.

10116:Ccser1
gene id: 10116:Ccser1
uniprot id: A6KF12
uniprot id: D3ZTW6
names: Similarity
messages: Belongs to the CCSER family.

10116:Or6k2
gene id: 10116:Or6k2
uniprot id: A0A0G2K0S9
uniprot id: A6JGA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Cilp
gene id: 10116:Cilp
uniprot id: A6J5E6
uniprot id: D3ZGB8
names: Subcellular Location Annotation
messages: extracellular matrix

10116:Pomc
gene id: 10116:Pomc
uniprot id: F6PTD9
uniprot id: Q8K422
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
messages: Belongs to the POMC family.
messages: Endogenous opiate.
messages: Endogenous orexigenic opiate.
messages: Secreted
messages: Stimulates the adrenal glands to release cortisol.

10116:Ace3
gene id: 10116:Ace3
uniprot id: M0RB66
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.

10116:Zar1
gene id: 10116:Zar1
uniprot id: Q7TSX9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZAR1 family.
messages: Cytoplasm
messages: Cytoplasmic ribonucleoprotein granule
messages: Disordered region at the N-terminus undergoes liquid-liquid phase separation (LLPS) for the formation of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes.
messages: Interacts with YBX2.
messages: Phosphorylation by CDK1 does not regulate formation of MARDO (mitochondria-associated ribonucleoprotein domain) membraneless compartment.
messages: The 3CxxC-type mediates binding to the 3'-UTR of mRNAs.
messages: Ubiquitinated and degradaded by the proteasome during oocyte meiotic maturation, leading to MARDO (mitochondria-associated ribonucleoprotein domain) membraneless compartment dissolution.
messages: mRNA-binding protein that mediates formation of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. MARDO assembly around mitochondria is directed by an increase in mitochondrial membrane potential during oocyte growth. Promotes formation of MARDO phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to maternal mRNAs. Binds to the 3'-UTR of maternal mRNAs. Maternal mRNAs stored in the MARDO are translationally repressed. Essential for female fertility and oocyte-to-embryo transition by coordinating maternal mRNA storage, translation and degradation.

10116:Olr1093
gene id: 10116:Olr1093
uniprot id: D3ZTF8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Or4a70
gene id: 10116:Or4a70
uniprot id: A6HN42
uniprot id: D3ZC17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Afp
gene id: 10116:Afp
uniprot id: A6KKF8
uniprot id: G3V6D0
names: Subcellular Location Annotation
messages: Secreted

10116:Trappc3
gene id: 10116:Trappc3
uniprot id: A6ISA1
uniprot id: Q5U1Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: Homodimer. Component of the multisubunit transport protein particle (TRAPP) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Heterodimer with TRAPPC6A. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L. Heterodimer with TRAPPC6b. The heterodimer TRAPPC6B-TRAPPC3 interacts with TRAPPC1 likely providing a core for TRAPP complex formation.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

10116:Cpsf2
gene id: 10116:Cpsf2
uniprot id: A6JEJ7
uniprot id: D3Z9E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

10116:Pdcd2
gene id: 10116:Pdcd2
uniprot id: P47816
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: By irradiation and dexamethasone.
messages: Expressed during apoptosis.
messages: May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.
messages: Nucleus
messages: Ubiquitinated by PRKN, promoting proteasomal degradation.

10116:Nat8b
gene id: 10116:Nat8b
uniprot id: Q9JIY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the camello family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with PROM1. Interacts with BACE1.
messages: May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins (By similarity). Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (By similarity). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (By similarity). May play a role in regulation of gastrulation (PubMed:11397015).

10116:Krt39
gene id: 10116:Krt39
uniprot id: Q6IFW3
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Heterotetramer of two type I and two type II keratins.
messages: May play a role in late hair differentiation.
messages: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

10116:Tmem107
gene id: 10116:Tmem107
uniprot id: A6HFN0
uniprot id: A6HFN3
uniprot id: D3ZFW5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Part of the tectonic-like complex (also named B9 complex). Interacts with TMEM237, TMEM231, MKS1 and TMEM216.
messages: Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity). During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins (By similarity).
messages: cilium

10116:Lipi
gene id: 10116:Lipi
uniprot id: A6JL12
uniprot id: D3ZMG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

10116:Plac8
gene id: 10116:Plac8
uniprot id: B5DF36
names: Similarity
messages: Belongs to the cornifelin family.

10116:Slc16a14
gene id: 10116:Slc16a14
uniprot id: A6JWD3
uniprot id: A6JWD4
uniprot id: D4A0E5
names: Subcellular Location Annotation
messages: Membrane

10116:Or5h24
gene id: 10116:Or5h24
uniprot id: A0A8I6API7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Cab39l
gene id: 10116:Cab39l
uniprot id: F7FIZ4
uniprot id: Q5XIJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

10116:Exosc2
gene id: 10116:Exosc2
uniprot id: A6JU28
uniprot id: D3ZBP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

10116:Noc3l
gene id: 10116:Noc3l
uniprot id: A6I192
uniprot id: D4AB23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: nucleolus

10116:Tmco4
gene id: 10116:Tmco4
uniprot id: F1LRM3
uniprot id: Q499U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO4 family.
messages: Membrane

10116:Slc66a2
gene id: 10116:Slc66a2
uniprot id: A6K5H2
uniprot id: Q5M880
names: Subcellular Location Annotation
messages: Membrane

10116:Ppa2
gene id: 10116:Ppa2
uniprot id: D4A830
names: Similarity
messages: Belongs to the PPase family.

10116:Nox1
gene id: 10116:Nox1
uniprot id: Q9WV87
names: Activity Regulation
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in vascular smooth muscle cells.
messages: NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interacts with NOXA1 and NOXO1 (By similarity).
messages: Pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism.
messages: The oxidase activity is potentiated by NOXA1 and NOXO1.
messages: invadopodium membrane

10116:Exoc2
gene id: 10116:Exoc2
uniprot id: A0A0G2K416
uniprot id: O54921
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.
messages: Interacts with RALA through the TIG domain.
messages: Midbody ring
messages: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (PubMed:9405631, PubMed:26582389). Interacts with EXOC3L1 (By similarity). Interacts with GNEFR/DELGEF; this interaction occurs only in the presence of magnesium or manganese and is stimulated by dCTP or GTP (By similarity). Interacts with RALA and RALB (PubMed:11744922, PubMed:12839989). Interacts with ARL13B; regulates ARL13B localization to the cilium membrane.

10116:Tfip11
gene id: 10116:Tfip11
uniprot id: A6J264
uniprot id: Q5U2Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2 (By similarity).
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix (By similarity).
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

10116:Epb42
gene id: 10116:Epb42
uniprot id: A6HPL9
uniprot id: F7F1R4
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.

10116:Dck
gene id: 10116:Dck
uniprot id: P48769
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DCK/DGK family.
messages: Homodimer.
messages: Nucleus
messages: Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.
messages: Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine.

10116:Ptma
gene id: 10116:Ptma
uniprot id: A6JWI4
uniprot id: P06302
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pro/parathymosin family.
messages: Covalently linked to a small RNA of about 20 nucleotides.
messages: Interacts with NUPR1; regulates apoptotic process.
messages: Nucleus
messages: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.

10116:Prdm12
gene id: 10116:Prdm12
uniprot id: D3ZEJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Involved in the positive regulation of histone H3-K9 dimethylation.
messages: Nucleus

10116:Itpripl2
gene id: 10116:Itpripl2
uniprot id: B2RYE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

10116:Cox15
gene id: 10116:Cox15
uniprot id: A6JHD6
uniprot id: D4A414
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

10116:Maf
gene id: 10116:Maf
uniprot id: P54844
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T-helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf-responsive element binding (By similarity).
messages: Belongs to the bZIP family. Maf subfamily.
messages: Expressed in lens cells at 12 dpc. Expressed in the cartilage of ribs and limbs, in the eyes and spinal cord at 15 dpc. Expressed in the outer equatorial epithelium and lens fibers at 16 dpc (at protein level). Expressed throughout the lens fiber cells at 13 and 16 dpc; not detected in the epithelium of the lens. In the eyes, confined to the lens; not detected in the retina at 15 dpc. In spinal cord, expressed in the dorsal and ventral part of the dorsal horn at 15 dpc. Predominantly expressed in post-mitotic cells.
messages: Expressed in the muscle, uterus, intestine, kidney, liver and skin. Expressed in the lens epithelial and fiber cells.
messages: Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a homodimer or as a heterodimer. Heterotetramer of two MAF and two USF2. Interacts with PAX6; the interaction is direct. Interacts with MYB; interaction takes place weakly in normal T-cells and increases in T-cells following stimulation through the TCR engagement. Interacts with MYB; the ternary complex formed with MYB and the CD13 promoter is regulated in response to differentiating signals. Interacts with USF2; the interaction inhibits its DNA-binding activity on the L7 promoter. Interacts with CREBBP, EP300 and ETS1 (By similarity).
messages: Nucleus
messages: Phosphorylated by GSK3 and MAPK13 on serine and threonine residues. The phosphorylation status can serve to either stimulate or inhibit transcription (By similarity).
messages: Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is triggered by glucocorticoids (By similarity).

10116:Sftpb
gene id: 10116:Sftpb
uniprot id: P22355
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer; disulfide-linked.
messages: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).
messages: Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
messages: surface film

10116:Ctsf
gene id: 10116:Ctsf
uniprot id: A9LRS7
uniprot id: Q499S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

10116:Crybg2
gene id: 10116:Crybg2
uniprot id: A0A0G2JVZ7
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

10116:Rpl4
gene id: 10116:Rpl4
uniprot id: P50878
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Citrullinated by PADI4.
messages: Component of the large ribosomal subunit. May bind IPO9 with low affinity (By similarity). Interacts with RBM3 (PubMed:15684048).
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

10116:Klrb1
gene id: 10116:Klrb1
uniprot id: Q0ZUP0
names: Subcellular Location Annotation
messages: Membrane

10116:Dnph1
gene id: 10116:Dnph1
uniprot id: A6JIQ6
uniprot id: O35820
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
messages: Cytoplasm
messages: Highly expressed in heart, kidney, liver and spleen. Weakly expressed in lung and skeletal muscle.
messages: Inhibited by zinc ions. Competitive inhibition of dGMP hydrolysis by GMP and 6-methylthio-GMP.
messages: Monomer and homodimer.
messages: Nucleus
messages: Up-regulated in response to c-Myc and by partial hepatectomy.

10116:Rhox13
gene id: 10116:Rhox13
uniprot id: F1M524
names: Subcellular Location Annotation
messages: Nucleus

10116:Foxo4
gene id: 10116:Foxo4
uniprot id: A6IQA5
uniprot id: D4A433
names: Subcellular Location Annotation
messages: Nucleus

10116:Gmnn
gene id: 10116:Gmnn
uniprot id: A6KLF9
uniprot id: D3ZWJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

10116:Hdac1l
gene id: 10116:Hdac1l
uniprot id: D3ZVU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.
messages: Nucleus

10116:Septin8
gene id: 10116:Septin8
uniprot id: A6HED2
uniprot id: G3V9Z6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

10116:Trim28
gene id: 10116:Trim28
uniprot id: O08629
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylated by SIRT6, promoting TRIM28/KAP1 interaction with CBX5, thereby contributing to the packaging of LINE-1 retrotransposon elements into transcriptionally repressive heterochromatin.
messages: ATM-induced phosphorylation on Ser-825 represses sumoylation leading to the de-repression of expression of a subset of genes involved in cell cycle control and apoptosis in response to genotoxic stress. Dephosphorylation by the phosphatases, PPP1CA and PP1CB forms, allows sumoylation and expression of TRIM28 target genes.
messages: Auto-ubiquitinated; enhanced by MAGEA2 and MAGEC2.
messages: Belongs to the TRIM/RBCC family.
messages: Citrullinated by PADI4.
messages: Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
messages: Interacts with ZNF382 (PubMed:11154279). Interacts with SETX. Oligomer; the RBCC domain homotrimerizes and interacts with one molecule of KRAB to form the KRAB-KAP1 corepressor complex. Binding to a KRAB domain is an absolute requirement for silencing gene expression. Interacts with CEBPB and NR3C1. Interacts with a number of KRAB-ZFP proteins including ZNF10, ZFP53, ZFP68 and ZNF256. Interacts with NCOR1, NR3C1 and CHD3. Interacts with CEBPB (via the RING-type and PHD-type zinc fingers). Component of a ternary complex that includes TRIM28, a HP1 protein (CBX1, CBX3 OR CBX5), a KRAB domain-containing protein, and DNA. Interacts with CBX5 (via the PxVxL motif); the interaction occurs in interphase nuclei and competes for binding POGZ. Interacts with POGZ; the interaction competes for interaction with CBX5. Interacts with SETDB1; the interaction is enhanced by KAP1 sumoylation, stimulates SETDB1 histone methyltransferase activity and gene silencing. Interacts (via the PHD-type zinc finger) with UBE2I; the interaction is required for sumoylation and repressor activity. Component of the TRIM28/KAP1-ERBB4-MDM2 complex involved in connecting growth factor and DNA damage responses. Interacts directly with ERBB4; the interaction represses ERBB4-mediated transcription activity. Interacts with MDM2; the interaction contributes to p53/TP53 inactivation. Component of the TRIM28/KAP1-MDM2-p53/TP53; involved in regulating p53/TP53 stabilization and activity. Interacts (via the leucine zipper alpha helical coiled-coil) with E2F1 (central region); the interaction inhibits E2F1 acetylation and transcriptional activity. Interacts with PPP1CA; the interaction dephosphorylates TRIM28 at Ser-824 and forms a complex at the p21 promoter site. Interacts with PPP1CB; the interaction is weak but is increased on dephosphorylation at Ser-824. Interacts with SMARCAD1. Interacts with, and sumoylates IRF7. Interacts with MAGEC2. Part of a complex composed of TRIM28, HDAC1, HDAC2 and EHMT2. Intera…
messages: Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation…
messages: Nucleus
messages: Sumoylation/desumoylation events regulate TRIM28-mediated transcriptional repression. Sumoylation is required for interaction with CHD3 and SETDB1 and the corepressor activity. Represses and is repressed by Ser-824 phosphorylation. Enhances the TRIM28 corepressor activity, inhibiting transcriptional activity of a number of genes including GADD45A and CDKN1A/p21. Lys-555, Lys-780 and Lys-805 are the major sites of sumoylation. In response to Dox-induced DNA damage, enhanced phosphorylation on Ser-825 prevents sumoylation and allows de-repression of CDKN1A/p21.
messages: The HP1 box is both necessary and sufficient for HP1 binding.
messages: The PHD-type zinc finger enhances CEBPB transcriptional activity. The PHD-type zinc finger, the HP1 box and the bromo domain, function together to assemble the machinery required for repression of KRAB domain-containing proteins. Acts as an intramolecular SUMO E3 ligase for autosumoylation of bromodomain.
messages: The RING-finger-B Box-coiled-coil/tripartite motif (RBCC/TRIM motif) is required for interaction with the KRAB domain of KRAB-zinc finger proteins. Binds four zinc ions per molecule. The RING finger and the N-terminal of the leucine zipper alpha helical coiled-coil region of RBCC are required for oligomerization.

10116:Ddb1
gene id: 10116:Ddb1
uniprot id: A6I047
uniprot id: G3V8T4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDB1 family.
messages: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.
messages: Component of the UV-DDB complex.
messages: Nucleus
messages: The core of the protein consists of three WD40 beta-propeller domains.

10116:Adcy9
gene id: 10116:Adcy9
uniprot id: M0R5U4
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

10116:Inhbc
gene id: 10116:Inhbc
uniprot id: A6HQV4
uniprot id: Q9WUK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity).
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

10116:Lamc3
gene id: 10116:Lamc3
uniprot id: A0A0G2K023
uniprot id: A6JU33
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

10116:Lca5l
gene id: 10116:Lca5l
uniprot id: A0A8I6A3I7
names: Similarity
messages: Belongs to the LCA5 family.

10116:Trim55
gene id: 10116:Trim55
uniprot id: Q5PQN5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homooligomer and heterooligomer (Probable). Interacts with titin/TTN. Interacts with myosins. Interacts with SQSTM1 and NBR1. Probably interacts with TRIM63 and TRIM54 (By similarity).
messages: May regulate gene expression and protein turnover in muscle cells.
messages: Nucleus

10116:Slain2
gene id: 10116:Slain2
uniprot id: A0A8I6AIE0
uniprot id: A6JD58
uniprot id: G3V6A2
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

10116:Dnaaf6
gene id: 10116:Dnaaf6
uniprot id: Q4V8B6
names: Similarity
messages: Belongs to the PIH1 family.

10116:Tmem53
gene id: 10116:Tmem53
uniprot id: A0A8I6G340
uniprot id: A6JZD3
uniprot id: D3ZPB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

10116:Olr1006
gene id: 10116:Olr1006
uniprot id: D3ZH49
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Lalba
gene id: 10116:Lalba
uniprot id: P00714
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).
messages: Mammary gland specific. Secreted in milk.
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
messages: Secreted

10116:Tomm22
gene id: 10116:Tomm22
uniprot id: Q75Q41
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom22 family.
messages: Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (PubMed:19401463).
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOMM40 (By similarity). Interacts with PPP2R2B.
messages: Mitochondrion outer membrane
messages: The N-terminal domain (residues 1-60) is important for binding to the unfolded mature imported proteins. Residues (47-69) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 61-80) binds presequence of preproteins (By similarity). Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex.

10116:Oprl1
gene id: 10116:Oprl1
uniprot id: A6KLW2
uniprot id: A6KLW8
uniprot id: A6KLW9
uniprot id: F7FLX3
uniprot id: P35370
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
messages: Highly expressed in several brain areas, the intestine, liver and spleen. Detected in sympathetic stellate ganglion neurons.
messages: Membrane
messages: Phosphorylation at Ser-360 requires GRK3.
messages: Vesicle

10116:Sh3bp5
gene id: 10116:Sh3bp5
uniprot id: A6KFZ4
uniprot id: Q91Y80
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
messages: Interacts with BTK (PubMed:15158451). Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12 (PubMed:15158451). Interacts with GDP-bound and nucleotide-free forms of RAB11A (By similarity).
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: Mitochondrion
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

10116:Or5h26
gene id: 10116:Or5h26
uniprot id: A0A8I6GLG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Plcb2
gene id: 10116:Plcb2
uniprot id: O89040
names: Cofactor
names: Function
names: Miscellaneous
names: Subunit
names: Tissue Specificity
messages: Binds 1 Ca(2+) ion per subunit.
messages: Expressed in the gustatory cells of the circumvallate papillae. Not detected in non-sensory lingual epithelium, brain, parotid gland, liver, uterus, lung, heart, adrenal gland, ovary, spleen, pancreas, intestine, thymus, kidney or muscle.
messages: Interacts with RAC1 (By similarity). Forms a complex composed of at least WDR26, a G-beta:gamma unit, and PLCB2 (By similarity).
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This protein may be involved in the transduction of bitter taste stimuli.
messages: The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha-16.

10116:Traf3ip1
gene id: 10116:Traf3ip1
uniprot id: Q5XIN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAF3IP1 family.
messages: Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 (By similarity). Interacts with IL13RA1. Binds to microtubules, TRAF3 and DISC1 (By similarity). Interacts with MAP4 (By similarity).
messages: Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules (By similarity). Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity).
messages: cilium
messages: cilium axoneme
messages: cilium basal body
messages: cytoskeleton

10116:Hebp2
gene id: 10116:Hebp2
uniprot id: A6JPA3
uniprot id: D3ZHC4
names: Similarity
messages: Belongs to the HEBP family.

10116:Asb4
gene id: 10116:Asb4
uniprot id: Q6J757
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

10116:Smo
gene id: 10116:Smo
uniprot id: P97698
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: G protein-coupled receptor which associates with the patched protein (PTCH) to transduce hedgehog protein signaling. Binding of sonic hedgehog (SHH) to its receptor patched prevents inhibition of smoothened (SMO) by patched. When active, SMO binds to and sequesters protein kinase A catalytic subunit PRKACA at the cell membrane, preventing PRKACA-mediated phosphorylation of GLI transcription factors which releases the GLI proteins from PRKACA-mediated inhibition and allows for transcriptional activation of hedgehog pathway target genes. Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation.
messages: Homodimer. Interacts (via C-terminus) with protein kinase A catalytic subunit PRKACA; interacts with free PRKACA subunits and the interaction leads to sequestration of PRKACA at the membrane, preventing PRKACA-mediated phosphorylation of GLI transcription factors. Interacts with ARRB2. Interacts with KIF7. Interacts with BBS5 and BBS7; the interactions are indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO. Interacts with DLG5 and SDCBP. Interacts with GAS8/DRC4.
messages: In embryo, found in the early neural folds and neural tube, pre-somitic mesoderm and somites, developing limb bud, gut, eye, testes, cartilage, muscle, lung, epiglottis, thymus, tongue, jaw, taste buds, teeth, and skin. In adult, found in multiple tissues including heart, brain, liver, lung, skeletal muscle, kidney and testis.
messages: Phosphorylation by GRK kinases is required for interaction with protein kinase A catalytic subunit PRKACA.
messages: The N-terminal extracellular domain mediates sterol-binding which is required for maximal activation of signaling. Contains a second sterol-binding site within the seven-transmembrane pocket which is also required for activation. The activating sterol is likely to be cholesterol. The extracellular site is required for SHH-induced activity while the site within the transmembrane pocket regulates basal signaling in the absence of SHH.
messages: cilium

10116:Rabepk
gene id: 10116:Rabepk
uniprot id: Q4V8F4
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Endosome membrane
messages: Interacts with PIKFYVE; the interaction recruits RABEPK to the endosomal membrane. Interacts with RAB9 in its GTP-bound conformation.
messages: Phosphorylated on Ser residues by PIKFYVE.
messages: Rab9 effector required for endosome to trans-Golgi network (TGN) transport.

10116:RGD1359127
gene id: 10116:RGD1359127
uniprot id: Q6AY72
names: Similarity
messages: Belongs to the UPF0449 family.

10116:Septin10
gene id: 10116:Septin10
uniprot id: A6K3U3
uniprot id: Q5PQK1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).
messages: Filament-forming cytoskeletal GTPase.
messages: Proteolytically cleaved in vitro in a calmodulin-dependent manner.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with ADGB (By similarity).
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cytoskeleton
messages: flagellum

10116:Tsn
gene id: 10116:Tsn
uniprot id: Q71SY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

10116:P2ry14
gene id: 10116:P2ry14
uniprot id: A0A9K3Y832
uniprot id: O35881
uniprot id: Q5XIX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for UDP-glucose coupled to G-proteins.

10116:Slc10a7
gene id: 10116:Slc10a7
uniprot id: A6IYJ4
uniprot id: Q5PT50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Cell membrane
messages: Does not show transport activity towards bile acids or steroid sulfates.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis. Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate).
messages: Strongly expressed in liver, adrenal gland, small intestine and colon. Moderately expressed in heart, lung, kidney and spleen. Weakly expressed in brain.

10116:Snrpc
gene id: 10116:Snrpc
uniprot id: D3ZCL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA (By similarity). Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites (By similarity).
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus

10116:Ifi44
gene id: 10116:Ifi44
uniprot id: A6HWI9
uniprot id: B0BNB7
names: Similarity
messages: Belongs to the IFI44 family.

10116:Tnfsf4
gene id: 10116:Tnfsf4
uniprot id: A0A0U5JAD2
uniprot id: Q9Z2P3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production (By similarity).
messages: Detected in T-cell lines, but not in a macrophage cell line.
messages: Homotrimer.
messages: Membrane

10116:Tgm3
gene id: 10116:Tgm3
uniprot id: D4A5U3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by proteolytic processing. In vitro activation is commonly achieved by cleavage with dispase, a neutral bacterial protease. Physiological activation may be catalyzed by CTSL and, to a lesser extent, by CTSS (By similarity).
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 3 Ca(2+) cations per subunit. Binds 1 Ca(2+) as a zymogen, and binds 2 more Ca(2+) cations, or other divalent metal cations, after proteolytic processing.
messages: Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold. In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath (By similarity).
messages: Consists of two polypeptide chains, which are synthesized as a precursor form of a single polypeptide.
messages: Cytoplasm

10116:Ndufb7
gene id: 10116:Ndufb7
uniprot id: A6IYE2
uniprot id: D3ZLT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

10116:Tp63
gene id: 10116:Tp63
uniprot id: A6JRZ4
uniprot id: A6JRZ5
uniprot id: A6JRZ6
uniprot id: A6JRZ7
uniprot id: Q9JJP6
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
messages: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates RIPK4 transcription (By similarity). Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter (By similarity).
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
messages: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Interacts with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Interacts with WWP1. Interacts with PDS5A. Interacts (via activation domain) with NOC2L (By similarity).
messages: Cytoplasm
messages: May be sumoylated.
messages: Nucleus
messages: Produced by alternative promoter usage.
messages: Produced by alternative splicing of isoform 1.
messages: Produced by alternative splicing of isoform 2.
messages: Produced by alternative splicing of isoform 7.
messages: The transactivation inhibitory domain (TID) can interact with, and inhibit the activity of the N-terminal transcriptional activation domain of TA*-type isoforms.
messages: Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein (By similarity).
messages: Widely expressed, notably in thymus, prostate, placenta, and skeletal muscle, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast and prostate express high levels of DeltaN-type isoforms.

10116:Gast
gene id: 10116:Gast
uniprot id: P04563
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
messages: Secreted
messages: Sulfation on Tyr-87 enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins and between tissues (By similarity).

10116:Or4f56
gene id: 10116:Or4f56
uniprot id: A6HP34
uniprot id: D3ZII6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Slc39a1
gene id: 10116:Slc39a1
uniprot id: B5DEF5
names: Subcellular Location Annotation
messages: Membrane

10116:Zap70
gene id: 10116:Zap70
uniprot id: A0A0R4J8U1
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

10116:Crcp
gene id: 10116:Crcp
uniprot id: A6J0N3
uniprot id: Q8VHM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues (By similarity).
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Cell membrane
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts with POLR3H/RPC8. POLR3H/RPC8 and CRCP/RPC9 probably form a Pol III subcomplex (By similarity).
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
messages: Nucleus

10116:Ly49si2
gene id: 10116:Ly49si2
uniprot id: Q5MPP6
names: Subcellular Location Annotation
messages: Membrane

10116:Zc2hc1c
gene id: 10116:Zc2hc1c
uniprot id: Q6AYP4
names: Similarity
messages: Belongs to the ZC2HC1 family.

10116:Cpne5
gene id: 10116:Cpne5
uniprot id: A0A8I6A0U5
uniprot id: A0A8I6AER2
uniprot id: A6JJU1
uniprot id: D3ZGN2
names: Similarity
messages: Belongs to the copine family.

10116:Taf9b
gene id: 10116:Taf9b
uniprot id: Q62880
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF9 family.
messages: Binds TAF5 and TAF6. Component of TFIID and the TATA-binding protein-free TAF complex (TFTC). TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Binds N-terminal domain of p53/TP53 which is essential for transcription (By similarity).
messages: By apoptotic signals in PC12 cells.
messages: Essential for cell viability. TAF9 and TAF9L are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity).
messages: Nucleus

10116:Gpr52
gene id: 10116:Gpr52
uniprot id: A0A8I5ZQK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

10116:Gfra1
gene id: 10116:Gfra1
uniprot id: A6JI55
uniprot id: A6JI56
uniprot id: A6JI59
uniprot id: Q62997
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET (PubMed:15044950). Interacts with RET (By similarity). Interacts with SORL1, either alone or in complex with GDNF. Interaction between SORL1 and GFRA1 leads to GFRA1 internalization, but not degradation (By similarity).
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Endosome
messages: Expressed in liver, brain, kidney and cochlea.
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.
messages: multivesicular body
messages: trans-Golgi network

10116:Abracl
gene id: 10116:Abracl
uniprot id: A6JP93
names: Similarity
messages: Belongs to the costars family.

10116:Dmrtc2
gene id: 10116:Dmrtc2
uniprot id: A6J915
uniprot id: D3ZH91
uniprot id: M0RDV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

10116:Sema3b
gene id: 10116:Sema3b
uniprot id: D3ZHJ3
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Cenpc
gene id: 10116:Cenpc
uniprot id: Q66LH7
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

10116:Slc36a3
gene id: 10116:Slc36a3
uniprot id: Q4V8B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Membrane

10116:Edc4
gene id: 10116:Edc4
uniprot id: Q3ZAV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat EDC4 family.
messages: In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro).
messages: Nucleus
messages: P-body
messages: Part of a decapping complex consisting of DCP1A, DCP2, EDC3, EDC4 and probably DDX6. Part of a complex consisting of DCP1A, EDC3, EDC4 and DDX6. Part of a complex consisting of DCP1B, EDC3, EDC4 and DDX6. Interacts with DCP2. Interacts with NBDY. Interacts with Tex19.1 (By similarity). Interacts with LSM14A (By similarity). Interacts with DDX6 (By similarity).

10116:Sox9
gene id: 10116:Sox9
uniprot id: F1LYL9
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated; acetylation impairs nuclear localization and ability to transactivate expression of target genes. Deacetylated by SIRT1.
messages: Homodimer; homodimerization is required for activity. Interacts (via C-terminus) with ZNF219; forming a complex that binds to the COL2A1 promoter and activates COL2A1 expression (By similarity). Interacts with DDRGK1. Interacts with EP300/p300 (By similarity). Interacts with beta-catenin (CTNNB1); inhibiting CTNNB1 activity by competing with the binding sites of TCF/LEF within CTNNB1 (By similarity).
messages: Nucleus
messages: Phosphorylation at Ser-64 and Ser-211 by PKA increases transcriptional activity and may help delay chondrocyte maturation downstream of PTHLH/PTHrP signaling. Phosphorylation at either Ser-64 or Ser-211 is required for sumoylation, but phosphorylation is not dependent on sumoylation. Phosphorylated on tyrosine residues; tyrosine dephosphorylation by PTPN11/SHP2 blocks SOX9 phosphorylation by PKA and subsequent SUMOylation.
messages: Sumoylated; phosphorylation at either Ser-64 or Ser-211 is required for sumoylation. Sumoylation is induced by BMP signaling pathway.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: The PQA region (for proline, glutamine and alanine-rich) helps stabilize SOX9 and facilitates transactivation. It lacks intrinsic transactivation capability.
messages: The transactivation domains TAM and TAC (for transactivation domain in the middle and at the C-terminus, respectively) are required to contact transcriptional coactivators and basal transcriptional machinery components and thereby induce gene transactivation.
messages: Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (By similarity). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6 (PubMed:26150426). Also binds to some promoter regions (By similarity). Plays a central role in successive steps of chondrocyte differentiation (By similarity). Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression (By similarity). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C (By similarity). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes (By similarity). Acts in cooperation with the Hedgehog p…
messages: Ubiquitinated; ubiquitination leads to proteasomal degradation and is negatively regulated by DDRGK1.

10116:Abca4
gene id: 10116:Abca4
uniprot id: A6HVF7
names: Subcellular Location Annotation
messages: Membrane

10116:Cdca3
gene id: 10116:Cdca3
uniprot id: Q68FW2
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity).
messages: Interacts with SKP1. Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity).
messages: The KEN box is required for the association with the APC/C-Cdh1 complex.
messages: Ubiquitinated and degraded by the APC/C-Cdh1 complex.
messages: cytosol

10116:Ebpl
gene id: 10116:Ebpl
uniprot id: A6K6B7
uniprot id: D3ZXC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:Clcn2
gene id: 10116:Clcn2
uniprot id: A0A0A0MXT6
uniprot id: A6JS86
uniprot id: P35525
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.
messages: Cell membrane
messages: Membrane
messages: Phosphorylated. Activated by dephosphorylation.
messages: The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (By similarity).
messages: Ubiquitously expressed.
messages: Voltage-gated chloride channel (PubMed:1311421, PubMed:12163466). Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport (PubMed:1311421). Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (By similarity).

10116:Dock8
gene id: 10116:Dock8
uniprot id: F1LPG2
names: Similarity
messages: Belongs to the DOCK family.

10116:Atpsckmt
gene id: 10116:Atpsckmt
uniprot id: D3ZLY0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Contains an atypical, non-cleavable mitochondrial targeting sequence responsible for its localization to mitochondria.
messages: Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration (Probable). Promotes chronic pain. Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (By similarity).
messages: Mitochondrion membrane

10116:Ticam1
gene id: 10116:Ticam1
uniprot id: A0A8I5Y6Z3
uniprot id: M0RA08
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1.
messages: Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.
messages: Mitochondrion
messages: The N-terminal region is essential for activation of the IFNB promoter activity.
messages: autophagosome
messages: cytosol

10116:Mtor
gene id: 10116:Mtor
uniprot id: A6IU70
uniprot id: P42346
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylates when part of mTORC1 or mTORC2 (By similarity). Phosphorylation at Ser-1261, Ser-2159 and Thr-2164 promotes autophosphorylation (By similarity). Phosphorylation in the kinase domain modulates the interactions of MTOR with RPTOR and AKT1S1/PRAS40 and leads to increased intrinsic mTORC1 kinase activity (By similarity). Phosphorylation at Ser-2159 by TBK1 in response to growth factors and pathogen recognition receptors promotes mTORC1 activity (By similarity). Phosphorylation at Thr-2173 in the ATP-binding region by AKT1 strongly reduces kinase activity (By similarity).
messages: Belongs to the PI3/PI4-kinase family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lysosome membrane
messages: Microsome membrane
messages: Mitochondrion outer membrane
messages: Nucleus
messages: PML body
messages: Part of the mechanistic target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8 and RPTOR. The mTORC1 complex is a 1 Md obligate dimer of two stoichiometric heterotetramers with overall dimensions of 290 A x 210 A x 135 A. It has a rhomboid shape and a central cavity, the dimeric interfaces are formed by interlocking interactions between the two MTOR and the two RPTOR subunits. The MLST8 subunit forms distal foot-like protuberances, and contacts only one MTOR within the complex, while the small AKT1S1/PRAS40 localizes to the midsection of the central core, in close proximity to RPTOR. mTORC1 associates with AKT1S1/PRAS40, which inhibits its activity by blocking MTOR substrate-recruitment site. Part of the mechanistic target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR (By similarity). Interacts with PLPP7 and PML (By similarity). Interacts with PRR5 and RICTOR; the interaction is direct within the mTORC2 complex and interaction with RICTOR is enhanced by deubiquitination of RICTOR by USP9X. mTORC1 and mTORC2 associate with DEPTOR, which regulates its activity. Interacts with WAC; WAC positively regulates MTOR activity by promoting the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex which leads to the dimerization of the mTORC1 complex and its subsequent activation. Interacts with UBQLN1. Interacts with TTI1 and TELO2. Interacts with CLIP1; phosphorylates and regulates CLIP1. Interacts with NBN. Interacts with HTR6. Interacts with BRAT1. Interacts with MEAK7 (via C-terminal domain); the interaction increases upon nutrient stimulation. Interacts with TM4SF5; the interaction is positively regulated by arginine and is negatively regulated by leucine. Interacts with GPR137B. Interacts with NCKAP1L. Interacts with TPCN1 and TPCN2; the interaction is required for TPCN1 and TPCN2 sensitivity to ATP (By similarity). Interacts w…
messages: Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (By similarity). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (By similarity). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:9465032). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (By similarity). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (By similarity). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (By similarity). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (By similarity). To maintain …
messages: The FAT domain forms three discontinuous subdomains of alpha-helical TPR repeats plus a single subdomain of HEAT repeats. The four domains pack sequentially to form a C-shaped a-solenoid that clamps onto the kinase domain (By similarity).
messages: The kinase domain (PI3K/PI4K) is intrinsically active but has a highly restricted catalytic center.
messages: The mTORC1 complex is activated in response to nutrients, growth factors or amino acids: activation requires relocalization of the mTORC1 complex to lysosomes that is mediated by the Ragulator complex, SLC38A9, and the Rag GTPases RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and RagD/RRAGD. Activation of mTORC1 by growth factors such as insulin involves AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase a potent activator of the protein kinase activity of mTORC1. Insulin-stimulated and amino acid-dependent phosphorylation at Ser-1261 promotes autophosphorylation and the activation of mTORC1. On the other hand, low cellular energy levels can inhibit mTORC1 through activation of PRKAA1 while hypoxia inhibits mTORC1 through a REDD1-dependent mechanism which may also require PRKAA1. The kinase activity of MTOR within the mTORC1 complex is positively regulated by MLST8. The kinase activity of MTOR is inhibited by DEPTOR and AKT1S1. The non-canonical mTORC1 complex is independent of the RHEB GTPase and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3 but not other mTORC1 substrates: it is activated by FLCN, which activates Rag GTPases RagC/RRAGC and RagD/RRAGD. MTOR is the target of the immunosuppressive and anti-cancer drug rapamycin which acts in complex with FKBP1A/FKBP12, and specifically inhibits its kinase activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 may also be regulated by RHEB but in an indirect manner through the PI3K signaling pathway.
messages: phagosome

10116:Gpr132
gene id: 10116:Gpr132
uniprot id: A0A8I6A964
uniprot id: A6KBW8
uniprot id: D3ZIH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

10116:Rpp40
gene id: 10116:Rpp40
uniprot id: Q5BK64
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: nucleolus

10116:Fgf1
gene id: 10116:Fgf1
uniprot id: A0A7U3JW64
uniprot id: P61149
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: In the nucleus, phosphorylated by PKC/PRKCD.
messages: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13 (By similarity). Interacts with LRRC59 (By similarity). Interacts with CSNKA, CSNKB and FIBP (By similarity). While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1. Forms a ternary complex with FGFR1 and ITGAV:ITGB3 and induces the recruitment of PTPN11 to the complex (By similarity).
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

10116:Rab38
gene id: 10116:Rab38
uniprot id: F7F483
uniprot id: Q63483
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

10116:Polr1e
gene id: 10116:Polr1e
uniprot id: A0A9K3Y7A9
uniprot id: B0BN64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

10116:Kiss1r
gene id: 10116:Kiss1r
uniprot id: A0A0G2JSL6
uniprot id: A6K8U8
uniprot id: Q924U1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expression detected in trophoblast giant cells (TGCs), the placenta-derived cell lineage aligned at the boundary between the uterus and placenta, at embryonic days 12.5 (12.5 dpc). However, expression is faint and only observed in some of these cells, and disappears by 15.5 dpc.
messages: Highest expression levels in the cerebrum and cecum. Moderate expression in the ovary, colon and placenta. Low levels in the uterus, small intestine, and thymus. Expressed only moderately in the placenta. No expression in kidney tissues. Has a complex and abundant central nervous system expression pattern. Expressed in brain regions such as pons, midbrain, thalamus, hypothalamus, hippocampus, amygdala, cortex, frontal cortex, and striatum. No expression in the cerebellum. Persistent expression is detected in hypothalamus throughout postnatal development, with maximum expression levels at puberty in both male and female. Hypothalamic expression changed throughout the estrus cycle and is significantly increased after gonadectomy, a rise that is prevented by sex steroid replacement both in males and females.
messages: Membrane
messages: Receptor for metastin, a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.

10116:Tbc1d14
gene id: 10116:Tbc1d14
uniprot id: Q5CD77
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: First detected in the testis at 5 weeks. Level of expression increases up to 7 weeks and maintains even at 63 weeks.
messages: Interacts with ULK1. May interact with RAB11A and RAB11B, but does not exhibit any GTPase-activating activity toward these proteins. Interacts with TRAPPC8.
messages: Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy.
messages: PubMed:15758561 detected expression at the stage of sexual maturation in testis, mainly in the spermatocytes. No expression detected in the ovary, brain, heart, lung, liver and kidney. PubMed:15200410 detected expression in brain, heart, lung, liver, spleen and kidney but not in small intestine.
messages: Up-regulated in nephrectomized kidney.
messages: cis-Golgi network
messages: trans-Golgi network

10116:Cyp51
gene id: 10116:Cyp51
uniprot id: A6K271
uniprot id: Q64654
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Inhibited by azalanstat (PubMed:7665087). Inhibited by azole antifungal agents ketoconazole, itraconazole and fluconazole (PubMed:10544287).
messages: Microsome membrane
messages: Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis (PubMed:7665087, PubMed:10544287). Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of sterols such as lanosterol (lanosta-8,24-dien-3beta-ol) and 24,25-dihydrolanosterol (DHL) in the form of formate, and converts the sterols to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol and 4,4-dimethyl-8,14-cholestadien-3beta-ol, respectively, which are intermediates of cholesterol biosynthesis (PubMed:7665087, PubMed:10544287, PubMed:11328599, PubMed:3782148, PubMed:1872829). Can also demethylate substrates not intrinsic to mammals, such as eburicol (24-methylene-24,25-dihydrolanosterol), but at a lower rate than DHL (PubMed:1872829).

10116:Cartpt
gene id: 10116:Cartpt
uniprot id: A6I575
uniprot id: P49192
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CART family.
messages: By cocaine and amphetamine.
messages: Neuroendocrine tissues. Predominantly expressed in the hypothalamus, pituitary, and longitudinal muscle-myenteric plexus. Abundant expression is also seen in the midbrain/thalamus and eye. A lower level expression is seen in the other brain regions and adrenal.
messages: Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus.
messages: Secreted

10116:Abhd10
gene id: 10116:Abhd10
uniprot id: Q5I0K5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability. Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate.
messages: Belongs to the AB hydrolase superfamily.
messages: Expressed in epididymal sperm but not in testicular sperm (at protein level).
messages: Inhibited by palmostatin-B.
messages: Mitochondrion

10116:Actg2
gene id: 10116:Actg2
uniprot id: A6IAN1
uniprot id: P63269
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-74 by SETD3.
messages: Monomethylation at Lys-85 (K85me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
messages: N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP.
messages: Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
messages: cytoskeleton

10116:Kcnq2
gene id: 10116:Kcnq2
uniprot id: A0A8I5ZWG8
uniprot id: O88943
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2 current is blocked by barium and tetraethylammonium whereas 4-aminopyridine and charybdotoxin have no effect on KCNQ2 current. Tyrosine kinase inhibitors genistein or herbimycin a markedly down-regulate KCNQ2 current. As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:11038262, PubMed:11230508). KCNQ2-KCNQ3 channel is selectively permeable to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). Associates with Na(+)-coupled myo-inositol symporter SLC5A3 forming a coregulatory complex that alters ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (By similarity).
messages: Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.2/KCNQ2 sub-subfamily.
messages: Cell membrane
messages: Expressed in brain and sympathetic ganglia. In brain, expressed in cortex, hippocampus, and cerebellum. In sympathetic ganglia, expressed at lower levels in celiac ganglia and superior mesenteric ganglia than in superior cervical ganglia.
messages: Heterotetramer with KCNQ3; form the heterotetrameric M potassium channel (PubMed:11230508). Interacts with calmodulin; the interaction is calcium-independent, constitutive and participates in the proper assembly of a functional heterotetrameric M channel. May associate with KCNE2 (By similarity). Interacts with IQCJ-SCHIP1 (By similarity). Interacts (via the pore module) with SLC5A3; forms a coregulatory complex that alters ion selectivity, voltage dependence and gating kinetics of the channel.
messages: KCNQ2/KCNQ3 are ubiquitinated by NEDD4L. Ubiquitination leads to protein degradation. Degradation induced by NEDD4L is inhibited by USP36.
messages: KCNQ2/KCNQ3 heteromeric current can be increased by intracellular cyclic AMP, an effect that depends on phosphorylation of Ser-52 in the N-terminal region.
messages: Membrane
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
messages: When coexpressed with KCNQ3 subunit in CHO cells or Xenopus oocytes, isoform B was found to have significantly different deactivation-activation kinetics. The kinetics was 2.5 times more slowly than the kinetics of other isoforms. The presence of exon 15a in isoform B accounts for the slow deactivation-activation kinetics. Alternative splicing of the KCNQ2 gene may contribute to the variation in M-current kinetics seen in vivo.

10116:Or2ag19b
gene id: 10116:Or2ag19b
uniprot id: A0A8I6AJW7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Pcyox1
gene id: 10116:Pcyox1
uniprot id: A6IAW5
uniprot id: Q99ML5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the prenylcysteine oxidase family.
messages: Expressed mainly in cerebrum.
messages: Lysosome
messages: Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (By similarity). Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides (By similarity). Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded (By similarity).

10116:Adgre1
gene id: 10116:Adgre1
uniprot id: A0A8I5ZYF2
uniprot id: A6KQQ5
uniprot id: Q5Y4N8
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRE1 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain.
messages: Orphan receptor involved in cell adhesion and probably in cell-cell interactions involved specifically cells of the immune system. May play a role in regulatory T-cells (Treg) development.

10116:Ciao1
gene id: 10116:Ciao1
uniprot id: A6HQ07
uniprot id: Q5M7T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Component of the CIA complex. Interacts with CIAO2A and forms a complex with CIAO2B and MMS19; the interactions with CIAO2A and CIAO2B are mutually exclusive. Interacts with CHD1L, ERCC2, IREB2 and POLD1. Component of the MMXD complex, which includes CIAO1, ERCC2, CIAO2B, MMS19 and SLC25A5. Interacts with WT1. Interacts with CIAO3. Interacts (via LYR motif) with HSC20.
messages: Cytoplasm
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (By similarity). Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity).
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

10116:Itga2
gene id: 10116:Itga2
uniprot id: A0A0G2K470
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

10116:Or14a257
gene id: 10116:Or14a257
uniprot id: D4AAQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Slc52a3
gene id: 10116:Slc52a3
uniprot id: A6KHL8
uniprot id: G3V6N3
uniprot id: Q4FZU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.
messages: Predominantly expressed in small intestine. Highly expressed in jejunum and ileum. Also expressed in testis and at lower level in lung, kidney, stomach and colon.

10116:Klhdc2
gene id: 10116:Klhdc2
uniprot id: Q3KRE6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter KLHDC2. Interacts with CREB3; interaction is direct and specific as it does not interact with CREB1, ATF4, ATF6, JUN, FOS, CEBPA or herpes simplex virus transactivator VP16.
messages: Nucleus
messages: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC2) complex specifically recognizes proteins with a diglycine (Gly-Gly) at the C-terminus, leading to their ubiquitination and degradation. The CRL2(KLHDC2) complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine. The CRL2(KLHDC2) complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation. May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding.

10116:Asgr2
gene id: 10116:Asgr2
uniprot id: P08290
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Calcium is required for ligand binding.
messages: Expressed exclusively in hepatic parenchymal cells.
messages: Interacts with LASS2.
messages: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
messages: Membrane
messages: Two types of rat hepatic lectin have been identified, RHL-1 and RHL-2/3, having a relative abundance of 4:1. RHL-2 and RHL-3 only differs in their carbohydrate structures.

10116:Cpt1c
gene id: 10116:Cpt1c
uniprot id: A0A8L2QGW1
uniprot id: A6JAU6
uniprot id: F1LN46
uniprot id: Q3KR63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Endoplasmic reticulum
messages: Expressed in brain (at protein level).
messages: May play a role in lipid metabolic process.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including CPT1C. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing. Interacts with ATL1 (By similarity).
messages: Synapse
messages: axon
messages: dendrite

10116:Ywhaz
gene id: 10116:Ywhaz
uniprot id: A6HR34
uniprot id: P63102
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (By similarity). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (By similarity). Binding generally results in the modulation of the activity of the binding partner (By similarity). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (By similarity). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (PubMed:16959763).
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Highly expressed in brain (at protein level).
messages: Homodimer. Heterodimerizes with YWHAE (By similarity). Homo- and heterodimerization is inhibited by phosphorylation on Ser-58 (By similarity). Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with CDK16 and with WEE1 (C-terminal). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with Thr-phosphorylated ITGB2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization (By similarity). Interacts with GAB2 and SAMSN1. Binds to TLK2 (By similarity). Interacts with BSPRY. Interacts with BCL2L11. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with ZFP36L1 (via phosphorylated form); this interaction occurs in a p38 MAPK- and AKT-signaling pathways (By similarity). Interacts with SLITRK1 (By similarity). Interacts with AK5, LDB1, MADD, MARK3, PDE1A and SMARCB1 (By similarity). Interacts with YWHAZ (By similarity). Interacts with MEFV (By similarity). Interacts with ADAM22 (via C-terminus) (By similarity).
messages: Melanosome
messages: The delta, brain-specific form differs from the zeta form in being phosphorylated. Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Thr-232; inhibits binding of RAF1. Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53.

10116:Septin12
gene id: 10116:Septin12
uniprot id: A6K4P8
uniprot id: Q4V8G5
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins. Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity).
messages: In developing testis, expression increases steadily until sexual maturity (approximately 49 days postpartum) where it remains expressed at a relatively constant level.
messages: Predominantly expressed in testis and epididymis. Component of the sperm tail annulus (at protein level).
messages: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPTIN6 and SEPTIN11. Self-associates. Component of a octameric complex consisting of SEPTIN12, SEPTIN7, SEPTIN6 and SEPTIN2 or SEPTIN4 in the order 12-7-6-2-2-6-7-12 or 12-7-6-4-4-6-7-12 and located in the sperm annulus; the octamer polymerizes into filaments via the SEPTIN12 N- and C-termini; the SEPTIN12:SEPTIN7 association is mediated by the GTP-binding domains. Interacts with SPAG4 and LMNB1. Associates with alpha- and beta-tubulins (By similarity).
messages: cytoskeleton
messages: flagellum
messages: spindle

10116:Slc20a1
gene id: 10116:Slc20a1
uniprot id: A6HQ55
uniprot id: Q9JJP0
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: By 1,25-dihydroxyvitamin D3 and phosphate deprivation.
messages: Cell membrane
messages: Membrane
messages: Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:9528951). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (By similarity). Essential for cell proliferation but this function is independent of its phosphate transporter activity (By similarity).
messages: Sodium-phosphate symporter.
messages: Ubiquitously expressed.

10116:Sppl2b
gene id: 10116:Sppl2b
uniprot id: A0A8L2R960
uniprot id: A6K8E3
uniprot id: Q5PQL3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22B family.
messages: Cell membrane
messages: Endosome membrane
messages: Glycosylated.
messages: Golgi apparatus membrane
messages: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity.
messages: Lysosome membrane
messages: Membrane
messages: Monomer. Homodimer. Interacts with ITM2B and TNF.
messages: The PAL motif is required for normal active site conformation. The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP.

10116:Kcnc1
gene id: 10116:Kcnc1
uniprot id: P25122
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily.
messages: Cell membrane
messages: Expressed in brain (PubMed:1378392). Expressed in globus pallidal neurons of the basal ganglia (at protein level) (PubMed:10482766). Detected on Purkinje cells in the cerebellum molecular layer (at protein level) (PubMed:20857303).
messages: Heteromultimer with KCNG3, KCNG4 and KCNV2 (By similarity). Heteromultimer with KCNC2 (PubMed:10482766, PubMed:14679187). Heterotetramer with KCNC3 (By similarity). Interacts with the ancillary subunits KCNE1 and KCNE2; the interaction modulates channel activity (PubMed:14679187).
messages: N-glycosylated; contains sialylated glycans.
messages: Presynaptic cell membrane
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
messages: The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
messages: Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10482766, PubMed:14679187). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well (PubMed:10482766, PubMed:14679187). Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons (PubMed:10482766).
messages: axon

10116:Gon4l
gene id: 10116:Gon4l
uniprot id: A0A0G2K0W6
uniprot id: Q535K8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Found in a complex with YY1, SIN3A and HDAC1.
messages: Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis.
messages: Nucleus

10116:Loxl3
gene id: 10116:Loxl3
uniprot id: A6IAI6
uniprot id: D3ZP82
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

10116:Vom2r10
gene id: 10116:Vom2r10
uniprot id: D4A741
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Dusp1
gene id: 10116:Dusp1
uniprot id: A6HDE4
uniprot id: Q63683
uniprot id: Q64623
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Brain. High level expression seen in the cingulate gyrus within the retrospinal cortex, ventral and medial divisions of the anterior thalamus and the medial geniculate nucleus. Expressed at moderate levels in the parietal and temporal cortex. Expressed in the cerebellum.
messages: Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
messages: Exhibits night/day variations with a 100-fold increased expression at night in the pineal gland (at protein level). Up-regulation is due to a large degree to the release of norepinephrine from nerve terminals in the pineal gland and cAMP signaling pathway.
messages: Nucleus
messages: Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.

10116:Birc2
gene id: 10116:Birc2
uniprot id: A0A9K3Y7W9
uniprot id: Q6P6S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

10116:Grm8
gene id: 10116:Grm8
uniprot id: A6IEA3
uniprot id: F1LRA6
uniprot id: P70579
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with PICK1.
messages: Membrane
messages: Prominent expression in olfactory bulb, pontine gray, lateral reticular nucleus of the thalamus, and piriform cortex. Less abundant expression incerebral cortex, hippocampus, cerebellum, and mammillary body.

10116:Mid1
gene id: 10116:Mid1
uniprot id: A6K2D8
uniprot id: P82458
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
messages: Homodimer or heterodimer with MID2. Interacts with IGBP1.
messages: cytoskeleton

10116:Fam219b
gene id: 10116:Fam219b
uniprot id: A0A0G2JWV6
uniprot id: A6J4V8
names: Similarity
messages: Belongs to the FAM219 family.

10116:Arfgap2
gene id: 10116:Arfgap2
uniprot id: Q3MID3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). May regulate coatomer-mediated protein transport from the Golgi complex to the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity).
messages: Golgi apparatus membrane
messages: Interacts with the coatomer complex. Interacts with the C-terminal appendage domain of COPG1 (By similarity).

10116:Ppip5k1
gene id: 10116:Ppip5k1
uniprot id: A0A0G2K4M9
uniprot id: A0A8I6AB72
uniprot id: A0A8I6AQ26
uniprot id: A0A8I6AVA5
uniprot id: F1LSW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

10116:Szrd1
gene id: 10116:Szrd1
uniprot id: A6ITR5
uniprot id: Q5XIA2
names: Similarity
messages: Belongs to the SZRD1 family.

10116:Hs3st2
gene id: 10116:Hs3st2
uniprot id: A6I8U4
uniprot id: Q80W66
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by light stimulation at night through the suppression of beta-adrenergic signaling.
messages: Belongs to the sulfotransferase 1 family.
messages: Golgi apparatus membrane
messages: Highly expressed in the brain, in the pineal gland specifically during the daylight hours, and weakly in the olfactory bulb and pineal gland during the night. First detected between postnatal days 5 and 10.
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). May contribute to the pineal circadian physiology (PubMed:12601002).

10116:Hadhb
gene id: 10116:Hadhb
uniprot id: A6HAE3
uniprot id: Q60587
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Endoplasmic reticulum
messages: Heterotetramer of 2 alpha/HADHA and 2 beta/HADHB subunits; forms the mitochondrial trifunctional enzyme (By similarity). Also purified as higher order heterooligomers including a 4 alpha/HADHA and 4 beta/HADHB heterooligomer which physiological significance remains unclear (PubMed:1730633). The mitochondrial trifunctional enzyme interacts with MTLN (By similarity). Interacts with RSAD2/viperin (By similarity).
messages: Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

10116:Itpa
gene id: 10116:Itpa
uniprot id: D3ZW55
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

10116:Zfp280c
gene id: 10116:Zfp280c
uniprot id: A0A8I6A8B8
uniprot id: D3ZZ25
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

10116:Oser1
gene id: 10116:Oser1
uniprot id: Q703I1
names: Induction
names: Tissue Specificity
messages: Expressed in testis, unpreganant uterus and cardiac myocytes.
messages: Ubiquitous with high level in testis, placenta and cardiac myocytes.
messages: Up-regulated by DNA damaging agents like H(2)O(2) in cardiac myocytes.

10116:C1qtnf5
gene id: 10116:C1qtnf5
uniprot id: A0A3B0ITJ1
uniprot id: Q5FVH0
names: Subcellular Location Annotation
names: Subunit
messages: Homotrimer (via collagen-like domain). May form higher order oligomers by supercoiling of the trimers. May interact with ERFE (By similarity).
messages: Secreted

10116:Vom2r80
gene id: 10116:Vom2r80
uniprot id: A0A8I5Y009
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Mt3
gene id: 10116:Mt3
uniprot id: A6JY74
uniprot id: P37361
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity).
messages: Brain.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

10116:Gfm2
gene id: 10116:Gfm2
uniprot id: A0A0G2K1R1
uniprot id: A0A8I6A4R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

10116:Atf1
gene id: 10116:Atf1
uniprot id: A6KCI3
uniprot id: F7FD47
uniprot id: Q5BK34
names: Subcellular Location Annotation
messages: Nucleus

10116:Hscb
gene id: 10116:Hscb
uniprot id: A0A8I5ZYF5
uniprot id: A6J288
uniprot id: D3ZME7
names: Similarity
messages: Belongs to the HscB family.

10116:Itsn1
gene id: 10116:Itsn1
uniprot id: Q9WVE9
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin-coated vesicles (PubMed:20448150). Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (By similarity). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines (By similarity). Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (PubMed:23633571). Inhibits ARHGAP31 activity toward RAC1 (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Detected in brain, spleen, lung, liver and heart (at protein level). Ubiquitous. Detected in brain, spleen, lung, liver, skeletal muscle and kidney.
messages: Endomembrane system
messages: Endosome
messages: In an autoinhibited form the SH3 domain 5 may bind intramolecularly to the DH domain, thus blocking the CDC42-binding site.
messages: Interacts (via DH domain) with CDC42. Interacts (via SH3 domain 1) with WASL (By similarity). Interacts with dynamin, SNAP25 and SNAP23 (PubMed:10373452). Interacts with clathrin-associated proteins and other components of the endocytic machinery, such as SPIN90, EPS15, EPN1, EPN2, STON2, FCHO1, FCHO2 and DAB2 (PubMed:20448150). Interacts (via SH3 domains) with REPS1 and SGIP1. Interacts with ARHGAP31. Interacts with ADAM15 (By similarity). Interacts with PRRT2 (PubMed:26797119). Interacts (via SH3 domain 4) with FCHSD2 (via SH3 domain 2). Interacts (via SH3 domain 1) with DENND2B (By similarity). Interacts (via SH3 domains) with CBL (By similarity). Isoform 2: Interacts with CBL and DNM1. Isoform 2: Interacts with LMNA. Isoform 2: Interacts with importin subunit KPNA1; this is likely to mediate its import into the nucleus (By similarity).
messages: Nucleus envelope
messages: Plays a role in synaptic vesicle endocytosis in brain neurons.
messages: Recycling endosome
messages: SH3-1 and SH3-4 bind to ARHGAP31 (By similarity). SH3-3, SH3-4 and SH3-5, but not SH3-1 and SH3-2 domains, bind to dynamin.
messages: The KLERQ domain binds to SNAP-25 and SNAP-23.
messages: clathrin-coated pit
messages: lamellipodium
messages: synaptosome

10116:Msto1
gene id: 10116:Msto1
uniprot id: A6J6B0
uniprot id: D3ZMW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the misato family.
messages: Mitochondrion outer membrane

10116:Epha3
gene id: 10116:Epha3
uniprot id: A0A0G2JT71
uniprot id: O08680
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-603 mediates interaction with NCK1. Dephosphorylated by PTPN1 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
messages: Cell membrane
messages: Down-regulated by IL1-beta in neonatal cardiac myocytes.
messages: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function. Interacts (phosphorylated) with PTPN1; dephosphorylates EPHA3 and may regulate its trafficking and function. Interacts (phosphorylated) with CRK; mediates EFNA5-EPHA3 signaling through RHOA GTPase activation. Interacts with NCK1 (via SH2 domain); mediates EFNA5-EPHA3 signaling (By similarity).
messages: Membrane
messages: Most abundant in the heart, brain and lung.
messages: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development (By similarity).

10116:Gucy1a1
gene id: 10116:Gucy1a1
uniprot id: A6J5U0
uniprot id: F7ESJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

10116:Vipas39
gene id: 10116:Vipas39
uniprot id: A6JE90
uniprot id: Q5PQN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPE39 family.
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endosome
messages: Interacts with VPS33B (By similarity). Associates with the homotypic fusion and vacuole protein sorting (HOPS) complex; impaired by VPS33B. Interacts with RAB11A (By similarity).
messages: Late endosome
messages: Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B. May play a role in vesicular trafficking during spermatogenesis. May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity).
messages: Recycling endosome
messages: Vesicle

10116:Bbs7
gene id: 10116:Bbs7
uniprot id: Q66H90
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

10116:Adi1
gene id: 10116:Adi1
uniprot id: Q562C9
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.
messages: Cell membrane
messages: Cytoplasm
messages: Detected in prostate, liver, heart, brain, muscle, kidney and seminal vesicles.
messages: Monomer. Interacts with MMP14.
messages: Nucleus
messages: Up-regulated by androgens in the prostate, but not in the other tissues tested.

10116:Atp6v1b1
gene id: 10116:Atp6v1b1
uniprot id: A6IAP1
uniprot id: D3ZZS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

10116:RGD1306782
gene id: 10116:RGD1306782
uniprot id: D4AAT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB11 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane

10116:Txndc12
gene id: 10116:Txndc12
uniprot id: Q498E0
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen
messages: Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity.

10116:Celf2
gene id: 10116:Celf2
uniprot id: A6JLW4
uniprot id: Q792H5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Interacts with A1CF.
messages: Nucleus
messages: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediately upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats (By similarity). May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (By similarity).
messages: Strongly expressed in forebrain regions, including the cerebral cortex and hippocampus. Moderately expressed in hindbrain regions, including the cerebellum and spinal cord.

10116:Dclk1
gene id: 10116:Dclk1
uniprot id: A0A8L2QB01
uniprot id: A6JVF3
uniprot id: O08875
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
messages: Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (By similarity).

10116:Cspg5
gene id: 10116:Cspg5
uniprot id: Q9ERQ6
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Cell surface
messages: Different forms of various molecular weight have been observed. Such forms are possibly due to different levels of glycosylation, phosphorylation and/or protein cleavage (By similarity).
messages: Endoplasmic reticulum membrane
messages: Expressed in cerebral cortex and cerebellum. Expressed in retina (at protein level).
messages: Expression starts at 16 dpc in the cerebral cortex and increases to reach a maximum 20 days after birth. Then it decreases till adulthood to be expressed half of the peak level. In the retina, expression reaches a maximum at postnatal day 14 (P14). It starts weakly at 16 dpc in the retinal pigment epithelium (RPE). At P0 it is detected in nerve fiber layer (NFL), ganglion cell layer (GCL), inner plexiform layer (IPL) and RPE. At P7, it becomes intense in the NFL and IPL. At P14, expression becomes intense in the area of outer segments (OS) of the photoreceptor cells as well as in RPE, whereas in the inner layers it becomes gradually fainter. From P21 to P42, it decreases in inner retinal layers. OS and RPE still express, whereas expression in the NFL and IPL decreases (at protein level).
messages: Golgi apparatus membrane
messages: Interacts with ERBB3 and GOPC. Binds TNR and probably TNC (By similarity). Interacts with MDK; this interaction is independent of the presence of chondroitin sulfate chains and promotes elongation of oligodendroglial precursor-like cells (PubMed:16901907).
messages: May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.
messages: N-glycosylated.
messages: O-glycosylated; contains chondroitin sulfate glycans. Part-time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form. The relative amount of both forms depends on tissues and tissue maturation (By similarity).
messages: Phosphorylated; in intracellular and extracellular parts.
messages: Secreted
messages: Synaptic cell membrane
messages: Up-regulated in nucleus accumbens shell by cocaine administration.

10116:Nemp1
gene id: 10116:Nemp1
uniprot id: A6HQW7
uniprot id: M0R7R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

10116:Gnpnat1
gene id: 10116:Gnpnat1
uniprot id: A6KDZ8
uniprot id: F7EV78
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

10116:Shc1
gene id: 10116:Shc1
uniprot id: Q5M824
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with CPNE3; this interaction may mediate the binding of CPNE3 with ERBB2 (By similarity). Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR in vitro via the PID domain. Once activated, binds to GRB2. Interacts with tyrosine-phosphorylated CD3T and DDR2. Interacts with the N-terminal region of APS. Interacts with phosphorylated LRP1 and IRS4. Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with ALK, GAB2, GRB7 and KIT. Interacts with PTPN6/SHP (tyrosine phosphorylated). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2A, SRC, SHC1, GAP43 and CTTN. Interacts with EPHB1 and GRB2; activates the MAPK/ERK cascade to regulate cell migration. Interacts with PDGFRB (tyrosine-phosphorylated). Interacts with ERBB4. Interacts with TEK/TIE2 (tyrosine-phosphorylated). Interacts with PTK2/FAK1 (By similarity). Interacts with FLT4 (tyrosine-phosphorylated). Interacts with the Trk receptors NTRK1, NTRK2 and NTRK3; in a phosphotyrosine-dependent manner. Interacts with CEACAM1; this interaction is CEACAM1-phosphorylation-dependent and mediates interaction with EGFR or INSR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity) (PubMed:11694516). Interacts (via PID domain) with PEAK1 (when phosphorylated) (By similarity). Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1 (By similarity).
messages: Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to KIT signaling. Tyrosine phosphorylated in response to FLT3 signaling and by ligand-activated ALK. Tyrosine phosphorylated by TEK/TIE2 (By similarity). Tyrosine phosphorylated by ligand-activated PDGFRB (By similarity). May be tyrosine phosphorylated by activated PTK2/FAK1 (By similarity). Dephosphorylation by PTPN2 may regulate interaction with GRB2 (By similarity). Phosphorylated in response to FLT4 signaling. Tyrosine phosphorylated by activated PTK2B/PYK2.
messages: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity).
messages: focal adhesion

10116:Copb2
gene id: 10116:Copb2
uniprot id: O35142
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Probably interacts with PEX11A. Interacts with JAGN1 (By similarity). Interacts with SCYL1.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
messages: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner.
messages: cytosol

10116:Olr1111
gene id: 10116:Olr1111
uniprot id: D4A8Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Rims3
gene id: 10116:Rims3
uniprot id: Q9JIR3
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds PPFIA3. Does not bind RAB3.
messages: Expressed exclusively in brain with significant levels in cortex, cerebellum and olfactory bulb. Detected at lower level in hippocampus.
messages: Regulates synaptic membrane exocytosis.
messages: Synapse

10116:Galnt6
gene id: 10116:Galnt6
uniprot id: D4A864
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

10116:Epm2a
gene id: 10116:Epm2a
uniprot id: Q91XQ2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Homodimer. Interacts with itself. Interacts with PPP1R3B, PPP1R3C, PPP1R3D, HIRIP5, and EPM2AIP1. Binds glycogen and Lafora bodies. Interacts with NHLRC1/malin (via the NHL repeats). Forms a complex with NHLRC1/malin and HSP70. Interacts with PPP1R3D; in the presence of NHLC1/malin the interaction leads to ubiquitination and autophagic degradation of PPP1R3D. Interacts (via the phosphatase domain) with MAPT/Tau; the interaction dephosphorylates MAPT. Interacts with PRDM8.
messages: Phosphorylation on Ser-25 by AMPK affects the phosphatase activity of the enzyme and its ability to homodimerize and interact with NHLRC1, PPP1R3C or PRKAA2.
messages: Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro). Has also been shown to dephosphorylate MAPT. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates. Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.
messages: Polyubiquitinated by NHLRC1/malin.
messages: The CBM20 domain mediates binding to cytoplasmic glycogen and to Lafora polyglucosan bodies.
messages: Widely expressed.

10116:Rem1
gene id: 10116:Rem1
uniprot id: A6KHP5
uniprot id: F7EX35
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

10116:Tnf
gene id: 10116:Tnf
uniprot id: A6KTW8
uniprot id: P16599
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity).
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.
messages: Homotrimer. Interacts with SPPL2B (By similarity).
messages: Homotrimer. Interacts with SPPL2B.
messages: Membrane
messages: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
messages: Secreted
messages: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity).
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.
messages: The soluble form is demyristoylated by SIRT6, promoting its secretion.

10116:Acyp1
gene id: 10116:Acyp1
uniprot id: A0A0G2K899
uniprot id: A6JE20
uniprot id: D4A6X4
names: Similarity
messages: Belongs to the acylphosphatase family.

10116:Katnb1
gene id: 10116:Katnb1
uniprot id: A0A0G2JX20
uniprot id: Q4VFZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

10116:Dbil5
gene id: 10116:Dbil5
uniprot id: P56702
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ACBP family.
messages: Cytoplasm
messages: May be involved in the energy metabolism of the mature sperm.
messages: Specifically expressed in late haploid male germ cells.
messages: Testis.

10116:Entpd3
gene id: 10116:Entpd3
uniprot id: A6I414
uniprot id: A6I415
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

10116:Tas2r136
gene id: 10116:Tas2r136
uniprot id: A6IMB4
uniprot id: Q675B7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Putative taste receptor which may play a role in the perception of bitterness.
messages: Several bitter taste receptors are expressed in a single taste receptor cell.

10116:Ralb
gene id: 10116:Ralb
uniprot id: P36860
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Interacts with EXOC2/Sec5 and EXOC8/Exo84. Interacts (via effector domain) with RALBP1.
messages: Midbody
messages: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (PubMed:17202486). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (PubMed:16382162). Required for suppression of apoptosis (By similarity). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (By similarity). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (By similarity).
messages: Prenylation is essential for membrane localization.
messages: The farnesylated form confers resistance to the proapoptotic and anti-anchorage-dependent growth effects of some geranylgeranyltransferase I inhibitors.

10116:Recql5
gene id: 10116:Recql5
uniprot id: D4ACP5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. RecQ subfamily.
messages: DNA helicase that plays an important role in DNA replication, transcription and repair. Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability. Associates also with POLR1A and enforces the stability of ribosomal DNA arrays. Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress. Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination.
messages: Monomer. Interacts with TOP2A, TOP3A and TOP3B. Interacts with RNA polymerase II subunit POLR2A. Identified in a complex with the RNA polymerase II core bound to DNA. Interacts with RAD51. Interacts with WRN; this interaction stimulates WRN helicase activity on DNA fork duplexes. Interacts with MUS1; this interaction promotes MUS81-dependent mitotic DNA synthesis.
messages: Phosphorylated by CDK1 at Ser-728; this phosphorylation is required for RECQL5-mediated disruption of RAD51 filaments on stalled replication forks.
messages: nucleoplasm

10116:Disc1
gene id: 10116:Disc1
uniprot id: Q810H6
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed at high levels at 20.5 dpc. Expressed at lower levels at P2 and P6 and in adults (at protein level).
messages: Expressed in brain, heart, kidney, liver and thymus. Within the brain expression is high in the cerebral cortex, hippocampus and olfactory bulb and is also seen at lower levels in the cerebellum (at protein level).
messages: Interacts with NDEL1 (PubMed:17035248). Interacts with CCDC88A (via C-terminus); the interaction is direct. Interacts with GSK3B (By similarity). Interacts with tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, NDEL1, PAFAH1B1, RANBP9, SPTBN4, SYNE1 and TRAF3IP1. Interaction with microtubules may be mediated in part by TRAF3IP1. Interacts (via C-terminal) with PCNT. Interacts with CHCHD6 (By similarity). Interacts with CCDC141 (By similarity). Interacts with FBXW7, the substrate-recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex; the interaction targets DISC1 for proteasomal degradation (By similarity). Interacts with ZNF365 (PubMed:17389905). Interacts with ATF4; inhibiting ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (By similarity). Interacts with PDE4B (By similarity).
messages: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:17035248). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation (By similarity).
messages: Mitochondrion
messages: Postsynaptic density
messages: Ubiquitinated. Ubiquitination with 'Lys-48'-linked polyubiquitin chains leads to its proteasomal degradation.
messages: Up-regulated during neurite outgrowth upon differentiation with NGF.
messages: centrosome
messages: cytoskeleton

10116:Bag5
gene id: 10116:Bag5
uniprot id: Q5QJC9
names: Function
names: Subunit
names: Tissue Specificity
messages: Binds to the ATPase domain of HSP/HSP70 chaperones. Binds PRKN (By similarity). Interacts with HSPA8 and JPH2 (By similarity).
messages: Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding (By similarity). Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding (By similarity). Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (PubMed:15603737).
messages: Detected in brain, lung, stomach, liver, kidney and testis.

10116:Slc14a1
gene id: 10116:Slc14a1
uniprot id: A0A8I5ZWN6
uniprot id: A0A8J8XP37
uniprot id: A6KMX6
uniprot id: M0R8C6
uniprot id: P97689
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Expressed in brain, spleen, kidney, testis and lung, with highest levels in brain.
messages: Homotrimer; each subunit contains a pore through which urea permeates (By similarity). Identified in a complex with STOM (By similarity).
messages: Mediates the transport of urea driven by a concentration gradient across the cell membrane (PubMed:8982255). Mediates the transport of urea across the cell membranes of erythrocytes and the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity). Facilitates water transport in erythrocytes (By similarity).
messages: Membrane

10116:Ffar2
gene id: 10116:Ffar2
uniprot id: A6JA27
uniprot id: Q76EI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Detected in whole wall and separated mucosa in the distal ileum and colon. Expressed by enteroendocrine cells expressing peptide YY (PYY) (at protein level).
messages: G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes.
messages: Interacts with FCN1 (via Fibrinogen C-terminal domain).
messages: Membrane

10116:Or2t43
gene id: 10116:Or2t43
uniprot id: A0A8I6ADE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:RGD1311946
gene id: 10116:RGD1311946
uniprot id: Q4V7A5
names: Subcellular Location Annotation
messages: Cell membrane
messages: trans-Golgi network membrane

10116:Asap1
gene id: 10116:Asap1
uniprot id: Q1AAU6
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2).
messages: Cytoplasm
messages: Golgi apparatus
messages: Homodimer. Interacts with SRC and CRK. Interacts with RAB11FIP3. Interacts with PTK2B/PYK2. Interacts with CTTN. Interacts (via SH3 domain) with APC (By similarity). Interacts with REPS2; the interaction is direct (By similarity). Forms a complex containing RAB11A, ASAP1, RAB3IP, RAP11FIP3 and ARF4; the complex promotes preciliary trafficking; the complex binds to RHO in photoreceptor cells and promotes RHO ciliary transport (By similarity).
messages: Membrane
messages: Phosphorylated on tyrosine residues by SRC.
messages: Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (By similarity).
messages: The PH domain most probably contributes to the phosphoinositide-dependent regulation of ADP ribosylation factors.
messages: trans-Golgi network

10116:Or5ap2
gene id: 10116:Or5ap2
uniprot id: A0A0G2JUZ9
uniprot id: A6HMV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Vps25
gene id: 10116:Vps25
uniprot id: P0C0A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS25 family.
messages: Component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45 (By similarity). Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS36 and 2 copies of VPS25. Interacts with CFTR; the interaction requires misfolded CFTR. Interacts (via C-terminal half) with the ESCRT-III subunit CHMP6 (via N-terminal half) (By similarity).
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL.
messages: Cytoplasm
messages: Endosome membrane
messages: Nucleus

10116:Faim
gene id: 10116:Faim
uniprot id: Q8R5H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAIM1 family.
messages: Cytoplasm
messages: Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.

10116:Edil3
gene id: 10116:Edil3
uniprot id: A0A8I6B273
uniprot id: A6I4M7
uniprot id: F1M6P8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Tspan32
gene id: 10116:Tspan32
uniprot id: A6HY89
uniprot id: F7F785
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

10116:Cd302
gene id: 10116:Cd302
uniprot id: Q5FVR3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.
messages: cell cortex
messages: filopodium
messages: microvillus

10116:Hmx2
gene id: 10116:Hmx2
uniprot id: A6HWX2
uniprot id: D4A578
names: Subcellular Location Annotation
messages: Nucleus

10116:Cndp2
gene id: 10116:Cndp2
uniprot id: A6K5L5
uniprot id: Q6Q0N1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides. Mediates threonyl dipeptide catabolism in a tissue-specific way (By similarity). Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism. Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis. Plays a role in the regulation of cell cycle arrest and apoptosis (By similarity).
messages: Cytoplasm
messages: Detected in neuronal cells in the dorsal part of the tuberomammilary nucleus of the posterior hypothalamus (at protein level). Expressed in the iris, ciliary body, trabecular meshwork, Schlemm's canal, sclera, retina, brain, kidney and lung.
messages: Homodimer.

10116:Cyp26a1
gene id: 10116:Cyp26a1
uniprot id: Q8VIL0
names: Similarity
messages: Belongs to the cytochrome P450 family.

10116:Cacna1b
gene id: 10116:Cacna1b
uniprot id: E1AW38
uniprot id: O89089
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

10116:Man2c1
gene id: 10116:Man2c1
uniprot id: P21139
uniprot id: Q5M9I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins (PubMed:2211613). Involved in the degradation of free oligosaccharides in the cytoplasm (By similarity).
messages: Cytoplasm
messages: Widely expressed. Highest expression in testis, adrenal gland, and kidney.

10116:Ccdc172
gene id: 10116:Ccdc172
uniprot id: Q6AXT4
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CCDC172 family.
messages: Cytoplasm
messages: Detected in spermatozoa (at protein level). Predominantly expressed in testis and in spermatozoa from the caput and corpus epididymis.
messages: Increased after 3 weeks of postnatal development.
messages: May interact with TEKT2.
messages: cilium

10116:Tcp11l1
gene id: 10116:Tcp11l1
uniprot id: A0A0G2K6F1
uniprot id: A6HNU7
names: Similarity
messages: Belongs to the TCP11 family.

10116:Uck1
gene id: 10116:Uck1
uniprot id: B5DF24
names: Similarity
messages: Belongs to the uridine kinase family.

10116:Ndufs6
gene id: 10116:Ndufs6
uniprot id: P52504
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS6 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane

10116:Or13n4
gene id: 10116:Or13n4
uniprot id: A0A8I6ACQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Cox8b
gene id: 10116:Cox8b
uniprot id: A6HXL6
uniprot id: P16221
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Increased levels in liver during prenatal development.
messages: Membrane
messages: Mitochondrion inner membrane

10116:Tex44
gene id: 10116:Tex44
uniprot id: Q5U2Y8
names: Subcellular Location Annotation
messages: Cytoplasm

10116:Trim26
gene id: 10116:Trim26
uniprot id: P62603
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinates upon viral infection. In turn, autoubiquitinated TRIM26 recruits NEMO and bridges TBK1-NEMO interaction.
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Plays also a central role in determining the response to different forms of oxidative stress by controlling levels of DNA glycosylases NEIL1, NEIL3 and NTH1 that are involved in repair of damaged DNA. Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. Positively regulates LPS-mediated inflammatory innate immune response by catalyzing the 'Lys-11'-linked polyubiquitination of TAB1 to enhance its activation and subsequent NF-kappa-B and MAPK signaling. In a manner independent of its catalytic activity, inhibits WWP2, a SOX2-directed E3 ubiquitin ligase, and thus protects SOX2 from polyubiquitination and proteasomal degradation. Ubiquitinates the histone acetyltransferase protein complex component PHF20 and thereby triggers its degradation in the nucleus after its recruitment by the histone demethylase KDM6B, serving as a scaffold protein. Upon induction by TGF-beta, ubiquitinates the TFIID component TAF7 for proteasomal degradation (By similarity). Induces ferroptosis by ubiquitinating SLC7A11, a critical protein for lipid reactive oxygen species (ROS) scavenging (By similarity).
messages: Interacts with TBK1; this interaction bridges together TBK1 and NEMO in order to activate TBK1. Interacts with INCA1.
messages: Nucleus

10116:Timeless
gene id: 10116:Timeless
uniprot id: Q9Z2Y1
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the timeless family.
messages: Chromosome
messages: Expressed in all tissues examined including brain, eye, lung, heart, liver, kidney, pancreas, placenta and testis. Highest levels of expression in eye, lung, liver, placenta and kidney. Expressed throughout the suprachiasmatic nucleus (SCN).
messages: In both brain and pancreas, no circadian oscillation was detected.
messages: Monomer (By similarity). Homodimer or homomultimer (By similarity). Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSKN1D and/or CSNK1E, TIMELESS, and the PER proteins (By similarity). Interacts directly with PER2; the interaction with PER2 is via its second PAS domain (PubMed:11112428). Interacts directly with PER1 and PER3 (By similarity). Interacts with CRY2, CHEK1, ATR and ATRIP (By similarity). Interacts with CRY1 (By similarity). Interacts with CLSPN; the interaction is required for leading-strand replication. Interacts (via N-terminus) with TIPIN (By similarity). The TIMELESS-TIPIN heterodimer binds preferably to guanine-rich quadruplex-forming (G4) DNA structures (By similarity). Associates with the MCM2-7 complex. Interacts with DNA polymerases alpha, delta and epsilon. Interacts with DDX11; this interaction increases recruitment of both proteins onto chromatin in response to replication stress induction by hydroxyurea. Interacts with PARP1; interaction is direct and independent of poly-ADP-ribose (By similarity).
messages: Nucleus
messages: Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (By similarity). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (By similarity). TIMELESS promotes TIPIN nuclear localization (By similarity). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX1 (By similarity). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (By similarity). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (By similarity). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (By similarity). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (By similarity). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (By similarity). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (PubMed:10963667).
messages: Residues 1178-1195 comprise a putative nuclear localization signal; nuclear localization is required for the regulation of period length of the circadian clock.
messages: The C-terminal domain, comprising the DNA-binding domain and the PARP1-binding region, is required for the replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures.
messages: The DNA-binding domain (residues 813-951) binds to both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA), and has high affinity for DNA sequences rich in guanine that form G-quadruplex (G4) structures.

10116:Tm9sf3
gene id: 10116:Tm9sf3
uniprot id: A0A8I6A822
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

10116:Or4k1
gene id: 10116:Or4k1
uniprot id: A0A8I5ZSK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tmprss11c
gene id: 10116:Tmprss11c
uniprot id: F7FFT3
uniprot id: Q6IE15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

10116:Ypel3
gene id: 10116:Ypel3
uniprot id: A6I9D3
names: Similarity
messages: Belongs to the yippee family.

10116:Kcnb1
gene id: 10116:Kcnb1
uniprot id: A0A0H2UI34
uniprot id: P15387
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated. Acetylation occurs in pancreatic beta cells in response to stimulation by incretin hormones in a histone acetyltransferase (HAT)/histone deacetylase (HDAC)-dependent signaling pathway, promoting beta cell survival (PubMed:21818121).
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
messages: Cell membrane
messages: Down-regulated by angiotensin II in a NFATC3-dependent manner (PubMed:15322114).
messages: Expressed in brain (PubMed:1740690, PubMed:1961744, PubMed:8508921, PubMed:7623158, PubMed:12954870). Expressed in the hippocampus, cerebral cortex, cerebellum, thalamus, hypothalamus, olfactory bulb, corpus striatum and medial hebenula (PubMed:8463836, PubMed:10414301, PubMed:16319318). Expressed in pancreatic islets (PubMed:12403834). Expressed in heart and skeletal muscle (PubMed:1740690, PubMed:19219384, PubMed:10414301). Levels remain constant throughout postnatal development (PubMed:17192433). Expressed in neocortical pyramidal neurons and inhibitory interneurons (PubMed:1961744, PubMed:9522360, PubMed:10618149, PubMed:12832499, PubMed:17192433, PubMed:17379638, PubMed:19014551, PubMed:20202934, PubMed:24477962). Expressed in the superior cervical ganglion (SCG) neurons (PubMed:12451110). Expressed in globus pallidus neurons (PubMed:10414968). Expressed in pancreatic beta cells (PubMed:11463864, PubMed:22411134). Expressed in cardiomyocytes (PubMed:17965280). Expressed in arterial smooth muscle, alveolar epithelium and parenchyma (at protein level) (PubMed:9362476, PubMed:9616203, PubMed:15322114). Expressed in brain, heart, lung, liver, colon, kidney and adrenal gland (PubMed:8508921, PubMed:9362476, PubMed:19074135). Expressed in pyramidal cells of the cerebral cortex, in Purkinje and granule cells of the cerebellum (PubMed:8463836). Expressed in CA1-CA3 pyramidal cells, dentate granule cells and interneurons of the hippocampus (PubMed:7623158, PubMed:10024359). Expressed in pulmonary artery (PA) smooth muscle cells (PubMed:9362476).
messages: Expressed in embryonic brain at 14 dpc, and thereafter (at protein level) (PubMed:8508921). Expressed in embryonic brain at 14 dpc, and thereafter (PubMed:8508921).
messages: Homotetramer or heterotetramer with KCNB2 (PubMed:20202934). Heterotetramer with non-conducting channel-forming alpha subunits such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1 (PubMed:8670833, PubMed:8980147, PubMed:9362476, PubMed:9079713, PubMed:9305895, PubMed:9696692). Channel activity is regulated by association with ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3 (PubMed:12954870, PubMed:19219384). Interacts with KCNV2 (By similarity). Self-associates (via N-terminus and C-terminus); self-association is required to regulate trafficking, gating and C-terminal phosphorylation-dependent modulation of the channel (PubMed:12560340, PubMed:18463252, PubMed:19690160). Interacts (via C-terminus) with STX1A (via C-terminus); this decreases the rate of channel activation and increases the rate of channel inactivation in pancreatic beta cells, induces also neuronal apoptosis in response to oxidative injury as well as pore-independent enhancement of exocytosis in neuroendocrine cells, chromaffin cells, pancreatic beta cells and from the soma of dorsal root ganglia (DRG) neurons (PubMed:12621036, PubMed:12807875, PubMed:17301173, PubMed:18167541, PubMed:19077057, PubMed:20484665, PubMed:22411134, PubMed:24928958). Interacts (via N-terminus) with SNAP25; this decreases the rate of channel inactivation in pancreatic beta cells and also increases interaction during neuronal apoptosis in a N-methyl-D-aspartate receptor (NMDAR)-dependent manner (PubMed:12403834, PubMed:12807875, PubMed:19077057). Interacts (via N-terminus and C-terminus) with VAMP2 (via N-terminus); stimulates channel inactivation rate (PubMed:18542995, PubMed:19690160, PubMed:19077057). Interacts with CREB1; this promotes channel acetylation in response to stimulation by incretin hormones (PubMed:21818121). Interacts (via N-terminus and C-terminus) with MYL12B (PubMed:24569993). Interacts (via N-terminus) with PIAS3; this increases the number of functional channels…
messages: Inhibited by 42 nM hanatoxin 1 (HaTx1), a spider venom toxin of the tarantula G. spatulata (PubMed:7576642). Inhibited by 100 nM stromatoxin 1 (ScTx1), a spider venom toxin of the tarantula S. calceata (PubMed:12065754). Modestly sensitive to millimolar levels of tetraethylammonium (TEA) and 4-aminopyridine (4-AP) (PubMed:2770868, PubMed:1875913, PubMed:8083226, PubMed:9362476). Completely insensitive to toxins such as dendrotoxin (DTX) and charybdotoxin (CTX) (PubMed:9362476).
messages: Lateral cell membrane
messages: Membrane
messages: Not glycosylated (PubMed:8083226).
messages: Perikaryon
messages: Phosphorylated (PubMed:8083226, PubMed:15195093, PubMed:16319318, PubMed:16407566, PubMed:18463252). Differential C-terminal phosphorylation on a subset of serines allows graded activity-dependent regulation of channel gating in hippocampal neurons (PubMed:9351973, PubMed:17192433, PubMed:16917065). Ser-607 and Tyr-128 are significant sites of voltage-gated regulation through phosphorylation/dephosphorylation activities (PubMed:12615930, PubMed:17192433). Tyr-128 can be phosphorylated by Src and dephosphorylated by cytoplasmic form of the phosphatase PTPRE isoform 2 (PubMed:12615930). CDK5-induced Ser-607 phosphorylation increases in response to acute blockade of neuronal activity (PubMed:21712386). Phosphorylated on Tyr-128 by Src and on Ser-804 by MAPK14/P38MAPK; phosphorylations are necessary and sufficient for an increase in plasma membrane insertion, apoptotic potassium current surge and completion of the neuronal cell death program (PubMed:17360683, PubMed:19622611). Phosphorylated on Ser-520, Ser-607, Ser-655 and Ser-804 by CDK5; phosphorylation is necessary for KCNB1 channel clustering formation (PubMed:21712386). The Ser-607 phosphorylation state differs between KCNB1-containing clusters on the proximal and distal portions of the axon initial segment (AIS) (PubMed:24477962). Highly phosphorylated on serine residues in the C-terminal cytoplasmic tail in resting neurons (PubMed:9351973, PubMed:16917065). Phosphorylated in pancreatic beta cells in response to incretin hormones stimulation in a PKA- and RPS6KA5/MSK1-dependent signaling pathway, promoting beta cell survival (PubMed:21818121). Phosphorylation on Ser-567 is reduced during postnatal development with low levels at P2 and P5; levels then increase to reach adult levels by P14 (PubMed:17192433). Phosphorylation on Ser-457, Ser-541, Ser-567, Ser-607, Ser-655 and Ser-719 as well as the N-terminal Ser-15 are sensitive to calcineurin-mediated dephosphorylation contributing to the modulation of the voltage-…
messages: Postsynaptic cell membrane
messages: Sumoylated on Lys-474, preferentially with SUMO1; sumoylation induces a positive shift in the voltage-dependence of activation and inhibits channel activity (PubMed:21518833). Sumoylation increases the frequency of repetitive action potential firing at the cell surface of hippocampal neurons and decreases its frequency in pancreatic beta cells (PubMed:21518833). Desumoylated by SENP1 (PubMed:21518833).
messages: Synapse
messages: Synaptic cell membrane
messages: The FFAT motif is involved in the interaction with VAPA and VAPB and its phosphorylation regulates these interactions.
messages: The N-terminal and C-terminal cytoplasmic regions mediate homooligomerization; self-association is required to regulate trafficking, gating and C-terminal phosphorylation-dependent modulation of the channel (PubMed:12560340, PubMed:18463252, PubMed:19690160). The N-terminal cytoplasmic region is important for interaction with other channel-forming alpha subunits and with ancillary beta subunits (PubMed:12954870, PubMed:19219384). The C-terminus is necessary and sufficient for the restricted localization to, and clustering within, both in soma and proximal portions of dendrite of neurons and in lateral membrane of non-neuronal polarized cells (PubMed:8978827, PubMed:10719893). The C-terminus is both necessary and sufficient as a mediator of cholinergic and calcium-stimulated modulation of channel cell membrane clustering localization and activity in hippocampal neurons (PubMed:16407566).
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
messages: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:10024359, PubMed:10618149, PubMed:12451110, PubMed:17379638, PubMed:19276663, PubMed:23878373). Also plays a role in the regulation of exocytosis independently of its electrical function (PubMed:20484665). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:2770868, PubMed:2206531, PubMed:1875913, PubMed:8083226, PubMed:8978827, PubMed:9351973, PubMed:9565597, PubMed:12560340). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:20202934). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed:8670833, PubMed:8980147, PubMed:9362476, PubMed:9079713, PubMed:9305895, PubMed:9696692). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary …
messages: axon
messages: dendrite
messages: sarcolemma
messages: synaptosome

10116:Ube2h
gene id: 10116:Ube2h
uniprot id: M0R4P9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

10116:Marcksl1
gene id: 10116:Marcksl1
uniprot id: A6J9R3
uniprot id: Q9EPH2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MARCKS family.
messages: Binds to filamentous actin (F-actin), but not to monomeric G-actin, independently of its phosphorylation status. Interacts with calmodulin.
messages: Cell membrane
messages: Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems.
messages: Phosphorylated. Phosphorylation at Ser-120 and Thr-183 is non-redundantly catalyzed by MAPK8 in vivo. Phosphorylation at Thr-148 is preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the absence of MAPK8. May be phosphorylated by protein kinase C, which disrupts the interaction with calmodulin.
messages: cytoskeleton

10116:Pde5a
gene id: 10116:Pde5a
uniprot id: A0A8I6GLL2
uniprot id: A6HVG9
uniprot id: O54735
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 1 Mg(2+) ions per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium. Binds magnesium less tightly than zinc.
messages: Binds 1 Zn(2+) ion per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium. Tightly binds zinc.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain which contains two homologous allosteric cGMP-binding regions, A and B.
messages: Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Phosphorylation by PRKG1 leads to its activation.
messages: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.

10116:Irf7
gene id: 10116:Irf7
uniprot id: Q3SWU2
names: Subcellular Location Annotation
messages: Nucleus

10116:Tcl1a
gene id: 10116:Tcl1a
uniprot id: A6JES4
uniprot id: D3ZWG3
names: Similarity
messages: Belongs to the TCL1 family.

10116:LOC100910554
gene id: 10116:LOC100910554
uniprot id: A0A8I6ARS7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

10116:Tprn
gene id: 10116:Tprn
uniprot id: Q5XHX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the taperin family.
messages: stereocilium

10116:Pop4
gene id: 10116:Pop4
uniprot id: A6JAE6
uniprot id: Q5M882
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5.
messages: Component of nuclear RNase P and RNase MRP.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

10116:LOC102552128
gene id: 10116:LOC102552128
uniprot id: A0A8I6ABX7
names: Similarity
messages: Belongs to the LCE family.

10116:Ttc9c
gene id: 10116:Ttc9c
uniprot id: A6HZU8
uniprot id: Q6P5P3
names: Similarity
messages: Belongs to the TTC9 family.

10116:Med1
gene id: 10116:Med1
uniprot id: A6HIQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

10116:Arhgdig
gene id: 10116:Arhgdig
uniprot id: A0A8I5ZRJ5
uniprot id: A6HD94
names: Similarity
messages: Belongs to the Rho GDI family.

10116:Clock
gene id: 10116:Clock
uniprot id: Q9WVS9
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins (By similarity). Forms a heterodimer with BMAL1 (By similarity). The CLOCK-BMAL1 heterodimer is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and for phosphorylation of both CLOCK and BMAL1 (By similarity). Interacts with NR3C1 in a ligand-dependent fashion (By similarity). Interacts with ESR1 and estrogen stimulates this interaction (By similarity). Interacts with the complex p35/CDK5 (By similarity). Interacts with RELA/p65 (By similarity). Interacts with KAT2B, CREBBP and EP300 (By similarity). Interacts with ID1 and ID3 (By similarity). Interacts with ID2 (By similarity). Interacts with MTA1 (By similarity). Interacts with OGA (By similarity). Interacts with SIRT1 (By similarity). Interacts with CIPC (By similarity). Interacts with EZH2 (By similarity). Interacts with EIF4E, PIWIL1 and DDX4 (By similarity). Interacts with PER1, PER2, CRY1 and CRY2 and this interaction requires a translocation to the nucleus (By similarity). Interaction of the CLOCK-BMAL1 heterodimer with PER or CRY inhibits transcription activation (By similarity). Interaction of the CLOCK-BMAL1 with CRY1 is independent of DNA but with PER2 is off DNA (By similarity). The CLOCK-BMAL1 heterodimer interacts with GSK3B (By similarity). Interacts with KDM5A (By similarity). Interacts with KMT2A; in a circadian manner (By similarity). Interacts with MYBBP1A (By similarity). Interacts with THRAP3 (By similarity). Interacts with MED1; this interaction requires the presence of THRAP3 (By similarity). Interacts with NCOA2 (By similarity). The CLOCK-BMAL1 heterodimer interacts with PASD1. Interacts with ASS1 and IMPDH2; in a circadian manner. Interacts with NDUFA9 (By similarity). Interacts with PIWIL2 (via PIWI domain) (By similarity). Interacts with HNF4A (By similarity).
messages: Cytoplasm
messages: Expressed in the suprachiasmatic nucleus (SCN), and in the piriform cortex (PC).
messages: Nucleus
messages: O-glycosylated; contains O-GlcNAc. O-glycosylation by OGT prevents protein degradation by inhibiting ubiquitination. It also stabilizes the CLOCK-BMAL1 heterodimer thereby increasing CLOCK-BMAL1-mediated transcriptional activation of PER1/2/3 and CRY1/2.
messages: Phosphorylation is dependent on the CLOCK-BMAL1 heterodimer formation. Phosphorylation enhances the transcriptional activity, alters the subcellular localization and decreases the stability of the heterodimer by promoting its degradation. Phosphorylation shows circadian variations in the liver. May be phosphorylated by CSNK1D and CKSN1E.
messages: Sumoylation enhances its transcriptional activity and interaction with ESR1, resulting in up-regulation of ESR1 activity. Estrogen stimulates sumoylation. Desumoylation by SENP1 negatively regulates its transcriptional activity.
messages: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a …
messages: Ubiquitinated, leading to its proteasomal degradation.
messages: Undergoes lysosome-mediated degradation in a time-dependent manner in the liver.
messages: Without light exposure, high levels at ZT6 and low levels at ZT18 and ZT22. Light exposure increases levels in the SCN in phase dependent manner. Levels increased significantly during the subjective night (ZT10-20). In the piriform cortex, levels increased by light at ZT14.
messages: cytosol

10116:Emc8
gene id: 10116:Emc8
uniprot id: A6IZM7
uniprot id: Q5FVL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC8/EMC9 family.
messages: Component of the ER membrane protein complex (EMC). EMC8 and EMC9 are mutually exclusive subunits of the EMC complex.
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.

10116:Prr15
gene id: 10116:Prr15
uniprot id: A0A8I5ZQ45
uniprot id: A6K0U8
names: Similarity
messages: Belongs to the PRR15 family.

10116:Aqp11
gene id: 10116:Aqp11
uniprot id: Q8CHM1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Cell membrane
messages: Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain. In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (By similarity). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER. Plays a role in the proximal tubule function by regulating its endosomal acidification. May play a role in postnatal kidney development (By similarity).
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Expressed in retina specifically at retinal Mueller glial cells (PubMed:27107718). Expressed in adult testis, in the elongated spermatids (ES) and in residual bodies inside Sertoli cells (PubMed:19812234).
messages: Homodimer; disulfide-linked. Homotrimer (By similarity). Can also form homomultimer (By similarity).
messages: Not glycosylated.
messages: The NPC motif is essential for oligomerization and water permeability function.
messages: perinuclear region

10116:Amn
gene id: 10116:Amn
uniprot id: A6KBQ1
uniprot id: D3ZFK9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Kit
gene id: 10116:Kit
uniprot id: B7SCI8
uniprot id: Q63116
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

10116:Amdhd2
gene id: 10116:Amdhd2
uniprot id: A6HCQ3
uniprot id: Q5BJY6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.
messages: Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.

10116:Or4a78
gene id: 10116:Or4a78
uniprot id: A0A8I5ZQH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Sparc
gene id: 10116:Sparc
uniprot id: A6HEL9
uniprot id: P16975
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
messages: Belongs to the SPARC family.
messages: Membrane
messages: basement membrane

10116:Vamp1
gene id: 10116:Vamp1
uniprot id: A6ILT1
uniprot id: Q63666
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which hydrolyzes the 61-Lys-|-Leu-62 bond and inhibits neurotransmitter release (PubMed:8175689). This is a poor substrate for BoNT/D, high concentrations are required to cleave it in vitro (PubMed:8175689).
messages: (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 60-Gln-|-Lys-61 bond and inhibits neurotransmitter release (PubMed:8505288).
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Expressed in brain and spleen (at protein level). Isoform 1 expressed at very high level in brain. Even higher level found in spinal cord. Isoform 3 expressed in kidney, spleen and liver. Isoforms 2 and 3 expressed in osteoblasts of trabecular bone. Also expressed in heart.
messages: Interacts with VAPA and VAPB.
messages: Involved in the targeting and/or fusion of transport vesicles to their target membrane.
messages: Is not targeted by C.botulinum neurotoxin type B (BoNT/B) or by C.tetani toxin (tetX) as their target sequence is not conserved in this protein (PubMed:1331807, PubMed:8175689).
messages: Membrane
messages: Mitochondrion outer membrane
messages: synaptic vesicle membrane
messages: synaptosome

10116:Tbk1
gene id: 10116:Tbk1
uniprot id: A6IH00
uniprot id: D4A7D3
names: Subcellular Location Annotation
messages: Cytoplasm

10116:Csta3
gene id: 10116:Csta3
uniprot id: A0A8I6AKE1
names: Similarity
messages: Belongs to the cystatin family.

10116:Barhl1
gene id: 10116:Barhl1
uniprot id: A6JTQ3
uniprot id: P63156
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAR homeobox family.
messages: Nucleus

10116:Sh3pxd2a
gene id: 10116:Sh3pxd2a
uniprot id: A0A8I6AP29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3PXD2 family.
messages: Cytoplasm

10116:Adcyap1
gene id: 10116:Adcyap1
uniprot id: A6KFB2
uniprot id: P13589
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucagon family.
messages: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (PubMed:18198219). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).
messages: Interacts with ADCYAP1R1 (via N-terminal extracellular domain).
messages: Secreted

10116:Htr5a
gene id: 10116:Htr5a
uniprot id: A6KJK9
uniprot id: P35364
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Central nervous system.
messages: Membrane
messages: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

10116:Specc1l
gene id: 10116:Specc1l
uniprot id: A6JKL5
uniprot id: Q2KN99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytospin-A family.
messages: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity).
messages: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
messages: May interact with both microtubules and actin cytoskeleton.
messages: cytoskeleton
messages: gap junction
messages: spindle

10116:RGD1564617
gene id: 10116:RGD1564617
uniprot id: D3ZDE0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

10116:Usp46
gene id: 10116:Usp46
uniprot id: F1M625
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase C19 family. USP12/USP46 subfamily.
messages: Detected in lung and spleen, and at lower levels in brain, kidney, testis and liver.
messages: Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2 (By similarity).
messages: Interacts with WDR48. Interacts with WDR20.

10116:Slit3
gene id: 10116:Slit3
uniprot id: O88280
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Detected at 20 dpc, and between P0 and P5 in olfactory mitral cells. Detected between 18 dpc and 20 dpc, between P0 and P10, and in adult in anterior olfactor, hypothalamus ventromedial nuclei. Detected at 15 dpc in cortex marginal zone. Detected between 15 dpc and 20 dpc, between P0 and P10, and in adult in cortex entorhinal and periform region, hippocampal regions, basal telencephalon bed stria terminalis nuclei. Detected at 20 dpc, between P0 and P10, and in adult in cortex induseum griseum and tenia tecta, and basal telencephalon olfactory tubercle. Detected between P0 and P10, and in adult in ventral thalamus zona incerta. Detected between P5 and P10, and in adult in ventral thalamus reticular nuclei. Detected between P0 and P10, and in adult in dorsal thalamus regions.
messages: May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
messages: Secreted

10116:Higd1b
gene id: 10116:Higd1b
uniprot id: A6HJM9
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

10116:Or5p66b
gene id: 10116:Or5p66b
uniprot id: D3ZNU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Syngr2
gene id: 10116:Syngr2
uniprot id: O54980
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the synaptogyrin family.
messages: Cytoplasmic vesicle membrane
messages: May be tyrosine phosphorylated by Src.
messages: May play a role in regulated exocytosis (PubMed:10383386). In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles (PubMed:12928441, PubMed:15590695). May also play a role in GLUT4 storage and transport to the plasma membrane (PubMed:26071524).
messages: Ubiquitously expressed with lower expression in brain (at protein level).
messages: synaptic vesicle membrane

10116:Zbtb24
gene id: 10116:Zbtb24
uniprot id: Q3B725
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Interacts with MN1.
messages: May be involved in BMP2-induced transcription.
messages: Nucleus

10116:Olr1867
gene id: 10116:Olr1867
uniprot id: P34987
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Epithelium of the tongue; including the taste buds.
messages: Possible olfactory or taste receptor.

10116:Wbp2
gene id: 10116:Wbp2
uniprot id: Q8R478
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Required for YAP1 coactivation function on PGR activity. Synergizes with WBP2 in enhancing PGR activity (By similarity). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity).
messages: Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with NEDD4 (By similarity). Interacts with ESR1 and UBE3A (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated in repsonse to EGF as well as estrogen and progesterone hormones. Tyr-192 and Tyr-232 are phosphorylated by YES and SRC inducing nuclear translocation.
messages: The PPxY motif 1 mediates interaction with NEDD4 (By similarity). The PPxY motif 2 is required for the coactivation function (By similarity).

10116:Edn1
gene id: 10116:Edn1
uniprot id: A6J756
uniprot id: P22388
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:9508787).
messages: Secreted

10116:Fcmr
gene id: 10116:Fcmr
uniprot id: Q5M871
names: Domain
names: Function
names: Subcellular Location Annotation
messages: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation (By similarity).
messages: Membrane
messages: The Ig-like domain is required for the anti-apoptotic ability.

10116:Slc38a9
gene id: 10116:Slc38a9
uniprot id: Q3B8Q3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated component of the Ragulator complex (composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5). Associated component of the Rag GTPases heterodimers (composed of RRAGA, RRAGB, RRAGC and RRAGD); this interaction is independent of the Ragulator complex but depends on the nucleotide loading state of the Rag GTPase heterodimer. Interacts with TM4SF5. Interacts with NPC1; this interaction inhibits cholesterol-mediated mTORC1 activation via its sterol transport activity.
messages: Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily.
messages: Glycosylated.
messages: Late endosome membrane
messages: Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids. Acts as an arginine sensor. Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation. However, the transport mechanism is not well defined and the role of sodium is not clear. Can disassemble the lysosomal folliculin complex (LFC), and thereby triggers GAP activity of FLCN:FNIP2 toward RRAGC. Acts as an cholesterol sensor that conveys increases in lysosomal cholesterol, leading to lysosomal recruitment and activation of mTORC1 via the Rag GTPases. Guanine exchange factor (GEF) that, upon arginine binding, stimulates GDP release from RRAGA and therefore activates the Rag GTPase heterodimer and the mTORC1 pathway in response to nutrient sufficiency.
messages: Lysosome membrane
messages: The cytosolic N-terminus part of the protein mediates interaction with the Ragulator complex. The cytosolic N-terminus part of the protein destabilizes the LFC and thereby triggers GAP activity of FLCN:FNIP2 toward RRAGC. The cytosolic N-terminus part of the protein mediates interaction with the Rag GTPase heterodimer in a RRAGA GDP-loaded state dependent and upon arginine binding, leading to the GDP release and SLC38A9 dissociation from the activated Rag GTPase heterodimer (By similarity). The cytosolic N-terminus part of the protein exists at least in two distinct conformations; The first is when the N-terminus is bound snugly in the arginine binding site (in the absence of arginine, low luminal arginine state) and the second is where the N-terminus is released and the substrate-binding site is occupied by arginine (in the presence of arginine, high luminal arginine state) (By similarity).
messages: the CARC and CRAC motifs mediate binding to cholesterol.

10116:Taf1c
gene id: 10116:Taf1c
uniprot id: Q6P773
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with MYC and RRN3. Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and represses RNA polymerase I transcription (By similarity).
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3 (By similarity).
messages: Nucleus

10116:Gga2
gene id: 10116:Gga2
uniprot id: A6I8V4
uniprot id: G3V8F7
uniprot id: Q4G038
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

10116:Htr3a
gene id: 10116:Htr3a
uniprot id: A0A8L2Q4R5
uniprot id: A6J4A7
uniprot id: P35563
uniprot id: Q62999
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily.
messages: By nerve growth factor in PC12 cells.
messages: Cell membrane
messages: Expressed in central and peripheral neurons.
messages: Forms homopentameric as well as heteropentameric serotonin-activated cation-selective channel complexes with HTR3B or HTR3C or HTR3D or HTR3E. The homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Heteropentameric complexes display properties which resemble that of neuronal serotonin-activated channels in vivo (PubMed:10854267, PubMed:12151552). Interacts with RIC3 (By similarity).
messages: Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomers compared to that of HTR3A/HTR3B heteromers.

10116:Myl3
gene id: 10116:Myl3
uniprot id: P16409
names: Function
names: PTM
names: Subunit
names: Tissue Specificity
messages: Expressed only in ventricular and slow twitch skeletal muscle tissues.
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains.
messages: N-terminus is methylated by METTL11A/NTM1.
messages: Regulatory light chain of myosin. Does not bind calcium.

10116:Olr1278
gene id: 10116:Olr1278
uniprot id: O35184
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Or12e7
gene id: 10116:Or12e7
uniprot id: M0RBB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tmem39b
gene id: 10116:Tmem39b
uniprot id: A6ISL7
uniprot id: Q66H44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Endoplasmic reticulum membrane
messages: May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase.
messages: Membrane

10116:Slc4a5
gene id: 10116:Slc4a5
uniprot id: Q6RI88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3.
messages: Observed in hepatocytes and in the apical region of bile duct intrahepatic cholangiocytes of liver. Also observed in uroepithelium cells lining the outer pelvic wall of the kidney (at protein level). Highly expressed in colon, distal colon, liver, kidney and testis. Moderate expression in duodenum and stomach and weak expression in heart. In kidney, very weakly expressed in the inner medulla, but abundantly expressed in cortex and outer medulla in the medullary thick ascending and cortical thick ascending limbs of the loop of Henle.

10116:Or6b6
gene id: 10116:Or6b6
uniprot id: A6I7Q6
uniprot id: D3ZNV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Golt1b
gene id: 10116:Golt1b
uniprot id: B0BNB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

10116:Nck1
gene id: 10116:Nck1
uniprot id: A0A9K3Y859
uniprot id: B2RZ33
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

10116:Cacnb1
gene id: 10116:Cacnb1
uniprot id: A0A0G2K4U4
uniprot id: A0A8I6ASP4
uniprot id: P54283
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calcium channel beta subunit family.
messages: Cell membrane
messages: Detected in brain.
messages: Membrane
messages: Regulatory subunit of L-type calcium channels that consist of a pore-forming alpha subunit and auxiliary beta, gamma and delta subunits (PubMed:21127204). Interacts with CACNA1A, CACNA1B, CACNA1C and CACNA1S (By similarity). Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. Identified in a complex with CACNA1C (By similarity). Identified in a complex with the L-type calcium channel subunits CACNA1C, CACNA2D1, CACNB1 and one of the gamma subunits (CACNG4, CACNG6, CACNG7, or CACNG8) (PubMed:21127204). Part of a L-type calcium channel complex that contains CACNA1D, CACNA2D1 and CACNB1. Part of a L-type calcium channel complex that contains CACNA1B, CACNA2D1 and CACNB1 (By similarity). Interacts with JSRP1. Interacts with RYR1 (By similarity). Interacts with CBARP (PubMed:24751537).
messages: Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (Probable). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (By similarity).
messages: sarcolemma

10116:Tk2
gene id: 10116:Tk2
uniprot id: A6JXX0
uniprot id: D3ZGQ2
names: Similarity
messages: Belongs to the DCK/DGK family.

10116:Tcea3
gene id: 10116:Tcea3
uniprot id: Q5BK74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

10116:Hsd3b2
gene id: 10116:Hsd3b2
uniprot id: A6K3E0
uniprot id: Q62878
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
messages: Belongs to the 3-beta-HSD family.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: Skin, placenta, also detectable in ovary and adrenal gland.

10116:Chst11
gene id: 10116:Chst11
uniprot id: A0A8L2Q5L8
uniprot id: A6IFH2
uniprot id: P69478
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor (By similarity).
messages: Golgi apparatus membrane
messages: Membrane
messages: N-glycosylated; required for activity and stability.

10116:Tmem63a
gene id: 10116:Tmem63a
uniprot id: A0A0G2JVY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

10116:Tfcp2l1
gene id: 10116:Tfcp2l1
uniprot id: A6K7W1
uniprot id: D3ZHA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

10116:Tagln3
gene id: 10116:Tagln3
uniprot id: A6IQX9
uniprot id: P37805
names: Similarity
names: Tissue Specificity
messages: Abundant and ubiquitous expression in neurons.
messages: Belongs to the calponin family.

10116:Mycl
gene id: 10116:Mycl
uniprot id: A6IS13
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

10116:U2af2
gene id: 10116:U2af2
uniprot id: A6KNR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Necessary for the splicing of pre-mRNA.
messages: Nucleus

10116:Tril
gene id: 10116:Tril
uniprot id: Q496Z2
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4. Interacts with TLR4; this interaction is greatly enhanced following LPS stimulation (By similarity). Interacts with LPS (By similarity).
messages: Component of the TLR4 signaling complex. Mediates the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion and the inflammatory response (By similarity).
messages: Highly expressed in cortical astrocytes and in cerebellar granule neurons.
messages: Membrane
messages: N-glycolysaled.

10116:Grhpr
gene id: 10116:Grhpr
uniprot id: B0BN46
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

10116:Crebbp
gene id: 10116:Crebbp
uniprot id: F1M9G7
names: Subcellular Location Annotation
messages: Cytoplasm

10116:Kcnj2
gene id: 10116:Kcnj2
uniprot id: A6HKE4
uniprot id: Q64273
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking.
messages: Membrane
messages: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).
messages: Prominently expressed in the central nervous system. Also found in other excitable tissues such as heart and skeletal muscle.
messages: S-nitrosylation increases the open probability and inward rectifying currents.

10116:Or5k8
gene id: 10116:Or5k8
uniprot id: D4AAE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Or5d40
gene id: 10116:Or5d40
uniprot id: A0A8I6A1W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Mgst2
gene id: 10116:Mgst2
uniprot id: A0A8I5ZLK2
uniprot id: A6JV75
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:Ndufb6
gene id: 10116:Ndufb6
uniprot id: A6IIR1
uniprot id: D3ZZ21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

10116:Or8h6
gene id: 10116:Or8h6
uniprot id: A0A8I6A389
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Or2g25
gene id: 10116:Or2g25
uniprot id: A0A8I6A7T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Xpnpep3
gene id: 10116:Xpnpep3
uniprot id: B5DEQ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M24B family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position. Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling.
messages: Cytoplasm
messages: Expressed in the kidney, specifically in intercalated cells, but not in principal cells, of the distal convoluted tubule and cortical collecting duct (at protein level).
messages: Homodimer. Interacts with TNFRSF1B/TNFR2 (activated) and TRAF2.
messages: Mitochondrion

10116:Rpl19
gene id: 10116:Rpl19
uniprot id: A6HIP8
uniprot id: P84100
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Citrullinated by PADI4.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

10116:Polr1f
gene id: 10116:Polr1f
uniprot id: A6HB88
uniprot id: D4ADH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

10116:Mmp8
gene id: 10116:Mmp8
uniprot id: O88766
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 3 Ca(2+) ions per subunit.
messages: Can degrade fibrillar type I, II, and III collagens.
messages: Cannot be activated without removal of the activation peptide.
messages: Cytoplasmic granule
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: extracellular matrix

10116:Gpr89b
gene id: 10116:Gpr89b
uniprot id: F1LTD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

10116:Smg6
gene id: 10116:Smg6
uniprot id: A6HGP2
uniprot id: D4A589
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini.
messages: Plays a role in nonsense-mediated mRNA decay.
messages: The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion.
messages: cytosol
messages: nucleolus
messages: telomere

10116:Milr1
gene id: 10116:Milr1
uniprot id: Q62875
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity).
messages: Mast cell-specific. Expressed in primary and transformed mast cells.
messages: Monomer. Interacts (tyrosine-phosphorylated) with PTPN6, PTPN11 and INPP5D.
messages: N-glycosylated.
messages: Up-regulated in response to mast cell activation.

10116:Micall1
gene id: 10116:Micall1
uniprot id: D3ZQL6
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homooligomer (Probable). Interacts (via NPF1 motif) with EHD1 (via EH domain); the interaction is direct and probably recruits EHD1 to membranes. Interacts with EHD3 (via EH domain). Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits MICALL1 to membranes. Interacts with ACAP2; the interaction is indirect through RAB35. Interacts with RAB8A (GTP-bound form); regulates RAB8A association with recycling endosomes. Interacts with RAB13 (GTP-bound form). Interacts with ARF6 (GTP-bound form). Interacts with PACSIN2 (via the SH3 domain). Interacts with DPYSL2.
messages: Late endosome membrane
messages: Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth.
messages: Probably exists in a closed and an opened conformation due to interaction of the C-terminal RAB-binding domain (RBD), also described as bivalent Mical/EHBP Rab binding (bMERB) domain, with the N-terminal calponin-homology (CH) domain. The conformational change is regulated by RAB13 and may modulate MICALL1 interactions with functional partners (By similarity).
messages: Recycling endosome membrane

10116:Sel1l2
gene id: 10116:Sel1l2
uniprot id: Q5XI05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sel-1 family.
messages: Membrane

10116:Kdr
gene id: 10116:Kdr
uniprot id: A0A9K3Y7B7
uniprot id: O08775
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-947 is important for interaction with SH2D2A/TSAD and VEGFA-mediated reorganization of the actin cytoskeleton. Phosphorylation at Tyr-1171 is important for interaction with PLCG1 and SHB. Phosphorylation at Tyr-1210 is important for interaction with NCK1 and FYN. Dephosphorylated by PTPRB. Dephosphorylated by PTPRJ at Tyr-797, Tyr-947, Tyr-992, Tyr-1050, Tyr-1055, Tyr-1171 and Tyr-1210 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endoplasmic reticulum
messages: Expressed in the post-pubertal mammary glands.
messages: Homodimer in the presence of bound dimeric VEGFA, VEGFC or VEGFD ligands; monomeric in the absence of bound ligands. Can also form heterodimers with FLT1/VEGFR1 and KDR/VEGFR2. Interacts (tyrosine phosphorylated) with LFYN, NCK1, PLCG1. Interacts (tyrosine-phosphorylated active form preferentially) with DAB2IP (via C2 domain and active form preferentially); the interaction occurs at the late phase of VEGFA response and inhibits KDR/VEGFR2 activity. Interacts with SHBSH2D2A/TSAD, GRB2, MYOF, CBL and PDCD6. Interacts (via C-terminus domain) with ERN1 (via kinase domain); the interaction is facilitated in a XBP1- and vascular endothelial growth factor (VEGF)-dependent manner in endothelial cells (By similarity). Interacts (via juxtamembrane region) with chaperone PDCL3 (via thioredoxin fold region); the interaction leads to increased KDR/VEGFR2 abundance through inhibition of its ubiquitination and degradation (By similarity). Interacts (tyrosine phosphorylated) with CCDC88A/GIV (via SH2-like region); binding requires autophosphorylation of the KDR/VEGFR2 C-terminal region (By similarity). Interacts with isoform 2 of BSG (By similarity). Interacts with SLC31A1; this interaction is induced upon VEGFA stimulation leading to SLC31A1 and KDR subsequent co-internalization to early endosomes, thereby activating KDR downstream signaling in endothelial cells (By similarity).
messages: Increases during pregnancy (1.6-fold at 4 days) and lactation (3.8-fold at 7 days). Decreases in the early phases of involution (45%, 50% and 34% on days 1, 2, and 3 respectively).
messages: Membrane
messages: N-glycosylated.
messages: Nucleus
messages: Present in an inactive conformation in the absence of bound ligand. Binding of VEGFA, VEGFC or VEGFD leads to dimerization and activation by autophosphorylation on tyrosine residues. May be regulated by hydrogen sulfide (H(2)S) levels via a sensitive intracellular disulfide bond (By similarity).
messages: The inhibitory disulfide bond between Cys-1020 and Cys-1041 may serve as a specific molecular switch for H(2)S-induced modification that regulates KDR/VEGFR2 function.
messages: The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFC binding.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC (By similarity).
messages: Ubiquitinated. Tyrosine phosphorylation of the receptor promotes its poly-ubiquitination, leading to its degradation via the proteasome or lysosomal proteases (By similarity).

10116:Dao
gene id: 10116:Dao
uniprot id: O35078
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAMOX/DASOX family.
messages: Homodimer.
messages: Peroxisome
messages: Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.

10116:Eif2b1
gene id: 10116:Eif2b1
uniprot id: A6J0Y3
uniprot id: Q64270
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

10116:Oxtr
gene id: 10116:Oxtr
uniprot id: A6IBN2
uniprot id: P70536
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

10116:Cort
gene id: 10116:Cort
uniprot id: A6IU99
uniprot id: Q62949
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the somatostatin family.
messages: Interneurons in the cerebral cortex and hippocampus.
messages: Neuropeptide with neuronal depressant and sleep-modulating properties.
messages: Secreted
messages: There is a transient increase in cortistatin-expressing cells in the second postnatal week in all cortical areas and in the dentate gyrus. A transient expression is observed in the hilar region at P16.

10116:Pcsk4
gene id: 10116:Pcsk4
uniprot id: Q78EH2
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S8 family. Furin subfamily.
messages: Expressed abundantly in the testis. High levels seen in germ cells but not in Leydig, Sertoli or peritubular cells. Expressed in the pachytene spermatocytes and the round spermatids but not in the elongating spermatids. May be expressed within hormonally stimulated ovaries.
messages: First expressed postnatally between days 19 and 22 coinciding with the early stages of spermiogenesis. The levels increase up to postnatal day 60.
messages: N-glycosylated.
messages: Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (By similarity). May also participate in folliculogenesis in the ovaries (By similarity).
messages: Synthesized in the endoplasmic reticulum as a zymogen, is matured by autocatalytic cleavage between the prodomain and the catalytic domain.
messages: The proPCSK4 form interacts with HSPA5; the interaction takes place at the endoplasmic reticulum.
messages: acrosome membrane

10116:Adora3
gene id: 10116:Adora3
uniprot id: A6HUN6
uniprot id: P28647
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed during spermiogenesis.
messages: Membrane
messages: Phosphorylation on Thr-318 and Thr-319 may be crucial for rapid desensitization. Phosphorylation on Thr-318 may be necessary for phosphorylation on Thr-319 to occur.
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase (PubMed:1323836). May play a role during reproduction (PubMed:1647979).
messages: Testis, particularly in spermatocytes and spermatids but not in spermatogonia. Low levels in the brain.

10116:Plcd1
gene id: 10116:Plcd1
uniprot id: A0A8I5Y0I7
uniprot id: P10688
names: Cofactor
names: Function
names: Subunit
messages: Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.
messages: Binds 5 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.
messages: Interacts with TGM2.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:16000311). Essential for trophoblast and placental development (By similarity). Binds phosphatidylinositol 4,5-bisphosphate (By similarity).

10116:Ebp
gene id: 10116:Ebp
uniprot id: A6KP43
uniprot id: Q9JJ46
names: Activity Regulation
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the EBP family.
messages: Binds to the phenylalkylamine calcium-ion antagonist emopamil, an anti-ischemic drug.
messages: Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Enzymatic activity is induced by 25-hydroxycholesterol, cholestyramine and lovastatin.
messages: Expressed in liver.
messages: Expression in liver is reduced by 70% in 2 years old rats compare to 3 weeks old.
messages: Membrane
messages: Nucleus envelope

10116:Vps16
gene id: 10116:Vps16
uniprot id: A6HQ90
uniprot id: F7FA01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

10116:Bckdha
gene id: 10116:Bckdha
uniprot id: B1WBN3
uniprot id: P11960
uniprot id: Q5EB89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BCKDHA family.
messages: Heterotetramer of 2 alpha/BCKDHA and 2 beta chains/BCKDHB that forms the branched-chain alpha-keto acid decarboxylase (E1) component of the BCKD complex. The branched-chain alpha-ketoacid dehydrogenase is a large complex composed of three major building blocks E1, E2 and E3. It is organized around E2, a 24-meric cubic core composed of DBT, to which are associated 6 to 12 copies of E1, and approximately 6 copies of the dehydrogenase E3, a DLD dimer.
messages: Mitochondrion matrix
messages: Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction.

10116:Apc2
gene id: 10116:Apc2
uniprot id: A0A0G2JZW4
names: Similarity
messages: Belongs to the adenomatous polyposis coli (APC) family.

10116:Stau2
gene id: 10116:Stau2
uniprot id: Q68SB1
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Expressed in both somata and dendrites of hippocampal neurons.
messages: Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with the exportin XPO5. This requires RNA and RAN bound to GTP (By similarity). Interacts with microtubules. Isoform 2 and isoform 3 may also interact with ribosomes, and this association is independent of translation. Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (By similarity).
messages: Nucleus
messages: RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body.
messages: The DRBM 3 domain appears to be the major RNA-binding determinant (By similarity). This domain also mediates interaction with XPO5 and is required for XPO1/CRM1-independent nuclear export.
messages: XPO1/CRM1-dependent nuclear export is mediated by residues 4-14 and is abrogated by mutagenesis of Ile-4 or Leu-12.
messages: nucleolus

10116:Tmem176a
gene id: 10116:Tmem176a
uniprot id: A6K0J1
uniprot id: Q4G068
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM176 family.
messages: Interacts with MCOLN2.
messages: Membrane

10116:Ifi30
gene id: 10116:Ifi30
uniprot id: Q499T2
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GILT family.
messages: Both precursor form and mature form have thiol reductase activity.
messages: Dimer; disulfide-linked.
messages: Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity).
messages: Lysosome
messages: N-glycosylated. Sugar chains contain mannose-6-phosphate (By similarity).
messages: Secreted
messages: Synthesized as a 35 kDa precursor which is then processed into the mature 30 kDa form via cleavage of N-terminal and C-terminal propeptides. Processing of the precursor is mediated by multiple lysosomal proteases (By similarity).

10116:Osbpl7
gene id: 10116:Osbpl7
uniprot id: A6HIJ1
uniprot id: D4A0G0
names: Similarity
messages: Belongs to the OSBP family.

10116:Chst9
gene id: 10116:Chst9
uniprot id: A0A8I5ZVI1
uniprot id: F1M862
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

10116:Sft2d1
gene id: 10116:Sft2d1
uniprot id: A6KK24
uniprot id: Q5U3Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

10116:Nasp
gene id: 10116:Nasp
uniprot id: A0A8I6AFA6
uniprot id: A6JZ86
uniprot id: Q66HD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NASP family.
messages: Binds to linker H1 histones but not to core histones (By similarity). Interacts with histones H2A, H2B, H3 and H4 (By similarity). Interacts with histone H3.3 (By similarity). Also binds to HSP90 in the cytoplasm. This interaction stimulates binding of NASP to H1-6/H1T (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.

10116:Or5l14b
gene id: 10116:Or5l14b
uniprot id: D4A9G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Nrtn
gene id: 10116:Nrtn
uniprot id: M0RBQ2
uniprot id: Q811Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

10116:C8b
gene id: 10116:C8b
uniprot id: A6JRT7
uniprot id: P55314
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b sequentially binds C6, C7, C8 and multiple copies of the pore-forming subunit C9 (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

10116:Cxcl10
gene id: 10116:Cxcl10
uniprot id: P48973
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: In the central nervous system, CXCL10 is predominantly localized to activated neurons (PubMed:30448292). Expressed in both microglia and astrocytes (PubMed:30257241).
messages: Monomer, dimer, and tetramer. Interacts with CXCR3 (via N-terminus).
messages: Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity) (PubMed:30257241, PubMed:30448292).
messages: Secreted

10116:Epn1
gene id: 10116:Epn1
uniprot id: A6KNR8
uniprot id: O88339
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the epsin family.
messages: Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:11161217). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (PubMed:9723620, PubMed:12353027). Regulates receptor-mediated endocytosis (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Monomer. Binds ITSN1 (By similarity). Binds clathrin, ZBTB16/ZNF145, AP2A1 and AP2A2. Binds ubiquitinated proteins. Interacts with RALBP1 in a complex also containing NUMB and TFAP2A during interphase and mitosis. Interacts with AP2B1. Interacts with UBQLN2 (By similarity). Interacts with REPS2; the interaction is direct (By similarity). Interacts with EPS15; the interaction is direct (By similarity). Interacts with ENTREP1 (By similarity).
messages: Nucleus
messages: Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation.
messages: The DPW repeat domain is involved in AP2A2 and clathrin binding.
messages: The NPF repeat domain is involved in EPS15 binding.
messages: The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1.
messages: Ubiquitinated.
messages: Ubiquitously expressed (PubMed:9723620). Detected in liver, spleen and testis, and weakly in lung and thymus (at protein level) (PubMed:10393179).
messages: clathrin-coated pit

10116:Mgat4d
gene id: 10116:Mgat4d
uniprot id: Q4V8F8
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 54 family.
messages: Detected in the Golgi apparatus of pachytene spermatocytes beginning at stage VII and extending up to stage XIV. Detected in the Golgi apparatus of spermatids at steps 1-15 of spermatogenesis.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: May play a role in male spermatogenesis. In vitro acts as inhibitor of MGAT1 activity causing cell surface proteins to carry mainly high mannose N-glycans. The function is mediated by its lumenal domain and occurs specifically in the Golgi. A catalytic glucosyltransferase activity is not detected. May be involved in regulation of Sertoli-germ cell interactions during specific stages of spermatogenesis.
messages: May self-associate; specifically in the endoplasmic reticulum prior to its translocation to the Golgi. Interacts with MGAT1, MGAT3 and MAN2A2; may interact with MGTA1 specifically in the Golgi.
messages: N-glycosylated. O-glycosylated; further modified with terminal sialic acid residues.
messages: Testis.

10116:Alg3
gene id: 10116:Alg3
uniprot id: M0R7D2
uniprot id: Q5M7T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:Rnft2
gene id: 10116:Rnft2
uniprot id: A6J1M0
uniprot id: D3ZTN5
names: Subcellular Location Annotation
messages: Membrane

10116:LOC103690821
gene id: 10116:LOC103690821
uniprot id: A6JMH4
uniprot id: P62893
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL39 family.
messages: Component of the large ribosomal subunit (By similarity). Interacts with IMPACT (By similarity).
messages: Cytoplasm
messages: RNA-binding component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: This protein is the smallest and one of the most basic of the proteins in liver ribosomes.

10116:Pdhb
gene id: 10116:Pdhb
uniprot id: P49432
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterotetramer of two PDHA1 and two PDHB subunits. The heterotetramer interacts with DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules. Interacts with DLAT.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

10116:Wfdc2
gene id: 10116:Wfdc2
uniprot id: Q8CHN3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Broad range protease inhibitor.
messages: Homotrimer; disulfide-linked.
messages: Secreted

10116:Hemgn
gene id: 10116:Hemgn
uniprot id: Q6AZ54
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At 9 dpc expressed in extraembryonic mesodermal layers with its prospective blood islands. Expressed in blood islands at day 12 dpc. Expressed by the intraembryonic primary ectoderm including the primitive streak at day 9 dpc. Expressed in the fetal liver and in circulating cells at 17 dpc, the liver expression disappear around birth (at protein level).
messages: Expressed by bone marrow cells and osteoblasts. Also expressed by ameloblasts in tooth enamel (at protein level). Expressed in enamel organ, ameloblasts, spleen, bone marrow cells and osteoblasts.
messages: Nucleus
messages: Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) (By similarity).

10116:Dync1i1
gene id: 10116:Dync1i1
uniprot id: A0A173DW29
uniprot id: A0A8I6A2D5
uniprot id: A6IDU1
uniprot id: G3V792
uniprot id: Q63100
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
messages: Belongs to the dynein intermediate chain family.
messages: Cytoplasm
messages: High levels seen in the brain and testis, while a lower level expression is seen in the liver, spleen, kidney, lung, skeletal muscle and heart.
messages: Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Isoform 1, isoform 2 and isoform 3 interact with DYNC1H1. Isoform 1, isoform 2 and isoform 3 interact with DYNLT3. Isoform 1, isoform 2 and isoform 3 interact with DYNLT1. Interacts with DCTN1.
messages: kinetochore
messages: spindle pole

10116:Cldn1
gene id: 10116:Cldn1
uniprot id: P56745
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and PATJ. Interacts with OCLN, CD81, CLDN4, CLDN6 and CLDN9.
messages: Cell membrane
messages: Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (By similarity).
messages: Detected in epididymis (at protein level). Detected in testis and epididymis.
messages: tight junction

10116:Pabir2
gene id: 10116:Pabir2
uniprot id: A6KUJ4
names: Similarity
messages: Belongs to the FAM122 family.

10116:Extl2
gene id: 10116:Extl2
uniprot id: B1WC59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:Or5w13
gene id: 10116:Or5w13
uniprot id: D4AAC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Plekha4
gene id: 10116:Plekha4
uniprot id: P60669
names: Function
names: Subcellular Location Annotation
messages: Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides.
messages: Cytoplasm
messages: Membrane

10116:Polr2j
gene id: 10116:Polr2j
uniprot id: A6J085
uniprot id: D3ZQI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

10116:Peds1
gene id: 10116:Peds1
uniprot id: B0BN29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

10116:Mcm8
gene id: 10116:Mcm8
uniprot id: D3ZVK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Probably by regulating HR, plays a key role during gametogenesis. Stabilizes MCM9 protein.
messages: Component of the MCM8-MCM9 complex, which forms a hexamer composed of MCM8 and MCM9. Interacts with the DNA mismatch repair (MMR) complex composed at least of MSH2, MSH3, MSH6, PMS1 and MLH1. Interacts with RAD51; the interaction recruits RAD51 to DNA damage sites. Interacts with the MRN complex composed of MRE11, RAD50 and NBN/NBS1. Interacts with CDC6 and ORC2. Interacts with HROB; the interaction recruits the MCM8-MCM9 complex to DNA damage sites (By similarity).
messages: Nucleus

10116:Ntrk3
gene id: 10116:Ntrk3
uniprot id: Q03351
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds SH2B2 (PubMed:9856458). Interacts with SQSTM1 and KIDINS220 (PubMed:12471037, PubMed:15167895). Interacts with PTPRS (PubMed:17967490). Interacts with MAPK8IP3/JIP3 (PubMed:21775604).
messages: Ligand-mediated auto-phosphorylation.
messages: Membrane
messages: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). NTRK3 isoforms containing insertions within the kinase domain can autophosphorylate in response to NTF3/neurotrophin-3, but cannot mediate downstream phenotypic responses (PubMed:8494647, PubMed:8494648).
messages: Widely expressed, mainly in the nervous tissue.

10116:Zpbp
gene id: 10116:Zpbp
uniprot id: A0A8J8XCE4
uniprot id: A6KJ99
uniprot id: Q6AXU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted
messages: acrosome

10116:Cyb5b
gene id: 10116:Cyb5b
uniprot id: A6IYZ3
uniprot id: P04166
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b5 family.
messages: Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MTARC2.
messages: Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.
messages: Mitochondrion outer membrane

10116:Defal1
gene id: 10116:Defal1
uniprot id: Q4JEI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Antiparallel homodimer; disulfide-linked.
messages: Belongs to the alpha-defensin family.
messages: Intestinal defense peptide (PubMed:23380721, PubMed:28345637). Has potent antibacterial activity against Gram-negative bacteria E.coli O157:H7, S.typhimurium DT104, and K.pneumoniae; and against Gram-positive bacteria S.aureus, methicillin-resistant S.aureus and L.monocytogenes (PubMed:23380721, PubMed:28345637). Remains active in the presence of NaCl and Mg(2+) (PubMed:23380721). Probably functions by disrupting bacterial membrane integrity (PubMed:28345637). However, does not show cytotoxic activity towards human intestinal cells (PubMed:23380721).
messages: Secreted
messages: Specifically expressed in small intestine (jejunum and ileum) (PubMed:15494476, PubMed:23380721). Probably expressed by Paneth cells at the base of intestinal crypts (PubMed:23380721). Coexpressed with MMP7 in small intestine (PubMed:23380721).

10116:Arfgap3
gene id: 10116:Arfgap3
uniprot id: Q4KLN7
names: Activity Regulation
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2).
messages: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity).
messages: Golgi apparatus membrane

10116:Ccdc181
gene id: 10116:Ccdc181
uniprot id: Q6AYN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC181 family.
messages: Homodimer. Interacts with HOOK1. Interacts with HOOK2. Interacts with HOOK3.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton
messages: flagellum

10116:Slc7a5
gene id: 10116:Slc7a5
uniprot id: A6IZQ4
uniprot id: Q63016
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (PubMed:9726963, PubMed:11311135). Interacts with LAPTM4B; this recruits the heterodimer formed by SLC3A2 and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (By similarity).
messages: Expressed in hepatoma but not in normal liver. Also expressed in placenta, testis, brain, ovary, spleen, mammary gland, and uterus. In brain expressed on capillary endothelia in cerebral cortex. Expressed in jejunum mucosa and the epithelial cells of the jejunum, ileum and colon. Also expressed in the intestinal epithelial cell line IEC-6. Expressed in the brain, retina, inner blood-retinal barrier of retina, retinal vascular endothelial cells, and in the retinal capillary endothelial cell line TR-iBRB2.
messages: Expression induced in normal hepatic cells cultured in arginine-depleted medium.
messages: L-leucine uptake by TR-iBRB2 cells was inhibited by L-leucine, L-phenylalanine, L-methionine, L-isoleucine, L-valine, L-tyrosine, L-tryptophan, D-leucine, D-phenylalanine, D-methionine and by 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH) (a specific inhibitor of system L transport).
messages: Lysosome membrane
messages: Membrane
messages: The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, histidine, methionine, valine and alanine (By similarity). The heterodimer with SLC3A2 mediates the uptake of leucine, isoleucine and tryptophan (PubMed:9726963, PubMed:11311135, PubMed:12614332, PubMed:15980244). Functions as an amino acid exchanger (By similarity). May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (By similarity). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (Probable). Can mediate the transport of thyroid hormones diiodothyronine (T2), triiodothyronine (T3) and thyroxine (T4) across the cell membrane. When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (By similarity).

10116:Wrn
gene id: 10116:Wrn
uniprot id: F1LTH9
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

10116:Ctnna1
gene id: 10116:Ctnna1
uniprot id: F7F7X1
uniprot id: Q5U302
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

10116:Olr1343
gene id: 10116:Olr1343
uniprot id: A6JQU4
uniprot id: D3ZG63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Sfxn4
gene id: 10116:Sfxn4
uniprot id: A0A8I6GFL8
uniprot id: A6JIB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

10116:Cga
gene id: 10116:Cga
uniprot id: A0A0F7RQ24
uniprot id: P11962
uniprot id: Q6P509
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Secreted
messages: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

10116:Olr1135
gene id: 10116:Olr1135
uniprot id: M0R8T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Lipn
gene id: 10116:Lipn
uniprot id: A0A0G2K430
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

10116:Arhgap35
gene id: 10116:Arhgap35
uniprot id: P81128
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with RASA1 (By similarity). Interacts with the general transcription factor GTF2I, the interaction sequesters GTF2I in the cytoplasm (By similarity).
messages: N-terminal part (1-266) has GTPase activity. Required for proper cellular localization.
messages: Nucleus
messages: Phosphorylation of Tyr-1105 by PTK6 promotes the association with RASA1, inactivating RHOA while activating RAS. Phosphorylation at Tyr-308 by PDGFRA inhibits binding to GTF2I (By similarity). Phosphorylated by PRKCA at Ser-1221 and Thr-1226, induces relocalization from the cytoplasm to regions of plasma membrane ruffling and prevents the binding and substrate specificity regulation by phospholipids (By similarity). In brain, phosphorylated by FYN and SRC (By similarity). During focal adhesion formation, phosphorylated by MAPK1 and MAPK3 at the C-terminal region, probably at Ser-1451, Ser-1476, Thr-1480 and Ser-1483. Phosphorylation by MAPK1 and MAPK3 inhibits GAP function and localizes ARGHAP35 away from newly forming focal adhesions and stress fibers in cells spreading on fibronectin (PubMed:20439493). Phosphorylation at Ser-1476 and Thr-1480 by GSK3B requires priming by MAPK and inhibits RhoGAP activity and modulates polarized cell migration (By similarity).
messages: Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:9852136, PubMed:20439493). This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (PubMed:9852136, PubMed:20439493). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (By similarity).
messages: The pG1 pseudoGTPase domain does not bind GTP.
messages: Ubiquitously expressed.
messages: cilium basal body

10116:Cox8a
gene id: 10116:Cox8a
uniprot id: A6HZN8
uniprot id: P80433
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

10116:Cfap45
gene id: 10116:Cfap45
uniprot id: A0A0G2QC12
uniprot id: A6JG64
uniprot id: G3V739
names: Similarity
messages: Belongs to the CFAP45 family.

10116:Dysf
gene id: 10116:Dysf
uniprot id: A0A0G2K7B6
uniprot id: A0A8I5Y164
uniprot id: A0A8I5ZKQ3
uniprot id: A0A8I6GEZ7
uniprot id: A6IAQ5
uniprot id: D4A6X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

10116:Fam3b
gene id: 10116:Fam3b
uniprot id: A6IQG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

10116:Glb1l
gene id: 10116:Glb1l
uniprot id: A0A8I5ZK37
uniprot id: B1WBS6
uniprot id: F7FBB9
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

10116:Fxyd6
gene id: 10116:Fxyd6
uniprot id: A6J439
uniprot id: Q91XV6
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FXYD family.
messages: Expressed in the neuronal fibers of the medial part of lateral habenula nucleus, thalamus, hypothalamus, stria terminalis, zona incerta, amygdaloid body and cingulum, olfactory bulb, hippocampus, cerebral cortex and cerebellum. In the cerebellum there is a predominant expression pattern in the granule layer of lobules VI-IX of the posterior lobe.
messages: Membrane

10116:Htt
gene id: 10116:Htt
uniprot id: A0A8I6AXC3
uniprot id: A6IK16
uniprot id: G3V9P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the huntingtin family.
messages: Cytoplasm
messages: May play a role in microtubule-mediated transport or vesicle function.
messages: Nucleus

10116:Hexim2
gene id: 10116:Hexim2
uniprot id: A6HJQ2
uniprot id: F6T841
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

10116:Lpcat3
gene id: 10116:Lpcat3
uniprot id: A6ILI9
uniprot id: Q5FVN0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle. Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (By similarity). Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency. Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus. Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Down-regulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins. In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membra…
messages: Membrane
messages: The di-lysine motif confers endoplasmic reticulum localization.

10116:Tfrc
gene id: 10116:Tfrc
uniprot id: Q99376
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity).
messages: Homodimer; disulfide-linked. Binds one transferrin molecule per subunit. Interacts with SH3BP4 (By similarity). Interacts with STEAP3; facilitates TFRC endocytosis in erythroid precursor cells (By similarity).
messages: In testis, expressed in Sertoli cells, peritubular myoid cells and in germinal cells. Highest levels in Sertoli cells.
messages: Melanosome
messages: N- and O-glycosylated, phosphorylated and palmitoylated.
messages: Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation (By similarity). Stearoylation does not affect iron uptake (By similarity).

10116:Hcfc1r1
gene id: 10116:Hcfc1r1
uniprot id: Q80V38
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with HCFC1.
messages: Nucleus
messages: Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus (By similarity).

10116:Jmjd6
gene id: 10116:Jmjd6
uniprot id: Q6AYK2
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the JMJD6 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization (By similarity). Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting (By similarity). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation. Demethylates other arginine methylated-proteins such as ESR1. Has no histone lysine demethylase activity (By similarity). Required for differentiation of multiple organs during embryogenesis. Acts a…
messages: Homooligomerizes; requires lysyl-hydroxylase activity (By similarity). Interacts with LUC7L2, LUC7L3 and U2AF2/U2AF65 (By similarity). Interacts with CDK9 and CCNT1; the interaction is direct with CDK9 and associates the P-TEFb complex when active. Interacts (via JmjC and N-terminal domains) with BRD4 (via NET domain); the interaction is stronger in presence of ssRNA and recruits JMJD6 on distal enhancers (By similarity).
messages: Hydroxylates its own N-terminus; hydroxylation is required for homooligomerization.
messages: The nuclear localization signal motifs are necessary and sufficient to target it into the nucleus.
messages: nucleolus
messages: nucleoplasm

10116:Ifna2
gene id: 10116:Ifna2
uniprot id: A0A0G2K3I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

10116:S100pbp
gene id: 10116:S100pbp
uniprot id: A6ISH8
uniprot id: D3ZSX9
names: Subcellular Location Annotation
messages: Nucleus

10116:Krt16
gene id: 10116:Krt16
uniprot id: Q6IFU9
names: Similarity
messages: Belongs to the intermediate filament family.

10116:Rasgrp4
gene id: 10116:Rasgrp4
uniprot id: Q8R5I4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the RASGRP family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed by mast cells and their progenitors (at protein level).
messages: Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.
messages: The phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG.

10116:Filip1
gene id: 10116:Filip1
uniprot id: Q8K4T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the FILIP1 family.
messages: By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of Filamin A.
messages: Expressed in muscle tissue, including heart. Found in cortical ventricular zone.
messages: Interacts with FLNA. Interacts with RHOD (in GTP-bound form).
messages: cytoskeleton
messages: stress fiber

10116:Yap1
gene id: 10116:Yap1
uniprot id: Q2EJA0
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Attenuates p73-mediated cell death signaling in transcriptional repression-induced atypical death (TRIAD) of neurons.
messages: Belongs to the YAP1 family.
messages: Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif (By similarity). The phosphorylated form interacts with YWHAB. Interacts (via WW domains) with LATS1 (via PPxY motif 2). Interacts with LATS2. Interacts (via WW domain 1) with ERBB4 (via PPxY motif 2). Interacts with TEAD1, TEAD2, TEAD3 and TEAD4. Interacts with TP73. Interacts with RUNX1. Interacts with HCK. Interacts (via WW domains) with PTPN14 (via PPxY motif 2); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional coactivator activity (By similarity). Interacts (when phosphorylated at Ser-112) with SMAD2, SMAD3 and WWTR1 (By similarity). Interacts with PRRG2 (via cytoplasmic domain) (By similarity). Interacts (via WW domains) with PRRG4 (via cytoplasmic domain) (By similarity). Interacts (phosphorylated) with CLDN18; the interaction sequesters YAP1 away from the nucleus and thereby restricts transcription of YAP1 target genes (By similarity). Interacts with SMAD1 (By similarity).
messages: Cell junction
messages: Cytoplasm
messages: Down-regulated by alpha-amanitin (AMA).
messages: Highly specific to cortical neurons.
messages: Nucleus
messages: Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation. Phosphorylated by ABL1; leading to YAP1 stabilization, enhanced interaction with TP73 and recruitment onto proapoptotic genes; in response to DNA damage. Phosphorylation at Ser-366 and Ser-369 by CK1 is triggered by previous phosphorylation at Ser-363 by LATS proteins and leads to YAP1 ubiquitination by SCF(beta-TRCP) E3 ubiquitin ligase and subsequent degradation (By similarity). Phosphorylated at Thr-104, Thr-136, Ser-333 and Thr-378 by MAPK8/JNK1 and MAPK9/JNK2, which is required for the regulation of apoptosis by YAP1 (By similarity).
messages: The first coiled-coil region mediates most of the interaction with TEAD transcription factors.
messages: Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization. Plays a key role in controlling cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (By similarity). Suppresses ciliogenesis via acting as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity). In conjunction with WWTR1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity).
messages: Ubiquitinated by SCF(beta-TRCP) E3 ubiquitin ligase.

10116:Abcb4
gene id: 10116:Abcb4
uniprot id: Q08201
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts. Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes. Required for proper phospholipid bile formation. Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner. May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane. In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts. Does not confer multidrug resistance.
messages: Expressed in the liver (PubMed:15159385). Expressed in hepatocytes (PubMed:7948020, PubMed:10067174).
messages: Glycosylated.
messages: Interacts with HAX1 (PubMed:15159385). May interact with RACK1 (By similarity).
messages: Membrane raft
messages: Phosphorylated. Phosphorylation is required for PC efflux activity. Phosphorylation occurs on serine and threonine residues in a protein kinase A- or C-dependent manner. May be phosphorylated on Thr-41 and Ser-46.
messages: Translocation activity is inhibited by the ATPase inhibitor vanadate and the calcium channel blocker verapamil. Translocation activity is enhanced by the addition of the bile salt taurocholate.
messages: clathrin-coated vesicle

10116:Nab2
gene id: 10116:Nab2
uniprot id: A0A8I6B288
uniprot id: A6HQW4
uniprot id: A6HQW5
uniprot id: D4A4F4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

10116:Capza2
gene id: 10116:Capza2
uniprot id: A6IE30
uniprot id: Q3T1K5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity). Directly interacts with CRACD; this interaction decreases binding to actin (By similarity).

10116:Nlrc3
gene id: 10116:Nlrc3
uniprot id: A0A8I5ZRD5
names: Subcellular Location Annotation
messages: Inflammasome

10116:Asb2
gene id: 10116:Asb2
uniprot id: A6JEM4
uniprot id: Q5U2S6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: Component of a probable ECS E3 ubiquitin-protein ligase complex which contains CUL5, either RBX1 or RNF7/RBX2, Elongin BC complex (ELOB and ELOC) and ASB2. Interacts with SKP2. Through its interaction with SKP2, likely to bridge the formation of dimeric E3-ubiquitin-protein ligase complexes composed of an ECS complex and an SCF(SKP2) complex. Interacts with JAK2; the interaction targets JAK2 for Notch-mediated proteasomal degradation. Interacts with TCF3/E2A; the interaction is mediated by SKP2 and targets TCF3 for Notch-mediated proteasomal degradation (By similarity). Interacts with DES (By similarity).
messages: Monoubiquitinated.
messages: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Mediates Notch-induced ubiquitination and degradation of substrates including E2A and JAK2 (By similarity). Required during embryonic heart development for complete heart looping (By similarity). Required for cardiomyocyte differentiation (By similarity). Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA (By similarity). Also targets DES for proteasomal degradation (By similarity). Acts as a negative regulator of skeletal muscle mass (By similarity).
messages: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
messages: The UIM domain is required for monoubiquitination.
messages: Z line
messages: stress fiber

10116:Plet1
gene id: 10116:Plet1
uniprot id: A6J4D2
uniprot id: Q5HZW7
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: GPI-anchored.
messages: Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity).
messages: Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle.
messages: N-glycosylated.

10116:Cox6b1
gene id: 10116:Cox6b1
uniprot id: A0A8I6A8X0
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

10116:Ptprs
gene id: 10116:Ptprs
uniprot id: Q64605
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
messages: Binding to large heparan sulfate proteoglycan structures promotes oligomerization. Binding to chondroitin sulfate proteoglycan does not lead to oligomerization (By similarity). Interacts (via Ig-like domains) with NTRK1 and NTRK3, but does not form detectable complexes with NTRK2 (PubMed:17967490). Interacts with PPFIA1, PPFIA2 and PPFIA3 (By similarity).
messages: Cell membrane
messages: Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb (By similarity). Functions as tyrosine phosphatase (PubMed:8068021). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (By similarity).
messages: Detected in brain neocortex (at protein level) (PubMed:22519304). Detected in heart, testis and liver (PubMed:8068021). Detected at lower levels in skeletal muscle, brain, spleen and kidney (PubMed:8068021).
messages: Perikaryon
messages: Postsynaptic density
messages: axon
messages: growth cone
messages: neuron projection
messages: synaptic vesicle membrane
messages: synaptosome

10116:Rps27l
gene id: 10116:Rps27l
uniprot id: A6KEZ8
uniprot id: P24051
names: Cofactor
names: Similarity
names: Tissue Specificity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.
messages: Expressed predominantly in the striatum, hypothalamus, heart and liver and at lower levels in the cerebellum, hippocampus and pons.

10116:RGD1560212
gene id: 10116:RGD1560212
uniprot id: A6K5G7
uniprot id: A6K5G8
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

10116:Slc49a4
gene id: 10116:Slc49a4
uniprot id: Q66H95
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cleaved in lysosomes by cathepsin L between Leu-214 and Ala-261, generating a N-glycosylated N-terminal and a non-glycosylated C-terminal fragment.
messages: Lysosome membrane
messages: Mediates H(+)-dependent pyridoxine transport.

10116:Glyr1
gene id: 10116:Glyr1
uniprot id: A6K4P4
uniprot id: Q5RKH0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIBADH-related family. NP60 subfamily.
messages: Chromosome
messages: Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression. Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA. Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes. Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300. With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation. Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6.
messages: Homotetramere. Interacts with MAPK14. Interacts with KDM1B at nucleosomes; this interaction stimulates H3K4me1 and H3K4me2 demethylation. Binds to mononucleosomes. Interacts with GATA4; the interaction is required for a synergistic activation of GATA4 target genes transcription.
messages: In the dehydrogenase domain, the conserved NAD(P)H-binding sites and sequence similarity to plant dehydrogenases suggest that this protein may have oxidoreductase activity. However, since the active site is not conserved, the dehydrogenase domain seems to serve as a catalytically inert oligomerization module.
messages: Nucleus
messages: The A.T hook DNA-binding domain is required for the interaction with MAPK14.
messages: The PWWP domain is a H3 reader and strongly binds DNA.
messages: The PWWP domain probably mediates the binding to H3K36me3.

10116:Slc25a29
gene id: 10116:Slc25a29
uniprot id: A0A8L2Q298
uniprot id: A6KBH5
uniprot id: Q5HZE0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Initially, this protein was identified as a carnitine/acylcarnitine transporter (By similarity). Later, a study conducted by Palmieri and coworkers demonstrated that SLC25A29 is mainly involved in the translocation of basic amino acids (By similarity).
messages: Membrane
messages: Mitochondrial transporter of arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms. Plays a physiolocical role in the import of basic amino acids into mitochondria for mitochondrial protein synthesis and amino acid degradation.
messages: Mitochondrion inner membrane

10116:Il33
gene id: 10116:Il33
uniprot id: A6I0X6
uniprot id: Q66H70
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family. Highly divergent.
messages: Chromosome
messages: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity). Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity).
messages: Cytoplasm
messages: Forms a 1:1:1 heterotrimeric complex with its primary high-affinity receptor IL1RL1 and the coreceptor IL1RAP. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.
messages: In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or pro-inflammatory activation (By similarity).
messages: Nucleus
messages: Secreted
messages: The full-length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor. However, proteolytic processing by CELA1, CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full-length protein. May also be proteolytically processed by calpains. Proteolytic cleavage mediated by apoptotic caspases including CASP3 and CASP7 results in IL33 inactivation. In vitro proteolytic cleavage by CASP1 was reported but could not be confirmed in vivo suggesting that IL33 is probably not a direct substrate for that caspase (By similarity).
messages: The homeodomain-like HTH domain mediates nuclear localization and heterochromatin association.
messages: Vesicle
messages: secretory vesicle

10116:Rasa2
gene id: 10116:Rasa2
uniprot id: Q63713
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4) and phospholipids.
messages: Widely expressed. Higher expression in brain, placenta, and kidney.

10116:Emc2
gene id: 10116:Emc2
uniprot id: A6HRA5
uniprot id: B0BNG0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Component of the ER membrane protein complex (EMC). Interacts with WNK1 (via amphipathic alpha-helix region); promoting the ER membrane protein complex assembly by preventing EMC2 ubiquitination.
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.
messages: Ubiquitinated when soluble in the cytoplasm, leading to its degradation by the proteasome. Interaction with EMC2 prevents its ubiquitination and degradation.

10116:Vps37a
gene id: 10116:Vps37a
uniprot id: A0A8I6GCD4
uniprot id: A6JPV3
uniprot id: F7FHB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

10116:Ifi47
gene id: 10116:Ifi47
uniprot id: E9PU10
uniprot id: Q8K580
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

10116:Cx3cl1
gene id: 10116:Cx3cl1
uniprot id: O55145
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A soluble short form may be released by proteolytic cleavage from the long membrane-anchored form.
messages: Belongs to the intercrine delta family.
messages: Cell membrane
messages: Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. Regulates leukocyte adhesion and migration processes at the endothelium. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1.
messages: Highest levels in brain (neurons). Significant levels in kidney, heart, lung and adrenal gland.
messages: Monomer. Forms a ternary complex with CX3CR1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Secreted
messages: The membrane-bound form promotes adhesion of those leukocytes to endothelial cells.
messages: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils.

10116:Kcnip1
gene id: 10116:Kcnip1
uniprot id: A0A0H2UHE0
uniprot id: A0A8I6ALG6
uniprot id: A6HDH0
uniprot id: Q8R426
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the recoverin family.
messages: Cell membrane
messages: Component of heteromultimeric potassium channels (PubMed:15356203, PubMed:14980206). Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). Part of a heterooctamer composed of the tetrameric channel and four KCNIP1 chains (By similarity). Interacts with KCND3 and the N-terminal domain of KCND2. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2 (PubMed:14980206). Self-associates to form homodimers and homotetramers. Interacts with KCNIP2 isoform 3 in a calcium-dependent manner.
messages: Cytoplasm
messages: Detected in hippocampus and in the molecular layer of the dentate gyrus (at protein level) (PubMed:15356203). Isoform 1 and isoform 2 are predominantly expressed at equal levels in brain. Colocalizes with KCND3 in inhibitory interneurons in cortex and hippocampus and in striatal interneurons.
messages: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels (PubMed:14980206). Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:14980206). Modulates KCND2/Kv4.2 currents (PubMed:14980206). In vitro, modulates KCND1/Kv4.1 currents (By similarity). Increases the presence of KCND2 at the cell surface (PubMed:14980206).
messages: dendrite

10116:Glis2
gene id: 10116:Glis2
uniprot id: A6K4S5
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

10116:Get4
gene id: 10116:Get4
uniprot id: A6K1X1
uniprot id: F1LXF5
names: Similarity
messages: Belongs to the GET4 family.

10116:Or4c125
gene id: 10116:Or4c125
uniprot id: M0R482
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Dgka
gene id: 10116:Dgka
uniprot id: A0A8I6G415
uniprot id: A0A8L2QJB9
uniprot id: P51556
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the eukaryotic diacylglycerol kinase family.
messages: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:22627129). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:22627129). Also plays an important role in the biosynthesis of complex lipids. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group (By similarity). Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol (PubMed:22627129).
messages: Lymphocytes and oligodendroglial cells.
messages: Monomer.
messages: Stimulated by calcium and phosphatidylserine (By similarity). Activated by sphingosine (PubMed:22627129).
messages: cytosol

10116:Csf2ra
gene id: 10116:Csf2ra
uniprot id: Q701L2
names: Subcellular Location Annotation
messages: Membrane

10116:Aadac
gene id: 10116:Aadac
uniprot id: Q9QZH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the 'GDXG' lipolytic enzyme family.
messages: Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly (By similarity). Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.
messages: Endoplasmic reticulum membrane
messages: Highest levels in liver with lower levels in jejunum, kidney and testis.
messages: Microsome membrane

10116:Olr1239
gene id: 10116:Olr1239
uniprot id: M0RAN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Cyhr1
gene id: 10116:Cyhr1
uniprot id: P0DW88
names: Subcellular Location Annotation
messages: Membrane

10116:Havcr1
gene id: 10116:Havcr1
uniprot id: O54947
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. TIM family.
messages: Cell membrane
messages: Expressed at a low level in normal kidney but are increased dramatically in postischemic kidney. Expressed in proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in regenerating proximal tubules.
messages: Interacts with STAM. Interacts with SELPLG.
messages: Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (By similarity). Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as regulator of T-cell proliferation (By similarity). May play a role in kidney injury and repair (By similarity).

10116:Car10
gene id: 10116:Car10
uniprot id: M0R8A5
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

10116:Kdm4b
gene id: 10116:Kdm4b
uniprot id: A6KQY4
uniprot id: M0RB75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

10116:Ptgr1
gene id: 10116:Ptgr1
uniprot id: P97584
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.
messages: NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (By similarity). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (PubMed:11524419) (By similarity). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). Plays a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:11524419). Inactivates 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (PubMed:11524419).
messages: Up-regulated by 1,2-dithiole-3-thione (D3T).

10116:Cdh17
gene id: 10116:Cdh17
uniprot id: P55281
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine.
messages: Cell membrane
messages: Liver and intestine.
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

10116:Or2t47d
gene id: 10116:Or2t47d
uniprot id: A0A8I6ABE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Fpr1
gene id: 10116:Fpr1
uniprot id: A6KB73
uniprot id: D4A7Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

10116:Arl4a
gene id: 10116:Arl4a
uniprot id: P61214
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed strongly in embryo at 7 dpc. Expressed slightly in embryo at 11, 15 and 17 dpc.
messages: Expressed strongly in testis and liver. Expressed slightly in heart, spleen, lung and kidney.
messages: Interacts with CYTH2. Interacts with KPNA2; the interaction is direct. Does not interact with ARL4A (By similarity).
messages: Myristoylated.
messages: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity).
messages: nucleolus

10116:Mrps5
gene id: 10116:Mrps5
uniprot id: A6HQ22
uniprot id: D3ZYT2
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

10116:Smc6
gene id: 10116:Smc6
uniprot id: A6HAP6
uniprot id: D4AB26
names: Subcellular Location Annotation
messages: Chromosome

10116:LOC100911047
gene id: 10116:LOC100911047
uniprot id: M0RDK0
names: Similarity
messages: Belongs to the XLR/SYCP3 family.

10116:Ubac2
gene id: 10116:Ubac2
uniprot id: A0A8I6AW27
uniprot id: A6HUK7
uniprot id: F1LQF5
names: Subcellular Location Annotation
messages: Membrane

10116:Olfm4
gene id: 10116:Olfm4
uniprot id: A6HU14
uniprot id: D3ZMI6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Pold3
gene id: 10116:Pold3
uniprot id: Q4V7D0
names: Subcellular Location Annotation
messages: Nucleus

10116:Hist1h4b
gene id: 10116:Hist1h4b
uniprot id: A6KLQ0
uniprot id: P62804
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: OGP is found in serum. A potentially OGP-specific transcript is highly expressed in spleen with lower levels in lung, liver, thymus, spinal chord, pituitary gland, adrenal gland, bone marrow and lymph nodes as well as very low levels in kidney, heart and brain.
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Secreted
messages: Stimulates osteogenesis and hematopoiesis.
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

10116:Tpx2
gene id: 10116:Tpx2
uniprot id: A0A0G2JT92
uniprot id: A6KHR8
uniprot id: D3ZA78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPX2 family.
messages: Nucleus
messages: spindle pole

10116:Rnase11
gene id: 10116:Rnase11
uniprot id: Q5GAL9
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

10116:Slc10a2
gene id: 10116:Slc10a2
uniprot id: Q62633
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Expressed mainly in ileum and kidney, low levels in cecum and proximal colon.
messages: Membrane
messages: Monomer and homodimer.
messages: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:7860756). Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate. Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids. Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (By similarity).
messages: Transcriptionally regulated increases in mRNA and protein levels at the time of weaning.

10116:Cdk5r2
gene id: 10116:Cdk5r2
uniprot id: A6JVW4
uniprot id: F1M491
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit and a regulatory subunit.
messages: Membrane

10116:Tifab
gene id: 10116:Tifab
uniprot id: Q5BK67
names: Function
names: Subunit
messages: Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA.
messages: Interacts with TIFA.

10116:Obp2b
gene id: 10116:Obp2b
uniprot id: Q63613
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

10116:Gfer
gene id: 10116:Gfer
uniprot id: Q63042
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. May have a function in liver regeneration and spermatogenesis.
messages: Homodimer; disulfide-linked (PubMed:12717032, PubMed:22948913). Interacts with CHCHD4/MIA40 (By similarity).
messages: Mitochondrion
messages: Mitochondrion intermembrane space

10116:Egfl6
gene id: 10116:Egfl6
uniprot id: A0A0G2KB47
uniprot id: A6K2H3
uniprot id: D3Z8B8
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Cdc45
gene id: 10116:Cdc45
uniprot id: A0A8I6AEM5
uniprot id: B1WBZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

10116:Mertk
gene id: 10116:Mertk
uniprot id: A6HQ37
uniprot id: P57097
names: Disease Annotation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on Tyr-744, Tyr-748 and Tyr-749 in the activation loop allowing full activity. Autophosphorylated on Tyr-867 leading to recruitment of downstream partners of the signaling cascade such as PLCG2 (By similarity).
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
messages: Cell membrane
messages: Defects in Mertk are the cause of retinal dystrophy (rdy) in the royal college of surgeons (RCS) rats.
messages: Interacts (upon activation) with TNK2; stimulates TNK2 autophosphorylation. Interacts (via N-terminus) with extracellular ligands LGALS3, TUB, TULP1 and GAS6. Interacts with VAV1 in a phosphotyrosine-independent manner. Interacts with TIMD4; this interaction enhances TIMD4-mediated efferocytosis (By similarity).
messages: Membrane
messages: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 (By similarity).

10116:Defb41
gene id: 10116:Defb41
uniprot id: Q32ZF5
names: Similarity
messages: Belongs to the beta-defensin family.

10116:Gstm6l
gene id: 10116:Gstm6l
uniprot id: A6HUV9
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

10116:Rimklb
gene id: 10116:Rimklb
uniprot id: A0A8I6A4B6
names: Similarity
messages: Belongs to the RimK family.

10116:Hoxb5
gene id: 10116:Hoxb5
uniprot id: A6HIE6
uniprot id: D3ZMA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

10116:Ctu1
gene id: 10116:Ctu1
uniprot id: B1WBV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

10116:Napb
gene id: 10116:Napb
uniprot id: F8WFM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

10116:LOC102549828
gene id: 10116:LOC102549828
uniprot id: M0R9P6
names: Similarity
messages: Belongs to the LCE family.

10116:Casp2
gene id: 10116:Casp2
uniprot id: A6IF65
uniprot id: P55215
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Forms a complex named the PIDDosome with PIDD1 and CRADD (By similarity). Interacts with NOL3 (via CARD domain); inhibits CASP2 activity in a phosphorylation-dependent manner (PubMed:16639714).
messages: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (By similarity). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (By similarity).
messages: The CARD domain mediates a direct interaction with CRADD.
messages: The mature protease can process its own propeptide, but not that of other caspases.

10116:Psme1
gene id: 10116:Psme1
uniprot id: F7F0J8
uniprot id: Q6P9V7
names: Similarity
messages: Belongs to the PA28 family.

10116:Slc5a8
gene id: 10116:Slc5a8
uniprot id: A0A8I6A218
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

10116:Ptp4a1
gene id: 10116:Ptp4a1
uniprot id: Q78EG7
names: Activity Regulation
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Brain (neurons and oligodendrocytes), skeletal muscle, regenerating liver, tumor cell lines. Expressed in enterocytes of the small intestine villi and colonic surface, zymogen cells of the stomach, proximal tubule cells of the kidney, bronchiolar epithelium, but not in esophagus and heart (at protein level).
messages: By hepatectomy, mitogens, and ischemia-reperfusion.
messages: Cell membrane
messages: Cytoplasm
messages: Early endosome
messages: Endoplasmic reticulum
messages: Expressed in fetal brain. Up-regulated during oligodendroglial differentiation. Expressed in the developing intestine, esophagus, liver, kidney and lung (at protein level).
messages: Farnesylated. Farnesylation is required for membrane targeting (By similarity).
messages: Homotrimer. Interacts with ATF5 and tubulin (By similarity).
messages: Inhibited by sodium orthovanadate and pentamidine.
messages: Nucleus
messages: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity).
messages: spindle

10116:LOC691658
gene id: 10116:LOC691658
uniprot id: A0A8I6A315
uniprot id: A0A8J8XJD4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

10116:Mapk10
gene id: 10116:Mapk10
uniprot id: A6K5V7
uniprot id: P49187
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by threonine and tyrosine phosphorylation by two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K7 phosphorylates MAPK10 on Thr-221 causing a conformational change and a large increase in Vmax for the enzyme. MAP2K4 then phosphorylates Tyr-223 resulting in a further increase in Vmax. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by HDAC9 (By similarity).
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Dually phosphorylated on Thr-221 and Tyr-223 by MAP2K4 and MAP2K7, which activates the enzyme. MAP2K7 shows a strong preference for Thr-221 while MAP2K4 phosphorylates Tyr-223 preferentially. Weakly autophosphorylated on threonine and tyrosine residues in vitro (By similarity).
messages: Interacts with MAPK8IP1/JIP-1 and MAPK8IP3/JIP-3/JSAP1 (PubMed:21076496). Interacts with SPAG9/MAPK8IP4/JIP4 (By similarity). Interacts with HDAC9 and MAPKBP1 (By similarity). Interacts with ARRB2; the interaction enhances MAPK10 activation by MAP3K5 (By similarity). Interacts with SARM1 (By similarity). Interacts with JUND; interaction is inhibited in the presence of MEN1 (By similarity).
messages: Membrane
messages: Mitochondrion
messages: Nucleus
messages: Palmitoylation regulates subcellular location and axonal development.
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.
messages: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (By similarity). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (By similarity).
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

10116:Ppm1j
gene id: 10116:Ppm1j
uniprot id: Q641Y6
names: Similarity
names: Subunit
messages: Belongs to the PP2C family.
messages: Interacts with UBE2I/UBC9.

10116:Olr1274
gene id: 10116:Olr1274
uniprot id: M0R5C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Il1rapl2
gene id: 10116:Il1rapl2
uniprot id: A0A1W2Q6G2
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

10116:Slco1a1
gene id: 10116:Slco1a1
uniprot id: A6IMP9
uniprot id: P46720
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Binds to PDZK1. Interaction with PDZK1 is required for expression on hepatocyte surface.
messages: Cell membrane
messages: Glycosylated.
messages: Highly expressed in liver and kidney, and at lower levels in brain, lung, skeletal muscle and proximal colon.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the Na(+)-independent transport of organic anions such as steroid sulfate conjugates (dehydroepiandrosterone sulfate (DHEAS), 17-beta-glucuronosyl estradiol, estrone-3-sulfate), conjugated (taurocholate) and unconjugated (cholate) bile acids, prostaglandin E2 (PGE2) and L-thyroxine T4 (PubMed:19129463). Also capable of transporting sulfobromophthalein (BSP), ouabain and gadoxetate (By similarity). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463).
messages: Membrane

10116:Lenep
gene id: 10116:Lenep
uniprot id: Q9WVB7
names: Tissue Specificity
messages: Preferentially expressed in the lens epithelial cells.

10116:Rgs2
gene id: 10116:Rgs2
uniprot id: A6ICP7
uniprot id: Q9JHX0
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with GNAQ. Does not interact with GNAI1 and GNAI3. Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha).
messages: Membrane
messages: Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.
messages: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity).
messages: nucleolus

10116:Gipc3
gene id: 10116:Gipc3
uniprot id: A6K892
names: Similarity
messages: Belongs to the GIPC family.

10116:Rftn2
gene id: 10116:Rftn2
uniprot id: A0A8I5XV77
uniprot id: A6IP14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

10116:Ctsc
gene id: 10116:Ctsc
uniprot id: A6I5Z1
uniprot id: P80067
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase C1 family.
messages: Binds 1 Cl(-) ion per heavy chain.
messages: Broadly distributed, but higher levels found in liver, spleen, intestine, lung and kidney.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.
messages: Thiol protease (PubMed:1740150). Has dipeptidylpeptidase activity (PubMed:1740150). Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate (PubMed:1740150). Can act as both an exopeptidase and endopeptidase (By similarity). Activates serine proteases such as elastase, cathepsin G and granzymes A and B (By similarity).

10116:Prkag1
gene id: 10116:Prkag1
uniprot id: P80385
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
messages: Belongs to the 5'-AMP-activated protein kinase gamma subunit family.
messages: Highly expressed in heart and brain, also found in kidney, white adipose tissue, lung and spleen.
messages: Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK. There is some ambiguity for a phosphosite: Ser-260/Thr-262.
messages: The 4 CBS domains mediate binding to nucleotides. Of the 4 potential nucleotide-binding sites, 3 are occupied, designated as sites 1, 3, and 4 based on the CBS modules that provide the acidic residue for coordination with the 2'- and 3'-hydroxyl groups of the ribose of AMP. Of these, site 4 appears to be a structural site that retains a tightly held AMP molecule (AMP 3). The 2 remaining sites, 1 and 3, can bind either AMP, ADP or ATP. Site 1 (AMP, ADP or ATP 1) is the high-affinity binding site and likely accommodates AMP or ADP. Site 3 (AMP, ADP or ATP 2) is the weakest nucleotide-binding site on the gamma subunit, yet it is exquisitely sensitive to changes in nucleotide levels and this allows AMPK to respond rapidly to changes in cellular energy status. Site 3 is likely to be responsible for protection of a conserved threonine in the activation loop of the alpha catalytic subunit through conformational changes induced by binding of AMP or ADP.
messages: The AMPK pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins of AMPK, except the presence of a non-phosphorylatable residue in place of Ser. In the absence of AMP this pseudosubstrate sequence may bind to the active site groove on the alpha subunit (PRKAA1 or PRKAA2), preventing phosphorylation by the upstream activating kinase STK11/LKB1 (By similarity).

10116:Fcer1g
gene id: 10116:Fcer1g
uniprot id: B1H251
uniprot id: P20411
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation.
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Expressed in leukocytes and pinealocytes. Expression in the pineal gland does not undergo circadian variations.
messages: IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Associates with FCGR1A to form a functional receptor complex (By similarity). The signaling subunit of immunoglobulin gamma (IgG) Fc receptor complex. As a homodimer or a heterodimer of CD247 and FCER1G, associates with the ligand binding subunit FCGR3A to form a functional receptor complex (PubMed:1825220). Associates with CLEC6A. Interacts with CLEC4E (PubMed:23921530). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with common beta chain of interleukin 3 receptor CSF2RB and recruits SYK in response to IL3 stimulation; this interaction is direct (By similarity). Interacts with CD300LH; the interaction may be indirect. Interacts with CD300LD (By similarity). Interacts with TARM1 (By similarity).
messages: Membrane

10116:Chrm3
gene id: 10116:Chrm3
uniprot id: A6KN24
uniprot id: P08483
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Homodimer; the dimers can form tetramers (By similarity). Interacts with NALCN (By similarity). Interacts with TMEM147 (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

10116:Sdhd
gene id: 10116:Sdhd
uniprot id: A6J4E0
uniprot id: Q6PCT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

10116:Ptpn3
gene id: 10116:Ptpn3
uniprot id: A6KDS9
uniprot id: F1LQQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

10116:Bdh1
gene id: 10116:Bdh1
uniprot id: A0A0G2JSH2
uniprot id: A6IRW3
uniprot id: P29147
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Expressed in liver.
messages: Homotetramer.
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Requires phosphatidylcholine as an allosteric activator for enzymatic activity.

10116:Crygf
gene id: 10116:Crygf
uniprot id: A6KFC0
uniprot id: G3V9F6
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

10116:Phc1
gene id: 10116:Phc1
uniprot id: A0A8I6AHM8
uniprot id: A6ILE3
uniprot id: D3ZVD1
names: Subcellular Location Annotation
messages: Nucleus

10116:Cux1
gene id: 10116:Cux1
uniprot id: A0A8I6G4D0
uniprot id: F1M8J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASP family.
messages: Belongs to the CUT homeobox family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Nucleus

10116:Bex2
gene id: 10116:Bex2
uniprot id: A6KT30
uniprot id: Q3MKQ1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BEX family.
messages: Cytoplasm
messages: Interacts with LMO2, possibly leading to regulate the transcriptional activity of a DNA-binding complex containing LMO2 (By similarity). Interacts with OMP (By similarity).
messages: Nucleus
messages: Regulator of mitochondrial apoptosis and G1 cell cycle. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity).
messages: The histidine cluster (His cluster) and Cys-126 mediate zinc-binding.

10116:Olr1079
gene id: 10116:Olr1079
uniprot id: A0A8I5ZX77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tesk2
gene id: 10116:Tesk2
uniprot id: Q924U5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by autophosphorylation on Ser-219.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis (By similarity).
messages: Nucleus
messages: Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells.

10116:Bpi
gene id: 10116:Bpi
uniprot id: Q6AXU0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Cytoplasmic granule membrane
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

10116:Aurka
gene id: 10116:Aurka
uniprot id: A0A8I5ZT82
uniprot id: Q3MHU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

10116:Psenen
gene id: 10116:Psenen
uniprot id: A6J9Z1
uniprot id: Q6QI68
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 3D-structure analysis of the human homolog indicates that the membrane topology differs from the predictions. Contrary to predictions, the N-terminus contains two short helices that dip into the membrane, but do not cross it. The C-terminus contains the single transmembrane helix. This gives rise to a topology where the N-terminus is cytoplasmic and the C-terminus is lumenal.
messages: Belongs to the PEN-2 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity.
messages: Golgi stack membrane
messages: Membrane
messages: The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN.

10116:Tcf12
gene id: 10116:Tcf12
uniprot id: P51514
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin, E12 and ITF2 proteins. Interacts with PTF1. Interacts with RUNX1T1. Interacts with NEUROD2 (By similarity). Interacts with BHLHA9.
messages: Isoform gamma is highly expressed in lung, kidney, spleen, and is expressed at reduced levels in heart, muscle, liver, pituitary, brain and the trigeminal ganglion. The expression of isoform alpha predominates over isoform gamma in the pituitary and the brain.
messages: Nucleus
messages: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis.

10116:Peli1
gene id: 10116:Peli1
uniprot id: A6JQ36
uniprot id: F7FFX2
uniprot id: Q562B8
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

10116:Clp1
gene id: 10116:Clp1
uniprot id: Q5PQL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity).

10116:Hao2
gene id: 10116:Hao2
uniprot id: A0A8L2UQG3
uniprot id: A6K3E3
uniprot id: Q07523
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
messages: Binds 1 FMN per subunit.
messages: Expressed in kidney.
messages: Homotetramer (PubMed:8508789). Could also form homooctamer.
messages: Is inhibited in vitro by CCPST (4-carboxy-5-(4-chlorophenyl)sulfanyl-1,2,3-thiadiazole).
messages: Oxidase that catalyzes the oxidation of medium and long chain hydroxyacids such as 2-hydroxyhexadecanoate, 2-hydroxyoctanoate, 2-hydroxyhexanoate and 2-hydroxybutanoate, to the correspondong 2-oxoacids (PubMed:15683236, PubMed:3061453, PubMed:8508789). Its role in the oxidation of 2-hydroxy fatty acids may contribute to the general pathway of fatty acid alpha-oxidation (By similarity). Can also use mandelate as substrate (PubMed:3061453). Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2 (PubMed:15683236, PubMed:3061453, PubMed:8508789).
messages: Peroxisome

10116:Med19
gene id: 10116:Med19
uniprot id: A6HMQ9
uniprot id: D3ZAP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

10116:Adgrl2
gene id: 10116:Adgrl2
uniprot id: A0A8I5ZZY9
uniprot id: A0A8I6A5I7
uniprot id: F1M7T0
uniprot id: O88923
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis.
messages: Expressed ubiquitously with highest concentrations found in placenta, kidney, spleen, ovary, heart and lung.
messages: Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety.
messages: Membrane
messages: Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.

10116:Btg4
gene id: 10116:Btg4
uniprot id: A0A9K3Y7H5
uniprot id: Q4VFT8
uniprot id: Q5M7A6
names: Similarity
messages: Belongs to the BTG family.

10116:Mical1
gene id: 10116:Mical1
uniprot id: D3ZBP4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mical family.
messages: Cytoplasm
messages: Endosome membrane
messages: Interacts with STK38 and STK38L. Associates with the SH3 domain of NEDD9. Interacts with VIM and PLXNA3. Interacts with RAB1B, RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); binding to RAB1B is of low affinity compared to other Rab proteins; at least in case of RAB8A and RAB10 can bind 2 molecules of the Rab proteins simultaneously. Interacts with GRAF1/ARHGAP26, GRAF2/ARHGAP10, RAB8A, RAB8B and RAB10; may bind simultaneously to GRAFs and Rabs and connects GRAFs to Rabs (By similarity). Does not interact with RAB1 and RAB11A (By similarity).
messages: Midbody
messages: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export (By similarity).
messages: The C-terminal coiled coil part contains the plexin-interacting region.
messages: The bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to predominantly Rab8, Rab10, Rab13 and Rab15 (in their GTP-bound forms).
messages: The reaction mechanism is subject to discussion. Some work suggest MICAL enzymes directly oxidize actin methionine residues to produce methionine-(R)-S-oxide. Other publications suggest that the enzyme functions as a NADPH oxidase producing H(2)O(2) (EC 1.6.3.1) and that it is the produced H(2)O(2) that is responsible for the methionine-(R)-S-oxide production.
messages: cytoskeleton

10116:Lrtomt
gene id: 10116:Lrtomt
uniprot id: B6CZ62
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function (By similarity). Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (By similarity).
messages: Cytoplasm
messages: Despite its name, the rat TOMT protein does not contain a transmembrane region in contrast to primate orthologs.
messages: Endoplasmic reticulum
messages: Interacts with LHFPL5, PCDH15, TMC1, TMC2 and TMIE. Interacts directly with TMC1. The interaction of TOMT with TMC1 and TMC2 is required for the transportation of TMC1/2 into the stereocilia of hair cells.

10116:Fap
gene id: 10116:Fap
uniprot id: A0A9K3Y732
uniprot id: Q8R492
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

10116:Cited1
gene id: 10116:Cited1
uniprot id: A0A0G2JVK0
uniprot id: F7FI57
uniprot id: Q4V8P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

10116:Csn1s2a
gene id: 10116:Csn1s2a
uniprot id: A6KU19
uniprot id: G3V9R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-casein family.
messages: Important role in the capacity of milk to transport calcium phosphate.
messages: Secreted

10116:Ppp1ca
gene id: 10116:Ppp1ca
uniprot id: A6HYV5
uniprot id: P62138
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Nucleus
messages: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Interacts with PPP1R15A and PPP1R15B; the interactions mediate binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with PPP1R7. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and NCOA5. Interacts with NOM1 and PPP1R8. Interacts with PPP1R16B. Interacts with RPSA only in the presence of PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS and PPP1R8. Interacts with WDR82 in the presence of PPP1R10/PNUTS. Interacts with PPP1R39. Interacts with TRIM28; the interaction dephosphorylates TRIM28 on 'Ser-824' and forms a complex at the p21 promoter site (By similarity). Interacts with PPP1R9A, PPP1R9B and YLPM1. Interacts with NEK2. Interacts with PHACTR4; which acts as an activator of PP1 activity. Interacts with FER; this promotes phosphorylation at Thr-320 (By similarity). Interacts with BTBD10 (By similarity). Interacts with KCTD20 (By similarity). Interacts with FOXP3 (By similarity). Interacts with CENPA (By similarity). Interacts with ATG16L1 (By similarity). Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1 (By similarity). Interacts with tensin TNS1 (By similarity). Interacts with SAXO4, PPP1R21, PPP1R26, PPP1R27, PPP1R35, PPP1R36, PPP1R37, SH3RF2, ELFN1 and ELFN2 (By similarity).
messages: Phosphorylated. Dephosphorylated at Thr-320 in the presence of ionizing radiation (By similarity).
messages: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E (By similarity). Dephosphorylates CENPA (By similarity). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (By similarity).
messages: Widely expressed.
messages: nucleolus
messages: nucleoplasm

10116:Kmt2d
gene id: 10116:Kmt2d
uniprot id: A0A0G2JVD6
uniprot id: A0A8I5ZVL8
names: Subcellular Location Annotation
messages: Nucleus

10116:Mab21l3
gene id: 10116:Mab21l3
uniprot id: A6K3H9
uniprot id: D4AE70
names: Similarity
messages: Belongs to the mab-21 family.

10116:Adam19
gene id: 10116:Adam19
uniprot id: A0A8I5Y236
uniprot id: A6HDQ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Ndc1
gene id: 10116:Ndc1
uniprot id: Q6AXN4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDC1 family.
messages: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane (By similarity).
messages: Interacts with the NUP35/NUP53.
messages: Nucleus membrane
messages: Phosphorylated.
messages: nuclear pore complex

10116:Decr1
gene id: 10116:Decr1
uniprot id: Q64591
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
messages: Homotetramer.
messages: Mitochondrion

10116:Arv1
gene id: 10116:Arv1
uniprot id: A6KJ16
uniprot id: D3ZTJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

10116:Cc2d1b
gene id: 10116:Cc2d1b
uniprot id: Q5FVK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CC2D1 family.
messages: Expressed in epididymal sperm but not in testicular sperm (at protein level).
messages: Nucleus
messages: Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells.

10116:Mep1a
gene id: 10116:Mep1a
uniprot id: Q64230
names: Activity Regulation
names: Cofactor
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Colocalized with E-24.11 in proximal tubules of juxtamedullary nephrons.
messages: Homotetramer consisting of disulfide-linked alpha subunits, homooligomer consisting of disulfide-linked alpha subunit homodimers, or heterotetramer of two alpha and two beta subunits formed by non-covalent association of two disulfide-linked heterodimers (By similarity). Interacts with MBL2 through its carbohydrate moiety. This interaction may inhibit its catalytic activity (By similarity).
messages: Inhibited by actinonin.
messages: Membrane
messages: N-glycosylated; contains GlcNAc, galactose, mannose and a small amount of fucose.

10116:Abcb9
gene id: 10116:Abcb9
uniprot id: A6J117
uniprot id: Q9QYJ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Binds and transports smaller and larger peptides with the same affinity. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
messages: Divided into an N-terminal domain (TMD0) comprising four transmembrane helices and the following core domain (coreABCB9). TMD0 is required for lysosomal localization and LAMP1, LAMP2 and YIF1B interaction. The core domain is required for homodimerization and peptide transport activity.
messages: Found in testis, particularly in the Sertoli cells of the seminiferous tubules. Also expressed in kidney, brain, heart, lung, spleen, thymus, intestine and testis. Higher expression detected in brain and testis than in thymus and intestine.
messages: Homodimer (PubMed:18175933). Interacts (via TMD0 region) with LAMP1; this interaction strongly stabilizes ABCB9 and protects ABCB9 against lysosomal degradation. Interacts (via TMD0 region) with LAMP2 (isoform LAMP-2B). Interacts (via TMD0) with YIF1B; this interaction allows (but is not essential) the ER-to-Golgi trafficking and strongly depends on a salt bridge within TMD0 (By similarity).
messages: Lysosome membrane
messages: Membrane

10116:Or14j5
gene id: 10116:Or14j5
uniprot id: A0A8I5ZRZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Cntn5
gene id: 10116:Cntn5
uniprot id: P97527
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. Contactin family.
messages: Cell membrane
messages: Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system.
messages: Expressed after birth, reaching a maximum at postnatal day 14 in the cerebrum and postnatal day 3 in the cerebellum. Then, it decreases abruptly thereafter (at protein level).
messages: Interacts with PTPRG.
messages: Specifically expressed in the nervous system. Expressed in cerebrum and cerebellum but at low level in spinal chord. In brain, it is expressed in highly restricted regions at postnatal day 7, such as the auditory pathway, including the cochlear nucleus, superior olive, inferior colliculus, medial geniculate nucleus and auditory cortex. Expressed in the accessory olfactory bulb, glomerular and mitral cell layers in the olfactory bulb, anterior thalamic nuclei, layers II-IV of the cerebral cortex, dentate gyrus of the hippocampus and external granule cells and Purkinje cells of the cerebellum. Also expressed in the piriform cortex, inferior olive and facial nucleus. Weakly or not expressed in other parts of the brain.

10116:Nell1
gene id: 10116:Nell1
uniprot id: A0A8I6A059
uniprot id: Q62919
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATRAID; the interaction promotes osteoblast cell differentiation and mineralization (By similarity). Homotrimer. Binds to PKC beta-1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus envelope
messages: Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization (By similarity).
messages: Secreted

10116:Oas1b
gene id: 10116:Oas1b
uniprot id: Q5BKD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the 2-5A synthase family.
messages: Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against viruses via an alternative antiviral pathway independent of RNase L (By similarity).
messages: Endoplasmic reticulum membrane
messages: Highly expressed in the brain, liver, spleen and heart.
messages: Interacts with OSBPL1A and ABCF3.

10116:LOC298111
gene id: 10116:LOC298111
uniprot id: Q8K1Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

10116:Or5be3
gene id: 10116:Or5be3
uniprot id: A6HMY3
uniprot id: D3ZT21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tubb2a
gene id: 10116:Tubb2a
uniprot id: A6J7G7
uniprot id: P85108
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Part of complex consisting of SFPQ, NONO and MATR3. Interacts with AGO1 and AGO2 (By similarity). Part of a complex composed at least of ASH2L, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (By similarity). Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with TFCB.
messages: Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility.
messages: The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

10116:Nup62cl
gene id: 10116:Nup62cl
uniprot id: A0A0G2KB27
uniprot id: A6HLS3
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

10116:Gramd1c
gene id: 10116:Gramd1c
uniprot id: A0A8I6AME7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:Hp1bp3
gene id: 10116:Hp1bp3
uniprot id: Q6P747
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: A central region that included the first H15 (linker histone H1/H5 globular) domain binds at the entry/exit site of the nucleosomal DNA.
messages: Chromosome
messages: Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. May play a role in hypoxia-induced oncogenesis.
messages: Interacts (via PxVxL motif) with CBX5.
messages: Nucleus

10116:Lgals7
gene id: 10116:Lgals7
uniprot id: P97590
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (By similarity).
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: Secreted

10116:Cd3e
gene id: 10116:Cd3e
uniprot id: A6J423
names: Subcellular Location Annotation
messages: Membrane

10116:Or5b21
gene id: 10116:Or5b21
uniprot id: A6I0F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Adgrg7
gene id: 10116:Adgrg7
uniprot id: A6IQP0
uniprot id: D4AAI8
names: Subcellular Location Annotation
messages: Membrane

10116:Slc6a20
gene id: 10116:Slc6a20
uniprot id: Q64093
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A20 subfamily.
messages: Highly expressed in epithelial cells of duodenum, jejunum, ileum, stomach, cecum, colon and kidney proximal tubule. Also expressed in the choroid plexus, microglia and meniges of the brain and in the ovary.
messages: Mediates the Na(+)- and Cl(-)-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids (PubMed:15632147). Also transports glycine, regulates proline and glycine homeostasis in the brain playing a role in the modulation of NMDAR currents (By similarity).

10116:Ccdc8
gene id: 10116:Ccdc8
uniprot id: P62521
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 3M complex, composed of core components CUL7, CCDC8 and OBSL1. Interacts (via PxLPxI/L motif) with ANKRA2 (via ankyrin repeats); may link the 3M complex to histone deacetylases including HDAC4 and HDAC5.
messages: Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome.
messages: Cytoplasm
messages: Despite its name, does not contain a coiled coil domain.
messages: The PxLPxI/L motif mediates interaction with ankyrin repeats of ANKRA2.
messages: centrosome

10116:Ppfia4
gene id: 10116:Ppfia4
uniprot id: Q91Z80
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the liprin family. Liprin-alpha subfamily.
messages: Cell surface
messages: Cytoplasm
messages: Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS. Interacts with RIMS1 and RIMS2 (PubMed:11797009). Interacts with GIT1 and GIT2 (PubMed:12629171). Interacts with GRIP1 (PubMed:11931740). Interacts with KIF1A (PubMed:12522103).
messages: May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity).
messages: The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS (By similarity).

10116:Sema3d
gene id: 10116:Sema3d
uniprot id: F1MAG8
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Prm2
gene id: 10116:Prm2
uniprot id: P11248
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protamine P2 family.
messages: Chromosome
messages: Interacts with TDRP.
messages: Nucleus
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
messages: Proteolytic processing into mature chains is required for histone eviction during spermatogenesis. Transition proteins (TNP1 and TNP2) are required for processing.
messages: Testis.

10116:Kif6
gene id: 10116:Kif6
uniprot id: E9PSL8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

10116:Scarb2
gene id: 10116:Scarb2
uniprot id: A6KK69
uniprot id: P27615
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting.
messages: Acylated by palmitic acid group(s).
messages: Belongs to the CD36 family.
messages: Interacts with GBA1.
messages: Lysosome membrane

10116:Ifrd2
gene id: 10116:Ifrd2
uniprot id: B1WBM5
uniprot id: Q0ZFS6
names: Similarity
messages: Belongs to the IFRD family.

10116:Irx4
gene id: 10116:Irx4
uniprot id: A6JUY4
uniprot id: D3ZRI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

10116:Olr1325
gene id: 10116:Olr1325
uniprot id: A0A8I5ZRD8
uniprot id: A6J3N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Cnp
gene id: 10116:Cnp
uniprot id: A0A097BVJ5
uniprot id: A6HJ42
uniprot id: P13233
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2H phosphoesterase superfamily. CNPase family.
messages: Catalyzes the formation of 2'-nucleotide products from 2',3'-cyclic substrates (By similarity). May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin (By similarity).
messages: Exists as monomers and homodimers.
messages: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
messages: Melanosome
messages: Membrane
messages: Sequencing errors.

10116:Mgme1
gene id: 10116:Mgme1
uniprot id: A6K746
uniprot id: A6K748
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGME1 family.
messages: Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair.
messages: Mitochondrion

10116:Or9i14
gene id: 10116:Or9i14
uniprot id: A6I0G8
uniprot id: D3ZCF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Golm1
gene id: 10116:Golm1
uniprot id: A0A8I5ZPY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

10116:Rbck1
gene id: 10116:Rbck1
uniprot id: A0A0G2K9L6
uniprot id: A6KHM8
uniprot id: Q62921
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Auto-ubiquitinated. Auto-ubiquitination leads to degradation by the proteasome.
messages: Belongs to the RBR family.
messages: Component of the LUBAC complex (linear ubiquitin chain assembly complex) which consists of SHARPIN, RBCK1 and RNF31 (By similarity). LUBAC has a MW of approximately 600 kDa suggesting a heteromultimeric assembly of its subunits (By similarity). Interacts with beta-I-type (PRKCB1) and zeta-type protein kinase C (PRKCZ) (PubMed:9514928). Interacts with UBE2L3 (By similarity). Interacts with IREB2 only in iron-rich conditions (By similarity). Associates with the TNF-R1 signaling complex (TNF-RSC) in a stimulation-dependent manner (By similarity). Interacts with EYA1, TAB2, TAB3, MAP3K7 TRAF6 and RIPK1. Interacts with IRF3 (By similarity).
messages: E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates (By similarity). Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination (By similarity). Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome (PubMed:18303026). Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (By similarity). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (By similarity). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (By similarity). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (By similarity). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (By similarity). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (By similarity). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (By similarity). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (By similarity). Binds polyubiquitin of different linkage types (By similarity).
messages: Phosphorylated. In vitro, phosphorylation inhibits auto-ubiquitination activity.
messages: The RanBP2-type zinc finger, also called Npl4 zinc finger (NZF), mediates binding to 'Met-1'-linked polyubiquitins.
messages: The UBL domain mediates association with RNF31 via interaction with its UBA domain.
messages: Widely expressed.

10116:Or12j4
gene id: 10116:Or12j4
uniprot id: A0A8I6B0Y0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Rspo4
gene id: 10116:Rspo4
uniprot id: D4ACX0
names: Similarity
messages: Belongs to the R-spondin family.

10116:Tmem134
gene id: 10116:Tmem134
uniprot id: A6HYT7
uniprot id: A6HYT8
uniprot id: D3ZF56
uniprot id: D4A3S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Membrane

10116:Dxo
gene id: 10116:Dxo
uniprot id: A6KTK3
uniprot id: Q6MG77
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Preferentially acts on NAD-capped transcripts in response to environmental stress (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation. Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). In contrast to canonical decapping enzymes DCP2 and NUDT16, which cleave the cap within the triphosphate linkage, the decapping activity releases the entire cap structure GpppN and a 5'-end monophosphate RNA. Also has 5'-3' exoribonuclease activities: The 5'-end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (By similarity). Exhibits decapping activity towards FAD-capped RNAs (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity).
messages: Nucleus

10116:Phospho2
gene id: 10116:Phospho2
uniprot id: A6HM16
uniprot id: Q66HC4
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.
messages: Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate.

10116:Impg2
gene id: 10116:Impg2
uniprot id: A6IQP7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: interphotoreceptor matrix

10116:Gjd4
gene id: 10116:Gjd4
uniprot id: A6KPN1
uniprot id: G3V8D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

10116:Tbpl2
gene id: 10116:Tbpl2
uniprot id: A6H909
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBP family.
messages: Cytoplasm
messages: Interacts with TAF3.
messages: Nucleus
messages: Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity).

10116:Pnpt1
gene id: 10116:Pnpt1
uniprot id: A6JQA4
uniprot id: G3V6G7
names: Similarity
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.

10116:Golga5
gene id: 10116:Golga5
uniprot id: Q3ZU82
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Golgi apparatus membrane
messages: Highly phosphorylated during mitosis. Phosphorylation is barely detectable during interphase (By similarity).
messages: Homodimer. Interacts with RAB1A that has been activated by GTP-binding. Interacts with isoform CASP of CUX1.
messages: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.

10116:Serpinb7
gene id: 10116:Serpinb7
uniprot id: A6JSV8
uniprot id: G3V6B5
uniprot id: Q920J5
names: Similarity
messages: Belongs to the serpin family.

10116:Ptprn2
gene id: 10116:Ptprn2
uniprot id: A6KDL9
uniprot id: Q63475
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Has no tyrosine-protein phosphatase activity at mild acidic conditions (pH 5.5). The in vivo relevance of the low PPase activity for the human protein at acidic conditions (pH 4.5) is questioned. This catalytic activity seems to be affected by the replacement of a highly conserved residue in the tyrosine-protein phosphatase domain.
messages: Membrane
messages: Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Required to maintain normal levels of renin expression and renin release. May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (PubMed:20097759). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (By similarity).
messages: Self-associates. Interacts (via cytoplasmic domain) with PTPRN (via cytoplasmic domain). Interacts (precursor form) with CPE. Interacts with HAP1. Interacts with AP2A1 or AP2A2 and AP1G1; indicative for an association with adaptor protein complex 2 (AP-2) and adaptor protein complex 1 (AP-1) (By similarity). Interacts with AP2M1; indicative for an association with adaptor protein complex 2 (AP-2) (PubMed:15882444). Interacts with MYO5A (PubMed:25744490).
messages: Subject to proteolytic cleavage at multiple sites.
messages: The leucine-based sorting signal is proposed to function in trafficking at the plasma membrane.
messages: The tyrosine-based internalization signal is proposed to function at the level of clathrin-mediated endocytosis and recycling.
messages: secretory vesicle membrane
messages: synaptic vesicle membrane

10116:Acp3
gene id: 10116:Acp3
uniprot id: P20646
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.
messages: Belongs to the histidine acid phosphatase family.
messages: Cell membrane
messages: Expressed in prostate epithelium. Also expressed in the pelvic nerve and sacral spinal cord. Localizes in peptidergic and non-peptidergic nociceptive (pain-sensing) neurons.
messages: Homodimer; dimer formation is required for phosphatase activity.
messages: In addition to its tyrosine phosphatase activity, also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP. This extracellular adenosine leads to a decrease in chronic pain by activating A1R in nociceptive neurons.
messages: Inhibited by L(+)-tartrate.
messages: Lysosome membrane
messages: N-glycosylated.
messages: Secreted

10116:Rbl2
gene id: 10116:Rbl2
uniprot id: G3V7P7
uniprot id: O55081
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the retinoblastoma protein (RB) family.
messages: During G0 and early G1 phase of the cell cycle, phosphorylated on Ser-636 and on 5 sites within the domain B. Phosphorylation on Ser-669 in G1 leads to its ubiquitin-dependent proteolysis (By similarity).
messages: Interacts with AATF, KMT5B and KMT5C. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with USP4 (By similarity). Part of the peroxisome proliferator activated receptor alpha (PPAR-alpha) interacting complex (PRIC). Interacts with RINT1 (By similarity). Interacts with PML (By similarity). Interacts with RBBP9 (PubMed:9697699).
messages: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor (By similarity).
messages: Nucleus

10116:Tex261
gene id: 10116:Tex261
uniprot id: A6IAP6
uniprot id: Q5BJW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

10116:Slc10a5
gene id: 10116:Slc10a5
uniprot id: Q4JLT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

10116:Nat1
gene id: 10116:Nat1
uniprot id: P50297
uniprot id: Q45G61
uniprot id: Q45G71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arylamine N-acetyltransferase family.
messages: Cytoplasm
messages: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Acetylates both arylamines and arylalkylamines.

10116:Chst15
gene id: 10116:Chst15
uniprot id: Q8CHI9
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfotransferase 1 family.
messages: Glycosylated.
messages: Golgi apparatus membrane
messages: Homodimer; disulfide-linked (Potential). The relevance of homodimerization is however unsure. May interact with phosphorylated proteins in resting B-cells, including HCK (By similarity).
messages: Inhibited by phenyl beta-GalNAc(4,6-SO(4)).
messages: Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo (By similarity).

10116:Elp6
gene id: 10116:Elp6
uniprot id: B2RYG8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ELP6 family.
messages: Component of the elongator complex which consists of ELP1, ELP2, ELP3, ELP4, ELP5 and ELP6.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in cell migration (By similarity).
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

10116:Pten
gene id: 10116:Pten
uniprot id: O54857
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. Tumor suppressor, the lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (By similarity). Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (By similarity). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (By similarity). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited t…
messages: Belongs to the PTEN phosphatase protein family.
messages: Constitutively phosphorylated by CK2 under normal conditions. Phosphorylation results in an inhibited activity towards PIP3. Phosphorylation can both inhibit or promote PDZ-binding. Phosphorylation at Tyr-336 by FRK/PTK5 protects this protein from ubiquitin-mediated degradation probably by inhibiting its binding to NEDD4 (By similarity). Phosphorylation by PLK3 promotes its stability and prevents its degradation by the proteasome. Phosphorylation by ROCK1 is essential for its stability and activity (By similarity). Phosphorylated on Thr-319 and Thr-321 in the C2-type tensin domain following EGF stimulation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 (By similarity).
messages: Cytoplasm
messages: ISGylated. ISGylation promotes PTEN degradation.
messages: Monomer. The unphosphorylated form interacts with the second PDZ domain of MAGI2 (By similarity). Interacts with MAGI2, MAGI3, MAST1 and MAST3, but neither with MAST4 nor with DLG5; interaction with MAGI2 increases protein stability (By similarity). Interacts with NEDD4 (By similarity). Interacts with NDFIP1 and NDFIP2; in the presence of NEDD4 or ITCH, this interaction promotes PTEN ubiquitination (By similarity). Interacts (via C2 domain) with FRK (By similarity). Interacts with USP7; the interaction is direct (By similarity). Interacts with ROCK1. Interacts with XIAP/BIRC4 (By similarity). Interacts with STK11; the interaction phosphorylates PTEN (By similarity). Interacts with PPP1R16B (By similarity). Interacts with NOP53; regulates PTEN phosphorylation and increases its stability (By similarity). Interacts (via PDZ domain-binding motif) with DLG4; the interaction is induced by NMDA and is required for PTEN location at postsynaptic density (PubMed:20628354). Interacts with the regulatory p85 subunit of the PI3K kinase complex and with Rho GTPase-activating protein DLC1; in resting cells, interacts (via C2 tensin-type domain) with p85 but, following growth factor stimulation, PTEN is phosphorylated which leads to weakened interaction with p85 and enhanced interaction (via C2 tensin-type domain) with DLC1 while p85 interaction with TNS3 increases (By similarity).
messages: Monoubiquitinated; monoubiquitination is increased in presence of retinoic acid. Deubiquitinated by USP7; leading to its nuclear exclusion. Monoubiquitination of one of either Lys-13 and Lys-289 amino acid is sufficient to modulate PTEN compartmentalization (By similarity). Ubiquitinated by XIAP/BIRC4 (By similarity).
messages: Nucleus
messages: PML body
messages: Postsynaptic density
messages: Ubiquitinated by the DCX(DCAF13) E3 ubiquitin ligase complex, leading to its degradation.
messages: dendritic spine
messages: synaptosome

10116:Magi3
gene id: 10116:Magi3
uniprot id: A0A8I6AE46
uniprot id: Q9JK71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Interacts with ADRB1, ADGRB1, LPAR2/EDG4, FZD4, FZD7, GRIN2B, TGFA and VANGL2 (By similarity). Interacts with PTEN. Interacts with ADRB1, PTPRB and unidentified tyrosine phosphorylated proteins. Interacts with DLL1 (By similarity). Interacts with PRRG4 (via cytoplasmic domain) (By similarity).
messages: Membrane
messages: Nucleus
messages: tight junction

10116:Spink1l
gene id: 10116:Spink1l
uniprot id: P09656
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.
messages: Secreted
messages: Seminal vesicle.
messages: Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:3202973, PubMed:2110056). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity).

10116:Sema6a
gene id: 10116:Sema6a
uniprot id: D3ZAX7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Srsf6
gene id: 10116:Srsf6
uniprot id: G3V6S8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the splicing factor SR family.
messages: Binds SREK1/SFRS12 (By similarity). Interacts with DYRK1A.
messages: Detected in liver and brain (at protein level).
messages: Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by DYRK1A, probably in the RS domain. Phosphorylation by DYRK1A modulates alternative splice site selection and inhibits the expression of MAPT/Tau exon 10 (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing (By similarity).

10116:Xbp1
gene id: 10116:Xbp1
uniprot id: Q9R1S4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300; acetylation positively regulates the transcriptional activity of XBP1. Deacetylated by SIRT1; deacetylation negatively regulates the transcriptional activity of XBP1.
messages: Acts as a weak transcriptional factor. Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress. Binds to the ER stress response element (ERSE) upon ER stress. Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences. Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner. Binds to the CDH5/VE-cadherin gene promoter region.
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland. Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes. Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention.
messages: Isoform 1 N-terminus domain is necessary for nuclear localization targeting. Isoform 1 C-terminus domain confers localization to the cytoplasm and is sufficient to impose rapid degradation. Isoform 1 N-terminus and C-terminus regions are necessary for DNA-binding and weak transcriptional activity, respectively.
messages: Isoform 1 interacts with HM13. Isoform 1 interacts with RNF139; the interaction induces ubiquitination and degradation of isoform 1. Isoform 1 interacts (via luminal domain) with DERL1; the interaction obviates the need for ectodomain shedding prior HM13/SPP-mediated XBP1 isoform 1 cleavage. Isoform 1 interacts with HDAC3 and AKT1; the interactions occur in endothelial cell (EC) under disturbed flow. Isoform 1 interacts with the oncoprotein FOS. Interacts with SIRT1.
messages: Isoform 1 is ubiquitinated, leading to proteasome-mediated degradation in response to ER stress.
messages: Membrane
messages: Nucleus
messages: X-box-binding protein 1, cytoplasmic form and luminal form are produced by intramembrane proteolytic cleavage of ER membrane-anchored isoform 1 triggered by HM13/SPP in a DERL1-RNF139-dependent and VCP/p97-independent manner. X-box-binding protein 1, luminal form is ubiquitinated leading to proteasomal degradation.

10116:Amacr
gene id: 10116:Amacr
uniprot id: A6KJS2
uniprot id: G3V8F9
uniprot id: Q5BK88
names: Similarity
messages: Belongs to the CoA-transferase III family.

10116:Pex11a
gene id: 10116:Pex11a
uniprot id: O70597
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peroxin-11 family.
messages: Expressed at high levels in kidney, liver, lung, brain, and testis and at low levels in heart, spleen and skeletal muscle.
messages: Homodimer (By similarity). Heterodimer with PEX11G (By similarity). Probably interacts with COPB2 and COPA (PubMed:9548716). Interacts with PEX19 (By similarity). Interacts with FIS1 (By similarity).
messages: Induced by clofibrate and di(2-ethylhexyl)phtalate (DEHP).
messages: May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane (PubMed:9548716). Promotes membrane protrusion and elongation on the peroxisomal surface.
messages: Peroxisome membrane

10116:C1ql1
gene id: 10116:C1ql1
uniprot id: A6HJN7
uniprot id: D3ZEN8
names: Subcellular Location Annotation
messages: Secreted

10116:B4galt7
gene id: 10116:B4galt7
uniprot id: A0A0G2K4C0
uniprot id: Q4FZU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

10116:Mmp23
gene id: 10116:Mmp23
uniprot id: A6IUR3
uniprot id: O88272
names: Activity Regulation
names: Caution
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M10A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Expressed at the highest levels in ovary and uterus. In ovary expression is strictly confined to granulosa cells of preantral and small antral follicles. Detected also in testis and prostate.
messages: Inhibited by TIMP2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-glycosylated.
messages: Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum.
messages: Proteolytic cleavage might yield an active form.
messages: The ShKT domain associates with, and blocks several potassium channels in the nanomolar to low micromolar range. The relative affinity is Kv1.6 > Kv1.3 > Kv1.1 = Kv3.2 > Kv1.4.

10116:Fmo4
gene id: 10116:Fmo4
uniprot id: Q8K4B6
uniprot id: Q8K4B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FMO family.
messages: Detected in liver and kidney (at protein level).
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.

10116:Gpr20
gene id: 10116:Gpr20
uniprot id: A6HRV8
uniprot id: O35797
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

10116:Tmem14c
gene id: 10116:Tmem14c
uniprot id: B0BNJ9
uniprot id: F7FLK4
uniprot id: Q924P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM14 family.
messages: Mitochondrion membrane
messages: Required for normal heme biosynthesis.

10116:Gatc
gene id: 10116:Gatc
uniprot id: D3ZY68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

10116:Trib3
gene id: 10116:Trib3
uniprot id: Q9WTQ6
names: Caution
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
messages: Detected only in the lung. Not detected in the heart, brain, spleen, liver, skeletal muscle, kidney and testis.
messages: Expression induced during programmed cell death evoked in neuronal cells by NGF-depletion.
messages: Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (By similarity). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (By similarity). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (By similarity). Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation (PubMed:15469416). May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity). Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases (By similarity). Can inhibit APOBEC3A editing of nuclear DNA (By similarity).
messages: Interacts with AKT1, AKT2, MAP2K1 and MAP2K7. Interacts with ATF4 (By similarity). Interacts with DDIT3/CHOP and inhibits its interaction with EP300/P300. Interacts with APOBEC3C (By similarity). Interacts (via N-terminus) with APOBEC3A (By similarity). Interacts with RELA (By similarity).
messages: Nucleus
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: The role of this protein in Akt activation has been demonstrated by Du et al for the mouse ortholog but PubMed:15469416 has not been able to reproduce the result in rat hepatocytes.

10116:Parp10
gene id: 10116:Parp10
uniprot id: A0A8I6AH37
names: Similarity
messages: Belongs to the ARTD/PARP family.

10116:Actg1
gene id: 10116:Actg1
uniprot id: A6HLC1
uniprot id: P63259
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-73 by SETD3.
messages: Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
messages: N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins. In contrast, filament nucleation by the Arp2/3 complex is not affected.
messages: N-terminal cleavage of acetylated methionine of immature cytoplasmic actin by ACTMAP.
messages: Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TWF1, CAPZB, cofilin and profilin.
messages: cytoskeleton

10116:Tspan2
gene id: 10116:Tspan2
uniprot id: A6K3J1
uniprot id: Q9JJW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Expression is restricted to the nervous system.
messages: May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.
messages: Membrane

10116:C2h4orf3
gene id: 10116:C2h4orf3
uniprot id: Q498U0
names: Subcellular Location Annotation
messages: Membrane

10116:Dnai4
gene id: 10116:Dnai4
uniprot id: Q4V8G4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Dynein axonemal particle
messages: Part of the multisubunit axonemal dynein complex formed at least of two heavy chains and a number of intermediate and light chains. Associated with axonemal dynein subunits such as, DNAH2, DNAI3, and DYNLT1. Interacts with DYNLT1.
messages: Plays a critical role in the assembly of axonemal dynein complex, thereby playing a role in ciliary motility.
messages: cilium axoneme
messages: flagellum axoneme

10116:Tmem106a
gene id: 10116:Tmem106a
uniprot id: A0A8L2UL38
uniprot id: A6HJD7
uniprot id: Q5BK83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration (By similarity).
messages: Belongs to the TMEM106 family.
messages: Cell membrane

10116:Neurod4
gene id: 10116:Neurod4
uniprot id: A6K842
names: Subcellular Location Annotation
messages: Nucleus

10116:Spring1
gene id: 10116:Spring1
uniprot id: A6J1L7
uniprot id: D3ZTN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPRING family.
messages: Golgi apparatus membrane
messages: Membrane

10116:Rhot1
gene id: 10116:Rhot1
uniprot id: A0A8I6AVD9
uniprot id: A1L1L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

10116:Or2t1
gene id: 10116:Or2t1
uniprot id: A6K067
uniprot id: G3V6T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Castor1
gene id: 10116:Castor1
uniprot id: A6IKF4
uniprot id: Q5BJZ0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Based on x-ray crystallography data, the protein would be constituted of 4 tandem ACT domains instead of the 2 predicted from the sequence.
messages: Belongs to the GATS family.
messages: Forms homodimers and heterodimers with CASTOR2 (By similarity). Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by arginine (By similarity). Interacts with TM4SF5; the interaction is positively regulated by leucine and is negatively regulated by arginine (By similarity).
messages: Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
messages: Phosphorylation at Ser-14 by AKT1, promoting the interaction between CASTOR1 and RNF167.
messages: Ubiquitinated by RNF167 via 'Lys-29'-polyubiquitination, leading to its degradation, releasing the GATOR2 complex. Ubiquitination by RNF167 is promoted by phosphorylation at Ser-14 by AKT1.
messages: cytosol

10116:Senp7
gene id: 10116:Senp7
uniprot id: A0A8I5ZVM4
uniprot id: A0A8I5ZZN8
uniprot id: D3ZF42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: Cytoplasm
messages: Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms (By similarity).

10116:Cyp2c11
gene id: 10116:Cyp2c11
uniprot id: A0A0G2K879
uniprot id: A6I196
uniprot id: P08683
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and fatty acids. Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes testosterone to 2alpha- and 16alpha-hydroxytestosterone (PubMed:2434473). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFAs) (PubMed:10491410, PubMed:15766564). Converts arachidonic acid (ARA, C20:4(n-6)) primarily to epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, with both R,S and S,R stereochemistry (PubMed:10491410). Preferentially produces 11R,12S-EET enantiomer. To a lesser extent, catalyzes the hydroxylation of arachidonic acid producing hydroxyeicosatetraenoates (HETEs) (PubMed:10491410). Metabolizes eicosapentaenoic acid (EPA, C20:5(n-3)) to epoxyeicosatetraenoic acid (EETeTr) regioisomers, 8,9-, 11,12-, 14,15-, and 17,18-EETeTr, preferentially producing 17R,18S-EETeTr enantiomer (PubMed:15766564). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:2434473, PubMed:15766564).
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Liver and kidney; male-specific.
messages: Microsome membrane

10116:Gapvd1
gene id: 10116:Gapvd1
uniprot id: A0A8I5Y674
uniprot id: A0A8I5ZT12
uniprot id: D4A022
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

10116:Dusp16
gene id: 10116:Dusp16
uniprot id: A6IMD6
uniprot id: D4A3W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

10116:B3galt4
gene id: 10116:B3galt4
uniprot id: A0JN14
uniprot id: Q6MGC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

10116:Yaf2
gene id: 10116:Yaf2
uniprot id: A6K7S8
names: Subcellular Location Annotation
messages: Nucleus

10116:Tnfsf11
gene id: 10116:Tnfsf11
uniprot id: Q9ESE2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation.
messages: Highly expressed in thymus and bone tissues.
messages: Homotrimer. Interacts with TNFRSF11A and TNFRSF11B. Interacts with FBN1 (via N-terminal domain) in a Ca(+2)-dependent manner. Interacts with TNFAIP6 (via both Link and CUB domains).
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.

10116:Guca1a
gene id: 10116:Guca1a
uniprot id: A6JIK4
uniprot id: D3ZII9
names: Similarity
messages: Belongs to the recoverin family.

10116:Fcgr3a
gene id: 10116:Fcgr3a
uniprot id: Q6XPU4
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Forms a heterooligomeric complex with ITAM-containing signaling subunits FCER1G. Interacts (via transmembrane domain) with signaling subunits; this interaction is a prerequisite for receptor complex expression on the cell surface and intracellular signal transduction. Binds the Fc region of antigen-complexed IgG.
messages: N-glycosylated.
messages: Phosphorylated following receptor ligation.
messages: Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Binds with intermediate affinity to both IgG2a and IgG2b. Can bind to IgG2a and IgG2b monomers. Does not display binding to IgG1 or IgG3 (By similarity). Recognizes neutralizing virus-specific IgGs displayed on the cell surface of infected cells and triggers antibody-dependent cellular cytotoxicity (ADCC). Confers protection to lethal influenza virus infection (By similarity). On splenic dendritic cells, uptakes antigen immune complexes and efficiently divert them into MHC class I and II antigen presentation pathways to provide for superior priming of CD4-positive and CD8-positive T cell immune responses (By similarity). Mediates neutrophil activation by IgG complexes redundantly with FCGR2A (By similarity). Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (By similarity). Also acts as a receptor for the Fc region of immunoglobulin epsilon (IgE). Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to IgE allotype a only but not to allotype b. Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes. Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of pro-inflammatory cytokines and the late phase of cutaneous allergic reactions (By similarity). Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821).

10116:Or51b17
gene id: 10116:Or51b17
uniprot id: A6I7C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Gal3st1
gene id: 10116:Gal3st1
uniprot id: A6IKE0
uniprot id: D3ZCT9
uniprot id: Q5PQK7
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

10116:F7
gene id: 10116:F7
uniprot id: Q8K3U6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S1 family.
messages: Can be either O-glucosylated or O-xylosylated at Ser-93 by POGLUT1.
messages: Heterodimer of a light chain and a heavy chain linked by a disulfide bond.
messages: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium (By similarity).
messages: Plasma.
messages: Secreted
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
messages: The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.

10116:Tmlhe
gene id: 10116:Tmlhe
uniprot id: A6KR34
uniprot id: Q91ZW6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gamma-BBH/TMLD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) (PubMed:11431483).
messages: Homodimer.
messages: Mitochondrion matrix

10116:Or4a47
gene id: 10116:Or4a47
uniprot id: A0A8I6A5Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Serp1
gene id: 10116:Serp1
uniprot id: A6JVI6
uniprot id: Q9R2C1
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RAMP4 family.
messages: Detected in astrocytes, brain, lung, liver, kidney, spleen and testis.
messages: Endoplasmic reticulum membrane
messages: Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX.
messages: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins.
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane
messages: Up-regulated in cultured astrocytes in response to hypoxia; levels remain elevated for at least 4 hours after return to normoxia. Up-regulated in ischemic brain.

10116:Xkr9
gene id: 10116:Xkr9
uniprot id: Q5GH54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

10116:Cox11
gene id: 10116:Cox11
uniprot id: A6HI16
uniprot id: D3ZNJ0
names: Function
names: Subcellular Location Annotation
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
messages: Mitochondrion inner membrane

10116:Ism2
gene id: 10116:Ism2
uniprot id: M0RD17
names: Similarity
messages: Belongs to the isthmin family.

10116:Lmbr1l
gene id: 10116:Lmbr1l
uniprot id: A0A0G2JVJ7
uniprot id: Q5FVK3
names: Similarity
messages: Belongs to the LIMR family.

10116:Mtnr1b
gene id: 10116:Mtnr1b
uniprot id: P49287
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in the hippocampus, kidney, and ovary.
messages: High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity.

10116:Olfm3
gene id: 10116:Olfm3
uniprot id: A0A8I5ZW11
uniprot id: A6HV75
uniprot id: A6HV76
uniprot id: P63057
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in the brain (at protein level). Also expressed in the retina, mainly in the ganglion cell layer and in the amacrine cell subregion of the inner nuclear layer. Expressed at high levels in the epithelial cells of the posterior iris and the ciliary body and, at lower levels, in the trabecular meshwork. Isoform 2 preferentially expressed in retina and brain, while isoform 1 preferentially expressed in the tissues of the eye angle.
messages: Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including OLFM3. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (PubMed:22632720). Homodimer. Interacts with MYOC (PubMed:12019210). Interacts with OLFM2 (By similarity).
messages: Secreted
messages: Synapse

10116:Ces2j
gene id: 10116:Ces2j
uniprot id: D3ZP14
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

10116:Ghrh
gene id: 10116:Ghrh
uniprot id: A6JWS0
uniprot id: P09916
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.
messages: Secreted

10116:Or2ab1
gene id: 10116:Or2ab1
uniprot id: A6HEU5
uniprot id: F1LU31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Nos1ap
gene id: 10116:Nos1ap
uniprot id: O54960
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862).
messages: Interacts with the PDZ domain of NOS1 or the second PDZ domain of DLG4 through its C-terminus. Interacts with RASD1 and SYN1, SYN2 and SYN3 via its PID domain. Forms a ternary complex with NOS1 and RASD1. Forms a ternary complex with NOS1 and SYN1.
messages: Mainly expressed in brain. Highly expressed in accessory olfactory bulb, caudate-putamen, cerebellum, cerebral cortex, dentate gyrus of the hippocampus, islands of Calleja, olfactory bulb and supraoptic nucleus. Expressed in kidney glomeruli podocytes (at protein level) (PubMed:33523862).
messages: filopodium
messages: podosome

10116:ST7
gene id: 10116:ST7
uniprot id: A0A0G2JTJ1
uniprot id: A0A0G2KBB5
uniprot id: A6IE32
uniprot id: A6IE33
uniprot id: A6IE34
uniprot id: A6IE35
uniprot id: Q2IBC9
uniprot id: Q2IBD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

10116:Ccng2
gene id: 10116:Ccng2
uniprot id: A6KK49
uniprot id: F7FLZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family.
messages: Nucleus

10116:Dydc1
gene id: 10116:Dydc1
uniprot id: D4A767
names: Similarity
messages: Belongs to the dpy-30 family.

10116:Kcnj6
gene id: 10116:Kcnj6
uniprot id: A0A8I6G5I5
uniprot id: P48550
uniprot id: Q54A91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Associates with GIRK1 or GIRK4 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger (By similarity). Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
messages: Membrane
messages: Pancreatic beta cells and brain.
messages: This potassium channel is controlled by G proteins. It may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium or cesium.

10116:Raet1l
gene id: 10116:Raet1l
uniprot id: Q6AYE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a ligand for KLRK1.
messages: Belongs to the NKG2D ligand family.
messages: Cell membrane
messages: Membrane

10116:Cldn11
gene id: 10116:Cldn11
uniprot id: F7FQF2
uniprot id: Q6IRG7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

10116:Senp17
gene id: 10116:Senp17
uniprot id: Q6IE23
names: Similarity
messages: Belongs to the peptidase C48 family.

10116:Rdh12
gene id: 10116:Rdh12
uniprot id: A6HCH1
uniprot id: D3ZEP9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

10116:Pla2g5
gene id: 10116:Pla2g5
uniprot id: A6ITI7
uniprot id: P51433
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell membrane
messages: Recycling endosome
messages: Secreted
messages: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), preferentially releasing fatty acyl groups with a low degree of unsaturation such as oleoyl (C18:1) and linoleoyl (C18:2) groups (By similarity). Hydrolyzes low-density lipoprotein (LDL) phospholipids releasing unsaturated fatty acids that drive macrophage polarization toward an M2 phenotype (By similarity). May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes at different subcellular locations and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of cardiolipin, a major component of the inner membrane of mitochondria and bacterial membranes. Promotes phagocytosis of bacteria in macrophages through production of lysophosphatidylethanolamines. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (By similarity). Promotes phagocytosis and killing of ingested fungi likely through controlling phagosome-lysosome fusion and phagosome maturation (By similarity). Plays a role in biosynthesis of cysteinyl leukotrienes (CysLTs) in myeloid cells. In eosinophils, triggers perinuclear arachidonate release and LTC4 synthesis in a PLA2G4A-independent way. In neutrophils, amplifies CysLTs biosynthesis initiated by PLA2G4A (By similarity). Promotes immune complex clearance in macrophages via stimulating synthesis of CysLTs, which act through CYSLTR1 to trigger phagocytosis. May regulate antigen processing in antigen-presenting cells. In pulmonary macrophages regulates IL33 production required for activation of group 2 innate lymphoid cells (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysopho…
messages: This enzyme lacks one of the seven disulfide bonds found in similar PA2 proteins.
messages: cis-Golgi network
messages: phagosome
messages: trans-Golgi network

10116:Slc39a7
gene id: 10116:Slc39a7
uniprot id: Q6MGB4
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: In cardiomyocytes, high-glucose exposure up-regulated SLC39A7 expression and induced its phosphorylation.
messages: Rapidly phosphorylated by CK2 following Zn(2+) treatment. This phosphorylation is required for efficient cytosolic Zn(2+) release.
messages: Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels. Acts as gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation on residues, resulting in activation of multiple downstream pathways leading to cell growth and proliferation. Has an essential role in B cell development and is required for proper B cell receptor signaling (By similarity). Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function. Controls cell signaling pathways involved in glucose metabolism in skeletal muscle (By similarity). Has a protective role against ER stress in different biological contexts (PubMed:28232492). Mediates Zn(2+)-induced ferroptosis (By similarity).
messages: cis-Golgi network membrane

10116:Snrnp27
gene id: 10116:Snrnp27
uniprot id: A6IAY9
uniprot id: D3ZR17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

10116:Ripor1
gene id: 10116:Ripor1
uniprot id: A0A8I6B430
uniprot id: A6IYQ8
uniprot id: Q4FZU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RIPOR family.
messages: Cytoplasm
messages: Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration. Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation. Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation.
messages: Golgi apparatus
messages: Interacts (via N-terminus) with RHOA (GTP-bound form); this interaction links active RHOA to STK24 and STK26 kinases. Interacts with RHOB. Interacts with RHOC. Interacts (via C-terminus) with PDCD10; this interaction occurs in a Rho-independent manner. Interacts (via C-terminus) with STK24; this interaction occurs in a PDCD10-dependent and Rho-independent manner. Interacts (via C-terminus) with STK26; this interaction occurs in a PDCD10-dependent and Rho-independent manner. Interacts (via N-terminus) with 14-3-3 proteins; these interactions occur in a Rho-dependent manner.

10116:Nmur1
gene id: 10116:Nmur1
uniprot id: A0A1P0PI13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

10116:Ccl11
gene id: 10116:Ccl11
uniprot id: A6HHD4
uniprot id: P97545
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils (PubMed:9458816). Binds to CCR3 (By similarity).
messages: Secreted

10116:Rdh11
gene id: 10116:Rdh11
uniprot id: Q6AXX5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

10116:Olr1213
gene id: 10116:Olr1213
uniprot id: D4A571
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Kcnk1
gene id: 10116:Kcnk1
uniprot id: A6KJ44
uniprot id: Q9Z2T2
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cell projection
messages: Cytoplasmic vesicle
messages: Detected in brain and in kidney cortex and medulla, especially at the renal brush border membranes of the proximal convoluted tubules, in distal tubules and on intercalated cells of the collecting duct (PubMed:9843722). Detected cerebellum granule neurons (PubMed:25305496). Detected in astrocytes in hippocampus stratum radiatum (PubMed:19571146). Highly expressed in the stria vascularis in the cochlea (PubMed:12855359). Detected in neurons in Scarpa's ganglion in the inner ear, at nerve terminals in the crista ampullaris, in supporting cells and dark cells, but not in hair cells (PubMed:18838117) (at protein level). Detected in the brain cerebellar granule cell layer, amygdala, thalamus reticular nucleus, habenula, mesencephalic trigeminal neurons, neocortex and piriform cortex, and at lower levels in the olfactory bulb (PubMed:11567039). Detected cerebellum granule neurons (PubMed:23169818, PubMed:25305496). Detected in Scarpa's ganglia and crista ampullaris in the inner ear (PubMed:18838117).
messages: Endosome
messages: Homodimer; disulfide-linked (PubMed:9843722). Heterodimer with KCNK2; disulfide-linked (By similarity). In astrocytes, forms mostly heterodimeric potassium channels with KCNK2, with only a minor proportion of functional channels containing homodimeric KCNK1 (By similarity). Interacts with KCNK3 and KCNK9, forming functional heterodimeric channels (By similarity). Interacts with GNG4 (By similarity). Identified in a complex with PSD and ARF6; interacts only with PSD that is bound to ARF6 (By similarity). Interacts with UBE2I (By similarity).
messages: Inhibited by 100 uM quinine. Slightly inhibited by Ba(+) (PubMed:17452494). Activity is first increased and then decreased when the extracellular pH is lowered to 6.0 (PubMed:17452494, PubMed:22948150).
messages: Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:17452494, PubMed:19571146). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium (PubMed:22948150). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel. Channel activity is modulated by activation of serotonin receptors (PubMed:17452494). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity. Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (By similarity). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation. The low channel activity may be due to rapid internalization from the cell m…
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Sumoylation is controversial. Sumoylated by UBE2I. Not sumoylated when expressed in xenopus oocytes or mammalian cells. Sumoylation inactivates the channel, but does not interfere with expression at the cell membrane. Sumoylation of a single subunit is sufficient to silence the dimeric channel. Sumoylation of KCNK1 is sufficient to silence heterodimeric channels formed by KCNK1 and KCNK3 or KCNK9. Desumoylated by SENP1; this activates the channel. Desumoylated by SENP1; this strongly increases halothane-mediated activation of heterodimeric channels formed with KCNK9. SENP1 treatment has no effect.
messages: Synaptic cell membrane
messages: Vesicle
messages: When the external pH is lowered, it takes about 8 minutes till the channel has reached a new, stable state characterized by increased Na(+) permeability. Likewise, when raising the pH back to 7.4, it takes about 12 minutes for the channel to regain its original selectivity for K(+).
messages: dendrite

10116:Sult2a2
gene id: 10116:Sult2a2
uniprot id: P50235
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family.
messages: Cytoplasm
messages: Induced by estrogens and suppressed by androgens. Expression is under the influence of pituitary growth hormone and thyroid hormone.
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze sulfonation of hydroxysteroids and xenobiotics.

10116:Il1a
gene id: 10116:Il1a
uniprot id: P16598
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated within its nuclear localization sequence, which impacts subcellular localization.
messages: Belongs to the IL-1 family.
messages: Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
messages: Cytoplasm
messages: Monomer. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with IL1R1. Interacts with S100A13; this interaction is the first step in the export of IL1A, followed by direct translocation of this complex across the plasma membrane.
messages: Nucleus
messages: Phosphorylated. Phosphorylation greatly enhances susceptibility to digestion and promotes the conversion of pre-IL1A alpha to the biologically active IL1A.
messages: Proteolytic processed by CAPN1 in a calcium-dependent manner. Cleavage from 31 kDa precursor to 18 kDa biologically active molecules.
messages: Secreted
messages: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

10116:Aldh7a1
gene id: 10116:Aldh7a1
uniprot id: A6IX60
uniprot id: Q64057
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in kidney, liver, cochlea and outer hair cells but not inner hair cells or vestibular type I hair cells. Very low levels in lung, brain, intestine and pancreas.
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion
messages: Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.
messages: Nucleus
messages: cytosol

10116:Chrne
gene id: 10116:Chrne
uniprot id: A6HG68
uniprot id: G3V6H4
uniprot id: P09660
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Epsilon/CHRNE sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII (By similarity).
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

10116:Ace2
gene id: 10116:Ace2
uniprot id: C7ECU5
uniprot id: Q5EGZ1
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril, enalaprilat.
messages: Apical cell membrane
messages: Belongs to the peptidase M2 family.
messages: Binds 1 Cl(-) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Cytoplasm
messages: Down-regulated in hypertensive animals. Up-regulated after myocardial infarction.
messages: Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity.
messages: Expressed in heart, kidney and forebrain. In testis, expression is restricted to Leydig cells. In heart, expressed in endothelial cells from small and large arteries, arterial smooth muscle cells, and myocytes (at protein level). Ubiquitously expressed, with highest levels in ileum, bladder and lung.
messages: Glycosylated.
messages: Homodimer. Interacts with the catalytically active form of TMPRSS2 (By similarity). Interacts with SLC6A19; this interaction is essential for expression and function of SLC6A19 in intestine (By similarity). Interacts with ITGA5:ITGB1 (By similarity). Probably interacts (via endocytic sorting signal motif) with AP2M1; the interaction is inhibited by phosphorylation of Tyr-781 (By similarity). Interacts (via PDZ-binding motif) with NHERF1 (via PDZ domains); the interaction may enhance ACE2 membrane residence (By similarity).
messages: In contrast to its human and palm-civet orthologs, does not interact with SARS-CoV spike glycoprotein.
messages: Membrane
messages: Phosphorylated. Phosphorylation at Tyr-781 probably inhibits interaction with AP2M1 and enables interactions with proteins containing SH2 domains.
messages: Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1 (By similarity).
messages: Secreted
messages: The cytoplasmic tail contains several linear motifs such as LIR, PDZ-binding, PTB and endocytic sorting signal motifs that would allow interaction with proteins that mediate endocytic trafficking and autophagy.
messages: cilium

10116:Yod1
gene id: 10116:Yod1
uniprot id: Q32Q05
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation.
messages: Interacts with VCP; the interaction is direct. Interacts with FAF2/UBXD8. Interacts with DERL1; however interaction is dependent on the UBAX-like region, suggesting that it may be indirect. Interacts with PLAA, UBXN6 and VCP; may form a complex involved in macroautophagy.
messages: The C2H2-type zinc finger mediates specificity for 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains but not for 'Lys-11'-linked ubiquitin chains. Selectivity for 'Lys-11'-linked ubiquitin chains is provided by recognition of the sequence surrounding 'Lys-11' in ubiquitin. The S2 site region provides specificity for longer 'Lys-11'-linked ubiquitin chains.
messages: The UBAX-like region mediates the interaction with VCP.

10116:Trpv3
gene id: 10116:Trpv3
uniprot id: E9PU00
names: Subcellular Location Annotation
messages: Membrane

10116:Olr1086
gene id: 10116:Olr1086
uniprot id: A0A8I6GAN4
uniprot id: A6K923
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Asb16
gene id: 10116:Asb16
uniprot id: A6HJH6
uniprot id: D4A8E5
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

10116:Vps13a
gene id: 10116:Vps13a
uniprot id: A0A8I6A4A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS13 family.
messages: Lipid droplet

10116:Vwc2l
gene id: 10116:Vwc2l
uniprot id: A0A8I6AU98
uniprot id: A6KFF7
uniprot id: D4A0X1
names: Subcellular Location Annotation
messages: Synapse

10116:Nnt
gene id: 10116:Nnt
uniprot id: Q5BJZ3
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

10116:Olr1297
gene id: 10116:Olr1297
uniprot id: A0A8I6GGX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Vps36
gene id: 10116:Vps36
uniprot id: B1H248
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

10116:Abhd18
gene id: 10116:Abhd18
uniprot id: Q4V7A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily.
messages: Secreted

10116:Tmem38b
gene id: 10116:Tmem38b
uniprot id: A6KDP9
uniprot id: Q68FV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM38 family.
messages: Endoplasmic reticulum membrane
messages: Homotrimer; trimerization probably requires binding to phosphatidylinositol 4,5-bisphosphate (PIP2).
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

10116:Mob1a
gene id: 10116:Mob1a
uniprot id: Q3T1J9
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity).
messages: Belongs to the MOB1/phocein family.
messages: Binds STK38 and STK38L. Interacts with LATS1 and LATS2 (By similarity). Forms a tripartite complex with STK38 and STK3/MST2 (By similarity).
messages: Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.

10116:Lat2
gene id: 10116:Lat2
uniprot id: Q8CGL2
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2 (By similarity).
messages: Phosphorylated on tyrosines following cross-linking of BCR in B-cells, high affinity IgG receptor (FCGR1) in myeloid cells, or high affinity IgE receptor (FCER1) in mast cells; which induces the recruitment of GRB2.
messages: When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL (By similarity).

10116:Or10g3c
gene id: 10116:Or10g3c
uniprot id: A6KEH6
uniprot id: D3ZJG5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Gtpbp8
gene id: 10116:Gtpbp8
uniprot id: A6IQZ8
uniprot id: Q5BK22
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

10116:Or51k7
gene id: 10116:Or51k7
uniprot id: D3ZCZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Cnn1
gene id: 10116:Cnn1
uniprot id: Q08290
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the calponin family.
messages: Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1.
messages: Smooth muscle, and tissues containing significant amounts of smooth muscle.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

10116:Camta1
gene id: 10116:Camta1
uniprot id: A0A8I6G9L6
names: Similarity
names: Subunit
messages: Belongs to the CAMTA family.
messages: May interact with calmodulin.

10116:Mmgt1
gene id: 10116:Mmgt1
uniprot id: B5DF51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Component of the ER membrane protein complex (EMC).
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (By similarity). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. May be involved in Mg(2+) transport (By similarity).

10116:Gje1
gene id: 10116:Gje1
uniprot id: A6JP74
uniprot id: G3V7K4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Or56b6b
gene id: 10116:Or56b6b
uniprot id: D3ZMC9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Tomm40
gene id: 10116:Tomm40
uniprot id: Q75Q40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom40 family.
messages: Channel-forming protein essential for import of protein precursors into mitochondria (PubMed:10980201, PubMed:15347672, PubMed:19401463). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria (By similarity).
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with mitochondrial targeting sequences (PubMed:10980201, PubMed:15347672). Interacts with TIMM29; linking the TIM22 complex to the TOM complex (By similarity). Forms a complex with BCAP31 (via C-terminus) which mediates the translocation of components of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) from the cytosol to the mitochondria (By similarity). Interacts (via N-terminus) with CYP1A1 (via mitochondrial targeting signal); this interaction is required for CYP1A1 translocation across the mitochondrial outer membrane (PubMed:19401463).
messages: Mitochondrion outer membrane

10116:Ctsql2
gene id: 10116:Ctsql2
uniprot id: A0A9K3Y7W0
uniprot id: Q4QRC2
uniprot id: Q6IE73
names: Similarity
messages: Belongs to the peptidase C1 family.

10116:Vsig1
gene id: 10116:Vsig1
uniprot id: A0A0G2K4G7
uniprot id: A6HLR1
uniprot id: Q4KLY3
names: Subcellular Location Annotation
messages: Membrane

10116:Kcnn2
gene id: 10116:Kcnn2
uniprot id: A0A8L2QBG6
uniprot id: A6IWU8
uniprot id: H6VQ94
uniprot id: P70604
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.
messages: Brain.
messages: Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:8781233, PubMed:20562108). Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization.
messages: Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding.
messages: Inhibited by bee venom neurotoxin apamin (PubMed:8781233, PubMed:20562108). Inhibited by UCL 1684 and tetraethylammonium (TEA) (PubMed:20562108).
messages: Membrane

10116:Ndp
gene id: 10116:Ndp
uniprot id: A6JZW8
uniprot id: D3ZEP2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

10116:Rln3
gene id: 10116:Rln3
uniprot id: A6IYB3
uniprot id: Q8BFS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Highly abundant expression is detected in neurons within the ventomedial dorsal tegmental nucleus and the laterally central gray alpha of the pons. Also detected at much lower levels within the hippocampus.
messages: May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity).
messages: Secreted

10116:Or12e9
gene id: 10116:Or12e9
uniprot id: A6HMZ0
uniprot id: D4A840
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Cpa3
gene id: 10116:Cpa3
uniprot id: A6IHD2
uniprot id: F1M7S4
uniprot id: P21961
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: secretory vesicle

10116:Otop2
gene id: 10116:Otop2
uniprot id: A6HKL7
uniprot id: D3ZCS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

10116:Spdya
gene id: 10116:Spdya
uniprot id: A6HA23
uniprot id: Q8R496
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Speedy/Ringo family.
messages: Interacts with CDK1 (By similarity). Interacts with CDK2. May interact with CDKN1B/KIP1. Identified in a complex with CDK2 and CDKN1B/KIP1, where it interacts primarily with CDK2 (By similarity).
messages: Nucleus
messages: Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2. Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation. Interferes with CDKN1B-mediated inhibition of CDK2. Mediates cell survival during the DNA damage process through activation of CDK2.
messages: The C-terminus is required for CDK2-activation, but not CDK2-binding.

10116:Trub2
gene id: 10116:Trub2
uniprot id: A6JTS1
uniprot id: Q5XFW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pseudouridine synthase TruB family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA.
messages: Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs.
messages: Mitochondrion matrix

10116:Kcnj4
gene id: 10116:Kcnj4
uniprot id: A6HSS0
uniprot id: G3V9M7
uniprot id: P52190
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Detected in kidney distal convoluted tubules (at protein level). Widely expressed throughout the brain. Also found in some peripheral tissues.
messages: Homomultimeric and heteromultimeric association with KCNJ2 and KCNJ12. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking. Interacts with TAX1BP3. TAX1BP3 competes with LIN7 family members for KCNJ4 binding.
messages: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).
messages: Membrane
messages: Postsynaptic cell membrane

10116:Padi3
gene id: 10116:Padi3
uniprot id: P70708
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm
messages: Epidermis and hair follicles.

10116:Mfrp
gene id: 10116:Mfrp
uniprot id: A6J3V6
uniprot id: D3ZU82
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Kcnu1
gene id: 10116:Kcnu1
uniprot id: D4A6Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
messages: Membrane

10116:Ubxn4
gene id: 10116:Ubxn4
uniprot id: Q5HZY0
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.
messages: Endoplasmic reticulum membrane
messages: Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.
messages: Nucleus envelope
messages: The UBX domain is required for interaction with VCP.
messages: The intramembrane domain also contains the signal for ER targeting.

10116:Psen1
gene id: 10116:Psen1
uniprot id: A6JDR2
uniprot id: P97887
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: After endoproteolysis, the C-terminal fragment (CTF) is phosphorylated on serine residues by PKA and/or PKC. Phosphorylation on Ser-347 inhibits endoproteolysis.
messages: Belongs to the peptidase A22A family.
messages: Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (By similarity). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (By similarity). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis. Involved in the regulation of neurite outgrowth (By similarity). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (PubMed:30429473).
messages: Cell membrane
messages: Cytoplasmic granule
messages: Detected in embryonic and adult brain.
messages: Early endosome
messages: Early endosome membrane
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Heterogeneous proteolytic processing generates N-terminal (NTF) and C-terminal (CTF) fragments of approximately 35 and 20 kDa, respectively. During apoptosis, the C-terminal fragment (CTF) is further cleaved by caspase-3 to produce the fragment, PS1-CTF12.
messages: Homodimer.
messages: Homodimer. The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity. Other components which are associated with the complex include SLC25A64, SLC5A7 and PHB. As part of the gamma-secretase complex, interacts with CRB2 (via transmembrane domain) (By similarity). Predominantly heterodimer of a N-terminal (NTF) and a C-terminal (CTF) endoproteolytical fragment. Associates with proteolytic processed C-terminal fragments C83 and C99 of the amyloid precursor protein (APP). Associates with NOTCH1. Associates with cadherin/catenin adhesion complexes through direct binding to CDH1 or CDH2. Interaction with CDH1 stabilizes the complex and stimulates cell-cell aggregation. Interaction with CDH2 is essential for trafficking of CDH2 from the endoplasmic reticulum to the plasma membrane. Interacts with CTNND2, CTNNB1, CTNND1, JUP, HERPUD1, FLNA, FLNB, MTCH1, PKP4 and PARL. Interacts through its N-terminus with GFAP (isoform 2) (By similarity). Interacts with DOCK3 (By similarity). Interacts with UBQLN1 (By similarity).
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Substrates, such as NOTCH1 and APP peptides, are bound between PSEN1 transmembrane domains and via the first lumenal loop and the cytoplasmic loop between the sixth and seventh transmembrane domains. Substrate binding causes a conformation change and formation of an intermolecular antiparallel beta-sheet between PSEN1 and its substrates.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: growth cone
messages: neuron projection

10116:Gart
gene id: 10116:Gart
uniprot id: A6JLG8
uniprot id: G3V918
names: Similarity
messages: In the C-terminal section; belongs to the GART family.
messages: In the N-terminal section; belongs to the GARS family.
messages: In the central section; belongs to the AIR synthase family.

10116:Vopp1
gene id: 10116:Vopp1
uniprot id: B5DEK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VOPP1/ECOP family.
messages: Cytoplasmic vesicle membrane
messages: Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed. May sequester WWOX in lysosomal vesicles and thereby regulate WWOX role as tumor suppressor.
messages: Interacts with WWOX (via WW domain).
messages: Late endosome membrane
messages: Lysosome membrane

10116:Agap3
gene id: 10116:Agap3
uniprot id: A0A0G2K2D4
uniprot id: A0A8I5Y9H3
names: Similarity
messages: Belongs to the centaurin gamma-like family.

10116:Rpl28
gene id: 10116:Rpl28
uniprot id: Q642E2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

10116:Henmt1
gene id: 10116:Henmt1
uniprot id: A6HV35
uniprot id: F1LQ15
uniprot id: Q32PY6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. HEN1 family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.

10116:Aifm1
gene id: 10116:Aifm1
uniprot id: A6JMQ6
uniprot id: Q9JM53
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase family.
messages: Cytoplasm
messages: Functions both as NADH oxidoreductase and as regulator of apoptosis (By similarity). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Binds to DNA in a sequence-independent manner (By similarity). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (By similarity). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (By similarity). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (By similarity).
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: Monomer (oxidized form). Homodimer (reduced form). Upon reduction with NADH, undergoes dimerization and forms tight, long-lived FADH2-NAD charge transfer complexes (CTC) resistant to oxidation. Also dimerizes with isoform 3 preventing its release from mitochondria. Interacts with XIAP/BIRC4. Interacts (via N-terminus) with EIF3G (via C-terminus). Interacts with PRELID1. Interacts with CHCHD4; the interaction increases in presence of NADH. Interacts with processed form of PARP1 (Poly [ADP-ribose] polymerase 1, processed C-terminus); interaction is mediated with poly-ADP-ribose chains attached to PARP1, promoting translocation into the nucleus.
messages: Nucleus
messages: Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation. Ubiquitination at Lys-254 by XIAP/BIRC4 blocks its ability to bind DNA and induce chromatin degradation, thereby inhibiting its ability to induce cell death.
messages: Under normal conditions, a 54-residue N-terminal segment is first proteolytically removed during or just after translocation into the mitochondrial intermembrane space (IMS) by the mitochondrial processing peptidase (MPP) to form the inner-membrane-anchored mature form (AIFmit). During apoptosis, it is further proteolytically processed at amino-acid position 101 leading to the generation of the mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis in a caspase-independent manner.
messages: perinuclear region

10116:Coq6
gene id: 10116:Coq6
uniprot id: Q68FU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the UbiH/COQ6 family.
messages: Cell projection
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with COQ8B and COQ7.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Golgi apparatus
messages: In the kidney, expressed almost exclusively in glomerular podocytes. In the inner ear, expressed in the spiral ganglion, as well as in stria vascularis and spiral ligament cells.
messages: Mitochondrion inner membrane

10116:Or8i2
gene id: 10116:Or8i2
uniprot id: A6HMY2
uniprot id: D3ZTQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Bhlha15
gene id: 10116:Bhlha15
uniprot id: P70562
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in liver, spleen and olfactory epithelium. Weaker expression is seen in skeletal muscle, cardiac muscle, eye and brain tissue.
messages: Forms homodimers or heterodimers with TCF3 gene products E12 and E47. These dimers bind to the E-box site, however, heterodimer with MYOD1 does not bind target DNA.
messages: Lacks a classic transcription activation domain and instead possesses an N-terminal region capable of inhibiting heterologous activators.
messages: Nucleus
messages: Plays a role in controlling the transcriptional activity of MyoD, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).

10116:Elavl2
gene id: 10116:Elavl2
uniprot id: A6JRF7
uniprot id: G3V6U4
names: Similarity
messages: Belongs to the RRM elav family.

10116:Fmo2
gene id: 10116:Fmo2
uniprot id: A6IDA6
uniprot id: G3V6F6
uniprot id: Q6IRI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

10116:Acads
gene id: 10116:Acads
uniprot id: P15651
uniprot id: Q6IMX3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Binds 1 FAD per subunit.
messages: Homotetramer.
messages: Mitochondrion matrix
messages: Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:3968063). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:3968063). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains (PubMed:3968063).

10116:Psmb4
gene id: 10116:Psmb4
uniprot id: A6K2T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

10116:Lgmn
gene id: 10116:Lgmn
uniprot id: A6JEK1
uniprot id: Q9R0J8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by autocatalytic processing at pH 4.
messages: Belongs to the peptidase C13 family.
messages: Detected in kidney cortex (at protein level).
messages: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (By similarity). Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity).
messages: Homodimer before autocatalytic removal of the propeptide. Monomer after autocatalytic processing. May interact with integrins.
messages: In the zymogen form, the uncleaved propeptide blocks access to the active site.
messages: Lysosome

10116:Dlk2
gene id: 10116:Dlk2
uniprot id: A0A8I6AT37
uniprot id: D3ZUK3
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates adipogenesis.

10116:Asmt
gene id: 10116:Asmt
uniprot id: B3GSH5
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
messages: Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
messages: Exhibits very slight night/day variation, if any.
messages: Expressed predominantly in the pineal gland (at protein level). Very low expression, if any, in the retina.
messages: Homodimer.
messages: Pineal melatonin synthesis is severely compromised in most inbred strains. In many inbred strains, genetic defects in ASMT have been identified. Melatonin production may have an impact on gonadal development, testis development being significantly promoted in melatonin-deficient C57BL/6J x Mus musculus molossinus animals.

10116:Gdf9
gene id: 10116:Gdf9
uniprot id: Q9Z0X3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

10116:Gmfg
gene id: 10116:Gmfg
uniprot id: A0A8I6AD83
uniprot id: A6J9J2
uniprot id: A6J9J4
uniprot id: Q80T18
names: Similarity
names: Tissue Specificity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.
messages: Expressed in rat thymus, testis, and spleen. Is present predominantly in proliferative and differentiative organs.

10116:Slc25a28
gene id: 10116:Slc25a28
uniprot id: A6JHD3
uniprot id: G3V865
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

10116:B3gnt9
gene id: 10116:B3gnt9
uniprot id: A0A0G2K1Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

10116:Syt6
gene id: 10116:Syt6
uniprot id: Q62746
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: Cell membrane
messages: Isoform 1: Homodimer; disulfide-linked via the cysteine motif. Isoform 1: Can also form heterodimers with SYT3, SYT7, SYT9 and SYT10. Isoform 1: Interacts with STX1A, STX1B and STX2; the interaction is Ca(2+)-dependent. Isoform 2: Is not able to form homodimer and heterodimers.
messages: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity).
messages: Membrane
messages: The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.
messages: cytosol
messages: synaptic vesicle membrane

10116:Trub1
gene id: 10116:Trub1
uniprot id: A6JI44
uniprot id: Q5M934
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pseudouridine synthase TruB family.
messages: Nucleus
messages: Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs. Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure. Constitutes the major pseudouridine synthase acting on mRNAs. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs. Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity. Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation.
messages: cytosol

10116:Med17
gene id: 10116:Med17
uniprot id: A6JNB4
uniprot id: D4ABU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

10116:Pdlim5
gene id: 10116:Pdlim5
uniprot id: Q62920
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Detected in brain, in neurons, including in hippocampal neurons, and glial cells (at protein level). Detected in heart and skeletal muscle.
messages: In cultured hippocampal neurons, expression levels of both isoform 1 and isoform 2 increases with in vitro development, with prominent expression coinciding with the completion of synaptogenesis and persisting through mature stages.
messages: Interacts with various PKC isoforms through the LIM domains (PubMed:8940095). Interacts with actin and alpha-actinin through the PDZ domain (PubMed:10833443). Interacts (via LIM domains) with SIPA1L1/SPAR; this interaction may occur preferentially with isoform 1 (PubMed:19900557).
messages: May play an important role in the heart development by scaffolding PKC to the Z-disk region (PubMed:8940095, PubMed:20097676). May play a role in the regulation of cardiomyocyte expansion (PubMed:20097676). Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1 (PubMed:20097676). Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons (PubMed:20097676). May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation (PubMed:19900557).
messages: Postsynapse
messages: Postsynaptic density
messages: Presynapse
messages: cytosol

10116:Prkcz
gene id: 10116:Prkcz
uniprot id: A6IUP2
uniprot id: A6IUP4
uniprot id: P09217
names: Activity Regulation
names: Caution
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Atypical PKCs (PRKCI and PRKCZ) exhibit an elevated basal enzymatic activity (that may be due to the interaction with SMG1 or SQSTM1) and are not regulated by diacylglycerol, phosphatidylserine, phorbol esters or calcium ions. Two specific sites, Thr-410 (activation loop of the kinase domain) and Thr-560 (turn motif), need to be phosphorylated for its full activation. Phosphatidylinositol 3,4,5-trisphosphate might be a physiological activator (Probable). Isoform 2: Constitutively active (PubMed:8378304).
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: CDH5 is required for its phosphorylation at Thr-410. Phosphorylated by protein kinase PDPK1; phosphorylation is inhibited by the apoptotic C-terminal cleavage product of PKN2. Phosphorylation at Thr-410 by PI3K activates the kinase (By similarity).
messages: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can r…
messages: Cell junction
messages: Cytoplasm
messages: Endosome
messages: Induced during synaptic long term potentiation.
messages: Interacts with PARD6A, PARD6B and PARD6G. Part of a complex with PARD3, PARD6A or PARD6B or PARD6G and CDC42 or RAC1. Interacts with ADAP1/CENTA1 (By similarity). Forms a ternary complex with SQSTM1 and KCNAB2. Forms another ternary complex with SQSTM1 and GABRR3. Forms a complex with SQSTM1 and MAP2K5. Interacts (via the protein kinase domain) with WWC1. Forms a tripartite complex with WWC1 and DDR1, but predominantly in the absence of collagen. Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with PDPK1 (via N-terminal region). Interacts with WDFY2 (via WD repeats 1-3) (By similarity). Interacts with VAMP2 (By similarity). Forms a complex with WDFY2 and VAMP2 (By similarity). Interacts with APPL1 (By similarity).
messages: Involved in late synaptic long term potentiation phase in CA1 hippocampal cells and long term memory maintenance.
messages: Isoform 1: In brain, expressed in hippocampus, neocortex and cerebellum (at protein level) (PubMed:8378304, PubMed:12857744). Also expressed in lung, liver, kidney, testis and to a lesser extent in pancreas, intestine and skin (at protein level) (PubMed:12857744). Isoform 2: Specifically expressed in brain where it localizes to the hippocampus, neocortex and cerebellum (at protein level) (PubMed:8378304, PubMed:12857744, PubMed:27498875).
messages: Isoform 2 (PKMzeta) was initially thought to be generated by proteolysis of full-length PRKCZ (PubMed:8378304). However, PKMzeta is a bona fide isoform produced by an alternative promoter in intron 4 (PubMed:12857744).
messages: Membrane
messages: Produced by alternative promoter usage.
messages: RNAi-mediated knockdown in the dorsal hippocampus impairs the late phase of long-term potentiation and the establishment of long term memory. Formation of short term memory is not affected.
messages: The C1 domain does not bind the diacylglycerol (DAG).
messages: The PB1 domain mediate mutually exclusive interactions with SQSTM1 and PARD6B.

10116:Ak4
gene id: 10116:Ak4
uniprot id: Q9WUS0
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
messages: Expressed in the central nervous system in a region-specific manner from the middle stage of embryogenesis to the adulthood in the rodent.
messages: Expressed in the pyramidal cells in the hippocampus.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (By similarity). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (By similarity). Also displays broad nucleoside diphosphate kinase activity (By similarity). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (By similarity). Plays a protective role in the cellular response to oxidative stress (By similarity).
messages: Mitochondrion matrix
messages: Monomer (By similarity). Interacts with SLC25A5/ANT2 (By similarity).

10116:Gtpbp1
gene id: 10116:Gtpbp1
uniprot id: D2XV59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.
messages: Cytoplasm
messages: Detected in pineal gland (at protein level).
messages: Interacts with EXOSC2/RRP4, EXOSC3/RRP40, EXOSC5/RRP46, HNRNPD, HNRNPR and SYNCRIP. Identified in a complex with HNRNPD, HNRNPL, HNRNPQ, HNRNPR, HNRNPU and AANAT mRNA, but does not bind mRNA by itself.
messages: Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity.

10116:Leprot
gene id: 10116:Leprot
uniprot id: A6JRN9
uniprot id: Q9JLS8
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Down-regulated by insulin.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with LEPR (By similarity). Interacts with RAB13.
messages: Membrane
messages: Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin (By similarity). Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.

10116:Taf10
gene id: 10116:Taf10
uniprot id: A6I7M8
uniprot id: F7EYT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.

10116:Six4
gene id: 10116:Six4
uniprot id: A0A8I6AM05
uniprot id: A6HC53
uniprot id: D3ZAJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Nucleus

10116:Myh11
gene id: 10116:Myh11
uniprot id: A0A0G2K6S9
uniprot id: E9PTU4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

10116:Rbbp7
gene id: 10116:Rbbp7
uniprot id: A6K2N8
uniprot id: Q71UF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
messages: Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5. The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes. The NuRD complex may interact with MBD3L1. The NuRD complex may interact with MBD3L2. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12. The PRC2/EED-EZH2 complex may also associate with HDAC1. Component of the NURF-1 ISWI chromatin remodeling complex (also called the nucleosome-remodeling factor (NURF) complex) at least composed of SMARCA1, BPTF, RBBP4 and RBBP7. Within the complex interacts with SMARCA1. Component of the BPFT-SMARCA1 complex at least composed of SMARCA1, BPFT, RBBP4 and RBBP7; the complex is catalytically inactive and does not remodel chromatin. Within the complex interacts with SMARCA1. Interacts with BRCA1. Interacts with CDK2AP1 (By similarity). Interacts with CENPA. Interacts with CHD3. Interacts with CHD4. Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP (By similarity). Interacts with HDAC7 (By similarity). Interacts with MTA1 (By similarity). Interacts with PWWP2B (By similarity). Interacts with RB1 (via viral protein-binding dom…
messages: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity).
messages: Nucleus

10116:Or2ak6
gene id: 10116:Or2ak6
uniprot id: M0RB30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Slc16a4
gene id: 10116:Slc16a4
uniprot id: A0A8I6AID2
uniprot id: A6HUT7
uniprot id: Q5U2P9
names: Subcellular Location Annotation
messages: Membrane

10116:Cenpn
gene id: 10116:Cenpn
uniprot id: A0A8L2UQ64
uniprot id: A6IZF9
uniprot id: Q5U2W4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-N/CHL4 family.
messages: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
messages: Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts directly with CENPA. Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1.
messages: Nucleus
messages: centromere
messages: kinetochore

10116:Prkcg
gene id: 10116:Prkcg
uniprot id: A0A8I5ZN16
uniprot id: A6KS41
uniprot id: P63319
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylation on Thr-674 appears to regulate motor functions of junctophilins, JPH3 and JPH4.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-…
messages: Cell membrane
messages: Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-514 (activation loop of the kinase domain), Thr-655 (turn motif) and Thr-674 (hydrophobic region), need to be phosphorylated for its full activation.
messages: Cytoplasm
messages: Interacts with GRIA4. Interacts with CDCP1, TP53INP1 and p53/TP53 (By similarity). Interacts with BMAL1 (By similarity).
messages: Membrane
messages: Ubiquitinated.
messages: dendrite
messages: perinuclear region
messages: synaptosome

10116:Rgs14
gene id: 10116:Rgs14
uniprot id: A6KAT5
uniprot id: O08773
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in neurons of the V2 secondary visual cortex area (at protein level). Expressed at high levels in the brain cortex, hippocampus, striatum, thalamus and substantia nigra, in the lung, and spleen. Low expression has been found in heart, liver, skeletal muscle and testis.
messages: Interacts with GNAI1, GNAI2 and GNAI3 (PubMed:11387333, PubMed:16870394, PubMed:17603074, PubMed:21158412, PubMed:11976690). Interacts with GNAO1 (By similarity). Interacts (via RGS and GoLoco domains) with GNAI1; the interaction occurs in the centrosomes. Interaction with GNAI1 or GNAI3 (via active GTP- or inactive GDP-bound forms) prevents association of RGS14 with centrosomes or nuclear localization. Interacts with RABGEF1; the interactions is GTP-dependent. Interacts with RAP2A; the interactions is GTP-dependent and does not alter its function on G(i) alpha subunits either as GAP or as GDI. Associates with microtubules (By similarity). Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14 (PubMed:19319189). Interacts with RIC8A (via C-terminus) (PubMed:21158412). Interacts (via RBD 1 domain) with HRAS (active GTP-bound form preferentially). Interacts (via RBD domains) with BRAF (via N-terminus); the interaction mediates the formation of a ternary complex with RAF1. Interacts (via RBD domains) with RAF1 (via N-terminus); the interaction mediates the formation of a ternary complex with BRAF (PubMed:19878719). Interacts with KRAS (active GTP-bound form preferentially), MRAS (active GTP-bound form preferentially), NRAS (active GTP-bound form preferentially) and RRAS (active GTP-bound form preferentially) (PubMed:19319189).
messages: Membrane
messages: Nucleus
messages: PML body
messages: Phosphorylated by PKC. Phosphorylation is increased in presence of forskolin and may enhance the GDI activity on G(i) alpha subunit GNAI1.
messages: Postsynaptic density
messages: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI) (PubMed:11976690). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division; required for completion of the first mitotic division of the embryo. Involved in visual memory processing capacity; when overexpressed in the V2 secondary visual cortex area. Involved in hippocampal-based learning and memory; acts as a suppressor of synaptic plasticity in CA2 neurons. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance.
messages: The GoLoco domain is necessary for GDP-dissociation inhibitor (GDI) activity, translocation out of the nucleus and interaction with G(i) alpha subunits GNAI1, GNAI2 and GNAI3.
messages: The RBD domains are necessary for localization to the nucleus and centrosomes.
messages: The RGS domain is necessary for GTPase-activating protein (GAP) activity for G subunits and localization to the nucleus and centrosomes.
messages: centrosome
messages: dendrite
messages: dendritic spine
messages: spindle
messages: spindle pole

10116:Prl3a1
gene id: 10116:Prl3a1
uniprot id: A0A0M6L0N5
uniprot id: Q8K3W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

10116:Maml3
gene id: 10116:Maml3
uniprot id: A0A8I6ABZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

10116:Fat1
gene id: 10116:Fat1
uniprot id: A0A0G2K5L1
uniprot id: Q9WU10
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:St3gal6
gene id: 10116:St3gal6
uniprot id: F7F9B2
uniprot id: Q569D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

10116:Nqo1
gene id: 10116:Nqo1
uniprot id: A6IZ00
uniprot id: P05982
names: Caution
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.
messages: By polycyclic hydrocarbons (Governed by the aromatic hydrocarbon-responsive (AH) locus).
messages: Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (PubMed:8999809, PubMed:1703398, PubMed:7862630). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (By similarity). Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (By similarity). Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (By similarity).
messages: Homodimer (PubMed:7568029). Interacts with PDLIM4 isoform 2; this interaction stabilizes PDLIM4 isoform 2 in response to oxidative stress and protects it from ubiquitin-independent degradation by the core 20S proteasome (By similarity). Interacts with TP73 (via SAM domain); this interaction is NADH-dependent, stabilizes TP73 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome (By similarity). Interacts with TP53; this interaction is NADH-dependent, stabilizes TP53 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome (By similarity).
messages: PubMed:2480957 sequence seems incorrectly to be attributed to a mouse sequence while it really seems to correspond to the rat sequence.
messages: Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency.
messages: This protein is inhibited by dicoumarol.
messages: cytosol

10116:Asgr1
gene id: 10116:Asgr1
uniprot id: P02706
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Calcium is required for ligand binding.
messages: Expressed exclusively in hepatic parenchymal cells.
messages: Interacts with LASS2.
messages: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
messages: Membrane
messages: Phosphorylated on a cytoplasmic Ser residue.
messages: Two types of rat hepatic lectin have been identified, RHL-1 and RHL-2/3, having a relative abundance of 4:1.

10116:Olr921
gene id: 10116:Olr921
uniprot id: D3ZC13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ptbp1
gene id: 10116:Ptbp1
uniprot id: A6K8W5
uniprot id: Q00438
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Monomer. Part of a ternary complex containing KHSRP, PTBP1, PTBP2 and HNRPH1. Interacts with RAVER1 and SFPQ (By similarity).
messages: Nucleus
messages: Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform.

10116:Hbegf
gene id: 10116:Hbegf
uniprot id: Q06175
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).
messages: Interacts with FBLN1. Interacts with EGFR and ERBB4 (By similarity).
messages: Most abundant in skeletal muscle, lung, spleen brain and heart.
messages: O-glycosylated.
messages: extracellular space

10116:Khdrbs2
gene id: 10116:Khdrbs2
uniprot id: A6IN86
uniprot id: Q920F3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the KHDRBS family.
messages: Expressed in the cortex, cerebellum, striatum, midbrain, brainstem and thalamus of the brain (at protein level). Expressed in neurons (at protein level). Expressed in brain and testis. Expressed in the dentate gyrus of the hippocampus.
messages: Methylated.
messages: Nucleus
messages: Phosphorylated on tyrosine residues by FYN. Tyrosine phosphorylated by PTK6 and SRC (By similarity). Tyrosine phosphorylated by SRC during mitosis (By similarity).
messages: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis (By similarity). Binds both poly(A) and poly(U) homopolymers (By similarity). Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity).
messages: Self-associates to form homooligomers. Interacts with SAFB, SFRS9 and YTHDC1. Found in a complex with KHDRBS1, KHDRBS2 and KHDRBS3. Interacts with RBMX (By similarity). Interacts with the SH3 domains of FYN and PLCG1 (By similarity). Interacts with the SH2 domains of FYN, GRAP2, PLCG1 and RASA1 (By similarity). Interacts with RBMX.

10116:Pdpr
gene id: 10116:Pdpr
uniprot id: A6IZ83
names: Similarity
messages: Belongs to the GcvT family.

10116:Or5al1
gene id: 10116:Or5al1
uniprot id: D3ZLQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Thoc5
gene id: 10116:Thoc5
uniprot id: Q68FX7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes (By similarity).
messages: Belongs to the THOC5 family.
messages: Cytoplasm
messages: Interacts with phosphorylated CSF1R. Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, ALYREF/THOC4, and THOC7. Interacts (via N-terminus) with the NTF2 domain of NXF1. Forms a complex with CEBPB. Interacts with CPSF6; indicative for an association with the cleavage factor Im (CFIm) complex. Interacts with LUZP4. Interacts with NCBP3 (By similarity).
messages: Nucleus
messages: Phosphorylated on tyrosine upon binding to activated CSF1R; which causes a dissociation of the two proteins. Phosphorylation on Ser-5 and/or Ser-6 is required for nuclear export. Phosphorylated on Thr-327 in insulin-stimulated adipocytes (By similarity).
messages: Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development (By similarity).

10116:Or5p73
gene id: 10116:Or5p73
uniprot id: A0A8I5ZNI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Klhdc3
gene id: 10116:Klhdc3
uniprot id: Q6AYI2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter KLHDC3.
messages: Cytoplasm
messages: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons. The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine. May be involved in meiotic recombination process.

10116:Arc
gene id: 10116:Arc
uniprot id: Q63053
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Arc expression is regulated at transcription, post-transcription and translation levels (PubMed:9808461, PubMed:10570490, PubMed:11226315, PubMed:18614031). Transcription is tightly coupled to encoding of information in neuronal circuits (PubMed:10570490). Expression is induced by neuronal and synaptic activity (PubMed:7777577, PubMed:7857651, PubMed:10570490). Induced at highest level in hippocampus within 30 minutes, dropping to basal levels within 24 hours (PubMed:7777577, PubMed:7857651). Arc transcripts are transported to dendrites and become enriched at sites of local synaptic activity where they are locally translated into protein (PubMed:9808461, PubMed:18614031). Arc transcripts resemble some viral RNAs and contain an internal ribosomal entry site (IRES) that allows cap-independent translation (PubMed:11226315).
messages: Belongs to the ARC/ARG3.1 family.
messages: Early endosome membrane
messages: Expressed during postnatal development from day 8 (PubMed:7857651). Highest expression around day 23 with moderate levels expressed to adulthood (PubMed:7857651).
messages: Expressed exclusively in certain parts of the brain including cortex and molecular layer of the hippocampus. Typically expressed at high level in a minority of neurons. Basal expression higher in cortex than in hippocampus, highest in visual cortex.
messages: Extracellular vesicle membrane
messages: Homooligomer; homooligomerizes into virion-like capsids (PubMed:29328916, PubMed:30028513, PubMed:31080121). Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2 (PubMed:17088211). Interacts with CAMK2B (in the kinase inactive state); leading to target ARC to inactive synapses (PubMed:22579289). Interacts with PSEN1 (By similarity). Interacts with GRIN2A and GRIN2B; inhibiting homooligomerization (PubMed:31080121).
messages: Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system (PubMed:29328916). ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation (PubMed:29328916). ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons (PubMed:29328916). Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory (PubMed:10818134, PubMed:17088211, PubMed:17088212, PubMed:17088213). Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis (PubMed:17088211, PubMed:17088212). Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses (PubMed:23791196). Accumulates at weaker synapses, probably to prevent their undesired enhancement (PubMed:22579289). This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material (PubMed:29328916). Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (PubMed:10818134). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (By similarity). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation (By similarity).
messages: Palmitoylation anchors the protein into the membrane by allowing direct insertion into the hydrophobic core of the lipid bilayer.
messages: Phosphorylation at Ser-260 by CaMK2 prevents homooligomerization into virion-like capsids by disrupting an interaction surface essential for high-order oligomerization. Phosphorylation by CaMK2 inhibits synaptic activity.
messages: Postsynaptic cell membrane
messages: Postsynaptic density
messages: Synapse
messages: The protein is evolutionarily related to retrotransposon Gag proteins: it contains large N- and C-terminal domains that form a bi-lobar architecture similar to the capsid domain of human immunodeficiency virus (HIV) gag protein (PubMed:29328916, PubMed:25864631). It contains structural elements found within viral Gag polyproteins originated from the Ty3/gypsy retrotransposon family and retains the ability to form virion-like capsid structures that can mediate mRNA transfer between cells (PubMed:29328916). Tetrapod and fly Arc protein-coding genes originated independently from distinct lineages of Ty3/gypsy retrotransposons (PubMed:29328916).
messages: Transcripts enriched in dendrites may be translated locally.
messages: Ubiquitinated by UBE3A, leading to its degradation by the proteasome, thereby promoting AMPA receptors (AMPARs) expression at synapses. Ubiquitinated by RNF216 at Lys-268 and Lys-269 limiting ARC protein levels induced by synaptic activity and thus regulating ARC-dependent forms of synaptic plasticity.
messages: acrosome
messages: cell cortex
messages: clathrin-coated vesicle membrane
messages: cytoskeleton
messages: dendrite
messages: dendritic spine

10116:Drd3
gene id: 10116:Drd3
uniprot id: A6IR24
uniprot id: P19020
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation (By similarity).
messages: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
messages: Interacts with CLIC6 (PubMed:14499480). Interacts with GRK4. Interacts with PALM. Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity).
messages: Mainly in limbic areas of brain.
messages: Membrane
messages: Palmitoylated.
messages: Phosphorylated by GRK4.

10116:Parpbp
gene id: 10116:Parpbp
uniprot id: A0A0H2UHD2
uniprot id: A6IFN1
uniprot id: Q9EQ10
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Interacts with RAD51 and PCNA. Interacts with PARP1 (By similarity). Interacts with TASOR (By similarity).
messages: Nucleus
messages: Present in testis (at protein level). Expressed in testis, gastrointestinal tract (jejunum, ileum, and colon) and immune system (thymus and spleen). Weakly expressed in lung, kidney, pituitary gland and muscle.
messages: Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect (By similarity). Binds single-strand DNA and poly(A) homopolymers.
messages: The gene encoding Arom is located in the opposite strand of the gene encoding MCH.

10116:Nit2
gene id: 10116:Nit2
uniprot id: A6IQN1
uniprot id: Q497B0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
messages: Cytoplasm
messages: Has omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively.
messages: Homodimer.

10116:Abl1
gene id: 10116:Abl1
uniprot id: E9PT20
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

10116:Styxl2
gene id: 10116:Styxl2
uniprot id: D3ZRM0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

10116:Wars2
gene id: 10116:Wars2
uniprot id: A0A8I6ANK9
uniprot id: F1M8H2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

10116:Slc41a1
gene id: 10116:Slc41a1
uniprot id: A6IC32
uniprot id: D3ZM22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

10116:Tmem50a
gene id: 10116:Tmem50a
uniprot id: B1WBU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

10116:Phf23
gene id: 10116:Phf23
uniprot id: Q6AY75
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria.
messages: Belongs to the PHF23 family.
messages: Cytoplasm
messages: Interacts with LRSAM1.
messages: Nucleus
messages: The PHD-type zinc-finger domain is required for interaction with LRSAM1 and negative regulation of autophagy.

10116:LOC291863
gene id: 10116:LOC291863
uniprot id: A0A9K3Y765
uniprot id: Q68G49
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

10116:Jph2
gene id: 10116:Jph2
uniprot id: A6JX22
uniprot id: Q2PS20
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Interacts with TRPC3 (By similarity). Interacts with BAG5 and HSPA8; the interaction with HSPA8 is increased in the presence of BAG5 (By similarity). Junctophilin-2 N-terminal fragment: Interacts with MEF2C (By similarity).
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane
messages: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes. Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads. Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions.
messages: Nucleus
messages: Phosphorylation on Ser-165, probably by PKC, affects RYR1-mediated calcium ion release, interaction with TRPC3, and skeletal muscle myotubule development.
messages: Proteolytically cleaved by calpain in response to cardiac stress. The major cleavage site takes place at the C-terminus and leads to the release of the Junctophilin-2 N-terminal fragment chain (JP2NT).
messages: Sarcoplasmic reticulum membrane
messages: The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, by interacting with phospholipids. Has affinity for phosphatidylserine, and phosphorylated phosphatidylinositols including PtdIns3P, PtdIns4P, PtdIns5P, PtdIns(3,5)P2 and PtdIns(3,4,5)P3.
messages: The bipartite nuclear localization signal (bNLS) and Ala-rich (alanine-rich; ARR) regions are involved in DNA-binding.
messages: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins.

10116:Olr1132
gene id: 10116:Olr1132
uniprot id: D3ZMP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:P2ry12
gene id: 10116:P2ry12
uniprot id: A6JVK4
uniprot id: Q9EPX4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Required for normal platelet aggregation and blood coagulation.
messages: The transmembrane domain is composed of seven transmembrane helices; most of these are not strictly perpendicular to the plane of the membrane, but are tilted and/or kinked. Agonist binding promotes a conformation change in the extracellular loops that leads to an inward movement of the transmembrane helices. Antagonists can bind to an overlapping site, but block the inward movement of the transmembrane helices (By similarity).

10116:Trpc4
gene id: 10116:Trpc4
uniprot id: A6JVB2
uniprot id: F7F3R3
uniprot id: F7FEC4
uniprot id: Q91ZM1
names: Subcellular Location Annotation
messages: Membrane

10116:Sstr3
gene id: 10116:Sstr3
uniprot id: A6HSL2
uniprot id: P30936
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Densely expressed in cerebellum and at moderate levels in the amygdala, cortex, striatum, spleen, liver and pituitary.
messages: Homodimer and heterodimer with SSTR2. Heterodimerization with SSTR2 inactivates SSTR3 receptor function.
messages: Membrane
messages: Phosphorylated. Phosphorylation increases upon somatostatin binding.
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.

10116:Fam166c
gene id: 10116:Fam166c
uniprot id: A6HAD4
uniprot id: D3ZW52
names: Similarity
messages: Belongs to the CIMIP2 family.

10116:Bsg
gene id: 10116:Bsg
uniprot id: P26453
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: By activation of lymphocytes by mitogens. By estrogen in the uterine epithelium of ovariectomized animals.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (By similarity). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (By similarity).
messages: Expressed in the skeletal muscle, liver, small intestine, kidney, testis, brain, heart and spleen (PubMed:8425897). Also present in various immature cells and endothelia (PubMed:2009910).
messages: Homooligomer (By similarity). Interacts with NXNL1, SLC2A1 and SLC16A1/GLUT1 (By similarity). Interacts with XKR8; promoting its localization at the cell membrane (By similarity).
messages: Homooligomer (Probable). Interacts with SLC16A1; interaction mediates SLC16A1 targeting to the plasma membrane (PubMed:10921872). Interacts with SLC16A3; interaction mediates SLC16A3 targeting to the plasma membrane (PubMed:11719518). Interacts with VEGFA, KDR/VEGFR2, PPIA/CYPA, SLC16A12, SLC16A11, ATP1B2, MAG, L1CAM and AJAP1 (By similarity). Interacts with PPIL2; regulates BSG transport to the cell membrane (By similarity).
messages: In uterus during peri-implantation period strongly expressed in the luminal epithelium on day 1 of pregnancy and gradually decreased to a basal concentration from day 3 to day 5 of pregnancy. Strongly expressed in the implanting blastocyst and primary decidua on day 6 of pregnancy.
messages: Interacts with SLC16A6; this interaction mediates targeting to the plasma membrane.
messages: Photoreceptor inner segment
messages: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (By similarity). Plays an important role in targeting the monocarboxylate transporters SLC16A1/GLUT1 and SLC16A3 to the plasma membrane (PubMed:10921872). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (By similarity). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells (By similarity). Plays an important role in spermatogenesis; mediates interactions between germ cells and Sertoli cell and is essential for the development/differentiation of germ cells to round spermatids (By similarity).
messages: photoreceptor outer segment

10116:Atl3
gene id: 10116:Atl3
uniprot id: A0A8I6AEN1
uniprot id: Q0ZHH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
messages: Endoplasmic reticulum membrane
messages: GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (By similarity).
messages: Interacts with ZFYVE27 (By similarity). Interacts with REEP5 (By similarity).

10116:Fam228a
gene id: 10116:Fam228a
uniprot id: Q5XIN5
names: Similarity
messages: Belongs to the FAM228 family.

10116:Ppil3
gene id: 10116:Ppil3
uniprot id: A6IP66
uniprot id: Q812D3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cyclophilin-type PPIase family.
messages: Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.
messages: Identified in the spliceosome C complex.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing (By similarity).

10116:Akr1b10
gene id: 10116:Akr1b10
uniprot id: M0R8B8
uniprot id: Q6AY99
names: Similarity
messages: Belongs to the aldo/keto reductase family.

10116:Fbxo6
gene id: 10116:Fbxo6
uniprot id: Q923V4
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Abundantly expressed in 14.5-day fetal liver. Expression decreases during late liver development and stays at low levels until birth. Expression increases 24 hours after birth and reaches highest levels in adult liver.
messages: Cytoplasm
messages: Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with VCP, CHEK1 and CUL1 (By similarity).
messages: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to ensure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity).

10116:Cited4
gene id: 10116:Cited4
uniprot id: A6IRZ0
uniprot id: Q99MA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells (By similarity).
messages: Belongs to the CITED family.
messages: Cytoplasm
messages: Interacts via its C-terminal region with the CH1 domain of CREBBP and EP300. Interacts with all TFAP2/AP-2 isoforms (By similarity).
messages: Nucleus

10116:Slc6a8
gene id: 10116:Slc6a8
uniprot id: A0A8I5ZS61
uniprot id: B4F7D9
uniprot id: P28570
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily.
messages: Cell membrane
messages: Creatine:sodium symporter which mediates the uptake of creatine (PubMed:12433955, PubMed:8297374, PubMed:15702372, PubMed:32115505). Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity).
messages: Expressed in the small intestine (at protein level) (PubMed:12433955, PubMed:15702372). Expressed in the brain, heart, skeletal muscle and kidney (PubMed:8297374). Expressed in the leukocytes (PubMed:32115505).
messages: Glycosylated.
messages: Membrane
messages: Was originally thought to be a choline transporter.

10116:Nipa2
gene id: 10116:Nipa2
uniprot id: A6KD29
uniprot id: D3ZUV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

10116:Or1j14
gene id: 10116:Or1j14
uniprot id: A0A8I5ZQ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Hbe2
gene id: 10116:Hbe2
uniprot id: O88753
names: Similarity
messages: Belongs to the globin family.

10116:Or52z14
gene id: 10116:Or52z14
uniprot id: A0A8I5ZXV7
uniprot id: A6I7A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Sstr5
gene id: 10116:Sstr5
uniprot id: A6HD30
uniprot id: G3V8G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

10116:Spem1
gene id: 10116:Spem1
uniprot id: A6HFU1
uniprot id: D3ZZ79
names: Subcellular Location Annotation
messages: Membrane

10116:Psma7
gene id: 10116:Psma7
uniprot id: A6KMC7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

10116:Cth
gene id: 10116:Cth
uniprot id: P18757
uniprot id: Q9EQS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family.
messages: Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate (Probable) (PubMed:13525371). Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione. Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce hydrogen sulfide (H2S). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, and two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia. Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (By similarity). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate (PubMed:13525371). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (Probable).
messages: Cytoplasm
messages: Homotetramer (By similarity). Interacts with CALM in a calcium-dependent manner (By similarity).

10116:Hoxa2
gene id: 10116:Hoxa2
uniprot id: A6K0Q2
uniprot id: G3V6R6
uniprot id: P31246
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Proboscipedia subfamily.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

10116:Dlx1
gene id: 10116:Dlx1
uniprot id: A6HM52
uniprot id: G3V669
names: Subcellular Location Annotation
messages: Nucleus

10116:Armcx3
gene id: 10116:Armcx3
uniprot id: Q5XID7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Cytoplasm
messages: Interacts (via ARM domain) with MIRO1, MIRO2 and TRAK2. The interaction with Miro is calcium-dependent. Interacts with Sox10.
messages: Mitochondrion outer membrane
messages: Nucleus
messages: Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the Trak2-kinesin motor complex via its interaction with Miro and Trak2. Mitochondrial distribution and dynamics is regulated through Armcx3 protein degradation, which is promoted by PCK and negatively regulated by Wnt1. Enhances the Sox10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters.

10116:Pacs1
gene id: 10116:Pacs1
uniprot id: A6HZ35
uniprot id: O88588
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with AP-1 and AP-3 but not with AP-2 complexes (By similarity). Interacts with FURIN (By similarity). Forms a ternary complex with furin and AP-1 (PubMed:9695949). Interacts with PKD2 (via acidic region) (By similarity). Interacts with SORL1 (By similarity). Interacts with WDR37 (By similarity).
messages: Belongs to the PACS family.
messages: Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity).
messages: trans-Golgi network

10116:Cox4i2
gene id: 10116:Cox4i2
uniprot id: A0A8I5ZVG3
uniprot id: A6KHQ9
uniprot id: Q91Y94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Highly expressed in lung.
messages: Membrane
messages: Mitochondrion inner membrane

10116:Fgl1
gene id: 10116:Fgl1
uniprot id: Q5M8C6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Interacts (via the Fibrinogen C-terminal domain) with LAG3 (via Ig-like domains 1 and 2).
messages: Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes.
messages: Secreted

10116:St6galnac2
gene id: 10116:St6galnac2
uniprot id: F7FDY5
uniprot id: Q6ZYN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

10116:Senp1
gene id: 10116:Senp1
uniprot id: A0A0G2JVG1
uniprot id: A0A0G2K1R8
names: Similarity
messages: Belongs to the peptidase C48 family.

10116:Chrna6
gene id: 10116:Chrna6
uniprot id: P43143
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-6/CHRNA6 sub-subfamily.
messages: Cell membrane
messages: Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Interacts with LYPD6.
messages: Postsynaptic cell membrane

10116:Tfcp2
gene id: 10116:Tfcp2
uniprot id: A0A0G2JTJ9
uniprot id: A6KCK2
uniprot id: G3V969
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

10116:Hnrnpf
gene id: 10116:Hnrnpf
uniprot id: A6IL49
uniprot id: Q794E4
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity).
messages: Detected in liver, thymus, spleen and testis.
messages: Identified in the spliceosome C complex. Interacts with AGO1, AGO2, TBP and TXNL4/DIM1 (By similarity).
messages: Sumoylated.
messages: The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA.
messages: nucleoplasm

10116:Sptssb
gene id: 10116:Sptssb
uniprot id: A6J5N9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:Lars1
gene id: 10116:Lars1
uniprot id: Q5PPJ6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

10116:Bmal1
gene id: 10116:Bmal1
uniprot id: Q9EPW1
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-538 by CLOCK during the repression phase of the circadian cycle. Acetylation facilitates recruitment of CRY1 protein and initiates the repression phase of the circadian cycle. Acetylated at Lys-538 by KAT5 during the activation phase of the cycle, leading to recruitment of the positive transcription elongation factor b (P-TEFb) and BRD4, followed by productive elongation of circadian transcripts. Deacetylated by SIRT1, which may result in decreased protein stability.
messages: Component of the circadian clock oscillator which includes the CRY1/2 proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER1/2/3 proteins (By similarity). Forms a heterodimer with CLOCK (By similarity). The CLOCK-BMAL1 heterodimer is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and BMAL1 (By similarity). Part of a nuclear complex which also includes RACK1 and PRKCA; RACK1 and PRKCA are recruited to the complex in a circadian manner (By similarity). Interacts with NPAS2 (By similarity). Interacts with EZH2 (By similarity). Interacts with SUMO3 (By similarity). Interacts with SIRT1 (By similarity). Interacts with AHR (By similarity). Interacts with ID1, ID2 and ID3 (By similarity). Interacts with DDX4 (By similarity). Interacts with OGT (By similarity). Interacts with EED and SUZ12 (By similarity). Interacts with MTA1 (By similarity). Interacts with CIART (By similarity). Interacts with HSP90 (By similarity). Interacts with KAT2B and EP300 (By similarity). Interacts with BHLHE40/DEC1 and BHLHE41/DEC2 (By similarity). Interacts with RELB and the interaction is enhanced in the presence of CLOCK (By similarity). Interacts with PER1, PER2, CRY1 and CRY2 and this interaction requires a translocation to the nucleus (By similarity). Interaction of the CLOCK-BMAL1 heterodimer with PER or CRY inhibits transcription activation (By similarity). Interaction of the CLOCK-BMAL1 with CRY1 is independent of DNA but with PER2 is off DNA (By similarity). The CLOCK-BMAL1 heterodimer interacts with GSK3B (By similarity). Interacts with KDM5A (By similarity). Interacts with KMT2A; in a circadian manner (By similarity). Interacts with UBE3A (By similarity). Interacts with PRKCG (By similarity). Interacts with MAGEL2 (By similarity). Interacts with NCOA2 (By similarity). Interacts with THRAP3 (By similarity). The CLOCK-BMAL1 heterodimer interacts with PASD1 (By similarity)…
messages: Cytoplasm
messages: Nucleus
messages: O-glycosylated; contains O-GlcNAc. O-glycosylation by OGT prevents protein degradation by inhibiting ubiquitination. It also stabilizes the CLOCK-BMAL1 heterodimer thereby increasing CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2/3 and CRY1/2.
messages: PML body
messages: Phosphorylated upon dimerization with CLOCK. Phosphorylation enhances the transcriptional activity, alters the subcellular localization and decreases the stability of the CLOCK-BMAL1 heterodimer by promoting its degradation. Phosphorylation shows circadian variations in the liver with a peak between CT10 to CT14. Phosphorylation at Ser-90 by CK2 is essential for its nuclear localization, its interaction with CLOCK and controls CLOCK nuclear entry. Dephosphorylation at Ser-78 is important for dimerization with CLOCK and transcriptional activity.
messages: Sumoylated on Lys-259 upon dimerization with CLOCK. Predominantly conjugated to poly-SUMO2/3 rather than SUMO1 and the level of these conjugates undergo rhythmic variation, peaking at CT9-CT12. Sumoylation localizes it exclusively to the PML body and promotes its ubiquitination in the PML body, ubiquitin-dependent proteasomal degradation and the transcriptional activity of the CLOCK-BMAL1 heterodimer.
messages: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a …
messages: Ubiquitinated, leading to its proteasomal degradation. Deubiquitinated by USP9X.
messages: Undergoes lysosome-mediated degradation in a time-dependent manner in the liver.

10116:Tgfb1
gene id: 10116:Tgfb1
uniprot id: A6J986
uniprot id: P17246
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in the bone matrix (PubMed:2070682). Expressed in cardiomyocytes (PubMed:26858265).
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Homodimer; disulfide-linked. Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction.
messages: Homodimer; disulfide-linked. Interacts with the serine proteases, HTRA1 and HTRA3: the interaction with either inhibits TGFB1-mediated signaling and the HTRA protease activity is required for this inhibition. May interact with THSD4; this interaction may lead to sequestration by FBN1 microfibril assembly and attenuation of TGFB signaling. Interacts with CD109, DPT and ASPN. Interacts with EFEMP2. Interacts with TSKU; the interaction contributes to regulation of the hair cycle.
messages: Homodimer; disulfide-linked. Interacts with transforming growth factor beta-1 (TGF-beta-1) chain; interaction is non-covalent and maintains TGF-beta-1 in a latent state; each latency-associated peptide (LAP) monomer interacts with TGF-beta-1 in the other monomer. Interacts with LTBP1; leading to regulation of TGF-beta-1 activation. Interacts with LRRC32/GARP; leading to regulation of TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Interacts with LRRC33/NRROS; leading to regulation of TGF-beta-1 activation in macrophages and microglia. Interacts (via cell attachment site) with integrins ITGAV and ITGB6 (ITGAV:ITGB6), leading to release of the active TGF-beta-1. Interacts with NREP; the interaction results in a decrease in TGFB1 autoinduction. Interacts with HSP90AB1; inhibits latent TGFB1 activation.
messages: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1 (By similarity). Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). While expressed by many cells types, TGF-beta-1 only has a very localized range of action within cell environment thanks to fine regulation of its activation by Latency-associated peptide chain (LAP) and 'milieu molecules' (PubMed:2070682). Plays an important role in bone remodeling: acts as a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (PubMed:2070682). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner (By similarity). At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development (By similarity). At low concentrations in concert with IL-6 an…
messages: N-glycosylated. Deglycosylation leads to activation of Transforming growth factor beta-1 (TGF-beta-1); mechanisms triggering deglycosylation-driven activation of TGF-beta-1 are however unclear.
messages: Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia. Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1.
messages: Secreted
messages: The 'straitjacket' and 'arm' domains encircle the Transforming growth factor beta-1 (TGF-beta-1) monomers and are fastened together by strong bonding between Lys-56 and Tyr-103/Tyr-104.
messages: The cell attachment site motif mediates binding to integrins (ITGAV:ITGB6 or ITGAV:ITGB8). The motif locates to a long loop in the arm domain called the bowtie tail. Integrin-binding stabilizes an alternative conformation of the bowtie tail. Activation by integrin requires force application by the actin cytoskeleton, which is resisted by the 'milieu molecules' (such as LTBP1, LRRC32/GARP and/or LRRC33/NRROS), resulting in distortion of the prodomain and release of the active TGF-beta-1.
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: Transforming growth factor beta-1 proprotein: The precursor proprotein is cleaved in the Golgi apparatus by FURIN to form Transforming growth factor beta-1 (TGF-beta-1) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-1 inactive.
messages: extracellular matrix

10116:Cadm2
gene id: 10116:Cadm2
uniprot id: A0A8I6A950
uniprot id: Q1WIM2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes (By similarity).
messages: Belongs to the nectin family.
messages: Cell membrane
messages: Glycosylation at Asn-51 reduces adhesive binding.
messages: Synapse
messages: axon

10116:B3gntl1
gene id: 10116:B3gntl1
uniprot id: Q6GV29
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.
messages: Putative glycosyltransferase.

10116:Rab11fip1
gene id: 10116:Rab11fip1
uniprot id: Q3B7T9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and phagocytosis (By similarity).
messages: Homooligomer. Interacts with RAB4A, RAB11A, RAB11B and RAB25 (By similarity).
messages: Recycling endosome
messages: phagosome membrane

10116:Itpka
gene id: 10116:Itpka
uniprot id: A6HPH2
uniprot id: P17105
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activated by calcium/calmodulin.
messages: Belongs to the inositol phosphokinase (IPK) family.
messages: Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis.
messages: cytoskeleton

10116:Washc2c
gene id: 10116:Washc2c
uniprot id: Q80X08
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC and retriever complexes subunits COMMD1 and CCDC93 as well as the retrievere complex subunit VPS35L.
messages: Belongs to the FAM21 family.
messages: Cell membrane
messages: Component of the WASH core complex also described as WASH regulatory complex (SHRC) composed of WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5; in the complex interacts (via N-terminus) directly with WASHC1. The WASH core complex associates with the F-actin-capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and CAPZB) in a transient or substoichiometric manner which was initially described as WASH complex. Interacts with VPS35; mediates the association with the retromer CSC complex. Interacts with FKBP15. Interacts with CCDC93, CCDC22, VPS35L; indicative for an association of the WASH core complex with the CCC and retriever complexes (By similarity). Directly interacts with TBC1D23 (By similarity).
messages: Early endosome membrane
messages: The LFa (leucine-phenylalanine-acidic) motif bind directly to VPS35 of retromer CSC; adjacent motifs can act cooperatively to bind multiple CSCs, although there is significant variability in the affinities of different motifs for retromer.

10116:Olr703
gene id: 10116:Olr703
uniprot id: A0A8I6GAX7
uniprot id: A6HN38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Csgalnact1
gene id: 10116:Csgalnact1
uniprot id: B5DEY9
uniprot id: F7FDK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

10116:Elp3
gene id: 10116:Elp3
uniprot id: A6K6K0
uniprot id: D4ACM1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

10116:Chrd
gene id: 10116:Chrd
uniprot id: A0A140TA94
uniprot id: A6JS78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chordin family.
messages: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
messages: Secreted

10116:Acta2
gene id: 10116:Acta2
uniprot id: B0BMT0
uniprot id: P62738
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-75 by SETD3.
messages: Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (By similarity).
messages: N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP.
messages: Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
messages: cytoskeleton

10116:Prpf38b
gene id: 10116:Prpf38b
uniprot id: A6HV34
uniprot id: Q6AXY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: May be required for pre-mRNA splicing.
messages: Nucleus

10116:Hars1
gene id: 10116:Hars1
uniprot id: Q4QQV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

10116:Nrg4
gene id: 10116:Nrg4
uniprot id: A6J4P4
names: Caution
names: Similarity
messages: Belongs to the neuregulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:ND4L
gene id: 10116:ND4L
uniprot id: P05507
uniprot id: Q7H113
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane

10116:Iars1
gene id: 10116:Iars1
uniprot id: A6J6V4
uniprot id: F1LS86
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

10116:Dll1
gene id: 10116:Dll1
uniprot id: P97677
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Homodimer. Interacts with TJP1. Interacts with MAGI1 (via PDZ domain); forms a complex with CTNNB1 and CDH2 and promotes recruitment to the adherens junction and stabilization on the cell surface. Interacts with PSEN1; undergoes a presenilin-dependent gamma-secretase cleavage that releases a Dll1-intracellular form. Interacts with MFAP5. Interacts with MIB1. Interacts with NEURL1B; leads to ubiquitination. Interacts with NEURL1 (By similarity). Interacts with SYNJ2BP; enhances DLL1 protein stability, and promotes Notch signaling in endothelial cells. Interacts with MAGI1, MAGI2, MAGI3 and MPDZ (By similarity). Interacts (via ubiquitin) with EPN1 (via IUM domain); binding with NOTCH1 attached to neighboring cell, promotes ligand ubiquitination and EPN1 interaction, leading to NECD transendocytosis and Notch signaling (PubMed:22658936). Interacts with NOTCH1 (PubMed:28089369).
messages: Membrane raft
messages: O-fucosylated. Can be elongated to a disaccharide by MFNG.
messages: Phosphorylated in a membrane association-dependent manner. Phosphorylation at Ser-688 requires the presence of Ser-685, whereas phosphorylation at Thr-630 and Ser-685 occur independently of the other sites. Phosphorylation is required for full ligand activity in vitro and affects surface presentation, ectodomain shedding, and endocytosis.
messages: Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (By similarity). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (PubMed:22658936). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (By similarity). Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner. During neocortex development, Dll1-Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries. During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway. At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling path…
messages: Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation (By similarity). Ubiquitinated; promotes recycling back to the plasma membrane and confers a strong affinity for NOTCH1. Mono- and multi-ubiquitinated. Multi-ubiquitination of Lys-605 by MIB1 promotes both cis and trans-interaction with NOTCH1, as well as activation of Notch signaling. Ubiquitinated by NEURL1B (By similarity).
messages: adherens junction

10116:Mylk3
gene id: 10116:Mylk3
uniprot id: E9PT87
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Calmodulin-dependent kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes. Increases cardiomyocyte contractility.
messages: Cytoplasm
messages: Expressed in cardiomyocytes (at protein level). Up-regulated in heart after experimental myocardial infarction at the mRNA level.
messages: Phosphorylated on serine residues.
messages: Up-regulated in the heart from 1 week after birth through adulthood.
messages: by NRG1 (at protein level).

10116:Mpv17
gene id: 10116:Mpv17
uniprot id: A6HA73
uniprot id: Q5BK62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis. Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance (By similarity). May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (By similarity).

10116:Tra2b
gene id: 10116:Tra2b
uniprot id: P62997
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Found in a pre-mRNA exonic splicing enhancer (ESE) complex with TRA2B/SFRS10, SNRNP70, SNRPA1 and SRRM1. Binds to A3 enhancer proteins SFRS4, SFRS5, SFRS6 and SFRS9. Interacts with CPSF6, RBMY1A1, RNPS1 and phosphorylated SFRS13A (By similarity). Interacts with RBMX and SAFB/SAFB1 (PubMed:9671816, PubMed:19282290). Interacts with ILDR1 (via C-terminus) and ILDR2 (By similarity).
messages: Induced by reoxygenation following hypoxia and by exposure to silica. Repressed by interferon gamma, LPS and TPA.
messages: Nucleus
messages: Phosphorylated in the RS domains.
messages: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA (By similarity).

10116:Gfi1
gene id: 10116:Gfi1
uniprot id: Q07120
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expression enhanced late after interaction of IL-2 with its receptor, approximately when cells enter S phase.
messages: Interacts with U2AF1L4. Component of RCOR-GFI-KDM1A-HDAC complexes. Interacts directly with RCOR1, KDM1A and HDAC2. Also interacts with HDAC1. regions. Interacts (via the zinc-finger domain) with ARIH2; the interaction prevents GFI1 ubiquitination and proteasomal degradation. Interacts with PIAS3; the interaction relieves the inhibitory effect of PIAS3 on STAT3-mediated transcriptional activity. Forms a complex with EHMT2 and HDAC1 to promote 'Lys-9' dimethylation of H3 (H3K9Me2) and repress expression of target genes. Interacts directly with EHMT2. Component of the GFI1-AJUBA-HDAC1 repressor complex. Interacts directly with AJUBA (via ITS LIM domains); the interaction results in the HDAC-dependent corepression of a subset of GFI1 target genes and, occurs independent of the SNAG domain. Interacts with SPI1; the interaction inhibits SPI1 transcriptional activity targeted at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity). Interacts with RUNX1T1; the interaction represses HDAC-mediated transcriptional activity. Interacts with RELA; the interaction occurs on liposaccharide (LPS) stimulation controls RELA DNA binding activity and regulates endotoxin-mediated TOLL-like receptor inflammatory response (By similarity). Interacts (via the C-terminal zinc fingers) with ZBTB17; the interaction results in the recruitment of GFI1 to the CDKN1A/p21 promoter and repression of CDKN1A/p21 transcription.
messages: Nucleus
messages: Restricted to lymphoid tissues and testes in adult animals.
messages: The SNAG domain of GFIs is required for nuclear location and for interaction with some corepressors.
messages: Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity). Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 promoter region. Implicated in the maintenance of inner ear hair cells (By similarity).
messages: Ubiquitinated.
messages: Zinc fingers 3,4 and 5 are required for DNA binding and for interaction with SPI1.

10116:LOC100363116
gene id: 10116:LOC100363116
uniprot id: A6JCI3
uniprot id: Q505I4
names: Similarity
messages: Belongs to the UPF0235 family.

10116:Tmem131
gene id: 10116:Tmem131
uniprot id: A0A8I5ZM29
uniprot id: A0A8I6ACW0
names: Similarity
messages: Belongs to the TMEM131 family.

10116:Cdh6
gene id: 10116:Cdh6
uniprot id: P55280
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
messages: Cell membrane
messages: Highly expressed in kidney and brain.
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

10116:Acsl6
gene id: 10116:Acsl6
uniprot id: A0A8I6B3S2
uniprot id: P33124
names: Caution
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 5 rat isozymes encoded by different genes have been described. ACSL6 corresponds to isozyme 2 (ACS2).
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:28209804). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Contains exon 13. No differences in the affinity for fatty acids and CoA. Decreased affinity for ATP. Could play an important role at lower ATP levels. Expressed at lower level in the brain compared to isoform 1.
messages: Contains exon 14.
messages: Endoplasmic reticulum membrane
messages: Expressed predominantly in brain and, to a much lesser extent, in heart and adrenal.
messages: Isoform 1 is detected 10 days after birth, and increased in a coordinate fashion during the development of brain, and the amount did not decrease when myelination was completed.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane
messages: Mitochondrion outer membrane
messages: Peroxisome membrane

10116:Il13ra2
gene id: 10116:Il13ra2
uniprot id: A6KGB0
uniprot id: G3V9B6
names: Subcellular Location Annotation
messages: Membrane

10116:Ints14
gene id: 10116:Ints14
uniprot id: Q66H58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

10116:Rps27
gene id: 10116:Rps27
uniprot id: A6J6K4
uniprot id: Q71TY3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for proper rRNA processing and maturation of 18S rRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: Cytoplasm
messages: Expressed in the striatum, cerebellum, hippocampus, hypothalamus, pons, heart and liver.
messages: nucleolus

10116:Ube2z
gene id: 10116:Ube2z
uniprot id: Q3B7D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.
messages: Cytoplasm
messages: Nucleus

10116:Cpe
gene id: 10116:Cpe
uniprot id: P15087
uniprot id: Q5U322
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: An autoantigen recognized by serum of pretype I diabetes.
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Expressed in brain, heart and anterior pituitary gland. Also expressed in pancreatic islets and adrenal gland.
messages: Interacts with Secretogranin III/SCG3.
messages: Interacts with secretogranin III/SCG3.
messages: Membrane
messages: Secreted
messages: Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.
messages: secretory vesicle
messages: secretory vesicle membrane

10116:Capn1
gene id: 10116:Capn1
uniprot id: P97571
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by micromolar concentrations of calcium and inhibited by calpastatin.
messages: Belongs to the peptidase C2 family.
messages: Binds 4 Ca(2+) ions.
messages: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-364', 'Gly-377' and 'His-399'. Cleaves and activates caspase-7 (CASP7).
messages: Cell membrane
messages: Cytoplasm
messages: Forms a heterodimer with a small (regulatory) subunit CAPNS1.
messages: Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms (By similarity).

10116:Tpd52
gene id: 10116:Tpd52
uniprot id: A6IH66
names: Similarity
messages: Belongs to the TPD52 family.

10116:Tasor2
gene id: 10116:Tasor2
uniprot id: D3ZVI2
names: Similarity
messages: Belongs to the TASOR family.

10116:Lrrfip1
gene id: 10116:Lrrfip1
uniprot id: A0A8I5Y1S8
uniprot id: A0A8I5Y5U1
uniprot id: A6JQN9
uniprot id: A6JQP0
uniprot id: A6JQP6
uniprot id: Q66HF9
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LRRFIP family.
messages: Cytoplasm
messages: Homodimer. May also form higher oligomers. Interacts with FLII (By similarity). Interacts with MYD88 (By similarity). Competes with FLII for MyD88-binding, even in the absence of LPS (By similarity).
messages: Nucleus
messages: The DNA-binding domain is intrinsically unstructured.
messages: The coiled coil mediates dimerization.
messages: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity).
messages: Up-regulated after artery wall injury (at protein level).

10116:Mmp17
gene id: 10116:Mmp17
uniprot id: A6J0R3
uniprot id: D3ZXJ0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

10116:Ddx52
gene id: 10116:Ddx52
uniprot id: A6HHJ6
uniprot id: Q99PT0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
messages: RNA helicase.
messages: Required for efficient ribosome biogenesis. May control cell cycle progression by regulating translation of mRNAs that contain a terminal oligo pyrimidine (TOP) motif in their 5' UTRs, such as GTPBP4.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

10116:Sf3a2
gene id: 10116:Sf3a2
uniprot id: Q6AXT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3A2 family.
messages: Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62 and SF3A1/SAP114. SF3A1 functions as scaffold that interacts directly with both SF3A2 and SF3A3. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the mature 17S U2 small nuclear ribonucleoprotein complex (17S U2 snRNP). Identified in the spliceosome 'E' complex, a precursor of the spliceosome 'A' complex. Identified in the spliceosome 'A' and 'B' complexes. Identified in the spliceosome 'C' complex. Interacts with HTATSF1.
messages: Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron.
messages: Nucleus

10116:Gpc4
gene id: 10116:Gpc4
uniprot id: Q642B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

10116:Tulp2
gene id: 10116:Tulp2
uniprot id: Q5XFX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

10116:Ro60
gene id: 10116:Ro60
uniprot id: A6ICP3
uniprot id: D3ZRN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

10116:Rab15
gene id: 10116:Rab15
uniprot id: P35289
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Expressed predominantly in neural tissues.
messages: May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.
messages: The GTP bound form of RAB15 interacts with REP15. Interacts (GTP-bound form) with MICAL1, MICAL3, MICALCL, EHBP1 and EHBP1L1.

10116:Hyal5
gene id: 10116:Hyal5
uniprot id: F7FB21
uniprot id: Q5BK36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Membrane

10116:Zfyve27
gene id: 10116:Zfyve27
uniprot id: A0A140TAG8
uniprot id: Q6P7B7
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Can form homooligomers (monomers, dimers and tetramers). Interacts with FKBP8; may negatively regulate ZFYVE27 phosphorylation. Interacts with VAPA (via MSP domain); may regulate ZFYVE27 retention in the endoplasmic reticulum and its function in cell projections formation. Interacts with VAPB (via MSP domain) (By similarity). Interacts with RAB11A (GDP-bound form); regulates RAB11A (PubMed:17082457). Interacts with RAB11B (GDP-bound form), REEP1, REEP5, ATL1, ATL2, ATL3, SPAST, SURF4, KIF5A, KIF5B, KIF5C and RTN3 (By similarity).
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (PubMed:17082457). Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner (By similarity).
messages: Membrane
messages: Phosphorylated. Phosphorylation is induced by NGF through the MAPK/ERK pathway and modulates interaction with RAB11A (By similarity).
messages: Recycling endosome membrane
messages: growth cone membrane

10116:Tmtc3
gene id: 10116:Tmtc3
uniprot id: A6IG92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

10116:Gnrhr
gene id: 10116:Gnrhr
uniprot id: P30969
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expression oscillates in a diurnal and melatonin-dependent fashion in the preoptic area (POA) region in the hypothalamus, with maximal expression attained during the dark phase of the light/dark cycle.
messages: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.

10116:Bid
gene id: 10116:Bid
uniprot id: A8ASI9
uniprot id: Q9JLT6
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2.
messages: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2. Interacts with PLEKHN1.
messages: Induces caspase activation and apoptosis (By similarity). Allows the release of cytochrome c (By similarity).
messages: Induces caspases and apoptosis. Counters the protective effect of BCL2.
messages: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
messages: Interacts with ITCH (By similarity). Interacts with MTCH2 (By similarity).
messages: Membrane
messages: Mitochondrion membrane
messages: Mitochondrion outer membrane
messages: TNF-alpha induces caspase-mediated cleavage into a major p15 and minor p13 and p11 products (By similarity). Cleaved by CASP6 into a major p15 and minor p13 products, leading to release of cytochrome c and subsequent nonalcoholic steatohepatitis (By similarity).
messages: Ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation.

10116:Ap3b1
gene id: 10116:Ap3b1
uniprot id: A6I4W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

10116:Vom2r22
gene id: 10116:Vom2r22
uniprot id: D3ZFX7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Eif2ak1
gene id: 10116:Eif2ak1
uniprot id: Q63185
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by autophosphorylation; phosphorylated predominantly on serine and threonine residues, but also on tyrosine residues. Autophosphorylation at Thr-486 is required for kinase activation. The active autophosphorylated form apparently is largely refractory to cellular heme fluctuations.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
messages: Cytoplasm
messages: In normal conditions, the protein kinase activity is inhibited; inhibition is relieved by various stress conditions (By similarity). Inhibited by heme: in presence of heme, forms a disulfide-linked inactive homodimer (By similarity). Heme depletion relieves inhibition and stimulates kinase activity by autophosphorylation. Inhibited by the heme metabolites biliverdin and bilirubin. Induced by oxidative stress generated by arsenite treatment. Binding of nitric oxide (NO) to the heme iron in the N-terminal heme-binding domain activates the kinase activity, while binding of carbon monoxide (CO) suppresses kinase activity (By similarity). Protein kinase activity is also activated upon binding to DELE1 in response to various stress, triggering the integrated stress response (ISR): activated by full-length DELE1 in response to iron deficiency, while it is activated by the processed form of DELE1 (S-DELE1) in response to mitochondrial stress (By similarity).
messages: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming. Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. It thereby plays an essential protective role for RBC survival in anemias of iron deficiency. Iron deficiency also triggers activation by full-length DELE1. Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (By similarity).
messages: Synthesized in an inactive form that binds to the N-terminal domain of CDC37. Has to be associated with a multiprotein complex containing Hsp90, CDC37 and PPP5C for maturation and activation by autophosphorylation. The phosphatase PPP5C modulates this activation (By similarity). Homodimer; homodimerizes in presence of heme, forming a disulfide-linked inactive homodimer (By similarity). Interacts with DELE1; binds both to full-length DELE1 and processed form of DELE1 (S-DELE1) in response to stress, leading to activate its protein kinase activity and trigger the integrated stress response (ISR) (By similarity).
messages: Was reported to be induced by various cytochrome P450 inducers, including phenobarbital, dexamethasone, rifampicin and barbituric acid in its autophosphorylated state, and that carbamazepine has no effect. Was also reported to be expressed predominantly in erythroid cells, and at much lower levels, expressed in hepatocytes (at protein level). However, this paper has been retracted because of improper data manipulation, reuse, and analyses.

10116:Rhox8
gene id: 10116:Rhox8
uniprot id: Q4TU75
names: Subcellular Location Annotation
messages: Nucleus

10116:Gaa
gene id: 10116:Gaa
uniprot id: A6HL76
uniprot id: M0R544
uniprot id: Q6P7A9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome
messages: Lysosome membrane

10116:Nup88
gene id: 10116:Nup88
uniprot id: A6HGA6
uniprot id: O08658
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of nuclear pore complex.
messages: Interacts with NUP214/CAN. Interacts with NUP62 and NUP98 (By similarity).
messages: nuclear pore complex

10116:Irak2
gene id: 10116:Irak2
uniprot id: A6IBT6
uniprot id: Q4QQS0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Asn-335 is present instead of the conserved Asp which is expected to be an active site residue.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
messages: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1 (By similarity).
messages: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.
messages: The protein kinase domain is predicted to be catalytically inactive.

10116:Slc43a3
gene id: 10116:Slc43a3
uniprot id: A6HMS4
uniprot id: D4A832
names: Subcellular Location Annotation
messages: Membrane

10116:Map2k1
gene id: 10116:Map2k1
uniprot id: A6J5B8
uniprot id: Q01986
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
messages: Cytoplasm
messages: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
messages: Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3/ERK1 and RGS14 (PubMed:19319189). Forms a heterodimer with MAP2K2/MEK2 (By similarity). Forms heterodimers with KSR2 which further dimerize to form tetramers (By similarity). Interacts with KSR1 or KSR2 and BRAF; the interaction with KSR1 or KSR2 mediates KSR1-BRAF or KSR2-BRAF dimerization (By similarity). Interacts with ARBB2, LAMTOR3, MAPK1/ERK2 and RAF1 (PubMed:7565670, PubMed:9733512, PubMed:11226259, PubMed:14993270). Interacts with MAPK1/ERK2 (By similarity). Interacts with MORG1 (By similarity). Interacts with PPARG (By similarity). Interacts with VRK2 (By similarity). Interacts with SGK1 (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with KAT7; the interaction promotes KAT7 phosphorylation (By similarity). Interacts with RAF1 and NEK10; the interaction is required for ERK1/2-signaling pathway activation in response to UV irradiation (By similarity). Interacts with TRAF3IP3 (By similarity).
messages: Membrane
messages: Nucleus
messages: Phosphorylation at Ser-218 and Ser-222 by MAP kinase kinase kinases (BRAF or MEKK1) positively regulates kinase activity (PubMed:10769026). Also phosphorylated at Thr-292 by MAPK1/ERK2 and at Ser-298 by PAK (PubMed:12876277, PubMed:14993270). MAPK1/ERK2 phosphorylation of Thr-292 occurs in response to cellular adhesion and leads to inhibition of Ser-298 phosphorylation by PAK (PubMed:14993270). Autophosphorylated at Ser-218 and Ser-222, autophosphosphorylation is promoted by NEK10 following UV irradiation (By similarity).
messages: Ras proteins such as HRAS mediate the activation of RAF proteins such as RAF1 or BRAF which in turn activate extracellular signal-regulated kinases (ERK) through MAPK (mitogen-activated protein kinases) and ERK kinases MAP2K1/MEK1 and MAP2K2/MEK2. Activation occurs through phosphorylation of Ser-218 and Ser-222. MAP2K1/MEK1 binds KSR1 or KSR2 releasing the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains (By similarity). This allows KSR1 or KSR2 dimerization with BRAF leading to BRAF activation and phosphorylation of MAP2K1 (By similarity). MAP2K1/MEK1 is also the target of negative feed-back regulation by its substrate kinases, such as MAPK1/ERK2. These phosphorylate MAP2K1/MEK1 on Thr-292, thereby facilitating dephosphorylation of the activating residues Ser-218 and Ser-222. Inhibited by serine/threonine phosphatase 2A.
messages: The proline-rich region localized between residues 270 and 307 is important for binding to RAF1 and activation of MAP2K1/MEK1.
messages: centrosome
messages: spindle pole body

10116:Eif3g
gene id: 10116:Eif3g
uniprot id: Q5RK09
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus) (By similarity). Interacts with DHX33; the interaction is independent of RNA (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
messages: perinuclear region

10116:Psmd9
gene id: 10116:Psmd9
uniprot id: Q9WTV5
names: Function
names: Similarity
names: Subunit
messages: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process (By similarity).
messages: Belongs to the proteasome subunit p27 family.
messages: Interacts with PSMC3. Part of a transient complex (modulator) containing PSMD9, PSMC6 and PSMC3 formed during the assembly of the 26S proteasome (By similarity).

10116:Olr1106
gene id: 10116:Olr1106
uniprot id: A6KC71
uniprot id: D3ZVJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ptk2b
gene id: 10116:Ptk2b
uniprot id: A6K6M1
uniprot id: P70600
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated in response to stimuli that lead to increased intracellular Ca(2+) levels; this activation is indirect and may be mediated by calcium-mediated production of reactive oxygen species (ROS). Activated by autophosphorylation at Tyr-402; this creates a binding site for SRC family kinases and leads to phosphorylation at additional tyrosine residues. Phosphorylation at Tyr-402, Tyr-579 and Tyr-580 is required for optimal kinase activity (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Highly expressed in pulmonary vein endothelial cells, lung and brain (at protein level). Isoform 1 is expressed at high levels in the brain (hippocampus, cerebral cortex and olfactory bulb) and poorly in the spleen and other tissues, whereas isoforms 2 and 3 are expressed in the spleen and brain (highest in cerebellum).
messages: Homodimer, or homooligomer. Interacts with NPHP1, ASAP1, ASAP2, ARHGAP26, SKAP2 and TGFB1I1. The Tyr-402 phosphorylated form interacts with SRC (via SH2 domain) and SRC family members. Forms a signaling complex with EPHA1, LCK and phosphatidylinositol 3-kinase; upon activation by EFNA1. Interacts with GRB2 (via SH2 domain). Interacts with P53/TP53 and MDM2. Interacts with MYLK. Interacts with BCAR1. Interacts with RB1CC1. Interacts with RHOU. Interacts with VAV1. Interacts with PDPK1. Interacts with LPXN and PTPN12 (By similarity). Interacts with SIRPA and SH2D3C. Interacts (hypophosphorylated) with PXN. Interacts with ARHGAP10. Interacts with KCNA2 (PubMed:11739373).
messages: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376' (By similarity). Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracel…
messages: Nucleus
messages: Phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration; this activation is indirect and may be mediated by production of reactive oxygen species (ROS). Tyr-402 is the major autophosphorylation site, but other kinases can also phosphorylate Tyr-402. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-402 promotes interaction with SRC and SRC family members, leading to phosphorylation at Tyr-579; Tyr-580 and Tyr-881. Phosphorylation at Tyr-881 is important for interaction with GRB2. Phosphorylated on tyrosine residues upon activation of FGR and PKC. Recruitment by NPHP1 to cell matrix adhesions initiates Tyr-402 phosphorylation. In monocytes, adherence to substrata is required for tyrosine phosphorylation and kinase activation. Angiotensin II, thapsigargin and L-alpha-lysophosphatidic acid (LPA) also induce autophosphorylation and increase kinase activity. Phosphorylation by MYLK promotes ITGB2 activation and is thus essential to trigger neutrophil transmigration during lung injury. Dephosphorylated by PTPN12 (By similarity).
messages: cell cortex
messages: focal adhesion
messages: lamellipodium
messages: perinuclear region

10116:Src
gene id: 10116:Src
uniprot id: Q9WUD9
names: Activity Regulation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: Cell membrane
messages: Dephosphorylated at Tyr-530 by PTPRJ. Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src (By similarity). Dephosphorylated by PTPRJ at Tyr-419. Normally maintained in an inactive conformation with the SH2 domain engaged with Tyr-530, the SH3 domain engaged with the SH2-kinase linker, and Tyr-419 dephosphorylated. Dephosphorylation of Tyr-530 as a result of protein tyrosine phosphatase (PTP) action disrupts the intramolecular interaction between the SH2 domain and Tyr-530, Tyr-419 can then become autophosphorylated, resulting in SRX activation. Phosphorylation of Tyr-530 by CSK allows this interaction to reform, resulting in SRC inactivation. CDK5-mediated phosphorylation at Ser-75 targets SRC to ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. Phosphorylated by PTK2/FAK1; this enhances kinase activity (By similarity). Phosphorylated by PTK2B/PYK2; this enhances kinase activity. Upon activation of IL6ST by IL6, Tyr-419 is phosphorylated and Tyr-530 dephosphorylated (By similarity).
messages: Displays enhanced levels of autophosphorylation at Tyr-419 compared to isoform 1 (PubMed:26026271). Shows reduced phosphorylation at Tyr-527 compared to isoforms 1 and 2 (PubMed:26026271).
messages: Displays enhanced levels of autophosphorylation at Tyr-419 compared to isoform 1.
messages: Displays reduced levels of autophosphorylation at Tyr-419 compared to isoforms 2 and 3.
messages: Expressed at very low levels in the forebrain.
messages: Expressed in the brain with highest expression in the pyramidal layers of the hippocampus and the granular layer of the dentate gyrus and moderate expression in cortical regions, with higher levels in the superficial layers than in the deep layers. May be neuron-specific.
messages: Mitochondrion inner membrane
messages: Myristoylated at Gly-2, and this is essential for targeting to membranes.
messages: Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (By similarity). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-…
messages: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity.
messages: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (PubMed:26026271). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (PubMed:26026271). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (PubMed:26026271). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (PubMed:28220894).
messages: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (PubMed:26026271). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (PubMed:26026271). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (PubMed:26026271). Plays a role in neurite elongation (PubMed:28220894).
messages: Nucleus
messages: Part of a complex comprised of PTPRA, BCAR1, BCAR3 (via SH2 domain) and SRC; the formation of the complex is dependent on integrin mediated-tyrosine phosphorylation of PTPRA (By similarity). Interacts with DDEF1/ASAP1; via the SH3 domain (By similarity). Interacts with CCPG1 (By similarity). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By similarity). Interacts with ERBB2, STAT1 and PNN (By similarity). Interacts with CDCP1, TGFB1I1 and TOM1L2 (By similarity). Interacts with the cytoplasmic domain of MUC1, phosphorylates it and increases binding of MUC1 with beta-catenin (By similarity). Interacts with RALGPS1; via the SH3 domain (By similarity). Interacts with CAV2 (tyrosine phosphorylated form) (By similarity). Interacts (via the SH3 domain and the protein kinase domain) with ARRB1; the interaction is independent of the phosphorylation state of SRC C-terminus (PubMed:10995467). Interacts with ARRB1 and ARRB2 (PubMed:10995467) (By similarity). Interacts with SRCIN1 (By similarity). Interacts with NDFIP2 and more weakly with NDFIP1 (By similarity). Interacts with PIK3CA and/or PIK3C2B, PTK2/FAK1 and ESR1 (dimethylated on arginine) (PubMed:8849729). Interacts with FASLG (By similarity). Interacts (via SH2 domain) with the 'Tyr-402' phosphorylated form of PTK2B/PYK2 (PubMed:8849729). Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated) (By similarity). Interacts (via SH2 and SH3 domain) with TNK2 (By similarity). Interacts (via protein kinase domain) with the tyrosine phosphorylated form of RUNX3 (via runt domain) (By similarity). Interacts with TRAF3 (via RING-type zinc finger domain) (By similarity). Interacts with RIGI, MAVS and TBK1 (By similarity). Interacts (via SH2 domain) with RACK1; the interaction is enhanced by tyrosine phosphorylation of RACK1 and inhibits SRC activity (By similarity). Interacts with EPHB1; activates the MAPK/ERK cascade to regulate cell migration (By similarity). Interacts with F…
messages: Phosphorylation by CSK at Tyr-530 inhibits kinase activity. Inhibitory phosphorylation at Tyr-530 is enhanced by heme. Further phosphorylation by CDK1 partially reactivates CSK-inactivated SRC and facilitates complete reactivation by protein tyrosine phosphatase PTPRC. Integrin engagement stimulates kinase activity. Phosphorylation by PTK2/FAK1 enhances kinase activity. Butein and pseudosubstrate-based peptide inhibitors like CIYKYYF act as inhibitors (By similarity). Phosphorylation at Tyr-419 increases kinase activity.
messages: S-nitrosylation is important for activation of its kinase activity.
messages: Ubiquitinated in response to CDK5-mediated phosphorylation. Ubiquitination mediated by CBLC requires SRC autophosphorylation at Tyr-419 and may lead to lysosomal degradation (By similarity).
messages: Up-regulated by MK-801, an uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, mostly in the superficial layers of the parietal, temporal, occipital and frontal cortices.
messages: cytoskeleton
messages: focal adhesion
messages: perinuclear region

10116:Atp6ap1
gene id: 10116:Atp6ap1
uniprot id: A6KRR4
uniprot id: O54715
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Accessory component of the multisubunit proton-transporting vacuolar (V)-ATPase protein pump (PubMed:32165585). Interacts (via N-terminus) with ATP6AP2 (via N-terminus) (PubMed:32165585). Interacts with RNASEK (By similarity). Interacts with TMEM106B (via C-terminus) (By similarity).
messages: Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles (PubMed:32165585). Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). In islets of Langerhans cells, may regulate the acidification of dense-core secretory granules (By similarity).
messages: Belongs to the vacuolar ATPase subunit S1 family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Expressed in brain (at protein level).
messages: N-glycosylated.
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

10116:Mtg2
gene id: 10116:Mtg2
uniprot id: A0A8I6AA18
uniprot id: A6KMC2
uniprot id: Q5XIH5
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

10116:Olr1339
gene id: 10116:Olr1339
uniprot id: A6J3P5
uniprot id: D3ZLT4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Nnmt
gene id: 10116:Nnmt
uniprot id: A6J4A4
uniprot id: D4A605
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

10116:Chrna10
gene id: 10116:Chrna10
uniprot id: A6I720
uniprot id: Q9JLB5
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-subfamily.
messages: Cell membrane
messages: Expressed in the outer hair cells of the cochlea and the neurons of dorsal root ganglia.
messages: Expression in the inner hair cells of the ear is lost at the onset of hearing, around P12. This correlates with a loss of sensitivity of these cells to cholinergic stimuli.
messages: Forms heterooligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 heterooligomers. Interacts with the conotoxin GeXXA (PubMed:26395518). Interacts with the alpha-conotoxin RgIA (PubMed:25740413).
messages: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this leads to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).

10116:Or2n1
gene id: 10116:Or2n1
uniprot id: A0A8I5ZXR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tollip
gene id: 10116:Tollip
uniprot id: A2RUW1
uniprot id: A6HY26
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tollip family.
messages: Both ATG8-interaction motifs (AIM1 and AIM2) are required for the association with ATG8 family proteins.
messages: Component of the signaling pathway of IL-1 and Toll-like receptors (By similarity). Inhibits cell activation by microbial products (By similarity). Recruits IRAK1 to the IL-1 receptor complex (By similarity). Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates (By similarity). The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (By similarity).
messages: Cytoplasm
messages: Early endosome
messages: Endosome
messages: Oligomerizes. Binds to TLR2 and the TLR4-MD2 complex via its C-terminus. Exists as complex with IRAK1 in unstimulated cells. Upon IL-1 signaling, Tollip binds to the activated IL-1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. Found in a complex with TOM1; interacts (via N-terminus) with TOM1 (via GAT domain); the interactions leads to TOM1-recruitment to endosomes and inhibition of TOLLIP binding to PtdIns(3)P (By similarity). Interacts with TOM1L2 (By similarity). Interacts with ATG8 family proteins (via the AIM motifs), and ubiquitin (via the CUE domain) (By similarity). Interacts with LRBA (By similarity).
messages: The N-terminal TOM1-binding domain (residues 1-53) is a disordered domain that partially folds when bound to the GAT domain of TOM1.

10116:Il1rap
gene id: 10116:Il1rap
uniprot id: D1M8S3
uniprot id: Q63621
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the interleukin-1 receptor family.
messages: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system (By similarity). Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity).
messages: Highly expressed in hypothalamus, in the dentate gyrus of hippocampus, cerebral cortex, cerebellum, liver and lung.
messages: Membrane
messages: The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
messages: The interleukin-36 receptor complex is a heterodimer of IL1RL2 and IL1RAP; the association is inhibited by IL36RN (By similarity). The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Associates with IL1R2 to form a non-signaling interleukin-1 receptor complex (By similarity). Interacts with IL-33-bound IL1RL1 to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (independently of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity). Interacts (via the first immunoglobilin domain) with PTPRD (via the third immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (By similarity).

10116:Ano1
gene id: 10116:Ano1
uniprot id: A6HYG7
uniprot id: D4A915
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Prm3
gene id: 10116:Prm3
uniprot id: Q64256
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protamine P3 family.
messages: Chromosome
messages: Nucleus
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
messages: Testis.

10116:Dagla
gene id: 10116:Dagla
uniprot id: Q5YLM1
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Early endosome membrane
messages: Inhibited by 1,2,3-triazole urea covalent inhibitors KT172, DH376 and DO34 (By similarity). Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267. Diacylglycerol lipase activity is inhibited by the phosphorylation of Ser-784 and Ser-810 by CAMK2A (By similarity).
messages: Interacts (via C-terminal) with CAMK2A; leading to the phosphorylation and inhibition of DAGLA enzymatic activity. Interacts (via PPXXF motif) with HOMER1 and HOMER2; this interaction is required for DAGLA membrane localization.
messages: Phosphorylated at Ser-784 and Ser-810 by CAMK2A; phosphorylation by CAMK2A inhibits diacylglycerol lipase activity.
messages: Postsynaptic density membrane
messages: Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG. Has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in regulating 2-AG signaling in the CNS. Controls the activity of 2-AG as a retrograde messenger at neuronal synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation.
messages: dendritic spine membrane

10116:Steap4
gene id: 10116:Steap4
uniprot id: A6K246
uniprot id: Q4V8K1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STEAP family.
messages: Can also utilize the flavins FMN and riboflavin.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homotrimer. Interacts with PTK2/FAK1; the interaction may regulate PTK2 phosphorylation.
messages: Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed:23733181). Can also reduce Cu(2+) to Cu(1+) (PubMed:23733181). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (By similarity). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (By similarity). Inhibits anchorage-independent cell proliferation (By similarity).
messages: Membrane

10116:Eln
gene id: 10116:Eln
uniprot id: Q99372
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the elastin family.
messages: Down-regulated by DTR via activation of EGFR.
messages: Elastin is formed through the cross-linking of its soluble precursor tropoelastin. Cross-linking is initiated through the action of lysyl oxidase on exposed lysines to form allysine. Subsequent spontaneous condensation reactions with other allysine or unmodified lysine residues result in various bi-, tri-, and tetrafunctional cross-links. The most abundant cross-links in mature elastin fibers are lysinonorleucine, allysine aldol, desmosine, and isodesmosine.
messages: Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
messages: Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity).
messages: The polymeric elastin chains are cross-linked together into an extensible 3D network. Forms a ternary complex with BGN and MFAP2. Interacts with MFAP2 via divalent cations (calcium > magnesium > manganese) in a dose-dependent and saturating manner. Interacts with FBLN5 and FBN1. Forms a ternary complex with FBN1 and FBLN2 or FBLN5. Interacts with MFAP4 in a Ca (2+)-dependent manner; this interaction promotes ELN self-assembly (By similarity). Interacts with EFEMP2 with moderate affinity (By similarity).
messages: extracellular matrix

10116:Cap1
gene id: 10116:Cap1
uniprot id: A6IS11
uniprot id: Q08163
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
messages: Homodimer. Binds actin monomers (By similarity).
messages: In all cell and tissue types examined.
messages: Membrane

10116:Plpp7
gene id: 10116:Plpp7
uniprot id: Q5FVJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Endoplasmic reticulum membrane
messages: Homo- and heterooligomer. Interacts with MTOR; controls MTOR-dependent IGF2 expression during myoblast differentiation (By similarity).
messages: Membrane
messages: Nucleus envelope
messages: Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity).

10116:Polr3d
gene id: 10116:Polr3d
uniprot id: F7EKD9
uniprot id: Q4FZS9
names: Subcellular Location Annotation
messages: Nucleus

10116:Tle7
gene id: 10116:Tle7
uniprot id: A0A8I6AID4
uniprot id: F1LTK8
names: Similarity
messages: Belongs to the WD repeat Groucho/TLE family.

10116:Pde4b
gene id: 10116:Pde4b
uniprot id: P14646
names: Activity Regulation
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by phosphorylation at Ser-56. Mutagenesis of Ser-56 abolishes activation.
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions.
messages: Binds 2 divalent metal cations per subunit. Site 2 has a preference for magnesium and/or manganese ions.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in brain, heart, lung and liver.
messages: Expressed in liver and brain.
messages: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
messages: In Sertoli cells, induced by FSH. In the pineal gland, exhibits night/day variations with a 7-fold increased expression at night. Up-regulation is due to a large degree to the release of norepinephrine from nerve terminals in the pineal gland and cAMP signaling pathway.
messages: Inhibited by rolipram.
messages: Interacts with DISC1.
messages: Widely expressed.

10116:Or2y15
gene id: 10116:Or2y15
uniprot id: A6HDW6
uniprot id: D3ZQ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Krt23
gene id: 10116:Krt23
uniprot id: Q6IFW4
names: Similarity
messages: Belongs to the intermediate filament family.

10116:Scd
gene id: 10116:Scd
uniprot id: A6JHF9
uniprot id: P07308
names: Cofactor
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Desaturase has a half-life of only 4 hours.
messages: Detected in liver (at protein level) (PubMed:2892838). Detected in adipose tissue. Detected in liver when rats are kept on a fat-free diet, but not when their food contains unsaturated fatty acids.
messages: Endoplasmic reticulum membrane
messages: Expected to bind 2 Fe(2+) ions per subunit.
messages: Membrane
messages: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:2892838, PubMed:7947684). Catalyzes the insertion of a cis double bond at the Delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:2892838, PubMed:7947684). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (PubMed:7947684). Required for normal development of sebaceous glands. Required for the biosynthesis of normal levels of Delta-9 unsaturated fatty acids and 1-alkyl-2,3-diacylglycerol in the Harderian gland. Required for normal production of meibum, an oily material that prevents drying of the cornea (By similarity).
messages: The histidine box domains are involved in binding the catalytic metal ions.
messages: Up-regulated in liver in the absence of dietary unsaturated fatty acids(PubMed:1982442). Expression in adipose tissue seems to be constitutive (PubMed:1982442).

10116:Gng5
gene id: 10116:Gng5
uniprot id: P63219
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units, alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

10116:Dnajb11
gene id: 10116:Dnajb11
uniprot id: Q6TUG0
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.
messages: Contains high-mannose Endo H-sensitive carbohydrates.
messages: Cys-169, Cys-171, Cys-193 and Cys-196 form intramolecular disulfide bonds. The preferential partner for each Cys is not known (By similarity).
messages: Endoplasmic reticulum lumen
messages: Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Binds to denatured substrates in an ATP-independent manner. Interacts via the J domain with HSPA5 in an ATP-dependent manner (By similarity).

10116:Or2ah1
gene id: 10116:Or2ah1
uniprot id: A0A0G2K408
uniprot id: A6HMU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Fst
gene id: 10116:Fst
uniprot id: P21674
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
messages: Monomer.
messages: Secreted

10116:LOC108349691
gene id: 10116:LOC108349691
uniprot id: A0A8I6A289
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

10116:Cblc
gene id: 10116:Cblc
uniprot id: G3V8H4
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subunit
messages: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419', has the highest ubiquitin ligase activity among CBL family proteins. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
messages: Autoubiquitinated, when phosphorylated at Tyr-341.
messages: EF-hand-like and Sh2-like domains are required for N-terminal inhibition of E3 activity.
messages: Interacts with Ubiquitin-conjugating enzyme E2 UBE2D2 and UBE2D3. Interacts with EGFR (tyrosine phosphorylated). Interacts with the SH3 domain proteins LYN and CRK. Interacts (via RING-type zinc finger) with TGFB1I1 (via LIM zinc-binding domain 2); the interaction is direct and enhances the E3 activity. Interacts directly with RET (inactive) and CD2AP; dissociates from RET upon RET activation by GDNF which also increases the interaction with CD2AP suggesting dissociation as CBLC:CD2AP complex. Interacts with SRC; the interaction is enhanced when SRC is phosphorylated at 'Tyr-419'.
messages: Phosphorylated on multiple tyrosine residues by SRC.
messages: Phosphorylation at Tyr-341 is necessary and sufficient for the activation of E3 activity.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.
messages: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
messages: This protein has one functional calcium-binding site.

10116:Tm7sf3
gene id: 10116:Tm7sf3
uniprot id: A6IN26
uniprot id: Q5FVF4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Involved in the inhibition of cytokine-induced death of pancreatic beta cells (By similarity). Involved in the promotion of insulin secretion from pancreatic beta cells (By similarity). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (By similarity).
messages: Membrane

10116:Pcyox1l
gene id: 10116:Pcyox1l
uniprot id: B5DEI0
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

10116:Calr3
gene id: 10116:Calr3
uniprot id: F7EM31
uniprot id: Q6AYG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

10116:Olr1163
gene id: 10116:Olr1163
uniprot id: D3ZZJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Krtap19-5
gene id: 10116:Krtap19-5
uniprot id: A6JLA6
uniprot id: F1LZR0
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

10116:Esrrg
gene id: 10116:Esrrg
uniprot id: A6JGU0
uniprot id: P62510
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by PCAF/KAT2 (in vitro).
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Homodimer. Interacts with NRIP1, NCOA1 and NCOR2. Binds TLE1, PNRC1 and PNRC2. Binds GRIP1 (By similarity).
messages: Nucleus
messages: Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle (By similarity).

10116:Adgrb2
gene id: 10116:Adgrb2
uniprot id: A0A0G2K6N2
uniprot id: A0A8I5ZJF8
uniprot id: A0A8I6A0N9
uniprot id: A6ISM9
uniprot id: D3ZN99
names: Subcellular Location Annotation
messages: Membrane

10116:Mak16
gene id: 10116:Mak16
uniprot id: A6IVV8
uniprot id: F7F652
names: Similarity
messages: Belongs to the MAK16 family.

10116:Adcy5
gene id: 10116:Adcy5
uniprot id: Q04400
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by forskolin. Activated by GNAS. Activity is further increased by interaction with the G protein beta and gamma subunit complex formed by GNB1 and GNG2 (By similarity). Is not activated by calmodulin. Inhibited by adenosine and ATP analogs. Inhibited by calcium ions, already at micromolar concentrations (By similarity). Phosphorylation by RAF1 results in its activation (By similarity).
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:1409703). Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion.
messages: Cell membrane
messages: Detected in brain and kidney.
messages: Interacts with GNAS, GNB1 and GNG2 (By similarity). Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2 (By similarity). Interacts with RAF1 (By similarity).
messages: Phosphorylated by RAF1.
messages: The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
messages: cilium

10116:Timm17b
gene id: 10116:Timm17b
uniprot id: A6KP64
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

10116:Pnliprp2
gene id: 10116:Pnliprp2
uniprot id: A6JI68
uniprot id: D3ZX17
uniprot id: P54318
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: By NGF (at protein level).
messages: CLPS stimulates triacylglycerol lipase activity. Triacylglycerol lipase activity is not inhibited by increasing bile salt concentration.
messages: Expressed in pancreatic acinar cells (at protein level).
messages: Lipase that primarily hydrolyzes triglycerides and galactosylglycerides (PubMed:8656075, PubMed:9822688). In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides (By similarity). Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity (PubMed:8656075). Can completely deacylate triacylglycerols (By similarity). When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase (By similarity). Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids (By similarity). Hydrolyzes medium- and long-chain fatty acyls in galactolipids (PubMed:9822688). May act together with LIPF to hydrolyze partially digested triglycerides (By similarity). Hydrolyzes long-chain monoglycerides with high efficiency. In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity). Also has low phospholipase activity (PubMed:8656075, PubMed:9822688). In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (PubMed:32963038). The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (PubMed:32963038).
messages: Secreted
messages: Zymogen granule membrane
messages: neuron projection

10116:Amigo2
gene id: 10116:Amigo2
uniprot id: Q7TNJ4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Binds itself as well as AMIGO1 and AMIGO3.
messages: Cell membrane
messages: High level expression in cerebellum of newborn rats is down-regulated to 50% by postnatal day 14.
messages: Highest levels in the lung. High levels in cerebellar granule neurons and Purkinje cells. Also in pyramidal cells between CA1 and CA3 regions of the hippocampus and granule cells of the dentate gyrus.
messages: Nucleus
messages: Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain.

10116:Eif3h
gene id: 10116:Eif3h
uniprot id: Q6P9U8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner. Interacts with DHX33; the interaction is independent of RNA (By similarity).
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

10116:Oxct2b
gene id: 10116:Oxct2b
uniprot id: Q5XIJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Expressed in flagella of epididymal sperm.
messages: Homodimer.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Probably play and important roles in the energy metabolism of spermatozoa (By similarity).
messages: Mitochondrion

10116:Nosip
gene id: 10116:Nosip
uniprot id: A6JAW4
uniprot id: D3ZH12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
messages: Nucleus

10116:Vom1r34
gene id: 10116:Vom1r34
uniprot id: A0A8I5YCE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior.

10116:Nxpe4
gene id: 10116:Nxpe4
uniprot id: Q5XI89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXPE family.
messages: Secreted

10116:Rps4y2
gene id: 10116:Rps4y2
uniprot id: A6IN57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eS4 family.
messages: nucleolus

10116:Efhc1
gene id: 10116:Efhc1
uniprot id: D3ZD71
names: Subcellular Location Annotation
messages: cilium axoneme

10116:Foxh1
gene id: 10116:Foxh1
uniprot id: A6HSC2
uniprot id: G3V7Y6
names: Subcellular Location Annotation
messages: Nucleus

10116:Med6
gene id: 10116:Med6
uniprot id: A6JDN3
uniprot id: F7FE45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

10116:Adam1a
gene id: 10116:Adam1a
uniprot id: P70505
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer with ADAM2/fertilin subunit beta.
messages: In the testis, expressed at all stages of development.
messages: May be involved in sperm-egg fusion.
messages: Membrane

10116:Insm2
gene id: 10116:Insm2
uniprot id: A6HBM5
names: Subcellular Location Annotation
messages: Nucleus

10116:Sfr1
gene id: 10116:Sfr1
uniprot id: A0A0H2UHK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

10116:Wnt8b
gene id: 10116:Wnt8b
uniprot id: A6JHG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

10116:Bloc1s3
gene id: 10116:Bloc1s3
uniprot id: D4A3V6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S3 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).
messages: Cytoplasm

10116:Sft2d3
gene id: 10116:Sft2d3
uniprot id: A6J2P5
uniprot id: D3ZV26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

10116:Tnfrsf4
gene id: 10116:Tnfrsf4
uniprot id: A6IUV2
uniprot id: P15725
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated T-cells.
messages: Interacts with TRAF2, TRAF3 and TRAF5.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity).

10116:Hyal3
gene id: 10116:Hyal3
uniprot id: A6I2Y6
uniprot id: Q76HM9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage.
messages: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro.
messages: Membrane
messages: N-glycosylated.
messages: Secreted
messages: acrosome

10116:Lgr4
gene id: 10116:Lgr4
uniprot id: Q9Z2H4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and pro-inflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP. Required for proper development of GnRH neurons (gonadotropin-releasing hormone expressing neurons) that control the release of reproductive hormones from the pituitary gland (By similarity).

10116:Slc6a17
gene id: 10116:Slc6a17
uniprot id: P31662
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Found exclusively in the central nervous system and is more abundant in the cerebellum and the cerebral cortex. Expressed in PC-12 cell line.
messages: Postsynapse
messages: Presynapse
messages: Synaptic vesicle transporter with apparent selectivity for neutral amino acids. The transport is sodium-coupled but chloride-independent, likely driven by the proton electrochemical gradient generated by vacuolar H(+)-ATPase in an overall electrogenic mechanism. May contribute to the synaptic uptake of neurotransmitter precursors in a process coupled in part to vesicle exocytosis.
messages: synaptic vesicle membrane

10116:Scamp3
gene id: 10116:Scamp3
uniprot id: A6J6C4
uniprot id: E9PTW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

10116:LOC100302465
gene id: 10116:LOC100302465
uniprot id: A0A0G2K7C9
uniprot id: B3DMA4
names: Subcellular Location Annotation
messages: centrosome

10116:Atp6v1c2
gene id: 10116:Atp6v1c2
uniprot id: Q6AYE4
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the V-ATPase C subunit family.
messages: Lung, kidney and testis. Expressed in both bronchiolar and alveolar lung epithelial cells. Isoform 1 is predominantly expressed in the lung while isoform 2 is strongly expressed in the kidney and testis.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR.

10116:E2f4
gene id: 10116:E2f4
uniprot id: A6IYN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

10116:Hnrnpu
gene id: 10116:Hnrnpu
uniprot id: Q6IMY8
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Arg-707 and Arg-713 are dimethylated, probably to asymmetric dimethylarginine (By similarity).
messages: Cell surface
messages: Chromosome
messages: Citrullinated by PADI4.
messages: Cleaved at Asp-94 by CASP3 during T-cell apoptosis, resulting in a loss of DNA- and chromatin-binding activities.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression. Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability. Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Required for the topoisomerase TOP2A protein stability and activity in a RNA-dependent manner (PubMed:20554522). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator. Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner. Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation. Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus. Negatively regulates glucocorticoid-mediated transcriptional activation. Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling. Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression. Participates in the circadian regulation of the core clock component BMAL1 transcription. Plays a role in the regulation of telomere length. Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis. Plays a role in mRNA st…
messages: Extensively phosphorylated. Phosphorylated on Ser-58 by PLK1 and dephosphorylated by protein phosphatase 2A (PP2A) in mitosis.
messages: Midbody
messages: Nucleus
messages: Nucleus matrix
messages: Nucleus speckle
messages: Oligomer (via ATPase domain and RNA-binding RGG-box region); oligomerization occurs upon ATP-binding in a chromatin-associated RNAs (caRNAs)- and transcription-dependent manner and is required for chromatin decompaction. ATP hydrolysis is required to cycle from an oligomeric to monomeric state to compact chromatin. Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Associates with heterogeneous nuclear ribonucleoprotein (hnRNP) particles. Associates (via middle region) with the C-terminal domain (CTD) RNA polymerase II (Pol II) holoenzyme; this association occurs in a RNA-independent manner. Associates (via middle region) with the core-TFIIH basal transcription factor complex; this association inhibits the CTD phosphorylation of RNA polymerase II holoenzyme by down-regulating TFIIH kinase activity. Associates with the telomerase holoenzyme complex. Associates with spindle microtubules (MTs) in a TPX2-dependent manner. Interacts (via C-terminus) with actin; this interaction is direct and mediates association with the phosphorylated CTD of RNA polymerase II and is disrupted in presence of the long non-coding H19 RNA. Interacts with AURKA. Interacts (via C-terminus) with CBX5; this interaction is, at least in part, RNA-dependent. Interacts with CR2. Interacts with CRY1. Interacts (via C-terminus) with EP300; this interaction enhances DNA-binding to nuclear scaffold/matrix attachment region (S/MAR) elements. Interacts with ERBB4. Interacts with GEMIN5. Interacts with IGF2BP1. Interacts with IGF2BP2 and IGF2BP3. Interacts with NCL; this interaction occurs during mitosis. Interacts (via C-terminus) with NR3C1 (via C-terminus). Interacts with PLK1; this interaction induces phosphorylation of HNRNPU at Ser-58 in mitosis. Interacts with POU3F4. Interacts with SMARCA4; this interacti…
messages: The SAP domain is necessary for specific binding to nuclear scaffold/matrix attachment region (S/MAR) elements in DNA. The RNA-binding RGG-box region is necessary for its association with inactive X chromosome (Xi) regions and to chromatin-associated RNAs (caRNAs). Both the DNA-binding domain SAP and the RNA-binding RGG-box region are necessary for the localization of Xist RNA on the Xi. The ATPase and RNA-binding RGG-box regions are necessary for oligomerization.
messages: centrosome
messages: kinetochore
messages: spindle
messages: spindle pole

10116:Ncor2
gene id: 10116:Ncor2
uniprot id: A0A0G2JU91
uniprot id: A6J0X3
names: Similarity
messages: Belongs to the N-CoR nuclear receptor corepressors family.

10116:Ywhaq
gene id: 10116:Ywhaq
uniprot id: A6HAW8
uniprot id: P68255
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity).
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with CDK16 (By similarity). Interacts with RGS7 (phosphorylated form). Interacts with SSH1. Interacts with CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with GAB2. Interacts with the 'Ser-241' phosphorylated form of PDPK1. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with SLITRK1 (By similarity). Interacts with RIPOR2 (By similarity). Interacts with INAVA; the interaction increases upon PRR (pattern recognition receptor) stimulation and is required for cellular signaling pathway activation and cytokine secretion (By similarity). Interacts with MARK2, MARK3 and MARK4 (By similarity). Interacts with MEFV (By similarity).

10116:Slc34a1
gene id: 10116:Slc34a1
uniprot id: A6KAT2
uniprot id: Q06496
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Interacts via its C-terminal region with NHERF4. Interacts with NHERF1. Interacts with TMEM174; regulates SLC34A1 internalization by PTH and FGF23 (By similarity).
messages: Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:8327470, PubMed:9058191, PubMed:10198426, PubMed:10370077, PubMed:10926678). The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic (PubMed:10198426).
messages: Kidney.
messages: Membrane
messages: Transport activity is significantly increased in response to dietary phosphate deprivation.
messages: Up-regulated by a low-phosphate diet (PubMed:9058191). Down-regulated by PTH at brush border membrane of proximal tubules (PubMed:8691716).

10116:Pou3f3
gene id: 10116:Pou3f3
uniprot id: Q63262
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Brain.
messages: Expressed from embryonic day 11.5 into adulthood.
messages: Homodimer.
messages: Nucleus
messages: Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity).

10116:Vom2r15
gene id: 10116:Vom2r15
uniprot id: A0A0G2K8E2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:RT1-T24-3
gene id: 10116:RT1-T24-3
uniprot id: A0A0G2K8A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Membrane

10116:Rpl13
gene id: 10116:Rpl13
uniprot id: P41123
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL13 family.
messages: Component of the 60S large ribosomal subunit (LSU).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the LSU, it is probably required for its formation and the maturation of rRNAs. Plays a role in bone development.
messages: Cytoplasm

10116:Prl4a1
gene id: 10116:Prl4a1
uniprot id: A0A0M6L0M6
uniprot id: P09320
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Expressed from days 14 to term of pregnancy.
messages: Secreted

10116:Rwdd1
gene id: 10116:Rwdd1
uniprot id: Q99ND9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RWDD1/GIR2 family.
messages: Interacts with DRG2 (By similarity). Interacts with androgen receptor.
messages: Protects DRG2 from proteolytic degradation.

10116:Plaur
gene id: 10116:Plaur
uniprot id: P49616
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA.
messages: Cell membrane
messages: GPI-anchored form.
messages: Monomer (Probable). Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with MRC2 (By similarity). Interacts with SORL1 (via N-terminal ectodomain); this interaction decreases PLAUR internalization (By similarity). The ternary complex composed of PLAUR-PLAU-SERPINE1 also interacts with SORL1 (By similarity).
messages: Secreted
messages: Up-regulated in transformed thyroid cell lines.

10116:Tll2
gene id: 10116:Tll2
uniprot id: F1M280
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Cxcr3
gene id: 10116:Cxcr3
uniprot id: A6IQC9
uniprot id: Q9JII9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homomer. Forms heteromers with ACKR4 (By similarity).
messages: Homomer. Forms heteromers with ACKR4.
messages: Membrane
messages: N-glycosylated.
messages: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity).
messages: Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding.

10116:Or5aq6
gene id: 10116:Or5aq6
uniprot id: A6HMY6
uniprot id: D3ZQW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Nfatc4
gene id: 10116:Nfatc4
uniprot id: D3Z9H7
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:12370307). Along with NFATC3, involved in embryonic heart development. Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function. Transactivates many genes involved in heart physiology. Along with GATA4, binds to and activates NPPB/BNP promoter (PubMed:9568714). Activates NPPA/ANP/ANF and MYH7/beta-MHC transcription (PubMed:19026640). Binds to and transactivates AGTR2 gene promoter. Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation. In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during a developmental critical period when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP). Plays a role in adipocyte differentiation. May be involved in myoblast differentiation into myotubes (By similarity). Binds the consensus DNA sequence 5'-GGAAAAT-3' (By similarity). In the presence of CREBBP, activates TNF transcription. Binds to PPARG gene promoter and regulates its activity (By similarity). Binds to PPARG and REG3G gene promoters (By similarity).
messages: Cytoplasm
messages: Expressed in heart (at protein level).
messages: Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other NFAT proteins, such as NFATC4, NFATC3, or members of the activating protein-1 (AP-1) family and MAF can also bind the complex. NFAT proteins can bind DNA as monomers or dimers. Interacts with CREBBP; this interaction potentiates transcription activation (By similarity). Interacts with MAPK8/JNK1 and MAPK9/JNK2 (By similarity). Interacts with GATA4 (via the second Zn finger) (By similarity). Interacts (via N-terminus) with IRAK1 (via C-terminus). Interacts with RPS6KA3. Interacts with HOMER1, HOMER2 and HOMER3; this interaction competes with calcineurin/PPP3CA-binding and hence prevents NFATC4 dephosphorylation and activation (By similarity). Interacts with ESR1 and ESR2; this interaction decreases NFATC4 transcriptional activity. Interacts with MTOR and MAPK7/ERK5 (By similarity). Interacts with TRIM17; this interaction prevents NFATC3 nuclear localization (By similarity).
messages: Nucleus
messages: Phosphorylated by NFATC-kinases; dephosphorylated by calcineurin/PPP3CA. Phosphorylated on Ser-168 and Ser-170 by MTOR, IRAK1, MAPK7/ERK5 and MAPK14/p38, on Ser-213 and Ser-217 by MAPK8 and MAPK9, and on Ser-289 and Ser-344 by RPS6KA3 (By similarity). Phosphorylated by GSK3B; this phosphorylation markedly increases NFATC4 ubiquitination (PubMed:19026640). Phosphorylation by MAPK8/JNK1, MAPK9/JNK2 and RPS6KA3 may stimulate NFATC4 transcriptional activity. Phosphorylation at Ser-168 and Ser-170 is stimulated by UV irradiation (By similarity).
messages: Rel similarity domain (RSD) or Rel homology domain (RHD) allows DNA-binding and cooperative interactions with AP-1 factors.
messages: Ubiquitinated, leading to degradation by the proteasome. Ubiquitination may be stimulated by GSK3B-dependent phosphorylation. Polyubiquitin linkage mainly occurs through 'Lys-48'.

10116:Amz1
gene id: 10116:Amz1
uniprot id: Q400C9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Probable zinc metalloprotease.

10116:Slc6a14
gene id: 10116:Slc6a14
uniprot id: Q334I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

10116:Me3
gene id: 10116:Me3
uniprot id: A0A0G2K4C6
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

10116:Mvk
gene id: 10116:Mvk
uniprot id: A6J1Z8
uniprot id: P17256
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
messages: Cytoplasm
messages: Farnesyl pyrophosphate and geranyl pyrophosphate inhibit mevalonate kinase activity by binding competitively at the ATP-binding sites.
messages: Homodimer.
messages: Peroxisome
messages: The authors of PubMed:14730012 identify two forms of Mvk in rat liver, one form localizes to the cytosol and the other form to the peroxisome, whereas according to the authors of PubMed:14730012 the protein is found only in the cytoplasm with no evidence for its peroxisomal localization.

10116:Esrp2
gene id: 10116:Esrp2
uniprot id: B2RYJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Nucleus
messages: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity).

10116:Alad
gene id: 10116:Alad
uniprot id: A6J7V5
uniprot id: P06214
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Binds 8 zinc ions per octamer. Requires four zinc ions per octamer for full catalytic activity. Can bind up to 2 zinc ions per subunit.
messages: Can alternate between a fully active homooctamer and a low-activity homohexamer. A bound magnesium ion may promote the assembly of the fully active homooctamer. The magnesium-binding site is absent in the low-activity homohexamer. Inhibited by compounds that favor the hexameric state. Inhibited by divalent lead ions. The lead ions partially displace the zinc cofactor (By similarity).
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer; active form. Homohexamer; low activity form (By similarity).
messages: Homooctamer; active form. Homohexamer; low activity form.

10116:Kti12
gene id: 10116:Kti12
uniprot id: Q5I0L7
names: Similarity
messages: Belongs to the KTI12 family.

10116:Ubp1
gene id: 10116:Ubp1
uniprot id: D4A030
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

10116:Ndufa10
gene id: 10116:Ndufa10
uniprot id: A0A8I6A6A5
uniprot id: A6JQU0
uniprot id: A6JQU2
uniprot id: Q561S0
uniprot id: Q6P6W6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Binds 1 FAD per subunit.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Expressed in the head and flagellum of epididymal sperm but not in testicular sperm (at protein level).
messages: Mitochondrion matrix
messages: Phosphorylation at Ser-250 by PINK1 is required for the binding and/or reduction of the complex I substrate ubiquinone.

10116:Svs3a
gene id: 10116:Svs3a
uniprot id: A0A8I5ZJQ1
uniprot id: Q7TQ59
names: Similarity
messages: Belongs to the semenogelin family.

10116:Mturn
gene id: 10116:Mturn
uniprot id: A0A8I6ARQ2
uniprot id: Q5XI20
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTURN family.
messages: Cytoplasm
messages: Phosphorylation at Tyr-34 is essential for its ability to promote megakaryocyte differentiation.
messages: Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression (By similarity). Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser- 536' (By similarity). May be involved in early neuronal development (By similarity).

10116:Trpm2
gene id: 10116:Trpm2
uniprot id: E9PTA2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.
messages: Cell membrane
messages: Cell projection
messages: Cytoplasmic vesicle
messages: Detected in pancreas beta-cells (PubMed:16601673). Detected in fetal brain cortex neurons (at protein level) (PubMed:16651700).
messages: Homotetramer.
messages: Lysosome
messages: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:16651700, PubMed:16260005, PubMed:11804595, PubMed:16601673, PubMed:19454650). Functions as ligand-gated ion channel. Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. Extracellular calcium passes through the channel and increases channel activity (By similarity). Also contributes to Ca(2+) release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels (PubMed:25562606). Activated by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Activated by intracellular ADP-ribose, beta-NAD (NAD(+)) and similar compounds, and by oxidative stress caused by reactive oxygen or nitrogen species (PubMed:16260005, PubMed:16601673, PubMed:25562606). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate. Activation by ADP-ribose and beta-NAD is strongly increased by moderate heat (35 to 40 degrees Celsius) (By similarity). Likewise, reactive oxygen species lower the threshold for activation by moderate heat (37 degrees Celsius). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels (PubMed:16601673). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in …
messages: Perikaryon
messages: The cytosolic nudix box binds ADP-ribose and is required for channel activation by ADP-ribose.

10116:Lpcat2b
gene id: 10116:Lpcat2b
uniprot id: A6KPJ5
uniprot id: Q4V8A1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Membrane
messages: Probable acetyltransferase.
messages: The HXXXXD motif is essential for acyltransferase activity.

10116:RGD1566137
gene id: 10116:RGD1566137
uniprot id: A0A8I5ZVS9
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

10116:Ube3d
gene id: 10116:Ube3d
uniprot id: Q3T1H6
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: Interacts with UBE2C/UbcH10 (E2 ubiquitin-conjugating enzyme).
messages: The C-terminal half (AA 167-370) is able to bind cyclin-B and shows a self-ubiquitination activity (mono-, poly, or multi-ubiquitination) in a HECT-like sequence dependent manner.
messages: Ubiquitinated by UBCH10 (E2 ubiquitin-conjugating enzyme).

10116:Mos
gene id: 10116:Mos
uniprot id: A6JFL8
uniprot id: M0R4F9
names: Similarity
messages: Belongs to the protein kinase superfamily.

10116:Ap1s1
gene id: 10116:Ap1s1
uniprot id: A0A8I5ZW78
uniprot id: A0A8I6ASY6
uniprot id: A6J050
uniprot id: B5DFI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Membrane
messages: clathrin-coated pit

10116:Abhd17c
gene id: 10116:Abhd17c
uniprot id: B5DFK7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the AB hydrolase superfamily. ABHD17 family.
messages: Expressed in brain (at protein level).
messages: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95.
messages: Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization. Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95.
messages: Postsynaptic density membrane
messages: Recycling endosome membrane
messages: dendritic spine

10116:Anks1a
gene id: 10116:Anks1a
uniprot id: A0A0G2K2G7
uniprot id: A0A8I6AJG9
uniprot id: A6JJP3
names: Subcellular Location Annotation
messages: Cytoplasm

10116:Rbm42
gene id: 10116:Rbm42
uniprot id: A0A0G2JXM6
uniprot id: Q6AXT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM RBM42 family.
messages: Binds (via the RRM domain) to the 3' untranslated region (UTR) of p21 mRNA.
messages: Cytoplasm
messages: Interacts with HNRNPK.
messages: Nucleus

10116:Notch4
gene id: 10116:Notch4
uniprot id: A6KTE6
uniprot id: F7EQS6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

10116:Nkain3
gene id: 10116:Nkain3
uniprot id: A6IID7
uniprot id: F1LV86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

10116:Rpl27a
gene id: 10116:Rpl27a
uniprot id: A6I7W7
uniprot id: P18445
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Hydroxylated on His-39 by MINA.

10116:Aldh3a1
gene id: 10116:Aldh3a1
uniprot id: A6HF73
uniprot id: P11883
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:2831537). Preferentially oxidizes aromatic aldehyde substrates (PubMed:2831537). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
messages: Belongs to the aldehyde dehydrogenase family.
messages: Cytoplasm
messages: Homodimer.
messages: This protein can be induced by a number of chemical carcinogens during rat hepatocarcinogenesis.

10116:Bop1
gene id: 10116:Bop1
uniprot id: Q562C2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat BOP1/ERB1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome. The PeBoW complex associates with DDX27, BOP1 interacts directly with DDX27.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

10116:Zfp382
gene id: 10116:Zfp382
uniprot id: A0JPL0
names: Function
names: Induction
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Contaminating sequence. Sequence of unknown origin in the C-terminal part.
messages: Functions as a sequence-specific transcriptional repressor.
messages: Interacts with TRIM28; enhances the transcriptional repressor activity.
messages: Nucleus
messages: Ubiquitously expressed with higher expression in lung, kidney and testis.
messages: Up-regulated by EGF; delayed early response target for EGF (at protein level).

10116:Brsk1
gene id: 10116:Brsk1
uniprot id: B2DD29
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by phosphorylation on Thr-189 by STK11/LKB1.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cytoplasm
messages: Mainly present in brain. Present in presynaptic nerve terminals (at protein level).
messages: Nucleus
messages: Phosphorylated at Thr-189 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not phosphorylated at Thr-189 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated via dephosphorylation of Thr-189 by PP2C. May be autophosphorylated.
messages: Presynaptic active zone
messages: Protein synthesis is inhibited by the TSC1-TSC2 complex acting through TORC1 in neurons, leading to regulate neuron polarization.
messages: Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-523' and 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C (By similarity). In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1.
messages: Synapse
messages: centrosome
messages: synaptic vesicle

10116:Kif18a
gene id: 10116:Kif18a
uniprot id: A6HNZ9
uniprot id: D3ZIA5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

10116:Tssk4
gene id: 10116:Tssk4
uniprot id: A6KH28
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

10116:Lyrm7
gene id: 10116:Lyrm7
uniprot id: B4F7A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane (By similarity).
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

10116:Nhs
gene id: 10116:Nhs
uniprot id: A0A0G2JXJ0
uniprot id: F1LU76
names: Similarity
messages: Belongs to the NHS family.

10116:Hsd11b2
gene id: 10116:Hsd11b2
uniprot id: P50233
names: Activity Regulation
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as corticosterone, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as 11-dehydrocorticosterone, in the presence of NAD(+) (PubMed:7649078). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids (PubMed:7649078, PubMed:34028587). Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure (PubMed:34028587). Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen (By similarity). Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone (By similarity). Converts 7-beta-25-dihydroxycholesterol to 7-oxo-25-hydroxycholesterol in vitro (By similarity). 7-beta-25-dihydroxycholesterol (not 7-oxo-25-hydroxycholesterol) acts as ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (By similarity).
messages: Endoplasmic reticulum
messages: Highly expressed in kidney, adrenal gland and distal colon, and at much lower levels in lung, hypothalamus, hippocampus, and midbrain.
messages: Homozygous knockout pups have reduced Na(+) and water content in the skin at birth, but retain higher levels of Na(+) and water in the skin throughout development and into adulthood at the expense of K(+), manifesting hypokalaemia by 15 days of age and contributing to salt sensitive hypertension.
messages: Inhibited by glycyrrhetinic acid (By similarity). Induced by progesterone, through the Ihh signaling pathway (By similarity).
messages: Interacts with ligand-free cytoplasmic NR3C2.
messages: Microsome
messages: Rats and mice do not produce appreciable cortisol, because they do not express the 17-alpha hydroxylase (Cyp17a1) enzyme in the adrenals.

10116:Rad50
gene id: 10116:Rad50
uniprot id: Q9JIL8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Chromosome
messages: Component of the MRN complex composed of two heterodimers RAD50/MRE11 associated with a single NBN. As part of the MRN complex, interacts with MCM8 and MCM9; the interaction recruits the complex to DNA repair sites. Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11 and NBN. Found in a complex with TERF2. Interacts with RINT1. Interacts with BRCA1 via its N-terminal domain. Interacts with DCLRE1C/Artemis. Interacts with MRNIP (By similarity). Interacts with CYREN (via XLF motif) (By similarity).
messages: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity).
messages: Nucleus
messages: Present at low levels in the heart at fetal-day 17, at relatively constant levels at postnatal days 10, 17 and 21 and at slightly lower levels in the adult heart. Detected in liver, kidney and lung. Barely detectable in skeletal muscle with slightly higher levels observed in brain and the ventricles of the heart (at protein level).
messages: The zinc-hook, which separates the large intramolecular coiled coil regions, contains 2 Cys residues that coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another RAD50 molecule, thereby forming a V-shaped homodimer. The two heads of the homodimer, which constitute the ATP-binding domain, interact with the MRE11 homodimer (By similarity).
messages: telomere

10116:Gabarap
gene id: 10116:Gabarap
uniprot id: A6HFZ8
uniprot id: P60517
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ATG8 family.
messages: Cytoplasmic vesicle
messages: Endomembrane system
messages: Expressed in brain (at protein level) (PubMed:25172774). Can be found in both somatodendritic and axonal compartment of neurons (PubMed:11461150).
messages: Golgi apparatus membrane
messages: Interacts with GPHN and NSF (PubMed:10900017, PubMed:11461150). Interacts with ATG3, ATG7 and ATG13 (By similarity). Interacts with alpha-tubulin (By similarity). Interacts with beta-tubulin (PubMed:10899939). Interacts with GABRG2 (By similarity). Interacts with RB1CC1 (By similarity). Interacts with ULK1 (By similarity). Interacts with CALR (By similarity). Interacts with DDX47 (By similarity). Interacts with TP53INP1 and TP53INP2 (By similarity). Interacts with TBC1D5 (By similarity). Interacts with TBC1D25 (By similarity). Directly interacts with SQSTM1 (By similarity). Interacts with MAPK15 (By similarity). Interacts with TECPR2 (By similarity). Interacts with PCM1 (By similarity). Interacts with TRIM5 and TRIM21 (By similarity). Interacts with MEFV (By similarity). Interacts with KIF21B (PubMed:25172774). Interacts with WDFY3; this interaction is required for WDFY3 recruitment to MAP1LC3B-positive p62/SQSTM1 bodies (By similarity). Interacts with FLCN; interaction regulates autophagy (By similarity). Interacts with UBA5 (By similarity). Interacts with KBTBD6 and KBTBD7; the interaction is direct and required for the ubiquitination of TIAM1 (By similarity). Interacts with reticulophagy regulators RETREG1, RETREG2 and RETREG3 (By similarity). Interacts with IRGM (By similarity). Interacts with STX17 (By similarity). Interacts with CT55; this interaction may be important for GABARAP protein stability (By similarity).
messages: The precursor molecule is cleaved by ATG4 (ATG4A, ATG4B, ATG4C or ATG4D) to expose the glycine at the C-terminus and form the cytosolic form, GABARAP-I. The processed form is then activated by APG7L/ATG7, transferred to ATG3 and conjugated to phosphatidylethanolamine (PE) phospholipid to form the membrane-bound form, GABARAP-II. During non-canonical autophagy, the processed form is conjugated to phosphatidylserine (PS) phospholipid. ATG4 proteins also mediate the delipidation of PE-conjugated forms. In addition, ATG4B and ATG4D mediate delipidation of ATG8 proteins conjugated to PS during non-canonical autophagy. ATG4B constitutes the major protein for proteolytic activation (By similarity). ATG4D is the main enzyme for delipidation activity (By similarity).
messages: Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton (PubMed:11461150). Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (By similarity). Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination a nd degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction. Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation (By similarity). Involved in apoptosis (By similarity).
messages: autophagosome membrane
messages: cytoskeleton

10116:Rce1
gene id: 10116:Rce1
uniprot id: A6HYY1
uniprot id: A6HYY2
uniprot id: B0BMW8
uniprot id: Q5M955
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Deubiquitination by USP17L2/USP17 negatively regulates the proteolytic activity toward Ras GTPases.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (By similarity).
messages: Ubiquitinated. Undergoes 'Lys-48'- and 'Lys-63'-linked ubiquitination. 'Lys-48' ubiquitination induces its degradation. Deubiquitinated by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains (By similarity).

10116:Iyd
gene id: 10116:Iyd
uniprot id: A6KIK2
uniprot id: Q5BK17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nitroreductase family.
messages: Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine. During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT). The scavanged iodide can then reenter the hormone-producing pathways. Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Homodimer.

10116:Sec31b
gene id: 10116:Sec31b
uniprot id: D4ADQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane

10116:Cemip
gene id: 10116:Cemip
uniprot id: D3ZWI0
names: Similarity
messages: Belongs to the CEMIP family.

10116:Tubb4b
gene id: 10116:Tubb4b
uniprot id: Q6P9T8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility.
messages: The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.
messages: The highly acidic C-terminal region may bind cations such as calcium.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

10116:Il34
gene id: 10116:Il34
uniprot id: Q4KM46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-34 family.
messages: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity).
messages: Homodimer. Interacts with CSF1R (By similarity).
messages: Secreted

10116:Brms1l
gene id: 10116:Brms1l
uniprot id: A6HBN0
uniprot id: B1WC78
uniprot id: D3Z9D3
names: Subcellular Location Annotation
messages: Nucleus

10116:Tcirg1
gene id: 10116:Tcirg1
uniprot id: A6HYM9
uniprot id: Q2I6B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

10116:Cxcl11
gene id: 10116:Cxcl11
uniprot id: B5DEM2
uniprot id: Q7TNL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

10116:Ddost
gene id: 10116:Ddost
uniprot id: Q641Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex (By similarity). OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (By similarity). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with SMIM22 (By similarity).
messages: Endoplasmic reticulum membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity).

10116:Cox17
gene id: 10116:Cox17
uniprot id: Q76MV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

10116:Tulp4
gene id: 10116:Tulp4
uniprot id: A6KP05
uniprot id: D3ZFM2
names: Similarity
messages: Belongs to the TUB family.

10116:Acy1
gene id: 10116:Acy1
uniprot id: Q6AYS7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M20A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).
messages: The N-terminus is blocked.

10116:Glra2
gene id: 10116:Glra2
uniprot id: A0A0G2JSH7
uniprot id: A0A8I6GJI2
uniprot id: A6K2J6
uniprot id: P22771
names: Activity Regulation
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA2 sub-subfamily.
messages: Cell membrane
messages: Cell projection
messages: Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine (PubMed:2176511). Plays a role in synaptic plasticity. Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability. Plays a role in cellular responses to ethanol.
messages: Homopentamer (in vitro). Interacts with GLRB. Heteropentamer composed of GLRA2 and GLRB. Both homopentamers and heteropentamers form functional ion channels, but their characteristics are subtly different.
messages: Identical to the human subunit alpha-2, except for 5 substitutions at positions 18, 24, 37, 194 and 404. Substitution at position 194 (G -> E) accounts for the lower strychnine sensitivity observed in neonatal rats.
messages: Inhibited by strychnine.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: The alpha subunit binds strychnine.
messages: The alpha-2* subunit isoform is present in neonatal rats, but not in older animals (PubMed:2176511, PubMed:1707830). Isoform Alpha-2* and isoform Alpha-2B are detected in embryonic and neonatal brain. At later postnatal stages, isoform Alpha-2* levels greatly decrease while isoform Alpha-2B is barely detectable (PubMed:1645300).

10116:Cdca8
gene id: 10116:Cdca8
uniprot id: Q6AXW0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the borealin family.
messages: Citrullinated by PADI4.
messages: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity).
messages: Cytoplasm
messages: May form homooligomers and homodimers. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and BIRC5. Interacts with SENP3, UBE2I and RANBP2. Interacts (phosphorylated) with SGO1 and SGO2; the association is dependent on CDK1 (By similarity).
messages: Phosphorylated by TTK, essentially at Thr-88 and Thr-94. Phosphorylation (probably by CDK1) promotes targeting of the CPC to centromeric DNA.
messages: Sumoylated by UBE2I and RANBP2. Desumoylated by SENP3 through the removal of SUMO2 and SUMO3 (By similarity).
messages: The C-terminal region (aa 215-288) represents the dimerization motif.
messages: centromere
messages: nucleolus
messages: spindle

10116:Babam1
gene id: 10116:Babam1
uniprot id: A6K9T3
uniprot id: Q5XIJ6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM1 family.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex.
messages: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination.
messages: Cytoplasm
messages: Nucleus
messages: The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes.

10116:Hax1
gene id: 10116:Hax1
uniprot id: A6J6I5
uniprot id: Q7TSE9
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in hindlimb and cardiac muscles throughout embryogenesis (at protein level).
messages: Belongs to the HAX1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Interacts with ABCB1, ABCB4 and ABCB11 (PubMed:15159385). Directly associates with HCLS1/HS1, through binding to its N-terminal region (By similarity). Interacts with CTTN (PubMed:15159385). Interacts with PKD2. Interacts with GNA13. Interacts with CASP9. Interacts with ITGB6. Interacts with PLN and ATP2A2; these interactions are inhibited by calcium. Interacts with GRB7. Interacts (via C-terminus) with XIAP/BIRC4 (via BIR 2 domain and BIR 3 domain) and this interaction blocks ubiquitination of XIAP/BIRC4. Interacts with TPC2. Interacts with KCNC3. Interacts with XPO1 (By similarity). Interacts with RNF217 (By similarity). Interacts with UCP3; the interaction is direct and calcium-dependent (By similarity).
messages: Mitochondrion matrix
messages: Nucleus
messages: Nucleus membrane
messages: P-body
messages: Present in striated muscles (at protein level).
messages: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.
messages: Sarcoplasmic reticulum
messages: cell cortex

10116:Tpcn1
gene id: 10116:Tpcn1
uniprot id: Q9WTN5
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.
messages: Dimer. Interacts with MTOR; the interaction is required for TPCN1 ATP sensitivity (By similarity). Interacts with STX7, STX8 and STX12 (By similarity). Interacts with JPT2 (By similarity). Found in a complex with LSM12, TPCN1 and TPCN2 (By similarity).
messages: Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
messages: Early endosome membrane
messages: Endosome membrane
messages: Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles. Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis. Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2. Required for mTOR-dependent nutrient sensing.
messages: Lysosome membrane
messages: N-glycosylated.
messages: Na(+) current is inhibited by ATP in a MTORC-dependent manner. ATP sensitivity is independent of PI(3,5)P2 (By similarity). Probably regulated by Mg(2+) ions, cytosolic Mg(2+) selectively inhibits outward current while lysosomal Mg(2+) modestly inhibits both the outward and inward currents. In the absence of Mg(2+), NAADP readily activates TPCN2, with properties similar to PI(3,5)P2 (By similarity). Both current elicited by PI(3,5)P2 as well as NAADP are inhibited by tetrandrine (By similarity).
messages: Recycling endosome membrane
messages: Widely expressed. Expressed at relatively high level in kidney, liver and lung, and in the kidney it is expressed at inner medullary collecting ducts.

10116:Zfp689
gene id: 10116:Zfp689
uniprot id: Q99PJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

10116:Kcnj16
gene id: 10116:Kcnj16
uniprot id: A0A8I5ZPC6
uniprot id: Q68G21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

10116:Or5b96
gene id: 10116:Or5b96
uniprot id: A6I0F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:H3f4
gene id: 10116:H3f4
uniprot id: A6HEW6
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

10116:LOC681544
gene id: 10116:LOC681544
uniprot id: Q99PS8
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in liver, blood plasma, serum and in platelets. Also present in fibrin clots, wound fluid from acute wounds and chronic leg ulcers.
messages: Interacts with THBS1 (via the TSP type I repeats); the interaction blocks the antiangiogenic effect of THBS1 with CD36. Interacts with HPSE; the interaction is enhanced at acidic pH, partially inhibits binding of HPSE to cell surface receptors and modulates its enzymatic activity. Interacts (via the HRR domain) with TMP1; the interaction partially mediates the antiangiogenic properties of HRG. Interacts with kappa and lambda light chains of IgG molecules. Interacts with ATP5F1A; the interaction occurs on the surface of T-cells and alters their cell morphology in concert with CONA. Binds IgG molecules containing kappa and lambda light chains and inhibits the formation of insoluble immunoglobulin complexes. Interacts with F12; the interaction, which is enhanced in the presence of zinc ions and inhibited by heparin-binding to HRG, inhibits factor XII autoactivation and contact-initiated coagulation (By similarity). Interacts with PLG (via its Kringle domains); the interaction tethers PLG to the cell surface and enhances its activation. Interacts (via the HRR domain) with TPM1; the interaction appears to contribute to the antiangiogenic properties of the HRR domain. Interacts with THBS2; the interaction blocks the antiangiogenic effect of THBS2 with CD36 (By similarity).
messages: N-glycosylated.
messages: Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Inhibits rosette formation. Acts as an adapter protein and implicated in regulating many processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2 (By similarity).
messages: Proteolytic cleavage produces several HRG fragments which are mostly disulfide-linked and, therefore, not released. Cleavage by plasmin is inhibited in the presence of heparin, zinc ions or in an acidic environment. Cleavage reduces binding of HRG to heparan sulfate, but enhances the ability of HRG to bind and tether plasminogen to the cell surface. On platelet activation, releases a 33 kDa antiangiogenic peptide which encompasses the HRR. Also cleaved in the C-terminal by plasmin (By similarity).
messages: Secreted
messages: The His-rich (HRR) region contains approximately 12 tandem internal repeats of the 5-residue G[H/P][H/P]PH consensus sequence. HRR binds heparan sulfate and possesses antiangiogenic, antibacterial and antifungal properties through binding Candida cells, and preferentially lysing the ergosterol-containing liposomes at low pH. The tandem repeats also bind divalent metal ions and heme (By similarity).
messages: The cystatin domains can also bind heparan sulfate. Binding is enhanced in the presence of zinc ions (By similarity).

10116:Naa35
gene id: 10116:Naa35
uniprot id: A6KAI2
uniprot id: Q6DKG0
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm
messages: Expressed in primary spermatocytes, basal epidermis, interstitial fibroblasts of skeletal muscle, and intestinal crypts.
messages: In carotid arteries, after mechanic injury.
messages: Widely expressed in the embryo. Expressed in embryonic aorta and pulmonary arteries from 12 dpc to 19 dpc.

10116:Gmppb
gene id: 10116:Gmppb
uniprot id: A6I329
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

10116:Gdpd5
gene id: 10116:Gdpd5
uniprot id: A0A8I6GK08
uniprot id: A6I6H1
uniprot id: G3V9L7
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

10116:Mpp5
gene id: 10116:Mpp5
uniprot id: B4F7E7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Endomembrane system
messages: Golgi apparatus
messages: Heterodimer with MPP1 (By similarity). Forms a heterotrimeric complex composed of PALS1, LIN7B and PATJ; the N-terminal L27 domain of PALS1 interacts with the L27 domain of PATJ and the C-terminal L27 domain of PALS1 interacts with the L27 domain of LIN7B (By similarity). Component of a complex composed of PALS1, CRB1 and MPP4 (By similarity). Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3 (By similarity). Component of a complex composed of PALS1, CRB1 and EPB41L5. Within the complex, interacts (via HOOK domain) with EPB41L5 (via FERM domain), and interacts with CRB1 (via intracellular domain) (By similarity). Component of a complex composed of PALS1, MPP3 and CRB1; PALS1 acts as a bridging protein between MPP3 (via guanylate kinase-like domain) and CRB1 (By similarity). Component of a complex composed of CRB3, PALS1 and PATJ (By similarity). Interacts (via PDZ domain) with PATJ (via N-terminus). Interacts with EZR (By similarity). Interacts (via PDZ domain) with CRB1 (via C-terminal ERLI motif) (By similarity). While the PDZ domain is sufficient for interaction with CRB1, the adjacent SH3 and guanylate kinase-like domains are likely to contribute to a high affinity interaction (By similarity). Interacts with WWTR1/TAZ (via WW domain) (By similarity). Interacts with MPP7 (By similarity). Interacts (via PDZ domain) with CRB3 (via C-terminus) (By similarity). Interacts with LIN7C. Interacts with MPDZ. Interacts with PARD6B. Interacts with SC6A1. Interacts with CDH5; the interaction promotes PALS1 localization to cell junctions and is required for CDH5-mediated vascular lumen formation and endothelial cell (By similarity). Interacts with NPHP1 (via coiled coil and SH3 domains) (By similarity). Interacts with NPHP4 (By similarity). Interacts with CRB2 (By similarity).
messages: Perikaryon
messages: Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). May play a role in the T-cell receptor-mediated activation of NF-kappa-B (By similarity). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (PubMed:20237282). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity).
messages: The L27 domain 1 functions in targeting to the tight junctions by binding to and stabilizing PATJ.
messages: The PDZ domain binds to the C-terminus of SC6A1.
messages: adherens junction
messages: axon
messages: tight junction

10116:Prpf6
gene id: 10116:Prpf6
uniprot id: A1A5S1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Identified in the spliceosome B complex. Identified in the spliceosome C complex. Associates with the U5 snRNP particle. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, LSm proteins LSm2-8 and Sm proteins. Interacts with ARAF1. Interacts with AR and NR3C1, but not ESR1, independently of the presence of hormones. Interacts with USH1G.
messages: Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.
messages: Nucleus speckle
messages: nucleoplasm

10116:Lyzl6
gene id: 10116:Lyzl6
uniprot id: A0A077S6M4
uniprot id: A0A9K3Y7P2
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

10116:Dynlt1
gene id: 10116:Dynlt1
uniprot id: B2RYR9
uniprot id: Q9Z336
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. May also be a accessory component of axonemal dynein (By similarity).
messages: Belongs to the dynein light chain Tctex-type family.
messages: Cytoplasm
messages: Golgi apparatus
messages: Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and dynein LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with RHO. Interacts with DYNC1I1 and DYNC1I2 (By similarity). Interacts with DOC2A, DOC2B and SCN10A. Interacts with PVR. Interacts with SVIL isoform 2 (By similarity). Interacts with GNB1; the interaction occurs in presence of guanine nucleotide-binding protein G(T) subunit gamma; the interaction diminishes the association of DYNLT1 with dynein IC (DYNC1I1 or DYNC1I2). Interacts with GNB2, GNB3 and GNB5; the interactions occur in presence of guanine nucleotide-binding protein G(T) subunit gamma. Interacts with ACVR2B and ARHGEF2 (By similarity). Interacts with DNAI4 (By similarity).
messages: Phosphorylated by BMPR2. The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release.
messages: Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. Required for neurite outgrowth. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling (By similarity). Involved in the regulation of mitotic spindle orientation.
messages: spindle

10116:Bnip3
gene id: 10116:Bnip3
uniprot id: F7FHM5
uniprot id: Q9ET45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

10116:Nolc1
gene id: 10116:Nolc1
uniprot id: P41777
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOLC1 family.
messages: Cytoplasm
messages: Interacts with RNA polymerase I 194 kDa subunit (RPA194) and with casein kinase-II (By similarity). Interacts with DKC1/NAP57, NOP58 and fibrillarin (PubMed:10679015).
messages: Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities.
messages: Pyrophosphorylated by 5-diphosphoinositol pentakisphosphate (5-IP7). Serine pyrophosphorylation is achieved by Mg(2+)-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue.
messages: Ubiquitinated. Monoubiquitination by the BCR(KBTBD8) complex promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
messages: Undergoes rapid and massive phosphorylation/dephosphorylation cycles on CK2 and PKC sites. NOLC1 is one of the mostly phosphorylated proteins in the cell.
messages: nucleolus

10116:Or5b95
gene id: 10116:Or5b95
uniprot id: A6I0E5
uniprot id: D4A4W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Trh
gene id: 10116:Trh
uniprot id: B1WBP2
uniprot id: P01150
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
messages: Secreted

10116:Nucks1
gene id: 10116:Nucks1
uniprot id: Q9EPJ0
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1.
messages: Chromosome
messages: Does not interact with RAD51.
messages: Nucleus
messages: Phosphorylated in an ATM-dependent manner in response to DNA damage. Phosphorylated by CDK1 and casein kinase.

10116:Sycp3
gene id: 10116:Sycp3
uniprot id: Q63520
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the XLR/SYCP3 family.
messages: Chromosome
messages: Component of the lateral elements of synaptonemal complexes (PubMed:8289794, PubMed:9933407). Homotetramer; the tetrameric helix bundles assemble end to end into long homopolimeric fibers (in vitro) (By similarity). Homooligomer that assembles into fibers; the fibers exhibit a transversal striation with a periodicity of about 20 nm (in vitro) (PubMed:9679134, PubMed:18391527). Interacts with SYCP2 (PubMed:10652260). Forms a complex with EWSR1, PRDM9, REC8 and SYCP1; complex formation is dependent of phosphorylated form of REC8 and requires PRDM9 bound to hotspot DNA; EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity).
messages: Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:8289794, PubMed:9933407). Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2.
messages: Composed of a long central coiled coil domain. The N-terminal and C-terminal regions interact with DNA.
messages: Detected in spermatocytes and testis (at protein level) (PubMed:8289794, PubMed:9933407). Testis-specific (PubMed:8289794).
messages: Nucleus
messages: Phosphorylated.
messages: centromere

10116:Kif18b
gene id: 10116:Kif18b
uniprot id: Q4KLL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Cytoplasm
messages: In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules (By similarity).
messages: Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends. Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. KIF2C phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.
messages: Nucleus
messages: cytoskeleton

10116:Esco2
gene id: 10116:Esco2
uniprot id: A0A096MJS9
uniprot id: A6K6K6
names: Subcellular Location Annotation
messages: Nucleus

10116:Or2d36
gene id: 10116:Or2d36
uniprot id: A6I7R2
uniprot id: D3ZN10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Rapsn
gene id: 10116:Rapsn
uniprot id: A6HN99
uniprot id: D3ZPG2
names: Similarity
messages: Belongs to the RAPsyn family.

10116:Or2d2
gene id: 10116:Or2d2
uniprot id: D4A0B9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Gpr35
gene id: 10116:Gpr35
uniprot id: A6JQX2
uniprot id: G3V962
uniprot id: Q33BM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

10116:Or5w20
gene id: 10116:Or5w20
uniprot id: A6HN07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Gpm6a
gene id: 10116:Gpm6a
uniprot id: Q812E9
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the myelin proteolipid protein family.
messages: Cell membrane
messages: Down-regulated by chronic stress in dentate gyrus granule neurons and CA3 pyramidal neurons.
messages: Expressed in hippocampus (at protein level). Isoform 1 is the predominant isoform expressed in brain, specifically in hippocampus. Isoform 2 is expressed at low levels in brain and kidney.
messages: Interacts with OPRM1 (PubMed:17548356). Interacts with palmitoyltransferase ZDHHC17/HIP14; the interaction leads to palmitoylation of GPM6A (By similarity).
messages: Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells (By similarity). Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. Gpm6a-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.
messages: N-glycosylated.
messages: Palmitoylated by ZDHHC17/HIP14.
messages: Up-regulated in the medial prefrontal cortex.
messages: axon
messages: dendritic spine
messages: filopodium
messages: growth cone
messages: neuron projection

10116:Rrm1
gene id: 10116:Rrm1
uniprot id: M0R486
uniprot id: Q5U2Q5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

10116:Sgms2
gene id: 10116:Sgms2
uniprot id: A0A0G2JSK7
uniprot id: A6HVS9
uniprot id: Q4JM44
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sphingomyelin synthase family.
messages: Cell membrane
messages: Expression restricted to late round spermatids and elongating spermatids but not detected in late elongate spermatids and Sertoli cells (at protein level).
messages: Golgi apparatus membrane
messages: Membrane
messages: Palmitoylated on Cys-331, Cys-332, Cys-343 and Cys-348; which plays an important role in plasma membrane localization.
messages: Sphingomyelin synthase that primarily contributes to sphingomyelin synthesis and homeostasis at the plasma membrane. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction appears to depend on the levels of CER and DAG in the plasma membrane (By similarity). Does not use free phosphorylcholine or CDP-choline as donors (By similarity). Can also transfer phosphoethanolamine head group of phosphatidylethanolamine (PE) on to ceramide (CER) to form ceramide phosphoethanolamine (CPE) (By similarity). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting (By similarity). To a lesser extent, plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 (PubMed:21980337). Required for normal bone matrix mineralization (By similarity).

10116:Tlx2
gene id: 10116:Tlx2
uniprot id: A0A0G2JVZ2
names: Subcellular Location Annotation
messages: Nucleus

10116:Or4d6
gene id: 10116:Or4d6
uniprot id: A6I0C5
uniprot id: D3ZSJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Cyth1
gene id: 10116:Cyth1
uniprot id: P97694
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autoinhibited by its C-terminal basic region.
messages: Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.
messages: Cell membrane
messages: Interacts with TRIM23 and CYTIP (By similarity). Interacts (via coiled-coil domain) with FRMD4A (via coiled-coil domain) (By similarity). Interacts with FRMD4B (By similarity). Found in a complex with PARD3, CYTH1 and FRMD4A (By similarity). Interacts (via N-terminal domain) with INAVA (via N-terminal domain) (By similarity).
messages: On embryonic days 15 (15 dpc) and 18 dpc, expression is seen in the mantle and ventricular germinal zones throughout the neuraxis. On postnatal days 0 (P0) and P7, expression is seen in the cerebral neocortex, olfactory mitral and granule cell layers, hippocampal pyramidal and dentate granule cells and the striatum. A lower expression is seen in gray matter in di-, mes- and met-encephali. In the cerebellum, the expression is evident in the external and internal granule cell layers and Purkinje cell layer. On P14, a decreased expression is seen in the di-, mes- and met-encephali. On P21 and thereafter, expression is seen in the olfactory mitral and granule cells, dentate granule cells and the cerebellar granule cells and Purkinje cells.
messages: Present in all tissues tested, with highest protein levels in brain and adrenal.
messages: Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity.
messages: Ubiquitinated by SCF(FBXW11) E3 ubiquitin-protein ligase complex. Ubiquitination induces proteasomal degradation.
messages: adherens junction
messages: cytosol
messages: tight junction

10116:Cdon
gene id: 10116:Cdon
uniprot id: O35158
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).
messages: Detected at low levels in stomach, spleen, brain, large intestine and lung.
messages: Down-regulated in actively dividing cells. Not detectable in suspension cultures. Accumulates only in cells that are attached to a solid substrate (in vitro).
messages: N-glycosylated.
messages: Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3. Interacts with DHH, IHH and SHH (By similarity). Interacts with PTCH1. Interacts with GAS1.

10116:Kdm4d
gene id: 10116:Kdm4d
uniprot id: A1A5Q5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
messages: Nucleus

10116:Otub1
gene id: 10116:Otub1
uniprot id: B2RYG6
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C65 family.
messages: By free ubiquitin: binding of free ubiquitin triggers conformational changes in the OTU domain and formation of a ubiquitin-binding helix in the N-terminus, promoting binding of the conjugated donor ubiquitin in UBE2N/UBC13 to OTUB1.
messages: Cytoplasm
messages: Hydrolase that can specifically remove compared to 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation (By similarity). Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen (By similarity). Acts via its interaction with RNF128/GRAIL (By similarity). Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128 (By similarity). Deubiquitinates estrogen receptor alpha (ESR1) (By similarity). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains (By similarity). Not able to cleave di-ubiquitin (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin (By similarity).
messages: Interacts with RNF128. Forms a ternary complex with RNF128 and USP8. Interacts with FUS and RACK1. Interacts with UBE2D1/UBCH5A, UBE2W/UBC16 and UBE2N/UBC13.
messages: Phosphorylation at Tyr-26 by SRC and SRMS promotes deubiquitination of RPTOR via a non-catalytic process.
messages: Plays a key non-catalytic role in DNA repair regulation by inhibiting activity of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites. Inhibits RNF168 independently of ubiquitin thioesterase activity by binding and inhibiting UBE2N/UBC13, the E2 partner of RNF168, thereby limiting spreading of 'Lys-63'-linked histone H2A and H2AX marks. Inhibition occurs by binding to free ubiquitin: free ubiquitin acts as an allosteric regulator that increases affinity for UBE2N/UBC13 and disrupts interaction with UBE2V1. The OTUB1-UBE2N/UBC13-free ubiquitin complex adopts a configuration that mimics a cleaved 'Lys48'-linked di-ubiquitin chain. Acts as a regulator of mTORC1 and mTORC2 complexes. When phosphorylated at Tyr-26, acts as an activator of the mTORC1 complex by mediating deubiquitination of RPTOR via a non-catalytic process: acts by binding and inhibiting the activity of the ubiquitin-conjugating enzyme E2 (UBE2D1/UBCH5A, UBE2W/UBC16 and UBE2N/UBC13), thereby preventing ubiquitination of RPTOR. Can also act as an inhibitor of the mTORC1 and mTORC2 complexes in response to amino acids by mediating non-catalytic deubiquitination of DEPTOR.

10116:Nr1h2
gene id: 10116:Nr1h2
uniprot id: Q62755
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Forms a heterodimer with RXR. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner. Interacts (when sumoylated) with GPS2; interaction with GPS2 onto hepatic acute phase protein promoters prevents N-Cor corepressor complex dissociation (By similarity). Interacts with ABCA12 and ABCA1; this interaction is required for ABCA1 localization to the cell surface and is necessary for its normal activity and stability (By similarity).
messages: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (By similarity). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity).
messages: Nucleus
messages: Sumoylated by SUMO2 at Lys-395 and Lys-433 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation.

10116:Lyrm2
gene id: 10116:Lyrm2
uniprot id: B2GV91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I LYR family.
messages: Involved in effecient integration of the N-module into mitochondrial respiratory chain complex I.
messages: Mitochondrion

10116:LOC100364335
gene id: 10116:LOC100364335
uniprot id: P18395
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts with STRAP. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, HNRPD and SYNCRIP. The interaction with PABPC1 is direct and RNA-independent. Interacts with EIF4ENIF1/4E-T.
messages: Cytoplasm
messages: P-body
messages: RNA-binding protein involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Required for efficient formation of stress granules.
messages: Stress granule

10116:Naa60
gene id: 10116:Naa60
uniprot id: Q3MHC1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated: autoacetylation is required for optimal acetyltransferase activity.
messages: Belongs to the acetyltransferase family. NAA60 subfamily.
messages: Golgi apparatus membrane
messages: Monomer and homodimer; monomer in presence of substrate and homodimer in its absence.
messages: N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences.

10116:Or8k23
gene id: 10116:Or8k23
uniprot id: A6HMX0
uniprot id: M0R479
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ascl1
gene id: 10116:Ascl1
uniprot id: P19359
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Developing CNS and PNS at embryonic and postnatal stages.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3.
messages: It is first observed after neurulation, in 10.5 dpc rat embryos, and is restricted to subsets of neuroepithelial cells in the spinal cord and the brain, between 10.5 dpc and 13.5 dpc. In the periphery, its expression is restricted to some lineages of neural crest-derived cells, namely in sympathetic and enteric neural precursors. In the PNS its expression is extinguished at or before differentiation.
messages: Nucleus
messages: Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways (PubMed:10648228). Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Involved in the regulation of neuroendocrine cell development in the glandular stomach (By similarity).

10116:Abcg5
gene id: 10116:Abcg5
uniprot id: A6H9I9
uniprot id: Q99PE7
names: Domain
names: Function
names: PTM
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG8 has ATPase activity.
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Cell membrane
messages: Detected in liver (at protein level). Expressed only in liver and intestine.
messages: Heterodimer with ABCG8.
messages: Membrane
messages: N-glycosylated. N-glycosylation is important for efficient export out of the endoplasmic reticulum.
messages: The Walker motif (consensus sequence G-X-X-G-X-G-K-[ST]-T) is expected to bind ATP. Within this motif, the conserved Lys is essential for transport activity mediated by the heterodimer with ABCG8.
messages: The polymorphism at position 583 is found in strains SHR, SHRSP and Wistar Kyoto which are both hypertensive and sitosterolemic. Strains which are hypertensive but not sitosterolemic do not contain a polymorphism at this position.

10116:Cox6c
gene id: 10116:Cox6c
uniprot id: A6HR20
uniprot id: P11951
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

10116:Ilkap
gene id: 10116:Ilkap
uniprot id: Q9Z1Z6
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated in response to stress, such as the addition of ethanol to the culture medium or UV irradiation of cells. Inhibited rather than stimulated, by Magnesium.
messages: Belongs to the PP2C family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cytoplasm
messages: Interacts with ILK.
messages: Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation (By similarity).
messages: Widely expressed. Highest expression observed in kidney, liver and muscle.

10116:Eml1
gene id: 10116:Eml1
uniprot id: Q4V8C3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat EMAP family.
messages: Contains a tandem atypical propeller in EMLs (TAPE) domain. The N-terminal beta-propeller is formed by canonical WD repeats; in contrast, the second beta-propeller contains one blade that is formed by discontinuous parts of the polypeptide chain.
messages: Cytoplasm
messages: Homotrimer; self-association is mediated by the N-terminal coiled coil (By similarity). Does not interact with EML3 (By similarity). Binds repolymerizing microtubules (By similarity). Binds unpolymerized tubulins via its WD repeat region (By similarity). Interacts with TASOR (By similarity).
messages: Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se.
messages: The N-terminal coiled coil is required for association with microtubules.
messages: cytoskeleton
messages: perinuclear region

10116:Psmb6
gene id: 10116:Psmb6
uniprot id: A6HG61
uniprot id: P28073
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolyzing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

10116:Cdca2
gene id: 10116:Cdca2
uniprot id: A6K6P9
names: Subcellular Location Annotation
messages: Nucleus

10116:Acta1
gene id: 10116:Acta1
uniprot id: P68136
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-75 by SETD3.
messages: Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
messages: N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP.
messages: Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others (By similarity). Interacts with alpha-actinin. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X (By similarity). Interacts with TTID. Interacts (via its C-terminus) with USP25 (By similarity).
messages: cytoskeleton

10116:Cdk5r1
gene id: 10116:Cdk5r1
uniprot id: A6HHC0
uniprot id: P61810
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Brain and neuron specific.
messages: Cell membrane
messages: Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity (By similarity). Interacts with EPHA4 and NGEF; may mediate the activation of NGEF by EPHA4 (PubMed:17143272). Interacts with RASGRF2 (PubMed:15128856). The complex p35/CDK5 interacts with CLOCK (By similarity).
messages: Heterodimer of a catalytic subunit and a regulatory subunit.
messages: Membrane
messages: Myristoylated. A proper myristoylation signal is essential for the proper distribution of p35 (By similarity).
messages: Nucleus
messages: Perikaryon
messages: Phosphorylation at Ser-8 and Thr-138 by CDK5 prevents calpain-mediated proteolysis.
messages: The p35 form is proteolytically cleaved by calpain, giving rise to the p25 form. P35 has a 5 to 10 fold shorter half-life compared to p25. The conversion results in deregulation of the CDK5 kinase: p25/CDK5 kinase displays an increased and altered tau phosphorylation in comparison to the p35/CDK5 kinase in vivo.
messages: Ubiquitinated, leading to its degradation: degradation of p35 by proteasome results in down-regulation of CDK5 activity. During this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation. Ubiquitinated by the CRL2(FEM1B) complex, which recognizes the -Gly-Leu-Asp-Arg C-degron at the C-terminus, leading to its degradation.
messages: neuron projection
messages: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution.
messages: perinuclear region

10116:Ppp1r9b
gene id: 10116:Ppp1r9b
uniprot id: O35274
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Cytoplasm
messages: Expression is low during embryogenesis and increases around postnatal day 21.
messages: Interacts with DCLK2 (By similarity). Possibly exists as a homodimer, homotrimer or a homotetramer. Interacts with F-actin, PPP1CA, neurabin-1, TGN38 and D(2) dopamine receptor. Interacts with RGS1, RGS2, RGS4, RGS19 and ADRA1B, ADRA2A, ADRA2B, ADRA2C, CDKN2A, PPP1R2, RASGFR1 and TIAM1. Interacts (via C-terminus) with SPATA13 (via C-terminal tail) (By similarity). Interacts with ADRA2B (By similarity).
messages: Nucleus
messages: Postsynaptic density
messages: Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1. Required for hepatocyte growth factor (HGF)-induced cell migration (By similarity).
messages: Stimulation of D1 (but not D2) dopamine receptors induces Ser-94 and Ser-177 phosphorylation. Dephosphorylation of these residues is mediated by PP1 and possibly PP2A. Spinophilin unphosphorylated or phosphorylated at Ser-94 is concentrated in the postsynaptic density, whereas spinophilin phosphorylated at Ser-177 is absent from the postsynaptic density and enriched in the cytosol. Phosphorylation of spinophilin disrupts its association with F-actin, but does not affect its binding to PP1.
messages: The PP1 binding region is natively unstructured, upon PP1 binding, it acquires structure, blocks a substrate-binding site, and restricts PP1 phosphatase specificity to a subset of substrates.
messages: Ubiquitous. Abundantly expressed in the brain. Expressed at highest levels in hippocampus and at lower levels in the cortex, cerebellum and brainstem. Localizes to the dendritic spines of neurons. Also localizes to aspiny neurons, such as GABAergic interneurons.
messages: adherens junction
messages: cytoskeleton
messages: dendritic spine
messages: filopodium
messages: lamellipodium
messages: ruffle membrane

10116:Plin2
gene id: 10116:Plin2
uniprot id: Q5U2U5
names: Similarity
messages: Belongs to the perilipin family.

10116:Or52e18
gene id: 10116:Or52e18
uniprot id: A6I7G7
uniprot id: D4A3G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Or5b116b
gene id: 10116:Or5b116b
uniprot id: A0A0G2K6B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Dis3l
gene id: 10116:Dis3l
uniprot id: A6J5C2
uniprot id: Q5U2P0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNR ribonuclease family.
messages: Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms (By similarity).
messages: Cytoplasm
messages: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

10116:Grin3b
gene id: 10116:Grin3b
uniprot id: Q8VHN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3B/GRIN3B subfamily.
messages: Cell membrane
messages: Expressed in the hippocampus, the corpus callosum, in the facial and trigeminal nuclei of the brainstem and the ventral horn of the spinal cord.
messages: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex containing GRIN1 and GRIN2A (By similarity).
messages: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.
messages: Postsynaptic cell membrane

10116:Or51b4b
gene id: 10116:Or51b4b
uniprot id: D3ZFT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ddx41
gene id: 10116:Ddx41
uniprot id: A6KAR2
uniprot id: F7EL80
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX41 subfamily.

10116:Ifi27l2b
gene id: 10116:Ifi27l2b
uniprot id: B2RYR1
uniprot id: Q6IEA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

10116:Tcaim
gene id: 10116:Tcaim
uniprot id: P0DKR2
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in peripheral blood leukocytes, mainly in T-lymphocytes.
messages: May regulate T-cell apoptosis.
messages: Mitochondrion
messages: Up-regulated during induction and maintenance of graft acceptance and down-regulated during graft rejection.

10116:Ly49si3
gene id: 10116:Ly49si3
uniprot id: Q5MPU9
names: Subcellular Location Annotation
messages: Membrane

10116:Mterf1
gene id: 10116:Mterf1
uniprot id: A6K274
uniprot id: G3V6Z9
uniprot id: Q9EPI8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mTERF family.
messages: Contains nine structural repeats of about 35 residues, where each repeat contains three helices. The repeats form a left-handed superhelical assembly with a solenoid structure that wraps itself around DNA (By similarity).
messages: Is a phosphoprotein. While the DNA-binding activity is unaffected by the phosphorylation/dephosphorylation state, only the phosphorylated form of the protein is active for termination activity. Functioning seems to be regulated by phosphorylation.
messages: Mitochondrion
messages: Monomer.
messages: Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand (By similarity).

10116:Ufc1
gene id: 10116:Ufc1
uniprot id: A6JFW9
uniprot id: Q6BBI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
messages: E1-like enzyme which specifically catalyzes the second step in ufmylation. Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.
messages: E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.
messages: Interacts with UBA5 (via C-terminus). Interacts with UFL1. Interacts with KIRREL3. Interacts with UFM1.

10116:Magi1
gene id: 10116:Magi1
uniprot id: Q4L1J4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts through its WW 2 domain with SYNPO and through its PDZ 5 domain with ACTN4. Interacts with cytoplasmic domain of ADGRB1. Interacts via its WW domains with DRPLA (By similarity). Interacts with ESAM, LRP2 and CXADR. May interact with CTNNB1. Interacts through its PDZ 1 domain with NET1 (By similarity). Interacts with ASIC3 and AMOT. Interacts with FCHSD2 (By similarity). Interacts with IGSF5/JAM4 and through its PDZ 2 and 3 domains with NPHS1 forming a tripartite complex (PubMed:16155592). Interacts with DDN (PubMed:16751601). May interact (via PDZ domain) with RAPGEF2 (By similarity). Interacts with DLL1 (By similarity). Interacts with KCNJ10 and possibly with KCNJ10/KCNJ16 heterodimer; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney tubular cells (By similarity). Interacts with PRRG4 (via cytoplasmic domain) (By similarity).
messages: May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface.
messages: Membrane
messages: tight junction

10116:Kcnd1
gene id: 10116:Kcnd1
uniprot id: A6KP76
uniprot id: D3ZYK3
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

10116:Fkbp1a
gene id: 10116:Fkbp1a
uniprot id: Q62658
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
messages: Inhibited by both FK506 and rapamycin.
messages: Interacts with TGFBR1; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation (By similarity). Interacts with ACVR1B and SMAD7. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1) (By similarity). Interacts directly with RYR2 (PubMed:20431056). Interacts directly with RYR3 (By similarity). Interacts directly with RYR1 (By similarity). Interacts with GLMN; rapamycin and FK506 abolish the interaction with GLMN in a dose dependent manner (By similarity).
messages: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
messages: Sarcoplasmic reticulum membrane
messages: Ubiquitous.
messages: cytosol

10116:Zbed4
gene id: 10116:Zbed4
uniprot id: D3ZUV0
names: Subcellular Location Annotation
messages: Nucleus

10116:Foxn3
gene id: 10116:Foxn3
uniprot id: A0A0G2JYT8
uniprot id: A6JEF9
uniprot id: D3ZIJ7
names: Function
names: Subcellular Location Annotation
messages: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
messages: Nucleus

10116:Camk2b
gene id: 10116:Camk2b
uniprot id: A6IKR8
uniprot id: A6IKR9
uniprot id: F1LNI8
uniprot id: F1LUE2
uniprot id: G3V9G3
uniprot id: P08413
uniprot id: Q63094
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
messages: Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
messages: By cocaine in cardiomyocytes.
messages: CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other (By similarity). Interacts with SYNGAP1, CAMK2N2 and MPDZ (PubMed:9724800, PubMed:15312654). Interacts with FOXO3 (By similarity). Interacts (when in a kinase inactive state not associated with calmodulin) with ARC; leading to target ARC to inactive synapses (PubMed:22579289). Interacts with CAMK2N1; this interaction requires CAMK2B activation by Ca(2+) (PubMed:11182241).
messages: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:12873385, PubMed:15312654). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise (PubMed:17272343). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-134' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (By similarity).
messages: Sarcoplasmic reticulum membrane
messages: Synapse
messages: The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
messages: centrosome
messages: cytoskeleton

10116:Pfn2
gene id: 10116:Pfn2
uniprot id: Q9EPC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
messages: Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio (By similarity). Interacts with PFN2 (By similarity). Interacts with ACTMAP (via N-terminus); the interaction may facilitate efficient cleavage of the acetylated N-terminus of immature actin by ACTMAP (By similarity).
messages: cytoskeleton

10116:Ppm1g
gene id: 10116:Ppm1g
uniprot id: Q8K3W9
names: Similarity
messages: Belongs to the PP2C family.

10116:Pcdha4
gene id: 10116:Pcdha4
uniprot id: A0A0G2K783
uniprot id: I6LBW4
uniprot id: Q593X7
uniprot id: Q593Y1
uniprot id: Q767H7
uniprot id: Q767I0
uniprot id: Q767I1
uniprot id: Q767I2
uniprot id: Q767I6
uniprot id: Q767I7
uniprot id: Q767I8
uniprot id: Q767I9
uniprot id: Q767J1
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cadherin 1 to cadherin 4 domains mediate homophilic trans-interaction, the interaction with an identical protocadherin expressed by a neighboring cell. This is a head-to-tail interaction, the cadherin 1 domain interacting with the cadherin 4 domain and the cadherin 2 domain interacting the cadherin 3 domain of the other protocadherin. The cadherin 6 domain mediates promiscuous interactions with protocadherins on the same cell membrane. Each cadherin domain binds three calcium ions.
messages: Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.
messages: Cell membrane
messages: Detected in brain.
messages: Forms homodimers in trans (molecules expressed by two different cells). Forms promiscuous heterodimers in cis (at the plasma membrane of the same cell) with other protocadherins. Interacts with FYN.
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

10116:LOC100909977
gene id: 10116:LOC100909977
uniprot id: F1MA83
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Cpt1a
gene id: 10116:Cpt1a
uniprot id: A6HYK3
uniprot id: P32198
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A conformation change in the N-terminal region spanning the first 42 residues plays an important role in the regulation of enzyme activity by malonyl-CoA.
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:16908527, PubMed:21990363). Plays an important role in hepatic triglyceride metabolism (PubMed:18349115).
messages: Homohexamer and homotrimer (PubMed:19136561). Identified in a complex that contains at least CPT1A, ACSL1 and VDAC1 (PubMed:21622568). Also identified in complexes with ACSL1 and VDAC2 and VDAC3.
messages: Inhibited by malonyl-CoA.
messages: Liver and kidney.
messages: Membrane
messages: Mitochondrion outer membrane

10116:Stip1
gene id: 10116:Stip1
uniprot id: A6HZN1
uniprot id: O35814
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a co-chaperone for HSP90AA1 (By similarity). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (PubMed:9528774).
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Nucleus
messages: Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (By similarity). Forms a complex with HSPA8/HSC70, HSPCA/HSP-86 and HSPCB/HSP-84. Interacts with PACRG. Interacts with EEF1AKMT3 (By similarity). Interacts with HSP90/HSP90AA1; the interaction dissociates the PPP5C:HSP90AA1 interaction. Interacts with FLCN, FNIP1 and FNIP2 (By similarity). Interacts with HSPA8/HSC70 (PubMed:9528774). Interacts with HSP90AB1; upon SMYD2-dependent HSP90AB1 methylation (By similarity).
messages: The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90 (By similarity).

10116:Dnase1l1
gene id: 10116:Dnase1l1
uniprot id: A6KRR9
uniprot id: A6KRS0
uniprot id: Q2QDE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNase I family.
messages: Endoplasmic reticulum

10116:Mme
gene id: 10116:Mme
uniprot id: A6JVN6
uniprot id: P07861
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M13 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.
messages: Inhibited in a dose dependent manner by sialorphin.
messages: Membrane
messages: Myristoylation is a determinant of membrane targeting.
messages: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:2966343). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:2966343). Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (By similarity). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:2966343). Involved in the degradation of the atrial natriuretic factor (ANF) (PubMed:2966343). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (By similarity).

10116:Rpl39
gene id: 10116:Rpl39
uniprot id: A6JMH4
uniprot id: P62893
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL39 family.
messages: Component of the large ribosomal subunit (By similarity). Interacts with IMPACT (By similarity).
messages: Cytoplasm
messages: RNA-binding component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: This protein is the smallest and one of the most basic of the proteins in liver ribosomes.

10116:Uox
gene id: 10116:Uox
uniprot id: P09118
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Competitively inhibited by xanthine.
messages: Expressed in liver. Not detected in other tissues tested.
messages: Peroxisome

10116:Capn11
gene id: 10116:Capn11
uniprot id: D3ZXF4
uniprot id: Q4V8Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
messages: Heterodimer of a large (catalytic) and a small (regulatory) subunit.
messages: acrosome

10116:Aldh1a2
gene id: 10116:Aldh1a2
uniprot id: A6KER4
uniprot id: Q63639
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (By similarity) (PubMed:8663198). Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (By similarity). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (PubMed:8663198). Lacks activity with benzaldehyde, acetaldehyde and octanal (PubMed:8663198). Displays complete lack of activity with citral (PubMed:8663198).
messages: Cytoplasm
messages: Found in testis and less abundantly in lung, brain, heart, liver and kidney.
messages: Homotetramer.

10116:RT1-CE13
gene id: 10116:RT1-CE13
uniprot id: Q6MG31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Involved in the presentation of foreign antigens to the immune system.
messages: Membrane

10116:Gpr153
gene id: 10116:Gpr153
uniprot id: A0A8J8Y8J7
uniprot id: A6IUH7
uniprot id: D4ABT6
names: Subcellular Location Annotation
messages: Membrane

10116:Tekt4
gene id: 10116:Tekt4
uniprot id: A6HD28
uniprot id: Q6AXV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tektin family.
messages: Interacts with TEKT3.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). Contributes to normal sperm motility (By similarity).
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: cilium axoneme
messages: flagellum

10116:Or1p1
gene id: 10116:Or1p1
uniprot id: M0R8S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Dnase1
gene id: 10116:Dnase1
uniprot id: A6K4T9
uniprot id: P21704
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNase I family.
messages: Divalent metal cations. Prefers Ca(2+) or Mg(2+).
messages: Nucleus envelope
messages: Secreted
messages: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:8428592, PubMed:15796714). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (PubMed:15796714). Among other functions, seems to be involved in cell death by apoptosis (PubMed:8428592, PubMed:15796714). Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).
messages: Zymogen granule

10116:Ss18l2
gene id: 10116:Ss18l2
uniprot id: A6I451
uniprot id: M0R551
names: Similarity
messages: Belongs to the SS18 family.

10116:Mrps18b
gene id: 10116:Mrps18b
uniprot id: A6KT69
uniprot id: F6Q5K7
uniprot id: Q6MG10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Mitochondrion

10116:Gnao1
gene id: 10116:Gnao1
uniprot id: A6JY81
uniprot id: P59215
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: Cell membrane
messages: Deamidation of Asn-346 converts alpha-1 to alpha-3.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Forms a complex with GNB1 and GNG3 (By similarity). Interacts with RGS14 (By similarity). Interacts with RGS19 (By similarity).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 (By similarity).
messages: Histaminylated at Gln-205 residues by TGM2.
messages: Membrane

10116:LOC171573
gene id: 10116:LOC171573
uniprot id: Q9QXN2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PATE family.
messages: Monomer.
messages: Secreted

10116:Cyp3a9
gene id: 10116:Cyp3a9
uniprot id: A0A9K3Y7I1
uniprot id: Q5PQX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

10116:Tmem121
gene id: 10116:Tmem121
uniprot id: D3ZMR5
names: Similarity
messages: Belongs to the TMEM121 family.

10116:Blzf1
gene id: 10116:Blzf1
uniprot id: Q6AYB8
names: Caution
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.
messages: Golgi apparatus membrane
messages: Interacts with GORASP2 (PubMed:11739401). Interacts with the GTP-bound form of RAB2, but not with other Golgi Rab proteins (PubMed:11739401). Identified in a complex with RAB2 and GORASP2 (PubMed:11739401).
messages: Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface.
messages: The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2.
messages: Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation.
messages: Was initially thought to be a potential transcription factor, localized in the nucleus.

10116:Psme3ip1
gene id: 10116:Psme3ip1
uniprot id: Q6AY90
names: Subcellular Location Annotation
messages: Nucleus

10116:Qng1
gene id: 10116:Qng1
uniprot id: A6KAK3
uniprot id: B4F797
uniprot id: F7FM32
names: Function
names: Similarity
messages: Belongs to the QNG1 protein family.
messages: Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.

10116:Proca1
gene id: 10116:Proca1
uniprot id: Q4V7B4
names: Similarity
messages: Belongs to the PROCA1 family.

10116:Desi1
gene id: 10116:Desi1
uniprot id: A6HT40
uniprot id: Q4KM30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DeSI family.
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts with UBQLN4; leading to the export of UBQLN4 from the nucleus (By similarity).
messages: Nucleus
messages: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (By similarity).

10116:Med31
gene id: 10116:Med31
uniprot id: A6HGE1
uniprot id: D4A7J4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

10116:Or1f30
gene id: 10116:Or1f30
uniprot id: A0A8I6AC95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Olr1311
gene id: 10116:Olr1311
uniprot id: A6J3M9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Cdh5
gene id: 10116:Cdh5
uniprot id: A6JXX3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

10116:Adgrf4
gene id: 10116:Adgrf4
uniprot id: D3ZTY4
names: Subcellular Location Annotation
messages: Membrane

10116:Tmem201
gene id: 10116:Tmem201
uniprot id: D3ZBW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM201 family.
messages: Membrane
messages: Nucleus inner membrane

10116:Calcr
gene id: 10116:Calcr
uniprot id: A0A0H2UHI1
uniprot id: A0A0H2UHI3
uniprot id: A6K2A3
uniprot id: A6K2A4
uniprot id: P32214
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Interacts with GPRASP2.
messages: Membrane
messages: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

10116:Gpr88
gene id: 10116:Gpr88
uniprot id: A6HV91
uniprot id: Q9ESP4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Detected at embryonic day 16 (16 dpc) in the striatum. From 16 dpc to 20 dpc to adulthood, the highest expression levels of protein is observed in the striatum, olfactory tubercle, nucleus accumbens, amygdala, and neocortex.
messages: Expressed predominantly in the striatum (PubMed:11056049). Expressed also in olfactory tubercle, nucleus accumbens, amygdala, and neocortex. Spinal cord, pons, and medulla expression remains discrete (PubMed:26918661). Also expressed in peripheral tissues, including adrenal cortex (16 dpc to 21 dpc) and cochlear ganglia (19 dpc to P3) and also at moderate levels in retina (18 dpc to 19 dpc) and spleen (21 dpc to P7) (PubMed:26918661).
messages: Membrane
messages: Nucleus
messages: Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function.

10116:Ugp2
gene id: 10116:Ugp2
uniprot id: A0A9K3Y8H8
uniprot id: Q4V8I9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

10116:Tut4
gene id: 10116:Tut4
uniprot id: A0A0G2JZ04
uniprot id: A6JYV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Cytoplasm

10116:Sorcs1
gene id: 10116:Sorcs1
uniprot id: A0A8I5ZLQ5
uniprot id: A0A8I6AEA1
uniprot id: A0A8I6AF53
uniprot id: F1LUZ4
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

10116:Man1b1
gene id: 10116:Man1b1
uniprot id: A6JT43
uniprot id: B2GUY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 47 family.
messages: Endoplasmic reticulum membrane
messages: Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2) (By similarity).

10116:Far1
gene id: 10116:Far1
uniprot id: A0A096MJW2
uniprot id: A6I887
uniprot id: A6I889
uniprot id: Q66H50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols. In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis.
messages: Interacts with PEX19; PEX19 mediates the targeting of FAR1 to peroxisomes.
messages: Peroxisome membrane

10116:Dmrtb1
gene id: 10116:Dmrtb1
uniprot id: D4A494
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

10116:Ston1
gene id: 10116:Ston1
uniprot id: A6H9B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Stoned B family.
messages: Cytoplasm

10116:Cyb5r4
gene id: 10116:Cyb5r4
uniprot id: A0A0G2JSK2
uniprot id: A0A8I6A4B1
uniprot id: A0A8I6GKQ4
uniprot id: A6I1W7
uniprot id: Q68EJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome b5 family.
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum
messages: Isoform 2 is expressed in testis, brain, skeletal muscle and in the male germline.
messages: NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS).

10116:Gja10
gene id: 10116:Gja10
uniprot id: A0A654ID08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

10116:Bcam
gene id: 10116:Bcam
uniprot id: Q9ESS6
names: Function
names: Subcellular Location Annotation
messages: Laminin alpha-5 receptor. May mediate intracellular signaling (By similarity).
messages: Membrane

10116:Prl8a5
gene id: 10116:Prl8a5
uniprot id: Q62654
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

10116:Mst1r
gene id: 10116:Mst1r
uniprot id: D3ZYM4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Cacna1a
gene id: 10116:Cacna1a
uniprot id: O70368
uniprot id: P54282
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily.
messages: Brain specific. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells. Also found in heart, in kidney distal convoluted tubule (DCT), and in pituitary.
messages: Cell membrane
messages: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
messages: Membrane
messages: Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity (By similarity). Interacts (via C-terminal CDB motif) with CABP1 in the pre- and postsynaptic membranes (PubMed:11865310). Interacts with the spider omega-agatoxin-IVA (AC P30288) (PubMed:1311418).
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P30288) (PubMed:1311418). They are however insensitive to dihydropyridines (DHP).

10116:Apold1
gene id: 10116:Apold1
uniprot id: A6IME9
uniprot id: Q6B959
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the apolipoprotein L family.
messages: Cell membrane
messages: Expressed at high levels in vessels from developing heart from 12 dpc to P12. Expression decreases markedly from P12 to P17, and is no longer detectable at P30.
messages: In the brain, by electrical or chemical seizures (at protein level).
messages: May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability.
messages: Present at low levels in brain vascular cells (at protein level).

10116:Olr1104
gene id: 10116:Olr1104
uniprot id: D4AE45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:B3gat1
gene id: 10116:B3gat1
uniprot id: A6JYC4
uniprot id: O35789
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 43 family.
messages: Brain. Greater expression found in the cerebral cortex than the cerebellum.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer (PubMed:9804790). Interacts with SAR1A (PubMed:19181664).
messages: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.
messages: Membrane
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.

10116:Slc22a13
gene id: 10116:Slc22a13
uniprot id: B2GV36
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Anion antiporter that mediates the transport of nicotinate (PubMed:35144162). Possibly involved in nicotinate intestinal reabsorption (By similarity).
messages: Apical cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Glycosylated.
messages: In contrast with human ortholog, not able to transport urate and orotate (PubMed:35144162).

10116:Ncstn
gene id: 10116:Ncstn
uniprot id: A6JG19
uniprot id: Q8CGU6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nicastrin family.
messages: Component of the gamma-secretase complex. The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Binds to proteolytic processed C-terminal fragments C83 and C99 of the amyloid precursor protein (APP). Interacts with PSEN1 and PSEN2.
messages: Cytoplasmic vesicle membrane
messages: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
messages: Melanosome
messages: Membrane
messages: N-glycosylated.

10116:Musk
gene id: 10116:Musk
uniprot id: Q62838
names: Activity Regulation
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: From 14.0 dpc, expressed in developing myotomes. Once the muscle is innervated, localized to the neuromuscular junction (NMJ), where its expression is restricted to synaptic nuclei. Expression drops after birth.
messages: Monomer (By similarity). Homodimer (Probable). Interacts with LRP4; the heterodimer forms an AGRIN receptor complex that binds AGRIN resulting in activation of MUSK. Forms a heterotetramer composed of 2 DOK7 and 2 MUSK molecules which facilitates MUSK trans-autophosphorylation on tyrosine residue and activation. Interacts (via cytoplasmic part) with DOK7 (via IRS-type PTB domain); requires MUSK phosphorylation. Interacts with DVL1 (via DEP domain); the interaction is direct and mediates the formation of a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering (By similarity). Interacts with PDZRN3; this interaction is enhanced by agrin (By similarity). Interacts with FNTA; the interaction is direct and mediates AGRIN-induced phosphorylation and activation of FNTA (By similarity). Interacts with CSNK2B; mediates regulation by CK2 (By similarity). Interacts (via the cytoplasmic domain) with DNAJA3. Interacts with NSF; may regulate MUSK endocytosis and activity (By similarity). Interacts with CAV3; may regulate MUSK signaling (By similarity). Interacts with RNF31 (By similarity). Interacts with DOK7 (PubMed:23326516).
messages: Muscle specific.
messages: Neddylated.
messages: Phosphorylated (PubMed:23326516). Phosphorylation is induced by AGRIN in a LRP4-dependent manner (PubMed:23326516). Autophosphorylated (By similarity). Autophosphorylation at Tyr-553 is required for interaction with DOK7 which in turn stimulates the phosphorylation and the activation of MUSK (By similarity).
messages: Positively regulated by CK2.
messages: Postsynaptic cell membrane
messages: Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:23326516). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation.
messages: Ubiquitinated by PDZRN3. Ubiquitination promotes endocytosis and lysosomal degradation (By similarity).
messages: Up-regulated upon denervation (at protein level).

10116:Chd2
gene id: 10116:Chd2
uniprot id: A0A096MJY0
uniprot id: A6JBX9
names: Subcellular Location Annotation
messages: Nucleus

10116:Padi4
gene id: 10116:Padi4
uniprot id: A6ITP3
uniprot id: O88807
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Autocitrullination at Arg-372 and Arg-374 inactivates the enzyme.
messages: Belongs to the protein arginine deiminase family.
messages: Binds 5 Ca(2+) ions per subunit.
messages: Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci (By similarity). Required for the formation of neutrophil extracellular traps (NETs); NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1 (By similarity).
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Epidermis.
messages: Nucleus

10116:Slc5a1
gene id: 10116:Slc5a1
uniprot id: A6IK70
uniprot id: P53790
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Appears on embryonic day 18 and gradually increases until birth.
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (By similarity). Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (By similarity). Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules (By similarity). Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception (By similarity). Acts as a water channel enabling passive water transport in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity comparable to aquaporins and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine.
messages: Membrane
messages: N-glycosylation is not necessary for the cotransporter function.
messages: The cholesterol-binding site is formed by transmembrane helices TM1, TM7 and TM13.

10116:Olr1335
gene id: 10116:Olr1335
uniprot id: A0A0G2JUC2
uniprot id: A6J3P1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Cyp2j16
gene id: 10116:Cyp2j16
uniprot id: A0A0G2JTQ9
names: Similarity
messages: Belongs to the cytochrome P450 family.

10116:Or4c31b
gene id: 10116:Or4c31b
uniprot id: A0A8I6A1X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Gpn2
gene id: 10116:Gpn2
uniprot id: D4A7C0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Heterodimers with GPN1 or GPN3. Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

10116:Gss
gene id: 10116:Gss
uniprot id: A6KI44
uniprot id: P46413
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7862666). Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:7862666). Participates in ophthalmate biosynthesis in hepatocytes (By similarity).
messages: Homodimer.

10116:Arf5
gene id: 10116:Arf5
uniprot id: A6IEA6
uniprot id: P84083
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus
messages: Interacts (when activated) with GGA1, GGA2 and GGA3; the interaction is required for proper subcellular location of GGA1, GGA2 and GGA3 (By similarity). Binds ASAP2 (By similarity). Interacts with NCS1/FREQ at the Golgi complex. Interacts with RAB11FIP3 and RAB11FIP4 (By similarity).
messages: Membrane
messages: perinuclear region
messages: trans-Golgi network membrane

10116:Plcz1
gene id: 10116:Plcz1
uniprot id: Q5FX52
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro.
messages: Nucleus
messages: The EF-hand and C2 domains are essential for triggering Ca(2+) oscillating activity and the regulation of PLCZ1 enzyme activity.
messages: The X-Y linker region between PI-PLC X-box and Y-box domains may be a target for proteolysis and may play an important regulatory role during fertilization.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
messages: perinuclear region

10116:Rps15a
gene id: 10116:Rps15a
uniprot id: A6I8G0
uniprot id: P62246
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the 40S ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Required for proper erythropoiesis.
messages: Cytoplasm
messages: nucleolus

10116:LOC688389
gene id: 10116:LOC688389
uniprot id: F1M163
names: Subcellular Location Annotation
messages: Membrane

10116:Asb1
gene id: 10116:Asb1
uniprot id: A6JQT2
uniprot id: B5DF97
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

10116:Eno4
gene id: 10116:Eno4
uniprot id: A0A8I6AN31
uniprot id: A6JI77
uniprot id: D3ZRT2
names: Similarity
messages: Belongs to the enolase family.

10116:Clcn4
gene id: 10116:Clcn4
uniprot id: F7F9W4
uniprot id: Q56A19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

10116:Cse1l
gene id: 10116:Cse1l
uniprot id: A6JXI1
uniprot id: D3ZPR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

10116:Pcdhgb8
gene id: 10116:Pcdhgb8
uniprot id: A0A9K3Y750
uniprot id: I6LBX7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

10116:Txlna
gene id: 10116:Txlna
uniprot id: B2GV14
names: Similarity
messages: Belongs to the taxilin family.

10116:Pcdhb12
gene id: 10116:Pcdhb12
uniprot id: Q63418
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in brain.
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

10116:C5ar2
gene id: 10116:C5ar2
uniprot id: A0A8L2QZB1
uniprot id: A6J8A1
uniprot id: Q5XPY4
uniprot id: Q695P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.
messages: Membrane
messages: Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.

10116:Senp3
gene id: 10116:Senp3
uniprot id: A6HFT2
uniprot id: Q3MID8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

10116:Usp19
gene id: 10116:Usp19
uniprot id: Q6J1Y9
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: By streptozotocin and fasting in skeletal muscle.
messages: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing thier ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains (By similarity).
messages: Endoplasmic reticulum membrane
messages: Expressed in testis, heart, kidney and skeletal muscle. Low levels of expression are detectable in all other tissues screened.
messages: Interacts with and stabilizes RNF123. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with HIF1A (via N-terminus) (By similarity).

10116:Vps54
gene id: 10116:Vps54
uniprot id: Q9JMK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling.
messages: Belongs to the VPS54 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54 (By similarity). EIPR1 interacts with GARP complex and mediates its recruitment to the trans-Golgi network (By similarity). Interacts with VPS51 in an EIPR1-independent manner (By similarity).
messages: Membrane
messages: Ubiquitously expressed at low level.
messages: trans-Golgi network

10116:Olr927
gene id: 10116:Olr927
uniprot id: D3ZP24
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Eif2ak3
gene id: 10116:Eif2ak3
uniprot id: A6IA60
uniprot id: Q9Z1Z1
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ADP-ribosylated by PARP16 upon ER stress, which increases kinase activity.
messages: Autophosphorylated. Phosphorylated at Tyr-611 following endoplasmic reticulum stress, leading to activate its tyrosine-protein kinase activity. Dephosphorylated by PTPN1/TP1B, leading to inactivate its enzyme activity (By similarity).
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
messages: By ER stress.
messages: Endoplasmic reticulum membrane
messages: Interacts with DNAJC3 and MFN2 (By similarity). Forms dimers with HSPA5/BIP in resting cells (By similarity). Oligomerizes in ER-stressed cells (PubMed:10854322). Interacts with TMEM33 (By similarity). Interacts with PDIA6 (By similarity). Interacts with LACC1 (By similarity).
messages: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (By similarity). Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function (By similarity).
messages: N-glycosylated.
messages: Perturbation in protein folding in the endoplasmic reticulum (ER) promotes reversible dissociation from HSPA5/BIP and oligomerization, resulting in transautophosphorylation and kinase activity induction.
messages: The lumenal domain senses perturbations in protein folding in the ER, probably through reversible interaction with HSPA5/BIP.
messages: Ubiquitous.

10116:Dbx1
gene id: 10116:Dbx1
uniprot id: A6JBG0
uniprot id: Q5NSW5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the H2.0 homeobox family.
messages: By Pax6.
messages: Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity).
messages: Nucleus

10116:Ccn4
gene id: 10116:Ccn4
uniprot id: Q99PP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Downstream regulator in the Wnt/Frizzled-signaling pathway (By similarity). Associated with cell survival. Adheres to skin and melanoma fibroblasts (By similarity). In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan (By similarity).
messages: Secreted

10116:Pde4a
gene id: 10116:Pde4a
uniprot id: P54748
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit (By similarity). Site 2 has a preference for magnesium and/or manganese ions (By similarity).
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions.
messages: Efficiently hydrolyzes cAMP.
messages: Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes.
messages: Incomplete sequence.
messages: Inhibited by rolipram.
messages: Interacts with LYN (via SH3 domain). Interacts with ARRB2.
messages: Isoform 2 is testis specific.
messages: Membrane
messages: Phosphorylated by MAPKAPK2 at Ser-147; it counteracts PKA-induced activation of PDE4A and modulates intracellular cAMP levels. Likely involved in cellular desensitization to cAMP signaling.
messages: Proteolytically cleaved by CASP3.
messages: cytosol

10116:Mrps11
gene id: 10116:Mrps11
uniprot id: A6JC26
uniprot id: D4A040
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

10116:MAST1
gene id: 10116:MAST1
uniprot id: A6IY58
uniprot id: Q810W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Both isoform 1 and isoform 2 appear to be restricted to the brain. Isoform 2 is strongly expressed in the neurons of the subventricular zone and granule cells of the olfactory bulb, Islands of Calleja, hippocampal dentate gyrus and cerebellum.
messages: Cell membrane
messages: Interacts with the microtubules. Part of a low affinity complex that associates with, but is distinct from, the postsynaptic density. Interacts with SNTB2.
messages: Microtubule-associated protein essential for correct brain development (By similarity). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Isoform 2 may play a role in neuronal transcriptional regulation.
messages: Nucleus
messages: axon
messages: cytoskeleton
messages: dendrite

10116:Gstm1
gene id: 10116:Gstm1
uniprot id: P04905
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. The olfactory GST may be crucial for the acuity of the olfactory process (PubMed:8110735, PubMed:8664265). Participates in the formation of novel hepoxilin regioisomers (By similarity).
messages: Cytoplasm
messages: Homodimer or heterodimer.
messages: Yb subclass selectively binds steroid hormones.

10116:Myorg
gene id: 10116:Myorg
uniprot id: A6IIV2
uniprot id: D4AE63
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

10116:Ube2d2b
gene id: 10116:Ube2d2b
uniprot id: A6KPH8
uniprot id: P70711
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection Plays a role in early maturation of the testis.
messages: Interacts with CNOT4 (via RING domain).
messages: Testis-specific. Mainly expressed in the round spermatids (at protein level).

10116:Zfp280d
gene id: 10116:Zfp280d
uniprot id: A0A0G2JU78
uniprot id: A6KEP7
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

10116:Dlgap1
gene id: 10116:Dlgap1
uniprot id: A0A0G2K6T7
uniprot id: A6KF81
uniprot id: A6KF83
uniprot id: G3V849
uniprot id: P97836
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SAPAP family.
messages: Cell membrane
messages: Expressed in brain and testis.
messages: Highest level of isoform 1 in the brain of newborn rats. Increasing levels of isoforms 2, 3, 4, and 5 in the brain of newborn rats from birth to 6 weeks of postnatal development. Increasing but low level of isoform 6 is expressed in the brain from 2 to 6 weeks of postnatal development.
messages: Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG3, DLG4 and AIP1. Interacts with the PDZ domain of SHANK1, SHANK2 and SHANK3. Found in a complex with DLG4 and SHANK1, SHANK2 or SHANK3. Found in a complex with DLG4 and BEGAIN. Interacts with DYL2 and LRFN1. Interacts with MPP2 (via the SH3-Guanylate kinase-like sub-module) (PubMed:27756895).
messages: Part of the postsynaptic scaffold in neuronal cells.
messages: Postsynaptic density
messages: Synapse
messages: Ubiquitinated by TRIM3; leading to proteasomal degradation.

10116:As3mt
gene id: 10116:As3mt
uniprot id: Q8VHT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.
messages: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH.
messages: cytosol

10116:Rhcg
gene id: 10116:Rhcg
uniprot id: Q7TNN9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+). As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (By similarity). May act as a CO2 channel providing for renal acid secretion (By similarity).
messages: Apical cell membrane
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Cell membrane
messages: Expressed by connecting tubule cells and intercalated cells of the collecting duct in kidney (at protein level).
messages: Homotrimer.
messages: N-glycosylated.

10116:Dffb
gene id: 10116:Dffb
uniprot id: Q99N34
names: Activity Regulation
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of DFFA and DFFB (By similarity). Interacts with H1-1 (By similarity).
messages: Inhibited by DFFA (DFF45).
messages: Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
messages: Nucleus

10116:Rom1
gene id: 10116:Rom1
uniprot id: A6HZX7
uniprot id: Q5PPM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRPH2/ROM1 family.
messages: Homodimer; disulfide-linked (By similarity). Forms a homotetramer (By similarity). Forms a heterotetramer with PRPH2 (By similarity). Homotetramer and heterotetramer core complexes go on to form higher order complexes by formation of intermolecular disulfide bonds (By similarity). Interacts with STX3 (By similarity). Interacts with SNAP25 (By similarity).
messages: Membrane
messages: Photoreceptor inner segment membrane
messages: Photoreceptor outer segment membrane
messages: Plays a role in rod outer segment (ROS) morphogenesis (By similarity). May play a role with PRPH2 in the maintenance of the structure of ROS curved disks (By similarity). Plays a role in the organization of the ROS and maintenance of ROS disk diameter (By similarity). Involved in the maintenance of the retina outer nuclear layer (By similarity).

10116:Or14c39
gene id: 10116:Or14c39
uniprot id: D4A3H7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Nxph3
gene id: 10116:Nxph3
uniprot id: B2GVB5
uniprot id: Q9Z2N5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the neurexophilin family.
messages: Brain. Detected in several other tissues.
messages: May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.
messages: May be signaling molecules that resemble neuropeptides.
messages: May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).
messages: Secreted

10116:Coq2
gene id: 10116:Coq2
uniprot id: Q499N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis (PubMed:20526342). Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group (such as all-trans-nonaprenyl diphosphate) (PubMed:20526342). The length of the polyprenyl side chain varies depending on the species, in humans, the side chain is comprised of 10 isoprenyls producing CoQ10 (also known as ubiquinone), whereas rodents predominantly generate CoQ9 (PubMed:20526342). However, this specificity is not complete, human tissues have low amounts of CoQ9 and rodent organs contain some CoQ10 (By similarity). Plays a central role in the biosynthesis of CoQ9 (By similarity). CoQ9 is a vital molecule that transports electrons from mitochondrial respiratory chain complexes (By similarity). CoQs also function as cofactors for uncoupling protein and plays a role as regulator of the extracellularly-induced ceramide-dependent apoptotic pathway (By similarity). Regulates mitochondrial permeability transition pore (mPTP) opening and ROS production (pivotal events in cell death) in a tissue specific manner (PubMed:22387164).
messages: Mitochondrion inner membrane

10116:Zscan20
gene id: 10116:Zscan20
uniprot id: D3ZCC2
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

10116:Nrros
gene id: 10116:Nrros
uniprot id: Q5BK65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LRRC32/LRRC33 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Interacts (via LRR repeats) with TLR2, TLR3, TLR4, TLR9 and probably other Toll-like receptors (By similarity). Interacts with CYBB/NOX2; the interaction is direct. Interacts with TGFB1; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1, leading to regulate activation of TGF-beta-1 (By similarity).
messages: Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS. Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling.

10116:Olig1
gene id: 10116:Olig1
uniprot id: Q9WUQ3
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By SHH.
messages: Expressed in oligodendrocytes of the postnatal optical nerve up to day 30, then the number of expressing cells decreases.
messages: Expressed specifically in the brain, including the corpus callosum, hippocampal and cerebral white matter. Also detected in cells scattered in gray matter, most probably in oligodendrocytes.
messages: Nucleus
messages: Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).

10116:Inpp4a
gene id: 10116:Inpp4a
uniprot id: Q62784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.
messages: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PubMed:7608176). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (PubMed:7608176). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Early endosome membrane
messages: Interacts with INPP5F.
messages: Nucleus
messages: Postsynaptic density
messages: Recycling endosome membrane
messages: Widely expressed. Expressed at highest levels in the brain, heart and skeletal muscle.

10116:Meis1
gene id: 10116:Meis1
uniprot id: A0A8I6GMM6
uniprot id: B1WC31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

10116:Mgat5b
gene id: 10116:Mgat5b
uniprot id: A0A8I5ZTQ1
uniprot id: A0A8I6A8E1
uniprot id: A6HL04
uniprot id: D3ZRS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane

10116:Lias
gene id: 10116:Lias
uniprot id: Q5XIH4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

10116:Cfap91
gene id: 10116:Cfap91
uniprot id: D3ZBC9
names: Similarity
messages: Belongs to the CFAP91 family.

10116:Akr1c3
gene id: 10116:Akr1c3
uniprot id: A6JLP6
uniprot id: P51652
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the aldo/keto reductase family.
messages: Catalyzes the conversion of progesterone into 20-alpha-dihydroprogesterone (20 alpha-OHP).
messages: Corpus luteum (large luteal cells).
messages: Cytoplasm
messages: Monomer.
messages: Remains repressed throughout pregnancy and becomes highly and rapidly expressed before parturition.
messages: Repressed by prolactin.
messages: The N-terminus is blocked.

10116:Slc24a4
gene id: 10116:Slc24a4
uniprot id: A0A0G2K0U1
uniprot id: A0A0G2K3S9
uniprot id: A6JEJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

10116:Gfpt1
gene id: 10116:Gfpt1
uniprot id: P82808
names: Activity Regulation
names: Function
names: Subunit
messages: Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes BMAL1 and CRY1 (PubMed:10898949). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and its effects on hyaluronan synthesis that occur during tissue remodeling (By similarity).
messages: Homotetramer, may also exist as homodimers.
messages: Inhibited by 4,4'-dithiodipyridine.

10116:C12h12orf43
gene id: 10116:C12h12orf43
uniprot id: A0A8I6AWB0
uniprot id: A6J1X6
uniprot id: Q5I034
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUSTOS family.
messages: Nucleus envelope
messages: Plays a role in the regulation of Wnt signaling pathway during early development.

10116:Sar1b
gene id: 10116:Sar1b
uniprot id: A6HE76
uniprot id: Q5HZY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. SAR1 family.
messages: Endoplasmic reticulum membrane
messages: GTP-binding protein involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex (By similarity). Synergizes with the cargo receptor SURF4 to mediate the export of lipoproteins from the endoplasmic reticulum, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis (By similarity).
messages: Golgi stack membrane
messages: Homodimer. Binds PREB. Part of the COPII coat complex. Binds to the cytoplasmic tails of target proteins in the endoplasmic reticulum (By similarity). Interacts with SURF4 (By similarity).

10116:Nhsl1
gene id: 10116:Nhsl1
uniprot id: A0A0G2JZL4
uniprot id: A0A8I5Y5X6
uniprot id: A0A8I6ASC1
uniprot id: A0A8I6GKL0
names: Similarity
messages: Belongs to the NHS family.

10116:St6galnac3
gene id: 10116:St6galnac3
uniprot id: Q64686
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 29 family.
messages: Golgi apparatus membrane
messages: In adults it is highly expressed in spleen, followed by kidney and lesser in lung. Not found in liver and skeletal muscle. In newborns it is abundantly expressed in brain and kidney.
messages: Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:8631773). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity (By similarity).

10116:Tnfsf13b
gene id: 10116:Tnfsf13b
uniprot id: A0A0G2K6C2
uniprot id: A6IWR7
uniprot id: A6IWR8
uniprot id: D3ZFD8
names: Similarity
messages: Belongs to the tumor necrosis factor family.

10116:Gpr27
gene id: 10116:Gpr27
uniprot id: A6IBG9
uniprot id: Q9JJH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed as a 3.0 kb transcript, in whole brain, hippocampus, striatum, frontal cortex, thalamus, pons and hypothalamus. A lower molecular weight transcript was detected in all regions examined, except the hypothalamus.
messages: Membrane
messages: Orphan receptor. Possible candidate for amine-like G-protein coupled receptor (By similarity).

10116:Crygb
gene id: 10116:Crygb
uniprot id: P10066
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: There are six different gamma crystallins identified in rat lens.

10116:Serpini1
gene id: 10116:Serpini1
uniprot id: A6J5Q7
uniprot id: Q9JLD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the serpin family.
messages: Detected in adult pituitary and adrenal gland.
messages: Perikaryon
messages: Secreted
messages: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
messages: secretory vesicle lumen

10116:Abcc6
gene id: 10116:Abcc6
uniprot id: O88269
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro) (By similarity). Transports also an anionic cyclopentapeptide endothelin antagonist, BQ-123 (PubMed:10692506). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity).
messages: Basal cell membrane
messages: Basolateral cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Deficient rats develop ectopic mineralization in the skin, eyes, and the arterial blood vessels. Plasma inorganic pyrophosphate (PPi) level is reduced by 70 % in deficient rats leading to a lowered PPi/Pi ratio.
messages: Glycosylated.
messages: Lateral cell membrane
messages: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis.
messages: Predominantly expressed in the liver and to a lesser extent in kidney, small intestine, and colon.

10116:Gabrg1
gene id: 10116:Gabrg1
uniprot id: A6JD87
uniprot id: P23574
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG1 sub-subfamily.
messages: Cell membrane
messages: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
messages: May be palmitoylated.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: This subunit carries the benzodiazepine binding site.

10116:Czib
gene id: 10116:Czib
uniprot id: A6JYT0
uniprot id: Q498R7
names: Domain
names: Similarity
names: Subunit
messages: Belongs to the UPF0587 family.
messages: Monomer.
messages: The N-terminal and the C-terminal half of the protein have a very similar 3D-structure, suggesting they arose from duplication. Requires a bound zinc ion for normal folding and solubility.

10116:Vom1r17
gene id: 10116:Vom1r17
uniprot id: A0A8I6A2U1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior.

10116:Srpra
gene id: 10116:Srpra
uniprot id: Q3KRC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:Kcnj13
gene id: 10116:Kcnj13
uniprot id: A6JWM8
uniprot id: O70617
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ13 subfamily.
messages: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.
messages: Membrane
messages: Phosphorylation at Ser-201 by PKC strongly inhibits ionic currents, while phosphorylation at Ser-287 by PKA increases them.

10116:Thumpd3
gene id: 10116:Thumpd3
uniprot id: A0A8I6A2Z6
uniprot id: A6IBN8
names: Similarity
messages: Belongs to the methyltransferase superfamily.

10116:Cav2
gene id: 10116:Cav2
uniprot id: Q2IBC5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: In the retina, mainly expressed in vessels, but also diffuse expression in the inner and outer plexiform layers and in the inner nuclear layer.
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.
messages: Monomer or homodimer (By similarity). Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR; the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19-phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation.
messages: Nucleus
messages: Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin.
messages: caveola

10116:Rab27b
gene id: 10116:Rab27b
uniprot id: A6IXZ5
uniprot id: Q99P74
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A (By similarity). Interacts (GDP-bound form preferentially) with DENND10 (By similarity).
messages: Late endosome
messages: Membrane
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Activated by GEFs such as DENND10.
messages: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes.

10116:Sec63
gene id: 10116:Sec63
uniprot id: A0A0G2JUJ9
uniprot id: A6K6Y0
uniprot id: D4A2Z6
names: Subcellular Location Annotation
messages: Membrane

10116:Edem1
gene id: 10116:Edem1
uniprot id: D3ZJE0
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

10116:Tjap1
gene id: 10116:Tjap1
uniprot id: A0A8I6GDP5
uniprot id: A6JIR8
uniprot id: D3ZU31
names: Subcellular Location Annotation
messages: Membrane

10116:Arpc3
gene id: 10116:Arpc3
uniprot id: A0A9K3Y7C4
uniprot id: B2GV73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

10116:Rpl36
gene id: 10116:Rpl36
uniprot id: P39032
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL36 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: cytosol

10116:Irf2bpl
gene id: 10116:Irf2bpl
uniprot id: Q5EIC4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the IRF2BP family.
messages: Expressed in the regions of the hypothalamus involved in reproductive control, such as medial preoptic area, arcuate nucleus and ventromedial nucleus.
messages: Interacts with CTNNB1.
messages: Nucleus
messages: Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins. Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway. Probably plays a role in the development of the central nervous system and in neuronal maintenance (By similarity). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter.
messages: Up-regulated during puberty in the hypothalamus, but not in the cerebral cortex.

10116:Tle5
gene id: 10116:Tle5
uniprot id: P63003
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Homooligomer and heterooligomer with other family members. Binds TCF7 and the NF-kappa-B subunit RELA. Interacts with PHF12. Interacts (via Q domain) with SIX3. Interacts with SIX6 (By similarity).
messages: Lacks the C-terminal WD repeats.
messages: Nucleus
messages: Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development (By similarity).
messages: Ubiquitinated by XIAP/BIRC4.

10116:Nek6
gene id: 10116:Nek6
uniprot id: B1H218
uniprot id: P59895
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Phosphorylation at Ser-206 is required for its activation. Phosphorylated upon IR or UV-induced DNA damage. Phosphorylated by CHEK1 and CHEK2. Interaction with APBB1 down-regulates phosphorylation at Thr-210 (By similarity).
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
messages: Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-108.
messages: Cytoplasm
messages: Displays an autoinhibited conformation: Tyr-108 side chain points into the active site, interacts with the activation loop, and blocks the alphaC helix. The autoinhibitory conformation is released upon binding with NEK9 (By similarity).
messages: Interacts with NEK9, predominantly in mitosis. Interacts with KIF11 (via C-terminus). Interacts with APBB1 (via WW domain). Interacts with ANKRA2, ATF4, ARHGAP33, CDC42, CIR1, PRAM1, PTN, PRDX3, PIN1, RAD26L, RBBP6, RPS7, STAT3 and TRIP4 (By similarity). Interacts with RPS6KB1.
messages: Nucleus
messages: Nucleus speckle
messages: Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (By similarity). Phosphorylates RPS6KB1 (PubMed:11516946). Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (By similarity).
messages: centrosome
messages: spindle pole

10116:Lmbr1
gene id: 10116:Lmbr1
uniprot id: A0A0G2K4B6
names: Similarity
messages: Belongs to the LIMR family.

10116:Asrgl1
gene id: 10116:Asrgl1
uniprot id: A6HZZ2
uniprot id: Q8VI04
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Ntn-hydrolase family.
messages: Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity.
messages: Cytoplasm
messages: Has both L-asparaginase and beta-aspartyl peptidase activity. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine (By similarity). May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions.
messages: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer (By similarity).
messages: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.
messages: In vasectomized rats, autoantibodies against Asrgl1 are present.
messages: Present in testis, brain, liver, kidney, heart and skeletal muscle. In brain, specifically present in the astrocytic lineage. Present in sperm (at protein level).

10116:Pcdhga8
gene id: 10116:Pcdhga8
uniprot id: I6LBX5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

10116:Fgg
gene id: 10116:Fgg
uniprot id: A6J5U7
uniprot id: A6J5U8
uniprot id: P02680
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
messages: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted
messages: Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

10116:Senp2
gene id: 10116:Senp2
uniprot id: A0A8L2PZM6
uniprot id: A6JS62
uniprot id: Q9EQE1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase C48 family.
messages: Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus (By similarity). Interacts with MTA1 (By similarity). Binds to AXIN1 (PubMed:10944533).
messages: Cytoplasm
messages: Nucleus membrane
messages: Polyubiquitinated; which leads to proteasomal degradation.
messages: Protease that catalyzes two essential functions in the SUMO pathway (By similarity). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (By similarity). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (By similarity). May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (PubMed:10944533, PubMed:11997515). Deconjugates SUMO2 from MTA1 (By similarity). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (By similarity). Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (By similarity).
messages: Ubiquitous. Highly expressed in brain, lung and testis.
messages: nuclear pore complex

10116:Thrb
gene id: 10116:Thrb
uniprot id: A6K040
uniprot id: A6K042
uniprot id: F1LQ07
uniprot id: Q3HW36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

10116:Kcne1
gene id: 10116:Kcne1
uniprot id: A6JLJ7
uniprot id: P15383
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:19219384). Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity).
messages: Apical cell membrane
messages: Belongs to the potassium channel KCNE family.
messages: By estrogen.
messages: Cell membrane
messages: Expressed in the heart (PubMed:2183220, PubMed:19219384). Expressed in kidney (PubMed:2344412). Expressed in estrogen-induced uterus (PubMed:2344412).
messages: Interacts with KCNB1 (PubMed:19219384). Interacts with KCNC2 (PubMed:14679187). Associates with KCNH2/HERG (By similarity). Interacts with KCNQ1; targets the complex KCNQ1-KCNE1 to the membrane raft (By similarity).
messages: Membrane
messages: Membrane raft
messages: Mutagenesis experiments were carried out by expressing in Xenopus oocytes the mutant Asn-77 either individually (homomultimers) or in combination with wild-type KCNE1 (heteromultimers) in a 1:1 ratio (PubMed:7605639).
messages: N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5.
messages: Phosphorylation inhibits the potassium current.

10116:Nfkbil1
gene id: 10116:Nfkbil1
uniprot id: Q8R2H1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CACTIN (via N-terminal domain); the interaction occurs in a pro-inflammatory-independent manner.
messages: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli (By similarity).
messages: Nucleus

10116:Dtx4
gene id: 10116:Dtx4
uniprot id: Q6TXG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

10116:Bard1
gene id: 10116:Bard1
uniprot id: Q9QZH2
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
messages: Homo- and heterodimer. Heterodimer (RING-type zinc finger) with BRCA1. Heterodimer (via ANK repeats and BRCT domains) with CSTF1/CSTF-50. Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts with UBXN1.
messages: Nucleus
messages: Processed during apoptosis. The homodimer is more susceptible to proteolytic cleavage than the BARD1/BRCA1 heterodimer.

10116:Ndufa6
gene id: 10116:Ndufa6
uniprot id: A6HT69
uniprot id: D4A3V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

10116:Hira
gene id: 10116:Hira
uniprot id: M0R4R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

10116:Emcn
gene id: 10116:Emcn
uniprot id: Q6AY82
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.
messages: Highly O-glycosylated. Sialic acid-rich glycoprotein (By similarity).
messages: Membrane

10116:LOC100174910
gene id: 10116:LOC100174910
uniprot id: A6IX72
uniprot id: G3V7R5
names: Similarity
messages: Belongs to the glutaredoxin family.

10116:Cldn14
gene id: 10116:Cldn14
uniprot id: A6KPY4
uniprot id: Q5BJQ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

10116:Uts2r
gene id: 10116:Uts2r
uniprot id: A6HLM8
uniprot id: P49684
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
messages: Membrane
messages: Preferentially expressed in neural and sensory tissues.

10116:Klrd1
gene id: 10116:Klrd1
uniprot id: O35778
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Can form disulfide-bonded heterodimer with NKG2 family members KLRC1 and KLRC2. KLRD1-KLRC1 heterodimer interacts with peptide-bound MHC-E-B2M heterotrimeric complex. KLRD1 plays a prominent role in directly interacting with MHC-E. KLRD1-KLRC1 interacts with much higher affinity with peptide-bound MHC-E-B2M than KLRD1-KLRC2. Interacts with the adapter protein TYROBP/DAP12; this interaction is required for cell surface expression and cell activation.
messages: Cell membrane
messages: Immune receptor involved in self-nonself discrimination. In complex with KLRC1 or KLRC2 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule MHC-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia and non-classical MHC class Ib molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Primarily functions as a ligand binding subunit as it lacks the capacity to signal.
messages: KLRD1-KLRC1 acts as an immune inhibitory receptor. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions. Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity. On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens. In MHC-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion. Upon MHC-E-peptide binding, transmits intracellular signals through KLRC1 immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHIP-1 and INPPL1/SHIP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules.
messages: KLRD1-KLRC2 acts as an immune activating receptor. On cytotoxic lymphocyte subsets recognizes MHC-E loaded with signal sequence-derived peptides from non-classical MHC class Ib MHC-G molecules, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon MHC-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation.

10116:Hrh1
gene id: 10116:Hrh1
uniprot id: P31390
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
messages: Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor down-regulation.

10116:Odf2l
gene id: 10116:Odf2l
uniprot id: A0A0G2K7F1
uniprot id: A0A8I5ZXN4
uniprot id: A6HWA6
uniprot id: A6HWA7
uniprot id: B2RYL6
uniprot id: G3V7S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

10116:Med23
gene id: 10116:Med23
uniprot id: A0A0H2UHV2
uniprot id: A0A8I6A9J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 23 family.
messages: Nucleus

10116:Slit2
gene id: 10116:Slit2
uniprot id: A0A0G2KA49
uniprot id: A0A8I6AMD5
uniprot id: F1MA79
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

10116:Eny2
gene id: 10116:Eny2
uniprot id: A0A8I5ZLL7
uniprot id: A6HRB0
uniprot id: A6HRB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

10116:Tox2
gene id: 10116:Tox2
uniprot id: Q76IQ7
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Highly expressed in ovary, where it is restricted to undifferentiated granulosa cells. Expressed in hypothalamus, pituitary gland, testis and uterus.
messages: Nucleus
messages: Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system.

10116:N6amt1
gene id: 10116:N6amt1
uniprot id: D4ACA2
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

10116:Gucy1a2
gene id: 10116:Gucy1a2
uniprot id: A6KQI9
uniprot id: Q9WVI4
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by nitric oxide in the presence of magnesium or manganese ions.
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm
messages: Has guanylyl cyclase on binding to the beta-1 subunit.
messages: Heterodimer of an alpha and a beta chain.
messages: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

10116:Slc8a3
gene id: 10116:Slc8a3
uniprot id: A0A8L2QN54
uniprot id: A6JDL8
uniprot id: P70549
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Calcium transport is down-regulated by Na(+) and stimulated by Ca(2+).
messages: Cell junction
messages: Cell membrane
messages: Detected in neurons in brain cortex and hippocampus. Detected in pyramidal cell bodies and processes, in granule cells and interneurons in the CA1 and CA3 region of the hippocampus. Detected on astrocyte processes in brain cortex. Detected on endothelial cells in hippocampus capillaries (at protein level) (PubMed:16914199). Restricted to brain and skeletal muscle (PubMed:8798769).
messages: Endoplasmic reticulum membrane
messages: Interacts with AKAP1.
messages: Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:8798769, PubMed:9486131). Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Required for normal oligodendrocyte differentiation and for normal myelination. Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Perikaryon
messages: The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium-regulated ion exchange.
messages: Up-regulated during in vitro differentiation of oligodendrocytes (at protein level).
messages: dendrite
messages: dendritic spine
messages: perinuclear region
messages: sarcolemma
messages: sarcoplasm

10116:Gpx7
gene id: 10116:Gpx7
uniprot id: A6JYU9
uniprot id: D3ZQI1
names: Similarity
messages: Belongs to the glutathione peroxidase family.

10116:Pdpn
gene id: 10116:Pdpn
uniprot id: Q64294
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the podoplanin family.
messages: Down-regulated in puromycin aminonucleoside nephrosis (PAN).
messages: Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity. Disialylated at Thr-52; sialic acid is critical for platelet-aggregating activity and for CLEC1B interaction (By similarity).
messages: Homodimer. Interacts with CLEC1B; the interaction is independent of CLEC1B glycosylation and activates CLEC1B; the interaction is dependent of sialic acid on O-glycans. Interacts with CD9; this interaction is homophilic and attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Interacts with LGALS8; the interaction is glycosylation-dependent; may participate in connection of the lymphatic endothelium to the surrounding extracellular matrix. Interacts with HSPA9. Interacts (via extracellular domain) with CD44; this interaction is required for PDPN-mediated directional migration and regulation of lamellipodia extension/stabilization during cell spreading and migration. Interacts (via cytoplasmic domain) with MSN and EZR; activates RHOA and promotes epithelial-mesenchymal transition. Interacts with CCL21; relocalized PDPN to the basolateral membrane.
messages: In adult kidney, expressed on the urinary surface and foot processes of podocytes and in parietal epithelial cells of Bowman's capsule where it is localized to luminal surfaces. In lung, expressed exclusively on luminal surfaces of type I alveolar epithelial cells and pleural mesothelial cells. Not expressed in type II alveolar cells. In bone, expressed in osteocytes and osteoblasts. In spleen, liver, stomach and intestine, expressed in mesoepithelium. Also expressed in thymic epithelial cells, choroid plexus and leptomeninges.
messages: In newborn kidney, not detected at the vesicle stage. First detected in S-shaped bodies.
messages: Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation. Interaction with CD9, on the contrary, attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Mediates effects on cell migration and adhesion through its different partners. Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness. Interaction with CD44 promotes directional cell migration in epithelial and tumor cells (By similarity). In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 activation through association with unknown transmembrane proteins. Engagement of CLEC1B by PDPN promotes FRCs relaxation by blocking lateral membrane interactions leading to reduction of ERM proteins (EZR; MSN and RDX) and MYL9 activation (By similarity). Through binding with LGALS8 may participate in connection of the lymphatic endothelium to the surrounding extracellular matrix. In keratinocytes, induces changes in cell morphology showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Controls invadopodia stability and maturation leading to efficient degradation of the extracellular matrix (ECM) in tumor cells through modulation of RHOC activity in order to activate ROCK1/ROCK2 and LIMK1/LIMK2 and inactivation of CFL1 (By similarity). Required for normal lung cell proliferation and alveolus formation at birth (By similarity). Does not function as a water channel or as a regulator of aquaporin-type water channels (By simi…
messages: Membrane
messages: Membrane raft
messages: The N-terminus is blocked.
messages: The cytoplasmic domain controls FRC elongation but is dispensable for contraction (By similarity). The cytoplasmic domain is essential for recruitment to invadopodia and ECM degradation (By similarity).
messages: filopodium membrane
messages: invadopodium
messages: lamellipodium membrane
messages: microvillus membrane
messages: ruffle membrane

10116:Pacsin1
gene id: 10116:Pacsin1
uniprot id: Q9Z0W5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PACSIN family.
messages: Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission.
messages: Cell membrane
messages: Cell projection
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Highly expressed in brain (at protein level).
messages: Homodimer. May form heterooligomers with other PACSINs. Interacts with MAPT. Interacts with TRPV4 (By similarity). Interacts (via SH3 domain) with SYNJ1 and WASL. Interacts (via SH3 domain) with DNM1; the interaction is reduced by DNM1 phosphorylation. Interacts with DNM2 and DNM3. Interacts with both COBL and DBNL. Identified in a complex composed of COBL, PACSIN1 and WASL. Interacts with EHD1 and EHD3.
messages: Membrane
messages: Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).
messages: Synapse
messages: The F-BAR domain forms a coiled coil and mediates membrane-binding and membrane tubulation. In the autoinhibited conformation, interaction with the SH3 domain inhibits membrane tubulation mediated by the F-BAR domain. DNM1 binding abolishes autoinhibition (By similarity).
messages: cytosol
messages: ruffle membrane
messages: synaptosome

10116:Dgcr6
gene id: 10116:Dgcr6
uniprot id: B0BNH6
uniprot id: F7FP83
names: Similarity
messages: Belongs to the gonadal family.

10116:mrpl24
gene id: 10116:mrpl24
uniprot id: A6J631
uniprot id: Q66H47
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

10116:Ppp2r2a
gene id: 10116:Ppp2r2a
uniprot id: A6K6P0
uniprot id: P36876
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the phosphatase 2A regulatory subunit B family.
messages: Brain.
messages: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). Interacts with TP53 (By similarity). Interacts with IER5 (By similarity). Interacts with MFHAS1; the interaction is direct (By similarity). Interacts with PABIR1/FAM122A (By similarity). Interacts with CRTC3 (By similarity).
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint.

10116:Il17re
gene id: 10116:Il17re
uniprot id: Q6AZ51
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Forms heterodimers with IL17RE; the heterodimer binds IL17C.
messages: Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling. Crucial regulator in innate immunity to bacterial pathogens (By similarity).

10116:Cox6a2
gene id: 10116:Cox6a2
uniprot id: A6I9Y9
uniprot id: G3V8M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

10116:Prdm9
gene id: 10116:Prdm9
uniprot id: P0C6Y7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Chromosome
messages: Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination. Can also methylate all four core histones with H3 being the best substrate and the most highly modified. Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate. During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity. Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression. During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema. EWSR1 joins PRDM9 with the chromosomal axis through REC8. In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation. Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation. In addition performs automethylation. Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation.
messages: Homodimer. Interacts with EHMT2 and CDYL; interaction only takes place when PRDM9 is bound to hotspot DNA. Interacts with CXXC1; this interaction does not link PRDM9-activated recombination hotspot sites with DSB machinery and is not required for the hotspot recognition pathway. Forms a complex with EWSR1, REC8, SYCP3 and SYCP1; complex formation is dependent of phosphorylated form of REC8 and requires PRDM9 bound to hotspot DNA; EWSR1 joins PRDM9 with the chromosomal axis through REC8.
messages: Mono-methylated; automethylated. Tri-methylated; automethylated. Mono-methylation is predominant; automethylation is lower and slower than H3 peptide methylation and is in a highest S-adenosyl-L-methionine concentration-dependent. There are two major sites for automethylation at Lys-372 and Lys-378. Lysines can be simultaneously methylated, such as Lys-372(me3)/Lys-376(me1), Lys-372(me1)/Lys-378(me1) and Lys-372(me1)/Lys-376(me1)/Lys-378(me1). Automethylation is an intramolecular (cis) process.
messages: Nucleus
messages: The C2H2-type zinc fingers determine the hotspot localization through its binding to specific DNA sequences. Variations in their sequence affect affinity towards DNA-binding motif.

10116:Ankrd34b
gene id: 10116:Ankrd34b
uniprot id: A6I4Q8
uniprot id: D3ZKP1
names: Similarity
messages: Belongs to the ANKRD34 family.

10116:Camsap3
gene id: 10116:Camsap3
uniprot id: A0A8I6AFS8
uniprot id: A0A8I6AHT4
uniprot id: A0A8I6G9R5
uniprot id: A6KQ12
uniprot id: D3ZXQ2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.
messages: cytoskeleton

10116:Emp2
gene id: 10116:Emp2
uniprot id: Q66HH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in glomeruli.
messages: Functions as a key regulator of cell membrane composition by regulating protein surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Regulates transepithelial migration of neutrophils into the alveolar lumen, potentially via mediation of cell surface expression of adhesion markers and lipid raft formation (By similarity). Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (By similarity). Facilitates surface trafficking and the formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (By similarity). Also regulates many processes through PTK2 (By similarity). Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (By similarity). Regulates cell migration and cell contraction through PTK2 and SRC activation (By similarity). Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 (By similarity). Positively regulates cell proliferation (By similarity). Plays a role during cell death and cell blebbing. Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (By similarity). Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (By similarity). Plays a role in placental angiogenesis and uterine natural killer cell regulation at the maternal-fetal placental interface, however not required in the maternal tissues for a viable pregnancy (By similarity). Involved in the early stages of embry…
messages: Golgi apparatus membrane
messages: Interacts with PTK2; regulates PTK2 activation and localization (By similarity). Interacts with ITGB3; regulates the levels of the heterodimer ITGA5-ITGB3 integrin surface expression (By similarity). Interacts with P2RX7 (via C-terminus) (By similarity). Interacts with ITGB1; the interaction may be direct or indirect and ITGB1 has a heterodimer form (By similarity).
messages: Membrane raft
messages: Nucleus
messages: perinuclear region

10116:Pik3cd
gene id: 10116:Pik3cd
uniprot id: A6IUB9
uniprot id: D4A5Q1
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

10116:Stx1b
gene id: 10116:Stx1b
uniprot id: A6I9V0
uniprot id: P61265
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type C (BoNT/C), which hydrolyzes the 252-Lys-|-Ala-253 bond (PubMed:7737992). Cleavage inhibits neurotransmitter release (PubMed:7901002).
messages: Belongs to the syntaxin family.
messages: Cerebral cortex, hippocampus, cerebellum, and adrenal medulla.
messages: Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca(2+)-dependent (By similarity).
messages: Membrane
messages: Phosphorylated by CK2.
messages: Potentially involved in docking of synaptic vesicles at presynaptic active zones (PubMed:7901002). May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity).

10116:Ints12
gene id: 10116:Ints12
uniprot id: A0A0H2UHJ4
uniprot id: A6HVU5
uniprot id: Q68FR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
messages: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.
messages: Nucleus

10116:Arl6
gene id: 10116:Arl6
uniprot id: A0A8I6ACB6
uniprot id: A0A8J8YB99
uniprot id: A6IQI5
uniprot id: B1WC73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

10116:Olr1233
gene id: 10116:Olr1233
uniprot id: A0A8I5ZK27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tas2r105
gene id: 10116:Tas2r105
uniprot id: A6IMA1
uniprot id: Q9JKT5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Expressed in the duodenum, antrum and fundus (part of the stomach).
messages: Gustducin-coupled cycloheximide receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
messages: Membrane
messages: Several bitter taste receptors are expressed in a single taste receptor cell.

10116:Akr7a2
gene id: 10116:Akr7a2
uniprot id: Q8CG45
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
messages: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. Acts as a 2-carboxybenzaldehyde reductase.
messages: Cytoplasm
messages: Golgi stack
messages: Homodimer. Heterodimer with AKR7A1.
messages: Mitochondrion
messages: With 4-nitrobenzaldehyde as substrate, it exhibits a substantially greater specific activity with NADPH than with NADH. Conversely, it has a 1.8-fold higher activity towards succinic semialdehyde with NADH than with NADPH.

10116:Tmem45b
gene id: 10116:Tmem45b
uniprot id: A6JYG6
uniprot id: Q497B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Plays a role in innate immunity.
messages: trans-Golgi network membrane

10116:Hsd11b1
gene id: 10116:Hsd11b1
uniprot id: P16232
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Controls the reversible conversion of biologically active glucocorticoids such as 11-dehydrocorticosterone to corticosterone using NADP(H) (PubMed:12460758, PubMed:8613810, PubMed:14973125). Participates in the corticosteroid receptor-mediated anti-inflammatory response, as well as metabolic and homeostatic processes (By similarity). Bidirectional in vitro, predominantly functions as a reductase in vivo, thereby increasing the concentration of active glucocorticoids (PubMed:12460758). It has broad substrate specificity, besides glucocorticoids, it accepts other steroid and sterol substrates (PubMed:14973125). Interconverts 7-oxo- and 7-hydroxy-neurosteroids such as 7-oxopregnenolone and 7beta-hydroxypregnenolone, 7-oxodehydroepiandrosterone (3beta-hydroxy-5-androstene-7,17-dione) and 7beta-hydroxydehydroepiandrosterone (3beta,7beta-dihydroxyandrost-5-en-17-one), among others (By similarity). Catalyzes the stereo-specific conversion of the major dietary oxysterol, 7-ketocholesterol (7-oxocholesterol), into the more polar 7-beta-hydroxycholesterol metabolite (PubMed:14973125). 7-oxocholesterol is one of the most important oxysterols, it participates in several events such as induction of apoptosis, accumulation in atherosclerotic lesions, lipid peroxidation, and induction of foam cell formation (By similarity). Mediates the 7-oxo reduction of 7-oxolithocholate mainly to chenodeoxycholate, and to a lesser extent to ursodeoxycholate, both in its free form and when conjugated to glycine or taurine, providing a link between glucocorticoid activation and bile acid metabolism (By similarity). Catalyzes the synthesis of 7-beta-25-dihydroxycholesterol from 7-oxo-25-hydroxycholesterol in vitro, which acts as ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (By similarity).
messages: Endoplasmic reticulum membrane
messages: Expression of both isoforms is found in 1 week-old rats. Expression increases exponentially up to 4 weeks but after this time there is no further increase up to 16 weeks.
messages: Glycosylated.
messages: Homodimer.
messages: Kidney-specific.
messages: Liver, kidney, lung and testis (PubMed:2808402). Brain (PubMed:2387261). Expressed in liver (at protein level) (PubMed:21453287).

10116:S100b
gene id: 10116:S100b
uniprot id: P04631
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain (By similarity). The S100B dimer binds two molecules of STK38 (By similarity). Interacts with CACYBP in a calcium-dependent manner (PubMed:12042313). Interacts with ATAD3A; this interaction probably occurs in the cytosol prior to ATAD3A mitochondrial targeting (PubMed:20351179). Interacts with S100A6 (By similarity). The S100B dimer interacts with two molecules of CAPZA1 (PubMed:12470955). Interacts with AGER (PubMed:19910580). Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity (By similarity). Interacts with TPPP; this interaction inhibits TPPP dimerization (By similarity). Interacts with isoform CLSTN3beta of CLSTN3; interaction promotes secretion (By similarity).
messages: Nucleus
messages: Secreted
messages: Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain (PubMed:20351179, PubMed:14621986, PubMed:15823027, PubMed:18949447). Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer (PubMed:15823027). Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites (By similarity). Acts as a neurotrophic factor that promotes astrocytosis and axonal proliferation (By similarity). Involved in innervation of thermogenic adipose tissue by acting as an adipocyte-derived neurotrophic factor that promotes sympathetic innervation of adipose tissue (By similarity). Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase (By similarity). Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (PubMed:19910580). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity). May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (By similarity).
messages: Up-regulated in periinfarct ventricular myocardium.

10116:Lrp6
gene id: 10116:Lrp6
uniprot id: A6IMD1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Dlx2
gene id: 10116:Dlx2
uniprot id: A6HM54
uniprot id: G3V668
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

10116:Cacng2
gene id: 10116:Cacng2
uniprot id: Q71RJ2
uniprot id: Q99PR9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Phosphorylation of Thr-321 by PKA impairs interaction with DLG1 and DLG4.
messages: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
messages: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97 (PubMed:27756895). May interact with GOPC (By similarity). Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with GRIA1 and GRIA2 (PubMed:27756895). Interacts with MPP2 (PubMed:27756895).
messages: synaptosome

10116:LOC691113
gene id: 10116:LOC691113
uniprot id: A0A8I6AJH9
names: Similarity
messages: Belongs to the UPF0561 family.

10116:Olr1245
gene id: 10116:Olr1245
uniprot id: A6KUF1
uniprot id: M0RDS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ankrd54
gene id: 10116:Ankrd54
uniprot id: Q566C8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts (via ankyrin repeat region) with LYN (via SH3-domain) in an activation-independent status of LYN. Forms a multiprotein complex with LYN and HCLS1 (By similarity). Interacts with TSN2, VAV1, DBNL and LASP1 (By similarity).
messages: Midbody
messages: Nucleus
messages: Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.

10116:Pex6
gene id: 10116:Pex6
uniprot id: A6JIM9
uniprot id: P54777
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.
messages: Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers. Interacts with PEX26; interaction is direct and promotes recruitment to peroxisomal membranes. Interacts with ZFAND6.
messages: Peroxisome membrane
messages: cytosol
messages: photoreceptor outer segment

10116:Cacng6
gene id: 10116:Cacng6
uniprot id: A6KS36
uniprot id: A6KS37
uniprot id: Q8VHW7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Cell membrane
messages: Detected in heart atrium and ventricle, aorta and skeletal muscle (PubMed:11738816). Detected in heart left ventricle (PubMed:21127204).
messages: Interacts with CACNA1C. Identified in a complex with the L-type calcium channel subunits CACNA1C, CACNA2D1 and either CACNB1 or CACNB2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.

10116:Defb5
gene id: 10116:Defb5
uniprot id: Q32ZI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

10116:Or10j5
gene id: 10116:Or10j5
uniprot id: A6JG74
uniprot id: D3ZB83
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Slc12a1
gene id: 10116:Slc12a1
uniprot id: A6HPW2
uniprot id: F7EUW9
uniprot id: G3V6U1
uniprot id: Q5PQV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

10116:Mrpl52
gene id: 10116:Mrpl52
uniprot id: A6KGT5
uniprot id: B2RYV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL52 family.
messages: Mitochondrion

10116:Sez6
gene id: 10116:Sez6
uniprot id: A0A8I5ZN57
uniprot id: A0A8I5ZRZ3
uniprot id: F1MA42
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Gfus
gene id: 10116:Gfus
uniprot id: A6HS39
uniprot id: B0BNN0
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

10116:RT1-CE16
gene id: 10116:RT1-CE16
uniprot id: A0A2P1NRY6
uniprot id: Q6MG28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Involved in the presentation of foreign antigens to the immune system.
messages: Membrane

10116:Kng1
gene id: 10116:Kng1
uniprot id: P08932
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: As T-kinin is preceded by a Met instead of an Arg or Lys, it is not released from its precursor by either tissue or plasma kallikrein.
messages: In response to an inflammatory stimulant. T-kininogen II synthesis is induced and the plasma concentration of T-kininogen I is raised.
messages: Kininogens are plasma glycoproteins with a number of functions: (1) as precursor of the active peptide bradykinin they effect smooth muscle contraction, induction of hypotension and increase of vascular permeability. (2) They play a role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII. (3) They are inhibitor of thiol proteases.
messages: Plasma.
messages: Rats express four types of kininogens: the classical HMW and LMW kininogens produced by alternative splicing of the same gene, and two additional LMW-like kininogens: T-I and T-II.
messages: extracellular space

10116:Rnase9
gene id: 10116:Rnase9
uniprot id: F7FI09
uniprot id: Q5QJV4
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

10116:Trmt13
gene id: 10116:Trmt13
uniprot id: B2GV29
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

10116:Wnt10b
gene id: 10116:Wnt10b
uniprot id: A0A0G2K6Q8
uniprot id: A6KCA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

10116:Ier5l
gene id: 10116:Ier5l
uniprot id: Q5PQP0
names: Similarity
messages: Belongs to the IER family.

10116:Fam118a
gene id: 10116:Fam118a
uniprot id: B5DFD4
uniprot id: F7FDN4
names: Similarity
messages: Belongs to the FAM118 family.

10116:Prl2c1
gene id: 10116:Prl2c1
uniprot id: Q1KZI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

10116:Tec
gene id: 10116:Tec
uniprot id: B2RYC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

10116:Kcng2
gene id: 10116:Kcng2
uniprot id: A6K5H5
uniprot id: Q9QYU3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily.
messages: Heterodimer with KCNB1. Does not form homomultimers (By similarity).
messages: Highly expressed in heart, in particular in right and left atrium, and detected at lower levels in the right and left ventricle.
messages: Membrane
messages: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (By similarity).
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

10116:Pcsk7
gene id: 10116:Pcsk7
uniprot id: A6J459
uniprot id: Q62849
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase S8 family.
messages: Inhibited by zinc and copper.
messages: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.
messages: Widely expressed. Highly expressed in colon and spleen.
messages: trans-Golgi network membrane

10116:Slc12a4
gene id: 10116:Slc12a4
uniprot id: A0A8I5ZKL7
uniprot id: A6IYV0
uniprot id: Q63632
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Homodimer. Heteromultimer with other K-Cl cotransporters.
messages: Inhibited by WNK3.
messages: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10347194). May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (Probable).
messages: Membrane
messages: N-glycosylated.
messages: Phosphorylated, phosphorylation may regulate transporter activity.
messages: Ubiquitous.

10116:Vom2r31
gene id: 10116:Vom2r31
uniprot id: Q9QWK0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Jtb
gene id: 10116:Jtb
uniprot id: O88823
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the JTB family.
messages: Cytoplasm
messages: Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B (By similarity).
messages: Membrane
messages: Mitochondrion
messages: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
messages: centrosome
messages: spindle

10116:Cd46
gene id: 10116:Cd46
uniprot id: A0A8I5ZMW2
uniprot id: A0A8L2QSL3
uniprot id: A6JH46
uniprot id: Q9Z0M4
names: Caution
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Interacts with C3b. Interacts with C4b. Interacts with moesin/MSN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in the fusion of the spermatozoa with the oocyte during fertilization.
messages: N-glycosylated.
messages: Not expressed in embryonic and immature rats. Expressed in parallel with synthesis of spermatids.
messages: O-glycosylated.
messages: Specifically expressed in testis. Within testis, present only in elongated spermatids and spermatozoa (at protein level).
messages: acrosome inner membrane

10116:Sec61a1
gene id: 10116:Sec61a1
uniprot id: A6IB45
uniprot id: P61621
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (By similarity). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity).
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (By similarity). The SEC61 channel associates with the multi-pass translocon (MPT) complex (By similarity).

10116:Vezt
gene id: 10116:Vezt
uniprot id: A0A8L2QL87
uniprot id: A6IFZ9
uniprot id: Q5XI52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Interacts with USH2A (via the cytoplasmic region); the interaction associates VEZT with the USH2 complex at the stereocilia base (By similarity). Interacts with myosin MYO7A and the cadherin-catenins complex (By similarity).
messages: Membrane
messages: Nucleus
messages: Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process.
messages: acrosome
messages: adherens junction
messages: stereocilium membrane

10116:Ucp3
gene id: 10116:Ucp3
uniprot id: A6I6N5
uniprot id: P56499
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with HAX1; the interaction is direct and calcium-dependent.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism. Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis. However, this function is controversial and uncoupling may not be the function, or at least not the main function, but rather a consequence of more conventional metabolite transporter activity.

10116:Epo
gene id: 10116:Epo
uniprot id: A6J027
uniprot id: P29676
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the EPO/TPO family.
messages: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
messages: Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.
messages: Secreted

10116:Cpne1
gene id: 10116:Cpne1
uniprot id: D4A1R8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the copine family.
messages: C2 domains are necessary for calcium-dependent cell membrane association. C2 domains are necessary for neuronal progenitor cell differentiation in a calcium-independent manner.
messages: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in liver, brain, heart, intestine, kidney and lung (at protein level) (PubMed:11123945).
messages: Homodimer; homodimerizes via its C2 domains. Interacts with p65/RELA (via N-terminus); this interaction induces proteolytic cleavage of p65/RELA subunit and inhibition of NF-kappa-B transcriptional activity. Interacts (via VWFA domain) with ACTB, CCDC22, MYCBP2, PPP5C, RDX and UBE2O.
messages: Nucleus

10116:Gjb1
gene id: 10116:Gjb1
uniprot id: A0A654IET2
uniprot id: P08033
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

10116:Myo5a
gene id: 10116:Myo5a
uniprot id: Q9QYF3
names: Disease Annotation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Defects in Myo5a are a cause of Dilute-opisthotonus (dop). Dop rats have diluted coat color and are occasionally associated with severe neurological disorders.
messages: May be a homodimer, which associates with multiple calmodulin or myosin light chains (By similarity). Interacts with RIPL2, the interaction is required for its role in dendrite formation (PubMed:19812310). Interacts with MLPH. Interacts with SYTL4 (By similarity). Interacts with MYRIP (By similarity). Interacts with RAB10; mediates the transport to the plasma membrane of SLC2A4/GLUT4 storage vesicles (By similarity). Interacts with FMR1; this interaction occurs in association with polyribosome (By similarity).
messages: Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.

10116:Pgk2
gene id: 10116:Pgk2
uniprot id: A0A8I5ZS38
uniprot id: Q5XIV1
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

10116:Fez1
gene id: 10116:Fez1
uniprot id: A6KRM5
uniprot id: P97577
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the zygin family.
messages: Brain.
messages: Cell membrane
messages: Homodimer. Interacts with UBE4B and SAP30L (By similarity). Interacts with SCOC and ULK1; SCOC interferes with ULK1-binding to FEZ1 (By similarity). Directly interacts with SCOC and UVRAG. Stabilizes the interaction between SCOC and UVRAG during amino acid starvation (By similarity). Interacts with the NH2-terminal variable region (V1) of PKC zeta and weakly with that of PKC epsilon.
messages: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules.
messages: Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination.
messages: Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26 (By similarity).
messages: centrosome

10116:Calr
gene id: 10116:Calr
uniprot id: A6IY70
uniprot id: P18418
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Associates with PDIA3 through the tip of the extended arm formed by the P-domain.
messages: Belongs to the calreticulin family.
messages: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity).
messages: Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity (By similarity).
messages: Cell surface
messages: Cortical granule
messages: Cytolytic granule
messages: Endoplasmic reticulum lumen
messages: Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with GABARAP, NR3C1 and TRIM21. Interacts with PPIB and SPACA9. Interacts (via P-domain) with PDIA5 (By similarity). Interacts with PDIA3/ERp57 (PubMed:11842220). Interacts with CLCC1 (By similarity).
messages: Predentin and odontoblast.
messages: Sarcoplasmic reticulum lumen
messages: The interaction with glycans occurs through a binding site in the globular lectin domain.
messages: The zinc binding sites are localized to the N-domain.
messages: Was originally (Ref.9) thought to be D-beta-hydroxybutyrate dehydrogenase.
messages: cytosol
messages: extracellular matrix

10116:Zfp384
gene id: 10116:Zfp384
uniprot id: Q9EQJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Expressed in osteocytes, osteoblasts, and chondrocytes in bone.
messages: Interacts with BCAR1.
messages: Nucleus
messages: Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1.

10116:Mrgprx1
gene id: 10116:Mrgprx1
uniprot id: A0A096MIT0
uniprot id: Q8R4G1
uniprot id: W8W3G5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
messages: Cell membrane
messages: Membrane
messages: Orphan receptor activated by neuropeptides terminating in Arg-Phe or Arg-Phe-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. May regulate the function of nociceptive neurons by modulation of pain perception (By similarity).
messages: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. Associated preferentially with IB4 class of small-diameter somatosensory afferents (also known as nociceptors).

10116:Nop16
gene id: 10116:Nop16
uniprot id: B0BMU2
uniprot id: Q1RP77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

10116:Rnf43
gene id: 10116:Rnf43
uniprot id: A0A8I6AML0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane

10116:Nkx2-5
gene id: 10116:Nkx2-5
uniprot id: O35767
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NK-2 homeobox family.
messages: Homodimer (via the homeobox); binds DNA as homodimer. Interacts (via the homeobox) with TBX5 (via the T-box); this complex binds DNA. Interacts with HIPK1 and HIPK2, but not HIPK3. Interacts with the C-terminal zinc finger of GATA4 through its homeobox domain. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with FBLIM1. Interacts with TBX18. Interacts with histone methyltransferase NSD2 (via HMG box) (By similarity). Interacts with NEDD9 (By similarity). Interacts with TBX1 (By similarity).
messages: Nucleus
messages: The homeobox domain binds to double-stranded DNA.
messages: Transcription factor required for the development of the heart and the spleen (By similarity). During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4 (By similarity). May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). Binds to the core DNA motif of NPPA promoter. Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (By similarity). Positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia (By similarity).

10116:Prkx
gene id: 10116:Prkx
uniprot id: Q5BK52
names: Similarity
messages: Belongs to the protein kinase superfamily.

10116:Or1n2
gene id: 10116:Or1n2
uniprot id: A6JUI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Plce1
gene id: 10116:Plce1
uniprot id: Q99P84
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by the heterotrimeric G-protein subunits GNA12, GNA13 and GNB1-GNG2. Activated by HRAS, RAP1A, RHOA, RHOB, RHOC, RRAS and RRAS2. Activated by the G(s)-coupled GPCRs ADRB2, PTGER1 and CHRM3 through cyclic-AMP formation and RAP2B activation. Inhibited by G(i)-coupled GPCRs.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Interacts with RHOA (PubMed:12900402). Interacts with GTP-bound HRAS, RAP1A, RAP2A, RAP2B and RRAS (By similarity). Interacts with IQGAP1 (PubMed:17086182). Interacts with AVIL (By similarity).
messages: The Ras-GEF domain has a GEF activity towards HRAS and RAP1A. Mediates activation of the mitogen-activated protein kinase pathway (By similarity).
messages: The Ras-associating domain 1 is degenerated and may not bind HRAS (By similarity). The Ras-associating domain 2 mediates interaction with GTP-bound HRAS, RAP1A and probably RAP2A and RAP2B and recruitment of HRAS to the cell membrane.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly (By similarity).
messages: Ubiquitously expressed. Detected in glomerular podocytes (at protein level).
messages: cytosol
messages: lamellipodium

10116:Repin1
gene id: 10116:Repin1
uniprot id: Q68H95
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimers and homomultimers. Found in a complex with RIP60 and RIP100 (By similarity).
messages: Nucleus
messages: Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone. Facilitates DNA bending (By similarity).

10116:Tmsb4x
gene id: 10116:Tmsb4x
uniprot id: P62329
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the thymosin beta family.
messages: By NGF and fibroblast growth factors.
messages: Interacts with SERPINB1. Identified in a complex composed of ACTA1, COBL, GSN and TMSB4X (By similarity).
messages: Originally found in thymus but it is widely distributed in many tissues.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).
messages: Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.
messages: cytoskeleton

10116:Tbx3
gene id: 10116:Tbx3
uniprot id: A0A0G2K8D7
uniprot id: A6J1K4
uniprot id: Q7TST9
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PML.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Transcriptional repressor involved in developmental processes (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (By similarity). Probably plays a role in limb pattern formation (By similarity). Required for mammary placode induction, involved in maintenance of the mammary buds during development and branching morphogenesis in embryonic and adult glands; partially redundant with TBX2 (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (By similarity).

10116:Plpp6
gene id: 10116:Plpp6
uniprot id: Q66H88
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Endoplasmic reticulum membrane
messages: Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates. Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation. May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway. May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins. Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols. May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate.
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Phosphorylation by PKC activates the phosphatase activity towards presqualene diphosphate.

10116:Asic2
gene id: 10116:Asic2
uniprot id: A6HHC7
uniprot id: A6HHC8
uniprot id: Q62962
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Appears just before birth, reaches maximum levels after birth, then declines slightly until adulthood.
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily.
messages: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Activation by an extracellular pH drop is followed by a rapid pH-independent inactivation. Heteromeric channel assembly seems to modulate channel properties.
messages: Cell membrane
messages: Expressed in sciatic nerve and dorsal root ganglion (DRG) (at protein level). Both isoforms display the same expression pattern except in DRG where isoform 2 is more abundantly expressed. Widely distributed throughout the brain. Highly expressed in the main olfactory bulb, neo- and allo-cortical regions, hippocampal formation, habenula, basolateral amygdaloid nuclei, and cerebellum. In the olfactory system, expressed in the glomerular cell layer, the internal granular layer, and the mitral and internal plexiform cell layers. Within the glomerular layer, restricted to the periglomerular cells. In the neocortex, strongly expressed in the large pyramidal neurons in all cortical layers as well as in the oligo-, astro-, or micro-glia cells. In the hippocampal formation, expressed in dentate granule cells and hilar neurons, as well as in pyramidal cells of CA1-CA3 subfields. Expressed in stratum oriens and radiatum of all subfields. Within the thalamus, expressed moderately in the medial and lateral habenula. In the cerebellar cortex expressed in Purkinje cells and granule cells. Expressed at low levels in choroid plexus.
messages: Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with PRKCABP (By similarity). Interacts with STOM; this regulates channel activity. Interacts with ASIC1. Isoform 2 interacts with ASIC3. Heterotrimer of Asic1a-Asic2a interacts with the snake venom mambalgin-1, mambalgin-2 and mambalgin-3 (PubMed:23034652, PubMed:23624383). Heterotrimer of Asic1a-Asic2b interacts with the snake venom mambalgin-1 and mambalgin-2 (PubMed:23034652).
messages: Membrane
messages: Regulated by Zn(2+). Inhibited by anti-inflammatory drugs like salicylic acid.
messages: Seems to be inactive as monomer or in a monomeric assembly and is not activated by mutagenesis of Gly-430. Mutagenesis of Ser-60 into Gly reduces activation by PKC through PRKCABP/PICK-1 of a ASIC3/ACCN3-ASIC2/ASIC2b channel.
messages: Up-regulation upon tissues inflammation is abolished by anti-inflammatory drugs.

10116:Bmf
gene id: 10116:Bmf
uniprot id: Q8K589
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Bcl-2 family.
messages: Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2 (By similarity).
messages: May play a role in apoptosis.

10116:Fdps
gene id: 10116:Fdps
uniprot id: A6J6C0
uniprot id: P05369
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the FPP/GGPP synthase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer. Interacts with RSAD2 (By similarity).
messages: Inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell (By similarity).
messages: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity).
messages: Testis, liver, kidney, brain and adrenal gland.

10116:Or1j13b
gene id: 10116:Or1j13b
uniprot id: D3ZIL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Pik3cb
gene id: 10116:Pik3cb
uniprot id: A6I2C5
uniprot id: G3V839
uniprot id: Q9Z1L0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylation at Ser-1070 negatively regulates the phosphatidylinositol-4,5-bisphosphate 3-kinase activity.
messages: Belongs to the PI3/PI4-kinase family.
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit PIK3CB and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interaction with PIK3R2 is required for nuclear localization and nuclear export (By similarity). Part of a complex with PIK3R1 and PTEN (By similarity). Binding to PTEN may antagonize the lipid kinase activity under normal growth conditions (By similarity). Part of a complex involved in autophagosome formation composed of PIK3C3 and PIK3R4 (By similarity). Interacts with BECN1, ATG14 and RAB5A (By similarity).
messages: Nucleus
messages: Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Has also a protein kinase …
messages: The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1; the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1; and the PI3K/PI4K kinase domain with the cSH2 (C-terminal SH2) region of PIK3R1. The inhibitory interaction between the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1 is weak. The nuclear localization signal (NLS) is required for its function in cell survival (By similarity).

10116:Or5h27
gene id: 10116:Or5h27
uniprot id: A0A0G2K9X4
uniprot id: A6IQJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Copb1
gene id: 10116:Copb1
uniprot id: A6I897
uniprot id: P23514
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Brefeldin A induces dissociation from the Golgi of the beta-COP and presumably the other coatomer subunits.
messages: COPI-coated vesicle membrane
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Microsome membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with SCYL1. Interacts with CAPN8 (By similarity). Interacts with COPG1 (By similarity). Interacts with ARF1 (myristoylated); this interaction is required for binding of COPB1 to Golgi membranes (By similarity). Interacts (via trunk domain) with ARF1 (via switch I region); the interaction is direct (By similarity). Interacts with KCNK2 (via N-terminus); this interaction increases the channel-mediated whole cell currents and promotes plasma membrane expression of KCNK2 (By similarity). Interacts with PRKCE. Interacts with STX17. Interacts with TMEM115 (By similarity). Interacts with TMEM41B (By similarity).
messages: Proteolytically cleaved between Ser-528 and Ser-529 by CAPN8.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins in the axonal compartment of dorsal root ganglion (DRG) cells. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis.

10116:Samd4b
gene id: 10116:Samd4b
uniprot id: A6J9J0
uniprot id: D4A769
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAUG family.
messages: Cytoplasm

10116:Grb7
gene id: 10116:Grb7
uniprot id: A0A8L2Q3T0
uniprot id: Q9QZC5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).
messages: Belongs to the GRB7/10/14 family.
messages: Cell membrane
messages: Cell projection
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Detected in liver, kidney and placenta, and at lower levels in lung.
messages: Homodimer. Interacts (via SH2 domain) with EGFR, ERBB2, ERBB3 (when phosphorylated), ERBB4 (when phosphorylated), EPHB1, INSR, FGFR1, PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Interacts with SHC1. Interacts with RND1. Interacts (when tyrosine phosphorylated) with FHL2 and HAX1 (By similarity). Interacts (via SH2 domain) with RET and PTK2/FAK1. Interacts (when not phosphorylated) with ELAVL1. In stressed cells, but not in normal cells, part of a complex that contains at least GRB7, PTK2/FAK1, STAU1, ELAVL1 and TIA1. Interacts (via SH2 domain) with KIT (phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity).
messages: Phosphorylated on serine and threonine residues in response to activation of receptor kinases. Phosphorylated on tyrosine residues by TEK/TIE2. Phosphorylated on tyrosine residues by PTK2/FAK1, and possibly also other kinases. Phosphorylation is enhanced by activation of receptor kinases by a cognate ligand. Tyrosine phosphorylation is essential for activation of down-stream protein kinases. Phosphorylation decreases affinity for target mRNA molecules (By similarity).
messages: The PH domain mediates interaction with membranes containing phosphoinositides.
messages: focal adhesion

10116:Mmp21
gene id: 10116:Mmp21
uniprot id: A6HX23
uniprot id: D3ZZ42
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

10116:Scart1
gene id: 10116:Scart1
uniprot id: A6HXH9
uniprot id: D4AEN2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Zfpm1
gene id: 10116:Zfpm1
uniprot id: A6IZR2
names: Subcellular Location Annotation
messages: Nucleus

10116:Itk
gene id: 10116:Itk
uniprot id: A6HDR3
uniprot id: D4A7W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

10116:Or5t5b
gene id: 10116:Or5t5b
uniprot id: A0A8I5Y0J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Hmgb3
gene id: 10116:Hmgb3
uniprot id: B0BN99
uniprot id: F7EWK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

10116:Rpl23
gene id: 10116:Rpl23
uniprot id: A6HIM8
uniprot id: P62832
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

10116:Mup4
gene id: 10116:Mup4
uniprot id: A0A8I6A4R9
uniprot id: A6KDY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

10116:Aup1
gene id: 10116:Aup1
uniprot id: A1L134
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AUP1 family.
messages: Endoplasmic reticulum membrane
messages: Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1 (By similarity). Interacts with the cytoplasmic tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM (By similarity). Interacts (via C-terminus) with UBE2G2; the interaction recruits UBE2G2 to lipid droplets (By similarity). Interacts with ubiquitin ligases AMFR/gp78 and RNF139/TRC8; this promotes interaction of UBE2G2 with AMFR and RNF139 (By similarity). Interacts with apolipoprotein APOB (By similarity).
messages: Lipid droplet
messages: Monoubiquitinated and diubiquitinated.
messages: Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (By similarity). Plays a role in lipid droplet formation (By similarity). Induces lipid droplet clustering (By similarity). Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation (By similarity). Also required for the degradation of INSIG1, SREBF1 and SREBF2 (By similarity). Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB (By similarity).
messages: The CUE domain is required for interaction with the ER quality control machinery and misfolded substrates, ubiquitination, lipid clustering and interaction with AMFR but is not required for localization to lipid droplets.

10116:Fto
gene id: 10116:Fto
uniprot id: B4F7E0
uniprot id: Q2A121
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by ascorbate. Inhibited by N-oxalylglycine, fumarate and succinate.
messages: Belongs to the fto family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. May also exist as homodimer.
messages: Nucleus
messages: Nucleus speckle
messages: RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. M6A demethylation by FTO affects mRNA expression and stability. Also able to demethylate m6A in U6 small nuclear RNA (snRNA). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA. Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping. Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Ability to repair alkylated DNA and RNA is however unsure in vivo. Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation. Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (By similarity). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity).
messages: The 3D-structure of the Fe2OG dioxygenase domain is similar to that of the Fe2OG dioxygenase domain found in the bacterial DNA repair dioxygenase alkB and its mammalian orthologs, but sequence similarity is very low. As a consequence, the domain is not detected by protein signature databases.
messages: Ubiquitous (PubMed:17143547, PubMed:18218688). Highly expressed in teeth and weakly in bone (PubMed:17143547).
messages: Up-regulated in the hypothalamus after 48 hours fasting.

10116:Cstpp1
gene id: 10116:Cstpp1
uniprot id: A0A8I5ZL69
uniprot id: Q5M9F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSTPP1 family.
messages: Interacts with PCM1. Interacts with TTLL1, TPGS1, TPGS2 and LRRC49; the interactions link CSTPP1 to the complex TPGC. Binds to alpha-tubulin.
messages: Regulator of the tubulin polyglutamylase complex (TPGC) that controls cytoskeletal organization, nuclear shape, and cilium disassembly by balancing microtubule and actin assembly. Regulates the assembly and stability of the TPGC and thereby modulates polyglutamylation of the microtubule, which antagonizes MAP4 binding.
messages: centriolar satellite
messages: cytoskeleton

10116:Sumo1
gene id: 10116:Sumo1
uniprot id: A6IPB1
uniprot id: Q5I0H3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cell membrane
messages: Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
messages: Covalently attached to KCNB1; UBE2I increases cross-linking with KCNB1 and PIAS1 decreases cross-links with KCNB1 (By similarity). Interacts with SAE2, RANBP2, PIAS1 and PIAS2 (By similarity). Interacts with PRKN (PubMed:16955485). Covalently attached to a number of proteins such as IKFZ1, PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG (By similarity). Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52 (By similarity). Interacts with USP25 (via ts SIM domain); the interaction weakly sumoylates USP25 (By similarity). Interacts with SIMC1, CASP8AP2, RNF111 and SOBP (via SIM domains) (By similarity). Interacts with BHLHE40/DEC1 (By similarity). Interacts with RWDD3 (By similarity). Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3 (By similarity). Interacts with MTA1 (By similarity). Interacts with SENP2 (By similarity). Interacts with HINT1 (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Nucleus membrane
messages: Nucleus speckle
messages: PML body
messages: Polymeric SUMO1 chains undergo polyubiquitination by RNF4.
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3.

10116:Ugt2b7
gene id: 10116:Ugt2b7
uniprot id: Q62789
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol,catechol estrogens). Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II. Also metabolizes mycophenolate, an immunosuppressive agent.

10116:Tmprss13
gene id: 10116:Tmprss13
uniprot id: B2RYJ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Map4
gene id: 10116:Map4
uniprot id: A0A0G2JW88
uniprot id: A0A8L2QPR2
uniprot id: A6I3D0
uniprot id: Q5M7W5
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with SEPTIN2; this interaction impedes tubulin-binding. Interacts with TRAF3IP1 (By similarity). Interacts with KNSTRN (By similarity).
messages: Non-neuronal microtubule-associated protein. Promotes microtubule assembly (By similarity).
messages: Phosphorylation on Ser-761 negatively regulates MAP4 activity to promote microtubule assembly. Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly.
messages: cytoskeleton
messages: microtubule organizing center

10116:Bmt2
gene id: 10116:Bmt2
uniprot id: A6IE01
uniprot id: D3ZV22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

10116:Ube2e2
gene id: 10116:Ube2e2
uniprot id: A6K030
uniprot id: D3ZYE1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

10116:Mpp2
gene id: 10116:Mpp2
uniprot id: A0A8L2R7D6
uniprot id: D3ZAA9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MAGUK family.
messages: Can homomultimerise (PubMed:27756895). Interacts with CACNG2 (PubMed:27756895). Interacts (via the SH3-Guanylate kinase-like sub-module) with DLG4/PSD95 and DLGAP1/GKAP (PubMed:27756895). Interacts (via the PDZ domain) with CADM1 (via C-terminus) (PubMed:27756895). Interacts with KCNN2/SK2 (via N-terminal domain) (By similarity). Interacts with SRC (By similarity).
messages: Expressed in hippocampal neurons.
messages: Membrane
messages: Phosphorylated by SRC.
messages: Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (PubMed:27756895). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (By similarity).
messages: Postsynaptic density
messages: cytoskeleton
messages: dendrite

10116:Meox1
gene id: 10116:Meox1
uniprot id: A6HJF3
uniprot id: D4A532
names: Subcellular Location Annotation
messages: Nucleus

10116:Sypl1
gene id: 10116:Sypl1
uniprot id: A0A9K3Y7R4
uniprot id: Q66H18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

10116:Calcb
gene id: 10116:Calcb
uniprot id: P10093
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcitonin family.
messages: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
messages: Secreted

10116:Tbl3
gene id: 10116:Tbl3
uniprot id: Q5U2W5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: nucleolus

10116:Taar8c
gene id: 10116:Taar8c
uniprot id: A0A9K3Y7Q7
uniprot id: Q923Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

10116:Tmed11
gene id: 10116:Tmed11
uniprot id: D3ZE21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:Vcsa2
gene id: 10116:Vcsa2
uniprot id: P70676
names: Subcellular Location Annotation
messages: Secreted

10116:Tet3
gene id: 10116:Tet3
uniprot id: A6IAM2
uniprot id: D3ZQT7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

10116:Nr4a3
gene id: 10116:Nr4a3
uniprot id: A6KJG2
uniprot id: P51179
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR4 subfamily.
messages: By PDGF through a CREB-dependent transactivation of the NOR1 promoter.
messages: Expressed at high levels in cultured apoptotic neuronal cells and fetal brain, and at low level in adult brain.
messages: Interacts with SIX3 (via homeobox); differentially regulates the transcriptional activities of NR4A3. Interacts with NR3C1 (via nuclear receptor DNA-binding domain); the interactions represses transcription activity of NR4A3 on the POMC promoter Nur response element (NurRE) (PubMed:15591535). Interacts with TRIM28; the interactions potentiates NR4A3 activity on NurRE promoter (PubMed:19321449). Binds DNA as a monomer and homodimer (PubMed:10523643). Interacts with PARP1; activates PARP1 by improving acetylation of PARP1 and suppressing the interaction between PARP1 and SIRT1 (PubMed:25625556). Interacts with the constituents of DNA-PK heterotrimer PRKDC, XRCC6 and XRCC5; phosphorylates and prevents NR4A3 ubiquitinylation and degradation (By similarity). Interacts with NCOA2; potentiates the activity of the NR4A3. Interacts with NCOA1, NCOA3, MED1 and KAT2B. Interacts with EP300 and NCOA2; mediates the recruitment of MED1 in the coactivator complex (By similarity).
messages: Nucleus
messages: Phosphorylated by PRKDC.
messages: The AF-1 domain mediates transcription activation. The N-terminal region (1-292) directly interacts with the C-terminal LBD (380-627): the interaction is potentiated by AF-1-mediated recruitment of NCOA2.
messages: Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner (PubMed:7811288). Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (PubMed:10523643). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression (PubMed:16945922). In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (PubMed:24706823). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Also plays a role in inflammation; Upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similar…

10116:Ssr1
gene id: 10116:Ssr1
uniprot id: Q4V7D1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
messages: Membrane
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

10116:Cacng8
gene id: 10116:Cacng8
uniprot id: Q8VHW5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Cell membrane
messages: Interacts with CACNA1C. Identified in a complex with the L-type calcium channel subunits CACNA1C, CACNA2D1 and either CACNB1 or CACNB2 (By similarity). Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG7. Interacts with CNIH2 (By similarity).
messages: Palmitoylated (PubMed:23687301). Probably palmitoylated by ZDHHC3 and ZDHHC7 (PubMed:23687301).
messages: Postsynaptic density membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.

10116:Stra6l
gene id: 10116:Stra6l
uniprot id: A0A8I5ZVU0
uniprot id: A6IJA5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Gimap9
gene id: 10116:Gimap9
uniprot id: A0A8I5Y6X0
uniprot id: Q3ZAV4
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

10116:Aard
gene id: 10116:Aard
uniprot id: Q91ZF7
names: Developmental Stage
messages: Up-regulated during postnatal lung development.

10116:Psmd5
gene id: 10116:Psmd5
uniprot id: A6JUD4
uniprot id: B2RYP1
uniprot id: G3V8G2
names: Similarity
messages: Belongs to the proteasome subunit S5B/HSM3 family.

10116:Nox4
gene id: 10116:Nox4
uniprot id: A6I5Y4
uniprot id: Q924V1
names: Activity Regulation
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by insulin. Inhibited by diphenylene iodonium. Inhibited by plumbagin. Activated by phorbol 12-myristate 13-acetate (PMA) (By similarity).
messages: Cell membrane
messages: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB.
messages: Endoplasmic reticulum membrane
messages: Expressed in vascular smooth muscle.
messages: Interacts with TLR4 (By similarity). Interacts with, relocalizes and stabilizes CYBA/p22phox. Interacts with protein disulfide isomerase. Interacts with PPP1R15A (By similarity).
messages: Membrane
messages: N-glycosylation is required for the function.
messages: Up-regulated in diabetic kidney (at protein level).
messages: focal adhesion

10116:Dnaja2
gene id: 10116:Dnaja2
uniprot id: F7F428
uniprot id: Q5M9H7
names: Subcellular Location Annotation
messages: Membrane

10116:Paf1
gene id: 10116:Paf1
uniprot id: A6J9I9
uniprot id: Q4V886
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAF1 family.
messages: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors (By similarity).
messages: Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and SKIC8 (By similarity). The PAF1 complex interacts with PHF5A (By similarity). Interacts with POLR2A, TCEA1, SKIC3, KMT2A/MLL1, SUPT5H, RNF20 and RNF40. Interacts with UBE2E1 (By similarity).
messages: Nucleus

10116:Slc35b4
gene id: 10116:Slc35b4
uniprot id: A6IEL0
uniprot id: D3ZAN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

10116:Gphn
gene id: 10116:Gphn
uniprot id: Q03555
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in tissues including spinal cord, brain, liver, kidney and lung.
messages: Has also a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: Homotrimer, homodimer and homooligomer (PubMed:11325967, PubMed:25137389, PubMed:25531214). Interacts with SRGAP2 (via SH3 domain) (By similarity). Interacts with GLRB (PubMed:15201864, PubMed:16511563, PubMed:25137389, PubMed:25531214). Interacts with GABARAP (PubMed:10900017). Interacts with GABRA3 (PubMed:25531214). GABRA3 and GLRB occupy overlapping binding sites (PubMed:25531214). Interacts with ARHGAP32; IQSEC3, INSYN1 and INSYN2A (By similarity).
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.
messages: Inhibited by copper and tungsten.
messages: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (PubMed:8264797). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (By similarity).
messages: Palmitoylated. Palmitoylation is stimulated by GABA type A receptors activity. Palmitoylation by ZDHHC12 regulates clustering at synapses.
messages: Phosphorylated.
messages: Postsynaptic cell membrane
messages: Postsynaptic density
messages: cytoskeleton
messages: cytosol
messages: dendrite

10116:Or6n1
gene id: 10116:Or6n1
uniprot id: D4A926
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Rsad2
gene id: 10116:Rsad2
uniprot id: O70600
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: 'Lys-6'-linked polyubiquitination at Lys-205 leads to RSAD2 protein degradation.
messages: Acetylated by HAT1. HAT1-mediated acetylation of Lys-196 in turn recruits UBE4A that stimulates RSAD2 polyubiquitination leading to proteasomal degradation.
messages: Belongs to the radical SAM superfamily. RSAD2 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: By interferon type I, type II and LPS. Interferon alpha induction is rapid and transient, peaks 4-6 hours after stimulation and returns to basal levels 24 hours after stimulation. Interferon gamma elicits a more prolonged response where expression remains elevated 48 hours after stimulation. Induced by infection with Vesicular stomatitis virus and pseudorabies virus, presumably through type I interferon pathway.
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Homodimer. Interacts with IRAK1 and TRAF6. Interacts with FPPS. Interacts with HADHB. Interacts (via C-terminus) with VAPA/VAP33 (via C-terminus).
messages: IRAK1 and TRAF6 synergistically activate RSAD2 increasing its activity with CTP as substrate about 10-fold.
messages: In neonatal rat tibia, specifically localized in cells of the periosteum, in osteoblasts lining endosteal and peristeal bone surfaces, to articular surfaces of cartilage and in perichondral cells but not in chondrocytes (at protein level). Expressed predominantly in bone marrow and spleen.
messages: Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses. Promotes also TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins.
messages: Lipid droplet
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane
messages: Not detected in undifferentiated primary osteoblasts. Expression increases during differentiation and declines to much reduced levels in mature osteoblasts.
messages: The N-terminal region (1-41) is necessary for its localization to the endoplasmic reticulum membrane and lipid droplet.

10116:Rnase1l1
gene id: 10116:Rnase1l1
uniprot id: F1M5W9
uniprot id: Q8VD88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pancreatic ribonuclease family.
messages: Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA (By similarity).
messages: Monomer.
messages: Secreted

10116:Sdc1
gene id: 10116:Sdc1
uniprot id: A6HAM5
uniprot id: P26260
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (By similarity). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity).
messages: Cell surface proteoglycan.
messages: Interacts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain) (By similarity). Interacts with MDK (PubMed:9089390).
messages: Membrane
messages: Secreted
messages: Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3 (By similarity).
messages: extracellular exosome

10116:Crygn
gene id: 10116:Crygn
uniprot id: D3ZEG1
names: Domain
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens. Also plays an important role for integrity and function of auditory nuclei.
messages: Detected in the auditory hindbrain where it is highly expressed in the medial nucleus of the trapezoid body, but also present in other nuclei of the superior olivary complex.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Monomer.

10116:Lurap1
gene id: 10116:Lurap1
uniprot id: D4A8G3
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an activator of the canonical NF-kappa-B pathway and drive the production of pro-inflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (By similarity). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella.
messages: Cytoplasm
messages: Forms a tripartite complex with CDC42BPA/CDC42BPB and MYO18A acting as an adapter connecting both. Its binding to CDC42BPA/CDC42BPB results in their activation by abolition of their negative autoregulation (PubMed:18854160). Interacts with CDC42BPA and CDC42BPB (PubMed:25107909).
messages: Phosphorylated.

10116:Snu13
gene id: 10116:Snu13
uniprot id: A6HT44
uniprot id: P55770
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: Identified in the spliceosome B complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Interacts with RAD17 and PRPF31. The complex formed by SNU13 and PRPF31 binds U4 snRNA. The complex formed by SNU13 and PRPF31 binds also U4atac snRNA, a characteristic component of specific, less abundant spliceosomal complexes. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Nucleus
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.
messages: nucleolus

10116:Cpa1
gene id: 10116:Cpa1
uniprot id: A6IEH1
uniprot id: P00731
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (By similarity). Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond (By similarity).
messages: Monomer. May form a complex with proelastase 2.
messages: Secreted

10116:Rplp1
gene id: 10116:Rplp1
uniprot id: A6J567
uniprot id: P19944
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Heterodimer with RPLP2 at the lateral ribosomal stalk of the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.
messages: Ubiquitinated at Lys-92 and Lys-93 by RNF14 and RNF25 in response to ribosome collisions (ribosome stalling).

10116:Fh
gene id: 10116:Fh
uniprot id: P14408
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ). In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 'Lys-36' (H3K36me2) (By similarity).
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.
messages: Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (By similarity). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable).
messages: Chromosome
messages: Homotetramer. Interacts with H2AZ1.
messages: Mitochondrion
messages: Nucleus
messages: Phosphorylation at Thr-233 by PRKDC in response to DNA damage promotes translocation to the nucleus and recruitment to DNA double-strand breaks (DSBs).
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.
messages: cytosol

10116:Tbl1x
gene id: 10116:Tbl1x
uniprot id: A0A0G2JY80
uniprot id: A6IPS7
names: Similarity
messages: Belongs to the WD repeat EBI family.

10116:Agbl1
gene id: 10116:Agbl1
uniprot id: A0A1B0GWW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

10116:Mx2
gene id: 10116:Mx2
uniprot id: A0A0G2KAR4
uniprot id: A6IQG6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

10116:Mocs2
gene id: 10116:Mocs2
uniprot id: A6I5T0
uniprot id: Q6AY59
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

10116:Foxj3
gene id: 10116:Foxj3
uniprot id: A0A0G2JWM4
uniprot id: A6JZP5
names: Subcellular Location Annotation
messages: Nucleus

10116:Pik3c3
gene id: 10116:Pik3c3
uniprot id: A0A8L2QUD7
uniprot id: A6J2N0
uniprot id: O88763
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PI3/PI4-kinase family.
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Involved in the transport of lysosomal enzyme precursors to lysosomes (PubMed:11171063). Required for transport from early to late endosomes (PubMed:11171063).
messages: Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex the core of which is composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 associating with additional regulatory/auxilliary subunits to form alternative complex forms. Alternative complex forms containing a forth regulatory subunit in a mutually exclusive manner are: the PI3K complex I (PI3KC3-C1) containing ATG14, and the PI3K complex II (PI3KC3-C2) containing UVRAG. PI3KC3-C1 displays a V-shaped architecture with PIK3R4 serving as a bridge between PIK3C3 and the ATG14:BECN1 subcomplex. Both, PI3KC3-C1 and PI3KC3-C2, can associate with further regulatory subunits such as RUBCN, SH3GLB1/Bif-1 and AMBRA1. PI3KC3-C1 probably associates with PIK3CB. Interacts with RAB7A in the presence of PIK3R4. Interacts with AMBRA1. Interacts with BECN1P1/BECN2. Interacts with SLAMF1. May interact with DYN2. May be a component of a complex composed of RAB5A (in GDP-bound form), DYN2 and PIK3C3 (By similarity). Interacts with NCKAP1L (By similarity). Interacts with ATG14; this interaction is increased in the absence of TMEM39A (By similarity). Interacts with STEEP1; the interaction is STING1-dependent and required for trafficking of STING1 from the endoplasmic reticulum (By similarity). Interacts with YWHAG (By similarity).
messages: Late endosome
messages: Midbody
messages: Ubiquitinated via 'Lys-29'- and 'Lys-48'-linked ubiquitination by UBE3C, promoting its degradation. Deubiquitination by ZRANB1/TRABID promotes its stabilization, leading to autophagosome maturation.
messages: autophagosome

10116:Bhlhb9
gene id: 10116:Bhlhb9
uniprot id: A6KT33
uniprot id: Q71HP2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPRASP family.
messages: Cytoplasm
messages: Despite its name, no basic helix-loop-helix (bHLH) domain is detected by any prediction tool.
messages: Homodimer.
messages: Nucleus
messages: Survival and differentiation promoting protein that plays a role in the regulation of neurosynaptogenesis. Induces phosphatase PP2A activity which results in APP dephosphorylation and inhibits BACE1-mediated processing of APP.

10116:Acyp2
gene id: 10116:Acyp2
uniprot id: A0A8I6AGK8
uniprot id: A6JQC8
uniprot id: D4A1G1
names: Similarity
messages: Belongs to the acylphosphatase family.

10116:Rps25
gene id: 10116:Rps25
uniprot id: A6J3Z0
uniprot id: P62853
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS25 family.
messages: Component of the small ribosomal subunit.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

10116:Olr1107
gene id: 10116:Olr1107
uniprot id: F7F8N8
uniprot id: Q5USB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Dhrs7
gene id: 10116:Dhrs7
uniprot id: D4A0T8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

10116:Cblb
gene id: 10116:Cblb
uniprot id: A0A0G2K8K2
uniprot id: Q8K4S7
names: Disease Annotation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Auto-ubiquitinated upon EGF-mediated cell activation or upon T-cell costimulation by CD28; which promotes proteasomal degradation.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity).
messages: Interacts with SH3 domain-containing proteins LCK, CRK and SORBS1. Interacts with LCP2 and ZAP70. Interacts with CBL. Interacts with SH3 domain-containing proteins VAV1, FYN, FGR, PLCG1, GRB2, CRKL, PIK3R1 and SH3KBP1/CIN85. Identified in heterotrimeric complexes with SH3KBP1/CIN85, CD2AP and ARHGEF7, where one CBLB peptide binds two copies of the other protein. Interacts with poly-ubiquitinated proteins. Dimerization is required for the binding of poly-ubiquitin, but not for the binding of mono-ubiquitin. Interacts with EGFR (phosphorylated). Interacts with IFT20.
messages: Lack of Cblb expression is the cause of the Komeda diabetes-prone (KDP) phenotype, characterized by autoimmune destruction of pancreatic beta cells and rapid onset of overt diabetes with no sex difference and no significant T-cell lymphopenia. The KPD rat is a spontaneous animal model for human type 1 diabetes mellitus.
messages: Phosphorylated on tyrosine and serine residues upon TCR or BCR activation, and upon various types of cell stimulation.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.
messages: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
messages: The UBA domain interacts with poly-ubiquitinated proteins.
messages: This protein has one functional calcium-binding site.

10116:Sftpa1
gene id: 10116:Sftpa1
uniprot id: P08427
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SFTPA family.
messages: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.
messages: Oligomeric complex of 6 set of homotrimers.
messages: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).
messages: Secreted
messages: extracellular matrix
messages: surface film

10116:Armc5
gene id: 10116:Armc5
uniprot id: Q5PQP9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in fetal development, T-cell function and adrenal gland growth homeostasis (By similarity). Negatively regulates adrenal cells survival. Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (By similarity).

10116:Pcdh8
gene id: 10116:Pcdh8
uniprot id: D3ZE55
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At 17 dpc, expressed in the auditory circuit, most prominently in the inferior colliculus, and later in the medial geniculate and the auditory cortex at P0. At P0, also expressed in targets of retinal projections, such as the superior colliculus, the suprachiasmatic nucleus, and the ventrolateral geniculate nucleus. At the same stage, detected in selected structures of the limbic circuit, including the anterior limbic thalamic nuclei, the hippocampus, amygdala and habenula.
messages: Calcium-dependent cell-adhesion protein. May play a role in activity-induced synaptic reorganization underlying long term memory. Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis.
messages: Cell membrane
messages: Enriched in brain relative to peripheral tissues, with low expression in the testis. Expressed in hippocampal neurons (at protein level).
messages: May be the only physiologically relevant isoform.
messages: Postsynaptic cell membrane
messages: Presynaptic cell membrane
messages: Rapidly and transiently induced by maximal electroconvulsive seizure in the hippocampal granule cells, and modestly induced in the pyramidal cells. Also induced by cAMP.
messages: The N-terminal extracellular domain forms homophilic interactions; these interactions activate p38 MAPK via TAOK2 and trigger endocytosis. Interacts with CDH2; this interaction may lead to CDH2 cointernalization. Interacts with CDH11. Interacts with TAOK2.
messages: dendrite

10116:Rad51d
gene id: 10116:Rad51d
uniprot id: A0A8I6AMP7
uniprot id: A0A8I6GKB7
uniprot id: A6HHE9
uniprot id: A6HHF0
uniprot id: F7ET37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus

10116:Rpain
gene id: 10116:Rpain
uniprot id: Q4G2Y1
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with the RPA1 subunit of RPA complex.
messages: Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Sumoylation mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism (By similarity).
messages: Nucleus
messages: Sumoylated; required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues (By similarity).

10116:Ccni
gene id: 10116:Ccni
uniprot id: A6KK51
uniprot id: D4A5E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family.
messages: Nucleus

10116:Map2k4
gene id: 10116:Map2k4
uniprot id: Q4KSH6
names: Similarity
messages: Belongs to the protein kinase superfamily.

10116:Nampt
gene id: 10116:Nampt
uniprot id: A6HB68
uniprot id: Q80Z29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.
messages: Cytoplasm
messages: Expressed in various tissues. At the highest level in liver and at the second highest in heart. The amount is higher in heart than in lung.
messages: Homodimer.
messages: Nucleus
messages: Secreted

10116:Nfx1
gene id: 10116:Nfx1
uniprot id: A6IIT2
uniprot id: D4AE50
uniprot id: Q4V7B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

10116:Fam76a
gene id: 10116:Fam76a
uniprot id: A6ISV3
uniprot id: D3ZEU8
names: Similarity
messages: Belongs to the FAM76 family.

10116:Kcnj1
gene id: 10116:Kcnj1
uniprot id: A0A0G2JYW2
uniprot id: A0A0G2K298
uniprot id: A0A8I6AW52
uniprot id: A6JYH9
uniprot id: A6JYI0
uniprot id: A6JYI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

10116:Ccr8
gene id: 10116:Ccr8
uniprot id: D4ADE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

10116:LOC100911728
gene id: 10116:LOC100911728
uniprot id: A0A8I6A2I7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

10116:Aox2
gene id: 10116:Aox2
uniprot id: Q5QE78
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: AOX genes evolved from a xanthine oxidoreductase ancestral precursor via a series of gene duplication and suppression/deletion events. Different animal species contain a different complement of AOX genes encoding an equivalent number of AOX isoenzymes. In mammals, the two extremes are represented by certain rodents such as mice and rats, which are endowed with 4 AOX genes, and by humans, whose genome is characterized by a single active gene (PubMed:23263164).
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as phthalazine, as well as aldehydes, such as benzaldehyde and retinal.

10116:Proz
gene id: 10116:Proz
uniprot id: B1H253
uniprot id: G3V8K8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Mpv17l
gene id: 10116:Mpv17l
uniprot id: A6K4F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

10116:Hoxa3
gene id: 10116:Hoxa3
uniprot id: A6K0Q4
uniprot id: D3ZM81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

10116:Irak1bp1
gene id: 10116:Irak1bp1
uniprot id: D3ZBV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

10116:Vps26b
gene id: 10116:Vps26b
uniprot id: B1WBS4
uniprot id: M0R4K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

10116:Plin1
gene id: 10116:Plin1
uniprot id: A6JC64
uniprot id: F1LSF5
names: Similarity
messages: Belongs to the perilipin family.

10116:Or1e25
gene id: 10116:Or1e25
uniprot id: A0A8I5ZSD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ndufaf3
gene id: 10116:Ndufaf3
uniprot id: A6I367
uniprot id: O08776
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Expressed in testis.
messages: Interacts with NDUFAF4, NDUFS2 and NDUFS3.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

10116:Mrgpre
gene id: 10116:Mrgpre
uniprot id: Q7TN40
uniprot id: W8W3M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
messages: Cell membrane
messages: Membrane
messages: Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

10116:Rps10l1
gene id: 10116:Rps10l1
uniprot id: A6JJM8
uniprot id: P63326
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS10 family.
messages: Component of the 40S ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Component of the small ribosomal subunit. The methylated form interacts with NPM1.
messages: Cytoplasm
messages: Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation.
messages: Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide. Deubiquitinated by OTUD3 and USP21, antagonizing ZNF598 activity. Deubiquitinated by OTUD1, antagonizing ZNF598 activity and stimulating formation of polysomes: deubiquitination by OTUD1 promotes stability and translation of a subset mRNAs with a high abundance of rare codons can limit the translation rate. Deubiquitinated by USP10.
messages: nucleolus

10116:Or2h1
gene id: 10116:Or2h1
uniprot id: Q6MFX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Lbx1
gene id: 10116:Lbx1
uniprot id: A6JHI0
uniprot id: Q1XID0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with SKOR1 which acts as a transcriptional corepressor.
messages: Nucleus
messages: Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.

10116:Ccdc25
gene id: 10116:Ccdc25
uniprot id: A6K6K7
uniprot id: D4AAU6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

10116:Tbx15
gene id: 10116:Tbx15
uniprot id: A6K3E9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

10116:Nfe2
gene id: 10116:Nfe2
uniprot id: Q6AYT2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. CNC subfamily.
messages: Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron (By similarity).
messages: Cytoplasm
messages: Homodimer; can bind DNA as a homodimer (By similarity). Erythroid transcription activator nuclear factor erythroid-derived 2 (NF-E2), composed of a heterodimer of NFE2 and MAFK, possesses transactivation activity on beta-globin. Also forms high affinity heterodimer with MAFG; the interaction promotes erythropoiesis. Interacts (via the PXY motif 1) with ITCH (via the WW 1 domain); the interaction promotes 'Lys63'-linked ubiquitination of NFE2, translocates it to the cytoplasm and inhibits its transactivation activity. Interacts with KMT2D/MLL2; the interaction promotes transactivation of the beta-globin locus. Interacts with MAPK8 (phosphorylated form); the interaction leads to phosphorylation of NFE2 in undifferentiated cells (By similarity).
messages: PML body
messages: Phosphorylated on serine residues. In undifferentiated erythrocytes, phosphorylated by MAPK8 which then leads to ubiquitination and protein degradation.
messages: Sumoylated. Sumoylation is required for translocation to nuclear bodies PODs, anchoring to the gene loci, and transactivation of the beta-globin gene.
messages: The PXY motifs are required for binding WW domains. PXY1 is required to promote transactivation of beta-globin and for hyperacetylation of histone H3, but not for binding to the HS2 promoter site.
messages: Ubiquitinated mainly by 'Lys63'-linked ubiquitin. Polyubiquitination with 'Lys63'-linked ubiquitin by ITCH retains NFE2 in the cytoplasm preventing its transactivation activity. In undifferentiated erythrocyte, ubiquitinated after MAPK8-mediatd phosphorylation leading to protein degradation.

10116:Arl4d
gene id: 10116:Arl4d
uniprot id: A0A8I5ZPR4
uniprot id: B2RZ70
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

10116:Hus1
gene id: 10116:Hus1
uniprot id: A6KJ83
uniprot id: D3ZNA8
names: Similarity
messages: Belongs to the HUS1 family.

10116:Cpne8
gene id: 10116:Cpne8
uniprot id: A0A8I5ZKW9
uniprot id: A6K7P9
uniprot id: B5DEX3
uniprot id: F7EN58
names: Similarity
messages: Belongs to the copine family.

10116:Rsrc1
gene id: 10116:Rsrc1
uniprot id: Q5PPJ2
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts (via Arg/Ser-rich domain) with LUC7L3, RBM39 and RSF1.
messages: Nucleus
messages: Nucleus speckle
messages: Phosphorylated.
messages: Plays a role in pre-mRNA splicing. Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing (By similarity).

10116:Hspb8
gene id: 10116:Hspb8
uniprot id: A6J1Q6
uniprot id: Q9EPX0
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: By heat shock.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Monomer. Interacts with HSPB1 (By similarity). Interacts with DNAJB6 (By similarity). Interacts with BAG3 (By similarity).
messages: Nucleus
messages: Phosphorylated.

10116:Atp5f1e
gene id: 10116:Atp5f1e
uniprot id: A6KL35
uniprot id: P29418
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
messages: Mitochondrion
messages: Mitochondrion inner membrane

10116:Or4c120
gene id: 10116:Or4c120
uniprot id: A6HN31
uniprot id: D3ZCA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:B4galt1
gene id: 10116:B4galt1
uniprot id: A6IIS4
uniprot id: G3V722
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

10116:Kars1
gene id: 10116:Kars1
uniprot id: Q5XIM7
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:6315704). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (By similarity). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:3988754, PubMed:2995387, PubMed:19524539).
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer (By similarity). Part of the multisynthetase complex (MSC), a multisubunit complex that groups tRNA ligases for Arg (RARS), Asp (DARS), Gln (QARS), Ile (IARS), Leu (LARS), Lys (KARS), Met (MARS) the bifunctional ligase for Glu and Pro (EPRS) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:3988754, PubMed:2995387, PubMed:19524539). Interacts with AIMP2 (via N-terminus) and MITF (PubMed:23159739). Interacts with TARSL2 (By similarity).
messages: It is likely that the same gene provides both this cytoplasmic isoform and an additional mitochondrial isoform.
messages: Nucleus
messages: Phosphorylated on a serine residue after mast cell stimulation with immunoglobulin E (IgE).
messages: Secreted
messages: The N-terminal domain (1-65) is a functional tRNA-binding domain and is involved in the interaction with DARS, but has a repulsive role in the binding to EEF1A1. A central domain (208-259) is involved in homodimerization. The C-terminal domain (452-597) is not required for interaction with AIMP2 (By similarity).
messages: cytosol

10116:Fcho1
gene id: 10116:Fcho1
uniprot id: D3ZIM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FCHO family.
messages: clathrin-coated pit

10116:Gba2
gene id: 10116:Gba2
uniprot id: A6IJ37
uniprot id: D4A6U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the non-lysosomal glucosylceramidase family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.

10116:Fnip2
gene id: 10116:Fnip2
uniprot id: A0A0G2JUW9
uniprot id: A0A8I6AG09
uniprot id: D3Z8I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

10116:Suclg1
gene id: 10116:Suclg1
uniprot id: P13086
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Chimeric cDNA.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

10116:Nudt3
gene id: 10116:Nudt3
uniprot id: A6JJM7
uniprot id: Q566C7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:9822604). InsP6 (inositol hexakisphosphate) is not a substrate (By similarity). Acts as a negative regulator of the ERK1/2 pathway (By similarity). Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates (By similarity). The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A (By similarity). Also able to hydrolyze 5- phosphoribose 1-diphosphate (By similarity). Acts as a decapping enzyme that can hydrolyze both monomethylated and unmethylated capped RNAs (By similarity). Hydrolyzes monomethylated capped RNA after both the alpha- and beta-phosphates generating m7GMP + ppRNA and m7GDP + pRNA (By similarity). Modulates the stability of a subset of mRNAs implicated in cell motility (By similarity). Divalent cations zinc, magnesium and manganese determine its substrate specificity (By similarity). Exhibits endopolyphosphatase activity in the presence of zinc ions (PubMed:34788624). Exhibits diphosphoinositol polyphosphate phosphohydrolase in the presence of magnesium ions and diadenosine hexaphosphate hydrolase activity in the presence of manganese ions (By similarity). Plays an important role in limiting DNA damage and maintaining cell survival upon oxidative stress via its endopolyphosphatase activity (By similarity).
messages: Cytoplasm
messages: Diphosphoinositol polyphosphate phosphohydrolase is inhibited by fluoride and InsP6.
messages: Monomer.
messages: Nucleus

10116:Elob
gene id: 10116:Elob
uniprot id: P62870
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. This includes the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. As part of a multisubunit ubiquitin ligase complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A (By similarity). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity).
messages: Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit (By similarity). The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex (By similarity). Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either ASB2, KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B, FEM1C, LRR1, SOCS1, SOCS5, ELOA, VHL or WSB1. Interacts with VHL. Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, ELOB and CUL2. Interacts with SPSB1. Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component. May also interact with DCUN1D1, DCUN1D2, DCUN1D3 and DCUN1D5 (By similarity). As part of the Elongin BC E3 ubiquitin ligase complex; interacts with NRBP1 (By similarity). Component of the ECS(PCMTD1) complex with the substrate recognition subunit PCMTD1. Interacts with PCMTD1 (via the BC-box); the interaction is direct and stabilizes PCMTD1 (By similarity).
messages: Nucleus
messages: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity).

10116:Klhdc8b
gene id: 10116:Klhdc8b
uniprot id: Q5XIA9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells.
messages: Midbody

10116:Pigw
gene id: 10116:Pigw
uniprot id: A6HHM4
uniprot id: D4AA75
uniprot id: Q7TSN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.
messages: Required for the transport of GPI-anchored proteins to the plasma membrane (By similarity). Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (PubMed:14517336).

10116:Fbxw5
gene id: 10116:Fbxw5
uniprot id: Q4KLI9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBXW5 family.
messages: Cytoplasm
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXW5) composed of CUL1, SKP1, RBX1 and FBXW5. Component of the DCX(FBXW5) E3 ubiquitin ligase complex, at least composed of (CUL4A or CUL4B), DDB1, FBXW5 and RBX1. Interacts with CDC20, EPS8, TSC1, TSC2 and SASS6.Interacts with TNFAIP8L1; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.
messages: Phosphorylated at Ser-151 by PLK4 during the G1/S transition, leading to inhibit its ability to ubiquitinate SASS6.
messages: Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway (By similarity).
messages: The D-box (destruction box) mediate the interaction with APC proteins, and acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
messages: The F-box domain mediates interaction with components of SCF (SKP1-CUL1-F-box protein) complexes, while WD repeats mediate interaction with components of DCX (DDB1-CUL4-X-box) complexes.
messages: Ubiquitinated and degraded by the APC/C complex during mitosis and G1 phase.

10116:Elovl3
gene id: 10116:Elovl3
uniprot id: A6JHL1
uniprot id: D3ZPX9
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL3 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.

10116:Ppox
gene id: 10116:Ppox
uniprot id: A6JFW5
uniprot id: D3ZVN7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavin monoamine oxidase family.
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

10116:Rps8
gene id: 10116:Rps8
uniprot id: B2RYR8
uniprot id: P62243
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Component of the small ribosomal subunit. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: Cytoplasm
messages: Membrane
messages: nucleolus

10116:Tsku
gene id: 10116:Tsku
uniprot id: Q6QMY6
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways. Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye. Plays a role in regulating the hair cycle by controlling TGFB1 signaling. Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth. Essential for terminal differentiation of hippocampal neural stem cells. Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size. Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells. Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence. Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver. In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure. In another study, shown not to affect brown fat thermogenic capacity, body weight gain or glucose homeostasis.
messages: Early induced by insulin independently of glucose and by 17-beta-estradiol in liver.
messages: Expressed at high levels in the liver, small intestine and placenta. Not or barely detectable in other tissues, including whole pancreas, adipose tissues, skeletal muscle, kidney, spleen, brain, lung and testis.
messages: Interacts with FZD4 (via FZ domain); competes with WNT2B for binding to FZD4, inhibiting Wnt signaling and repressing peripheral eye development. Interacts with TGFB1; the interaction contributes to regulation of the hair cycle. Interacts with netrin. Interacts with CCN2.
messages: Secreted
messages: This factor is named 'Tsukushi' because its expression pattern in chick embryos is similar to the shape of the Japanese horsetail plant, tsukushi.

10116:Rnase2
gene id: 10116:Rnase2
uniprot id: Q5WN11
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

10116:Klhl24
gene id: 10116:Klhl24
uniprot id: Q56A24
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autoubiquitinated. Autoubiquitination leads to proteasomal degradation and is necessary to control KLHL24 levels.
messages: Cytoplasm
messages: Expressed in the brain.
messages: Forms homodimers. Interacts with GRIK2 (PubMed:17254796). Component of the BCR(KLHL24) E3 ubiquitin ligase complex, composed of CUL3, RBX1 and KLHL24. Interacts with CUL3. Interacts with KRT14 (By similarity).
messages: In 3-week postnatal brain, prominent in the cortex and in the hippocampus. In the hippocampal formation, detectable in the CA1-CA3 pyramidal cells and in the granule cell layer of the dentate gyrus. In the cerebral cortex, expressed in all layers (I-VI) (at protein level). In 10 week old animals, tends to segregate in CA3 regions.
messages: Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (By similarity). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (By similarity). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (PubMed:17254796). Has a crucial role in cardiac development and function (By similarity).
messages: Perikaryon
messages: adherens junction
messages: axon
messages: desmosome

10116:Fas
gene id: 10116:Fas
uniprot id: A6I127
uniprot id: F1LWQ2
uniprot id: Q63199
names: Caution
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2. Interacts with BABAM2 and FEM1B. Interacts with FADD (By similarity). Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (PubMed:15383280). Interacts with CALM (By similarity). In the absence of stimulation, interacts with BIRC2, DDX3X and GSK3B. The interaction with BIRC2 and DDX3X is further enhanced upon receptor stimulation and accompanied by DDX3X and BIRC2 cleavage (By similarity).
messages: Cell membrane
messages: Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft
messages: Palmitoylated. Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane.
messages: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).

10116:Or5an10
gene id: 10116:Or5an10
uniprot id: A0A8I6A045
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tpr
gene id: 10116:Tpr
uniprot id: A0A8I6ALQ6
uniprot id: A0A8L2UNA6
names: Similarity
messages: Belongs to the TPR family.

10116:Sugt1
gene id: 10116:Sugt1
uniprot id: A6HU03
uniprot id: B0BN85
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGT1 family.
messages: Cytoplasm
messages: May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
messages: Nucleus
messages: Phosphorylated at Ser-252 and Ser-302, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex.
messages: Probably associates with SCF (SKP1-CUL1-F-box protein) complex through interaction with SKP1. Interacts with S100A6. Interacts with HSP90 (By similarity).
messages: The CS domain mediates interaction with HSP90.

10116:Atxn2l
gene id: 10116:Atxn2l
uniprot id: A0A8I6APD6
uniprot id: A0A8J8XYP8
uniprot id: B3DMA1
names: Similarity
messages: Belongs to the ataxin-2 family.

10116:Cttnbp2
gene id: 10116:Cttnbp2
uniprot id: Q2IBD4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.
messages: Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance.
messages: cell cortex
messages: dendritic spine

10116:Coq7
gene id: 10116:Coq7
uniprot id: A6I8H3
uniprot id: A6I8H4
uniprot id: G3V879
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

10116:Fbxo11
gene id: 10116:Fbxo11
uniprot id: Q7TSL3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Component of the SCF(FBXO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with p53/TP53, BCL6 and DTL (when not phosphorylated). Interacts with PRDM1.
messages: Nucleus
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53LOG.

10116:Hoxc12
gene id: 10116:Hoxc12
uniprot id: A6KCY2
uniprot id: D4ACL4
names: Subcellular Location Annotation
messages: Nucleus

10116:Clec2l
gene id: 10116:Clec2l
uniprot id: Q0ZCA7
names: Subcellular Location Annotation
messages: Membrane

10116:Slc5a3
gene id: 10116:Slc5a3
uniprot id: A0A8I6GM79
uniprot id: A6JLI6
uniprot id: Q80WA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

10116:Zhx2
gene id: 10116:Zhx2
uniprot id: Q80VX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells. In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex.
messages: Belongs to the ZHX family.
messages: Homodimer (via homeobox domain 1). Heterodimer with ZHX1 (via homeobox domain 1). Heterodimer with ZHX3 (via homeobox domain 1). Heterodimerization with ZHX1 is not necessary for repressor activity. Interacts (via homeobox domain) with NFYA (via N-terminus). Interacts with EFNB1 intracellular domain peptide; the interaction enhances ZHX2 transcriptional repression activity.
messages: Nucleus

10116:Ddt
gene id: 10116:Ddt
uniprot id: A0A0F7RQJ6
uniprot id: P80254
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MIF family.
messages: Cytoplasm
messages: Homotrimer.
messages: In all organs tested, highest levels in liver.
messages: Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).

10116:Csdc2
gene id: 10116:Csdc2
uniprot id: Q63430
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At 18 dpc, expressed in the cerebellum.
messages: Brain-specific. Expression restricted to the pyramidal neurons of the cerebral cortex and in the Purkinje cells of the cerebellum.
messages: Cytoplasm
messages: Nucleus
messages: RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain.

10116:Ccng1
gene id: 10116:Ccng1
uniprot id: A6HDL0
uniprot id: P39950
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family.
messages: Belongs to the cyclin family. Cyclin G subfamily.
messages: By doxorubicin (DOX).
messages: Induced within 3 hours after growth stimulation, remains elevated with no apparent cell cycle dependency.
messages: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.
messages: Nucleus

10116:Aoc1
gene id: 10116:Aoc1
uniprot id: F6WEU8
uniprot id: Q498N2
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

10116:Chordc1
gene id: 10116:Chordc1
uniprot id: D4A4T9
names: Function
names: Subunit
messages: Interacts with HSP90AA1, HSP90AB1, PPP5C, ROCK1 and ROCK2.
messages: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (By similarity). Involved in stress response. Prevents tumorigenesis (By similarity).

10116:Unk
gene id: 10116:Unk
uniprot id: D3ZV40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm

10116:Akap14
gene id: 10116:Akap14
uniprot id: O35817
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds to type II regulatory subunits (RII).
messages: Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
messages: Cytoplasm
messages: Expressed at detectable levels 30 days after birth and increased greatly during the next 10 days.
messages: Testis specific.

10116:Atg12
gene id: 10116:Atg12
uniprot id: A6IWW9
uniprot id: Q2TBJ5
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300.
messages: Activated in retinal ganglion cells (RGCs) following optic nerve transection (PubMed:18521932). Induced under starvation conditions, through the action of the Foxo1 and Foxo3 transcription factors (PubMed:19696026, PubMed:24187137).
messages: Belongs to the ATG12 family.
messages: Cytoplasm
messages: Forms a conjugate with ATG5.
messages: Forms a conjugate with ATG5. The ATG12-ATG5 conjugate forms a complex with several units of ATG16L1. Forms an 800-kDa complex composed of ATG12-ATG5 and ATG16L2 (By similarity). Interacts with ATG3, ATG7 and ATG10. ATG12-ATG5 also interacts with MAVS, MGA, RARRES3 and TECPR1 (By similarity). Interacts with SH3BGRL (By similarity).
messages: Preautophagosomal structure membrane
messages: Shares weak sequence similarity with ubiquitin family, but contains an 'ubiquitin superfold' and the C-terminal Gly is required for isopeptide linkage.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.
messages: Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus (By similarity).

10116:Olr220
gene id: 10116:Olr220
uniprot id: A6I7Q3
uniprot id: D3ZZ28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Myo5b
gene id: 10116:Myo5b
uniprot id: A0A8I5ZST3
uniprot id: P70569
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with RAB11FIP2 (By similarity). Interacts with RAB11A and RAB8A (By similarity). Found in a complex with CFTR and RAB11A (By similarity). Interacts with NPC1L1 (By similarity). Interacts with LIMA1 (By similarity).
messages: Cytoplasm
messages: May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes.

10116:Hcrtr2
gene id: 10116:Hcrtr2
uniprot id: A6I1F5
uniprot id: P56719
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in the brain in the cerebral cortex, septal nuclei, hippocampus, medial thalamic groups, dorsal and median raphe nuclei, and many hypothalamic nuclei including the tuberomammillary nucleus, dorsomedial hypothalamus, paraventricular hypothalamic nucleus, and ventral premammillary nucleus. Not detected in the spleen, lung, liver, skeletal muscle, kidney and testis. Orexin receptor mRNA expression has also been reported in the adrenal gland, enteric nervous system, and pancreas.
messages: Membrane
messages: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
messages: The N-terminal region is required for orexin signaling.

10116:Klhdc10
gene id: 10116:Klhdc10
uniprot id: Q5U3Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KLHDC10 family.
messages: Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter KLHDC10. Interacts (via the 6 Kelch repeats) with PPP5C.
messages: Cytoplasm
messages: Nucleus
messages: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC10) complex specifically recognizes proteins with a proline-glycine (Pro-Gly) or an alanine tail (CAT tail) at the C-terminus, leading to their ubiquitination and degradation. The CRL2(KLHDC10) complex is involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: CRL2(KLHDC10) acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation. Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5 (By similarity). Acts as a regulator of necroptosis (By similarity).

10116:Ndufs8
gene id: 10116:Ndufs8
uniprot id: B0BNE6
names: Similarity
messages: Belongs to the complex I 23 kDa subunit family.

10116:Pgr
gene id: 10116:Pgr
uniprot id: E0YJE6
uniprot id: E0YJE7
uniprot id: Q63449
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and represses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-344. Interacts with PRMT2 (By similarity). Isoform A interacts with NCOR2. Isoform B (but not isoform A) interacts with NCOA2 and NCOA1 (By similarity). Isoform B (but not isoform A) interacts with KLF9. Interacts with GTF2B (By similarity).
messages: Isoform A and isoform B are expressed in the pituitary.
messages: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.
messages: Nucleus
messages: Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation (By similarity).
messages: Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-293 is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-387. Phosphorylation on Ser-344 also requires induction by hormone. Basal phosphorylation on Ser-82, Ser-190 and Ser-399 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-399 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-293, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-344 by ERK1/2 MAPK is required for interaction with SP1 (By similarity).
messages: Steroid hormone receptor involved in the regulation of eukaryotic gene expression which affects cellular proliferation and differentiation in target tissues.
messages: Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-387, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-293 (By similarity).
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity).
messages: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.
messages: Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-293 (By similarity).

10116:Nmb
gene id: 10116:Nmb
uniprot id: A6JCD9
uniprot id: D4A1W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted
messages: neuron projection

10116:Trim54
gene id: 10116:Trim54
uniprot id: A6HA76
uniprot id: Q5XIH6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homooligomer and heterooligomer. Interacts with TRIM63 and probably with TRIM55. Interacts with tubulin (By similarity).
messages: May bind and stabilize microtubules during myotubes formation.
messages: Z line
messages: cytoskeleton

10116:Psmc6
gene id: 10116:Psmc6
uniprot id: A6KDZ6
uniprot id: G3V6W6
uniprot id: Q32PW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Nucleus

10116:Slc40a1
gene id: 10116:Slc40a1
uniprot id: A6INT8
uniprot id: Q923U9
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Cell membrane
messages: During elevated serum iron levels, liver-derived hepcidin/HAMP negatively regulates cell surface SLC40A1 by inducing its ubiquitination, internalization, and degradation. Indeed, hepcidin/HAMP affinity towards ferroportin/SLC40A1 increases by 80-fold in the presence of iron.
messages: Identified in a complex with STOM. Interacts with HAMP; this interaction promotes SLC40A1 rapid ubiquitination.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Manganese (Mn) transport by SLC40A1 remains controversial. Some in vitro studies have suggested that SLC40A1 transports minimal amounts of Mn(2+) (By similarity). Other groups have suggested that it does not. The affinity of SLC40A1 for manganese is extremely low compared with iron, implying that any SLC40A1-mediated Mn transport in vivo would likely be trivial (By similarity). A recent study examined the role of SLC40A1 in Mn homeostasis by using Tmprss6-O mice, which express high levels of hepcidin/HAMP and therefore have very low SLC40A1 levels in their tissues. These mice show frank iron deficiency and reduced iron levels in most tissues, but manganese levels are largely unaffected (By similarity). These studies suggest that manganese is propably not the physiological substrate of SLC40A1.
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane
messages: Polyubiquitinated by RNF217; leading to proteasomal degradation (By similarity). Ubiquitination is necessary for its internalization by hepcidin/HAMP (By similarity).
messages: Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (By similarity). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (By similarity).

10116:Fancd2
gene id: 10116:Fancd2
uniprot id: Q6IV68
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts directly with FANCE and FANCI. Interacts with USP1 and MEN1. The ubiquitinated form specifically interacts with BRCA1 and BLM. Both the nonubiquitinated and the monoubiquitinated forms interact with BRCA2; this interaction is mediated by phosphorylated FANCG and the complex also includes XCCR3. The ubiquitinated form specifically interacts with MTMR15/FAN1 (via UBZ-type zinc finger), leading to recruit MTMR15/FAN1 to sites of DNA damage. Interacts with DCLRE1B/Apollo. Interacts with POLN. Interacts with UHRF1 and UHRF2; these interactions promote FANCD2 activation.
messages: Monoubiquitinated on Lys-561 during S phase and upon genotoxic stress by FANCL in complex with E2 ligases UBE2T or UBE2W. Deubiquitinated by USP1 as cells enter G2/M, or once DNA repair is completed. Monoubiquitination requires the joint intervention of the FANC core complex, including FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, and FANCM, and proteins involved in cell cycle checkpoints and DNA repair, including RPA1, ATR, CHEK1 and BRCA1, and is mediated by FANCL/PHF9. Ubiquitination is required for binding to chromatin, interaction with BRCA1, BRCA2 and MTMR15/FAN1, DNA repair, and normal cell cycle progression (By similarity).
messages: Nucleus
messages: Phosphorylated on several sites including Ser-222 and Ser-1401 in response to genotoxic stress.
messages: Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching (By similarity).

10116:Mbl2
gene id: 10116:Mbl2
uniprot id: P08661
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).
messages: Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2 (By similarity). Interacts with MEP1A and MEP1B and may inhibit their catalytic activity (By similarity).
messages: Secreted
messages: The coiled-coil domain mediates trimerization.

10116:Vwce
gene id: 10116:Vwce
uniprot id: A0A0G2JYM7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Lix1
gene id: 10116:Lix1
uniprot id: A6KB64
uniprot id: D3ZAG6
names: Similarity
messages: Belongs to the LIX1 family.

10116:Sh3bp1
gene id: 10116:Sh3bp1
uniprot id: D3ZFJ3
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell projection
messages: GTPase activating protein/GAP which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment. It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (By similarity).
messages: Interacts with RAC1. Interacts with the exocyst via EXOC4 and EXOC8; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells. Interacts with CD2AP and CGNL1; probably part of a complex at cell junctions. Interacts with CAPZA1; recruits CAPZA1 to forming cell junctions. May interact with AFDN. Interacts with PLXND1; they dissociate upon SEMA3E binding to PLXND1 allowing SH3BP1 to transduce downstream signal through RAC1 inactivation. Interacts with ABL1, GRB2 and SRC (via SH3 domain).
messages: Nucleus
messages: The BAR domain mediates interaction with the exocyst components EXOC4 and EXOC8 and is required for the function in cell migration. It also mediates the interaction with PLXND1.
messages: adherens junction
messages: cytosol
messages: phagocytic cup
messages: tight junction

10116:Or5p60d
gene id: 10116:Or5p60d
uniprot id: D3ZVM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ctsd
gene id: 10116:Ctsd
uniprot id: A0A8I6AIK0
uniprot id: A6HY44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome
messages: extracellular space

10116:LOC685699
gene id: 10116:LOC685699
uniprot id: A0A8J8YPM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

10116:Fgf6
gene id: 10116:Fgf6
uniprot id: A0A0G2JTJ4
uniprot id: Q8R5L5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

10116:Olr996
gene id: 10116:Olr996
uniprot id: D3ZEF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tspan6
gene id: 10116:Tspan6
uniprot id: A0A8I6A7Q5
uniprot id: B0BN20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

10116:Angel1
gene id: 10116:Angel1
uniprot id: B2RYM0
names: Similarity
messages: Belongs to the CCR4/nocturin family.

10116:F12
gene id: 10116:F12
uniprot id: D3ZTE0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity).
messages: Interacts with HRG; the interaction, which is enhanced in the presence of zinc ions and inhibited by heparin-binding, inhibits factor XII autoactivation and contact-initiated coagulation.
messages: O- and N-glycosylated.
messages: Secreted

10116:Fbxw2
gene id: 10116:Fbxw2
uniprot id: B2RZ17
names: Function
names: Subunit
messages: Directly interacts with SKP1 and CUL1.
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

10116:RT1-CE7
gene id: 10116:RT1-CE7
uniprot id: Q861P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Membrane

10116:Ublcp1
gene id: 10116:Ublcp1
uniprot id: A6HDP3
uniprot id: Q5FWT7
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. Recruited to the 19S regulatory particle of the 26S proteasome through its interaction with 19S component PSMD2/RPN1. Once recruited, dephosphorylates 19S component PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly. Has also been reported to stimulate the proteolytic activity of the 26S proteasome.
messages: Nucleus
messages: The Ubiquitin-like domain mediates interaction with proteasomes.

10116:Adamts8
gene id: 10116:Adamts8
uniprot id: D4AAT1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

10116:Stat5a
gene id: 10116:Stat5a
uniprot id: Q62771
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transcription factor STAT family.
messages: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
messages: Cytoplasm
messages: Detected both in virgin rats and after mammary gland involution. The level of STAT5A increases constantly during pregnancy, but decreases at the onset of lactation and remains lows throughout lactation.
messages: Expressed in heart, lung, and weakly in muscle.
messages: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1. Interacts with NCOA1 and SOCS7. Interacts with ERBB4 (By similarity). Interacts with EBF4.
messages: ISGylated.
messages: Nucleus
messages: Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO (By similarity). Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus (By similarity). Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:22673903). Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2 at Tyr-694 (By similarity).

10116:Cnot10
gene id: 10116:Cnot10
uniprot id: Q5XIA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity).
messages: Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold (By similarity).
messages: Cytoplasm
messages: Nucleus

10116:Tmem45a2
gene id: 10116:Tmem45a2
uniprot id: A0A0G2JYF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

10116:Apoa1
gene id: 10116:Apoa1
uniprot id: P04639
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the apolipoprotein A1/A4/E family.
messages: Glycosylated.
messages: Homodimer (By similarity). Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Interacts with SCGB3A2 (By similarity). Interacts with NAXE and YJEFN3 (By similarity).
messages: Major protein of plasma HDL, also found in chylomicrons.
messages: Palmitoylated.
messages: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
messages: Phosphorylation sites are present in the extracellular medium.
messages: Secreted

10116:Arsj
gene id: 10116:Arsj
uniprot id: A0A8I6GJP1
uniprot id: Q32KJ7
names: Similarity
messages: Belongs to the sulfatase family.

10116:H2aj
gene id: 10116:H2aj
uniprot id: A9UMV8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (By similarity).
messages: Monoubiquitination of Lys-120 (H2AXK119ub) gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties (By similarity).
messages: Nucleus
messages: Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

10116:Lyl1
gene id: 10116:Lyl1
uniprot id: Q66HH3
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

10116:Cdc6
gene id: 10116:Cdc6
uniprot id: A6HIV7
uniprot id: D3ZRK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

10116:Pex7
gene id: 10116:Pex7
uniprot id: Q498S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Peroxisome matrix
messages: cytosol

10116:Adamts10
gene id: 10116:Adamts10
uniprot id: A0A0G2K229
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

10116:Dgat2
gene id: 10116:Dgat2
uniprot id: Q5FVP8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides (By similarity). Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity).
messages: Forms multimeric complexes consisting of several DGAT2 subunits (By similarity). Interacts with SLC27A1 and this interaction is enhanced in the presence of ZFYVE1 (By similarity).
messages: Inhibited by niacin.
messages: Lipid droplet
messages: perinuclear region

10116:Pecam1
gene id: 10116:Pecam1
uniprot id: Q3SWT0
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-660 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes. Modulates bradykinin receptor BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Induces susceptibility to atherosclerosis.
messages: Cell junction
messages: Cell membrane
messages: Membrane raft
messages: Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells and enrichment in membrane rafts.
messages: Phosphorylated on Ser and Tyr residues after cellular activation. In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation. Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation.
messages: The Ig-like C2-type domains 2 and 3 contribute to formation of the complex with BDKRB2 and in regulation of its activity.
messages: Trans-homodimer (via Ig-like C2-type 1 and Ig-like C2-type 2 domains); trans-homodimerization is required for cell-cell interaction. Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ. Interacts with PTPN11. Interacts with FER. Interacts with CD177; the interaction is Ca(2+)-dependent; the interaction is direct.

10116:Afap1l1
gene id: 10116:Afap1l1
uniprot id: D4AB98
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with CTTN.
messages: May be involved in podosome and invadosome formation.
messages: invadopodium
messages: podosome

10116:Zdhhc20
gene id: 10116:Zdhhc20
uniprot id: A0A8I6AR22
uniprot id: Q2TGI6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

10116:Mfsd5
gene id: 10116:Mfsd5
uniprot id: B1WC12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.
messages: Membrane

10116:Herpud2
gene id: 10116:Herpud2
uniprot id: Q66HH4
names: Function
names: Subcellular Location Annotation
messages: Could be involved in the unfolded protein response (UPR) pathway.
messages: Membrane

10116:Glyctk
gene id: 10116:Glyctk
uniprot id: A6I2P3
uniprot id: Q0VGK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerate kinase type-2 family.
messages: Cytoplasm

10116:Hist1h2an
gene id: 10116:Hist1h2an
uniprot id: A6KLN9
uniprot id: G3V9C0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

10116:Sgk1
gene id: 10116:Sgk1
uniprot id: A0A0G2JVM7
uniprot id: D4A128
uniprot id: F1LXA3
uniprot id: Q68G05
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

10116:Or56b1
gene id: 10116:Or56b1
uniprot id: A6I7F9
uniprot id: D4A730
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Izumo4
gene id: 10116:Izumo4
uniprot id: A0A8I5ZSN1
uniprot id: D4ABT2
names: Similarity
messages: Belongs to the Izumo family.

10116:Cebpa
gene id: 10116:Cebpa
uniprot id: A6JAA1
uniprot id: P05554
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Binds DNA as a homodimer and as a heterodimer (PubMed:1884998, PubMed:8367486, PubMed:12578822). Can form stable heterodimers with CEBPB, CEBPD, CEBPE and CEBPG (PubMed:1884998, PubMed:1377818). Can form stable homodimers (also isoform 2 and isoform 3 dimers) and heterodimers with CEBPB (with isoform 2 and isoform 3) and CEBPG (PubMed:1377818, PubMed:8367486). Interacts with PRDM16 (By similarity). Interacts with UBN1 (By similarity). Interacts with ZNF638; this interaction increases transcriptional activation (By similarity). Interacts with the complex TFDP2:E2F1; the interaction prevents CEBPA binding to target gene promoters and represses its transcriptional activity (By similarity). Interacts with RB1 (By similarity). Interacts (when phosphorylated at Ser-193) with CDK2, CDK4, E2F4 and SMARCA2 (By similarity). Interacts with SREBPF1 (By similarity). Interacts with FOXO1 (via the Fork-head domain); the interaction increases when FOXO1 is deacetylated (By similarity). Interacts with SIX1 (By similarity). Interacts (via recognition sequence) with TRIB1 (By similarity).
messages: Can act as dominant-negative. Binds DNA and have transctivation activity, even if much less efficiently than isoform 2. Does not inhibit cell proliferation.
messages: Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation.
messages: Interacts with NPM1.
messages: Interacts with TAF1A and UBTF.
messages: Isoform 2 and isoform 3 are expressed in liver (at protein level).
messages: Isoform 2 and isoform 3 are not expressed at 1 day before birth, relative concentration of both isoforms increases with the age of the animal, reaching maximal levels in the adulthood.
messages: Mutagenesis in position: 14: RRQR -> AAAA abolishes nucleolar localization and prevents induction of 45S pre-RNA.
messages: Nucleus
messages: Phosphorylation at Ser-193 is required for interaction with CDK2, CDK4 and SWI/SNF complex leading to cell cycle inhibition. Dephosphorylated at Ser-193 by protein phosphatase 2A (PP2A) through PI3K/AKT signaling pathway regulation. Phosphorylation at Thr-222 and Thr-226 by GSK3 is constitutive in adipose tissue and lung. In liver, both Thr-222 and Thr-226 are phosphorylated only during feeding but not during fasting. Phosphorylation of the GSK3 consensus sites selectively decreases transactivation activity on IRE-controlled promoters.
messages: Sumoylated, sumoylation blocks the inhibitory effect on cell proliferation by disrupting the interaction with SMARCA2.
messages: The V296A substitution has little effect on the binding of CEBPA to its consensus site (5'-GCAAT-3'), while greatly increasing affinity for cAMP response element (CRE) sites (5'-GTCAT-3').
messages: The recognition sequence (54-72) is required for interaction with TRIB1.
messages: Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta (PubMed:8367486, PubMed:11672531, PubMed:16735515, PubMed:20176812). Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes. During early embryogenesis, plays essential and redundant functions with CEBPB (By similarity). Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP) (PubMed:11672531). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (PubMed:11672531). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Down-regulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters (PubMed:11672531). Proliferation arrest also depends on a functional binding to SWI/SNF complex (By similarity). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity).
messages: Ubiquitinated by COP1 upon interaction with TRIB1.
messages: nucleolus

10116:Il7
gene id: 10116:Il7
uniprot id: Q91Y32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-7/IL-9 family.
messages: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.
messages: Interacts with IL7R and CSF2RG.
messages: Secreted

10116:Arl8b
gene id: 10116:Arl8b
uniprot id: A6IBL4
uniprot id: Q66HA6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cytolytic granule membrane
messages: Endosome membrane
messages: Interacts with tubulin. Interacts with BORCS5; recruits ARL8B to lysosomes. Interacts with VPS41; the interaction mediates the recruitment of the HOPS complex to lysosomes. Interacts (GTP-bound form) with PLEKHM2 (via RUN domain); the interaction is required to recruit the motor protein kinesin-1 on lysosomes. Interacts (GTP-bound form) with PLEKHM1 (via RUN domain); the interaction is required for PLEKHM1 localization to lysosomes and for ARL8B function in delivery and degradation of endocytic and autophagic cargo in lysosomes. PLEKHM1 and PLEKHM2 compete for interaction with ARL8B.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of lysosomal positioning which is important for nutrient sensing, natural killer cell-mediated cytotoxicity and antigen presentation. Along with its effectors, orchestrates lysosomal transport and fusion. Localizes specifically to lysosomal membranes and mediates anterograde lysosomal motility by recruiting PLEKHM2, which in turn recruits the motor protein kinesin-1 on lysosomes. Required for lysosomal and cytolytic granule exocytosis. Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). Also acts as a regulator of endosome to lysosome trafficking pathways of special significance for host defense. Regulates cargo trafficking to lysosomes by binding to PLEKHM1 and recruiting the HOPS subunit VPS41, resulting in functional assembly of the HOPS complex on lysosomal membranes. Plays an important role in cargo delivery to lysosomes for antigen presentation and microbial killing. Directs the intersection of CD1d with lipid antigens in lysosomes, and plays a role in intersecting phagosomes with lysosomes to generate phagolysosomes that kill microbes (By similarity). Involved in the process of MHC II presentation. Regulates the delivery of antigens to lysosomes and the formation of MHC II-peptide complexes through the recruitment of the HOPS complex to lysosomes allowing the fusion of late endosomes to lysosomes (By similarity). May play a role in chromosome segregation (By similarity).
messages: Synapse
messages: Ubiquitinated at Lys-141 by RNF167, leading to its degradation.
messages: axon
messages: spindle

10116:Zranb2
gene id: 10116:Zranb2
uniprot id: A0A0H2UHZ4
uniprot id: A6HWS4
uniprot id: O35986
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ZRANB2 family.
messages: Expressed in kidney; more specifically in renal juxtaglomerular (JG) cells.
messages: Interacts with the C-terminal half of SNRP70/U1-70K, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection (By similarity).
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.
messages: The RanBP2-type zinc fingers mediate binding to RNA.

10116:Pqbp1
gene id: 10116:Pqbp1
uniprot id: Q6PCT5
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasmic granule
messages: Except for the WW domain, the protein is intrinsically disordered.
messages: Interacts with POU3F2/Brn-2, ATXN1, TXNL4A, HTT and AR. Interaction with ATXN1 correlates positively with the length of the polyglutamine tract. Interacts with RNA polymerase II large subunit in a phosphorylation-dependent manner. Forms a ternary complex with ATXN1 mutant and phosphorylated RNA polymerase II. Interacts (via C-terminus) with TXNL4A and CD2BP2. Interacts (via WW domain) with ATN1 and SF3B1, and may interact with additional splice factors. Interacts (via WW domain) with WBP11; Leading to reduce interaction between PQBP1 and TXNL4A. Interacts with CAPRIN1. Interacts with DDX1. Interacts with SFPQ. Interacts with KHSRP.
messages: Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules. Also acts as an innate immune sensor of infection by retroviruses, by detecting the presence of reverse-transcribed DNA in the cytosol. Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production.
messages: Nucleus
messages: Nucleus speckle
messages: The WW domain may play a role as a transcriptional activator directly or via association with the transcription machinery. The WW domain mediates interaction with WBP11, ATN1, SF3B1 and the C-terminal domain of the RNA polymerase II large subunit.

10116:Mtmr1
gene id: 10116:Mtmr1
uniprot id: D3ZKK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

10116:Msmo1
gene id: 10116:Msmo1
uniprot id: O35532
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family.
messages: Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol.
messages: Endoplasmic reticulum membrane
messages: The histidine box domains may contain the active site and/or be involved in metal ion binding.

10116:Or52s1
gene id: 10116:Or52s1
uniprot id: A6I789
uniprot id: D3ZVA3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Pcdhga11
gene id: 10116:Pcdhga11
uniprot id: I6LBW8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

10116:Kitlg
gene id: 10116:Kitlg
uniprot id: A6IG90
uniprot id: P21581
uniprot id: Q54A14
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain.
messages: Acts in the early stages of hematopoiesis.
messages: Belongs to the SCF family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation.
messages: Homodimer, non-covalently linked.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
messages: Secreted
messages: The identity of N- and O-linked saccharides is not reported in PubMed:1708771. The O-linked polysaccharides are probably the mucin type linked to GalNAc.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

10116:Ipmk
gene id: 10116:Ipmk
uniprot id: A0A8L2PZ63
uniprot id: A6JKN6
uniprot id: Q99NI4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the inositol phosphokinase (IPK) family.
messages: Binds two Mg(2+), but the interaction with the protein is mostly indirect.
messages: Highly expressed in kidney, and at lower levels in hippocampus, brain cortex, cerebellum, heart and lung.
messages: Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:11226235). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (By similarity). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:16123124). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (By similarity). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity).
messages: Nucleus

10116:Vegfc
gene id: 10116:Vegfc
uniprot id: A6JPH8
uniprot id: O35757
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors.
messages: Highly expressed in the lung, ovary, preputial gland and the adrenal gland. Expressed in the post-pubertal mammary glands.
messages: Homodimer; non-covalent and antiparallel. Interacts with FLT4/VEGFR3; the interaction is required for FLT4/VEGFR3 homodimarization and activation.
messages: Increases moderately during pregnancy (2.8-fold increase on day 4) and lactation (1.9-fold increase on day 2).
messages: Indolinones; MAE87, MAE106 and MAZ51 inhibit VEGF-C induced activation of VEGFR-3.
messages: Secreted
messages: Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-223 and Ser-224 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions (By similarity).

10116:Gnaz
gene id: 10116:Gnaz
uniprot id: A6JKM2
uniprot id: P19627
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: G-proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with ADGRB2 (By similarity).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
messages: Membrane

10116:Etv6
gene id: 10116:Etv6
uniprot id: Q3KRD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

10116:Eif5b
gene id: 10116:Eif5b
uniprot id: B2GUV7
names: Cofactor
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Binds 1 monovalent cation per monomer in the active site. Structural cofactor that stabilizes the GTP-bound 'on' state. May also act as a transition state stabilizer of the hydrolysis reaction.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Cytoplasm
messages: Interacts through its C-terminal domain (CTD) with the CTD of eIF1A (EIF1AX) or with the CTD of EIF5 (mutually exclusive) through a common binding site. Interacts with eIF1A (EIF1AX) from the location of the start codon by the 43S complex until the formation of the 80S complex (By similarity). Interacts with ANXA5 in a calcium and phospholipid-dependent manner (PubMed:8667030).
messages: Plays a role in translation initiation. Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after formation of the 80S initiation complex. Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes. In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit.

10116:C1h10orf88
gene id: 10116:C1h10orf88
uniprot id: Q5XI46
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10. Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival.
messages: Cytoplasm
messages: Homodimer. Interacts with ABCB7, ABCB8/MITOSUR and ABCB10.
messages: Mitochondrion

10116:Csn1s2b
gene id: 10116:Csn1s2b
uniprot id: A6KU18
uniprot id: Q8CGR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the alpha-casein family.
messages: Important role in the capacity of milk to transport calcium phosphate.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted

10116:Enpp2
gene id: 10116:Enpp2
uniprot id: A6HRG3
uniprot id: Q64610
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abundantly expressed in cerebrum and cerebellum. Localized in secretory epithelial cells in the brain and the eye including choroid plexus epithelial cells, ciliary epithelial cells, iris pigment epithelial cells, and retinal pigment cells.
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:12633853, PubMed:29259743, PubMed:27660691, PubMed:27268273, PubMed:27075612, PubMed:12354767). Major substrate is lysophosphatidylcholine (PubMed:12119361, PubMed:27660691, PubMed:27268273, PubMed:27075612, PubMed:12176993). Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility (PubMed:12119361). Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:12633853, PubMed:27268273). Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor (By similarity). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (By similarity). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity).
messages: Inhibited by vanadate (PubMed:27268273). Inhibited by micromolar levels of bile salts, such as tauroursodeoxycholate. Not inhibited by taurodeoxycholate. Not inhibited by hydroxysterols, such as 7-hydroxycholesterol, testosterone, dexamethasone and prednisolone (PubMed:27075612). Inhibited by EDTA and EGTA (PubMed:12354767).
messages: N-glycosylation, but not furin-cleavage, plays a critical role on secretion and on lysoPLD activity.
messages: Secreted
messages: The interdomain disulfide bond between Cys-413 and Cys-830 is essential for catalytic activity.

10116:Mrps18c
gene id: 10116:Mrps18c
uniprot id: A6K5X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

10116:Tinagl1
gene id: 10116:Tinagl1
uniprot id: A6ISN5
uniprot id: F7F528
uniprot id: Q9EQT5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Glycosylated.
messages: May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity).
messages: Secreted

10116:Scrn2
gene id: 10116:Scrn2
uniprot id: Q6AYR8
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

10116:Rxfp3
gene id: 10116:Rxfp3
uniprot id: A6KJS0
uniprot id: F7EK20
names: Subcellular Location Annotation
messages: Membrane

10116:Clcn3
gene id: 10116:Clcn3
uniprot id: A6KIS2
uniprot id: P51792
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in brain, especially in the olfactory bulb, hippocampus, and cerebellum. A moderate expression is seen in the lung, kidney and adrenal gland.
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Monomer and homodimer (By similarity). Forms heterodimers with CLCN4 (By similarity).
messages: N-glycosylated.
messages: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:10915634). May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C (PubMed:8155321). It could help neuronal cells to establish short-term memory (PubMed:8155321).
messages: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:10915634). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity).

10116:Acrbp
gene id: 10116:Acrbp
uniprot id: Q6AY33
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation.
messages: Binds pro-ACR. Does not bind mature form of ACR.
messages: Binds pro-ACR. Does not bind the mature form of ACR.
messages: Maintains pro-ACR as an enzymatically inactive zymogen in the acrosome until acrosomal exocytosis. Partially contributes also to the assembly of acrosomal proteins to form an acrosomal granule.
messages: Phosphorylated on Tyr residues in capacitated sperm.
messages: Rodent specific isoform that participates in the formation of the acrosomal granule into the center of the acrosomal vesicle during early spermiogenesis. In the fertilization process promotes ACR release from the acrosome during acrosomal exocytosis.
messages: Synthesized as a 60-kDa precursor, the 32-kDa mature form is post-translationally produced by the removal of the N-terminal half of the precursor during sperm maturation in the testis and/or epididymis.
messages: The N-terminus is blocked.
messages: acrosome

10116:Prps2
gene id: 10116:Prps2
uniprot id: A0A8L2Q1L2
uniprot id: A6K2F9
uniprot id: P09330
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by magnesium and inorganic phosphate.
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity).
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

10116:Serpina10
gene id: 10116:Serpina10
uniprot id: A6JEN8
uniprot id: Q62975
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the serpin family.
messages: Expressed by the liver and secreted in plasma.
messages: Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa.
messages: In regenerating livers, it showed maximal expression 48 hours after hepatectomy, expression remaining elevated up to 2 weeks after liver removal.
messages: Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors (By similarity).
messages: Phosphorylated by FAM20C in the extracellular medium.
messages: Secreted

10116:Mef2c
gene id: 10116:Mef2c
uniprot id: A0A096MJY4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation.
messages: Belongs to the MEF2 family.
messages: Expressed in the heart (PubMed:15862299). Expressed in cardiac myocytes (at protein level) (PubMed:15862299).
messages: Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with EP300 in differentiating cells; the interaction acetylates MEF2C leading to increased DNA binding and activation. Interacts with HDAC7 and CARM1. Interacts with HDAC4 and HDAC9; the interaction with HDACs represses transcriptional activity. Interacts with LPIN1. Interacts with MYOCD. Interacts with AKAP13. Interacts with FOXK1; the interaction inhibits MEF2C transactivation activity (By similarity). Interacts (via N-terminus) with HABP4; this interaction decreases DNA-binding activity of MEF2C in myocardial cells in response to mechanical stress (PubMed:15862299). Interacts with JPH2; interaction specifically takes place with the Junctophilin-2 N-terminal fragment cleavage product of JPH2 (By similarity). Interacts (via MADS box) with SOX18 (By similarity).
messages: Nucleus
messages: Phosphorylated on Ser-59; which enhances DNA binding activity. Phosphorylated on Ser-396; which is required for Lys-391 sumoylation and inhibits transcriptional activity.
messages: Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 3 and caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.
messages: Sumoylated on Lys-391 with SUMO2 but not SUMO1; which represses transcriptional activity.
messages: The beta domain is required for enhancement of transcriptional activity.
messages: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes (PubMed:15862299). Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity).
messages: sarcoplasm

10116:Or4d10c
gene id: 10116:Or4d10c
uniprot id: A6I0C3
uniprot id: D3ZSJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Gabra5
gene id: 10116:Gabra5
uniprot id: A6KD38
uniprot id: P19969
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA5 sub-subfamily.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
messages: Ligand-gated chloride channel subunit which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. May be involved in GABA-A receptor assembly, and GABA-A receptor immobilization and accumulation by gephyrin at the synapse.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

10116:Ctsa
gene id: 10116:Ctsa
uniprot id: A6JXC2
uniprot id: F7EU44
names: Similarity
messages: Belongs to the peptidase S10 family.

10116:Fbp2
gene id: 10116:Fbp2
uniprot id: A6KQB2
uniprot id: Q9Z1N1
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.
messages: Cell junction
messages: Cytoplasm
messages: Homotetramer. Interacts with ALDOA; the interaction blocks inhibition by physiological concentrations of AMP and reduces inhibition by Ca(2+). Interacts with alpha-actinin and F-actin (By similarity).
messages: Nucleus
messages: Subject to complex allosteric regulation. The enzyme can assume an active R-state, or an inactive T-state. Intermediate conformations may exist. AMP acts as allosteric inhibitor. Fructose 2,6-bisphosphate acts as competitive inhibitor. Strongly inhibited by Ca(2+) (By similarity).
messages: Z line

10116:Tmcc3
gene id: 10116:Tmcc3
uniprot id: A0A8I5Y957
uniprot id: A0A8I5ZPM9
uniprot id: A6IG16
uniprot id: A6IG18
uniprot id: A6IG20
uniprot id: D3ZLE2
names: Similarity
messages: Belongs to the TEX28 family.

10116:Syt16
gene id: 10116:Syt16
uniprot id: A0A0G2K644
names: Similarity
messages: Belongs to the synaptotagmin family.

10116:Phpt1
gene id: 10116:Phpt1
uniprot id: A6JT83
names: Function
names: Similarity
messages: Belongs to the janus family.
messages: Exhibits phosphohistidine phosphatase activity.

10116:LOC102551265
gene id: 10116:LOC102551265
uniprot id: A0A8I6AII0
uniprot id: D3Z9T8
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

10116:Or12d13
gene id: 10116:Or12d13
uniprot id: A0A8I6ABK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ccdc167
gene id: 10116:Ccdc167
uniprot id: A6JJW2
names: Subcellular Location Annotation
messages: Membrane

10116:Dnajc27
gene id: 10116:Dnajc27
uniprot id: Q6IML7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).
messages: Nucleus

10116:Fbxo34
gene id: 10116:Fbxo34
uniprot id: A0A0G2JV06
uniprot id: A6KE53
uniprot id: B5DF06
uniprot id: G3V7J6
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

10116:Prrx1
gene id: 10116:Prrx1
uniprot id: A6IDB7
uniprot id: P63014
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity).
messages: Belongs to the paired homeobox family.
messages: Nucleus

10116:Isca2
gene id: 10116:Isca2
uniprot id: A6JDY3
uniprot id: D4A4L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

10116:Pde2a
gene id: 10116:Pde2a
uniprot id: A0A8I5ZM10
uniprot id: A6I6U9
uniprot id: Q01062
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions.
messages: Binds 2 divalent metal cations per subunit. Site 2 has a preference for magnesium ions.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in brain and liver.
messages: Homodimer.
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Mitochondrion outer membrane
messages: Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of Dnm1l (PubMed:28463107).
messages: The 3',5'-cyclic-AMP phosphodiesterase activity is stimulated by 3',5'-cyclic GMP (By similarity). Specifically inhibited by Bay 60-7550. When repressed, protected from ionomycin- but not staurosporin-induced cell death.
messages: The GAF 1 domain functions as a dimerization domain.
messages: The GAF 2 domains binds cGMP, which acts as an allosteric activator.
messages: cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP (By similarity). Plays a role in cell growth and migration (By similarity).

10116:Ahcyl1
gene id: 10116:Ahcyl1
uniprot id: A0A140TAI8
uniprot id: B5DFN2
names: Caution
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Endoplasmic reticulum
messages: Expressed in kidney proximal tubules and outer medulla (at protein level) (PubMed:20584908).
messages: Forms multimers (By similarity). Forms heteromultimers with AHCYL2 (via the C-terminal region). Interacts (when phosphorylated) with ITPR1 (when not phosphorylated); the interaction suppresses inositol 1,4,5-trisphosphate binding to ITPR1 (By similarity). Interacts with BCL2L10; this strengthens the interaction of AHCYL1 with ITPR1 (By similarity). Interacts with CFTR and SLC26A6; the interactions take place once AHCYL1 is released from ITPR1 and increase CFTR and SLC26A6 activities (By similarity). Interacts with RRM1; in a phosphorylation- and (dATP)-dependent manner. Interacts (via PEST domain when phosphorylated) with SLC4A4 isoform 1 but not isoform 2; the interaction increases SLC4A4 isoform 1 activity. Interacts (when phosphorylated) with SLC9A3; the interaction is required for SLC9A3 apical location and activity (PubMed:20584908). Interacts (when phosphorylated) with FIP1L1; the interaction is direct and associates AHCYL1 with the CPSF complex and RNA. Interacts with PAPOLA (By similarity). Interacts with ZCCHC4 (By similarity). Interacts with AHCY (By similarity).
messages: In spite of its similarity with AHCY, which catalyzes the reversible hydrolysis of S-adenosyl-L-homocysteine to adenosine and homocysteine, recombinant AHCYL1 expressed in bacteria shows no hydrolase activity, nor does it affect the enzyme activity of AHCY.
messages: Microsome
messages: Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (By similarity). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (By similarity). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (By similarity). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (By similarity). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition. May modulate the polyadenylation state of specific mRNAs, …
messages: Phosphorylated at Ser/Thr residues between Ser-21 and Thr-25 in the PEST region: required for interaction with dATP-bound RRM1 and ITPR1. Phosphorylation at Ser-21 by PRKD1 and CAMK4 is required for further phosphorylations by CSNK1A1. Phosphorylation is induced by oxidative stress. Probably phosphorylated by CAMK2A; phosphorylation at Ser-21 may be required for interaction with SLC9A3. Dephosphorylated in response to apoptotic stress conditions which causes translocation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes and promotes apoptosis.
messages: The PEST region is essential for the interaction with ITPR1, and, when phosphorylated, is also the RRM1-binding region. The PDZ-binding region is required for maximal interaction with ITPR1 and is also responsible for the IP3-insensitive interaction with ITPR1 (By similarity).
messages: cytosol

10116:Cfhr2
gene id: 10116:Cfhr2
uniprot id: A0A8I6AN28
uniprot id: A0A8I6ATZ0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Nup62
gene id: 10116:Nup62
uniprot id: P17955
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin NSP1/NUP62 family.
messages: Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUP58 (PubMed:8707840). Interacts with NUP88 (By similarity). Interacts with NUTF2 (PubMed:8707840). Interacts with HIKESHI (By similarity). Interacts with OSBPL8 (By similarity). Interacts with CAPG (By similarity). Interacts with SAS6 and TUBG1 at the centrosome (By similarity). Interacts with MCM3AP (By similarity).
messages: Contains FG repeats.
messages: Essential component of the nuclear pore complex (PubMed:2190987, PubMed:8707840). The N-terminal is probably involved in nucleocytoplasmic transport (By similarity). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (By similarity). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (By similarity). It might be involved in protein recruitment to the centrosome after nuclear breakdown (By similarity).
messages: Nucleus envelope
messages: The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC.
messages: centrosome
messages: nuclear pore complex
messages: spindle pole

10116:Col3a1
gene id: 10116:Col3a1
uniprot id: P13941
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fibrillar collagen family.
messages: Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity).
messages: O-glycosylated.
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).
messages: Trimers of identical alpha 1(III) chains. The chains are linked to each other by interchain disulfide bonds. Trimers are also cross-linked via hydroxylysines. Interacts with ADGRG1 (By similarity).
messages: extracellular matrix

10116:Cacfd1
gene id: 10116:Cacfd1
uniprot id: D4A9I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel flower family.
messages: Membrane

10116:Gyg1
gene id: 10116:Gyg1
uniprot id: O08730
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.
messages: Divalent metal ions. Required for self-glucosylation. Manganese is the most effective.
messages: Homodimer. Interacts (via C-terminus) with glycogen synthase GYS1 (By similarity). Interacts (via C-terminus) with glycogen synthase GYS2 (By similarity). This interaction is required for GYS2-mediated glycogen synthesis (By similarity).
messages: Phosphorylated.
messages: Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
messages: Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-195.

10116:Usp4
gene id: 10116:Usp4
uniprot id: A6I350
uniprot id: B2GUZ1
uniprot id: M0R851
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase C19 family.
messages: Belongs to the peptidase C19 family. USP4 subfamily.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins. Deubiquitinates PDPK1. Deubiquitinates TRIM21. Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface. Deubiquitinates HAS2. Deubiquitinates RHEB in response to EGF signaling, promoting mTORC1 signaling. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER.
messages: Expressed in hippocampus and striatum (at protein level).
messages: Interacts with RB1 (both dephosphorylated and hypophosphorylated forms) (By similarity). Interacts with RBL1 and RBL2 (By similarity). Interacts with ADORA2A (via cytoplasmic C-terminus); the interaction is direct. Interacts with SART3; recruits USP4 to its substrate PRPF3 (By similarity).
messages: Monoubiquitinated by TRIM21. Ubiquitination does not lead to its proteasomal degradation. Autodeubiquitinated.
messages: Nucleus
messages: Phosphorylated at Ser-445 by PKB/AKT1 in response to EGF stimulus, promoting its ability deubiquitinate RHEB.
messages: The DUSP and ubiquitin-like 1 domains promote ubiquitin release and thus enhance USB4 catalytic activity. However, these domains do not bind ubiquitin.
messages: The completion of the deubiquitinase reaction is mediated by the DUSP and ubiquitin-like 1 domains which promotes the release of ubiquitin from the catalytic site enabling subsequent reactions to occur.

10116:Osbpl11
gene id: 10116:Osbpl11
uniprot id: A0A8I6A240
uniprot id: A6IRL8
uniprot id: F7FPV5
names: Similarity
messages: Belongs to the OSBP family.

10116:Or1e21
gene id: 10116:Or1e21
uniprot id: A0A8I6AWI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:RGD1309808
gene id: 10116:RGD1309808
uniprot id: A0A0G2JW05
uniprot id: M0R498
names: Similarity
messages: Belongs to the apolipoprotein L family.

10116:Slc25a19
gene id: 10116:Slc25a19
uniprot id: Q6AYL0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient.
messages: Mitochondrion membrane
messages: Previously identified as the mitochondrial deoxyribonucleotide carrier (By similarity). However other experiments later demonstrated that SLC25A19 is a thiamine diphosphate transporter and not a mitochondrial deoxyribonucleotide carrier (By similarity).
messages: Previously identified as the mitochondrial deoxyribonucleotide carrier. However other experiments later demonstrated that SLC25A19 is a thiamine diphosphate transporter and not a mitochondrial deoxyribonucleotide carrier.

10116:Or5p5
gene id: 10116:Or5p5
uniprot id: D3ZNI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Nr1d2
gene id: 10116:Nr1d2
uniprot id: A6K037
uniprot id: Q63504
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Binds DNA as a monomer or a homodimer (By similarity). Interacts with NCOA5 coactivator, leading to a strong increase of transcription of target genes (By similarity). Interacts (via N-terminus) with KAT5 (By similarity). Interacts (via C-terminus) with HDAC1 (By similarity). Interacts with ZNHIT1 (By similarity). Interacts with SIAH2 (By similarity).
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Deacetylated by HDAC1 (By similarity). Acetylation and deacetylation regulate its transcriptional regulatory activity (By similarity).
messages: Nucleus
messages: Phosphorylated by CSNK1E; phosphorylation enhances its cytoplasmic localization.
messages: The heme-bound form can bind gaseous signaling molecules such as CO and nitric oxide (NO) and NO can reverse its transcriptional repressor activity.
messages: Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). In addition to its activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle (By similarity). Plays a role in the regulation of circadian sleep/wake cycle; essential for maintaining wakefulness during the dark phase or active period (By similarity). Key regulator of skeletal muscle mitochondrial functio…
messages: Ubiquitinated by SIAH2; leading to its proteasomal degradation.
messages: Under more reducing intracellular redox conditions, Cys-383 is in its heme-bound state, which is optimal for recruitment of the NCOR1/HDAC3 corepressor complex and repression of target genes (By similarity). When subjected to oxidative stress conditions, Cys-383 undergoes oxidation to form a disulfide bridge with Cys-373, also triggering a ligand switch that results in release of bound heme and derepression of target genes (By similarity).

10116:Rida
gene id: 10116:Rida
uniprot id: P52759
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex (PubMed:10400702). Acts by bridging YTHDF2 and the ribonuclease P/MRP complex (By similarity). RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage (By similarity).
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Cytoplasm
messages: Homotrimer. Interacts with YTHDF2.
messages: Liver and kidney.
messages: Mitochondrion
messages: Nucleus
messages: Peroxisome

10116:Actn4
gene id: 10116:Actn4
uniprot id: A0A0G2K013
uniprot id: A6J9M1
uniprot id: Q9QXQ0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the alpha-actinin family.
messages: Cell junction
messages: Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif that mediates interaction with nuclear receptors.
messages: Cytoplasm
messages: Expressed in the foot process layer of podocytes in the kidney glomerulus but not in tubules (at protein level).
messages: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA.
messages: Homodimer; antiparallel. Interacts with MAGI1 (By similarity). Interacts with MICALL2 (preferentially in opened conformation); stimulated by RAB13 activation (By similarity). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (By similarity). Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3 (By similarity). Binds TRIM3 at the N-terminus (By similarity). Interacts with PDLIM2 (PubMed:15505042). Identified in a complex with CASK, IQGAP1, MAGI2, NPHS1, SPTAN1 and SPTBN1 (PubMed:15994232). Interacts with PPARG and RARA (By similarity). Binds to VCL; this interaction triggers VCL conformational changes (By similarity). Interacts with SEPTIN14 (By similarity).
messages: Nucleus
messages: perinuclear region
messages: stress fiber

10116:Gins3
gene id: 10116:Gins3
uniprot id: A6JY01
uniprot id: D3Z9I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

10116:Ltb4r
gene id: 10116:Ltb4r
uniprot id: A6KH52
uniprot id: Q9R0Q2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Exclusively expressed in polymorphonuclear leukocytes.
messages: Membrane
messages: Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.
messages: Receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

10116:Or5p68
gene id: 10116:Or5p68
uniprot id: D4ADA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Zfp394
gene id: 10116:Zfp394
uniprot id: Q498N6
uniprot id: Q9Z2K3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

10116:Or5ac15
gene id: 10116:Or5ac15
uniprot id: A6IQJ8
uniprot id: D3ZPR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Gpr183
gene id: 10116:Gpr183
uniprot id: D4A7K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (By similarity). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (By similarity). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (By similarity). Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (By s…
messages: Homodimer and heterodimer. Heterodimerizes with CXCR5; leading to modulate the interaction between of CXCL13 and CXCR5.

10116:Stard3
gene id: 10116:Stard3
uniprot id: A0A9K3Y7H2
uniprot id: Q5U2T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

10116:Tgoln2
gene id: 10116:Tgoln2
uniprot id: P19814
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with neurabin-1 and neurabin-2. Binds preferentially to the dimeric form of neurabin-1.
messages: trans-Golgi network membrane

10116:Tsc1
gene id: 10116:Tsc1
uniprot id: Q9Z136
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the TSC-TBC complex (also named Rhebulator complex), composed of 2 molecules of TSC1, 2 molecules of TSC2 and 1 molecule of TBC1D7 (PubMed:9809973) (Probable). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (By similarity). Forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23 (By similarity). Forms a complex containing HSP90AA1, TSC1 and TSC2; TSC1 is required to recruit TCS2 to the complex (By similarity). Interacts (via C-terminus) with the closed form of HSP90AA1 (via the middle domain and TPR repeat-binding motif) (By similarity). Interacts with DOCK7 (By similarity). Interacts with FBXW5 (By similarity). Interacts with WDR45B. Interacts with RPAP3 and URI1 (By similarity).
messages: Highly expressed in brain, spleen and kidney, followed by liver and heart.
messages: Lysosome membrane
messages: Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (By similarity). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (By similarity). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (By similarity). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (By similarity). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:16707451). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (PubMed:16707451). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (By similarity). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (By similarity). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (By similarity).
messages: Phosphorylation at Ser-505 does not affect interaction with TSC2.
messages: The C-terminal putative coiled-coil domain is necessary for interaction with TSC2.
messages: cytosol

10116:Nkx2-6
gene id: 10116:Nkx2-6
uniprot id: B1H280
names: Subcellular Location Annotation
messages: Nucleus

10116:Tpm4
gene id: 10116:Tpm4
uniprot id: A6K9Q7
uniprot id: P09495
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tropomyosin family.
messages: Binds to actin filaments in muscle and non-muscle cells (PubMed:7568216). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (By similarity). Smooth muscle contraction is regulated by interaction with caldesmon (By similarity). In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (By similarity).
messages: Homodimer (PubMed:7568216). Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain (PubMed:7568216).
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: cytoskeleton

10116:Ugt2b10
gene id: 10116:Ugt2b10
uniprot id: D4A132
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

10116:Chst7
gene id: 10116:Chst7
uniprot id: A6JZU6
uniprot id: Q6XQG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc (By similarity).

10116:Or8w1
gene id: 10116:Or8w1
uniprot id: A0A8I6ARJ4
uniprot id: A6HMZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:ND2
gene id: 10116:ND2
uniprot id: P11662
uniprot id: Q8HID0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242 (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

10116:Idh2
gene id: 10116:Idh2
uniprot id: A6JC81
uniprot id: P56574
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-413 dramatically reduces catalytic activity. Deacetylated by SIRT3 (By similarity).
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Homodimer.
messages: Mitochondrion
messages: On the 2D-gel the determined pI of this protein (spot P8) is: 9.0, its MW is: 42 kDa.
messages: Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.

10116:Dpm3
gene id: 10116:Dpm3
uniprot id: A6J6D9
uniprot id: D3ZIJ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

10116:Olr1022
gene id: 10116:Olr1022
uniprot id: A0A8I6AIB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ndufv3
gene id: 10116:Ndufv3
uniprot id: A6JJZ9
uniprot id: A6JK00
uniprot id: G3V644
uniprot id: O54755
uniprot id: Q6PCU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
messages: Mitochondrion inner membrane

10116:Dip2b
gene id: 10116:Dip2b
uniprot id: A0A0G2JY22
names: Similarity
messages: Belongs to the DIP2 family.

10116:Letm2
gene id: 10116:Letm2
uniprot id: Q5PQQ5
names: Caution
names: Developmental Stage
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Despite its name, it does not contain any EF-hand domains.
messages: Expressed in the developmental stages from spermatocyte to spermatozoon.
messages: Mitochondrion inner membrane
messages: Testis and sperm.

10116:Or2a7
gene id: 10116:Or2a7
uniprot id: A6IFA1
uniprot id: G3V6P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Secisbp2
gene id: 10116:Secisbp2
uniprot id: Q9QX72
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.
messages: Interacts with SELB.
messages: Nucleus
messages: Ubiquitous.

10116:Barx1
gene id: 10116:Barx1
uniprot id: A6J6Y6
uniprot id: D3ZA67
names: Subcellular Location Annotation
messages: Nucleus

10116:Or2q1
gene id: 10116:Or2q1
uniprot id: A6IF95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Cog7
gene id: 10116:Cog7
uniprot id: A6I8V2
uniprot id: Q3T1G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG7 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

10116:Nbr1
gene id: 10116:Nbr1
uniprot id: A0A0G2K0K7
uniprot id: A6HJD4
uniprot id: F1LSE5
uniprot id: Q501R9
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homooligomer and heterooligomer (By similarity). Interacts with TRIM55 (PubMed:15802564). Interacts with titin/TTN (PubMed:15802564). Interacts with RNF29, USP8, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2 (By similarity). Binds to ubiquitin and ubiquitinated proteins (By similarity). Interacts with SQSTM1 (PubMed:15802564). Interacts with TAX1BP1 (By similarity). Interacts with IRF3; this interaction mediates autophagic degradation of IRF3 (By similarity). Interacts with IL12A and IL12B (By similarity).
messages: Lysosome
messages: M line
messages: Phosphorylated by GSK3A; this phosphorylation inhibits NBR1 involvement in the formation of ubiquitinated protein aggregates.
messages: The PB1 domain mediates interaction with SQSTM1.
messages: Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis. Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (By similarity). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Plays also non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity).
messages: autophagosome

10116:Usp42
gene id: 10116:Usp42
uniprot id: D3ZU96
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme which may play an important role during spermatogenesis.

10116:Crybg3
gene id: 10116:Crybg3
uniprot id: M0RDY6
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

10116:Olr1029
gene id: 10116:Olr1029
uniprot id: A0A8I6G9L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Pgm3
gene id: 10116:Pgm3
uniprot id: A0A9K3Y705
uniprot id: A6I1U8
uniprot id: B2RYN0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.

10116:Prr5
gene id: 10116:Prr5
uniprot id: Q5FVG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PROTOR family.
messages: Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR (By similarity). Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and RICTOR within the TORC2 complex (By similarity).
messages: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-421'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer (By similarity).

10116:Polr2l
gene id: 10116:Polr2l
uniprot id: A6HY08
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

10116:Tm6sf1
gene id: 10116:Tm6sf1
uniprot id: A0A0G2JZS3
uniprot id: A6JCI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Membrane

10116:Oas1e
gene id: 10116:Oas1e
uniprot id: Q5MYX0
names: Similarity
messages: Belongs to the 2-5A synthase family.

10116:Olr1230
gene id: 10116:Olr1230
uniprot id: A0A8I6AWF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Rad23b
gene id: 10116:Rad23b
uniprot id: A6KDQ3
uniprot id: Q4KMA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAD23 family.
messages: Component of the XPC complex composed of XPC, RAD23B and CETN2. Interacts with NGLY1 and PSMC1. Interacts with ATXN3. Interacts with AMFR. Interacts with VCP; the interaction is indirect and mediated by NGLY1 (By similarity).
messages: Cytoplasm
messages: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with Cetn2 appears to stabilize Xpc. May protect Xpc from proteasomal degradation (By similarity).
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome (By similarity).
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus
messages: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, Xpa, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. Xpc:Rad22b induces a bend in DNA upon binding. Xpc:Rad23b stimulates the activity of DNA glycosylases Tdg and Smug1 (By similarity).

10116:Dtd2
gene id: 10116:Dtd2
uniprot id: A6HBI1
uniprot id: F7FIM5
names: Similarity
messages: Belongs to the DTD family.

10116:Gpcpd1
gene id: 10116:Gpcpd1
uniprot id: A6HQG6
uniprot id: Q80VJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.
messages: May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity.
messages: cytosol

10116:Syt13
gene id: 10116:Syt13
uniprot id: Q925B5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the synaptotagmin family.
messages: Expressed in brain, spleen, kidney and testis.
messages: Interacts with NRXN1.
messages: May be involved in transport vesicle docking to the plasma membrane.
messages: Membrane
messages: The first C2 domain/C2A does not mediate Ca(2+)-dependent phospholipid binding.
messages: The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present.

10116:Klf10
gene id: 10116:Klf10
uniprot id: O08876
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Sp1 C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity.
messages: Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
messages: Up-regulated in response to glucose.

10116:Rab32
gene id: 10116:Rab32
uniprot id: A6JP36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

10116:Jph1
gene id: 10116:Jph1
uniprot id: A6JF93
uniprot id: D3ZQ55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

10116:Plppr3
gene id: 10116:Plppr3
uniprot id: B3DM92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

10116:Rtn4rl2
gene id: 10116:Rtn4rl2
uniprot id: Q80WD1
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Nogo receptor family.
messages: Cell membrane
messages: Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (PubMed:15673660). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system (By similarity). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (PubMed:26335717). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).
messages: Detected in adult brain, in neocortex, hippocampus, striatum and dorsal root ganglion neurons, and in retina (at protein level) (PubMed:15673660). In brain, detected in cerebral cortex and hippocampus. Weak or no expression detected in the cerebellum, thalamus or striatum (PubMed:12694398).
messages: Expression is high in adult, but very low in neonate dorsal root ganglion neurons (at protein level).
messages: Interaction with MAG is controversial, and may be indirect (Probable). Interacts with MAG (PubMed:15673660, PubMed:19420245, PubMed:21308849). Does not interact with OMG and RTN4 (PubMed:15673660).
messages: Membrane raft
messages: N-glycosylated (PubMed:19420245, PubMed:21308849). O-glycosylated (PubMed:19420245). Contains terminal sialic acid groups on its glycan chains (PubMed:19420245).
messages: Perikaryon
messages: Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; is released both as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein.
messages: axon
messages: dendrite

10116:St6gal1
gene id: 10116:St6gal1
uniprot id: F2Z3S3
uniprot id: P13721
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 29 family.
messages: Expressed in hepatocytes (at protein level) (PubMed:3121604, PubMed:11278697). Strongly expressed in liver, spleen, lung, kidney and submaxillary gland and weakly in heart and brain (PubMed:1733948, PubMed:2793863).
messages: Expressed in kidney, but not in liver.
messages: Expressed in liver.
messages: Golgi stack membrane
messages: Homodimer (By similarity). Monomer in its soluble form (PubMed:11278697).
messages: Membrane
messages: N-glycosylated.
messages: Produced by alternative promoter usage. The alternative promoter is active in kidney.
messages: Produced by alternative splicing of isoform RKA.
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.
messages: Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.

10116:Hoatz
gene id: 10116:Hoatz
uniprot id: A6J4G8
uniprot id: D4A4Q6
names: Similarity
messages: Belongs to the HOATZ family.

10116:Il5
gene id: 10116:Il5
uniprot id: Q9R2C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-5 family.
messages: Homodimer; disulfide-linked.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
messages: Secreted

10116:Pabpc6
gene id: 10116:Pabpc6
uniprot id: B5DF80
uniprot id: F7FIM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

10116:Eif5a2
gene id: 10116:Eif5a2
uniprot id: A6IHJ3
uniprot id: G3V7J7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

10116:Nkain4
gene id: 10116:Nkain4
uniprot id: A0A0G2KAP3
uniprot id: A6KM71
uniprot id: D4A8K5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Oog1
gene id: 10116:Oog1
uniprot id: F1M886
names: Similarity
messages: Belongs to the PRAME family.

10116:Notch1
gene id: 10116:Notch1
uniprot id: Q07008
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Expressed in the brain, kidney and spleen. Expressed in postnatal central nervous system (CNS) germinal zones and, in early postnatal life, within numerous cells throughout the CNS. Found in both subventricular and ventricular germinal zones.
messages: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination (By similarity). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (By similarity). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (By similarity). Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus (By similarity). Important for follicular differentiation and possibly cell fate selection within the follicle (By similarity). During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia (PubMed:11182080). Represses neuronal and myogenic differentiation (By similarity). May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation (By similarity). May be involved in mesoderm development, somite formation and neurogenesis (By similarity). May enhance HIF1A function by sequestering HIF1AN away from HIF1A (By similarity). Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury (By similarity). Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity).
messages: Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. Notch 1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Forms a trimeric complex with FBXW7 and SGK1. Interacts with HIF1AN. HIF1AN negatively regulates the function of notch intracellular domain (NICD), accelerating myogenic differentiation. Interacts (via NICD) with SNAI1 (via zinc fingers); the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion. Interacts (via NICD) with MDM2A. Interacts (via NICD) with BCL6; the interaction decreases MAML1 recruitment by NOTCH1 NICD on target genes DNA and inhibits NOTCH1 transcractivation activity (By similarity). Interacts with THBS4 (By similarity). Interacts (via the EGF-like repeat region) with CCN3 (via CTCK domain) (By similarity). Interacts (via EGF-like domains) with DLL4 (via N-terminal DSL and MNNL domains) (PubMed:25700513). Interacts with ZMIZ1 (By similarity). Interacts (via NICD domain) with MEGF10 (via the cytoplasmic domain). Interacts with DLL1 and JAG1 (By similarity). Interacts (via NICD domain) with PRAG1 (By similarity). Forms a complex with PRAG1, N1ICD and MAML1, in a MAML1-dependent manner (By similarity). Interacts (via transmembrane region) with PSEN1; the interaction is direct (By similarity). Interacts with ZFP64 (By similarity).
messages: Hydroxylated at Asn-1945 and Asn-2012 by HIF1AN. Hydroxylation reduces affinity for HI1AN and may thus indirectly modulate negative regulation of NICD (By similarity).
messages: In the embryo, highest levels occur between days 12 and 14 and decrease rapidly to much lower levels in the adult.
messages: Interaction with PSEN1 causes partial unwinding of the transmembrane helix, facilitating access to the scissile peptide bond.
messages: Nucleus
messages: O-glycosylated on the EGF-like domains. O-glucosylated at Ser-435 by KDELC1 and KDELC2 (By similarity). Contains both O-linked fucose and O-linked glucose in the EGF-like domains 11, 12 and 13, which are interacting with the residues on DLL4 (PubMed:25700513). O-linked glycosylation by GALNT11 is involved in determination of left/right symmetry: glycosylation promotes activation of NOTCH1, possibly by promoting cleavage by ADAM17, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). MFNG-, RFNG- and LFNG-mediated modification of O-fucose residues at specific EGF-like domains results in inhibition of its activation by JAG1 and enhancement of its activation by DLL1 via an increased binding to DLL1 (By similarity).
messages: Phosphorylated.
messages: Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by ADAM17 to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). Following endocytosis, this fragment is then cleaved by one of the catalytic subunits of gamma-secretase (PSEN1 or PSEN2) to release a Notch-derived peptide containing the intracellular domain (NICD) from the membrane.
messages: Ubiquitinated. Undergoes 'Lys-29'-linked polyubiquitination by ITCH; promotes the lysosomal degradation of non-activated internalized NOTCH1. Monoubiquitination at Lys-1749 is required for activation by gamma-secretase cleavage, it promotes interaction with AAK1, which stabilizes it. Deubiquitination by EIF3F is necessary for nuclear import of activated Notch.

10116:Defb18
gene id: 10116:Defb18
uniprot id: Q32ZH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

10116:Or5p78
gene id: 10116:Or5p78
uniprot id: A0A0G2K6G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Arnt
gene id: 10116:Arnt
uniprot id: P41739
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Monomer. Homodimer only upon binding to a DNA (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Interacts with TACC3 (By similarity). Interacts with HIF1A, EPAS1, NPAS1 and NPAS3; forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Forms a heterodimer with AHRR, as well as with other bHLH proteins. Interacts with NOCA7 (By similarity). Interacts with TACC3 (By similarity). Interacts with AHR; the heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity). Interacts with SIM1 and NPAS4 (By similarity).
messages: Nucleus
messages: Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity).

10116:LOC685171
gene id: 10116:LOC685171
uniprot id: A6IE44
uniprot id: D3ZK65
names: Subcellular Location Annotation
messages: Melanosome

10116:Sim2
gene id: 10116:Sim2
uniprot id: A6KPY2
uniprot id: D4AA36
names: Subcellular Location Annotation
messages: Nucleus

10116:Jund
gene id: 10116:Jund
uniprot id: A0A8L2QFM6
uniprot id: P52909
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. Jun subfamily.
messages: Binds DNA via bZIP domain; DNA-binding is under control of cellular redox homeostasis (in vitro) (By similarity). To enable DNA binding, the bZIP domain must undergo a conformational rearrangement which requires the reduction of the interchain disulfide bond between FosB and JunD (in vitro) (By similarity).
messages: Heterodimer; binds DNA as a heterodimer (By similarity). Component of an AP-1 transcription factor complex composed of JUN-FOS heterodimers (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with FOS proteins, thereby binding to the AP-1 consensus sequence and stimulating transcription (By similarity). Forms heterodimers with FOSB; thereby binding to the AP-1 consensus sequence (By similarity). Interacts (via MBM motif) with MEN1; this interaction represses transcriptional activation (By similarity). Interacts with MAPK10; this interaction is inhibited in the presence of MEN1 (By similarity).
messages: Nucleus
messages: Phosphorylated by MAP kinases MAPK8 and MAPK10; phosphorylation is inhibited in the presence of MEN1.
messages: Transcription factor binding AP-1 sites (By similarity). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (By similarity).

10116:Rad23a
gene id: 10116:Rad23a
uniprot id: Q5XFX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

10116:Pgam5
gene id: 10116:Pgam5
uniprot id: Q562B5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Dimer. Forms a ternary complex with NFE2L2 and KEAP1. Interacts with BCL2L1 and MAP3K5 (By similarity). Upon TNF-induced necrosis, forms in complex with RIPK1, RIPK3 and MLKL; the formation of this complex leads to PGAM5 phosphorylation (By similarity). Interacts with DNM1L; this interaction leads to DNM1L dephosphorylation and activation and eventually to mitochondria fragmentation (By similarity).
messages: Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression (By similarity). Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane
messages: Phosphorylated by the RIPK1/RIPK3 complex under necrotic conditions. This phosphorylation increases PGAM5 phosphatase activity (By similarity).
messages: Proteolytically cleaved by PARL in response to loss of mitochondrial membrane potential.
messages: The N-terminal 35 amino acids, including the potential transmembrane alpha-helix, function as a non-cleaved mitochondrial targeting sequence that targets the protein to the cytosolic side of the outer mitochondrial membrane.

10116:Ldhb
gene id: 10116:Ldhb
uniprot id: A6IMU4
uniprot id: P42123
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer. Interacts with PTEN upstream reading frame protein MP31; the interaction leads to inhibition of mitochondrial lactate dehydrogenase activity, preventing conversion of lactate to pyruvate in mitochondria.
messages: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
messages: Mitochondrion inner membrane

10116:Fgf23
gene id: 10116:Fgf23
uniprot id: A6ILX1
uniprot id: Q8VI82
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the heparin-binding growth factors family.
messages: Expressed in the parathyroid.
messages: Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases (By similarity).
messages: Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).
messages: O-glycosylated at Thr-171 and Thr-178 by GALNT3 and glycosylation of Thr-178 requires previous glycosylation at Thr171. Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23 (By similarity).
messages: Phosphorylation at Ser-180 mediated by FAM20C slows down glycosylation at Thr-178 notably.
messages: Regulator of phosphate homeostasis (By similarity). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity). Regulator of vitamin-D metabolism (By similarity). Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity). Acts directly on the parathyroid to decrease PTH secretion (PubMed:17992255). Up-regulates EGR1 expression in the presence of KL (PubMed:17086194).
messages: Secreted

10116:Olr1082
gene id: 10116:Olr1082
uniprot id: P23268
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Odorant receptor.
messages: Olfactory epithelium.

10116:Or2h15
gene id: 10116:Or2h15
uniprot id: D3ZKK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ccnt2
gene id: 10116:Ccnt2
uniprot id: A6IBW0
uniprot id: A9CMA7
uniprot id: D3ZGL6
names: Similarity
messages: Belongs to the cyclin family.

10116:Snca
gene id: 10116:Snca
uniprot id: A6KF04
uniprot id: A6KF07
uniprot id: P37377
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.
messages: Belongs to the synuclein family.
messages: Cytoplasm
messages: Found only in brain (hippocampus, brainstem and cortex). Specifically expressed in neuronal cell bodies and synapses.
messages: Membrane
messages: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).
messages: Nucleus
messages: Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress.
messages: Secreted
messages: Soluble monomer. Homotetramer. A dynamic intracellular population of tetramers and monomers coexists normally and the tetramer plays an essential role in maintaining homeostasis (By similarity). Interacts with UCHL1 (PubMed:12408865). Interacts with phospholipase D and histones. Interacts (via N-terminus) with synphilin-1/SNCAIP; this interaction promotes formation of SNCA inclusions in the cytoplasm. Interacts with CALM1. Interacts with STXBP1; this interaction controls SNCA self-replicating aggregation. Interacts with SNARE components VAMP2 and SNAP25; these interactions allows SNARE complex assembly and integrity (By similarity). Interacts with RPH3A and RAB3A (By similarity). Interacts with SERF1A; this interaction promotes the aggregation of SNCA (By similarity). Interacts with SEPTIN4 (By similarity).
messages: Synapse
messages: Ubiquitinated. The predominant conjugate is the diubiquitinated form.
messages: axon

10116:Adgre4
gene id: 10116:Adgre4
uniprot id: Q5Y4N7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Gucy2g
gene id: 10116:Gucy2g
uniprot id: A6JHY5
uniprot id: F1MA14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

10116:Ihh
gene id: 10116:Ihh
uniprot id: A6JVX0
uniprot id: F1LP42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

10116:Ube2b
gene id: 10116:Ube2b
uniprot id: A6HE84
uniprot id: A6HE85
uniprot id: P63149
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation (By similarity). In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Cell membrane
messages: Expressed at high levels in testes, moderate levels in muscle, heart, and brain, and low levels in liver and kidney. Upon fasting, increased levels were seen in muscle, heart, liver, and kidney.
messages: Interacts with RAD18, UBR2 and WAC.
messages: Nucleus
messages: Up-regulated by NGF.

10116:Unc5d
gene id: 10116:Unc5d
uniprot id: A0A0G2KA37
uniprot id: F1LW30
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Interacts (via extracellular domain) with FLRT2 and FLRT3 (via extracellular domain); the interaction is direct. Has higher affinity for FLRT2 (PubMed:25374360). Identified in a complex with FLRT3 and ADGRL3; does not interact with ADGRL3 by itself (By similarity).
messages: Membrane
messages: Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis (By similarity).
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.
messages: Receptor for the netrin NTN4 that promotes neuronal cell survival. Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).

10116:Bloc1s5
gene id: 10116:Bloc1s5
uniprot id: B2GV52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BLOC1S5 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking (By similarity).
messages: Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos. Interacts with BLOC1S4, BLOC1S6, DTNBP1/BLOC1S7 and PI4K2A (By similarity). Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8.

10116:Gimap8
gene id: 10116:Gimap8
uniprot id: A0A0H2UHZ9
uniprot id: Q4KLG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
messages: Endoplasmic reticulum
messages: Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.
messages: Golgi apparatus
messages: Mitochondrion
messages: Spleen, thymus and T-cells. Greatly reduced in T-cells from lymphopenic rats.
messages: cytosol

10116:Ncmap
gene id: 10116:Ncmap
uniprot id: F1M2Z5
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in the peripheral nervous system Schwann cells (at protein level).
messages: Glycosylated.
messages: Plays a role in myelin formation.
messages: Up-regulated in Schwann cells by EGR2 during nerve development and after nerve injury.

10116:Tarbp2
gene id: 10116:Tarbp2
uniprot id: Q3SWU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity). Binds in vitro to the PRM1 3'-UTR (By similarity). Seems to act as a repressor of translation (By similarity). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1 (By similarity). Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation (By similarity).
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC) (By similarity). Interacts with IRF7; this interaction prevents IRF7 phosphorylation and activation (By similarity).
messages: perinuclear region

10116:Clec4d
gene id: 10116:Clec4d
uniprot id: Q69FH1
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM) (By similarity). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (PubMed:23921530). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. The heterodimer formed with CLEC6A is active against fungal infection. Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (By similarity).
messages: Cell membrane
messages: Expressed in myeloid cells (dendritic cells, macrophages and neutrophils) and B-cells.
messages: Heterodimer with CLEC4E; disulfide-linked (PubMed:23921530). CLEC4E acts as a bridge for interaction between CLEC4D and FCER1G to form a functional complex (PubMed:23921530). Heterodimer with CLEC6A; this heterodimer forms a pattern recognition receptor (PRR) against fungal infection (By similarity).

10116:Eva1b
gene id: 10116:Eva1b
uniprot id: B2RZB3
names: Similarity
messages: Belongs to the EVA1 family.

10116:Zfhx4
gene id: 10116:Zfhx4
uniprot id: D4A3U5
names: Subcellular Location Annotation
messages: Nucleus

10116:Or4c108b
gene id: 10116:Or4c108b
uniprot id: A6HN24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Or5k16
gene id: 10116:Or5k16
uniprot id: M0R9V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Reep2
gene id: 10116:Reep2
uniprot id: Q0VGJ9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:RGD1308751
gene id: 10116:RGD1308751
uniprot id: A6KAF5
uniprot id: D3ZKC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

10116:Mitf
gene id: 10116:Mitf
uniprot id: A0A0G2K5U8
uniprot id: O88368
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MiT/TFE family.
messages: Cytoplasm
messages: Homodimer or heterodimer; dimerization is mediated via the coiled coil region (By similarity). Efficient DNA binding requires dimerization with another bHLH protein (By similarity). Binds DNA in the form of homodimer or heterodimer with either TFE3, TFEB or TFEC (By similarity). Identified in a complex with HINT1 and CTNNB1 (By similarity). Interacts with KARS1 (By similarity). Interacts with VSX2 (By similarity).
messages: Nucleus
messages: Osteopetrotic rat of unknown genetic defect microphthalmia-blanc (mib) has been described whose skeletal sclerosis improves dramatically with age and that is associated with pigmentation defects. Mib at the homozygous state shows absence of skin and fur pigmentation, small eyes, and defects of incisor tooth eruption.
messages: Phosphorylation at Ser-405 significantly enhances the ability to bind the tyrosinase promoter (By similarity). Phosphorylated at Ser-180 and Ser-516 following KIT signaling, triggering a short live activation: Phosphorylation at Ser-180 and Ser-516 by MAPK and RPS6KA1, respectively, activate the transcription factor activity but also promote ubiquitination and subsequent degradation by the proteasome (By similarity). Phosphorylated in response to blue light (415nm) (By similarity).
messages: The leucine zipper region is part of a larger coiled coil.
messages: Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
messages: Ubiquitinated following phosphorylation at Ser-180, leading to subsequent degradation by the proteasome. Deubiquitinated by USP13, preventing its degradation.

10116:Ece1
gene id: 10116:Ece1
uniprot id: A0A0G2K465
uniprot id: A0A8I6AJE5
uniprot id: A0A8I6AL15
uniprot id: A6ITF1
names: Subcellular Location Annotation
messages: Membrane

10116:Zfp397
gene id: 10116:Zfp397
uniprot id: M0R6E4
names: Subcellular Location Annotation
messages: Nucleus

10116:Gstm5
gene id: 10116:Gstm5
uniprot id: A6HUV7
uniprot id: Q9Z1B2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the GST superfamily. Mu family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Expressed in testis and brain. Very low expression in liver, kidney, heart and lung.
messages: Homodimer.
messages: The N-terminus is blocked.

10116:Zkscan8
gene id: 10116:Zkscan8
uniprot id: A6KN85
uniprot id: D4A3X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

10116:Srek1
gene id: 10116:Srek1
uniprot id: Q9JKL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the splicing factor SR family.
messages: Interacts with SREK1IP1 (By similarity). Homodimer. Binds SFRS1, SFRS2, SFRS3 and SFRS6. Interacts with the spliceosome.
messages: Nucleus
messages: Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3.
messages: Ubiquitous. Detected in liver, brain, lung, spleen, testis and pancreas.

10116:Mtfmt
gene id: 10116:Mtfmt
uniprot id: A6J5F4
uniprot id: Q5I0C5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Fmt family.
messages: Composed of an N- and a C-terminal domain. The N-terminal domain carries the tetrahydrofolate (THF)-binding site and the C-terminal domain is presumably involved in positioning the Met-tRNA substrate for the formylation reaction.
messages: Methionyl-tRNA formyltransferase that formylates methionyl-tRNA in mitochondria and is crucial for translation initiation.
messages: Mitochondrion

10116:Slc12a3
gene id: 10116:Slc12a3
uniprot id: A6JY68
uniprot id: G3V8G0
uniprot id: P55018
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules (PubMed:10894798, PubMed:8021284, PubMed:16887815). Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1 (By similarity).
messages: Expressed in kidney, predominantly in the outer cortex in short tubule segments.
messages: Homodimer. Interacts with KLHL3 (By similarity). Interacts with IL18R1; this interaction is increased by IL18 treatment (By similarity).
messages: Interaction between the cytoplasmic N-terminal and C-terminal domains (NTD and CTD, respectively) is essential for SLC12A3/NCC transporter activity. Phosphorylation by OXSR1/OSR1 and STK39/SPAK may activate SLC12A3/NCC by facilitating this interaction.
messages: Membrane
messages: Phosphorylated at Thr-53, Thr-58 and Ser-71 by OXSR1/OSR1 and STK39/SPAK downstream of WNK4, promoting its activity (PubMed:16887815). Phosphorylated in response to IL18 (By similarity).
messages: Phosphorylation by OXSR1/OSR1 and STK39/SPAK in kidney distal convoluted tubules downstream of WNK4 promotes its activity (PubMed:16887815). Also activated by OXSR1/OSR1 and STK39/SPAK downstream of WNK3 (By similarity). Activated by isotonic conditions (PubMed:10894798). Inhibited by thiazide-type diuretics including polythiazide, metolazone, bendroflumethiazide, trichloromethiazide, hydrochlorothiazide and chlorthalidone (PubMed:10894798). Thiazide drugs specifically inhibit SLC12A3/NCC transporter activity by competing with chloride for binding (By similarity).
messages: Ubiquitinated; ubiquitination is essential for regulation of endocytosis.

10116:Napa
gene id: 10116:Napa
uniprot id: A6J895
uniprot id: P54921
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP family.
messages: Cell membrane
messages: Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2 (PubMed:11931741). Found in a complex with VAMP8 (PubMed:9614193). Component of a SNARE-like complex that contains at least ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha (By similarity). Interacts with VTI1A (By similarity). Interacts with STX12 (PubMed:9507000). Interacts with GNA12 (via N-terminus); the interaction promotes CDH5 localization to plasma membrane (By similarity).
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Together with GNA12 promotes CDH5 localization to plasma membrane.

10116:Arl2bp
gene id: 10116:Arl2bp
uniprot id: A6JY54
uniprot id: Q4V8C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Interacts with GTP bound ARL2 and ARL3; the complex ARL2-ARL2BP as well as ARL2BP alone, binds to SLC25A4/ANT1. Interaction with ARL2 may be required for cilia basal body localization (By similarity). Interacts with STAT3; interaction is enhanced with ARL2. Found in a complex with ARL2BP, ARL2 and SLC25A6. Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with STAT2, STAT3 and STAT4.
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity).
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
messages: Ubiquitous with higher expression in brain, especially in hippocampus and cortex. Also expressed in lung, cerebellum, liver, kidney, spleen and heart (at protein level).
messages: centrosome
messages: cilium basal body
messages: spindle

10116:Cdhr1
gene id: 10116:Cdhr1
uniprot id: Q91XU7
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in the retina. Strongly expressed by the mitral and tufted cells in the main and accessory olfactory bulbs. Also expressed in the septum and olfactory cortex. Weakly expressed in the triangular septal nucleus and piriform cortex.
messages: Interacts with PROM1.
messages: Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity).
messages: Undergoes proteolytic cleavage; produces a soluble 95 kDa N-terminal fragment and a 25 kDa cell-associated C-terminal fragment.

10116:Angptl4
gene id: 10116:Angptl4
uniprot id: Q6TMA8
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cleaved into a smaller N-terminal chain and a larger chain that contains the fibrinogen C-terminal domain; both cleaved and uncleaved forms are detected in the extracellular space. The cleaved form is not present within the cell.
messages: Forms disulfide-linked dimers and tetramers.
messages: Homooligomer; disulfide-linked via Cys residues in the N-terminal part of the protein. The homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer (PubMed:14570927). The homooligomer unprocessed form is able to interact with the extracellular matrix (By similarity).
messages: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (By similarity). Depending on context, may modulate tumor-related angiogenesis (By similarity).
messages: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. Has higher activity in LPL inactivation than the uncleaved protein.
messages: N-glycosylated.
messages: Secreted
messages: extracellular matrix

10116:Dtwd1
gene id: 10116:Dtwd1
uniprot id: Q6AYF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDD superfamily. DTWD1 family.
messages: Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)).
messages: Nucleus

10116:Entpd1
gene id: 10116:Entpd1
uniprot id: A6JH62
uniprot id: F1M0G3
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

10116:Plvap
gene id: 10116:Plvap
uniprot id: Q9WV78
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development.
messages: Expressed in endothelial cells of the lung at 12 dpc.
messages: Expressed in lung (alveolar endothelial and bronchial epithelial cells), kidney (endothelium of peritubular capillaries), spleen, liver, adrenal (endothelial cells of the zona reticularis of the cortex and chromaffin cells in the medulla), pancreas (islets of Langerhans), testis (germ cells, interstitial cells in neonatal testis and spermatids), ovary (stromal endothelial, thecal layer of developing follicles, luteal cells within the corpus luteum), intestine (endothelium of capillaries of the intestinal villi) and pituitary (pituicyte cells in the neural lobe) (at protein level). Expressed in lung, kidney, spleen, liver, adrenal, testis, heart, muscle, pituitary, thyroid and ovary.
messages: Homodimer.
messages: caveola
messages: perinuclear region

10116:Arl8a
gene id: 10116:Arl8a
uniprot id: A6ICE2
uniprot id: D3ZPP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: axon
messages: spindle

10116:Ckmt2
gene id: 10116:Ckmt2
uniprot id: B0BNC0
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

10116:Bms1
gene id: 10116:Bms1
uniprot id: A0A096MJ94
names: Subcellular Location Annotation
messages: nucleolus

10116:Prag1
gene id: 10116:Prag1
uniprot id: D3ZMK9
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily.
messages: Catalytically inactive protein kinase that acts as a scaffold protein (PubMed:29503074). Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (PubMed:16481321). Promotes Src family kinase (SFK) signallig by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (PubMed:27116701, PubMed:21873224). Acts as a critical coactivator of Notch signaling (By similarity).
messages: Cytoplasm
messages: Despite of the presence of a putative ATP-binding motif, this protein does not bind ATP, suggesting that it has no protein kinase activity (PubMed:29503074).
messages: Highly-expressed in brain, including cortical and hippocampal pyramidal neurons, as well as in kidney, spleen, colon and small intestine (PubMed:16481321).
messages: Homodimer (PubMed:29503074). Dimerization leads to the catalytic activation of CSK (PubMed:29503074). Interacts (via C-terminus) with RND2 (PubMed:16481321). Interacts with CSK (via SH2 domain) in a Tyr-391 phosphorylation-dependent manner; this interaction potentiates kinase activity of CSK (PubMed:29503074, PubMed:21873224, PubMed:27116701). Interacts with NOTCH1 intracellular domain (N1ICD) (By similarity). Forms a complex with N1ICD and MAML1, in a MAML1-dependent manner (By similarity).
messages: Nucleus
messages: Phosphorylated by CSK on Tyr-238, Tyr-343, and Tyr-391; Tyr-391 is a primary site of phosphorylation.
messages: The dimerization region encompasses helices both from the N- and C-terminal of the protein kinase domain.
messages: focal adhesion

10116:Cdk5rap1
gene id: 10116:Cdk5rap1
uniprot id: A6KHY4
uniprot id: Q9JLH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Expressed in brain.
messages: Interacts with CDK5R1 (p35 form) (PubMed:10721722). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1 (By similarity). Forms a complex with CDK5R1 and CDK5 (By similarity).
messages: Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (By similarity). Essential for efficient and highly accurate protein translation by the ribosome (By similarity). Specifically inhibits CDK5 activation by CDK5R1 (By similarity). Essential for efficient mitochondrial protein synthesis and respiratory chain (By similarity).
messages: Mitochondrion inner membrane

10116:Rgmb
gene id: 10116:Rgmb
uniprot id: M0RB24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

10116:Osr1
gene id: 10116:Osr1
uniprot id: B0K011
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Odd C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.

10116:Psmd8
gene id: 10116:Psmd8
uniprot id: F1LMQ3
uniprot id: Q3B8P5
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

10116:Nectin3
gene id: 10116:Nectin3
uniprot id: A6IQW6
names: Similarity
messages: Belongs to the nectin family.

10116:Srd5a3
gene id: 10116:Srd5a3
uniprot id: A0A140TAI0
uniprot id: Q5RJM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Expressed in the 2 tissues tested i.e. testis and liver.
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol (PubMed:8486680). Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation (PubMed:8486680). Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (PubMed:8486680). Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (By similarity).
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

10116:Timm10
gene id: 10116:Timm10
uniprot id: A6HMR8
uniprot id: P62074
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9, TIMM10/TIM10A and FXC1/TIM10B (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

10116:Mapk7
gene id: 10116:Mapk7
uniprot id: E9PTH2
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm

10116:Cnbp
gene id: 10116:Cnbp
uniprot id: P62634
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Arginine methylation by PRMT1 in the Arg/Gly-rich region impedes RNA binding.
messages: Associates with the 40S ribosomal subunit, the 80S ribosome and with polysomes.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus
messages: Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (By similarity). Has a role as transactivator of the Myc promoter (By similarity). Binds single-stranded RNA in a sequence-specific manner (PubMed:7788528). Binds G-rich elements in target mRNA coding sequences (By similarity). Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (By similarity).

10116:Coa8
gene id: 10116:Coa8
uniprot id: A6KBS9
uniprot id: Q32Q90
names: Caution
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COA8 family.
messages: First thought to play a role in the regulation of apoptosis, mediating mitochondria-induced cell death in vascular smooth muscle cells through the release of cytochrome c (COX) from mitochondria and the activation of the caspase cascade. However, recent studies show that it is not directly involved in apoptosis regulation but in the protection of COX from oxidatively induced degradation.
messages: In conditions of increased oxidative stress, the protein is stabilized, increasing its mature intramitochondrial form and thereby protecting COX from oxidatively induced degradation.
messages: In normal conditions, the cytoplasmic precursor protein is rapidly degraded by the ubiquitination-proteasome system (UPS). Oxidative stress induces protein stabilization and import into mitochondria where it protects COX from degradation.
messages: Mitochondrion inner membrane
messages: N-terminal mitochondrial targeting sequence is cleaved from the mature protein once in the mitochondrion.
messages: Required for cytochrome c complex (COX) IV assembly and function Protects COX assembly from oxidation-induced degradation, COX being the terminal component of the mitochondrial respiratory chain.

10116:Nat8f1
gene id: 10116:Nat8f1
uniprot id: Q9QXT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the camello family.
messages: May play a role in regulation of gastrulation.
messages: Membrane

10116:Gar1
gene id: 10116:Gar1
uniprot id: A6HVQ1
uniprot id: Q6AYA1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Cajal body
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Interaction with SMN1 requires at least one of the RGG-box regions.
messages: Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which contains NHP2/NOLA2, GAR1/NOLA1, NOP10/NOLA3, and DKC1/NOLA4, which is presumed to be the catalytic subunit. The complex contains a stable core formed by binding of one or two NOP10-DKC1 heterodimers to NHP2; GAR1 subsequently binds to this core via DKC1. The complex binds a box H/ACA small nucleolar RNA (snoRNA), which may target the specific site of modification within the RNA substrate. The complex also interacts with TERC, which contains a 3'-terminal domain related to the box H/ACA snoRNAs. Specific interactions with snoRNAs or TERC are mediated by GAR1 and NHP2. Associates with NOLC1/NOPP140. H/ACA snoRNPs interact with the SMN complex, consisting of SMN1 or SMN2, GEMIN2/SIP1, DDX20/GEMIN3, and GEMIN4. This is mediated by interaction between GAR1 and SMN1 or SMN2. The SMN complex may be required for correct assembly of the H/ACA snoRNP complex. Component of the telomerase holoenzyme complex composed of one molecule of TERT, one molecule of WRAP53/TCAB1, two molecules of H/ACA ribonucleoprotein complex subunits DKC1, NOP10, NHP2 and GAR1, and a telomerase RNA template component (TERC). The telomerase holoenzyme complex is associated with TEP1, SMG6/EST1A and POT1.
messages: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

10116:Prdm4
gene id: 10116:Prdm4
uniprot id: A6IFD2
uniprot id: F1LPR7
uniprot id: Q9QZP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: May function as a transcription factor involved in cell differentiation.
messages: Nucleus

10116:Ldlr
gene id: 10116:Ldlr
uniprot id: P35952
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
messages: Cell membrane
messages: Early endosome
messages: Golgi apparatus
messages: Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (By similarity). Interacts (via NPXY motif) with LDLRAP1 (via PID domain). Interacts with ARRB1. Interacts with SNX17. Interacts with the full-length immature form of PCSK9 (via C-terminus) (By similarity).
messages: Late endosome
messages: Lysosome
messages: N- and O-glycosylated.
messages: The NPXY motif mediates the interaction with the clathrin adapter DAB2 and with LDLRAP1 which are involved in receptor internalization. A few residues outside the motif also play a role in the interaction.
messages: Ubiquitinated by MYLIP leading to degradation.
messages: clathrin-coated pit

10116:Mknk1
gene id: 10116:Mknk1
uniprot id: A0A0G2K3K7
uniprot id: A6JZ51
uniprot id: Q4G050
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Dual phosphorylation of Thr-197 and Thr-202 activates the kinase. Phosphorylation of Thr-332 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1 (By similarity).
messages: Interacts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2, and to the p38 kinases (By similarity).
messages: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap (By similarity).
messages: Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway.

10116:Rbm17
gene id: 10116:Rbm17
uniprot id: Q6AY02
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the spliceosome.
messages: Nucleus
messages: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

10116:Gbx2
gene id: 10116:Gbx2
uniprot id: A6JQK7
uniprot id: G3V8J6
names: Subcellular Location Annotation
messages: Nucleus

10116:Pde6h
gene id: 10116:Pde6h
uniprot id: A6IMK0
uniprot id: P61250
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones (By similarity).
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
messages: Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).
messages: The C-terminal region is important in conferring inhibition.

10116:Slc39a9
gene id: 10116:Slc39a9
uniprot id: A0A0G2KAR8
uniprot id: A6JDJ3
uniprot id: Q3KR82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion
messages: Nucleus
messages: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.
messages: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Regulates intracellular zinc level, resulting in the enhancement of AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to the BCR activation (By similarity). Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1 (PubMed:27164415, PubMed:35625396). This pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells (PubMed:27164415, PubMed:35625396). Mediates androgen-induced vascular endothelial cell proliferation through activation of an inhibitory G protein leading to the AKT1 and MAPK3/MAPK1 (Erk1/2) activation which in turn modulate inhibition (phosphorylation) of GSK3B and CCND1 transcription. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process (By similarity).
messages: perinuclear region
messages: trans-Golgi network membrane

10116:Snx13
gene id: 10116:Snx13
uniprot id: A0A8I6GI34
uniprot id: A6HB95
uniprot id: D3ZCH3
names: Similarity
messages: Belongs to the sorting nexin family.

10116:Mrpl53
gene id: 10116:Mrpl53
uniprot id: B2RYW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

10116:Tmem41a
gene id: 10116:Tmem41a
uniprot id: A0A9K3Y6N6
uniprot id: B1WC43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

10116:Vom2r9
gene id: 10116:Vom2r9
uniprot id: D3ZJ30
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Nts
gene id: 10116:Nts
uniprot id: A6IGA8
uniprot id: G3V6J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

10116:Cpvl
gene id: 10116:Cpvl
uniprot id: Q4QR71
names: Function
names: Similarity
messages: Belongs to the peptidase S10 family.
messages: May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

10116:Or1l4b
gene id: 10116:Or1l4b
uniprot id: D3ZIV0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Afm
gene id: 10116:Afm
uniprot id: P36953
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ALB/AFP/VDB family.
messages: Forms a 1:1 complex with Wnt family members; interacts with WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B.
messages: Functions as carrier for hydrophobic molecules in body fluids. Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B. Binds vitamin E. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the transport of vitamin E across the blood-brain barrier.
messages: N-glycosylated; more than 90% of the glycans are sialylated.
messages: Secreted
messages: The second albumin domain forms a deep binding pocket that contains palmitoleic acid (in vitro). Palmitoleic acid is most likely not the physiological ligand. Instead, this pocket may accomodate the covalently bound lipid moiety of Wnt family members.

10116:Cetn4
gene id: 10116:Cetn4
uniprot id: A0A8I5ZYD1
names: Similarity
messages: Belongs to the centrin family.

10116:Unc5b
gene id: 10116:Unc5b
uniprot id: A0A8I6A411
uniprot id: O08722
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Interacts with the cytoplasmic part of DCC (PubMed:10399920). Interacts with GNAI2 via its cytoplasmic part (By similarity). Interacts (via death domain) with DAPK1 (via death domain) (PubMed:15729359, PubMed:18582460). Interacts (via extracellular domain) with FLRT3 (via extracellular domain); the interaction is direct. Interacts (via extracellular domain) with FLRT2 and FLRT3 (via extracellular domain), but has higher affinity for FLRT3. Identified in a complex with FLRT3 and ADGRL3; does not interact with ADGRL3 by itself (By similarity).
messages: Mainly expressed in regions of differentiating neurons. Expressed in the developing sensory ganglia that flank the spinal cord from E12, peaking at E14. Expressed in the roof plate region of the spinal cord from E14.
messages: Membrane
messages: Membrane raft
messages: Palmitoylation is required for pro-apoptotic activity, but not for location at lipid rafts.
messages: Phosphorylated on cytoplasmic tyrosine residues.
messages: Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (PubMed:10399920, PubMed:9126742). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:11387206). Mediates apoptosis by activating DAPK1 (PubMed:18582460). In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (PubMed:15729359).

10116:Nid2
gene id: 10116:Nid2
uniprot id: B5DFC9
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell adhesion glycoprotein. Might be involved in osteoblast differentiation. It probably has a role in cell-extracellular matrix interactions (By similarity).
messages: Highly N- and O-glycosylated.
messages: Interacts with LAMA2. Interacts with COL13A1 (By similarity). Interacts with EFEMP2 (By similarity).
messages: basement membrane

10116:Tlr5
gene id: 10116:Tlr5
uniprot id: A6JGM7
uniprot id: G3V6F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

10116:Slc22a22
gene id: 10116:Slc22a22
uniprot id: F7F331
uniprot id: Q66H77
names: Subcellular Location Annotation
messages: Membrane

10116:Ap1m2
gene id: 10116:Ap1m2
uniprot id: B2RZA4
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

10116:RT1-CE15
gene id: 10116:RT1-CE15
uniprot id: Q6MG29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Involved in the presentation of foreign antigens to the immune system.
messages: Membrane

10116:Ccne2
gene id: 10116:Ccne2
uniprot id: A0A8I6A291
uniprot id: A6JFS7
uniprot id: D3ZQ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family.
messages: Nucleus

10116:Trhr
gene id: 10116:Trhr
uniprot id: Q01717
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

10116:Mrgprx2l
gene id: 10116:Mrgprx2l
uniprot id: Q7TN47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

10116:Or2t35
gene id: 10116:Or2t35
uniprot id: A0A8I6A1I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Osbpl6
gene id: 10116:Osbpl6
uniprot id: A0A0G2JZR1
uniprot id: A0A8I6AMZ3
uniprot id: A6HMH5
uniprot id: D4A0F3
names: Similarity
messages: Belongs to the OSBP family.

10116:Triqk
gene id: 10116:Triqk
uniprot id: A6II86
uniprot id: Q5EB66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIQK family.
messages: Endoplasmic reticulum membrane
messages: May play a role in cell growth and maintenance of cell morphology.
messages: Membrane

10116:Tspo
gene id: 10116:Tspo
uniprot id: A6HTA0
uniprot id: P16257
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TspO/BZRP family.
messages: Highly expressed in adrenal gland.
messages: Interacts with TSPOAP1. Interacts with MOST-1. May interact with STAR.
messages: Membrane
messages: Mitochondrion membrane
messages: Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis (By similarity). Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:2555358).
messages: The N-terminus is blocked.

10116:Dusp26
gene id: 10116:Dusp26
uniprot id: A6IVW2
uniprot id: Q5FVI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Cytoplasm
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.
messages: Golgi apparatus
messages: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity.
messages: Interacts with HSF4.
messages: Nucleus

10116:Lgals5
gene id: 10116:Lgals5
uniprot id: P47967
names: Function
names: Subunit
names: Tissue Specificity
messages: Erythrocytes.
messages: May function in erythrocyte differentiation.
messages: Monomer.

10116:Apobec4
gene id: 10116:Apobec4
uniprot id: Q6AXX9
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Putative C to U editing enzyme whose physiological substrate is not yet known.

10116:Duox2
gene id: 10116:Duox2
uniprot id: Q9ES45
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: By forskolin, thyrotropin and insulin. Down-regulated by the antithyroid drug methimazole.
messages: Cell junction
messages: Expressed in colon, duodenum, rectum and thyroid.
messages: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
messages: Heterodimer with DUOXA2; disulfide-linked. Interacts with TXNDC11, TPO and CYBA.
messages: In the N-terminal section; belongs to the peroxidase family.
messages: N-glycosylated.
messages: The NADPH oxidase activity is calcium-dependent. Peroxidase activity is inhibited by aminobenzohydrazide (By similarity).
messages: There is no evidence for the expression of the corresponding protein in vitro.

10116:Ppp3r2
gene id: 10116:Ppp3r2
uniprot id: A6KJD5
uniprot id: P28470
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calcineurin regulatory subunit family.
messages: Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit (also known as calcineurin B). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2) (By similarity). Interacts with SPATA33 (via PQIIIT motif) (By similarity).
messages: Mitochondrion
messages: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
messages: Testis specific.
messages: This protein has four functional calcium-binding sites.

10116:Kcna6
gene id: 10116:Kcna6
uniprot id: A6ILW1
uniprot id: G3V8L6
names: Subcellular Location Annotation
messages: Membrane

10116:Sfxn5
gene id: 10116:Sfxn5
uniprot id: A6IAR4
uniprot id: Q8CFD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrial amino-acid transporter (By similarity). Transports citrate (PubMed:12150972). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (By similarity) (PubMed:12150972). In brown adipose tissue, plays a role in the regulation of UCP1-dependent thermogenesis probably by supporting mitochondrial glycerol-3-phosphate utilization (By similarity).
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Specifically expressed in the brain.

10116:Pmepa1
gene id: 10116:Pmepa1
uniprot id: A6KL01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

10116:Mark2
gene id: 10116:Mark2
uniprot id: A0A0G2K6X6
uniprot id: A0A8I5Y7M0
uniprot id: A0A8I6GJH6
uniprot id: O08679
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-208 by TAOK1 activates the kinase activity, leading to phosphorylation and detachment of MAPT/TAU from microtubules. Phosphorylation at Ser-212 by GSK3-beta (GSK3B) inhibits the kinase activity. Phosphorylation by CaMK1 promotes activity and is required to promote neurite outgrowth. Phosphorylation at Thr-539 by PRKCZ/aPKC in polarized epithelial cells inhibits the kinase activity and promotes binding to 14-3-3 protein YWHAZ, leading to relocation from cell membrane to cytoplasm.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer (PubMed:16472737). Interacts (when phosphorylated at Thr-539) with YWHAZ (By similarity). Interacts with MTCL1; the interaction is direct and increases MARK2 microtubule-binding ability (By similarity). Interacts with PAK5; leading to inhibit the protein kinase activity (PubMed:16014608). Interacts with MAPT/TAU (By similarity). Interacts with YWHAB, YWHAG and YWHAQ (By similarity).
messages: Inhibited by hymenialdisine (By similarity). Activated by phosphorylation on Thr-208 by STK11/LKB1 and TAOK1. Inhibited by phosphorylation at Ser-212 or Thr-539. Inhibited by PAK5; inhibition is independent of the kinase activity of PAK5.
messages: Lateral cell membrane
messages: Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.
messages: The KA1 domain mediates binding to phospholipids and targeting to membranes.
messages: The UBA domain does not seem to bind ubiquitin and ubiquitin-like and might play a role in regulating the enzyme conformation and localization. Activation of the kinase activity following phosphorylation at Thr-208 is accompanied by a conformational change that alters the orientation of the UBA domain with respect to the catalytic domain (By similarity).
messages: cytoskeleton
messages: dendrite

10116:Agfg1
gene id: 10116:Agfg1
uniprot id: Q4KLH5
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Contains FG repeats.
messages: Cytoplasmic vesicle
messages: Interacts with EPS15R and EPS15. Interacts with FCHO1 (By similarity).
messages: Nucleus
messages: O-glycosylated.
messages: Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization (By similarity).

10116:Ptcd2
gene id: 10116:Ptcd2
uniprot id: A0A8I5ZPV5
uniprot id: A6I558
uniprot id: D4A9I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTCD2 family.
messages: Mitochondrion

10116:Borcs5
gene id: 10116:Borcs5
uniprot id: B1H257
uniprot id: F7EXS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

10116:Zfyve9
gene id: 10116:Zfyve9
uniprot id: A6JYW0
uniprot id: D3ZDC7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

10116:Lamp5
gene id: 10116:Lamp5
uniprot id: Q5PPI4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Endosome membrane
messages: Glycosylated.
messages: Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.
messages: Recycling endosome
messages: dendrite
messages: growth cone membrane
messages: synaptic vesicle membrane

10116:Igfbp6
gene id: 10116:Igfbp6
uniprot id: A6KCS9
uniprot id: P35572
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration.
messages: Interacts (via C-terminal domain) with PHB2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: O-glycosylated.
messages: Secreted

10116:Lhx1
gene id: 10116:Lhx1
uniprot id: A6HHL1
uniprot id: P63007
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in epithelial structures of the embryonic metanephric kidneys including the ureteric bud and its derivatives, and coma-shaped and S-shaped bodies differentiating from the metanephric mesenchyme. In the adult brain, expressed in the adrenal medulla, Purkinje cells of the cerebellum, hypothalamus, midbrain and pons. Also expressed in the adult testis.
messages: Interacts with LDB1 via the tandem LIM domains.
messages: Nucleus
messages: Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity).
messages: The LIM domains exert a negative regulatory function and disruption of the LIM domains produces an activated form. In addition, two activation domains and a negative regulatory domain exist C-terminally to the homeobox (By similarity).

10116:Gbx1
gene id: 10116:Gbx1
uniprot id: F1M7G6
names: Subcellular Location Annotation
messages: Nucleus

10116:LOC103689958
gene id: 10116:LOC103689958
uniprot id: A0A0G2JXQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Pgs1
gene id: 10116:Pgs1
uniprot id: A6HL41
uniprot id: D4A5W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

10116:Srp54a
gene id: 10116:Srp54a
uniprot id: Q6AYB5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity). Interacts with RNPS1 (By similarity). Interacts with the SRP receptor subunit SRPRA (By similarity).
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (By similarity). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (By similarity). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (By similarity). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus speckle
messages: The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA (By similarity). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity). SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity).

10116:Lad1
gene id: 10116:Lad1
uniprot id: A6ICG6
uniprot id: G3V779
names: Function
names: Subcellular Location Annotation
messages: Anchoring filament protein which is a component of the basement membrane zone.
messages: basement membrane

10116:Odf2
gene id: 10116:Odf2
uniprot id: A0A0H2UHM4
uniprot id: A0A8L2UM86
uniprot id: A6JTT1
uniprot id: A6JTT2
uniprot id: G3V7X0
uniprot id: Q6AYX5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ODF2 family.
messages: Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly.
messages: Self-associates. Associates with microtubules and forms a fibrillar structure partially linked to the microtubule network. Interacts through its C-terminus with PLK1. Interacts with ODF1 (PubMed:9045620). Interacts with MARK4; the interaction is required for localization of ODF2 to centrioles (By similarity). Interacts with TSSK4 (By similarity). Interacts with AKNA (By similarity). Interacts with QRICH2 (By similarity). Interacts with CFAP58 (By similarity).
messages: Testis-specific (PubMed:9045620). Expressed in the proximal compartment of the elongated spermatid tail; later expression progresses to the distal spermatid tail compartment located in the lumen of the seminiferous epithelium (PubMed:9698445). In spermatids (stages II-III) expression of the tails peaks and remains strong during the remaining steps of spermiogenesis (at protein level) (PubMed:9698445). Expression correlates with the onset of spermatogenesis and is first detected at 30 days. Higher expression is seen in testis of 40-day-old and adults that are older than 50 days (PubMed:9092585). No expression is seen in 10- and 20-day-old testes (PubMed:9092585).
messages: Tyrosine phosphorylated. Phosphorylated on Ser-90 by TSSK4.
messages: centriole
messages: centrosome
messages: cilium
messages: flagellum
messages: spindle pole

10116:Timm8a1
gene id: 10116:Timm8a1
uniprot id: A6IVF6
uniprot id: Q9WVA1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Heterohexamer; composed of 3 copies of TIMM8A and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22 (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM8A from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

10116:Ciapin1
gene id: 10116:Ciapin1
uniprot id: A6JY45
uniprot id: Q5XID1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

10116:Nog
gene id: 10116:Nog
uniprot id: A6HI02
uniprot id: G3V8X8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
messages: Secreted

10116:Actn2
gene id: 10116:Actn2
uniprot id: A6KN31
names: Similarity
messages: Belongs to the alpha-actinin family.

10116:Stard8
gene id: 10116:Stard8
uniprot id: D4A5B9
names: Subcellular Location Annotation
messages: Cytoplasm

10116:Itga4
gene id: 10116:Itga4
uniprot id: A6HMK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

10116:Slc29a4
gene id: 10116:Slc29a4
uniprot id: A6K1P5
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

10116:Taar3
gene id: 10116:Taar3
uniprot id: D8KZH7
uniprot id: Q5QD24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Olfactory receptor activated by several primary trace amines, including isoamylamine. Activated by isoamylamine and cyclohexylamine, but not to the corresponding alcohols, isoamylalcohol and cyclohexanol. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase (By similarity).

10116:LOC24906
gene id: 10116:LOC24906
uniprot id: O55006
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CNF-like-inhibitor family.
messages: Expressed abundantly in bone, including the lengthening growth plate where cartilage is remodeled into bone.
messages: May play a novel role in the growth or remodeling of bone.
messages: N-glycosylated.
messages: Secreted
messages: Up-regulated by estradiol.

10116:Gypc
gene id: 10116:Gypc
uniprot id: Q6XFR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycophorin-C family.
messages: Cell membrane

10116:Tmem129
gene id: 10116:Tmem129
uniprot id: B1WBR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

10116:Coq8a
gene id: 10116:Coq8a
uniprot id: A6JGG2
uniprot id: Q5BJQ0
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adopts an atypical protein kinase-like fold: while it adopts a core fold similar to that of well-characterized protein kinase-like domains, a number of features are positioned to inhibit the kinase activity: (1) an atypical AAAS motif in an alanine-rich (A-rich) loop that replaces the canonical glycine-rich (G-rich) nucleotide-binding loop and limits ATP binding by establishing an unusual selectivity for ADP and (2) an N-terminal domain, containing the KxGQ motif, that completely occludes the typical substrate binding pocket. Nucleotide-binding opens the substrate binding pocket and flips the active site from inside the hydrophobic core into a catalytically competent, solvent-exposed posture.
messages: Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. Shows an unusual selectivity for binding ADP over ATP.
messages: Autoinhibited by the N-terminal domain, containing the KxGQ motif, that completely occludes the typical substrate binding pocket. Nucleotide-binding relieves inhibition.
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Homodimer; homodimerizes via its transmembrane region. Interacts with the multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Membrane
messages: Mitochondrion

10116:Esrrb
gene id: 10116:Esrrb
uniprot id: P11475
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by PCAF/KAT2 (in vitro).
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a monomer (By similarity). Interacts with NR0B1; represses ESRRB activity at the GATA6 promoter. Interacts with NANOG; reciprocally modulates their transcriptional activities and activates POU5F1 expression. Interacts with NCOA3; mediates the interaction between ESRRB and RNA polymerase II complexes and allows NCOA3 corecruitment to ESRRB, KLF4, NANOG, and SOX2 enhancer regions to trigger ESRRB-dependent gene activation involved in self-renewal and pluripotency. Interacts with KDM1A; co-occupes the core set of ESRRB targets including ELF5 and EOMES. Interacts with the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12; ESRRB is probably not a core component of the integrator complex and associates to integrator via its interaction with INTS1 and INTS9; attracts the transcriptional machinery. Interacts with JARID2. Interacts with POU5F1; recruits ESRRB near the POU5F1-SOX2 element in the NANOG proximal promoter leading to activation of NANOG expression; the interaction is DNA independent (By similarity).
messages: Chromosome
messages: Cytoplasm
messages: Nucleus
messages: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (By similarity). Plays a role, in a LIF independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (By similarity). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (By similarity). During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity).
messages: Was originally (PubMed:3267207) thought to originate from human but was later shown (PubMed:10072763) to be derived from rat.

10116:Myo7b
gene id: 10116:Myo7b
uniprot id: A0A0G2K3A7
uniprot id: F1M885
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: cytoskeleton

10116:Mboat7
gene id: 10116:Mboat7
uniprot id: A6KS21
uniprot id: B5DFK0
uniprot id: G3V7N6
names: Subcellular Location Annotation
messages: Membrane

10116:Mllt11
gene id: 10116:Mllt11
uniprot id: Q5M971
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MLLT11 family.
messages: Cofactor for the transcription factor TCF7. Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T-cell fate.
messages: Cytoplasm
messages: Interacts with HSPA8 and LAMP2 isoform A; the interaction may target MLLT11 for degradation via chaperone-mediated autophagy. Interacts with TCF7.
messages: Nucleus
messages: Ubiquitinated, leading to degradation.
messages: centrosome

10116:Tom1l1
gene id: 10116:Tom1l1
uniprot id: B5DFM1
names: Similarity
messages: Belongs to the TOM1 family.

10116:Htr7
gene id: 10116:Htr7
uniprot id: A6I144
uniprot id: P32305
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Thalamus, hypothalamus, and the hippocampal rudiments.
messages: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. This receptor is implicated in the regulation of mammalian circadian rhythms.

10116:Pgf
gene id: 10116:Pgf
uniprot id: A6JE11
uniprot id: Q63434
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF.
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Also promotes cell tumor growth (By similarity).
messages: Secreted

10116:Trpt1
gene id: 10116:Trpt1
uniprot id: A6HZM9
uniprot id: D3ZBT6
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

10116:Cxcl1
gene id: 10116:Cxcl1
uniprot id: P14095
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At least expressed in the lung and trachea.
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: By lipopolysaccharides (LPS) and inflammation.
messages: Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation.
messages: Monomer and homodimer.
messages: Secreted

10116:Acsl5
gene id: 10116:Acsl5
uniprot id: A6JHY8
uniprot id: O88813
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 5 rat isozymes encoded by different genes have been described. ACSL6 corresponds to isozyme 2 (ACS2).
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:28209804). ACSL5 may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL at the villus tip of the crypt-villus axis of the small intestine (By similarity). May have a role in the survival of glioma cells (By similarity). May activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage. It was suggested that it may also stimulate fatty acid oxidation. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Expressed most abundantly in the small intestine, and to a much lesser extent in the lung, liver, adrenal gland, adipose tissue and kidney.
messages: Expression decreases in response to fast and increases after high sucrose diet.
messages: Membrane
messages: Mitochondrion
messages: Mitochondrion outer membrane

10116:Abhd12
gene id: 10116:Abhd12
uniprot id: Q6AYT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serine esterase family.
messages: Endoplasmic reticulum membrane
messages: Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (By similarity).

10116:Ldlrad1
gene id: 10116:Ldlrad1
uniprot id: D4A460
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Ift70a1
gene id: 10116:Ift70a1
uniprot id: A0A8I5ZT76
uniprot id: A6HMG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

10116:Recql4
gene id: 10116:Recql4
uniprot id: A6HSC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

10116:Hint1
gene id: 10116:Hint1
uniprot id: P62959
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HINT family.
messages: Cytoplasm
messages: Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Hydrolyzes adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate) (By similarity). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester (By similarity). Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide (By similarity). In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1 (By similarity). Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Also exhibits SUMO-specific isopeptidase activity, deconjugating SUMO1 from RANGAP1 and RGS17 (By similarity).
messages: Homodimer (By similarity). Interacts with CDK7 (By similarity). Interacts with RUVBL1 and RUVBL2 and is associated with the LEF1/TCF1-CTNNB1 complex and with a KAT5 histone acetyltransferase complex (By similarity). Identified in a complex with MITF and CTNNB1 (By similarity). Interacts with CDC34 and RBX1, and is part of a SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Interacts with SUMO1, SUMO2 and RGS17 (By similarity). Interacts with the Ten-1 ICD form of TENM1 (By similarity). Interacts with CALM1; interaction increases in the presence of calcium ions (By similarity).
messages: Nucleus
messages: Was originally thought to be a protein kinase C inhibitor and to bind zinc in solution. Both seem to be incorrect.

10116:Trex1
gene id: 10116:Trex1
uniprot id: F7F432
uniprot id: Q5BK16
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

10116:Megf6
gene id: 10116:Megf6
uniprot id: O88281
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in lung.
messages: Secreted

10116:Mrm1
gene id: 10116:Mrm1
uniprot id: A6HHL7
uniprot id: D3ZK81
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

10116:Ddx1
gene id: 10116:Ddx1
uniprot id: A6HAQ9
uniprot id: Q641Y8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity).
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1; this complex exists in resting cells with or without poly(I:C) RNA ligand stimulation (By similarity). Interacts with DHX36 (By similarity). Interacts (via B30.2/SPRY domain) with DDX21 (via N-terminus); this interaction serves as bridges to TICAM1 (By similarity). Interacts with FAM98A (via N- and C-terminus) (By similarity). Interacts with PHF5A (via C-terminus) (By similarity). Interacts with MBNL1 (By similarity). Interacts with CSTF2 (By similarity). Interacts with HNRNPK (By similarity). Interacts with ATM (By similarity). Interacts with RELA (via C-terminus) (By similarity). Component of the tRNA-splicing ligase complex (By similarity). Interacts with PQBP1 (By similarity). Interacts with ERCC6 (By similarity).
messages: Mitochondrion
messages: Nucleus
messages: Phosphorylated by ATM kinase; phosphorylation is increased in response to ionizing radiation (IR).
messages: RNA helicase.
messages: The helicase domain is involved in the stimulation of RELA transcriptional activity.
messages: cytosol

10116:Stx6
gene id: 10116:Stx6
uniprot id: Q63635
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane
messages: Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity). Binds EEA1 (PubMed:10506127). Interacts with VPS45A and GOPC (By similarity). Interacts with MARCHF2; the interaction promotes MARCHF2-mediated ubiquitination and degradation of CFTR (PubMed:15689499). Interacts with MARCHF3 (PubMed:16428329). Interacts with BLTP3B (via C-terminal coiled-coil domain) (PubMed:20163565). Interacts with BAIAP3; this interaction is increased in the presence of calcium (By similarity). Interacts (via N-terminus) with VPS51 (PubMed:30962439). Interacts with VPS13B (PubMed:30962439).
messages: Recycling endosome membrane
messages: SNARE promoting movement of transport vesicles to target membranes (PubMed:30962439). Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking (PubMed:30962439). Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway (PubMed:30962439).
messages: Widely expressed, with relatively higher expression in brain, lung and kidney.
messages: trans-Golgi network membrane

10116:Ptprm
gene id: 10116:Ptprm
uniprot id: F1LPJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

10116:Inpp5d
gene id: 10116:Inpp5d
uniprot id: P97573
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated upon translocation to the sites of synthesis of PtdIns(3,4,5)P3 in the membrane.
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with tyrosine phosphorylated forms of SHC1 (PubMed:8910587). Interacts with tyrosine phosphorylated form of DOK1 (By similarity). Interacts with tyrosine phosphorylated form of DOK3 (By similarity). Interacts with tyrosine phosphorylated form of SLAMF1/CD150 (By similarity). Interacts with PTPN11/SHP-2 in response to IL-3 (By similarity). Interacts with receptor EPOR (By similarity). Interacts with receptors MS4A2/FCER1B and FCER1G (PubMed:8910587). Interacts with receptors FCGR2B and FCGR3 (By similarity). Interacts with receptor FCGR2A, leading to regulate gene expression during the phagocytic process (By similarity). Interacts with GRB2 (PubMed:8910587). Interacts with PLCG1 (By similarity). Interacts with tyrosine kinases SRC and TEC (By similarity). Interacts with c-Met/MET (By similarity). Interacts with MILR1 (tyrosine-phosphorylated) (By similarity). Can weakly interact (via NPXY motif 2) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (By similarity). Interacts (via SH2 domain) with tyrosine phosphorylated KLRC1 (via ITIM).
messages: Membrane raft
messages: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:8910587). Also able to hydrolyze the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (By similarity). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression (By similarity).
messages: The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain.
messages: The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or PTPN11/SHP-2. It competes with that of GRB2 for binding to phosphorylated SHC1 to inhibit the Ras pathway. It is also required for tyrosine phosphorylation (By similarity).
messages: Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli such as cytokines, growth factors, antibodies, chemokines, integrin ligands and hypertonic and oxidative stress. Phosphorylated upon IgG receptor FCGR2B-binding.
messages: cytoskeleton

10116:Polr2h
gene id: 10116:Polr2h
uniprot id: A6JS83
uniprot id: G3V678
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

10116:Casp3
gene id: 10116:Casp3
uniprot id: A6JPM9
uniprot id: P55213
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase C14A family.
messages: Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.
messages: Cytoplasm
messages: Expressed in heart, brain, liver, and muscle but not in kidney or testis.
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce.
messages: Highly expressed in neuron-enriched regions of the developing brain, but down-regulated to low levels in the adult brain.
messages: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction. Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (By similarity). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (By similarity).
messages: S-nitrosylated on its catalytic site cysteine in unstimulated cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.

10116:Plpp1
gene id: 10116:Plpp1
uniprot id: A6I5P9
uniprot id: G3V9Y2
uniprot id: Q6P766
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

10116:Hbb
gene id: 10116:Hbb
uniprot id: P02091
names: Caution
names: Function
names: Polymorphism
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: In rats there are two non-allelic alpha chains and two non-allelic beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: PubMed:8334153 incorrectly assigned their sequence fragment as a fatty acid-binding protein.
messages: Red blood cells.

10116:Micb
gene id: 10116:Micb
uniprot id: A0A0G2K7V7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MHC class I family.
messages: Binds to heparan sulfate proteoglycans on the surface of fibroblast cells.
messages: Cell membrane
messages: Heterodimer with B2M.
messages: Lacks key residues involved in peptide docking, suggesting that this is a non-classical MHC class I protein which does not play a role in antigen presentation.
messages: Ubiquitously expressed in neonatal and adult tissues.

10116:Fgfbp3
gene id: 10116:Fgfbp3
uniprot id: A6I159
uniprot id: D3ZVI0
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

10116:Rassf9
gene id: 10116:Rassf9
uniprot id: O88869
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Endosome
messages: Interacts with PAM.
messages: May play a role in regulating vesicuar trafficking in cells.
messages: Testis, kidney, skeletal muscle, liver, lung, brain, heart, pituitary gland, adrenal gland and ovary.

10116:Cdk2ap1
gene id: 10116:Cdk2ap1
uniprot id: B0BN48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK2AP family.
messages: Nucleus

10116:Mfap3
gene id: 10116:Mfap3
uniprot id: Q6AYF7
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of the elastin-associated microfibrils.
messages: Glycosylated.

10116:Pigv
gene id: 10116:Pigv
uniprot id: A6ISY4
uniprot id: Q5KR61
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane
messages: Not N-glycosylated.

10116:Or5p79
gene id: 10116:Or5p79
uniprot id: A0A0G2JWZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Coa7
gene id: 10116:Coa7
uniprot id: A6JYU7
uniprot id: D4AC65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space
messages: Required for assembly of mitochondrial respiratory chain complexes.

10116:Mdfic
gene id: 10116:Mdfic
uniprot id: A6IE11
uniprot id: D3ZVM7
names: Similarity
messages: Belongs to the MDFI family.

10116:Primpol
gene id: 10116:Primpol
uniprot id: D4A8C0
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

10116:Mup5
gene id: 10116:Mup5
uniprot id: Q9JJI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

10116:Rab33a
gene id: 10116:Rab33a
uniprot id: A6JMQ7
uniprot id: D3ZCU8
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

10116:Htra4
gene id: 10116:Htra4
uniprot id: D3ZKF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Secreted
messages: Serine protease.

10116:Acsm3
gene id: 10116:Acsm3
uniprot id: A6I8M8
uniprot id: Q6SKG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms (By similarity).
messages: Mitochondrion
messages: Mitochondrion matrix

10116:Gpat2
gene id: 10116:Gpat2
uniprot id: D3ZI76
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the GPAT/DAPAT family.
messages: Expressed in spermatocytes and spermatides.
messages: Inhibited by N-ethylmaleimide (NEM).
messages: Interacts with PIWIL2.
messages: Mitochondrion outer membrane
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
messages: Transfers an acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate producing a lysophosphatidic acid (LPA), an essential step for the triacylglycerol (TAG) and glycerophospholipids. In vitro also transfers an acyl-group from acyl-ACP to the LPA producing a phosphatidic acid (PA). Prefers arachidonoyl-CoA as the acyl donor. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity.

10116:Smad5
gene id: 10116:Smad5
uniprot id: B1WBR0
uniprot id: Q9R1V3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Homodimer. Forms trimers with the co-SMAD SMAD4 (By similarity). Interacts with PEBP2-alpha subunit and SMURF1. Interacts with SUV39H1 and SUV39H2. Interacts (via MH2 domain) with LEMD3. Interacts with WWP1. Interacts with TMEM119 (By similarity). Interacts with ZNF8. Interacts with RANBP3L. Interacts with HK1. Interacts with HGS; this interaction attenuates BMP signaling (By similarity).
messages: Mitochondrion
messages: Nucleus
messages: Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.
messages: Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis. Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form an heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network. Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes. Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis.
messages: Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.

10116:Ddr1
gene id: 10116:Ddr1
uniprot id: A0A0G2K7S7
uniprot id: A0A0G2KAB1
uniprot id: A6KT95
uniprot id: B2GVB6
names: Subcellular Location Annotation
messages: Membrane

10116:Cxcr1
gene id: 10116:Cxcr1
uniprot id: A6JVS8
uniprot id: P70612
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with IL8. Interacts with GNAI2.
messages: Membrane
messages: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

10116:Or5ac22
gene id: 10116:Or5ac22
uniprot id: M0R9P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Or12e13b
gene id: 10116:Or12e13b
uniprot id: A0A0G2JUW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Stag2
gene id: 10116:Stag2
uniprot id: A0A0G2K4D9
uniprot id: D3ZXT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

10116:Mbl1
gene id: 10116:Mbl1
uniprot id: P19999
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Calcium-dependent lectin (PubMed:1436090, PubMed:9033386, PubMed:11850428). Plays a role in the innate immune response by binding mannose, fucose and N-acetylglucosamine moieties on different microorganisms and mediating activation of the lectin complement pathway (PubMed:3584121). Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).
messages: Detected in blood serum (at protein level).
messages: Homotrimer (PubMed:7704532, PubMed:9033386, PubMed:11850428, PubMed:25419660). Forms higher oligomeric complexes formed by the association of two, three or more homotrimers (PubMed:10903744, PubMed:25419660). Oligomerization occurs in the endoplasmic reticulum (By similarity). Interacts with MASP1 and MASP2 (PubMed:10913141).
messages: Hydroxylated on lysine and proline residues within the collagen-like domain.
messages: O-glycosylated. O-linked glycans on hydroxylysine residues consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.
messages: Secreted
messages: The helical collagen-like domains from three protein chains assemble into a coiled coil and mediate trimerization.

10116:Or2p2
gene id: 10116:Or2p2
uniprot id: A6KN61
uniprot id: D3ZSB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Slc6a1
gene id: 10116:Slc6a1
uniprot id: A6IBU6
uniprot id: P23978
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily.
messages: Brain.
messages: Cell membrane
messages: Inhibited by nipecotic acid, cis-3-aminocyclohexane carboxylic acid and 2,4-diaminobutyric acid.
messages: Interacts (via PDZ domain-binding motif) with PALS1; interaction increases SLC6A1-mediated GABA uptake.
messages: Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:1975955, PubMed:18054861). The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (PubMed:18054861, PubMed:21775701). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (PubMed:18054861, PubMed:21775701). Also mediates sodium- and chloride-dependent transport of hypotaurine (By similarity).
messages: Membrane
messages: Presynapse
messages: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

10116:Tubg1
gene id: 10116:Tubg1
uniprot id: P83888
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Interacts with TUBGCP2, TUBGCP3 and B9D2. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2. Interacts with CIMAP3. Interacts with SAS6 and NUP62 at the centrosome (By similarity). Interacts with EML3 (phosphorylated form) and HAUS8 (By similarity).
messages: Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).
messages: centrosome
messages: spindle

10116:Timm9
gene id: 10116:Timm9
uniprot id: A6HC17
uniprot id: Q9WV97
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9, TIMM10/TIM10A and FXC1/TIM10B (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

10116:Or4p22e
gene id: 10116:Or4p22e
uniprot id: A0A0G2K4B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Naf1
gene id: 10116:Naf1
uniprot id: Q52KK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAF1 family.
messages: Cytoplasm
messages: During assembly of the complex, component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) which contains NOLA2/NHP2, NOLA3/NOP10, NAF1 and DKC1/NOLA4. Interacts directly with DKC1/NOLA4 (By similarity).
messages: Nucleus
messages: RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4 (By similarity).

10116:Eya4
gene id: 10116:Eya4
uniprot id: A0A8I6B402
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

10116:Clrn3
gene id: 10116:Clrn3
uniprot id: A6HX61
uniprot id: Q6AYR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

10116:Folh1
gene id: 10116:Folh1
uniprot id: P70627
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Binds 2 Zn(2+) ions per subunit. Required for NAALADase activity.
messages: Cell membrane
messages: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides (By similarity). In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate.
messages: Homodimer.
messages: Probably inactive.
messages: The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal.
messages: The NAALADase activity is inhibited by beta-NAAG, quisqualic acid and 2-(phosphonomethyl)glutaric acid (PMG).
messages: Widely expressed throughout brain regions with highest levels in the hippocampus, dentate gyrus, priform cortex, choroid plexus of ventricles, pineal gland, anterior lobe of the pituitary gland and supraoptic nucleus. High levels also found in the cerebral cortex, substantia nigra, pontine nucleus and the granule cell layer of cerebellum. Highly expressed in astrocytes and non-myelinating Schwann cells. Also expressed in kidney, localizing to the proximal brush border of the renal tube.

10116:Taar7a
gene id: 10116:Taar7a
uniprot id: A6JUM6
uniprot id: Q923Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

10116:Tmprss3
gene id: 10116:Tmprss3
uniprot id: A6JJZ0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Zfp90
gene id: 10116:Zfp90
uniprot id: Q4V8A8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes.
messages: Interacts (via N- and C-termini) with REST (via zinc-finger DNA-binding domain); the interaction inhibits REST repressor activity.
messages: Nucleus

10116:Or1j13c
gene id: 10116:Or1j13c
uniprot id: D3ZVZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Armcx4
gene id: 10116:Armcx4
uniprot id: A0A8I5ZMH4
uniprot id: D3ZV39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane
messages: Mitochondrion outer membrane

10116:Or1e23
gene id: 10116:Or1e23
uniprot id: A0A8I6A2D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Thbs3
gene id: 10116:Thbs3
uniprot id: A0A0G2JZH3
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Smarca1
gene id: 10116:Smarca1
uniprot id: A0A8I6AH59
uniprot id: D3ZIE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

10116:Or2n1h
gene id: 10116:Or2n1h
uniprot id: A0A8I6A733
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Klc2
gene id: 10116:Klc2
uniprot id: B2GV74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

10116:Apbb3
gene id: 10116:Apbb3
uniprot id: O35827
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed predominantly in brain and testis.
messages: Interacts with APP (via intracellular domain) (PubMed:9461550). Interacts with APLP1 and APLP2 (via intracellular domain) (By similarity).
messages: May modulate the internalization of amyloid-beta precursor protein.
messages: Nucleus

10116:Gjc2
gene id: 10116:Gjc2
uniprot id: Q80XF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A connexon is composed of a hexamer of connexins. Interacts with TJP1 (By similarity).
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Mainly expressed by oligodendrocytes in the central nervous system. Expressed in optic nerve (at protein level).
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems (By similarity).
messages: gap junction

10116:Fut11
gene id: 10116:Fut11
uniprot id: A6KKP8
uniprot id: Q68FV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Has fucosyltransferase activity toward biantennary N-glycan acceptors. Does not fucosylate GlcNAc residue within type 2 lactosamine unit.
messages: Membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

10116:Atp5pb
gene id: 10116:Atp5pb
uniprot id: A6HUP1
uniprot id: P19511
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

10116:Tmem30c
gene id: 10116:Tmem30c
uniprot id: A6IQM7
uniprot id: D4AAH8
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

10116:Atf5
gene id: 10116:Atf5
uniprot id: Q6P788
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated at Lys-29 by EP300, the acetylation enhances the interaction with CEBPB, DNA-binding and transactivation activity.
messages: Belongs to the bZIP family.
messages: Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 (By similarity). Interacts with CCND3, but not with CCND1 or CCND2. Interacts with HSPA1A or HSPA1B; the interaction protects ATF5 from degradation via proteasome-dependent and caspase-dependent processes. Interacts (via C-terminal region) with NPM1 (via C-terminal region); the interaction leads to loss of association between HSPA1A or HSPA1B and ATF5 and promotes ATF5 degradation via proteasome-dependent and caspase-dependent processes. Interacts with NLK; the interaction stabilizes ATF5 at the protein level in a kinase-independent manner. Interacts with alpha-tubulin, gamma-tubulin members TUBGCP2 and TUBGCP4, PCNT; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome (By similarity). Interacts with CEBPB and EP300; EP300 is required for ATF5 and CEBPB interaction and DNA binding (By similarity) (PubMed:21791614).
messages: Cytoplasm
messages: Down-regulated during neuronal differentiation. Down-regulated by pro-apoptotic stimuli (PubMed:21212266).
messages: Expressed in embryonic nasal epithelium, dorsal root, trigeminal ganglia, brain and liver. Within the brain, expression is highest in the ventricular zone and decreased in structures containing migrating and postmitotic neurons (at protein level).
messages: Nucleus
messages: Phosphorylated by NLK, probably at Ser-92 and Ser-126.
messages: Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (By similarity) (PubMed:19531563, PubMed:21212266). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity) (PubMed:12805299). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation. Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation. Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (By similarity) (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver. In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase. May act as a negative regulator of IL1B transduction pathway in liver. Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members. Besides its function of transcription factor, acts as a cofac…
messages: Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome.
messages: Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome. Cisplatin inhibits ubiquitination and proteasome-mediated degradation by inhibiting the interaction with CDC34. Ubiquitination and degradation by the proteasome are inhibited by NLK in a kinase-independent manner.
messages: centrosome

10116:Gsta5
gene id: 10116:Gsta5
uniprot id: A0A096MIU0
uniprot id: P04903
uniprot id: Q4FZZ3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Alpha family.
messages: Catalyzes the conjugation of glutathione to a large variety of electrophilic compounds.
messages: Cytoplasm
messages: Homodimer or heterodimer of GSTA1 and GSTA2.
messages: In addition to its enzymatic activity, the homodimer of Ya chains, called ligandin, binds various organic anions, xenobiotics, and azocarcinogen dyes.

10116:Igf2r
gene id: 10116:Igf2r
uniprot id: A6KJW4
uniprot id: G3V824
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Zdhhc15
gene id: 10116:Zdhhc15
uniprot id: Q2TGJ4
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Autopalmitoylated (in vitro).
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Golgi apparatus membrane
messages: Highly expressed during early stages of development at 17 dpc and postnatal day 10 (P10) but significantly reduced in the adult brain.
messages: In brain, expressed in both excitatory and inhibitory neurons but not expressed by glial cells.
messages: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (By similarity). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoylates IGF2R and SORT1, promoting their partitioning to an endosomal membrane subdomain where they can interact with the retromer cargo-selective complex (By similarity). Thereby, regulates retrograde transport from endosomes to the Golgi apparatus of these lysosomal sorting receptors and plays a role in trafficking of lysosomal proteins (By similarity). In the nervous system, catalyzes the palmitoylation of DLG4/PSD95 and regulates its synaptic clustering and function in synaptogenesis (PubMed:31189538). Could be involved in the differentiation of dopaminergic neurons and the development of the diencephalon (By similarity). Could also catalyze the palmitoylation of GAP43 (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Could also palmitoylate FYN as shown in vitro (By similarity).
messages: Postsynaptic density
messages: The DHHC domain is required for palmitoyltransferase activity.

10116:Snrpf
gene id: 10116:Snrpf
uniprot id: A6IFZ1
uniprot id: D4AAT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

10116:Tas2r104
gene id: 10116:Tas2r104
uniprot id: Q67ES9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Putative taste receptor which may play a role in the perception of bitterness.
messages: Several bitter taste receptors are expressed in a single taste receptor cell.

10116:Atp5f1d
gene id: 10116:Atp5f1d
uniprot id: G3V7Y3
uniprot id: P35434
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
messages: Mitochondrion
messages: Mitochondrion inner membrane

10116:Ret
gene id: 10116:Ret
uniprot id: A6IL58
uniprot id: G3V9H8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated on C-terminal tyrosine residues upon ligand stimulation.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Endosome membrane
messages: Expressed in neurons and kidney glomeruli podocytes (at protein level) (PubMed:18753381). Detected at least in colon, duodenum, adipose tissue, heart, jejenum, lung, muscle, spleen, stomac, testis and thymus (PubMed:28846099).
messages: Phosphorylated form interacts with the PBT domain of DOK2, DOK4 and DOK5 (By similarity). The phosphorylated form interacts with PLCG1 and GRB7 (By similarity). Interacts (not phosphorylated) with PTK2/FAK1 (via FERM domain) (By similarity). Extracellular cell-membrane anchored RET cadherin fragments form complex in neurons with reduced trophic status, preferentially at the contact sites between somas (By similarity). Interacts with AIP in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex (By similarity). Binds to ARTN (By similarity). Interacts (inactive) with CBLC and CD2AP; dissociates upon activation by GDNF which increases CBLC:CD2AP interaction (PubMed:18753381). Interacts (via the extracellular domain) with GFRAL (via the extracellular domain); the interaction mediates cellular signaling upon interaction of GFRAL with its ligand GDF15. Interaction with GFRAL requires previous GDF15-binding to GFRAL (By similarity). Interacts with GFRA1; in the presence of SORL1, the GFRA1/RET complex is targeted to endosomes (PubMed:23333276). Interacts with GFRA1; in the presence of SORL1, the GFRA1/RET complex is targeted to endosomes (PubMed:23333276). Interacts with GDNF (By similarity).
messages: Proteolytically cleaved by caspase-3. The soluble RET kinase fragment is able to induce cell death. The extracellular cell-membrane anchored RET cadherin fragment accelerates cell adhesion in sympathetic neurons (By similarity).
messages: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.
messages: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration (By similarity). Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways (By similarity).

10116:Dab2ip
gene id: 10116:Dab2ip
uniprot id: Q6P730
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Cytoplasm
messages: Exists in a closed inactive form by an intramolecular interaction between the N- and the C-terminal domains. The proline-rich motif is critical both for PI3K-AKT activity inhibition and MAP3K5 activation. The PH and C2 domains are necessary for the binding to phosphatidylinositol phosphate. The Ras-GAP domain is necessary for its tumor-suppressive function. The C2 and Ras-GAP domains constitutively bind to MAP3K5 and facilitate the release of 14-3-3 proteins from MAP3K5. The PH and Ras-GAP domains, but not the NPXY motif, are crucial for its cell membrane localization and neuronal migration function. The PH domain is necessary but not sufficient to activate the JNK signaling pathway through ERN1 (By similarity).
messages: Expressed in brain, lung, thymus, bladder and skeletal muscle. Up-regulatedd during prostate degeneration.
messages: Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate …
messages: In response to TNF-alpha-induction, phosphorylated at Ser-535; phosphorylation leads to a conformational change, and thus, increases its association with 14-3-3 proteins, MAP3K5, RIPK1 and TRAF2 in endothelial cells; also stimulates regulatory p85 subunit sequestring and PI3K-p85 complex activity inhibition.
messages: Membrane
messages: On plasma membrane, exists in an inactive form complexed with TNFR1; in response to TNF-alpha, dissociates from TNFR1 complex, translocates to cytoplasm and forms part of an intracellular signaling complex comprising TRADD, RIPK1, TRAF2 and MAP3K5. Interacts (via NPXY motif) with DAB2 (via PID domain). Interacts (via PH domain) with ERN1. Part of a cytoplasmic complex made of HIPK1, DAB2IP and MAP3K5 in response to TNF-alpha; this complex formation promotes MAP3K5-JNK activation and subsequent apoptosis. Interacts (via N-terminal domain) with JAK2; the interaction occurs in a IFNG/IFN-gamma-dependent manner and inhibits JAK2 autophosphorylation activity. Interacts (via C2 domain) with GSK3B; the interaction stimulates GSK3B kinase activation. Interacts (via C2 domain) with PPP2CA. Interacts (via proline-rich motif) with a regulatory p85 subunit (via SH3 domain) of the PI3K complex; the interaction inhibits the PI3K-AKT complex activity in a TNF-alpha-dependent manner in prostate cancer (PCa) cells. Interacts with AKT1; the interaction is increased in a TNF-alpha-induced manner. Interacts (via C2 domain and active form preferentially) with KDR/VEGFR2 (tyrosine-phosphorylated active form preferentially); the interaction occurs at the late phase of VEGFA response and inhibits KDR/VEGFR2 activity. Interacts (via N-terminus C2 domain) with MAP3K5 ('Ser-966' dephosphorylated form preferentially); the interaction occurs in a TNF-alpha-induced manner. Interacts (via Ras-GAP domain) with the catalytic subunit of protein phosphatase PP2A; the interaction occurs in resting endothelial cells, is further enhanced by TNF-alpha stimulation and is required to bridge PP2A to MAP3K5. Interacts (via C-terminus PER domain) with TRAF2 (via zinc fingers); the interaction occurs in a TNF-alpha-dependent manner. Interacts with 14-3-3 proteins; the interaction occurs in a TNF-alpha-dependent manner. Interacts (via Ras-GAP domain) with RIPK1 (via kinase domain); the interaction occurs in a T…
messages: dendrite

10116:Vipr2
gene id: 10116:Vipr2
uniprot id: P35000
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.

10116:Spx
gene id: 10116:Spx
uniprot id: M0R8L2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a ligand for galanin receptors GALR2 and GALR3 (By similarity). Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes. Also induces contraction of muscarinic-like stomach smooth muscles (PubMed:24550067).
messages: Belongs to the spexin family.
messages: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (PubMed:22038051).
messages: Plays a role as a central modulator of cardiovascular and renal function and nociception. Also plays a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (PubMed:20045034, PubMed:22038051).
messages: Secreted
messages: Up-regulated by enucleation-induced adrenocortical regeneration (at protein level). Up-regulated by dexamethasone (DX) treatment. Down-regulated by adrenocorticotropic hormone (ACTH) treatment. Up-regulated by hypoxia in the carotid body.
messages: Widely expressed; predominantly expressed in epithelial cells in the skin, respiratory, digestive, urinary and reproductive systems, retina, adrenal gland and various brain regions. In the adrenal gland, expressed in parenchymal cells of the cortex and in ganglionic cells and intermingled cortical cells of the medulla. Expressed in the type I glomic cells within the carotid body (at protein level). Widely expressed. Strongly expressed in esophagus, liver, pancreas, kidney, brain, hypothalamus, thyroid and ovary. Expressed in the zona glomerulosa (ZG) and zona fasciculata/reticularis (ZF/R) of the adrenal gland. Also expressed in stomach, lung, skeletal muscle, heart, uterus, spleen, adrenal gland and testis. Weakly expressed in small intestine, thymus, urinary bladder and adenohypophysis. In the brain, is expressed in the Barrington's nucleus, with lesser amount in the ventrolateral caudal periaqueductal gray (PAG) and in the mesopontine tegmentum.
messages: extracellular space
messages: secretory vesicle

10116:ND5
gene id: 10116:ND5
uniprot id: P11661
uniprot id: Q8SEZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

10116:Opa1
gene id: 10116:Opa1
uniprot id: A0A8I5ZZK0
uniprot id: A0A8I6A517
uniprot id: A0A8L2Q0I8
uniprot id: Q2TA68
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by guanine nucleotide exchange factor RCC1L.
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Cleavage at position S2 is mediated by YME1L. Cleavage may occur in the sequence motif Leu-Gln-Gln-Gln-Ile-Gln (LQQQIQ).
messages: Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission (PubMed:16778770). Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Plays a role in mitochondrial genome maintenance (By similarity).
messages: Expressed in brain as well as retinal ganglion, starbust amacrine and horizontal cells of the retina. Absent from nerve fibers and photoreceptor cells of the retina.
messages: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion.
messages: Isoforms that contain the alternative exon 4b (present in isoform 2 and isoform 3, but not in isoform 1) are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: Mitochondrion membrane
messages: Oligomeric complex consisting of membrane-bound and soluble forms of OPA1. Interacts with CHCHD3 and IMMT; these interactions occur preferentially with soluble OPA1 forms. Interacts with RCC1L; this interaction is direct (By similarity). Binds PARL (By similarity). Interacts with PRELID1 (By similarity).
messages: PARL-dependent proteolytic processing releases an antiapoptotic soluble form not required for mitochondrial fusion. Cleaved by OMA1 at position S1 following stress conditions.

10116:Tex10
gene id: 10116:Tex10
uniprot id: A6KJF4
uniprot id: D4A401
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

10116:Csnk2b
gene id: 10116:Csnk2b
uniprot id: A0A8L2UP98
uniprot id: A6KTU1
uniprot id: N0E459
uniprot id: P67874
uniprot id: Q68G11
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Casein kinase II/CK2 is a tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with DYNLT2 (By similarity). Interacts with CD163. Also a component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1 (By similarity). Interacts (via KSSR motif) with ARK2N. Interacts with JUN and ARK2N; mediates the interaction between ARK2N and JUN (By similarity).
messages: Nucleus
messages: Phosphorylated by alpha subunit. Also a component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation (By similarity).
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:16818610). Participates in Wnt signaling (By similarity).
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
messages: Tetramer of two alpha and two beta subunits.
messages: The KSSR motif is part of a protein interaction pocket that mediates interaction with cellular and viral proteins.

10116:Mok
gene id: 10116:Mok
uniprot id: F7F4B1
uniprot id: Q6AXN5
names: Similarity
messages: Belongs to the protein kinase superfamily.

10116:Or4f7b
gene id: 10116:Or4f7b
uniprot id: A0A8I6ABG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Dgat1
gene id: 10116:Dgat1
uniprot id: Q8BHI5
uniprot id: Q9ERM3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats. In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (By similarity). Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly (By similarity). In contrast to DGAT2 it is not essential for survival (By similarity). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (By similarity). Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity).
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane
messages: The MBOAT fold forms a reaction chamber in the endoplasmic reticulum membrane that encloses the active sites. The reaction chamber has a tunnel to the cytosolic side and its entrance recognizes the hydrophilic CoA motif of an acyl-CoA molecule. The chamber has separate entrances for each of the two substrates, acyl-CoA and 1,2-diacyl-sn-glycerol.
messages: The disordered N-terminal region is required for the diacylglycerol O-acyltransferase activity and may regulate enzymatic function via its interaction with the MBOAT fold.

10116:Piezo2
gene id: 10116:Piezo2
uniprot id: A0A8I6A0I2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIEZO (TC 1.A.75) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Ppdpf
gene id: 10116:Ppdpf
uniprot id: A6KM38
uniprot id: Q5PR01
names: Function
names: Similarity
messages: Belongs to the PPDPF family.
messages: Probable regulator of exocrine pancreas development.

10116:Atg13
gene id: 10116:Atg13
uniprot id: A6HNE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

10116:Upb1
gene id: 10116:Upb1
uniprot id: Q03248
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Allosteric enzyme with positive cooperativity toward the substrate N-carbamoyl-beta-alanine at low substrate concentrations (below 12 nM). Displays no cooperativity at substrate levels above 12 nM.
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BUP family.
messages: Catalyzes a late step in pyrimidine degradation. Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide. Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide.
messages: Cytoplasm
messages: Detected in liver (at protein level).
messages: Homodimer, homotetramer, homooctamer; can also form higher homooligomers.
messages: The N-terminus is blocked.
messages: The purified enzyme was shown to contain 1.8 zinc atoms per subunit, and sequence analysis was used to predict the zinc binding site (PubMed:8449931). The crystal structure of the human ortholog indicates a lack of bound zinc ions, and shows that the residues that were predicted to bind zinc are too far apart in space to form a zinc binding site (By similarity).

10116:Or5k3
gene id: 10116:Or5k3
uniprot id: A0A8I6AS28
uniprot id: A6IQJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:LOC690000
gene id: 10116:LOC690000
uniprot id: D3ZWS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane

10116:Apba1
gene id: 10116:Apba1
uniprot id: O35430
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Brain. Detected in the cerebellum, hippocampus, olfactory system, piriform and entorhinal cortex, supraoptic nucleus of the hypothalamus, substantia nigra, and other mesencephalic areas.
messages: Composed of an N-terminal domain that binds Munc18-1 and LIN-2/CASK, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.
messages: Cytoplasm
messages: Golgi apparatus
messages: Nucleus
messages: Part of a multimeric complex containing STXBP1 and STX1A. Interacts with STXBP1 (By similarity). Component of the brain-specific heterotrimeric complex (LIN-10-LIN-2-LIN-7 complex) composed of at least APBA1, CASK, and LIN7, which associates with the motor protein KIF17 to transport vesicles along microtubules (By similarity). Within the complex, interacts (via PDZ domain) with the motor protein KIF17; the interaction is direct and is required for association of KIF17 with the cargo that is to be transported (By similarity). Binds to the cytoplasmic domain of amyloid protein (APP) (By similarity). Interacts (via PDZ 1 and 2 domains) with FSPB (By similarity). Isoform 2 interacts (via its truncated PID domain) with active, GTP-bound RAB6A and RAB6B (By similarity).
messages: Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.
messages: The PID domain, truncated by 11 amino acids, as observed in isoform 2, but not full-length, mediates the interaction with RAB6A.
messages: The autoinhibitory helix linker occludes the APP binding site.
messages: This isoform interacts with RAB6 GTPases.
messages: perinuclear region

10116:Kif5c
gene id: 10116:Kif5c
uniprot id: P56536
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
messages: Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
messages: Microtubule-associated force-producing protein that may play a role in organelle transport (By similarity). Has ATPase activity (PubMed:27452403). Involved in synaptic transmission (By similarity). Mediates dendritic trafficking of mRNAs (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (PubMed:23576431).
messages: Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1. Interacts with TRAK1. Interacts with ZFYVE27 (By similarity). Interacts with KLC3 (PubMed:11319135).
messages: cytoskeleton
messages: dendrite

10116:Osbp2
gene id: 10116:Osbp2
uniprot id: A6IKC8
uniprot id: D3ZHG4
names: Similarity
messages: Belongs to the OSBP family.

10116:Fscn3
gene id: 10116:Fscn3
uniprot id: Q6AXQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

10116:Ppp1r9a
gene id: 10116:Ppp1r9a
uniprot id: A6IDS9
uniprot id: O35867
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction.
messages: Brain, and widely expressed in neural tissue. Highly concentrated in synapses of developed neurons. In developing neurons, concentrated in the lamellipodia of the growth cone.
messages: Interacts with p70-S6K via its PDZ domain.
messages: Possibly exists as a homodimer, homotrimer or a homotetramer. Interacts with F-actin, protein phosphatase 1 (PP1), neurabin-2, TGN38 and p70-S6K.
messages: The PP1 binding region is natively unstructured, upon PP1 binding, it acquires structure, blocks a substrate-binding site, and restricts PP1 phosphatase specificity to a subset of substrates.
messages: cytoskeleton
messages: synaptosome

10116:Cd40lg
gene id: 10116:Cd40lg
uniprot id: F7EMJ0
uniprot id: Q9Z2V2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer (By similarity). Interacts with CD28 (By similarity). CD40 ligand, soluble form: Exists as either a monomer or a homotrimer (By similarity). Forms a ternary complex between CD40 and integrins for CD40-CD40LG signaling (By similarity).
messages: Homotrimer.
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.

10116:Tac1
gene id: 10116:Tac1
uniprot id: A6IDV8
uniprot id: A6IDV9
uniprot id: A6IDW0
uniprot id: A6IDW1
uniprot id: P06767
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
messages: The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME).

10116:Prickle3
gene id: 10116:Prickle3
uniprot id: Q5U2Q0
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

10116:Amh
gene id: 10116:Amh
uniprot id: A6K8G0
uniprot id: P49000
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Mainly expressed in granulosa cells from preantral and small antral follicles.
messages: Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation and plays a role in Leydig cell differentiation and function (By similarity). In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression (By similarity).
messages: Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation and plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression.
messages: Preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active non-covalent complex. Binding of the non-covalent complex to AMHR2 induces dissociation of the pro-region from the mature C-terminal dimer. The N-terminal portion of the protein, despite having no intrinsic activity, has the role of amplifying the activity of the C-terminus.
messages: Secreted

10116:Sar1a
gene id: 10116:Sar1a
uniprot id: A0A8I5ZTV6
uniprot id: Q6AY18
names: Similarity
messages: Belongs to the small GTPase superfamily. SAR1 family.

10116:Stam
gene id: 10116:Stam
uniprot id: A0A0G2K9W6
uniprot id: B5DF55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

10116:Atp6v1c1
gene id: 10116:Atp6v1c1
uniprot id: A0A8I6GCD8
uniprot id: Q5FVI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the V-ATPase C subunit family.
messages: Expressed in brain (at protein level).
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32165585). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32165585). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (PubMed:32165585). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (PubMed:32165585). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (PubMed:32165585).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

10116:Btnl4
gene id: 10116:Btnl4
uniprot id: M0R4D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

10116:Pcdhgc5
gene id: 10116:Pcdhgc5
uniprot id: C6JUM5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

10116:Caprin1
gene id: 10116:Caprin1
uniprot id: Q5M9G3
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Ability to mediate liquid-liquid phase separation is regulated by ATP: moderate concentrations of ATP enhance phase separation, whereas high concentrations of ATP lead to inhibition of phase separation.
messages: Belongs to the caprin family.
messages: Cytoplasmic ribonucleoprotein granule
messages: Down-regulated by exposure to trichloroethylene (TCE) and dichloroethylene (DCE) in fetal heart.
messages: Expressed in hippocampal and neocortical pyramidal neurons, but not in Purkinje cells.
messages: May form homomultimers. Interacts with G3BP1; interaction is direct and promotes stress granule formation. Interacts with G3BP2; interaction is direct and promotes stress granule formation. Interacts with PQBP1. Interacts with DDX3X. Interacts (when phosphorylated by EPHA4) with FMR1; interaction with FMR1 promotes formation of a membraneless compartment.
messages: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. O-glycosylation by OGT inhibit ability to undergo liquid-liquid phase separation (LLPS).
messages: The C-terminal disordered region undergoes liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that concentrates mRNAs with associated regulatory factors. CAPRIN1 molecules in the condensed phase are neutral. mRNA-binding promotes phase separation. Moderate concentrations of ATP enhance phase separation by reducing the electrostatic potential of CAPRIN1, thereby promoting intermolecular interactions. In contrast, high concentrations of ATP invert the electrostatic potential of CAPRIN1, so that CAPRIN1 molecules become negatively charged, lead to inhibition of phase separation.
messages: Tyrosine phosphorylation by EPHA4 promotes interaction with FMR1 and liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that concentrates mRNAs with associated regulatory factors.
messages: cytosol
messages: dendrite
messages: lamellipodium
messages: mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:15858068, PubMed:20516077). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (By similarity). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (By similarity). Binds directly and selectively to MYC and CCND2 mRNAs (By similarity). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (By similarity).

10116:P2ry2
gene id: 10116:P2ry2
uniprot id: A6I6S6
uniprot id: G3V8H8
uniprot id: P41232
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

10116:Gpsm1
gene id: 10116:Gpsm1
uniprot id: A0A8I6AC91
uniprot id: A6JTD0
uniprot id: A6JTD2
uniprot id: G3V9X2
uniprot id: Q9R080
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the GPSM family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Expression reaches a maximum at postnatal day 7 before to significantly decrease.
messages: Golgi apparatus membrane
messages: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.
messages: Interacts with INSC/inscuteable and FRMPD1 (By similarity). Interacts with GNAI1, GNAI2 and GNAI3 preferentially in their GDP-bound state. May also interact with GNAO1. Interacts with STK11/LKB1 and MACF1.
messages: Isoform 4 is specifically expressed in brain by neurons and also detected in testis, liver, kidney, heart and pancreas (at protein level). Highly expressed in cerebellum and subventricular zone-olfactory bulb system. Isoform 2 and isoform 3 are specifically expressed in heart and are also detected in brain.
messages: Minor isoform. Mutagenesis of Met-1 into Gly leads to expression of isoform 2.
messages: Phosphorylation regulates interaction with G(i/o) alpha.
messages: Produced by alternative splicing.
messages: Produced by initiation at Met-62 of isoform 3. Mutagenesis of Met-1 into Gly prevents expression of this isoform. Combined mutagenesis of Gln-57, Gln-105 and Gln-129 into Ala alters the function of the GoLoco domains.
messages: Responsible for altered neurotransmission and altered behavior like drug seeking associated with cocaine addiction. Depletion in prefrontal cortex reverses the behavioral consequences of cocaine addiction while overexpression in drug-naive animals induces addictive behavior upon acute cocaine injection.
messages: The GoLoco domains mediate interaction with G(i/o) alpha. The GoLoco domains are essential for the GDI activity toward G(i/o) alpha.
messages: Up-regulated in prefrontal cortex and core region of nucleus accumbens during late withdrawal from chronic cocaine administration.
messages: cytosol

10116:Saxo2
gene id: 10116:Saxo2
uniprot id: A6JCK0
uniprot id: D3ZDP0
names: Similarity
messages: Belongs to the FAM154 family.

10116:Inpp5e
gene id: 10116:Inpp5e
uniprot id: Q9WVR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type IV family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi stack membrane
messages: Interacts (when prenylated) with PDE6D; this is important for normal location in cilia.
messages: Nucleus
messages: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate PtdIns (4,5)P2 and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Specific for lipid substrates, inactive towards water soluble inositol phosphates (By similarity) (PubMed:10405344). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity).
messages: cilium axoneme
messages: ruffle

10116:Vom2r52
gene id: 10116:Vom2r52
uniprot id: F1MAT0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Zbtb42
gene id: 10116:Zbtb42
uniprot id: B1WBS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily.
messages: Cytoplasm
messages: Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes.
messages: nucleoplasm

10116:Nos3
gene id: 10116:Nos3
uniprot id: Q62600
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Cell membrane
messages: Detected at high levels in lung during the late fetal and postnatal period and at lower levels in adult.
messages: Expressed constitutively by vascular endothelium. Detected in alveolar and serosal epithelial cells as well as in endothelial cells in one day old rat. In adult lung, detected in rare endothelial cells.
messages: Golgi apparatus
messages: Homodimer. Interacts with NOSIP and NOSTRIN (By similarity). Interacts with HSP90AB1 (By similarity). Forms a complex with ASL, ASS1 and SLC7A1; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway (By similarity).
messages: Phosphorylation by AMPK at Ser-1176 in the presence of Ca(2+)-calmodulin (CaM) activates activity. In absence of Ca(2+)-calmodulin, AMPK also phosphorylates Thr-494, resulting in inhibition of activity.
messages: Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
messages: Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN (By similarity).
messages: Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.
messages: caveola
messages: cytoskeleton

10116:Zfp414
gene id: 10116:Zfp414
uniprot id: Q5PPH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

10116:Rpl9
gene id: 10116:Rpl9
uniprot id: A6JDE3
uniprot id: P17077
uniprot id: Q6P9U5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

10116:Vstm5
gene id: 10116:Vstm5
uniprot id: A6JNB3
uniprot id: Q5M7U7
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Can homooligomerize through cis interactions within the same cell membrane.
messages: Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical development in the brain.
messages: Cell membrane
messages: Membrane
messages: N-glycosylated.
messages: axon
messages: dendrite

10116:Fa2h
gene id: 10116:Fa2h
uniprot id: Q2LAM0
names: Cofactor
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (Probable). FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids (By similarity). Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (PubMed:17901466). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (By similarity). Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (By similarity).
messages: Detected at low levels in sciatic nerve from newborns. Levels increase strongly during the first 3 weeks, and decrease thereafter to reach a low, constitutive level in 4 week olds. Expressed at a low, constitutive level in adults.
messages: Detected in oligodendrocytes (at protein level). Detected in sciatic nerve.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: The N-terminal cytochrome b5 heme-binding domain is essential for catalytic activity.
messages: The histidine box domains may contain the active site and/or be involved in metal ion binding.
messages: Up-regulated in sciatic nerve during myelination. Up-regulated in differentiating cultured Schwann cells.

10116:Cd163
gene id: 10116:Cd163
uniprot id: A0A0G2JVY2
uniprot id: A6ILI0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Atp5f1b
gene id: 10116:Atp5f1b
uniprot id: P10719
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Binds calcium ions.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL (PubMed:17575325). Interacts with PPIF (By similarity). Interacts with BCL2L1 isoform BCL-X(L); the interaction mediates the association of BCL2L1 isoform BCL-X(L) with the mitochondrial membrane F(1)F(0) ATP synthase and enhances neurons metabolic efficiency (PubMed:21926988). Interacts with CLN5 and PPT1 (By similarity). Interacts with S100A1; this interaction increases F1-ATPase activity (By similarity). Interacts with MTLN (By similarity). Interacts with TTC5/STRAP; the interaction results in decreased mitochondrial ATP production (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
messages: Mitochondrion inner membrane

10116:Dock9
gene id: 10116:Dock9
uniprot id: A0A8I6AKR0
uniprot id: A0A8I6AN54
uniprot id: F1LSM8
names: Similarity
messages: Belongs to the DOCK family.

10116:Cabin1
gene id: 10116:Cabin1
uniprot id: A0A1W2Q6J1
uniprot id: A6JKH7
uniprot id: O88480
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated through PKC-mediated hyperphosphorylation.
messages: Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1 (By similarity). Interacts with MEF2B (By similarity). Interacts with calcineurin.
messages: Cytoplasm
messages: May be required for replication-independent chromatin assembly (By similarity). May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin.
messages: Nucleus
messages: Widely expressed with prominent expression in neurons.

10116:Tas2r139
gene id: 10116:Tas2r139
uniprot id: A6IF63
uniprot id: Q67ER9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Putative taste receptor which may play a role in the perception of bitterness.
messages: Several bitter taste receptors are expressed in a single taste receptor cell.

10116:Xirp1
gene id: 10116:Xirp1
uniprot id: A0A8I5YBK9
uniprot id: D4ABA9
names: Domain
names: Function
names: Similarity
messages: Belongs to the Xin family.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

10116:Dhrs7b
gene id: 10116:Dhrs7b
uniprot id: A6HF59
uniprot id: A6HF61
uniprot id: Q5RJY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Endoplasmic reticulum membrane
messages: Putative oxidoreductase.

10116:Prkacb
gene id: 10116:Prkacb
uniprot id: A0A8I6A4F6
uniprot id: A0A8I6AV42
uniprot id: A6HWE9
uniprot id: A6HWF0
uniprot id: A6HWF1
uniprot id: A6HWF2
uniprot id: P68182
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Interacts with PRKAR1A and PRKAR2B (By similarity). The cAMP-dependent protein kinase catalytic subunit binds PJA2. Interacts with GPKOW.
messages: Activated by cAMP.
messages: Asn-3 is deaminated to Asp in more than 25% of the proteins, giving rise to 2 major isoelectric variants, called CB and CA respectively (0.4 pH unit change). Deamidation proceeds via the so-called beta-aspartyl shift mechanism and yields either 'D-Asp-2' (major) or 'D-isoAsp-2' (minor), in addition to L-isomers. Deamidation occurs after the addition of myristate. The Asn-3 form reaches a significantly larger nuclear/cytoplasmic ratio than the 'Asp-2' form.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR.
messages: Membrane
messages: Nucleus

10116:Pcp4
gene id: 10116:Pcp4
uniprot id: P63055
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the PCP4 family.
messages: Binds to both calcium-free and calcium-bound calmodulin. The affinity for the calcium-bound form is 50-fold greater.
messages: Detectable in the brain at embryonic day 17. The levels increase to reach a maximal value at postnatal day 18.
messages: Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls. For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways.
messages: Mostly intrinsically disordered, with residual structure localized to the IQ domain which mediates the interaction with calmodulin.
messages: Restricted to the nervous system. Expressed throughout the brain, in particular forebrain regions, including the granular layer of the olfactory bulb, and pyriform cortex. Also expressed in the hippocampus, caudate putamen and the cerebellum, where it is associated predominantly with Purkinje cells.

10116:Bpifb3
gene id: 10116:Bpifb3
uniprot id: A6KHX0
uniprot id: Q05701
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Highly expressed in olfactory mucosa but undetectable in thymus, kidney, lung, brain, spleen and liver.
messages: May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received.
messages: Secreted

10116:Trappc4
gene id: 10116:Trappc4
uniprot id: Q69BT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.
messages: Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12 (By similarity). Interacts with SDC2 (By similarity).
messages: Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (By similarity). May play a role in dendrite postsynaptic membrane trafficking (By similarity).
messages: Endoplasmic reticulum
messages: Golgi apparatus membrane
messages: Postsynaptic cell membrane
messages: Vesicle

10116:Katna1
gene id: 10116:Katna1
uniprot id: A6JP17
uniprot id: Q6E0V2
uniprot id: Z4YNM2
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit (By similarity). Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM (By similarity). Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42 (By similarity). Interacts with KATNB1 and KATNBL1 (By similarity).
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: spindle
messages: spindle pole

10116:Abi2
gene id: 10116:Abi2
uniprot id: O35823
names: Similarity
messages: Belongs to the ABI family.

10116:Krt81
gene id: 10116:Krt81
uniprot id: A7M775
uniprot id: Q6IG11
names: Similarity
messages: Belongs to the intermediate filament family.

10116:Actr10
gene id: 10116:Actr10
uniprot id: Q5M9F7
names: Similarity
messages: Belongs to the actin family.

10116:Vps45
gene id: 10116:Vps45
uniprot id: A6K348
uniprot id: O08700
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with STX6 and ZFYVE20.
messages: May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.
messages: Ubiquitous; expression was highest in testis and in brain. Detected in every part of the brain.

10116:Or2l5
gene id: 10116:Or2l5
uniprot id: A6JSD0
uniprot id: D3ZSQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Olr1065
gene id: 10116:Olr1065
uniprot id: D3ZIB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Zfp277
gene id: 10116:Zfp277
uniprot id: M0RDU3
names: Similarity
messages: Belongs to the ZNF277 family.

10116:Hsd17b12
gene id: 10116:Hsd17b12
uniprot id: Q6P7R8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
messages: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
messages: Endoplasmic reticulum membrane
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

10116:Slc6a3
gene id: 10116:Slc6a3
uniprot id: A6JUX6
uniprot id: P23977
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
messages: Brain (PubMed:1948034, PubMed:1765147). Expressed in the substantia nigra and ventral tegmental area, regions that contain dopaminergic cell bodies (PubMed:1765147).
messages: Cell membrane
messages: Homooligomer; disulfide-linked (By similarity). Interacts with PRKCABP and TGFB1I1 (By similarity). Interacts (via N-terminus) with SYNGR3 (via N-terminus) (By similarity). Interacts with SLC18A2 (By similarity). Interacts with TOR1A (ATP-bound); TOR1A regulates SLC6A3 subcellular location (By similarity). Interacts with alpha-synuclein/SNCA (By similarity). Interacts with SEPTIN4 (By similarity).
messages: Inhibited by mazindol, cocaine, desipramine, GBR 12783 dihydrochloride, GBR 12909 dihydrochloride and nomifensine.
messages: Mediates sodium- and chloride-dependent transport of dopamine (PubMed:1948035, PubMed:1948034, PubMed:1765147, PubMed:1502198, PubMed:8125921). Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (PubMed:8125921). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity).
messages: Membrane
messages: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.
messages: axon
messages: neuron projection

10116:Dld
gene id: 10116:Dld
uniprot id: A6HB44
uniprot id: Q6P6R2
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer. Part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (subunits PDHA (PDHA1 or PDHA2) and PDHB, E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules (by non covalent bonds). The 2-oxoglutarate dehydrogenase complex is composed of OGDH (2-oxoglutarate dehydrogenase; E1), DLST (dihydrolipoamide succinyltransferase; E2) and DLD (dihydrolipoamide dehydrogenase; E3). It contains multiple copies of the three enzymatic components (E1, E2 and E3). In the nucleus, the 2-oxoglutarate dehydrogenase complex associates with KAT2A. Interacts with PDHX.
messages: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease (By similarity). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity).
messages: Mitochondrion matrix
messages: Nucleus
messages: The active site is a redox-active disulfide bond.
messages: Tyrosine phosphorylated.
messages: acrosome
messages: flagellum

10116:Sptlc3
gene id: 10116:Sptlc3
uniprot id: A6HQL6
uniprot id: D4A9V0
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

10116:Or5af1b
gene id: 10116:Or5af1b
uniprot id: A0A8I6AAA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Lpxn
gene id: 10116:Lpxn
uniprot id: Q5M852
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: Cell membrane
messages: Cytoplasm
messages: Nucleus
messages: The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR.
messages: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN).
messages: focal adhesion
messages: perinuclear region
messages: podosome

10116:Atp6v1g3
gene id: 10116:Atp6v1g3
uniprot id: A6ICK6
uniprot id: D3ZTZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

10116:Tnfaip2
gene id: 10116:Tnfaip2
uniprot id: A6KBR0
names: Similarity
messages: Belongs to the SEC6 family.

10116:Sike1
gene id: 10116:Sike1
uniprot id: A6K3J8
uniprot id: Q5FWT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIKE family.
messages: Cytoplasm
messages: Interacts with IKBKE and TBK1 via its coiled coil region. Interaction with TBK1 is disrupted upon viral infection or TLR3 stimulation. Interacts with CDC42BPB.
messages: Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways (By similarity).

10116:Pop5
gene id: 10116:Pop5
uniprot id: A6J1W0
uniprot id: D3ZY31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

10116:Cmtm1
gene id: 10116:Cmtm1
uniprot id: Q4QQS9
names: Subcellular Location Annotation
messages: Membrane

10116:Cd53
gene id: 10116:Cd53
uniprot id: A6HUR6
uniprot id: P24485
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell junction
messages: Cell membrane
messages: Interacts with SCIMP.
messages: Membrane
messages: Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).
messages: Spleen and thymus, B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes, peripheral T-cells.

10116:Awat1
gene id: 10116:Awat1
uniprot id: A6IQ77
uniprot id: D3ZVA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

10116:Krt71
gene id: 10116:Krt71
uniprot id: A6KCR3
uniprot id: U3R784
names: Similarity
messages: Belongs to the intermediate filament family.

10116:Eml6
gene id: 10116:Eml6
uniprot id: D3ZQR6
names: Function
names: Similarity
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

10116:Vom2r69
gene id: 10116:Vom2r69
uniprot id: D3ZXT3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Rtfdc1
gene id: 10116:Rtfdc1
uniprot id: Q3T1J8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the rtf2 family.
messages: Chromosome
messages: Interacts with DDI2; probably also interacts with DDI1.
messages: Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA.
messages: Undergoes proteasomal degradation, via DDI1 and DDI2. Removal from stalled replisomes and degradation are required for genome stability.

10116:Tsc22d4
gene id: 10116:Tsc22d4
uniprot id: Q3B8N7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TSC-22/Dip/Bun family.
messages: Binds DNA and acts as a transcriptional repressor (By similarity). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (By similarity). May play a role in neurite elongation and survival (By similarity).
messages: Cytoplasm
messages: Forms a homodimer or heterodimer (By similarity). Forms a heterodimer with TSC22D1 isoforms 1 and 2 (By similarity). Interacts with NRBP1 (By similarity).
messages: Nucleus
messages: Synapse
messages: dendrite

10116:Ppp4r3a
gene id: 10116:Ppp4r3a
uniprot id: A0A8I6AS21
uniprot id: A6JEI6
names: Similarity
messages: Belongs to the SMEK family.

10116:Uqcrh
gene id: 10116:Uqcrh
uniprot id: A6JZ59
uniprot id: Q5M9I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Mitochondrion inner membrane

10116:Dnpep
gene id: 10116:Dnpep
uniprot id: A0A8I6A8L3
uniprot id: A0A8I6ABE2
uniprot id: A6JW17
uniprot id: A6JW18
uniprot id: Q4V8H5
names: Similarity
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Tetrahedron-shaped homododecamer built from six homodimers.

10116:Olr1253
gene id: 10116:Olr1253
uniprot id: D3ZI10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Prpf31
gene id: 10116:Prpf31
uniprot id: A0A8I6GLQ3
uniprot id: A6KS26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Cajal body

10116:Serpinb6b
gene id: 10116:Serpinb6b
uniprot id: A0A9K3Y788
uniprot id: Q68FX2
names: Similarity
messages: Belongs to the serpin family.

10116:Artn
gene id: 10116:Artn
uniprot id: A6JZG2
uniprot id: Q6AYE8
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Cochlea. Expressed at higher level in sesorineural epithelium than in the modiolus region or substantia nigra.
messages: Expressed during embryogenesis. At 14 dpc, not detected in the brain or spinal cord. A striking expression seen in the nerve roots but not in the developing neurons of the dorsal root ganglia. A significant expression also seen around the superior mesentric artery.
messages: Homodimer; disulfide-linked. Binds to RET (By similarity).
messages: Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity).
messages: Secreted

10116:Cfap119
gene id: 10116:Cfap119
uniprot id: B0BMZ6
names: Developmental Stage
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expression is detected at 3 weeks of postnatal development and persists up to adulthood (PubMed:27032685). Expressed in elongated spermatids but not detected in spermatogonia, spermatocytes, and round spermatids (PubMed:27032685).
messages: Specifically expressed in testis (at protein level).
messages: acrosome
messages: flagellum

10116:Mmp20
gene id: 10116:Mmp20
uniprot id: A6JN38
uniprot id: D3ZXD9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

10116:Zc3hc1
gene id: 10116:Zc3hc1
uniprot id: B2RYM6
names: Subcellular Location Annotation
messages: Nucleus

10116:B3gnt4
gene id: 10116:B3gnt4
uniprot id: A6J146
uniprot id: D4A3H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

10116:Olr1293
gene id: 10116:Olr1293
uniprot id: M0R8G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tomm7
gene id: 10116:Tomm7
uniprot id: D3ZMR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

10116:Dgkb
gene id: 10116:Dgkb
uniprot id: P49621
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by calcium.
messages: Belongs to the eukaryotic diacylglycerol kinase family.
messages: Cell membrane
messages: Cytoplasm
messages: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:7689223, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (PubMed:7689223). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity).
messages: Highly expressed in brain where it is restricted to neuronal populations such as the caudate-putamen, the accumbens nucleus, and the olfactory tubercle (PubMed:7689223). Less abundantly expressed in adrenal gland, small intestine and heart (PubMed:7689223).
messages: Postsynaptic cell membrane

10116:Fut7
gene id: 10116:Fut7
uniprot id: Q712G6
names: Activity Regulation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 10 family.
messages: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein or a glycolipid-linked sialopolylactosamines chain through an alpha-1,3 glycosidic linkage and participates in the final fucosylation step in the biosynthesis of the sialyl Lewis X (sLe(x)), a carbohydrate involved in cell and matrix adhesion during leukocyte trafficking and fertilization (PubMed:16218937). In vitro, also synthesizes sialyl-dimeric-Lex structures, from VIM-2 structures and both di-fucosylated and trifucosylated structures from mono-fucosylated precursors. However does not catalyze alpha 1-3 fucosylation when an internal alpha 1-3 fucosylation is present in polylactosamine chain and the fucosylation rate of the internal GlcNAc residues is reduced once fucose has been added to the distal GlcNAc. Also catalyzes the transfer of a fucose from GDP-beta-fucose to the 6-sulfated a(2,3)sialylated substrate to produce 6-sulfo sLex mediating significant L-selectin-dependent cell adhesion. Through sialyl-Lewis(x) biosynthesis, can control SELE- and SELP-mediated cell adhesion with leukocytes and allows leukocytes tethering and rolling along the endothelial tissue thereby enabling the leukocytes to accumulate at a site of inflammation. May enhance embryo implantation through sialyl Lewis X (sLeX)-mediated adhesion of embryo cells to endometrium. May affect insulin signaling by up-regulating the phosphorylation and expression of some signaling molecules involved in the insulin-signaling pathway through SLe(x) which is present on the glycans of the INSRR alpha subunit (By similarity).
messages: Expressed in lymph node and kidney.
messages: Golgi stack membrane
messages: Inhibited by NaCl. Inhibited by GDP in a concentration dependent manner, with an IC(50) value of 93 uM. Also inhibited by GMP and GTP. Inhibited by N-ethylmaleimide. Activated by poly(ethylene glycol) by enhancing the thermal stability of FUT7. Activated by Mn2+, Ca2+, and Mg2+. Both panosialin A and B inhibit activity with IC(50) values of 4.8 and 5.3 ug/ml, respectively. Inhibited by gallic acid (GA) and (-)-epigallocatechin gallate (EGCG) in a time-dependent and irreversible manner with IC(50) values of 60 and 700 nM, respectively.
messages: N-glycosylated.
messages: Strongly induced in kidney allograft during rejection.

10116:Aif1l
gene id: 10116:Aif1l
uniprot id: A6JU37
names: Subcellular Location Annotation
messages: ruffle membrane

10116:Anks6
gene id: 10116:Anks6
uniprot id: P0C0T2
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Defects in Anks6 are the cause of polycystic kidney disease (cy). Heterozygous cy rats are characterized by progressive formation and enlargement of cysts in kidneys.
messages: Homooligomer (PubMed:19324013). Central component of a complex containing at least ANKS6, INVS, NEK8 and NPHP3 (PubMed:23793029). ANKS6 may organize complex assembly by linking INVS and NPHP3 to NEK8 and INVS may target the complex to the proximal ciliary axoneme (PubMed:23793029). Interacts (via SAM domain) with BICC1 (via KH domains) in an RNA-dependent manner (PubMed:19324013). Interacts (via SAM domain) with ANKS3 (via SAM domain) (PubMed:25671767, PubMed:26327442, PubMed:26188091).
messages: Hydroxylated at Asn-129, most probably by HIF1AN. This hydroxylation results in decreased NEK8-binding.
messages: Required for renal function.
messages: The ankyrin repeats are necessary and sufficient for NEK8-binding.
messages: Widely expressed with moderate level in brain, skeletal muscle and testis. Expressed in renal tubules.
messages: cilium

10116:Calhm4
gene id: 10116:Calhm4
uniprot id: D3ZDN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

10116:Msh2
gene id: 10116:Msh2
uniprot id: F7FQ51
uniprot id: P54275
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family.
messages: Chromosome
messages: Component of the DNA mismatch repair (MMR) complex composed at least of MCM9, MCM8,MSH2, MSH3, MSH6, PMS1 and MLH1. Heterodimer consisting of MSH2-MSH6 (MutS alpha) or MSH2-MSH3 (MutS beta). Both heterodimers form a ternary complex with MutL alpha (MLH1-PMS1). Interacts with MCM9; the interaction recruits MCM9 to chromatin. Interacts with MCM8. Interacts with EXO1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with ATR. Interacts with SLX4/BTBD12; this interaction is direct and links MutS beta to SLX4, a subunit of different structure-specific endonucleases. Interacts with SMARCAD1.
messages: Component of the post-replicative DNA mismatch repair system (MMR).
messages: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
messages: Nucleus

10116:Col10a1
gene id: 10116:Col10a1
uniprot id: A0A0G2K7A5
names: Subcellular Location Annotation
messages: Secreted

10116:Ackr3
gene id: 10116:Ackr3
uniprot id: O89039
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1 (By similarity). Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway (PubMed:20018651). Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels (By similarity).
messages: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development.
messages: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
messages: By ischemia. Up-regulated in the cingulate, retrosplenial and frontal areas of the cortex ipsilateral to middle cerebral artery occlusion (MCAO) by 163% at 6 hours, 220% at 2 days and 89% at 4 days after ischemia-onset, with expression reduced back to control level at 10 days after MCAO. Expression is almost undetectable in the infarct area between days 2 and 10 after MCAO.
messages: Cell membrane
messages: Early endosome
messages: Expressed in the ventral and dorsal parts of telencephalon at all developmental stages of brain analyzed (14 dpc to P56). Strong expression detected in the cranial connective tissue surrounding the brain at 14 dpc to 15 dpc. In the cortex, expressed mainly in the marginal zone at preplate stage (14 dpc), with expression increasing strongly in the marginal zone/layer I between 15 dpc and 18 dpc and declining rapidly in layer I after P0. Expression emerges in the lateral part of cortical plate at 15 dpc and increases in the medial and lateral parts between 15 dpc and 17 dpc. Expression not detected in the cortical ventricular and subventricular zones at the early embryonic stages but emerges at 18 dpc. Expressed in GABAergic precursors and in some reelin-expressing Cajal-Ratzius cells, in neurons forming the cortical plate and sparsely in the developing dentate gyrus and cerebellar external germinal layer. In the ventral telencephalon, expressed in the germinative zone of the ganglionic eminences and in GABAergic neurons forming the caudate putamen between 14 dpc and 18 dpc.
messages: Expressed in vascular smooth muscle cells (at protein level). In brain, expressed in blood vessels, pyramidal cells in hippocampal subfield CA3, mature dentate gyrus granule cells, ventricle walls, olfactory bulb, accumbens shell, supraoptic, lateroanterior and ventromedial hypothalamic nuclei, medial region of thalamus, and motor nuclei, central gray and raphe magnus nucleus of brain stem. Detected in primary neurons, GABAergic neurons, astrocytes, cerebral cortex, ventral striatum and choroid plexus. Not detected in mesencephalon.
messages: Homodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity. Interacts with ARRB1 and ARRB2.
messages: Recycling endosome
messages: The C-terminal cytoplasmic tail, plays a key role in: correct trafficking to the cell membrane, recruitment of beta-arrestin, ubiquitination, and in chemokine scavenging and signaling functions. The Ser/Thr residues and the Lys residues in the C-terminal cytoplasmic tail are essential for beta-arrestin recruitment and ubiquitination respectively.
messages: The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated.
messages: Ubiquitinated at the Lys residues in its C-terminal cytoplasmic tail and is essential for correct trafficking from and to the cell membrane. Deubiquitinated by CXCL12-stimulation in a reversible manner.

10116:Tenm4
gene id: 10116:Tenm4
uniprot id: F1LZ38
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Klc1
gene id: 10116:Klc1
uniprot id: A0A140TAB3
uniprot id: A0A8L2QTG3
uniprot id: P37285
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the kinesin light chain family.
messages: Cytoplasmic vesicle
messages: Expressed in brain (at protein level).
messages: It is uncertain whether Met-1 or Met-5 is the initiator.
messages: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (PubMed:19861499). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (PubMed:19861499).
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains (Probable). Interacts with SPAG9 (By similarity). Interacts with ATCAY; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections (PubMed:19861499). Interacts (via TPR repeats) with TOR1A; the interaction associates TOR1A with the kinesin oligomeric complex (PubMed:14970196). Interacts with BORCS5 (By similarity). Interacts with MAPK8IP3/JIP3 and NTRK2/TRKB; interaction with NTRK2/TRKB is mediated by MAPK8IP3/JIP3 (PubMed:21775604). Interacts with CLSTN1; phosphorylation at Ser-460 inhibits interaction with CLSTN1 (By similarity).
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: Phosphorylation at Ser-460 by ERK inhibits interaction with CLSTN1 and localization to cytoplasmic vesicles.
messages: cytoskeleton
messages: growth cone

10116:Amt
gene id: 10116:Amt
uniprot id: Q5XI85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

10116:Calhm6
gene id: 10116:Calhm6
uniprot id: A6K3S8
uniprot id: Q561R8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane
messages: Pore-forming subunit of a voltage-gated ion channel.

10116:Ska1
gene id: 10116:Ska1
uniprot id: B0BN28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SKA1 family.
messages: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. In the complex, it mediates the interaction with microtubules.
messages: Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3. Forms a heterodimer with SKA2; the heterodimer interacting with SKA3. The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each heterodimer interacting with a molecule of the SKA3 homodimer. The core SKA1 complex associates with microtubules and forms oligomeric assemblies. Interacts with microtubules; the interaction is direct. Interacts with SKA2. Interacts with SKA3.
messages: kinetochore
messages: spindle

10116:Polb
gene id: 10116:Polb
uniprot id: A6IW62
uniprot id: P06766
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-X family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.
messages: Monomer (By similarity). Binds single-stranded DNA (ssDNA) (By similarity). Interacts with APEX1, LIG1, LIG3, FEN1, PCNA and XRCC1 (By similarity). Interacts with HUWE1/ARF-BP1, STUB1/CHIP and USP47 (By similarity). Interacts with FAM168A (By similarity).
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase.
messages: Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity.
messages: Ubiquitinated at Lys-41, Lys-61 and Lys-81: monoubiquitinated by HUWE1/ARF-BP1. Monoubiquitinated protein is then the target of STUB1/CHIP, which catalyzes polyubiquitination from monoubiquitin, leading to degradation by the proteasome. USP47 mediates the deubiquitination of monoubiquitinated protein, preventing polyubiquitination by STUB1/CHIP and its subsequent degradation (By similarity).

10116:Npepl1
gene id: 10116:Npepl1
uniprot id: A6KL20
names: Similarity
messages: Belongs to the peptidase M17 family.

10116:Cd27
gene id: 10116:Cd27
uniprot id: Q501W2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Slc7a8
gene id: 10116:Slc7a8
uniprot id: A6KGW1
uniprot id: Q9WVR6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Associates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1 (PubMed:10391916). Functions as amino acid antiporter mediating the influx of extracellular essential amino acids mainly in exchange with the efflux of highly concentrated intracellular amino acids. Has relatively symmetrical selectivities but strongly asymmetrical substrate affinities at both the intracellular and extracellular sides of the transporter. This asymmetry allows SLC7A8 to regulate intracellular amino acid pools (mM concentrations) by exchange with external amino acids (uM concentration range), equilibrating the relative concentrations of different amino acids across the plasma membrane instead of mediating their net uptake. May play an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (By similarity). Imports the thyroid hormone diiodothyronine (T2) and to a smaller extent triiodothyronine (T3) but not rT 3 or thyroxine (T4) (By similarity). Mediates the uptake of L-DOPA (PubMed:15200428). May participate in auditory function (By similarity).
messages: Basolateral cell membrane
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Disulfide-linked heterodimer composed of the catalytic light chain subunit SLC7A8 and the heavy chain subunit SLC3A2 (PubMed:10391916). SLC3A2 acts as chaperones for correct plasma membrane trafficking and stabilization of SLC7A8 and modulates the substrate affinity and specificity of SLC7A8. ICAM-1 associates with the heterodimer SLC3A2/SLC7A8; facilitates leucine uptake (By similarity).
messages: Expression is seen in jejunum mucosa and the epithelial cells of the jejunum, ileum and colon, as well as in kidney, placenta, brain, testis and skeletal muscle. Expressed in retina, inner blood-retinal barrier of retina, retinal vascular endothelial cells. Also expressed in the intestinal epithelial cell line IEC-6 and in the retinal capillary endothelial cell line TR-iBRB2.
messages: Leucine transport activity is inhibited by 2-amino-bicyclo-(2,2,1)-heptane-2-carboxylate (BCH), glycine, L-isomers of the neutral amino acids and histidine.
messages: Membrane

10116:Tnpo2
gene id: 10116:Tnpo2
uniprot id: A6IY37
uniprot id: D3ZER6
names: Subcellular Location Annotation
messages: Cytoplasm

10116:Fignl1
gene id: 10116:Fignl1
uniprot id: A6KJB2
uniprot id: Q6GX84
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: By E2F1 and serum stimulation.
messages: Cytoplasm
messages: Hexamer. Interacts (via N-terminal one-half region) with RAD51; the interaction is direct. Interacts (via N-terminal one-half region) with SPIDR (via the C-terminal region); the interaction is direct (By similarity). Interacts with FIRRM; may regulate homologous recombination (By similarity).
messages: Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (By similarity). May play a role in the control of male meiosis dynamic (By similarity).
messages: Nucleus
messages: The N-terminus is necessary for its recruitment to DNA damage sites.
messages: perinuclear region

10116:Ugt1a6
gene id: 10116:Ugt1a6
uniprot id: F7FJM7
uniprot id: P08430
uniprot id: Q63662
uniprot id: Q6T5E9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome
messages: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

10116:Or1o11b
gene id: 10116:Or1o11b
uniprot id: A0A8I6A8T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ythdf2
gene id: 10116:Ythdf2
uniprot id: B2GUU1
uniprot id: Q1JU70
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

10116:Rhag
gene id: 10116:Rhag
uniprot id: Q7TNK7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Heterotrimer with RHCE (RHAG)2(RHCE), that transports ammonium and its related derivative methylammonium, in both neutral and ionic forms, across the erythrocyte membrane. The transport of NH4(+) is electrogenic and masks the NH3 transport. Also, may act as a CO2 channel. Moreover in erythrocyte, regulates RHD membrane expression and is associated with rhesus blood group antigen expression.
messages: Glycosylated.
messages: Homodimer. Heterotrimer; a RHCE monomer interacts with a RHAG homodimer. Component of the ankyrin-1 complex in the erythrocyte, composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1. Interacts with GYPB (via the N-terminal); this interaction bridges the (RHAG)2(RHCE) heterotrimer with the SLC4A1 Band 3 I dimer complexed with GYPA.
messages: Membrane

10116:Phc3
gene id: 10116:Phc3
uniprot id: A0A0G2K2B0
uniprot id: A6IHK6
names: Subcellular Location Annotation
messages: Nucleus

10116:Cpne9
gene id: 10116:Cpne9
uniprot id: Q5BJS7
names: Function
names: Similarity
messages: Belongs to the copine family.
messages: Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Plays a role in dendrite formation by melanocytes.

10116:Nol6
gene id: 10116:Nol6
uniprot id: A0A0G2QC27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: nucleolus

10116:Slc15a2
gene id: 10116:Slc15a2
uniprot id: A0A0H2UHA7
uniprot id: A6IRB4
uniprot id: Q5U401
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

10116:Dnajc8
gene id: 10116:Dnajc8
uniprot id: Q642C0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with SRPK1. Interacts with HSP70 (HSPA1A or HSPA1B).
messages: Nucleus
messages: Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells.

10116:Olr1454
gene id: 10116:Olr1454
uniprot id: A0A8I5ZZJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Cacybp
gene id: 10116:Cacybp
uniprot id: A6ID58
uniprot id: A6ID59
uniprot id: Q6AYK6
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1 (By similarity). Interacts with protein of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner.
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity).
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus
messages: Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations (By similarity).

10116:Gucy2d
gene id: 10116:Gucy2d
uniprot id: A6HFP3
uniprot id: P51840
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by GUCA1A when free calcium ions concentration is low, and inhibited by GUCA1A when free calcium ions concentration is high (By similarity). Negatively regulated by RD3; inhibits the basal and GUCA1A-stimulated guanylate cyclase activity (By similarity).
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane.
messages: Endoplasmic reticulum membrane
messages: Expressed in retina and enriched in photoreceptor outer segments.
messages: Homodimer; requires homodimerization for guanylyl cyclase activity (PubMed:9153227). Interacts (via C-terminus) with RD3 (via C-terminus); promotes the exit of GUCY2E from the endoplasmic reticulum and its trafficking to the photoreceptor outer segments (By similarity). Interaction with RD3 negatively regulates GUCY2E guanylate cyclase activity (By similarity).
messages: Membrane
messages: Photoreceptor outer segment membrane
messages: There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.

10116:Vgll2
gene id: 10116:Vgll2
uniprot id: A6K475
uniprot id: D3ZG38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

10116:Vps29
gene id: 10116:Vps29
uniprot id: B2RZ78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Acts also as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27.
messages: Belongs to the VPS29 family.
messages: Component of the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35 (By similarity). The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform (By similarity). The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described retromer complex (also called SNX-BAR retromer) is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX-BAR subcomplex to form the SNX27-retromer complex. Component of the heterotrimeric retriever complex formed by VPS26C, VPS29 and VPS35L. Interacts with VPS35L (By similarity). Interacts with VPS26A, VPS35, SNX1, SNX2, SNX27, WASHC5, TBC1D5 (By similarity). Interacts with VPS26B and ANKRD27 (By similarity).
messages: Cytoplasm
messages: Early endosome
messages: Endosome membrane
messages: Late endosome
messages: Membrane

10116:Uba2
gene id: 10116:Uba2
uniprot id: B1WC32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.
messages: Nucleus
messages: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

10116:Nkapl
gene id: 10116:Nkapl
uniprot id: Q4QR70
names: Similarity
messages: Belongs to the NKAP family.

10116:Vom2r44
gene id: 10116:Vom2r44
uniprot id: A6JVP8
uniprot id: F1LQ12
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Gpr139
gene id: 10116:Gpr139
uniprot id: A0A142CHG5
uniprot id: P0C0W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Orphan receptor. Seems to act through a G(q/11)-mediated pathway.

10116:Txndc5
gene id: 10116:Txndc5
uniprot id: A6J7A3
uniprot id: D3ZZC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

10116:Vegfa
gene id: 10116:Vegfa
uniprot id: A6JIU4
uniprot id: A6JIU7
uniprot id: A6JIV1
uniprot id: A6JIV5
uniprot id: A6JIV9
uniprot id: A6JIW0
uniprot id: B5DEK7
uniprot id: P16612
uniprot id: Q541S7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Expressed in the pituitary, in brain, in particularly in supraoptic and paraventricular nuclei and the choroid plexus. Also found abundantly in the corpus luteum of the ovary and in kidney glomeruli. Expressed in the ductal epithelial cells of post-pubertal mammary glands. Expressed in the ductal and alveolar epithelial cells throughout the whole period of gestational evolution, lactation and involution.
messages: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
messages: Homodimer; disulfide-linked (PubMed:7706320). Also found as heterodimer with PGF (PubMed:7706320). Interacts with NRP1 (By similarity). Interacts with isoform 2 of BSG (By similarity).
messages: Increases during pregnancy (5.0-fold increase on day 12 with a subsequent decrease on day 18) and during lactation (18.5-fold increase on day 7). Levels appear to be minimally altered during involution.
messages: Secreted

10116:Stfa2l1
gene id: 10116:Stfa2l1
uniprot id: A0A9K3Y852
uniprot id: Q6IE17
names: Similarity
messages: Belongs to the cystatin family.

10116:LOC681385
gene id: 10116:LOC681385
uniprot id: A0A8I5ZQ99
uniprot id: A6JTH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

10116:Mospd3
gene id: 10116:Mospd3
uniprot id: A6J017
uniprot id: F7F0P6
names: Subcellular Location Annotation
messages: Membrane

10116:Myrf
gene id: 10116:Myrf
uniprot id: A0A8I6AIU7
uniprot id: D4A352
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRF family.
messages: Membrane

10116:Pltp
gene id: 10116:Pltp
uniprot id: E9PSP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Secreted

10116:Pcgf1
gene id: 10116:Pcgf1
uniprot id: Q6DLV9
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells.
messages: Highly expressed in brain, cerebellum, heart and testis.
messages: Interacts with BCORL1, forming heterodimers (By similarity). The PCGF1-BCORL1 heterodimeric complex interacts with the KDM2B-SKP1 heterodimeric complex to form a homotetrameric polycomb repression complex 1 (PRC1.1) (By similarity). Component of the repressive BCOR complex containing a Polycomb group subcomplex at least composed of RYBP, RING1 and RNF2/RING2 (By similarity). Specifically interacts with BCOR, RING1 and RNF2/RING2 (By similarity). Component of a PRC1-like complex (By similarity). Interacts with CBX6, CBX7 and CBX8 (By similarity). Interacts with DPPA4, NANOG, POU5F1 and RYBP (By similarity).
messages: Nucleus

10116:Prph2
gene id: 10116:Prph2
uniprot id: A6JIL5
uniprot id: P17438
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PRPH2/ROM1 family.
messages: Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity).
messages: Homodimer; disulfide-linked (By similarity). Forms a homotetramer (By similarity). Forms a heterotetramer with ROM1 (By similarity). Homotetramer and heterotetramer core complexes go on to form higher order complexes by formation of intermolecular disulfide bonds (By similarity). Interacts with MREG (By similarity). Interacts with STX3 (By similarity). Interacts with SNAP25 (By similarity).
messages: Membrane
messages: Photoreceptor inner segment
messages: Retina (photoreceptor). In rim region of ROS (rod outer segment) disks.
messages: photoreceptor outer segment

10116:Or5m13b
gene id: 10116:Or5m13b
uniprot id: A6HMV6
uniprot id: D3Z9W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tpst2
gene id: 10116:Tpst2
uniprot id: A0A8L2PYI1
uniprot id: A6J265
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

10116:Or13a19
gene id: 10116:Or13a19
uniprot id: A0A8I6AE87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tekt1
gene id: 10116:Tekt1
uniprot id: A6HGF1
uniprot id: Q99JD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tektin family.
messages: Interacts with TEKT3.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: Predominantly expressed in testis.
messages: cilium axoneme
messages: flagellum
messages: flagellum axoneme

10116:Krtap13-2
gene id: 10116:Krtap13-2
uniprot id: A0A8I6A9J8
uniprot id: A6JLA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

10116:Cubn
gene id: 10116:Cubn
uniprot id: O70244
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.
messages: Endosome membrane
messages: Expressed at 6 dpc in primitive endoderm cells, in apical membrane invaginations, in endocytic vesicles, endoplasmic reticulum and Golgi apparatus. At the egg cylinder stage (7-8 dpc), expressed in visceral and parietal endoderm. From the early headfold stage (8.9 dpc), expressed in ectodermal cells lining the proamniotic cavity. At 10 dpc, detected in the newly forming neuroepithelium.
messages: Expressed to intestinal, renal and yalk sac apical membranes. In kidney, expressed in the proximal tubule.
messages: Interacts with AMN (PubMed:14576052, PubMed:29402915). Component of the cubam complex composed of one CUBN trimer and one AMN chain (By similarity). The cubam complex can dimerize (By similarity). Interacts with LRP2 in a dual-receptor complex in a calcium-dependent manner (PubMed:9478979). Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with LRP1 and PID1/PCLI1 (PubMed:20237569) (By similarity).
messages: Lysosome membrane
messages: N-glycosylated.
messages: The CUB domains 5 to 8 mediate binding to CBLIF and ALB. CUB domains 1 and 2 mediate interaction with LRP2.
messages: The cubam complex is composed of a 400 Angstrom long stem and a globular crown region. The stem region is probably formed by AMN and the CUBN N-terminal region, including the EGF-like domains. The crown is probably formed by the CUBN CUB domains.
messages: The precursor is cleaved by a trans-Golgi proteinase furin, removing a propeptide.

10116:Izumo1r
gene id: 10116:Izumo1r
uniprot id: A6JNA9
uniprot id: F1M928
names: Similarity
messages: Belongs to the folate receptor family.

10116:Or10a4
gene id: 10116:Or10a4
uniprot id: A6I7R1
uniprot id: F1M571
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tas1r3
gene id: 10116:Tas1r3
uniprot id: A6IUT6
uniprot id: Q923K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
messages: Cell membrane
messages: Forms homodimers or heterodimers with TAS1R1 and TAS1R2.
messages: Membrane
messages: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (By similarity).

10116:Nmt1
gene id: 10116:Nmt1
uniprot id: A6HJP2
uniprot id: Q8K1Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3'. Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle.
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.
messages: Cytoplasm
messages: Membrane
messages: cytosol

10116:Nptx1
gene id: 10116:Nptx1
uniprot id: A6HL92
uniprot id: P47971
names: Caution
names: Cofactor
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds 2 calcium ions per subunit.
messages: Cerebellum, hippocampus and cerebral cortex.
messages: Endoplasmic reticulum
messages: Glycosylated.
messages: Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.
messages: Secreted
messages: secretory vesicle

10116:Moxd2
gene id: 10116:Moxd2
uniprot id: A6IEZ3
uniprot id: D3Z830
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

10116:Smg5
gene id: 10116:Smg5
uniprot id: E9PU03
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay.

10116:Slc44a5
gene id: 10116:Slc44a5
uniprot id: A6HWP8
uniprot id: D3Z9P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

10116:Camk2a
gene id: 10116:Camk2a
uniprot id: A6IXE8
uniprot id: P11275
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-286 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
messages: Autophosphorylation of Thr-286 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-286 locks the kinase into an activated state.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
messages: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (PubMed:15312654). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (By similarity). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (By similarity). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity).
messages: Palmitoylated (PubMed:23687301). Probably palmitoylated by ZDHHC3 and ZDHHC7 (PubMed:23687301).
messages: Postsynaptic density
messages: Synapse
messages: There are 4 genes encoding calcium/calmodulin-dependent protein kinase type II chains: CAMK2A, CAMK2B, CAMK2G and CAMK2D. The corresponding proteins assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other (By similarity). Interacts with BAALC (PubMed:15659234). Interacts with MPDZ (PubMed:15312654). Interacts with SYN1 (PubMed:1328883). Interacts with CAMK2N2 (PubMed:9724800). Interacts with SYNGAP1 (PubMed:15312654). Interacts with SYNPO2 (PubMed:17923693). Interacts with SHANK3. Interacts with GRIN2B. Interacts with CACNB2. Interacts with LRRC7. Interacts with GRM5 (By similarity). Interacts with DAGLA (via C-terminal); this interaction is enhanced by autophosphorylation of CAMK2A at Thr-286 (By similarity). Interacts with CAMK2N1; this interaction requires CAMK2A activation by Ca(2+) (PubMed:11182241).
messages: dendrite
messages: dendritic spine

10116:Bcat1
gene id: 10116:Bcat1
uniprot id: A0A0G2K7K5
uniprot id: A0A8I5ZVC5
uniprot id: A6IMZ1
uniprot id: A6IMZ4
uniprot id: P54690
uniprot id: Q99JD5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
messages: Brain, low expression in ovary and placenta, but not found in liver, kidney, and skeletal muscle.
messages: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
messages: Cytoplasm
messages: Homodimer.
messages: The N-terminus is blocked.

10116:Ccdc153
gene id: 10116:Ccdc153
uniprot id: Q5FVL4
names: Similarity
messages: Belongs to the UPF0610 family.

10116:Areg
gene id: 10116:Areg
uniprot id: A6KKC9
uniprot id: P24338
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amphiregulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
messages: Membrane
messages: The immature precursor interacts with CNIH.

10116:Vwc2
gene id: 10116:Vwc2
uniprot id: A6KJ97
uniprot id: M0RB53
names: Subcellular Location Annotation
messages: Synapse

10116:Or4k15
gene id: 10116:Or4k15
uniprot id: A0A8I6AQJ4
uniprot id: A6KE92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ano7
gene id: 10116:Ano7
uniprot id: Q6IFT6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity). May play a role in cell-cell interactions (By similarity).
messages: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

10116:Paqr3
gene id: 10116:Paqr3
uniprot id: A6K658
uniprot id: F7ELC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

10116:Adamts7
gene id: 10116:Adamts7
uniprot id: A0A140TAF3
uniprot id: Q1EHB3
names: Caution
names: Cofactor
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Detected in liver, ovary, kidney, testicle, lung and embryo.
messages: Glycosylated (By similarity). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion. O-glycosylated proteoglycan. Contains chondroitin sulfate (By similarity).
messages: Interacts with COMP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be cleaved by a furin endopeptidase. The precursor is sequentially processed (By similarity).
messages: Metalloprotease that may play a role in the degradation of COMP.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme (By similarity).
messages: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
messages: extracellular matrix

10116:Csnk1g2
gene id: 10116:Csnk1g2
uniprot id: A0A0H2UHQ2
uniprot id: A6K8I3
uniprot id: A6K8I6
uniprot id: Q62762
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated (PubMed:7759525). Phosphorylated by aPKC which promotes dissociation from the cell cortex (By similarity).
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
messages: Cytoplasm
messages: Monomer (By similarity). Interacts with MTA1 (short isoform) in the cytoplasm (By similarity). Interacts with SMAD3 (By similarity). Interacts with DUOXA2 (By similarity).
messages: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (By similarity). Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (By similarity). Involved in regulation of reactive oxygen species (ROS) levels (By similarity).
messages: Stimulated by estrogen.
messages: Testis.
messages: The phospho-regulated basic and hydrophobic (PRBH) motif is sufficient and important for interaction with phospholipids permitting cortical localization. Phosphorylation of the PRBH motif by aPKC inhibits the association of the protein with the cortical membrane.
messages: cell cortex

10116:Ccn6
gene id: 10116:Ccn6
uniprot id: D3ZDL5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

10116:Csn1s1
gene id: 10116:Csn1s1
uniprot id: P02661
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the alpha-casein family.
messages: Important role in the capacity of milk to transport calcium phosphate.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted

10116:Or5ak25
gene id: 10116:Or5ak25
uniprot id: A6HMU0
uniprot id: F7FKW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Psat1
gene id: 10116:Psat1
uniprot id: Q68FU2
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.

10116:Hes5
gene id: 10116:Hes5
uniprot id: Q03062
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed predominantly in embryonic neural lineage cells.
messages: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
messages: Nucleus
messages: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
messages: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.
messages: Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).

10116:Ldlrad4
gene id: 10116:Ldlrad4
uniprot id: A0A8I5ZUC8
uniprot id: A6IXW6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Megf9
gene id: 10116:Megf9
uniprot id: A6J807
uniprot id: D4A3L3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Pip4p2
gene id: 10116:Pip4p2
uniprot id: A6II98
uniprot id: Q4V888
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity).
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Cell membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

10116:Ddx59
gene id: 10116:Ddx59
uniprot id: A6ICI8
uniprot id: D4A2T7
uniprot id: Q66HG7
names: Domain
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DDX59 subfamily.
messages: Cytoplasm
messages: Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.
messages: Nucleus
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

10116:Ppp1r14d
gene id: 10116:Ppp1r14d
uniprot id: A6HPE6
uniprot id: Q8K3F4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.
messages: Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity).
messages: Phosphorylated on several residues.

10116:Clasrp
gene id: 10116:Clasrp
uniprot id: Q5HZB6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: It is uncertain whether Met-1 or Met-16 is the initiator.
messages: Nucleus
messages: Phosphorylated in vitro by CLK4.
messages: Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity).
messages: Probably interacts with CLK4.

10116:Pak3
gene id: 10116:Pak3
uniprot id: Q62829
names: Activity Regulation
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-421 and allows the kinase domain to adopt an active structure (By similarity).
messages: Autophosphorylated when activated by CDC42/p21.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Detected at high levels in the brain and at low levels in the testis.
messages: Found in the embryonic CNS with little expression elsewhere.
messages: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK. Interacts with the C-terminal of APP. Interacts with ARHGEF6 and ARHGEF7 (By similarity). Interacts with GIT1 and GIT2 (By similarity).
messages: Neddylated.
messages: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development (PubMed:12890786). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity).

10116:Pigh
gene id: 10116:Pigh
uniprot id: A6HCG2
uniprot id: D4A0Z0
names: Similarity
messages: Belongs to the PIGH family.

10116:Fnbp1l
gene id: 10116:Fnbp1l
uniprot id: Q2HWF0
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Expression in brain declines from 18 dpc to P8 and is undetectable from P14 onwards.
messages: Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures. Interacts with GTP-bound CDC42. Interacts with DAAM1, DIAPH1, DIAPH2, DNM1, DNM2 and WASL/N-WASP. Interacts with ATG3. Interacts (via SH3 domain) with ABI1, WASF2, CDC42 and WIPF1.
messages: Isoform 1 is expressed in brain. Isoform 2 is expressed in brain, kidney and lung. Within the brain expression is seen in cortical neurons, hippocampal pyramidal neurons, hypothalamus and piriform cortex.
messages: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL-WASPIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens (By similarity). May negatively regulate neurite extension and axon branching in developing neurons.
messages: The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation (By similarity).
messages: cell cortex
messages: cytoskeleton

10116:Egfl8
gene id: 10116:Egfl8
uniprot id: A6KTH6
uniprot id: A6KTH7
uniprot id: Q6MG84
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

10116:Sell
gene id: 10116:Sell
uniprot id: Q63762
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
messages: Cell membrane
messages: Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Npy1r
gene id: 10116:Npy1r
uniprot id: A6KFL5
uniprot id: G3V7T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

10116:Or1e31
gene id: 10116:Or1e31
uniprot id: A6HGK9
uniprot id: M0RBK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Hoxa7
gene id: 10116:Hoxa7
uniprot id: M0R7P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

10116:Dnajc17
gene id: 10116:Dnajc17
uniprot id: D3ZSC8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May negatively affect PAX8-induced thyroglobulin/TG transcription.
messages: Nucleus

10116:Tap1
gene id: 10116:Tap1
uniprot id: F7EQP4
uniprot id: P97561
uniprot id: P97949
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
messages: Membrane

10116:Nup93
gene id: 10116:Nup93
uniprot id: A6JY70
uniprot id: Q66HC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus envelope
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC). Component of the p62 complex, a complex composed of NUP62 and NUP54. Forms a complex with NUP35, NUP155, NUP205 and lamin B; the interaction with NUP35 is direct. Does not interact with TPR. Interacts with SMAD4 and IPO7; translocates SMAD4 to the nucleus through the NPC upon BMP7 stimulation resulting in activation of SMAD4 signaling.
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling.
messages: nuclear pore complex

10116:Defb1
gene id: 10116:Defb1
uniprot id: A6IW95
uniprot id: O89117
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
messages: Highly expressed in kidney.
messages: Membrane
messages: Monomer. Homodimer.
messages: Secreted

10116:Zc3h12a
gene id: 10116:Zc3h12a
uniprot id: A0JPN4
uniprot id: A6IS77
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZC3H12 family.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay. Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation. Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity). Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Self regulates by destabilizing its own mRNA. Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (By similarity). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (By similarity). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (By similarity). Also plays a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (By similarity). Affects the overall ubiquitination of cellular proteins. Positively regulates deubiquitinase activity promoting the cleavage at…
messages: Mg(2+) is required for RNase activity.
messages: Nucleus
messages: Oligomer. Found in a deubiquitination complex with TANK, USP10 and ZC3H12A; this complex inhibits genotoxic stress- or interleukin-1-beta-mediated NF-kappaB activation by promoting IKBKG or TRAF6 deubiquitination. Interacts with IKBKG; this interaction increases in response to DNA damage. Interacts with TANK; this interaction increases in response to DNA damage and serves as a bridge to anchor both TANK and USP10 into a deubiquitinating complex. Interacts with TRAF6; this interaction increases in response to DNA damage and is stimulated by TANK. Interacts with USP10; this interaction increases in response to DNA damage and serves as a bridge to anchor both TANK and USP10 into a deubiquitinating complex. Interacts with ZC3H12D. Interacts with TNRC6A. Interacts with IKBKB/IKKB. Interacts with IKBKB/IKKB. Interacts with IKBKB/IKKB. Interacts with BTRC; the interaction occurs when ZC3H12A is phosphorylated in a IKBKB/IKKB-dependent manner. Interacts with IRAK1; this interaction increases the interaction between ZC3H12A and IKBKB/IKKB. Interacts with UPF1; this interaction occurs in a mRNA translationally active- and termination-dependent manner and is essential for ZC3H12A-mediated degradation of target mRNAs. Associates with ribosomes. Interacts with ubiquitin.
messages: P-body
messages: Phosphorylated by IRAK1; phosphorylation is necessary for subsequent phosphorylation by the I-kappa-B-kinase (IKK) complex. Phosphorylated by I-kappa-B-kinases (IKKs) at Ser-435 and Ser-439 upon lipopolysaccharide (LPS) or IL1B stimulation in macrophages through the MyD88-dependent signaling pathway; these phosphorylations promote rapid ubiquitin proteasome-mediated degradation of ZC3H12A in macrophages and hence allows its target mRNAs, such as IL6, to escape from degradation and accumulate during the inflammatory response.
messages: Proteolytically cleaved between Arg-111 and Arg-214 by MALT1 in activated T-cells; cleavage at Arg-111 is critical for promoting ZC3H12A degradation in response to T-cell receptor (TCR) stimulation, and hence is necessary for prolonging the stability of a set of mRNAs controlling T-cell activation and Th17 cell differentiation.
messages: Rough endoplasmic reticulum membrane
messages: The C3H1-type zinc finger domain and C-terminal region are necessary for pre-miRNA binding. The C-terminal region and proline-rich domain are necessary for oligomerization.
messages: Ubiquitinated; ubiquitination is induced in response to interleukin IL1 receptor stimuli in a IKBKB/IKKB and IRAK1-dependent manner, leading to proteasome-mediated degradation.

10116:Chst8
gene id: 10116:Chst8
uniprot id: B1WBV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

10116:Rps19
gene id: 10116:Rps19
uniprot id: A6J917
uniprot id: P17074
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: Component of the small ribosomal subunit (By similarity). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity). Interacts with RPS19BP1 (By similarity).
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).
messages: Cytoplasm
messages: nucleolus

10116:Trpm4
gene id: 10116:Trpm4
uniprot id: Q9ESQ5
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM4 sub-subfamily.
messages: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Essential for the migration but not the maturation of dendritic cells (By similarity). Plays a role in keratinocyte differentiation (By similarity).
messages: Cell membrane
messages: Chimeric cDNA.
messages: Endoplasmic reticulum
messages: Gating is voltage-dependent and repressed by decavanadate. Calmodulin-binding confers the Ca(2+) sensitivity. ATP is able to restore Ca(2+) sensitivity after desensitization. Phosphatidylinositol 4,5-bisphosphate (PIP2)-binding strongly enhances activity, by increasing the channel's Ca(2+) sensitivity and shifting its voltage dependence of activation towards negative potentials. Activity is also enhanced by 3,5-bis(trifluoromethyl)pyrazole derivative (BTP2) (By similarity).
messages: Golgi apparatus
messages: Homotetramer.
messages: Isoform 1 is highly expressed in the testis with a moderate expression in the brain, spleen and thymus. Isoform 2 is only expressed in the brain and spleen.
messages: Phosphorylation by PKC leads to increase the sensitivity to Ca(2+).
messages: Probably non-functional.
messages: Sumoylated. Desumoylated by SENP1.

10116:Olr1319
gene id: 10116:Olr1319
uniprot id: A0A0G2JYP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:ND4
gene id: 10116:ND4
uniprot id: P05508
uniprot id: Q8HIC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

10116:Marchf2
gene id: 10116:Marchf2
uniprot id: Q5I0I2
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR (By similarity). Ubiquitinates and therefore mediates the degradation of DLG1 (By similarity). Regulates the intracellular trafficking and secretion of alpha1-antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3 (By similarity). Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteasomal degradation (By similarity). May be involved in endosomal trafficking through interaction with STX6.
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with STX6; the interaction promotes MARCHF2-mediated ubiquitination and degradation of CFTR (PubMed:15689499). Interacts with MARCHF3 (PubMed:16428329). Interacts with GOPC/CAL; the interaction leads to CFTR ubiquitination and degradation (By similarity). Interacts with CFTR; the interaction leads to CFTR ubiqtuitination and degradation (By similarity). Interacts (via PDZ domain) with DLG1 (via PDZ domains); the interaction leads to DLG1 ubiqtuitination and degradation (By similarity). Interacts with ERGIC3 (By similarity). Interacts with ADRB2 (By similarity). Interacts with IKBKG/NEMO; during the late stages of macrophage viral and bacterial infection; the interaction leads to ubiquitination and degradation of IKBKG/NEMO (By similarity).
messages: Lysosome membrane
messages: The RING-CH-type zinc finger domain is required for E3 ligase activity.
messages: Ubiquitously expressed. Present in liver (at protein level).

10116:Mutyh
gene id: 10116:Mutyh
uniprot id: Q8R5G2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Expressed in brain, spleen, heart, liver and kidney.
messages: Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.
messages: Mitochondrion
messages: Nucleus

10116:Bcl2l1
gene id: 10116:Bcl2l1
uniprot id: A0A0G2JW63
uniprot id: A6KHR4
uniprot id: P53563
uniprot id: Q548R7
uniprot id: Q7TS62
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Bcl-2 family.
messages: Expressed in most tissues. Bcl-X(beta) is specifically expressed in cerebellum, heart, and thymus. In the ovary, the predominant form is Bcl-X(L), with a small but detectable level of Bcl-X(S).
messages: Forms heterodimers with BAX, BAK or BCL2; heterodimerization with BAX does not seem to be required for anti-apoptotic activity (By similarity). Interacts with isoform 1 of SIVA1; the interaction inhibits the anti-apoptotic activity (By similarity). Interacts with IKZF3 (By similarity). Interacts with RTL10/BOP (By similarity). Interacts with DNM1L and CLTA; DNM1L and BCL2L1 isoform BCL-X(L) may form a complex in synaptic vesicles that also contains clathrin and MFF (PubMed:18250306, PubMed:23792689). Interacts (via the loop between motifs BH4 and BH3) with NLRP1 (via LRR repeats), but not with NLRP2, NLRP3, NLRP4, PYCARD, nor MEFV (By similarity). Interacts with BECN1 (By similarity).
messages: Homodimer. Interacts with BCL2L11 (By similarity). Interacts with BAD. Interacts with PGAM5. Interacts with HEBP2. Interacts with p53/TP53 and BBC3; interaction with BBC3 disrupts the interaction with p53/TP53. Interacts with ATP5F1A and ATP5F1B; the interactions mediate the association of isoform Bcl-X(L) with the mitochondrial membrane ATP synthase F(1)F(0) ATP synthase (PubMed:21926988). Interacts with VDAC1 (By similarity). Interacts with BCL2L11 (via BH3) (By similarity). Interacts with RNF183 (By similarity). Interacts with GIMAP3/IAN4 and GIMAP5/IAN5 (By similarity). Interacts with GIMAP5 and HSPA8/HSC70; the interaction between HSPA8 and BCL2L1 is impaired in the absence of GIMAP5 (By similarity). Interacts with isoform 4 of CLU; this interaction releases and activates BAX and promotes cell death (By similarity).
messages: Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).
messages: Isoform Bcl-X(S) promotes apoptosis.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Mitochondrion outer membrane
messages: Nucleus membrane
messages: Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis (By similarity).
messages: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
messages: Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity (By similarity).
messages: The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.
messages: The loop between motifs BH4 and BH3 is required for the interaction with NLRP1.
messages: Ubiquitinated by RNF183 during prolonged ER stress, leading to degradation by the proteosome.
messages: centrosome
messages: cytosol
messages: synaptic vesicle membrane

10116:Hhip
gene id: 10116:Hhip
uniprot id: D3ZGL3
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Bcar1
gene id: 10116:Bcar1
uniprot id: Q63767
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A serine-rich region promotes activation of the serum response element (SRE).
messages: Belongs to the CAS family.
messages: Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with NEDD9.
messages: Cytoplasm
messages: Dephosphorylated by PTPN14 at Tyr-226.
messages: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (By similarity). Implicated in induction of cell migration and cell branching (By similarity). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity).
messages: Forms complexes in vivo with PTK2/FAK1, adapter protein CRKL and LYN kinase. Can heterodimerize with NEDD9. Component of a complex comprised of SH2D3C, BCAR1/CAS, and CRK (By similarity). Within the complex, interacts with SH2D3C (via C-terminus), and CRK (By similarity). Part of a complex comprised of PTPRA, BCAR1, BCAR3 (via SH2 domain) and SRC; the formation of the complex is dependent on intergrin mediated-tyrosine phosphorylation of PTPRA (By similarity). Interacts with BCAR3 (via Ras-GEF domain); the interaction regulates adhesion-dependent serine phosphorylation (By similarity). Interacts with SMAD2 and SMAD3 (By similarity). Interacts with NPHP1 (By similarity). Interacts with PTK2B/PYK2 (By similarity). Interacts (via C-terminus) with SH2D3C/CHAT isoform 2 (via C-terminus) (By similarity). Interacts with activated CSPG4. Interacts with BMX, INPPL1/SHIP2 and PEAK1 (By similarity). Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas (By similarity). Interacts with TNK2 via SH3 domains. Interacts with PTK2B/PYK2 (By similarity). Interacts (when tyrosine-phosphorylated) with tensin TNS1; the interaction is increased by phosphorylation of TNS1 (By similarity).
messages: PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin mediated adhesion of cells to the extracellular matrix.
messages: Phosphorylated by SRC kinase in a EDN1- and PTK2B-mediated manner; phosphorylation strengthens its interaction with BCAR3 as part of the PTK2B/BCAR1/BCAR3/RAP1 signaling pathway.
messages: The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of PTK2/FAK1.
messages: Widely expressed. Higher expression in lung, intestine and testis.
messages: axon
messages: focal adhesion

10116:Aig1
gene id: 10116:Aig1
uniprot id: A0A8I6ABV0
uniprot id: B2RZC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

10116:Rimbp2
gene id: 10116:Rimbp2
uniprot id: A0A8I5ZR68
names: Similarity
messages: Belongs to the RIMBP family.

10116:Egr3
gene id: 10116:Egr3
uniprot id: A0A8L2QCU2
uniprot id: A6HTI6
uniprot id: P43301
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Probable transcription factor involved in muscle spindle development.

10116:Lrrfip2
gene id: 10116:Lrrfip2
uniprot id: A0A8I5ZQP7
uniprot id: A0A8I5ZUL9
uniprot id: A0A8I6A2V6
uniprot id: A0A8I6AUZ7
uniprot id: Q4V7E8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LRRFIP family.
messages: Interacts with DVL3 and FLII (By similarity). Weakly interacts with MYD88 in resting cells. Following LPS-stimulation, the interaction with MYD88 is rapidly enhanced; the complex gradually dissociates to basal levels after 6 hours of stimulation. Interaction with MYD88 is regulated by LPS-induced phosphorylation. In the presence of LPS, competes with FLII for MYD88-binding (By similarity).
messages: May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity).

10116:Ric8b
gene id: 10116:Ric8b
uniprot id: A0A0G2JV09
uniprot id: A0A8I6G7F7
uniprot id: A6IFE8
uniprot id: Q80ZG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction (Probable).
messages: Interacts with GDP-bound G alpha proteins GNAI1, GNAL, GNAS and GNAQ. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.
messages: cell cortex

10116:Smad1
gene id: 10116:Smad1
uniprot id: A0A0G2JSQ6
uniprot id: P97588
uniprot id: Q6P7A6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Found in a complex with SMAD4 and YY1. Interacts with HGS, NANOG and ZCCHC12 (By similarity). Upon C-terminus phosphorylation: forms trimers with another SMAD1 and the co-SMAD SMAD4 (By similarity). Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2, USP15 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with SKOR1. Interacts (via MH2 domain) with LEMD3. Binding to LEMD3 results in at least a partial reduction of receptor-mediated phosphorylation. Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome. Found in a macromolecular complex with FAM83G. Interacts (via MH2 domain) with FAM83G (via MH2 domain); in a SMAD4-independent manner. Interacts with ZC3H3 (By similarity). Interacts with TMEM119 (By similarity). Interacts (via MH1 and MH2 domains) with ZNF8 (By similarity). Interacts with RANBP3L; the interaction increases when SMAD1 is not phosphorylated and mediates SMAD1 nuclear export. Interacts with EGR1; this interaction inhibits SMAD1 dephosphorylation (By similarity). Interacts with SMAD6. Interacts with YAP1 (By similarity).
messages: Nucleus
messages: Phosphorylation of the C-terminal SVS motif by BMP type 1 receptor kinase activates SMAD1 by promoting dissociation from the receptor and trimerization with SMAD4. Phosphorylation by ERK2 MAP kinase in response to EGF or HGF prevents SMAD1 nuclear accumulation and transcriptional activity in response to BMP (By similarity). Dephosphorylation, probably by PPM1A, induces its export from the nucleus to the cytoplasm (By similarity). Dephosphorylation is inhibited by association with EGR1 (By similarity). Phosphorylation by CDK8/9 creates binding sites for YAP1, and subsequent phosphorylation by GSK3 switches off YAP1 binding and adds binding sites for SMURF1 (By similarity).
messages: The MH2 domain mediates phosphorylation-dependent trimerization through L3 loop binding of phosphoserines in the adjacent subunit.
messages: Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis. Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form an heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity).
messages: Ubiquitinated by SMAD-specific E3 ubiquitin ligase SMURF1, leading to its degradation. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes. Dephosphorylation, probably by PPM1A, induces its export from the nucleus to the cytoplasm (By similarity). Phospho-SMAD1 is ubiquitinated by CHIP leading to disruption of the SMAD1-SMAD4 complex (By similarity).
messages: Ubiquitous; present in liver, lung, stomach and spleen with lower level in heart, testes and skeletal muscle.

10116:Ilk
gene id: 10116:Ilk
uniprot id: A6I7L9
uniprot id: Q99J82
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A PH-like domain is involved in phosphatidylinositol phosphate binding.
messages: Autophosphorylated on serine residues.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cell membrane
messages: Interacts with the cytoplasmic domain of ITGB1. Could also interact with integrin ITGB2, ITGB3 and/or ITGB5. Interacts (via ANK repeats) with LIMS1 and LIMS2. Interacts with PARVA (via C-terminus) and PARVB; these compete for the same binding site (By similarity). Interacts probably also with TGFB1I1 (By similarity). Interacts (via ANK repeats) with EPHA1 (via SAM domain); stimulated by EFNA1 but independent of the kinase activity of EPHA1 (By similarity). Interacts with FERMT2 (By similarity). Interacts with LIMD2; leading to activate the protein kinase activity. Interacts with PXN/PAXILLIN (via LD motif 4). Interacts with CCDC25 (via cytoplasmic region); initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (By similarity).
messages: Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Regulates cell motility by forming a complex with PARVB. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
messages: Stimulated rapidly but transiently by both cell fibronectin interactions, as well as by insulin, in a PI3-K-dependent manner, likely via the binding of PtdIns(3,4,5)P3 with a PH-like domain of ILK. The protein kinase activity is stimulated by LIMD2.
messages: focal adhesion
messages: lamellipodium
messages: sarcomere

10116:Ubac1
gene id: 10116:Ubac1
uniprot id: Q5XIR9
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts (via ubiquitin-like domain) with RNF123. Interacts (via ubiquitin-like and UBA domains) with the proteasome via its N-terminal domain.
messages: Cytoplasm
messages: Non-catalytic component of the KPC complex, a E3 ubiquitin-protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1. The KPC complex catalyzes polyubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. The KPC complex also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B by catalyzing ubiquitination of the NFKB1 p105 precursor. Within the KPC complex, UBAC1 acts as an adapter that promotes the transfer of target proteins that have been polyubiquitinated by RNF123/KPC1 to the 26S proteasome.
messages: The UBA domains recognize and bind polyubiquitinated proteins.

10116:Mb
gene id: 10116:Mb
uniprot id: A0A1K0FUB2
uniprot id: Q9QZ76
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

10116:Rem2
gene id: 10116:Rem2
uniprot id: A0JPL9
uniprot id: A6KGU4
uniprot id: Q9WTY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. RGK family.
messages: Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.
messages: Cell membrane
messages: Expressed in brain and kidney.

10116:Hsd17b13
gene id: 10116:Hsd17b13
uniprot id: Q5M875
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Endoplasmic reticulum
messages: Lipid droplet
messages: Plays a pivotal role in hepatic lipid metabolism. In vitro, it catalyzes the oxidation of a variety of lipid substrates, including 17beta-estradiol, retinol, retinal, and leukotriene B4.

10116:Or6z3
gene id: 10116:Or6z3
uniprot id: A0A8I6AGY2
uniprot id: A6KS71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Zfp830
gene id: 10116:Zfp830
uniprot id: A6HHD9
uniprot id: Q3MHS2
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE; this complex binds preferentially to RNA. Interacts with XAB2. Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex. The IB complex does not contain PRPF19.
messages: May play a role in pre-mRNA splicing as component of the spliceosome (By similarity). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: Phosphorylated in response to DNA damage by the cell cycle checkpoint kinases ATR/ATM.

10116:Zfp36
gene id: 10116:Zfp36
uniprot id: A6J9I7
uniprot id: G3V8K6
uniprot id: P47973
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Associates with cytoplasmic CCR4-NOT and PAN2-PAN3 deadenylase complexes to trigger ARE-containing mRNA deadenylation and decay processes. Part of a mRNA decay activation complex at least composed of poly(A)-specific exoribonucleases CNOT6, EXOSC2 and XRN1 and mRNA-decapping enzymes DCP1A and DCP2. Associates with the RNA exosome complex. Interacts (via phosphorylated form) with 14-3-3 proteins; these interactions promote exclusion of ZFP36 from cytoplasmic stress granules in response to arsenite treatment in a MAPKAPK2-dependent manner and does not prevent CCR4-NOT deadenylase complex recruitment or ZFP36-induced ARE-containing mRNA deadenylation and decay processes. Interacts with 14-3-3 proteins; these interactions occur in response to rapamycin in an Akt-dependent manner. Interacts with AGO2 and AGO4. Interacts (via C-terminus) with CNOT1; this interaction occurs in a RNA-independent manner and induces mRNA deadenylation. Interacts (via N-terminus) with CNOT6. Interacts with CNOT6L. Interacts (via C-terminus) with CNOT7; this interaction occurs in a RNA-independent manner, induces mRNA deadenylation and is inhibited in a phosphorylation MAPKAPK2-dependent manner. Interacts (via unphosphorylated form) with CNOT8; this interaction occurs in a RNA-independent manner and is inhibited in a phosphorylation MAPKAPK2-dependent manner. Interacts with DCP1A. Interacts (via N-terminus) with DCP2. Interacts with EDC3. Interacts (via N-terminus) with EXOSC2. Interacts with heat shock 70 kDa proteins. Interacts with KHSRP; this interaction increases upon cytokine-induced treatment. Interacts with MAP3K4; this interaction enhances the association with SH3KBP1/CIN85. Interacts with MAPKAPK2; this interaction occurs upon skeletal muscle satellite cell activation. Interacts with NCL. Interacts with NUP214; this interaction increases upon lipopolysaccharide (LPS) stimulation. Interacts with PABPC1; this interaction occurs in a RNA-dependent manner. Interacts (via hypophosphorylate…
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Nucleus
messages: P-body
messages: Phosphorylated. Phosphorylation at serine and/or threonine residues occurs in a p38 MAPK- and MAPKAPK2-dependent manner. Phosphorylated by MAPKAPK2 at Ser-53 and Ser-179; phosphorylation increases its stability and cytoplasmic localization, promotes binding to 14-3-3 adapter proteins and inhibits the recruitment of cytoplasmic CCR4-NOT and PAN2-PAN3 deadenylase complexes to the mRNA decay machinery, thereby inhibiting ZFP36-induced ARE-containing mRNA deadenylation and decay processes. Phosphorylation by MAPKAPK2 does not impair ARE-containing RNA-binding. Phosphorylated in a MAPKAPK2- and p38 MAPK-dependent manner upon skeletal muscle satellite cell activation; this phosphorylation inhibits ZFP36-mediated mRNA decay activity, and hence stabilizes MYOD1 mRNA. Phosphorylated by MAPK1 upon mitogen stimulation. Phosphorylated at Ser-59 and Ser-86; these phosphorylations increase in a SH3KBP1-dependent manner. Phosphorylated at serine and threonine residues in a pyruvate kinase PKM- and p38 MAPK-dependent manner. Phosphorylation at Ser-53 may participate in the PKM-mediated degradation of ZFP36 in a p38 MAPK-dependent manner. Dephosphorylated by serine/threonine phosphatase 2A at Ser-179.
messages: The C3H1-type zinc finger domains are necessary for ARE-binding activity.
messages: Ubiquitinated; pyruvate kinase (PKM)-dependent ubiquitination leads to proteasomal degradation through a p38 MAPK signaling pathway.
messages: Zinc-finger RNA-binding protein that destabilizes numerous cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:27193233). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs. Self regulates by destabilizing its own mRNA (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:27193233). Binds also to ARE of its own mRNA. Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages. Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response. Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia. Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA. Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA. Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs. Participates in association…
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

10116:Sh2b2
gene id: 10116:Sh2b2
uniprot id: A6J076
uniprot id: Q9Z200
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis (By similarity). Involved in stimulation of glucose uptake by insulin. Involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Induces cytoskeletal reorganization and neurite outgrowth in cultured neurons.
messages: Belongs to the SH2B adapter family.
messages: Cytoplasm
messages: Detected in embryonic brain, spinal cord and cortical neurons.
messages: Homodimer. Interacts with KIT/c-KIT, SHC1, EPOR, PDGFR, VAV1 and VAV3. Interacts (via N-terminal region) with SHC1. Interacts (via the phosphorylated C-terminus) with GRB2. Interacts (via its SH2 domain) with EPOR, INSR and KIT. Interacts with GRB2 after B-cell antigen receptor stimulation. Interacts (via PH domain) with VAV3 (By similarity). Interacts with NTRK1, NTRK2 and NTRK3 (phosphorylated); after stimulation of the receptor by its extracellular ligand and subsequent autophosphorylation of the receptor. Binds INSR, GRB2, ASB6 and CAP. Insulin stimulation leads to dissociation of CAP. Binds CBS only when SH2B2/APS has become phosphorylated. INSR binding does not depend on the phosphorylation of SH2B2/APS.
messages: Membrane
messages: Phosphorylated on a tyrosine residue by NTRK1, NTRK2, NTRK3 and INSR after stimulation of the receptor by its extracellular ligand. Tyrosine phosphorylated by JAK2, KIT and other kinases activated by B-cell receptor in response to stimulation with cytokines, IL3, IL5, PDGF, IGF1, IGF2, CSF2/GM-CSF and cross-linking of the B-cell receptor complex (By similarity).

10116:Olr1087
gene id: 10116:Olr1087
uniprot id: A6K928
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Naip5
gene id: 10116:Naip5
uniprot id: A0A8I6GLQ4
names: Subcellular Location Annotation
messages: Inflammasome

10116:Sult2a6
gene id: 10116:Sult2a6
uniprot id: P22789
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sulfotransferase 1 family.
messages: Cytoplasm
messages: Liver, exhibiting a sex-dependent spatial localization in the lobule of the liver.
messages: Oligomer consisting of several isoelectric variants with the same molecular mass. Relative contents of these isoelectic variants are different in weanling (20 days) than in young adults (110 days).
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze sulfonation of hydroxysteroids and xenobiotics.
messages: The ST activities display gender- and age-dependent alterations and are known to be under the regulation of gonadal, adrenal and growth hormones.
messages: There is a marked sex difference (female >> male) in the cytosolic level of this protein. Its activity increases after birth in parallel in both sexes until the weanling stage. Thereafter the activity decreases in males, whereas it declines temporarily in females and increases again to a maximum level in adult females.

10116:Rpl3l
gene id: 10116:Rpl3l
uniprot id: D4A9G1
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

10116:Appl2
gene id: 10116:Appl2
uniprot id: B4F779
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Early endosome membrane
messages: Endosome membrane
messages: Homodimer. Homotetramer. Binds RAB5A/Rab5 through an N-terminal domain. This interaction is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds subunits of the NuRD/MeCP1 complex. Interacts with FSHR; interaction is independent of follicle stimulating hormone stimulation. Interacts with APPL1; the interaction is decreased by adiponectin in a time-dependent manner. Forms a complex comprising APPL1, RUVBL2, CTNNB1, HDAC1 and HDAC2; interaction reduces interaction between CTNNB1, HDAC1, HDAC2 and RUVBL2 leading to the decrease of deacetylase activity of this complex; affects the recruitment of repressive complexes to the Wnt target genes. Interacts (via BAR domain) with TBC1D1; interaction is dependent of TBC1D1 phosphorylation at 'Ser-235'; interaction diminishes the phosphorylation of TBC1D1 at 'Thr-596', resulting in inhibition of SLC2A4 translocation and glucose uptake. Interacts with ANXA2; targets APPL2 to endosomes and acting in parallel to RAB5A. Interacts with RAB31 (in GTP-bound form); interaction contributes to or enhances recruitment of APPL2 to the phagosomes; interaction enhances Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Interacts with PIK3R1; forms a complex with PIK3R1 and APPL1. Interacts (via BAR domain) with ADIPOR1; hinders the accessibility of APPL1 to ADIPOR1; negatively regulates adiponectin signaling; ADIPOQ dissociates this interaction and facilitates the recruitment of APPL1 to ADIPOR1. Interacts (via BAR domain) with ADIPOR2; ADIPOQ dissociates this interaction (By similarity).
messages: Increases with aging and decreases by short-term exercise training in aging skeletal muscle.
messages: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (By similarity). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (By similarity). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oyidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negativeliy regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (By similarity). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (B…
messages: Nucleus
messages: The BAR domain is necessary and sufficient for mediating homotypic and heterotypic interactions; associates with cytoplasmic membrane structures; mediates interaction with TBC1D1 and ADIPOR1 (By similarity). The PH and PID domains mediate phosphoinositide binding. The PID domain mediates phosphatidylserine binding and allows localization to cytosolic membrane structures and nucleus. The PH domain allows localization to the plasma membrane, cytosolic vesicles and distinct nuclear and perinuclear structures and is sufficient for RUVBL2 interaction (By similarity).
messages: phagosome
messages: phagosome membrane
messages: ruffle
messages: ruffle membrane

10116:Erlin2
gene id: 10116:Erlin2
uniprot id: B5DEH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family.
messages: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity).
messages: Endoplasmic reticulum membrane
messages: Forms a heteromeric complex with ERLIN1. In complex with ERLIN1, interacts with RNF170. Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination. Interacts with SCAP, INSIG1, SREBF1 and SREBF2 under cholesterol sufficiency conditions; indicative for an association with the SCAP-SREBP-INSIG complex. Probably part of an AMFR/gp78 and INSIG1-containing ubiquitin ligase complex involved in ERAD of HMGCR. Interacts with TMUB1; TMUB1 bridges the association with AMFR. Interacts with SYVN1 and RNF139. Interacts with TMEM259 (By similarity). Interacts with TMEM41B (By similarity).

10116:Adgrg6
gene id: 10116:Adgrg6
uniprot id: A0A0G2JST1
uniprot id: A0A8I6ALD7
uniprot id: A0A8I6ALS0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Armc10
gene id: 10116:Armc10
uniprot id: B1WBW4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Interacts with the DNA-binding domain of p53/TP53.
messages: May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53 (By similarity).
messages: Mitochondrion outer membrane

10116:Dclre1b
gene id: 10116:Dclre1b
uniprot id: Q4KLY6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint (By similarity). Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (By similarity). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (By similarity).
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Interacts with TERF2; the interaction is direct. Interacts with MUS81, MRE11 and FANCD2. Interacts with HSPA2, HSPA8 and HSPA14. Interacts with SPAG5 (By similarity).
messages: Nucleus
messages: The TBM domain mediates interaction with TERF2.
messages: Ubiquitinated, leading to its degradation. Interaction with TERF2 protects it from ubiquitination (By similarity).
messages: centrosome
messages: telomere

10116:Hist1h2bg
gene id: 10116:Hist1h2bg
uniprot id: Q00715
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity).
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).
messages: GlcNAcylation at Ser-112 promotes monoubiquitination of Lys-120. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid (By similarity).
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-120 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity).
messages: Nucleus
messages: Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination. Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

10116:Mettl26
gene id: 10116:Mettl26
uniprot id: A6HD72
uniprot id: Q497C3
names: Similarity
messages: Belongs to the UPF0585 family.

10116:Cct3
gene id: 10116:Cct3
uniprot id: A6J662
uniprot id: Q6P502
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG (By similarity). Interacts with DNAAF4 (By similarity). Interacts with DLEC1 (By similarity).
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm

10116:Alox5ap
gene id: 10116:Alox5ap
uniprot id: A6K167
uniprot id: P20291
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Homotrimer. Interacts with LTC4S and ALOX5 (By similarity).
messages: Membrane
messages: Nucleus membrane
messages: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity).
messages: The C-terminal part after residue 140 is mostly disordered.

10116:Ccn1
gene id: 10116:Ccn1
uniprot id: Q66HT5
uniprot id: Q9ES72
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCN family.
messages: Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity).
messages: Secreted

10116:Csde1
gene id: 10116:Csde1
uniprot id: P18395
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts with STRAP. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, HNRPD and SYNCRIP. The interaction with PABPC1 is direct and RNA-independent. Interacts with EIF4ENIF1/4E-T.
messages: Cytoplasm
messages: P-body
messages: RNA-binding protein involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Required for efficient formation of stress granules.
messages: Stress granule

10116:Ntsr2
gene id: 10116:Ntsr2
uniprot id: Q63384
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abundant in cortex and hypothalamus, and lower levels seen in the heart and intestine.
messages: Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.
messages: Cell membrane
messages: Expressed maximally in 7-day-old brain and expression decreases progressively until adulthood (35-day-old brain).
messages: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

10116:Fam89a
gene id: 10116:Fam89a
uniprot id: Q6Q0N2
names: Similarity
messages: Belongs to the FAM89 family.

10116:Oga
gene id: 10116:Oga
uniprot id: Q8VIJ5
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 84 family.
messages: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:8034696). Does not bind acetyl-CoA and does not have histone acetyltransferase activity.
messages: Cytoplasm
messages: Detected in spleen (at protein level). Ubiquitous. Expressed at highest levels in the brain and spleen.
messages: Inhibited by Cu(2+), Hg(2+), Cd(2+) and Zn(2+) at 1 mM. Not inhibited by Co(2+), Mg(2+), Ca(2+), Mn(2+), Fe(3+) and EDTA. Also inhibited by sodium chloride at 1M and 2-amino-2-hydroxymethyl-1,3-propanediol (trishydroxymethylaminomethane) at 75 mM.
messages: Lack hexosaminidase activity.
messages: Lacks enzyme activity.
messages: Monomer. Interacts with CLOCK (By similarity).
messages: Nucleus
messages: Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity.
messages: Was initially identified as a bi-functional protein that has an N-terminal domain with O-GlcNAcase activity and a C-terminal domain that has histone acetyltransferase activity (PubMed:15485860). The protein has apparent histone acetyltransferase activity when expressed in mammalian cells, but not when expressed in bacterial cells (PubMed:15485860), suggesting that the histone acetyltransferase activity might be due to the presence of a contaminant. Characterization of the human ortholog shows that this protein does not bind acetyl-CoA and therefore cannot have acetyltransferase activity.

10116:Cdc25b
gene id: 10116:Cdc25b
uniprot id: P48966
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MPI phosphatase family.
messages: Interacts with MAPK14 and 14-3-3 proteins.
messages: Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-349 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-166 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-319 and Ser-370 by MAPK14 is required for binding to 14-3-3 proteins (By similarity).
messages: Stimulated by B-type cyclins.
messages: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity (By similarity).
messages: centrosome
messages: spindle pole

10116:Shisa5
gene id: 10116:Shisa5
uniprot id: Q5XIH2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shisa family.
messages: Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis.
messages: Endoplasmic reticulum membrane
messages: Nucleus membrane
messages: The proline-rich region is required for endoplasmic reticulum localization.

10116:Cyp4f4
gene id: 10116:Cyp4f4
uniprot id: A6K957
uniprot id: P51869
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its oxygenated derivatives (PubMed:14634044, PubMed:9344476, PubMed:17418803). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:14634044, PubMed:9344476, PubMed:17418803). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:14634044). Hydroxylates the terminal carbon (omega-hydroxylation) of inflammatory lipid mediators, including prostaglandin (PG) A1, PGE1 and leukotriene B4 (LTB4), and may play a role in inactivation of these oxylipins during the resolution of inflammation (PubMed:14634044, PubMed:9344476, PubMed:17418803).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Expressed in hepatocytes (PubMed:17418803). High expression in liver and kidney. Lower expression in brain (PubMed:9344476).
messages: Microsome membrane
messages: Up-regulated in hepatocytes by pro-inflammatory cytokine IL6 and down-regulated by anti-inflammatory cytokine IL10.

10116:Pla2g2f
gene id: 10116:Pla2g2f
uniprot id: A6ITI5
uniprot id: D3ZLB5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

10116:RGD1309489
gene id: 10116:RGD1309489
uniprot id: A0A8I5ZUK4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay.

10116:Capn13
gene id: 10116:Capn13
uniprot id: Q5BK10
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: It is unlikely that this protein binds calcium as none of the 2 EF-hand domains seem to contain a canonical calcium-binding site.
messages: Probable non-lysosomal thiol-protease.

10116:Spsb2
gene id: 10116:Spsb2
uniprot id: A6ILL1
uniprot id: Q5M877
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPSB family.
messages: Component of the probable ECS(SPSB2) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB2 (By similarity). Interacts with CUL5, RNF7, ELOB and ELOC (By similarity). Interacts with MET (By similarity). Interacts (via B30.2/SPRY domain) with PAWR; this interaction occurs in association with the Elongin BC complex (By similarity). Interacts with NOS2 (By similarity).
messages: Cytoplasm
messages: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity).
messages: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). Essential for its ability to link NOS2 and the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity).
messages: cytosol

10116:Tmem131l
gene id: 10116:Tmem131l
uniprot id: A0A8I6AV47
names: Similarity
messages: Belongs to the TMEM131 family.

10116:Dnmt3a
gene id: 10116:Dnmt3a
uniprot id: Q1LZ53
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by binding to the regulatory factor DNMT3L. Auto-methylation at Cys-706 in absence of DNA inactivates the DNA methyltransferase activity.
messages: Auto-methylated at Cys-706: auto-methylation takes place in absence of DNA substrate and inactivates the DNA methyltransferase activity. Inactivation by auto-methylation may be used to inactivate unused DNA methyltransferases in the cell.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Chromosome
messages: Cytoplasm
messages: Heterotetramer composed of 1 DNMT3A homodimer and 2 DNMT3L subunits (DNMT3L-DNMT3A-DNMT3A-DNMT3L) (By similarity). Interacts with DNMT1 and DNMT3B (By similarity). Interacts with MPHOSPH8 (By similarity). Interacts with histone H3 that is not methylated at 'Lys-4' (H3K4) (By similarity). Binds the ZBTB18 transcriptional repressor (By similarity). Interacts with SETDB1 (By similarity). Associates with HDAC1 through its ADD domain. Interacts with UHRF1. Interacts with the PRC2/EED-EZH2 complex. Interacts with UBC9, PIAS1 and PIAS2. Interacts with SPOCD1 (By similarity). Interacts with ZNF263; recruited to the SIX3 promoter along with other proteins involved in chromatin modification and transcriptional corepression where it contributes to transcriptional repression (By similarity).
messages: Nucleus
messages: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-706 in absence of DNA (By similarity).
messages: Sumoylated; sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress transcription.
messages: The PWWP domain is essential for targeting to pericentric heterochromatin. It specifically recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3).

10116:Susd4
gene id: 10116:Susd4
uniprot id: A6JGM6
uniprot id: D4A231
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Elof1
gene id: 10116:Elof1
uniprot id: A6JNZ0
uniprot id: D4AEE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

10116:Phf5a
gene id: 10116:Phf5a
uniprot id: B4F759
uniprot id: P83871
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PHF5 family.
messages: By estrogen.
messages: Expressed in all tissues tested including brain, heart, ovary, uterus, skeletal muscle and testis.
messages: Interacts (via N-terminus) with U2AF1 and SRSF5; acts to bridge the two. Interacts (via C-terminus) with EP400 and DDX1; acts to bridge the two (By similarity). Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A and DDX42. Within the SF3B complex interacts directly with SF3B1 and SF3B3. The SF3B complex composed of SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6 and PHF5A interacts with U2AF2. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (By similarity). Interacts with the PAF1 complex (PAF1C) composed of CDC73, PAF1, LEO1, CTR9, RTF1 and SKIC8. Within the PAF1C interacts directly with CDC73 and SKIC8. Interacts with RNA polymerase II (By similarity).
messages: Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes. Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies. Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation (By similarity). Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (By similarity). Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha (PubMed:12810571).
messages: Nucleus
messages: Nucleus speckle

10116:Fgf18
gene id: 10116:Fgf18
uniprot id: O88182
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the heparin-binding growth factors family.
messages: Expressed in several discrete regions at 14.5 dpc and 19.5 dpc but not 10.5 dpc. At 14.5 dpc, expressed in isthmus, pituitary, spinal cord, tongue, intervertebral disk, dorsal root ganglion and pelvis. At 19.5 dpc, expressed in lung and anterior pituitary.
messages: Interacts with FGFR3 and FGFR4.
messages: Mainly expressed in the lung. Not detected in brain, heart, liver, kidney and small intestine.
messages: Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation (By similarity).
messages: Secreted

10116:Olr920
gene id: 10116:Olr920
uniprot id: A0A8I6AH14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tas2r116
gene id: 10116:Tas2r116
uniprot id: Q67ER8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Putative taste receptor which may play a role in the perception of bitterness.
messages: Several bitter taste receptors are expressed in a single taste receptor cell.

10116:Plgrkt
gene id: 10116:Plgrkt
uniprot id: D4ACN8
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in adrenal medulla (pheochromocytoma).
messages: Interacts with PLAT (By similarity). Interacts with PLAUR.
messages: Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9 (By similarity).

10116:Kcnmb3
gene id: 10116:Kcnmb3
uniprot id: A7VL23
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB3 per KCNMA1 tetramer (By similarity).
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. May partially inactivate the current of KCNBMA. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer (By similarity).
messages: The extracellular domain contains disulfide bond essential for the gating mechanism.
messages: The extracellular domain forms gates to block ion permeation, providing a mechanism by which current can be rapidly diminished upon cellular repolarization.

10116:Pcsk5
gene id: 10116:Pcsk5
uniprot id: A6I0J8
uniprot id: P41413
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: AC 1 and AC 2 (clusters of acidic amino acids) contain sorting information. AC 1 directs TGN localization and interacts with the TGN sorting protein PACS-1.
messages: Belongs to the peptidase S8 family.
messages: Endomembrane system
messages: Expressed in the intestine, brain, adrenal gland, anterior pituitary, thyroid, ovaries, testis and lung. Highest levels are found in the gut, duodenum, jejunum and ileum. Expression is higher in female than in male reproductive organs.
messages: First detected at 9 dpc in highly restricted regions of the neural tube, in caudal myotomes, and at the materno-embryonic junction of the uterus. At 10 dpc, restricted expression is detected in the optic and otic vesicles, the roof of midbrain, and trunk myotomes. By mid-gestation (13 dpc to 16 dpc), expression in the developing nervous system has expanded to multiple regions including hippocampus, thalamus, hypothalamus, brain stem, and spinal cord. Expression is also detected in several peripheral organ systems, including gut, lung, adrenal and kydney primordia.
messages: Secreted
messages: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors.
messages: The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum.

10116:Prpf18
gene id: 10116:Prpf18
uniprot id: A6JM01
uniprot id: Q9JKB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PRP18 family.
messages: Detected in brain, heart, liver and skeletal muscle.
messages: Heterodimer with PPIH. Interacts with PRPF4 and with the spliceosome. Part of a complex containing U4/U6 snRNPs (By similarity). Also detected in the cytoplasm.
messages: Nucleus speckle
messages: Participates in the second step of pre-mRNA splicing (By similarity). Down-regulates the expression of potassium channel subunits.

10116:Kmt5c
gene id: 10116:Kmt5c
uniprot id: A6KNN2
uniprot id: P0C2N6
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).
messages: Homodimer (By similarity). Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2 (By similarity).
messages: Inhibited by 6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine (A-196).
messages: Nucleus
messages: Strongly down-regulated in various cancers such as hepatocarcinomas.

10116:Alkbh1
gene id: 10116:Alkbh1
uniprot id: D3Z8W2
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

10116:Efna5
gene id: 10116:Efna5
uniprot id: A0A8I6GLK9
uniprot id: A6JR96
uniprot id: P97605
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ephrin family.
messages: Binds to the receptor tyrosine kinases EPHA2, EPHA3, EPHB1 and EPHB2. Interacts with EPHA8; activates EPHA8. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function (By similarity).
messages: Cell membrane
messages: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion (By similarity).
messages: Expressed in brain, heart, placenta and lung.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: caveola

10116:Comt
gene id: 10116:Comt
uniprot id: A0A8I6A1I0
uniprot id: F2W8B0
uniprot id: F2W8B1
uniprot id: P22734
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
messages: Cell membrane
messages: Cytoplasm
messages: The N-terminus is blocked.

10116:Mgat5
gene id: 10116:Mgat5
uniprot id: A9CMA3
uniprot id: Q08834
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A secreted form is released from the membrane after cleavage by gamma-secretase.
messages: Belongs to the glycosyltransferase 18 family.
messages: Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides (PubMed:8340368, PubMed:7615638). Catalyzes an important step in the biosynthesis of branched, complex-type N-glycans, such as those found on EGFR, TGFR (TGF-beta receptor) and CDH2 (By similarity). Via its role in the biosynthesis of complex N-glycans, plays an important role in the activation of cellular signaling pathways, reorganization of the actin cytoskeleton, cell-cell adhesion and cell migration (PubMed:7615638). MGAT5-dependent EGFR N-glycosylation enhances the interaction between EGFR and LGALS3 and thereby prevents rapid EGFR endocytosis and prolongs EGFR signaling. Required for efficient interaction between TGFB1 and its receptor. Enhances activation of intracellular signaling pathways by several types of growth factors, including FGF2, PDGF, IGF, TGFB1 and EGF. MGAT5-dependent CDH2 N-glycosylation inhibits CDH2-mediated homotypic cell-cell adhesion and contributes to the regulation of downstream signaling pathways. Promotes cell migration. Contributes to the regulation of the inflammatory response. MGAT5-dependent TCR N-glycosylation enhances the interaction between TCR and LGALS3, limits agonist-induced TCR clustering, and thereby dampens TCR-mediated responses to antigens. Required for normal leukocyte evasation and accumulation at sites of inflammation (By similarity). Inhibits attachment of monocytes to the vascular endothelium and subsequent monocyte diapedesis (By similarity).
messages: Detected in kidney (at protein level). Detected in kidney.
messages: Golgi apparatus membrane
messages: Membrane
messages: N-glycosylated.
messages: Promotes proliferation of umbilical vein endothelial cells and angiogenesis, at least in part by promoting the release of the growth factor FGF2 from the extracellular matrix.
messages: Secreted

10116:Eif1ad
gene id: 10116:Eif1ad
uniprot id: A6HZ44
uniprot id: Q5RKI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Nucleus
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation (By similarity).
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

10116:Taf7
gene id: 10116:Taf7
uniprot id: A0A8I6ABH9
uniprot id: B0BN78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

10116:Dolk
gene id: 10116:Dolk
uniprot id: A6JTW9
uniprot id: D3ZLM6
names: Similarity
messages: Belongs to the polyprenol kinase family.

10116:Atp6v0d2
gene id: 10116:Atp6v0d2
uniprot id: A6IID3
uniprot id: Q5FVL0
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Epididymis and vas deferens.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). Regulator of osteoclast fusion and bone formation (By similarity).
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

10116:Akr1b8
gene id: 10116:Akr1b8
uniprot id: Q91W30
names: Similarity
messages: Belongs to the aldo/keto reductase family.

10116:Echs1
gene id: 10116:Echs1
uniprot id: A6HXG6
uniprot id: P14604
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Converts unsaturated trans-2-enoyl-CoA species ((2E)-enoyl-CoA) to the corresponding 3(S)-3-hydroxyacyl-CoA species through addition of a water molecule to the double bond (PubMed:7883013, PubMed:10074351). Catalyzes the hydration of medium- and short-chained fatty enoyl-CoA thioesters from 4 carbons long (C4) up to C16 (PubMed:7883013, PubMed:10074351). Has high substrate specificity for crotonyl-CoA ((2E)-butenoyl-CoA) and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA) and methacrylyl-CoA ((2E)-2-methylpropenoyl-CoA). Can bind tiglyl-CoA (2-methylcrotonoyl-CoA), but hydrates only a small amount of this substrate (By similarity). Plays a key role in the beta-oxidation spiral of short- and medium-chain fatty acid oxidation (PubMed:7883013). At a lower rate than the hydratase reaction, catalyzes the isomerase reaction of trans-3-enoyl-CoA species (such as (3E)-hexenoyl-CoA) to trans-2-enoyl-CoA species (such as (2E)-hexenoyl-CoA), which are subsequently hydrated to 3(S)-3-hydroxyacyl-CoA species (such as (3S)-hydroxyhexanoyl-CoA) (PubMed:10074351).
messages: Detected in liver (at protein level).
messages: Homohexamer; dimer of trimers.
messages: Mitochondrion matrix

10116:Htr6
gene id: 10116:Htr6
uniprot id: A0A8L2QXZ5
uniprot id: A6ITK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

10116:C1ql2
gene id: 10116:C1ql2
uniprot id: A0A3B0IP42
uniprot id: A0A9K3Y724
names: Subcellular Location Annotation
messages: Secreted

10116:Slfn13
gene id: 10116:Slfn13
uniprot id: A0A5H1ZRV0
uniprot id: Q5U311
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Schlafen family. Subgroup III subfamily.
messages: Can also use Mn(2+).
messages: Cytoplasm
messages: Endoribonuclease that cleaves tRNAs and rRNAs (PubMed:29563550). Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem (PubMed:29563550). Does not act on tRNA(Sec) (PubMed:29563550).
messages: Shows a pseudo-dimeric U-pillow-shaped architecture of the SLFN13 N'-domain that may clamp base-paired RNAs.

10116:Cds2
gene id: 10116:Cds2
uniprot id: Q91XU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:29253589). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (By similarity). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (By similarity).
messages: Endoplasmic reticulum membrane
messages: Homodimer.

10116:Slc22a6
gene id: 10116:Slc22a6
uniprot id: O35956
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basal cell membrane
messages: Basolateral cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Cell membrane
messages: Down-regulated by PGE2 and in ischemic kidney.
messages: Glycosylated. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane.
messages: Highly expressed in kidney; in the particular segment of the proximal tubule (PubMed:9374486, PubMed:9228014). In kidney, found preferentially in the cortex and outer medulla and weakly in the inner medulla (PubMed:9228014). Expressed to a lower extent in brain (PubMed:9228014).
messages: Involved in the renal transport of a variety of drugs with well-known nephrotoxic potential, therefore may play a role in the etiology of the drug-associated nephrotoxicity (PubMed:10462545). Uptakes the diagnostic agent PAH/para-aminohippurate and clinically used drugs (PubMed:9374486, PubMed:9228014, PubMed:10462545, PubMed:23832370). Mediates the bidirectional transport of PAH/para-aminohippurate (By similarity).
messages: Multiple cysteine residues are necessary for proper targeting to the plasma membrane.
messages: Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as alpha-ketoglutarate or glutarate (PubMed:9374486, PubMed:9228014, PubMed:14675047, PubMed:23832370). Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine (By similarity). Function as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4) dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins (By similarity). Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion (PubMed:9228014). Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP (PubMed:9228014). Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) and may contribute to their secretion from the brain (PubMed:23832370). May transport glutamate (By similarity). Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body (PubMed:9228014, PubMed:14675047). Uremic toxins include the indoxyl sulfate (IS), hippurate, indole acetate (IA), 3-carboxy-4- methyl-5-propyl-2-furanpropionate(CMPF) and urate (PubMed:9228014, PubMed:14675047). Xenobiotics include the mycotoxin ochratoxin (OTA) (By similarity). May also contribute to the transport of organic compounds in testes across the blood-testis-barrier (By similarity). May also work as a bidirectional OA/dicarboxylate exchanger (PubMed:9228014).

10116:Cfi
gene id: 10116:Cfi
uniprot id: Q9WUW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S1 family.
messages: Expressed in the liver by hepatocytes. Also present in other cells such as monocytes, fibroblasts or keratinocytes.
messages: Heterodimer of a light and heavy chains; disulfide-linked. The fully processed and mature protein circulates as a zymogen, and is allosterically activated by substrate-induced remodeling of the active site. Interacts with C3b. Interacts with complement factor H.
messages: Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization.
messages: extracellular space

10116:RGD1563270
gene id: 10116:RGD1563270
uniprot id: A0A8I6GE18
names: Similarity
messages: Belongs to the XLR/SYCP3 family.

10116:Gzf1
gene id: 10116:Gzf1
uniprot id: D3ZUU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Interacts with NCL.
messages: Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression.
messages: nucleolus
messages: nucleoplasm

10116:Cep20
gene id: 10116:Cep20
uniprot id: A0A0G2JYM1
uniprot id: B0BN31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

10116:Cct2
gene id: 10116:Cct2
uniprot id: A6IGR4
uniprot id: Q5XIM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Interacts with FLCN (By similarity). Interacts with DLEC1 (By similarity).
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm

10116:Olr1302
gene id: 10116:Olr1302
uniprot id: A0A8I6A7I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ogfod1
gene id: 10116:Ogfod1
uniprot id: A6JY77
uniprot id: D4ACB4
names: Similarity
messages: Belongs to the TPA1 family.

10116:Mtm1
gene id: 10116:Mtm1
uniprot id: Q6AXQ4
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by phosphatidylinositol 5-phosphate (PI5P).
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Heterodimer with MTMR12. Interacts with KMT2A/MLL1 (via SET domain). Interacts with DES in skeletal muscle but not in cardiac muscle. Interacts with SPEG.
messages: Late endosome
messages: Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels.
messages: The GRAM domain mediates binding to PI(3,5)P2 and, with lower affinity, to other phosphoinositides.
messages: filopodium
messages: ruffle
messages: sarcomere

10116:Mafb
gene id: 10116:Mafb
uniprot id: P54842
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context (By similarity). Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity).
messages: Belongs to the bZIP family. Maf subfamily.
messages: Expressed at low levels in a variety of tissues, including liver, muscle and spleen. Strongly expressed in hypertrophic chondrocytes of the femur epiphysis, while expression is very weak in immature proliferating chondrocytes (at protein level).
messages: Expressed in the cartilage of ribs and limbs, in the eyes and spinal cord at 15 dpc (at protein level). Expressed in the lens epithelium at 13 and 16 dpc; not detected in the fiber cells of the lens. In the eyes, confined in the equator of the lens; not detected in the retina at 15 dpc. In spinal cord, expressed in the ventral part of the dorsal horn and the ventral horn at 15 dpc. Predominantly expressed in postmitotic cells.
messages: Homodimer or heterodimer with other bHLH-Zip transcription factors. Forms homodimers and heterodimers with FOS, FOSB and FOSL2, but not with JUN proteins (JUN, JUNB and JUND). Binds DNA as a homodimer or a heterodimer. Interacts with the intracellular cytoplasmic domain of LRP1 (LRPICD); the interaction results in a moderate reduction of MAFB transcriptional potential. Interacts with PAX6; the interaction is direct. Interacts with ETS1 and LRP1 (By similarity).
messages: Nucleus
messages: Sumoylated. Sumoylation on Lys-32 and Lys-297 stimulates its transcriptional repression activity and promotes macrophage differentiation from myeloid progenitors (By similarity).
messages: The leucine-zipper domain is involved in the interaction with LRPICD.

10116:Ahi1
gene id: 10116:Ahi1
uniprot id: Q6DTM3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development.
messages: Self-associates. Part of the tectonic-like complex (also named B9 complex). Interacts with MKS1. Interacts with NPHP1; probably as heterodimers and/or AHI1(2):NPHP1(2) heterotetramers. Interacts (via SH3 domain) with the dynamin GTPase DNM2. Interacts with HAP1; probably as AHI1(2):HAP1(2) heterotetramers. Interacts with RAB8A. Interacts with CEND1 (By similarity). Interacts with SPATA7 (By similarity).
messages: adherens junction
messages: centriole
messages: cilium basal body

10116:Gnat3
gene id: 10116:Gnat3
uniprot id: A6K5D8
uniprot id: P29348
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: By bitter compounds denatonium and quinine.
messages: Cytoplasm
messages: Expressed in scattered solitary ovoid or bipolar cells among the oral epithelium from day 1-7, but with higher frequency in the soft palate as compared with the nasoincisor, circumvallate, and foliate papillae at day 1. During the second week, the solitary cells could no longer be recognized while cells expressing GNAT3 within the taste buds gradually increased. The onset of taste transduction accomplished by the palatal taste buds developed earlier than that achieved by taste buds in the circumvallate and foliate papillae.
messages: Expressed in taste buds (sensory organs of clustered epithelial cells) of the circumvallate, foliate and fungiform papillae of the tongue, as well as in nasoincisor, palatal and epiglottal taste buds at protein level. Expressed in enteroendocrine of the gut, in the lumenal pole of a subset of brush cells lining the stomach and the intestine at protein level. Detected in solitary cells throughout the respiratory track. Expressed also in spermatozoa.
messages: G proteins are composed of 3 units; alpha, beta and gamma, respectively GNAT3, GNB1 and GNG13 for Gustducin heterotrimer for bitter taste transduction. The alpha chain contains the guanine nucleotide binding site. Gustducin heterotrimer may also be composed of GNAT3, GNB3 and GNG13.
messages: Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications for the prevention and treatment of malabsorption syndromes and diet-related disorders including diabetes and obesity.
messages: Potential N-myristoylation may anchor alpha-subunit to the inner surface of plasma membrane.
messages: Transgenic expression of GNAT3 restores responsiveness of GNAT3 deficient mice to both bitter and sweet compounds, whereas expression of mutated Gly-352 transgene do not. Furthermore, in wild-type mice, this mutated transgene acts as dominant-negative by inhibition of endogenous GNAT3 interactions with taste receptors.

10116:Gmpr2
gene id: 10116:Gmpr2
uniprot id: Q5FVP6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Lax1
gene id: 10116:Lax1
uniprot id: Q5FVQ5
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.
messages: Phosphorylated on tyrosines upon TCR or BCR activation; which leads to the recruitment of GRB2, PIK3R1 and GRAP2.
messages: When phosphorylated, interacts with GRB2, PIK3R1 and GRAP2.

10116:Sesn2
gene id: 10116:Sesn2
uniprot id: A0A8I5Y865
uniprot id: B2GUV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

10116:Pth
gene id: 10116:Pth
uniprot id: A6I885
uniprot id: P04089
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the parathyroid hormone family.
messages: Hypothalamus and parathyroid gland.
messages: Interacts with PTH1R (via N-terminal extracellular domain).
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
messages: Secreted

10116:COX2
gene id: 10116:COX2
uniprot id: P00406
uniprot id: Q8SEZ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Binds a dinuclear copper A center per subunit.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16 (By similarity).
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

10116:Asb6
gene id: 10116:Asb6
uniprot id: Q6AYC9
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

10116:Grem2
gene id: 10116:Grem2
uniprot id: A6JGB0
uniprot id: D3ZXD0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

10116:Plcb1
gene id: 10116:Plcb1
uniprot id: P10687
uniprot id: R9PXY3
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds 1 Ca(2+) ion per subunit.
messages: Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier.
messages: Cytoplasm
messages: Highest expression in brain. Also expressed in parotid gland, liver, uterus, lung, heart, adrenal gland and ovary. Not detected in spleen, pancreas, intestine, thymus or kidney.
messages: Interacts with DGKQ.
messages: Nucleus membrane
messages: Palmitoylated. Palmitoylation at Cys-17 by ZDHHC21 regulates the signaling activity of PLCB1 and the function of the endothelial barrier. Palmitoylation by ZDHHC21 is stimulated by inflammation.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
messages: The receptor-mediated activation of PLC-beta-1 is mediated by two G-protein alpha subunits, alpha-Q and alpha-11.

10116:Hr
gene id: 10116:Hr
uniprot id: A0A0G2K5M5
uniprot id: A6HTL6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

10116:Wnt5a
gene id: 10116:Wnt5a
uniprot id: A0A8I5YBK7
uniprot id: F2Z3U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

10116:Cryge
gene id: 10116:Cryge
uniprot id: P02528
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Detected in the superior olivary complex and fibers of the ventral aoustic stria of the auditory hindbrain.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: There are six different gamma crystallins identified in rat lens.

10116:Rsl24d1
gene id: 10116:Rsl24d1
uniprot id: Q6P6G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with nucleolar and cytoplasmic pre-60S particles (By similarity). At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homolog, RPL24 (By similarity).
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity).
messages: nucleolus

10116:Bsnd
gene id: 10116:Bsnd
uniprot id: Q8R2H3
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expressed along the distal nephron.
messages: Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter.
messages: Interacts with CLCNK channels. Forms probably heteromers with CLCNKA and CLCNKB.
messages: Palmitoylation is necessary for activation of plasma membrane-inserted CLC-K/barttin channels.
messages: Regulated in parallel with CLCNKA under furosemide treatment. A significant decrease occurred after furosemide treatment in inner medulla (0.5 fold), whereas cortical and outer medulla levels remained unaffected. Regulation with CLCNKA in inner medulla is limited to the thin limb; levels in collecting ducts were not affected by furosemide treatment. During furosemide treatment selective down-regulation with CLCNKA in thin limb plays a role in maintaining salt and water homeostasis.

10116:Cldn22
gene id: 10116:Cldn22
uniprot id: A6JPK2
uniprot id: D3ZEF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

10116:Olr1328
gene id: 10116:Olr1328
uniprot id: A0A0G2K0K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ggnbp2
gene id: 10116:Ggnbp2
uniprot id: Q6GVH5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasmic vesicle
messages: Interacts with GGN.
messages: May be involved in spermatogenesis.

10116:P3h2
gene id: 10116:P3h2
uniprot id: Q4KLM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the leprecan family.
messages: Detected at low levels in cartilage.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (PubMed:21757687). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4-hydroxyproline in the third position (By similarity).
messages: Sarcoplasmic reticulum

10116:Ipo13
gene id: 10116:Ipo13
uniprot id: A0A9K3Y899
uniprot id: Q9JM04
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the importin beta family.
messages: By cortisol.
messages: Cytoplasm
messages: Differentially expressed in fetal lung with highest levels at gestational days 14 to 16.
messages: Expressed in fetal brain, heart, intestine and kidney.
messages: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13 (By similarity).
messages: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
messages: Nucleus

10116:Fxyd3
gene id: 10116:Fxyd3
uniprot id: A6JA66
uniprot id: P59645
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes.
messages: Belongs to the FXYD family.
messages: Cell membrane
messages: Glutathionylated.
messages: Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, a non-catalytic beta subunit and an additional regulatory subunit. Interacts with catalytic alpha subunit ATP1A1. Also interacts with non-catalytic beta subunit ATP1B1. Interacts with the alpha1-beta1, alpha2-beta1 and alpha3-beta1 NKA isozymes.

10116:Qrfp
gene id: 10116:Qrfp
uniprot id: P83860
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RFamide neuropeptide family.
messages: Expressed in the brain with highest expression levels in the hypothalamus and optic nerve. Also expressed in the trachea and mammary gland.
messages: Ligand for the G-protein coupled receptor QRFPR/GPR103.
messages: Secreted
messages: Stimulates feeding and grooming behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland.

10116:Dis3
gene id: 10116:Dis3
uniprot id: B2RYL7
names: Similarity
messages: Belongs to the RNR ribonuclease family.

10116:Scnm1
gene id: 10116:Scnm1
uniprot id: A6K2U8
uniprot id: D3ZSG1
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: nucleoplasm

10116:Tubb5
gene id: 10116:Tubb5
uniprot id: A6KT85
uniprot id: P69897
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Heterodimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with CIMAP3. Interacts with DIAPH1 (By similarity). Interacts with MX1 (By similarity). May interact with RNABP10 (By similarity). Interacts with CFAP157 (By similarity). Nascent tubulin polypeptide interacts (via beta-tubulin MREI motif) with TTC5/STRAP; this interaction results in tubulin mRNA-targeted degradation (By similarity).
messages: Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility.
messages: The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: Ubiquitously expressed with highest levels in spleen, thymus and immature brain.
messages: cytoskeleton

10116:Tpbg
gene id: 10116:Tpbg
uniprot id: Q5PQV5
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cell membrane
messages: Highly glycosylated.
messages: May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
messages: The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway.

10116:Etv4
gene id: 10116:Etv4
uniprot id: A6HJF1
uniprot id: E9PTJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

10116:Cst8
gene id: 10116:Cst8
uniprot id: O88969
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Performs a specialized role during sperm development and maturation.
messages: Secreted

10116:Akp3
gene id: 10116:Akp3
uniprot id: Q9JKS8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

10116:Ppp1r16b
gene id: 10116:Ppp1r16b
uniprot id: D4AA72
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Atg4c
gene id: 10116:Atg4c
uniprot id: A0A8I5ZXZ8
uniprot id: A6JRL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

10116:Ap5m1
gene id: 10116:Ap5m1
uniprot id: A6KE84
uniprot id: Q499N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.
messages: Belongs to the adaptor complexes medium subunit family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.
messages: cytosol

10116:Gnai3
gene id: 10116:Gnai3
uniprot id: A6HUY0
uniprot id: P08753
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha subunit contains the guanine nucleotide binding site (PubMed:2159473). GTP binding causes dissociation of the heterotrimer, liberating the individual subunits so that they can interact with downstream effector proteins. Forms a complex with CCDC88A/GIV and EGFR which leads to enhanced EGFR signaling and triggering of cell migration; ligand stimulation is required for recruitment of GNAI3 to the complex (PubMed:20462955). Interacts (inactive GDP-bound form) with CCDC88A/GIV (via GBA motif); the interaction leads to activation of GNAI3 (PubMed:19211784). Interacts (inactive GDP-bound form) with CCDC88C/DAPLE (via GBA motif); the interaction leads to activation of GNAI3 (By similarity). Interacts (inactive GDP-bound form) with NUCB1 (via GBA motif) and NUCB2 (via GBA motif); the interaction leads to activation of GNAI3 (PubMed:21653697). Interacts (inactive GDP-bound form) with PLCD4 (via GBA motif); the interaction leads to activation of GNAI3 (By similarity). Interacts with INSR; the interaction is probably mediated by CCDC88A/GIV (PubMed:25187647). Interacts with GPSM1 (PubMed:11121039). Interacts (GDP-bound form) with GPSM2 (via GoLoco domains). Does not interact with RGS2. Interacts with RGS8 and RGS10; this strongly enhances the intrinsic GTPase activity (By similarity). Interacts with RGS12 (PubMed:11387333). Interacts with RGS16; this strongly enhances the intrinsic GTPase activity (By similarity). Interacts (via active GTP- or inactive GDP-bound form) with RGS14 (PubMed:11387333, PubMed:16870394).
messages: Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:2159473). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels. Stimulates the activity of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.
messages: Ubiquitous.
messages: centrosome

10116:Or8k33
gene id: 10116:Or8k33
uniprot id: A0A8I5ZYA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:P3h3
gene id: 10116:P3h3
uniprot id: B5DFB0
names: Similarity
messages: Belongs to the leprecan family.

10116:Or5w14
gene id: 10116:Or5w14
uniprot id: D3ZKQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Gmps
gene id: 10116:Gmps
uniprot id: Q4V7C6
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.
messages: Expressed in the testis, brain, thymus and ovary.
messages: Homodimer.
messages: cytosol

10116:Cald1
gene id: 10116:Cald1
uniprot id: Q62736
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration.
messages: Belongs to the caldesmon family.
messages: High-molecular-weight caldesmon (h-caldesmon) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (l-caldesmon) is widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
messages: In non-muscle cells, phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization. CDK1-mediated phosphorylation promotes Schwann cell migration during peripheral nerve regeneration.
messages: The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the smooth-muscle form.
messages: cytoskeleton
messages: myofibril
messages: stress fiber

10116:Or4p18b
gene id: 10116:Or4p18b
uniprot id: A0A8I6APH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Dus4l
gene id: 10116:Dus4l
uniprot id: A0A0G2K3I5
uniprot id: A6HB53
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

10116:C5h1orf174
gene id: 10116:C5h1orf174
uniprot id: Q5M951
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

10116:Slc25a46
gene id: 10116:Slc25a46
uniprot id: B2RYK4
uniprot id: Q5EB62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex. May associate with the endoplasmic reticulum membrane protein complex (EMC).
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization. May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane. Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission.
messages: Widely expressed. Highly expressed in hindbrain, spinal cord and brain coronal sections containing corpus callosum, fornix, optic chiasm, thalamus, hypothalamus, midbrain, pons and cerebellum.

10116:Gabrb3
gene id: 10116:Gabrb3
uniprot id: P63079
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB3 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Expressed in brain (at protein level).
messages: Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (PubMed:2548852, PubMed:2540033, PubMed:9092594). Can form functional homopentamers (in vitro) (By similarity). Interacts with UBQLN1 (PubMed:11528422). May interact with KIF21B (PubMed:25172774). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (PubMed:28279354). Interacts with LHFPL4 (By similarity). Interacts with GIT1; this interaction is required for synaptic GABRB3 surface stability and inhibitory synapse strength (PubMed:25284783).
messages: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2548852, PubMed:2540033). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA- gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta3/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Plays an important role in somatosensation and in the production of antinociception (By similarity).
messages: Postsynaptic cell membrane

10116:RGD1562011
gene id: 10116:RGD1562011
uniprot id: W8W3Q5
names: Subcellular Location Annotation
messages: Membrane

10116:Ttyh3
gene id: 10116:Ttyh3
uniprot id: A0A0G2K0W3
uniprot id: A6K1R8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable chloride channel.

10116:Grifin
gene id: 10116:Grifin
uniprot id: O88644
names: Developmental Stage
names: Domain
names: Subunit
names: Tissue Specificity
messages: Homodimer.
messages: Increases during lens maturation (at protein level).
messages: Lens-specific. Located at the interface between lens fiber cells (at protein level).
messages: The galectin domain is atypical and does not bind beta-galactoside sugars.

10116:Tlcd4
gene id: 10116:Tlcd4
uniprot id: D4AAE5
names: Subcellular Location Annotation
messages: Membrane

10116:Map1s
gene id: 10116:Map1s
uniprot id: P0C5W1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MAP1A/MAP1B/MAP1S family.
messages: Expressed in cortex cerebellum, dorsal root ganglia, frontal cortex, hippocampus, hypothalamus, mesencephalon, medulla oblongata, occipital cortex, pons, spinal cord, striatum of the brain, neurons, heart, testis and skeletal muscle (at protein level).
messages: Heterodimer of a heavy and a light chain. Interacts with microtubules and actin. Both MAP1S heavy and light chains interact with microtubules. MAP1S light chain interacts with actin. Interacts with LRPPRC, RASSF1, microtubules and VCY2. Interacts (via C-terminus) with GAN (via Kelch domains). Interacts with WDR47 (via N-terminus of light chain) (By similarity). Interacts with ESR1.
messages: Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).
messages: Nucleus
messages: The N-terminus of the heavy chain associates with the C-terminus of the light chain to form the heterodimer complex. Its C-terminal part of the heavy chain interacts with ESR1 (By similarity).
messages: cytoskeleton
messages: cytosol
messages: spindle

10116:Cert1
gene id: 10116:Cert1
uniprot id: A0A8I5ZRB1
uniprot id: A6I509
uniprot id: A6I510
uniprot id: D4ACN6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus

10116:Mex3c
gene id: 10116:Mex3c
uniprot id: A6IY13
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

10116:Taz
gene id: 10116:Taz
uniprot id: Q4KLG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.
messages: Associates with multiple protein complexes.
messages: Belongs to the taffazin family.
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

10116:Tnr
gene id: 10116:Tnr
uniprot id: Q05546
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tenascin family.
messages: Brain-specific (PubMed:7679676). Expressed in oligodendrocytes and small subsets of neurons (mainly interneurons and motoneurons) of the cerebellum, hippocampus and olfactory bulb (PubMed:7679676). Expressed in dorsal root ganglia (PubMed:28270793).
messages: Contains N-linked oligosaccharides, O-linked sialylated structures (By similarity). Contains O-linked chondroitin sulfate glycosaminoglycans. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type GalNAc-4-SO4 or HNK-1 (SO4-3-GlcUABeta1,3GalBeta1,4GlcNAc). The levels of HNK-1 rise and fall in parallel to those of TNR during postnatal development of the cerebellum. In contrast, levels of GalNAc-4-SO4 are regulated independently from those of TNR, rising late in cerebellar development and continuing into adulthood. Early in postnatal development, GalNAc-4-SO4 is found predominantly on isoform 1, whereas in the adult it is predominantly on isoform 2.
messages: Expression in oligodendrocytes is highest between the second and third postnatal week and low in the adult. In contrast the expression in neurons increases from birth to third postnatal week and is continuous from late development to adulthood. Isoform 1 is the dominant form early in development. Isoform 2 is more prominent later in development and in adulthood.
messages: Forms oligomers. Interacts with TNC and FN1 (By similarity). Interacts with BCAN and ACAN in a calcium -dependent manner. Interacts with CNTN1, SCN2B, PTPRZ1, and CSPG3.
messages: Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Theses interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediates inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity).
messages: The EGF-like domains mediate interaction with CNTN1. The fibronectin type-III domains 3-5 mediate interaction with BCAN. The fibronectin type-III domains 1-2 and 7-9 mediate interaction with SCN2B.
messages: Transiently increased in dorsal root ganglia 1 day post-dorsal rhizotomy, returning to comparable levels 3 days post-injury (PubMed:28270793). Increased in dorsal root ganglia in response to both sciatic nerve crush and transection injury (PubMed:28270793).
messages: extracellular matrix

10116:Vps26a
gene id: 10116:Vps26a
uniprot id: A0A8L2QWS2
uniprot id: A6K446
uniprot id: A6K447
uniprot id: A6K449
uniprot id: Q6AY86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3.The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC complex seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required for retrograde transport of lysosomal enzyme receptor IGF2R. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for the endosomal localization of WASHC2 (indicative for the WASH complex). Required for the endosomal localization of TBC1D5. Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP. Involved in retromer-independent lysosomal sorting of F2R. Involved in recycling of ADRB2. Acts redundantly with VSP26B in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1. Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity).
messages: Belongs to the VPS26 family.
messages: Component of the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35. The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform. The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described retromer complex (also called SNX-BAR retromer) is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX-BAR subcomplex to form the SNX27-retromer complex. Interacts with VPS29, VPS35, SNX27, SNX1, SNX2, SNX5, SNX6, SNX3, RAB7A, ECPAS, EHD1, WASHC5, SORL1 (By similarity).
messages: Cytoplasm
messages: Early endosome
messages: Endosome
messages: Endosome membrane

10116:Gtf2h3
gene id: 10116:Gtf2h3
uniprot id: A6J0Y2
uniprot id: Q561R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription (By similarity). Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7 (By similarity).
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

10116:Ubc
gene id: 10116:Ubc
uniprot id: Q63429
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family.
messages: Cytoplasm
messages: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
messages: For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.
messages: Mitochondrion outer membrane
messages: Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.
messages: Nucleus
messages: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.
messages: Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40 and eS31, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.

10116:Hoxd3
gene id: 10116:Hoxd3
uniprot id: D3Z957
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

10116:Galt
gene id: 10116:Galt
uniprot id: A6IIX1
uniprot id: P43424
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 2 zinc ions per subunit.
messages: Homodimer.
messages: Plays an important role in galactose metabolism.

10116:Sco1
gene id: 10116:Sco1
uniprot id: A6HFH6
uniprot id: B0BNM7
uniprot id: G3V985
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCO1/2 family.
messages: Mitochondrion inner membrane

10116:Ptprc
gene id: 10116:Ptprc
uniprot id: P04157
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
messages: Cell membrane
messages: Heavily N- and O-glycosylated.
messages: Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes. Binds GANAB and PRKCSH (By similarity).
messages: Isoform 1 and isoform 2 are found in thymocyte and lymph node. Isoform 4 and isoform 3 are found in the lymph nod.
messages: Membrane raft
messages: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
messages: The cytoplasmic domain contains potential phosphorylation sites.
messages: The first PTPase domain interacts with SKAP1.

10116:Hoxa11
gene id: 10116:Hoxa11
uniprot id: A6K0R5
uniprot id: G3V6Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

10116:Ssr2
gene id: 10116:Ssr2
uniprot id: B5DEQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

10116:Fbxo39
gene id: 10116:Fbxo39
uniprot id: Q66H10
names: Function
names: Sequence Caution
names: Subunit
messages: Contaminating sequence. Potential poly-A sequence.
messages: Directly interacts with SKP1 and CUL1.
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

10116:Lzts1
gene id: 10116:Lzts1
uniprot id: Q8CFC9
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the LZTS family.
messages: Binds EEF1G, TLK2 and CDK1.
messages: Cell membrane
messages: Cytoplasm
messages: Highly expressed in brain, in particular in cortex, the CA2 region of the hippocampus, olfactory bulb, striatum and pons. Not detectable in the other tissues tested.
messages: Highly expressed in cerebellum in 1 to 3 week old rats. Expression levels before and after are much lower. Expression in total brain increases slightly during development and remains at a constant high level after birth.
messages: Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor (By similarity).
messages: Phosphorylated on serine residues. Hyperphosphorylated by the cAMP-dependent kinase PKA during cell-cycle progression (By similarity).
messages: Postsynaptic density
messages: Synapse
messages: dendritic spine

10116:RT1-N3
gene id: 10116:RT1-N3
uniprot id: A0A023GRW5
uniprot id: Q6MG01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Membrane

10116:Hipk3
gene id: 10116:Hipk3
uniprot id: O88850
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Autophosphorylation is not required for catalytic activity.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.
messages: Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and FADD. Interacts with UBL1/SUMO-1 (By similarity). Interacts with and stabilizes ligand-bound androgen receptor (AR).
messages: May be sumoylated.
messages: Nucleus
messages: Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors.

10116:Dennd5a
gene id: 10116:Dennd5a
uniprot id: A0A8I6AMA0
uniprot id: G3V7Q0
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RAB6IP1 family.
messages: Expressed in developing brain and developing neurons.
messages: Golgi apparatus membrane
messages: Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Involved in the negative regulation of neurite outgrowth (PubMed:27866705).
messages: In the brain, expression is high at embryonic day 18 and continually decreases through to postnatal day 60.
messages: Interacts with RAB6A bound to GTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Usp7
gene id: 10116:Usp7
uniprot id: A0A8I6AKU3
uniprot id: Q4VSI4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase C19 family.
messages: Chromosome
messages: Cytoplasm
messages: Hydrolase that deubiquitinates target proteins such as FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:16111684, PubMed:16328052). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (By similarity). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (By similarity). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (By similarity). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (By similarity). Deubiquitinates KMT2E preventing KMT2E proteasomal-mediated degradation (By similarity). Involved in cell proliferation during early embryonic development (By similarity). Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (By similarity). Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (By similarity). Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (By similarity). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein …
messages: Monomer. Homodimer (PubMed:16111684). Part of a complex with DAXX, MDM2, RASSF1 and USP7. Part of a complex with DAXX, MDM2 and USP7. Interacts with MDM2; the interaction is independent of p53/TP53. Interacts with DAXX; the interaction is direct and independent of MDM2 and p53/TP53. Component of a complex composed of KMT2E, OGT and USP7; the complex stabilizes KMT2E, preventing KMT2E ubiquitination and proteasomal-mediated degradation (By similarity). Interacts (via MATH domain) with KMT2E (By similarity). Interacts with OGT (By similarity). Interacts with FOXO4; the interaction is enhanced in presence of hydrogen peroxide and occurs independently of p53/TP53. Interacts with p53/TP53; the interaction is enhanced in response to DNA damage; the interaction is impaired by TSPYL5. Interacts with PTEN; the interaction is direct. Interacts with ATXN1 and the strength of interaction is influenced by the length of the poly-Gln region in ATXN1. A weaker interaction seen with mutants having longer poly-Gln regions. Interacts with KIAA1530/UVSSA. Interacts with MEX3C and antagonizes its ability to degrade mRNA. Interacts with DNMT1 and UHRF1. Interacts with FOXP3. Interacts (via MATH domain) with RNF220 (By similarity). Associated component of the Polycomb group (PcG) multiprotein PRC1-like complex (By similarity). Interacts with EPOP (By similarity). Interacts with OTUD4 and USP9X; the interaction is direct (By similarity). Interacts with CRY2 (By similarity). Interacts with REST (By similarity). Interacts with ERCC6 (By similarity). Part of a complex consisting of USP7, MAGEL2 and TRIM27; directly interacts with MAGEL2; directly interacts with TRIM27 (By similarity).
messages: Not sumoylated.
messages: Nucleus
messages: PML body
messages: Polyneddylated.
messages: Strongly expressed in the testis, spleen and brain. Weakly expressed in the stomach, small intestine, skeletal muscle and uterus.
messages: The C-terminus plays a role in its oligomerization.
messages: Ubiquitinated at Lys-870 (By similarity). Polyubiquitinated.

10116:Flvcr2
gene id: 10116:Flvcr2
uniprot id: Q3T1I6
names: Subcellular Location Annotation
messages: Membrane

10116:Fam47e
gene id: 10116:Fam47e
uniprot id: A6KK67
names: Similarity
messages: Belongs to the FAM47 family.

10116:Pigp
gene id: 10116:Pigp
uniprot id: B2GUT8
uniprot id: F7FA59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGP family.
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

10116:Clta
gene id: 10116:Clta
uniprot id: A0A0G2JYW3
uniprot id: A0A8I6A7H3
uniprot id: A6IJ63
uniprot id: A6IJ64
uniprot id: P08081
uniprot id: Q5PPP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the clathrin light chain family.
messages: Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with CALY; the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis (By similarity). Interacts with CKAP5 and TACC3 forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; the complex implicates clathrin triskelions (By similarity).
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (By similarity).
messages: Cytoplasmic vesicle membrane
messages: coated pit
messages: spindle

10116:mrpl11
gene id: 10116:mrpl11
uniprot id: Q5XIE3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

10116:Upk1b
gene id: 10116:Upk1b
uniprot id: Q566D0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).
messages: Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).
messages: Membrane
messages: N-glycosylated with high-mannose oligosaccharides.

10116:Tmem98
gene id: 10116:Tmem98
uniprot id: A6HHC4
uniprot id: Q6AYS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM98 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1).
messages: Interacts (via N-terminal region) with MYRF; the interaction inhibits MYRF self-cleavage.
messages: Membrane
messages: Secreted
messages: extracellular exosome

10116:Nps
gene id: 10116:Nps
uniprot id: P0C0P7
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in mammary, salivary and thyroid gland. Expressed in the brain, in a cluster of cells located between the locus coeruleus (LC) and Barrington's nucleus, as well as in few cells of the dorsomedial hypothalamic nucleus and the amygdala.
messages: May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations.
messages: Secreted

10116:Pdcd6ip
gene id: 10116:Pdcd6ip
uniprot id: Q9QZA2
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in astrocytes and glioma cells.
messages: May be phosphorylated on tyrosine residues by activated PDGFRB.
messages: Melanosome
messages: Midbody ring
messages: Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (By similarity). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity).
messages: Self-associates (By similarity). Interacts with SH3KBP1 (PubMed:10858458). Interacts with PDCD6 in a calcium-dependent manner (By similarity). Interacts with TSG101 in a calcium-dependent manner; PDCD6IP homooligomerization may be required for TSG101-binding (By similarity). Interacts with SGSM3 (By similarity). Directly interacts with CHMP4A, CHMP4B and CHMP4C (By similarity). Directly interacts with CEP55 in a 1:2 stoechiometry; this interaction is required for PDCD6IP targeting to the midbody (By similarity). May interact with PDGFRB (By similarity). Interacts with SH3GL1 and SH3GL2/endophilin-1 (By similarity). Forms a complex with SDCBP and SDC2 (By similarity). Found in a complex with F-actin, TJP1/ZO-1 and PARD3 (By similarity). Interacts with CD2AP (By similarity). Interacts with ARRDC1 (By similarity).
messages: centrosome
messages: cytosol
messages: extracellular exosome
messages: tight junction

10116:Adat2
gene id: 10116:Adat2
uniprot id: B0BMY9
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

10116:Cdc5l
gene id: 10116:Cdc5l
uniprot id: B1WBQ0
uniprot id: O08837
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CEF1 family.
messages: By prolactin, IL-2 and FGF-2 in prolactin-dependent lymphoid cells (at protein level).
messages: Cytoplasm
messages: DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
messages: Homodimer. Interacts with DAPK3 (PubMed:11884640). Component of the precatalytic, catalytic and postcatalytic spliceosome complexes (By similarity). Part of a spliceosomal 'core' complex consisting of CDC5L, PLRG1, SPF27, CCAP1, CCAP3 and CCAP6. Interacts with PLRG1, Lodestar/TTF2, and NIPP1/PPP1R8 (PubMed:10827081). Identified in the spliceosome C complex. Component of the minor spliceosome, which splices U12-type introns. Within this complex, interacts with SCNM1 (By similarity). Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts (via its C-terminus) directly in the complex with PRPF19 and BCAS2. Interacts (via its C-terminus) directly with PRGL1 (via its WD40 repeat domain); the interaction is required for mRNA splicing but not for spliceosome assembly. Also interacts with CTNNBL1. Interacts with PRPF19 (via N-terminus) (PubMed:16352598). Interacts with USB1 (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2 (By similarity). Phosphorylation enhances interaction with PPP1R8.

10116:Mcpt8
gene id: 10116:Mcpt8
uniprot id: P97594
uniprot id: Q06606
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase S1 family. Granzyme subfamily.
messages: Cytoplasmic granule
messages: Duodenum, lung and spleen.
messages: Mast cells.
messages: Secreted
messages: This enzyme is necessary for target cell lysis in cell-mediated immune responses.

10116:Pou3f1
gene id: 10116:Pou3f1
uniprot id: A0A8I6GJZ5
uniprot id: P20267
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Neural tissues and testis.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). Acts as a transcriptional repressor of myelin-specific genes (PubMed:1975954).
messages: Transiently increased in rapidly dividing Schwann cells in response to sciatic nerve transection 2 days post-injury.

10116:Slc17a9
gene id: 10116:Slc17a9
uniprot id: A6KM79
uniprot id: D3ZUN1
uniprot id: P0DX21
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activity is chloride-dependent.
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
messages: Lysosome membrane
messages: Membrane
messages: Voltage-gated ATP nucleotide uniporter that can also transport the purine nucleotides ADP and GTP. Uses the membrane potential as the driving force to control ATP accumulation in lysosomes and secretory vesicles (PubMed:18375752). By controlling ATP storage in lysosomes, regulates ATP-dependent proteins of these organelles (By similarity). Also indirectly regulates the exocytosis of ATP through its import into lysosomes in astrocytes and secretory vesicles such as adrenal chromaffin granules, mucin granules and synaptic vesicles (PubMed:18375752).
messages: chromaffin granule membrane
messages: secretory vesicle membrane

10116:Snrnp200
gene id: 10116:Snrnp200
uniprot id: M3ZCQ2
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

10116:Or1j8b
gene id: 10116:Or1j8b
uniprot id: D3ZES4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Mrps27
gene id: 10116:Mrps27
uniprot id: A6I559
uniprot id: D4A3E8
names: Subcellular Location Annotation
messages: Mitochondrion

10116:Dpm1
gene id: 10116:Dpm1
uniprot id: A6JXN5
uniprot id: D4A8N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

10116:Vom2r48
gene id: 10116:Vom2r48
uniprot id: D3ZSU0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Fbln7
gene id: 10116:Fbln7
uniprot id: A6HQ40
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Xkr4
gene id: 10116:Xkr4
uniprot id: Q5GH59
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XK family.
messages: Cell membrane
messages: Homodimer; homodimerization takes place upon caspase cleavage. Interacts with the processed C-terminus of XRCC4 (protein XRCC4, C-terminus); interaction promotes the phospholipid scramblase activity.
messages: Homodimerizes upon caspase cleavage. Phospholipid scramblase activity is activated following interaction with the processed C-terminus of XRCC4 (protein XRCC4, C-terminus).
messages: Phospholipid scramblase activity is activated upon caspase cleavage to generate the XK-related protein 4, processed form. Does not act prior the onset of apoptosis.
messages: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment.
messages: Undergoes proteolytic processing by caspase-3 (CASP3), caspase-6 (CASP6) and caspase-7 (CASP7) to generate the XK-related protein 4, processed form, leading to its activation.

10116:Ttc29
gene id: 10116:Ttc29
uniprot id: Q6AYP3
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Axonemal protein which is implicated in axonemal and/or peri-axonemal structures assembly and regulates flagella assembly and beating and therefore sperm motility.
messages: The TPR repeats are required for proper localization into the axoneme and proper function in flagella beating and motility.
messages: flagellum axoneme

10116:Pde4c
gene id: 10116:Pde4c
uniprot id: A6KA07
uniprot id: G3V8J8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

10116:Sms
gene id: 10116:Sms
uniprot id: Q3MIE9
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

10116:Cul5
gene id: 10116:Cul5
uniprot id: A0A8I6ASH3
uniprot id: Q9JJ31
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cullin family.
messages: Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of CUL5, Elongin BC (ELOB and ELOC), RBX2 and a variable SOCS box domain-containing protein as substrate-specific recognition component. Component of the probable ECS(LRRC41) complex with the substrate recognition component LRRC41. Component of the probable ECS(SOCS1) complex with the substrate recognition component SOCS1. Component of the probable ECS(WSB1) complex with the substrate recognition subunit WSB1. Component of the probable ECS(SOCS3) complex with the substrate recognition component SOCS3. Component of the probable ECS(SPSB1) complex with the substrate recognition component SPSB1. Component of the probable ECS(SPSB2) complex with the substrate recognition component SPSB2. Component of the probable ECS(SPSB4) complex with the substrate recognition component SPSB4. Component of the probable ECS(RAB40C) complex with the substrate recognition subunit RAB40C. Component of the probable ECS(KLHDC1) complex with the substrate recognition component KLHDC1. May also form complexes containing CUL5, elongin BC complex (ELOB and ELOC), RBX1 and ELOA. May also form complexes containing CUL5, Elongin BC (ELOB and ELOC), RBX1 and VHL. Interacts with RNF7/RBX2, LRRC41, SOCS3, SPSB1, SPSB2, SPSB4 and RAB40C. Interacts with ASB1, ASB2, ASB6, ASB7 and ASB12. Interacts (when neddylated) with ARIH2; leading to activate the E3 ligase activity of ARIH1. Interacts with NOS2 in the presence of SPSB1 or SPSB2 or SPSB4. Interacts with ERCC6; the interaction is induced by DNA damaging agents or inhibitors of RNA polymerase II elongation. Interacts with ELOA (via the BC-box). Interacts (unneddylated form) with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5; these interactions promote the cullin neddylation. Component of the probable ECS(PCMTD1) complex with the substrate recognition subunit PCMTD1.
messages: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. ECS(KLHDC1) complex is part of the DesCEND (destruction via C-end degrons) pathway and mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine. As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A. May form a cell surface vasopressin receptor.
messages: Neddylated; which enhances the ubiquitination activity of SCF and prevents binding of the inhibitor CAND1. Deneddylated via its interaction with the COP9 signalosome (CSN).
messages: Nucleus

10116:Mrgprb13
gene id: 10116:Mrgprb13
uniprot id: Q7TN50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
messages: Membrane
messages: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).

10116:Parvb
gene id: 10116:Parvb
uniprot id: A0A0G2KB09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: Membrane

10116:Poll
gene id: 10116:Poll
uniprot id: A6JHI5
uniprot id: Q5RKI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Interacts with PCNA. Interacts with PAXX; promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end-filling activity of POLL. Interacts with XRCC4; promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end-filling activity of POLL. Interacts with NHEJ1/XLF; promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end-filling activity of POLL.
messages: Nucleus

10116:Or12j2
gene id: 10116:Or12j2
uniprot id: A0A0G2JTA8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Or1e1e
gene id: 10116:Or1e1e
uniprot id: A0A0A0MY21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Zer1
gene id: 10116:Zer1
uniprot id: A6JTV3
uniprot id: F1LQI6
names: Similarity
messages: Belongs to the zyg-11 family.

10116:Or13c7d
gene id: 10116:Or13c7d
uniprot id: A0A8I6AI10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Cldn10
gene id: 10116:Cldn10
uniprot id: A0A0G2JWU2
uniprot id: A6HUG8
uniprot id: A6HUG9
uniprot id: G3V7A9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

10116:Cdnf
gene id: 10116:Cdnf
uniprot id: A6JM11
uniprot id: P0C5I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted
messages: Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra.

10116:Olr56
gene id: 10116:Olr56
uniprot id: A0A0G2JUQ7
uniprot id: A6I767
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Antxr1
gene id: 10116:Antxr1
uniprot id: A0A0G2JSJ5
uniprot id: Q0PMD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATR family.
messages: Cell membrane
messages: Interacts with gelatin and type 1 collagen. Interacts with the actin cytoskeleton.
messages: Membrane
messages: Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
messages: filopodium membrane
messages: lamellipodium membrane

10116:Engase
gene id: 10116:Engase
uniprot id: A6HL61
uniprot id: D4AE03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 85 family.
messages: cytosol

10116:Rhbdf1
gene id: 10116:Rhbdf1
uniprot id: A6HDB3
uniprot id: Q499S9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S54 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer, or homooligomer. Interacts with TGFA and HBEGF. Interacts with EGF; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD). Interacts (via cytoplasmic N-terminus) with FRMD8/iTAP; this interaction leads to mutual protein stabilization. Interacts with ADAM17/TACE.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

10116:Cfhr1
gene id: 10116:Cfhr1
uniprot id: Q5I0M3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Pygb
gene id: 10116:Pygb
uniprot id: A6KHG6
uniprot id: P53534
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Activity of phosphorylase is controlled both by allosteric means (through the non-covalent binding of metabolites) and by covalent modification. Thus AMP allosterically activates, whereas ATP, ADP, and glucose-6-phosphate allosterically inhibit, phosphorylase B.
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Glycogen phosphorylase that regulates glycogen mobilization (By similarity). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
messages: Homodimer. Dimers associate into a tetramer to form the enzymatically active phosphorylase A.
messages: Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.

10116:Or1e26b
gene id: 10116:Or1e26b
uniprot id: A0A0G2K4J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Cxcl13
gene id: 10116:Cxcl13
uniprot id: Q5I0J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

10116:Or51a7b
gene id: 10116:Or51a7b
uniprot id: D3ZID6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Slc25a11
gene id: 10116:Slc25a11
uniprot id: P97700
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate (PubMed:5083502, PubMed:3355813, PubMed:7703504). Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity (PubMed:3355813, PubMed:7703504). Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (PubMed:5083502, PubMed:3355813). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (By similarity). Involved in the regulation of apoptosis (PubMed:16291728). Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria (PubMed:16291728).
messages: Expressed in liver, heart and brain.
messages: Mitochondrion inner membrane

10116:Slc16a10
gene id: 10116:Slc16a10
uniprot id: Q91Y77
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Not N-glycosylated.
messages: Sodium- and proton-independent thyroid hormones and aromatic acids transporter. Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (By similarity). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:11278508). Plays an important role in homeostasis of aromatic amino acids (By similarity).
messages: Strongly expressed in intestine, placenta and liver. In small intestine is detected in the basolateral membrane (at protein level).

10116:Flt1
gene id: 10116:Flt1
uniprot id: A6K197
uniprot id: A6K198
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.
messages: Membrane

10116:Med22
gene id: 10116:Med22
uniprot id: A0JPN6
uniprot id: A6JTI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 22 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).
messages: Nucleus

10116:Ski
gene id: 10116:Ski
uniprot id: A6IUN8
names: Similarity
messages: Belongs to the SKI family.

10116:Ngdn
gene id: 10116:Ngdn
uniprot id: A6KGY5
names: Subcellular Location Annotation
messages: nucleolus

10116:Stard9
gene id: 10116:Stard9
uniprot id: A0A0G2K9Y3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

10116:Apex2
gene id: 10116:Apex2
uniprot id: A1L132
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

10116:Irx1
gene id: 10116:Irx1
uniprot id: A6JUZ0
uniprot id: D4A9L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

10116:M6pr
gene id: 10116:M6pr
uniprot id: Q6AY20
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Binds GGA1, GGA2 and GGA3 (By similarity).
messages: Lysosome membrane
messages: The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor.
messages: This receptor has optimal binding in the presence of divalent cations.
messages: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex (By similarity).

10116:Rax
gene id: 10116:Rax
uniprot id: A6IXR9
uniprot id: Q9JLT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus
messages: Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter (By similarity).

10116:Syce1
gene id: 10116:Syce1
uniprot id: A6HXJ5
uniprot id: Q5XHZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYCE family.
messages: Chromosome
messages: Homodimer. Found in a complex with SYCP1 and SYCE2. Interacts with SYCP1, SYCE2 and SYCE3. Interacts with SIX6OS1.
messages: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination.
messages: Nucleus

10116:Prrt1
gene id: 10116:Prrt1
uniprot id: A6KTI9
uniprot id: Q6MG82
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CD225/Dispanin family.
messages: Cell membrane
messages: Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing.
messages: Expressed in the brain (at protein level) (PubMed:22632720, PubMed:26660156). In brain, expressed in the neocortex and enriched in the hippocampus but only modestly expressed in the cerebellum (PubMed:26660156). Expressed throughout the hippocampus but is most highly expressed in the CA1 region and the stratum lacunosum-moleculare of the CA2 region (PubMed:26660156).
messages: Expression is low at postnatal day 0, increases at postnatal day 7, peaks at postnatal days 14 and 21 and decreases at 2 months of age.
messages: Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function. Regulates basal AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses. Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression.
messages: Synapse

10116:Abcd1
gene id: 10116:Abcd1
uniprot id: D3ZHR2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed:12176987). Coupled to the ATP-dependent transporter activity has also a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process (By similarity). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:25043761). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Controls also the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (By similarity).
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Can form homodimers and heterodimers with ABCD2 and ABCD3. Dimerization is necessary to form an active transporter (PubMed:12176987, PubMed:25043761, PubMed:28258215). The minimal functional unit is a homodimer but the major oligomeric form in peroxisomal membrane is a homotetramer. Forms heterotramers with ABCD2 (PubMed:28258215). Interacts with PEX19; facilitates ABCD1 insertion into the peroxisome membrane (By similarity).
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Mitochondrion membrane
messages: Peroxisome membrane
messages: The NH2-terminal transmembrane domaine (TMD) is involved in the recognition of substrates, and undergoes a conformational change upon ATP binding to the COOH-terminal nucleotide binding domain (NBD).
messages: Tyrosine-phosphorylated.

10116:Pi4kb
gene id: 10116:Pi4kb
uniprot id: A0A8I6ALD3
uniprot id: A6K2T7
uniprot id: O08561
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Endomembrane system
messages: Golgi apparatus
messages: Golgi apparatus membrane
messages: Inhibited by wortmannin (PubMed:8973579). Increased kinase activity upon interaction with NCS1/FREQ (By similarity).
messages: Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6 (By similarity). Interacts with NCS1/FREQ in a calcium-independent manner. Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner; this interaction competes with NCS1/FREQ binding (PubMed:19458041). Interacts with ACBD3. Interacts with ARMH3, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN (By similarity). Interacts with GGA2 (via VHS domain); the interaction is important for PI4KB location at the Golgi apparatus membrane (By similarity). Interacts with ATG9A.
messages: Mitochondrion outer membrane
messages: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP) (PubMed:8973579). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (PubMed:8973579). May play an important role in the inner ear development.
messages: Rough endoplasmic reticulum membrane
messages: Strongly expressed in brain, kidney, lung, small intestine, uterus and adrenal gland. Weaker expression in liver, heart, skeletal muscle, thymus and testis. Not detected in spleen.

10116:Hal
gene id: 10116:Hal
uniprot id: A6IFY6
uniprot id: P21213
names: PTM
names: Similarity
names: Tissue Specificity
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.
messages: Liver and skin.

10116:Pdlim1
gene id: 10116:Pdlim1
uniprot id: P52944
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (By similarity). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (PubMed:22659164).
messages: Expressed most abundantly in heart, lung and liver, moderately in spleen and skeletal muscle, and at extremely low levels (if at all) in testis and brain tissues.
messages: Interacts with ACTN1 (PubMed:22659164). Interacts with ACTN2 and ACTN4 (By similarity). Interacts with PDLIM4 (PubMed:22659164).
messages: Z line
messages: cytoskeleton

10116:LOC689599
gene id: 10116:LOC689599
uniprot id: A6KF59
uniprot id: D4A8M8
names: Similarity
messages: Belongs to the themis family.

10116:Adh6
gene id: 10116:Adh6
uniprot id: A0A8I5ZLG2
uniprot id: A0A8I6ATS6
uniprot id: A0A8L2QGL3
uniprot id: Q5XI95
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alcohol dehydrogenase (By similarity). Catalyzes the NAD-dependent oxidation of primary alcohols to the corresponding aldehydes (By similarity). Oxidizes secondary alcohols to the corresponding ketones (By similarity).
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-V subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Dimer.

10116:Acaca
gene id: 10116:Acaca
uniprot id: P11497
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Consists of an N-terminal biotin carboxylation/carboxylase (BC) domain that catalyzes the ATP-dependent transient carboxylation of the biotin covalently attached to the central biotinyl-binding/biotin carboxyl carrier (BCC) domain. The C-terminal carboxyl transferase (CT) domain catalyzes the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA to produce malonyl-CoA.
messages: Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.
messages: Inhibited by phosphorylation (By similarity). Citrate promotes oligomerization of the protein into filaments that correspond to the most active form of the carboxylase (By similarity).
messages: Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity.
messages: Phosphorylation at Ser-79 by AMPK inactivates enzyme activity. Phosphorylated in vitro at Ser-1200 and Ser-1215 by AMPK; the relevance of phosphorylation of these sites in vivo is however unclear.
messages: Phosphorylation on Ser-1262 is required for interaction with BRCA1.
messages: The N-terminus is blocked.
messages: The biotin cofactor is covalently attached to the central biotinyl-binding domain and is required for the catalytic activity.
messages: cytosol

10116:Or51k2
gene id: 10116:Or51k2
uniprot id: A6I7C9
uniprot id: D4A084
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Emp1
gene id: 10116:Emp1
uniprot id: A6IMG6
uniprot id: P54848
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Most prominently found in the gastrointestinal tract, skin, lung, and brain but not in liver.

10116:Fam241a
gene id: 10116:Fam241a
uniprot id: A6HVM7
uniprot id: D4A9Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

10116:Gfra2
gene id: 10116:Gfra2
uniprot id: A0A8I6A8G6
uniprot id: F7FQ45
uniprot id: O35977
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.

10116:Fbxo7
gene id: 10116:Fbxo7
uniprot id: Q68FS3
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Mitochondrion
messages: Nucleus
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO7) formed of CUL1, SKP1, RBX1 and FBXO7. Interacts via its C-terminal proline-rich region with DLGAP5. Interacts with BIRC2. Interacts with CDK6 and promotes its interaction with D-type cyclin. Interacts (via the N-terminal Ubl domain) with PRKN. Interacts (via N-terminal region) with PINK1. Interacts with PSMF1 (By similarity).
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Recognizes and ubiquitinates BIRC2 and the cell cycle regulator DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. Mediates the ubiquitination and proteasomal degradation of UXT isoform 2, thereby impairing the NF-kappa-B signaling pathway. Inhibits NF-kappa-B pathway also by promoting the ubiquitinatioin of TRAF2 (By similarity). Affects the assembly state and activity of the proteasome in the cells including neurons by ubiquitinating the proteasomal subunit PSMA2 via 'Lys-63'-linked polyubiquitin chains (By similarity). Promotes 'Lys-48'-linked polyubiquitination SIRT7, leading to the hydrogen peroxide-induced cell death (By similarity).
messages: The proline-rich region is important for protein-protein interactions.
messages: The ubiquitin-like region mediates interaction with PRKN.
messages: cytosol

10116:Rnase12
gene id: 10116:Rnase12
uniprot id: Q5GAL8
uniprot id: W0UV69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Does not exhibit any ribonuclease activity.
messages: Secreted

10116:Kpna1
gene id: 10116:Kpna1
uniprot id: A0A0G2JXY5
uniprot id: Q56R20
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

10116:Kif23
gene id: 10116:Kif23
uniprot id: A0A8I6GJ20
uniprot id: A6J569
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

10116:Sobp
gene id: 10116:Sobp
uniprot id: A7XYI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SOBP family.
messages: Implicated in development of the cochlea.
messages: Interacts (via SIM domains) with SUMO1 and SUMO2.

10116:Cenpa
gene id: 10116:Cenpa
uniprot id: A6HAC7
uniprot id: F7EQM2
names: Similarity
messages: Belongs to the histone H3 family.

10116:Tubal3
gene id: 10116:Tubal3
uniprot id: A6JLQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

10116:Runx3
gene id: 10116:Runx3
uniprot id: Q91ZK1
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

10116:Mmp16
gene id: 10116:Mmp16
uniprot id: O35548
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 zinc ions per subunit.
messages: Cell membrane
messages: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. The short isoform efficiently converts progelatinase A to the intermediate form but not to the mature one. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
messages: Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.
messages: Strongly expressed in the lung, brain and smooth muscle cells. Weakly detectable in the spleen and liver and indetectable in the heart, skeletal muscle and kidney.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: The precursor is cleaved by a furin endopeptidase.
messages: extracellular matrix

10116:Tacc1
gene id: 10116:Tacc1
uniprot id: A0A0G2K9K2
uniprot id: A0A8I5Y233
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: centrosome

10116:Or13l2
gene id: 10116:Or13l2
uniprot id: A6K3B3
uniprot id: D3ZSW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ormdl1
gene id: 10116:Ormdl1
uniprot id: A0A8I5ZW96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane

10116:Dus3l
gene id: 10116:Dus3l
uniprot id: Q3KRC5
names: Function
names: Similarity
messages: Belongs to the Dus family. Dus3 subfamily.
messages: Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs. Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation.

10116:LOC314140
gene id: 10116:LOC314140
uniprot id: A0A0G2JSV3
uniprot id: P60892
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by magnesium and inorganic phosphate.
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity).
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

10116:Nqo2
gene id: 10116:Nqo2
uniprot id: Q6AY80
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
messages: Uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor.

10116:Ciao2a
gene id: 10116:Ciao2a
uniprot id: A6J5H6
uniprot id: F7EXH6
names: Similarity
messages: Belongs to the MIP18 family.

10116:Pick1
gene id: 10116:Pick1
uniprot id: A6HSQ7
uniprot id: Q9EP80
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed early in development (15 dpc), and gradually increases, reaching a peak at around 2 weeks after birth.
messages: Membrane
messages: Monomer and homodimer. Interacts with CXADR. Interacts presynaptically with the glutamate receptors GRIA2, GRIA3, GRIK3, isoform 3 of GRIA4, isoform A of GRM4, GRM7 and GRM8; with NAPA and NAPB; and with BTG2. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with PRKCA; with the amine transporters SLC6A2 and SLC6A3; with the channels ASIC1 and ASIC2; with the GTP-binding proteins ARF1 and ARF3; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; with ERBB2 and through its PDZ domain with the C-terminal tail of PRLHR (By similarity). Interacts with UNC5A. Interacts (via AH domain) with NCS1/FREQ; in a calcium-dependent manner. Interacts with F-actin and associates with the ARP2/3 complex. Interacts (via PDZ domain) with ARF1 (activated); the interaction blocks Arp2/3 complex inhibition.
messages: Palmitoylation on Cys-414 is essential for long-term synaptic depression (LTD).
messages: Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.
messages: Postsynaptic density
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: The AH domain mediates binding to F-actin.
messages: The unoccupied PDZ domain is probably involved in allosteric modulation by forming an intramolecular bridge with the AH domain leading to a 'closed' formation. Binding of a PDZ ligand, such as GRIA2, allows enhanced interactions with F-actin and the Arp2/3 complex thus enhanced inhibition of actin polymerization.
messages: Ubiquitous.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

10116:Tfr2
gene id: 10116:Tfr2
uniprot id: B2GUY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation (By similarity).

10116:Il36a
gene id: 10116:Il36a
uniprot id: A6JSX7
uniprot id: D4A1I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

10116:Or13a27d
gene id: 10116:Or13a27d
uniprot id: A0A8I6G966
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:RT1-S3
gene id: 10116:RT1-S3
uniprot id: F1LQF2
uniprot id: Q9QUQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Membrane

10116:Pdha1
gene id: 10116:Pdha1
uniprot id: Q4FZZ4
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

10116:Kpna2
gene id: 10116:Kpna2
uniprot id: F7F4Z2
uniprot id: Q6P6T9
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

10116:Smarca2
gene id: 10116:Smarca2
uniprot id: Q6DUH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

10116:Eps8l3
gene id: 10116:Eps8l3
uniprot id: A6HUV5
uniprot id: M0R3R8
names: Similarity
messages: Belongs to the EPS8 family.

10116:Nek8
gene id: 10116:Nek8
uniprot id: D3ZGQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
messages: Cytoplasm
messages: Interacts with PKD2; may regulate PKD2 targeting to the cilium (By similarity). Component of a complex containing at least ANKS6, INVS, NEK8 and NPHP3 (PubMed:23793029). ANKS6 may organize complex assembly by linking INVS and NPHP3 to NEK8 and INVS may target it to the proximal ciliary axoneme (PubMed:23793029). Interacts with ANKS3 (By similarity).
messages: Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway (By similarity).
messages: centrosome
messages: cilium
messages: cytoskeleton

10116:Msh5
gene id: 10116:Msh5
uniprot id: A0A0H2UI03
uniprot id: Q6MG62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family.
messages: Heterooligomer of MSH4 and MSH5. Interacts with HJURP (By similarity).
messages: Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity).

10116:Ccdc32
gene id: 10116:Ccdc32
uniprot id: Q561K4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with AP2S1; the interaction is direct and mediates association with adaptor protein complex 2 (AP-2).
messages: Regulates clathrin-mediated endocytsois of cargos such as transferrin probably through the association and modulation of adaptor protein complex 2 (AP-2) (By similarity). Has a role in ciliogenesis (By similarity). Required for proper cephalic and left/right axis development (By similarity).
messages: coated pit

10116:Spaca5
gene id: 10116:Spaca5
uniprot id: A6JZP9
uniprot id: M0RCC1
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

10116:Defb14
gene id: 10116:Defb14
uniprot id: A6IWA4
uniprot id: Q32ZH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

10116:Or2ak6e
gene id: 10116:Or2ak6e
uniprot id: M0RAV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Chrm5
gene id: 10116:Chrm5
uniprot id: A6HP54
uniprot id: P08911
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

10116:Crybb1
gene id: 10116:Crybb1
uniprot id: A6J266
uniprot id: P02523
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.
messages: Specific cleavages in the N-terminal arm occur during lens maturation and give rise to truncated forms, leading to impaired oligomerization and protein insolubilization. The protease responsible for this partial degradation could be calpain II.

10116:Anapc10
gene id: 10116:Anapc10
uniprot id: A6IYH7
uniprot id: F7EP70
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

10116:LOC297568
gene id: 10116:LOC297568
uniprot id: A0A0G2K926
uniprot id: A6ILD3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Monomer.
messages: Secreted

10116:Cbr4
gene id: 10116:Cbr4
uniprot id: Q7TS56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro).
messages: Homotetramer (in vitro). Heterotetramer with HSD17B8; contains two molecules each of HSD17B8 and CBR4. Does not form homotetramers when HSD17B8 is coexpressed, only heterotetramers (in vitro).
messages: Mitochondrion matrix

10116:Mfsd14a
gene id: 10116:Mfsd14a
uniprot id: A6HVA5
uniprot id: F7F1C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

10116:Olr1696
gene id: 10116:Olr1696
uniprot id: A0A8I6ANN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Eef2k
gene id: 10116:Eef2k
uniprot id: A6I8S8
uniprot id: P70531
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated at multiple residues, Thr-347 being the major site. Phosphorylated by AMP-activated protein kinase AMPK at Ser-397 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at Ser-77 resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of protein synthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-358 or RPS6KA1 and RPS6KB1 at Ser-365 instead decrease EEF2K activity and promote protein synthesis (By similarity).
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
messages: Monomer or homodimer (Probable). Interacts with Calmodulin/CALM1; this interaction is strictly required for phosphorylation activity (By similarity).
messages: Monomer or homodimer.
messages: The N-terminus is blocked.
messages: Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced (By similarity).
messages: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.
messages: Widely expressed, with high levels in reticulocytes and skeletal muscle.

10116:Cmpk2
gene id: 10116:Cmpk2
uniprot id: A6HB00
names: Similarity
messages: Belongs to the thymidylate kinase family.

10116:Trim46
gene id: 10116:Trim46
uniprot id: A0A5H1ZRV2
names: Subcellular Location Annotation
messages: cytoskeleton

10116:Cldn5
gene id: 10116:Cldn5
uniprot id: A6JSE9
uniprot id: Q9JKD6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). Interacts with MPDZ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: Plays a major role in tight junction-specific obliteration of the intercellular space.
messages: tight junction

10116:Tax1bp1
gene id: 10116:Tax1bp1
uniprot id: Q66HA4
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homooligomer. Interacts with TNFAIP3. Interacts with STARD13. Interacts with MYO6. Interacts with TOM1; the interaction is indirect and is mediated by MYO6, which acts as a bridge between TOM1 and TAX1BP1. Interacts with MAVS; this interaction induces MAVS polyubiquitination. Interacts with TNIP1. Interacts with TRAF6; this interaction mediates deubiquitination of TRAF6 and inhibition of NF-kappa-B activation. Interacts with RIPK1; this interaction negatively regulates RIPK1 ubiquitination. Interacts with NBR1. Interacts with TBK1. Interacts with RB1CC1. Interacts with SQSTM1. Interacts with AZI2.
messages: Mitochondrion
messages: Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation.
messages: Preautophagosomal structure
messages: The C-terminal UBZ-type zinc fingers function as ubiquitin-binding domains.
messages: Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation. Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates. Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production. Recruits also A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways. Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling. As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis. Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation.
messages: autophagosome

10116:Ddrgk1
gene id: 10116:Ddrgk1
uniprot id: A6HQA5
uniprot id: D3ZAS9
names: Similarity
messages: Belongs to the DDRGK1 family.

10116:Amigo1
gene id: 10116:Amigo1
uniprot id: A6HUY4
uniprot id: Q80ZD7
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: By HMGB1/amphoterin; in cultured hippocampal neurons.
messages: Cell membrane
messages: Expressed at moderate levels in the central nervous system of stage 13-14 embryos. Highest levels at this stage in fiber tracts from dorsal root ganglia and trigeminal ganglion to the spinal cord as well as in fibers on both sides of the Purkinje cell layer of the cerebellum. Expression is down-regulated during postnatal stages P6 to P10 followed by up-regulation at the onset of myelination. High level expression in most myelinated axon tracts of the adult including cerebellum, pons, medulla, and spinal cord as well as in nonmyelinated fiber tracts in the striatum lucidum CA3 region of the hippocampus.
messages: Homodimer, and heterodimer with AMIGO2 and AMIGO3 (PubMed:12629050). Interacts with KCNB1 (By similarity).
messages: Membrane
messages: Perikaryon
messages: Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (PubMed:12629050). Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity).
messages: The LRR repeat region mediates homodimerization.
messages: axon
messages: dendrite

10116:Tdrd3
gene id: 10116:Tdrd3
uniprot id: Q66HC1
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of mRNA stress granules. Interacts with FMR1, FXR1, FXR2, EWSR1, FUS, SERBP1, EEF1A1 and DDX3X or DDX3Y, and with the small nuclear ribonucleoprotein-associated proteins SNRPB and SNRPN. Interacts with 'Lys-48'-linked tetra-ubiquitin, but not with monoubiquitin or 'Lys-63'-linked ubiquitin chains. May interact with the exon junction complex (EJC) composed at least of CASC3, EIF4A3, MAGOH and RBM8A. Interacts with POLR2A (via the C-terminal domain (CTD)).
messages: Cytoplasm
messages: Nucleus
messages: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1.
messages: The Tudor domain specifically recognizes and binds asymmetric dimethylation of histone H3 'Arg-17' (H3R17me2a) and histones H4 'Arg-3', 2 tags for epigenetic transcriptional activation.

10116:Plekhf1
gene id: 10116:Plekhf1
uniprot id: Q68FU1
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Lysosome
messages: May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8 (By similarity).
messages: Nucleus
messages: PH and FYVE-type zinc finger domains are required for lysosomal location.
messages: perinuclear region

10116:Dbndd2
gene id: 10116:Dbndd2
uniprot id: A6JX90
uniprot id: A6JX91
names: Similarity
messages: Belongs to the dysbindin family.

10116:Chrng
gene id: 10116:Chrng
uniprot id: P18916
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Gamma/CHRNG sub-subfamily.
messages: Cell membrane
messages: Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.
messages: Postsynaptic cell membrane

10116:Phlpp1
gene id: 10116:Phlpp1
uniprot id: Q9WTR8
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds 2 manganese ions per subunit.
messages: Cell membrane
messages: Cytoplasm
messages: In the suprachiasmatic nucleus, it increases during subjective night with a peak at midnight under constant dark conditions. Expressed at a constant level in neurons throughout the brain (at protein level) (PubMed:10570941). Isoform 2 expression increases over development and maturation in the hippocampus. Isoform 1 expression is low in embryonic stages, increases during postnatal development and is falling back to low embryonic levels in adulthood (PubMed:20819118).
messages: Inhibited by insulin in a PI3K-dependent manner.
messages: Insensitive to okadaic acid. Deubiquitination by WDR48-USP12 complex positively regulates PHLPP1 stability.
messages: Interacts with the nucleotide free form of K-Ras (KRAS) via its LRR repeats (PubMed:12594205). Interacts with AKT2, AKT3 and PRKCB isoform beta-II. Interacts with WDR48 and USP12 (By similarity).
messages: Mainly present in brain (at protein level) (PubMed:10570941). Isoform 2 is more abundant in adult brain neurons than isoform 1 in (PubMed:20819118). Isoforms 1 and 2 are expressed in the retina but not found in rod outer segments (PubMed:20089132).
messages: Membrane
messages: Nucleus membrane
messages: Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:20819118). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons while isoform 1 may promote Akt and PKC activation and inhibit ERK signaling (PubMed:20819118). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (By similarity). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (By similarity). Inhibits cancer cell proliferation and may act as a tumor suppressor (By similarity). Dephosphorylates RAF1 inhibiting its kinase activity (By similarity). May act as a negative regulator of K-Ras signaling in membrane rafts (PubMed:12594205). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity).
messages: The PH domain is required for interaction with PRKCB and its dephosphorylation.
messages: nucleoplasm

10116:Nlgn2
gene id: 10116:Nlgn2
uniprot id: Q62888
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Detected on hippocampus neurons, especially at inhibitory synapses. Detected in retina, in the outer and inner plexiform layer. Detected in pancreas, in islet of Langerhans beta cells (at protein level). Expressed in brain, spinal cord and dorsal root ganglion. Detected in brain, and at lower levels in pancreas islet beta cells.
messages: Interacts with neurexins NRXN1, NRXN2 and NRXN3 (PubMed:8576240, PubMed:18334216, PubMed:20624592). Interaction with neurexins is mediated by heparan sulfate glycan modification on neurexin (By similarity). Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3) (By similarity). Interacts with PATJ (PubMed:9647694). Interacts with GPHN (PubMed:19755106). Interacts with MDGA1 and MDGA2 (PubMed:23248271). Found in a complex with MAGI2 and IGSF9B, where it interacts with MAGI2 (via WW 1, WW 2 and PDZ 2 domains) (PubMed:23751499). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (PubMed:28279354). Interacts with LHFPL4; leading to mutual regulation of the protein level and synaptic clustering (PubMed:29742426, PubMed:28279354). Interacts with GABRA1 (PubMed:28279354).
messages: Postsynaptic cell membrane
messages: Presynaptic cell membrane
messages: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion.

10116:Vom2r79
gene id: 10116:Vom2r79
uniprot id: F1M1H4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Hspa8
gene id: 10116:Hspa8
uniprot id: A6J3Q9
uniprot id: P63018
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated.
messages: Belongs to the heat shock protein 70 family.
messages: Cell membrane
messages: Constitutively synthesized.
messages: Cytoplasm
messages: ISGylated.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (By similarity). Interacts with PACRG (By similarity). Interacts with HSPH1/HSP105 (By similarity). Interacts with IRAK1BP1 and BAG1 (By similarity). Interacts with DNAJC7 (PubMed:10567422). Interacts with DNAJB12 (via J domain) (By similarity). Interacts with DNAJB14 (via J domain) (By similarity). Interacts (via C-terminus) with the E3 ligase STUB1 forming a 210 kDa complex of one STUB1 and two HSPA8 molecules (By similarity). Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation (By similarity). Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8 (By similarity). Interacts with TRIM5 (By similarity). Part of a complex composed at least of ASH2L, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (By similarity). Interacts with METTL21A (By similarity). Following LPS binding, may form a complex with CXCR4, GDF5 and HSP90AA1 (By similarity). Interacts with PRKN (By similarity). Interacts with FOXP3 (By similarity). Interacts with DNAJC9 (via J domain) (By similarity). Interacts with MLLT11 (By similarity). Interacts with RNF207 (By similarity). Interacts with DNAJC21 (By similarity). Interacts with DNAJB2 (By similarity). Interacts with TTC1 (via TPR repeats) (By similarity). Interacts with SGTA (via TPR repeats) (PubMed:15708368). Interacts with HSF1 (via transactivation domain) (By similarity). Interacts with HOPX, STUB1, HSP40, HSP90, BAG2 and BAG3 (By similarity). Interacts with DNAJC12 (By similarity). Interacts with HSPC138 (By similarity). Interacts with ZMYND10 (By similarity). Interacts with VGF-derived peptide TLQP-21 (By simila…
messages: Lysosome membrane
messages: Melanosome
messages: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for…
messages: The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
messages: Trimethylation at Lys-561 reduces fibrillar SNCA binding.
messages: nucleolus

10116:Gpr83
gene id: 10116:Gpr83
uniprot id: Q8VHD7
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed preferentially in brain, and its neuronal expression is relegated to limbic brain regions, particularly in forebrain.
messages: G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN. Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors.
messages: Increased in the prefrontal cortex of rat chronically treated with amphetamines.
messages: NPY has been reported to be a ligand for GPR83 (PubMed:17240481). However, a more recent study found that radiolabeled PEN binding to GPR83 is not affected by NPY concentrations below 1 mM, only very high, non-physiological concentrations causes a partial, displacement of PEN binding (By similarity).

10116:Phf20
gene id: 10116:Phf20
uniprot id: A6KIA1
uniprot id: D3ZQB7
names: Subcellular Location Annotation
messages: Nucleus

10116:Spock1
gene id: 10116:Spock1
uniprot id: A6KAL9
uniprot id: Q562B0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Slc6a5
gene id: 10116:Slc6a5
uniprot id: P58295
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A5 subfamily.
messages: Cell membrane
messages: N-glycosylated.
messages: Sodium- and chloride-dependent glycine transporter (PubMed:8226790, PubMed:25480793). Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals (PubMed:8226790). May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses (PubMed:8226790).
messages: Specifically expressed in spinal cord, brain stem, and to a lesser extent in the cerebellum.

10116:Afg3l2
gene id: 10116:Afg3l2
uniprot id: F1LN92
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

10116:Pard6g
gene id: 10116:Pard6g
uniprot id: A3F6Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

10116:Ugt2b
gene id: 10116:Ugt2b
uniprot id: Q5EBC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

10116:Cpa4
gene id: 10116:Cpa4
uniprot id: A6IEG9
uniprot id: D3ZHS5
names: Similarity
messages: Belongs to the peptidase M14 family.

10116:En2
gene id: 10116:En2
uniprot id: A6KJL2
uniprot id: D3Z8B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

10116:Jpt1
gene id: 10116:Jpt1
uniprot id: A0A059NZR0
uniprot id: Q6AXU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Interacts with the complex composed, at least, of APC, CTNNB1 and GSK3B; the interaction takes place with the inactive form of GSK3B (phosphorylated at 'Ser-9').
messages: Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation.
messages: Nucleus

10116:Aldh6a1
gene id: 10116:Aldh6a1
uniprot id: A6JDW8
uniprot id: G3V7J0
uniprot id: Q02253
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Expressed in the head and flagellum of epididymal sperm but not in testicular sperm (at protein level). Kidney > liver > heart > muscle > brain.
messages: Homotetramer.
messages: Malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine.
messages: Mitochondrion
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

10116:Atg5
gene id: 10116:Atg5
uniprot id: Q5XIS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

10116:Galnt18
gene id: 10116:Galnt18
uniprot id: A1A5P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

10116:Jarid2
gene id: 10116:Jarid2
uniprot id: A6J730
uniprot id: A6J732
uniprot id: M0RBV7
names: Subcellular Location Annotation
messages: Nucleus

10116:Clic5
gene id: 10116:Clic5
uniprot id: A6JJ16
uniprot id: Q9EPT8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the chloride channel CLIC family.
messages: Component of a multimeric complex consisting of several cytoskeletal proteins, including actin, ezrin, alpha-actinin, gelsolin, and IQGAP1.
messages: Cytoplasm
messages: Detected in cochlea, in cochlear and vestibular hair cell bundles in the organ of Corti (at protein level) (PubMed:17021174). Expressed neonatal and adult cardiomyocytes (at protein level) (PubMed:26777142).
messages: Golgi apparatus
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Mitochondrion
messages: Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens.
messages: cell cortex
messages: centrosome
messages: cytoskeleton

10116:Def8
gene id: 10116:Def8
uniprot id: A6IZY4
uniprot id: Q4V8I4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DEF8 family.
messages: Interacts (via C-terminus) with PLEKHM1; this interaction is weak but increased in a RAB7A-dependent manner.
messages: Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption.

10116:Eif3f
gene id: 10116:Eif3f
uniprot id: D4AC36
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

10116:Ppp1r3b
gene id: 10116:Ppp1r3b
uniprot id: A6IVM9
uniprot id: Q6IN01
names: Domain
names: Function
names: Subunit
names: Tissue Specificity
messages: Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes.
messages: Highly expressed in liver. Moderately expressed in kidney, heart, testis, spleen and lung. Weakly expressed in skeletal muscle (at protein level). Expressed predominantly in liver. Expressed moderately in heart. Expressed weakly in lung, kidney, spleen and skeletal muscle.
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The PP1-binding domain is located between residues 59 and 94. The glycogen-binding domain is located between residues 94 and 257. The PYGL-binding site lies in the C-terminal 16 amino acids.

10116:Dhx58
gene id: 10116:Dhx58
uniprot id: D3ZD46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

10116:Ppp3cc
gene id: 10116:Ppp3cc
uniprot id: E2CWF0
uniprot id: E2CWF1
uniprot id: Q6AYJ0
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

10116:Nsg2
gene id: 10116:Nsg2
uniprot id: Q3KR51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSG family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi stack membrane
messages: Late endosome membrane
messages: Lysosome lumen
messages: Membrane
messages: dendrite
messages: multivesicular body membrane
messages: trans-Golgi network membrane

10116:Sult1c2
gene id: 10116:Sult1c2
uniprot id: Q9WUW8
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sulfotransferase 1 family.
messages: Cytoplasm
messages: Down-regulated in kidney but not in stomach following feeding with 2-amino-4,5-diphenylthiazole.
messages: Highly expressed in kidney and at lower levels in stomach and liver. More specifically found in the epithelia of proximal tubules of the kidney, of the bile duct, of the gastric mucosa, and in hepatocytes.
messages: Lysosome
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Sulfonates p-nitrophenol, a small phenolic compond. Does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol.

10116:Spsb1
gene id: 10116:Spsb1
uniprot id: A0A0G2K863
uniprot id: A6IUC3
names: Similarity
messages: Belongs to the SPSB family.

10116:Strap
gene id: 10116:Strap
uniprot id: Q5XIG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat STRAP family.
messages: Cytoplasm
messages: Nucleus
messages: Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts directly with GEMIN6 and GEMIN7. Associates with the SMN complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1. Interacts with TRIM48.
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein (By similarity).

10116:Shfl
gene id: 10116:Shfl
uniprot id: A0A140TAE2
uniprot id: A6JNL7
uniprot id: Q5RJN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHFL family.
messages: Cytoplasm
messages: Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses and cellular genes. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site. May exhibit antiviral activity.
messages: Interacts with PABPC1. Found in a complex with PABPC1 and LARP1. Interacts with ELAV1, MOV10 and UPF1; the interactions increase in presence of RNA. Binds to ribosomes. Interacts with GSPT1.
messages: Nucleus
messages: P-body

10116:Snf8
gene id: 10116:Snf8
uniprot id: A6HIC5
uniprot id: Q5RK19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome membrane
messages: Interacts with TSG101 (via the C-terminal domain). Interacts with RILPL1 (via the N-terminal domain); which recruits ESCRT-II to the endosome membranes. Interacts with 14-3-3 proteins (By similarity). Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS25 and VPS36 (PubMed:11278625). SNF8 is essential for the stability of the ESCRT-II complex. ESCRT-II interacts with ELL (By similarity).
messages: Late endosome membrane
messages: Nucleus
messages: Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization (By similarity). Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL.Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).

10116:Marchf7
gene id: 10116:Marchf7
uniprot id: Q5XI50
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (By similarity).
messages: The RING-CH-type zinc finger domain is required for E3 ligase activity.

10116:Gabrq
gene id: 10116:Gabrq
uniprot id: A6KSY1
uniprot id: G3V875
uniprot id: Q91ZM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

10116:Rac1
gene id: 10116:Rac1
uniprot id: Q6RUV5
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Cytoplasm
messages: GTP-bound active form is ubiquitinated by HACE1, leading to its degradation by the proteasome.
messages: Interacts with NISCH. Interacts with PIP5K1A. Interacts with the GTP-bound form of RAB7A. Interacts with SRGAP2. Interacts with CYFIP1/SRA-1. Interacts with PLXNB3. Interacts with ARHGDIA; the interaction is induced by SEMA5A, mediated through PLXNB3 and inactivates and stabilizes RAC1. Interacts (GTP-bound form preferentially) with PKN2 (via the REM repeats); the interaction stimulates autophosphorylation and phosphorylation of PKN2. Interacts with the GEF proteins PREX1, RASGRF2, FARP1, FARP2, DOCK1, DOCK2 and DOCK7, which promote the exchange between GDP and GTP, and therefore activate it. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ), which plays a central role in epithelial cell polarization. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Interacts with RALBP1 via its effector domain. Interacts with PLXNB1. Part of a complex with MAP2K3, MAP3K3, CCM2 and DEF6. Interacts with BAIAP2, BAIAP2L1 and DEF6. Interacts with Y.pseudotuberculosis YPKA and PLCB2. Interacts with NOXA1. Interacts with ARHGEF2. Interacts with TBC1D2. Interacts with UNKL. Interacts with USP6. Interacts with SPATA13. Interacts with ARHGEF16; mediates activation of RAC1 by EPHA2. Interacts with ITGB4. Interacts with S100A8 and calprotectin (S100A8/9). Interacts with PACSIN2. Interacts with ITGB1BP1. Interacts (when active) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane. Interacts with RAPH1 (via Ras associating and PH domains) (By similarity). Interacts with MTSS2 (via IMD domain); this interaction may be important to potentiate PDGF-induced RAC1 activation. Interacts with PAK2. Interacts (GTP-bound form) with SH3RF1 and SH3RF3. Found in a complex with SH3RF1, MAPK8IP1/JIP1, MAP3K11/MLK3, MAP2K7/MKK7 …
messages: Melanosome
messages: Nucleus
messages: Osteoclasts.
messages: Phosphorylated by AKT at Ser-71.
messages: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles (PubMed:16040606, PubMed:16549782). Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity (By similarity). In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (PubMed:16040606). In glioma cells, promotes cell migration and invasion (PubMed:20696765). In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning (PubMed:19029984). Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). In neurons, is involved in dendritic spine formation and synaptic plasticity (PubMed:25498153). In hippocampal neurons, involved in spine morphogenesis and synapse formation, through local activation at synapses by guanine nucleotide exchange factors (GEFs), such as ARHGEF6/ARHGEF7/PIX (PubMed:12695502). In synapses, may mediate the regulation of F-actin cluster formation performed by SHANK3 (PubMed:24089484). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization (PubMed:25284783).
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. GTP hydrolysis is stimulated by ARHGAP30 and ARHGAP44.
messages: Synapse
messages: The effector region mediates interaction with DEF6.
messages: Ubiquitinated at Lys-166 in a FBXL19-mediated manner; leading to proteasomal degradation.
messages: dendrite
messages: lamellipodium

10116:Trappc3l
gene id: 10116:Trappc3l
uniprot id: D3ZEX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

10116:Olr1675
gene id: 10116:Olr1675
uniprot id: A0A8I5ZZ32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Scn3b
gene id: 10116:Scn3b
uniprot id: A6J3Q2
uniprot id: Q9JK00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Expressed broadly in neurons in the central and peripheral nervous systems, but not in glia and most non-neuronal cells. Weak detection in lung and adrenal gland.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
messages: The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds. Beta-1 or beta-3 subunits associate with NFASC. Associates with SCN10A.

10116:Usp15
gene id: 10116:Usp15
uniprot id: A0A0A0MY07
uniprot id: A6HQN9
uniprot id: Q9R085
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A homodimer structure has been reported; however it is unclear whether the protein form a homodimer in vivo. Identified in a complex with the COP9 signalosome complex (CSN). Interacts with SMAD1, SMAD2 and SMAD3; the interaction is direct. Forms a complex with SMURF2 and SMAD7. Interacts with TGFBR1. Interacts with SART3; the interaction is direct. May interact with RNF20 and RNF40. May interact with PRKN. Interacts with INCA1.
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Highly expressed in testis and spleen, and at lower level in other tissues.
messages: Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal. Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B. Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy. Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery. Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9.
messages: Mitochondrion
messages: Nucleus
messages: Phosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome.
messages: Ubiquitinated, leading to degradation by the proteasome.

10116:Pgm1
gene id: 10116:Pgm1
uniprot id: A0A8I6AV00
uniprot id: A6JRM5
uniprot id: F7F2L9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

10116:Tacr1
gene id: 10116:Tacr1
uniprot id: A6IAH6
uniprot id: P14600
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane
messages: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

10116:Slc28a1
gene id: 10116:Slc28a1
uniprot id: Q62674
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Cell membrane
messages: Due to its high apparent affinity but slow transport, adenosine could act as a negative regulator of pyrimidine transport under some conditions.
messages: Expressed predominantly in the brush-border membranes of the polarized epithelial cells of jejunum and renal cortical tubules and in the bile canalicular membranes of liver parenchymal cells.
messages: N-glycosylated. N-glycosylation is required for localization to the plasma membrane and the transporter activity.
messages: Sodium and pyrimidine nucleoside symporter of the plasma membrane that imports uridine, thymidine and cytidine into cells by coupling their transport to the transmembrane sodium electrochemical gradient. Also transports adenosine, an atypical substrate transported with high apparent affinity, but low maximum velocity. Therefore, exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (PubMed:8027026, PubMed:8967974). Involved in renal nucleoside (re)absorption (By similarity).

10116:Trmt11
gene id: 10116:Trmt11
uniprot id: Q7TNK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
messages: Interacts with TRMT112.

10116:Slc27a6
gene id: 10116:Slc27a6
uniprot id: A6IX92
uniprot id: D4A2B8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

10116:Fscb
gene id: 10116:Fscb
uniprot id: Q4V7A4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CABYR.
messages: May be involved in the later stages of fibrous sheath biogenesis. Binds calcium (By similarity).
messages: flagellum

10116:Endou
gene id: 10116:Endou
uniprot id: D3ZSZ1
names: Similarity
names: Subunit
messages: Belongs to the ENDOU family.
messages: Monomer.

10116:Cenpm
gene id: 10116:Cenpm
uniprot id: A6HT51
uniprot id: D4AC25
names: Subcellular Location Annotation
messages: Nucleus

10116:Rad51b
gene id: 10116:Rad51b
uniprot id: A6HCH3
names: Subcellular Location Annotation
messages: Nucleus

10116:Olr1143
gene id: 10116:Olr1143
uniprot id: A0A8I6AP05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Egf
gene id: 10116:Egf
uniprot id: P07522
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).
messages: Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD) (By similarity). Interacts with RHBDF2 (By similarity).
messages: Membrane

10116:Hlf
gene id: 10116:Hlf
uniprot id: A0A8I6APH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

10116:Pth2
gene id: 10116:Pth2
uniprot id: A6JAZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Secreted

10116:Tas2r119
gene id: 10116:Tas2r119
uniprot id: A6JN06
uniprot id: Q9JKU1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in the duodenum, antrum and fundus (part of the stomach).
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
messages: Membrane
messages: Several bitter taste receptors are expressed in a single taste receptor cell.

10116:Cep41
gene id: 10116:Cep41
uniprot id: Q4KM37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CEP41 family.
messages: Found in a complex with TTLL6.
messages: Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium (By similarity).
messages: centrosome
messages: cilium
messages: cilium basal body

10116:Adssl1
gene id: 10116:Adssl1
uniprot id: A6KBV5
uniprot id: M0R629
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

10116:Cdr2l
gene id: 10116:Cdr2l
uniprot id: A6HKM0
uniprot id: D4ABP3
names: Similarity
messages: Belongs to the CDR2 family.

10116:Galnt13
gene id: 10116:Galnt13
uniprot id: A0A8I6GB66
uniprot id: A6JF40
uniprot id: Q6UE39
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine (GalNAc) residue from UDP-GalNAc to a serine or threonine residue on the protein receptor (By similarity). Generates GalNAc-O-Ser/Thr structure also known as Tn antigen, which itself is immunogenic but also serves as a precursor for the synthesis of different mucin-type O-glycan core structures (By similarity). Contributes to the synthesis of O-linked glycans on mucins and proteoglycans of the central nervous system (By similarity). Can glycosylate both unmodified peptides and glycopeptides that already contain an O-linked GalNAc sugar. Transfers GalNAc to Thr-/Ser-rich tandem repeats GTTPSPVPTTSTTSAP of MUC5AC. Transfers GalNAc to three consecutive serine/threonine residues on SDC3 forming a triplet-Tn epitope expressed in Purkinje cells of the developing brain (By similarity). May promote neurogenesis through glycosylation and stabilization of PDPN (By similarity).
messages: Golgi apparatus membrane
messages: Membrane
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

10116:Hspa1b
gene id: 10116:Hspa1b
uniprot id: P0DMW1
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the heat shock protein 70 family.
messages: By heat shock.
messages: Cytoplasm
messages: HSPA1B is testis-specific.
messages: In response to cellular stress, acetylated at Lys-77 by NA110 and then gradually deacetylated by HDAC4 at later stages. Acetylation enhances its chaperone activity and also determines whether it will function as a chaperone for protein refolding or degradation by controlling its binding to co-chaperones HOPX and STUB1. The acetylated form and the non-acetylated form bind to HOPX and STUB1 respectively. Acetylation also protects cells against various types of cellular stress.
messages: May be an auxiliary component of the CatSper complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2. Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts with METTL21A. Interacts with TRIM5 (via B30.2/SPRY domain). Interacts with PRKN. Interacts with FOXP3. Interacts with NOD2; the interaction enhances NOD2 stability. Interacts with DNAJC9 (via J domain). Interacts with ATF5; the interaction protects ATF5 from degradation via proteasome-dependent and caspase-dependent processes. Interacts with NAA10, HSP40, HSP90 and HDAC4. The acetylated form and the non-acetylated form interact with HOPX and STUB1 respectively. Interacts with NEDD1 and SMAD3. Interacts (via NBD) with BAG1, BAG2, BAG3 and HSPH1/HSP105. Interacts with DNAJC8.
messages: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein re…
messages: The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
messages: centrosome

10116:LOC100913013
gene id: 10116:LOC100913013
uniprot id: A0A8I6GGC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a ligand for KLRK1.
messages: Belongs to the NKG2D ligand family.
messages: Cell membrane
messages: Membrane

10116:Sybu
gene id: 10116:Sybu
uniprot id: A6HRC1
names: Subcellular Location Annotation
messages: Membrane

10116:Or9g19
gene id: 10116:Or9g19
uniprot id: A0A0G2K7R4
uniprot id: A6HMU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ctnna2
gene id: 10116:Ctnna2
uniprot id: A6IAF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

10116:Dda1
gene id: 10116:Dda1
uniprot id: A6K9U2
names: Similarity
messages: Belongs to the DDA1 family.

10116:Clk4
gene id: 10116:Clk4
uniprot id: A6HE49
uniprot id: F7ETQ4
names: Similarity
messages: Belongs to the protein kinase superfamily.

10116:Ppp2cb
gene id: 10116:Ppp2cb
uniprot id: P62716
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
messages: Cytoplasm
messages: May be monoubiquitinated by NOSIP.
messages: Nucleus
messages: PP2A consists of a common heterodimeric core enzyme (composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65) (subunit A)) that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Binds PPME1. May indirectly interact with SGO1, most probably through regulatory B56 subunits. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with TBCD. Interacts with CTTNBP2NL. Interacts with PTPA.
messages: Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation (By similarity).
messages: Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (Lcmt1) and protein phosphatase methylesterase 1 (Ppme1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization (By similarity).
messages: centromere
messages: spindle pole

10116:Rnh1
gene id: 10116:Rnh1
uniprot id: A6HXQ3
uniprot id: E2RUH2
uniprot id: F7F8M8
uniprot id: P29315
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Brain, heart, lung, liver, spleen, testes and kidney; highest in the lung and lowest in the heart.
messages: Cytoplasm
messages: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
messages: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.
messages: The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNases via a large protein interaction surface on its interior side.

10116:Ino80e
gene id: 10116:Ino80e
uniprot id: Q6AYH2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.
messages: Nucleus
messages: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

10116:Aff2
gene id: 10116:Aff2
uniprot id: A0A0G2K1Y9
names: Similarity
messages: Belongs to the AF4 family.

10116:Myo19
gene id: 10116:Myo19
uniprot id: D3Z8I9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

10116:Pbx2
gene id: 10116:Pbx2
uniprot id: Q6MG87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

10116:Saa4
gene id: 10116:Saa4
uniprot id: Q5M878
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.
messages: Secreted

10116:Ufm1
gene id: 10116:Ufm1
uniprot id: Q5BJP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UFM1 family.
messages: Cytoplasm
messages: Interacts with UBA5. Interacts with UFC1.
messages: Nucleus
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription.

10116:Gata4
gene id: 10116:Gata4
uniprot id: A6K6F9
uniprot id: P46152
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed predominantly in gastric mucosa and at much lower levels in the intestine. Also expressed in testis.
messages: Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts (via the second Zn finger) with NFATC4 (By similarity). Interacts with LMCD1 (By similarity). Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes. Interacts with NR5A1, ZFPM2 and TBX5. Interacts with ZNF260. Interacts with TBX18.
messages: Methylation at Lys-299 attenuates transcriptional activity.
messages: Nucleus
messages: Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (By similarity). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (PubMed:15329343). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (By similarity).

10116:Tor1a
gene id: 10116:Tor1a
uniprot id: Q68G38
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum lumen
messages: Expressed in brain (at protein level).
messages: Homohexamer. Interacts with TOR1B; the interaction may be specific of neural tissues. Interacts (ATP-bound) with TOR1AIP1 and TOR1AIP2; the interactions induce ATPase activity. Interacts with KLHL14; preferentially when ATP-free. Interacts with KLC1 (via TPR repeats); the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with COPS4; the interaction associates TOR1A with the CSN complex. Interacts with SNAPIN; the interaction is direct and associates SNAPIN with the CSN complex. Interacts with STON2. Interacts (ATP-bound) with SYNE3 (via KASH domain); the interaction is required for SYNE3 nuclear envelope localization. Interacts with VIM; the interaction associates TOR1A with the cytoskeleton. Interacts with PLEC. Interacts (ATP-bound) with SLC6A3; regulates SLC6A3 transport to the plasma membrane.
messages: N-glycosylated.
messages: Nucleus inner membrane
messages: Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues (By similarity).
messages: growth cone
messages: secretory vesicle
messages: synaptic vesicle

10116:LOC686087
gene id: 10116:LOC686087
uniprot id: A0A8I5Y568
uniprot id: A6KUJ2
uniprot id: Q5RJS6
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation.

10116:Cd28
gene id: 10116:Cd28
uniprot id: G3V7C2
uniprot id: P31042
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70. Interacts with GRB2 (By similarity).
messages: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation.
messages: Membrane

10116:Ndrg2
gene id: 10116:Ndrg2
uniprot id: A0A0G2JSV0
uniprot id: A6KEE4
uniprot id: A6KEE6
uniprot id: Q8VBU2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the NDRG family.
messages: Broadly expressed, with highest levels in heart, liver, skeletal muscle and aorta.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor (By similarity). May be involved in dendritic cell and neuron differentiation.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm
messages: Up-regulated by aldosterone in kidney and colon, but not in heart. Down-regulated in cortex by antidepressant treatments.
messages: growth cone
messages: perinuclear region

10116:Gtf2a1l
gene id: 10116:Gtf2a1l
uniprot id: F7F7R8
uniprot id: Q641W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

10116:Pcdhga2
gene id: 10116:Pcdhga2
uniprot id: A0A9K3Y704
uniprot id: I6LBX0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

10116:Sema4c
gene id: 10116:Sema4c
uniprot id: A6INE2
uniprot id: D4A9J3
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Usp16
gene id: 10116:Usp16
uniprot id: Q2KJ09
names: Domain
names: Function
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Homotetramer. Associates with late pre-40S ribosomes.
messages: Nucleus
messages: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

10116:Zfyve26
gene id: 10116:Zfyve26
uniprot id: D4A8G9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZFYVE26 family.
messages: Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A (By similarity).
messages: Midbody
messages: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity).
messages: The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the midbody during cytokinesis.
messages: centrosome

10116:Or2v1
gene id: 10116:Or2v1
uniprot id: A6HDV1
uniprot id: D3ZNH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Fgf8
gene id: 10116:Fgf8
uniprot id: A0A8I5ZL19
uniprot id: A0A8I6B5D5
uniprot id: Q76LI5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

10116:Fam217a
gene id: 10116:Fam217a
uniprot id: Q5XHY8
names: Similarity
messages: Belongs to the FAM217 family.

10116:Pigo
gene id: 10116:Pigo
uniprot id: A0A8I5ZR91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:Rhox10
gene id: 10116:Rhox10
uniprot id: Q4TU73
names: Subcellular Location Annotation
messages: Nucleus

10116:Arid5b
gene id: 10116:Arid5b
uniprot id: A6JKU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARID5B family.
messages: Nucleus

10116:Olr1264
gene id: 10116:Olr1264
uniprot id: A6KUF8
uniprot id: D4A012
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Gnai2
gene id: 10116:Gnai2
uniprot id: A6I2Z9
uniprot id: P04897
uniprot id: Q45QN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. In this context, interacts with GNB2 (By similarity). Interacts with UNC5B (By similarity). Interacts with GPSM1 (PubMed:11121039). Interacts with RGS12 and RGS14 (PubMed:11387333). Interacts (inactive GDP-bound form) with NUCB1 (via GBA motif); the interaction leads to activation of GNAI3 (PubMed:21653697). Interacts (inactive GDP-bound form) with CCDC88C/DAPLE (via GBA motif) (By similarity). Interacts (inactive GDP-bound form) with CCDC8A/GIV (via GBA motif) (PubMed:19211784).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.
messages: Membrane
messages: centrosome

10116:Or4c12
gene id: 10116:Or4c12
uniprot id: A0A8I5ZPS1
uniprot id: A6HN50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Thra
gene id: 10116:Thra
uniprot id: A6HIU2
uniprot id: A6HIU4
uniprot id: P63059
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D. Interacts with AKAP13. Interacts with TP53INP2. Interacts with PER2 (By similarity). Isoform alpha-2 and isoform alpha-1 interact with TACC1, but the interaction with alpha-1 is weaker. The interaction with isoform alpha-1, but not alpha-2, is decreased in the presence of thyroid hormone T3 (By similarity).
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Does not bind thyroid hormone T3.
messages: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
messages: Nucleus

10116:Nphs2
gene id: 10116:Nphs2
uniprot id: Q8K4G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family.
messages: Interacts with nephrin/NPHS1, KIRRL1 and CD2AP (By similarity). Interacts with DDN.
messages: Membrane
messages: Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.

10116:Fat2
gene id: 10116:Fat2
uniprot id: O88277
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell junction
messages: Cell membrane
messages: Cerebellum-specific expression. Expressed in thin parallel fibers of cerebellar granule cells.
messages: Homodimer.
messages: In the developing cerebellum, expressed in granule cells in the inner external germinal layer and in migrating granule cells whereas proliferating cells in the outer extessornal germinal layer did not shown expression. Expression levels in the internal granule cell layer peak during the third postnatal week and remain considerably high in the adult cerebellum.
messages: Involved in the regulation of cell migration (PubMed:29053796). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (PubMed:12213440).
messages: trans-Golgi network

10116:Slco2b1
gene id: 10116:Slco2b1
uniprot id: A0A8I6AV99
uniprot id: A0A8L2QE88
uniprot id: A6I6J4
uniprot id: A6I6J7
uniprot id: Q9JHI3
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A conserved histidine residue in the third transmembrane domain (His-128) might play an essential role in the pH sensitivity of SLCO2B1/OATP2B1-mediated substrate transport. Transmembrane domain 1 (TM1) may be localized within the substrate binding pocket.
messages: Apical cell membrane
messages: Basal cell membrane
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Expressed in liver, kidney, heart, lung and retina. Widely distributed in all brain regions.
messages: In contrast with human ortholog, not able to transport steroid sulfate conjugates estrone 3-sulfate (E1S), dehydroepiandrosterone sulfate (DHEA-S) and pregnenolone sulfate (PregS).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins D2 (PGD2), E1 (PGE1) and E2 (PGE2), leukotriene C4, thromboxane B2 and L-thyroxine (PubMed:10973807). Also plays a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons. May act as a heme transporter that promotes cellular iron availability. Also transports heme by-product coproporphyrin III (CPIII), and may be involved in their hepatic disposition (By similarity). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. The exact transport mechanism has not been yet deciphered but most likely involves an anion exchange, coupling the cellular uptake of organic substrate with the efflux of an anionic compound. Hydrogencarbonate/HCO3(-) acts as a probable counteranion that exchanges for organic anions. Cytoplasmic glutamate may also act as counteranion in the placenta (By similarity).
messages: Membrane
messages: Most likely contributes to the absorption and the disposition of a wide range of drugs in the intestine and the liver.

10116:Iqub
gene id: 10116:Iqub
uniprot id: Q45GW3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein that anchors the radial spoke 1 (RS1) complex to the A microtubule of outer doublet microtubules in axonemes. The triple radial spokes (RS1, RS2 and RS3) are required to modulate beating of the sperm flagellum. May play a role in inhibiting signaling via MAPK1/ERK2 and MAPK3/ERK1. Additionally, may play a role in the functioning of cilia. Not required for the functioning of tracheal or ependymal cilia.
messages: Component of the axonemal radial spoke 1 (RS1) complex, at least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the anchor protein IQUB. Does not appear to be part of radial spoke complexes 2 or 3 (RS2 or RS3). Interacts with CALM1. Interacts with DNAJB13. Interacts with DYNLL2. Interacts with NME5 (By similarity). Interacts with RSPH3 (By similarity). Interacts with RSPH9 (By similarity). Interacts with ZMYND10. Interacts with calmodulin; the interaction occurs in conditions of low but not high calcium (By similarity).
messages: cilium
messages: flagellum axoneme

10116:Ccdc51
gene id: 10116:Ccdc51
uniprot id: Q5PPN7
names: Activity Regulation
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Channel activity inhibited by ATP via ABCB8/MITOSUR subunit.
messages: Mitochondrial potassium channel located in the mitochondrial inner membrane. Together with ABCB8/MITOSUR, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel). May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume.
messages: Mitochondrion inner membrane
messages: The mitochondrial potassium channel (mitoK(ATP)) forms a heteromultimer.

10116:Lnpk
gene id: 10116:Lnpk
uniprot id: A0JN29
uniprot id: A6HMC2
uniprot id: F7EZG8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

10116:Plpp4
gene id: 10116:Plpp4
uniprot id: F1LZ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

10116:Osmr
gene id: 10116:Osmr
uniprot id: Q65Z14
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Associates with IL31RA to form the IL31 receptor. Binds IL31 and activates STAT1, STAT3 and STAT5. Capable of transducing OSM-specific signaling events (By similarity). The OSM/OSM-R system is pivotal in the differentiation of oval cells into hepatocytes, thereby promoting liver regeneration.
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor (By similarity).
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: Widely expressed. Expressed at high levels in the liver, skin and spleen. In the liver it is expressed exclusively in the oval cells.

10116:Ubxn11
gene id: 10116:Ubxn11
uniprot id: Q8R512
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Interacts with GNA12, GNA13, RND1, RND2 and RND3.
messages: May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13.
messages: Strongly expressed in testis. Also expressed in lung, brain and thymus.
messages: cytoskeleton

10116:Fgfr4
gene id: 10116:Fgfr4
uniprot id: A0A8L2QQB7
uniprot id: Q498D6
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Endosome
messages: Membrane
messages: Monomer. Homodimer after ligand binding. Interacts with FGF1, FGF2, FGF4, FGF6, FGF8, FGF9, FGF16, FGF17, FGF18, FGF19, FGF21 and FGF23 (in vitro). Binding affinity for FGF family members is enhanced by interactions between FGFs and heparan sulfate proteoglycans. Interacts with KLB; this strongly increases the affinity for FGF19 and FGF23. Affinity for FGF19 is strongly increased by KLB and sulfated glycosaminoglycans. KLB and KL both interact with the core-glycosylated FGFR4 in the endoplasmic reticulum and promote its degradation, so that only FGFR4 with fully mature N-glycans is expressed at the cell surface. Identified in a complex with NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with MMP14 and HIP1. Interacts with STAT3 (By similarity).
messages: N-glycosylated. Full maturation of the glycan chains in the Golgi is essential for high affinity interaction with FGF19 (By similarity).
messages: Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity).
messages: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4 (By similarity).
messages: Ubiquitinated. Subject to proteasomal degradation when not fully glycosylated (By similarity).

10116:Ddx24
gene id: 10116:Ddx24
uniprot id: F7ETB4
uniprot id: Q6VEU8
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

10116:Ms4a15
gene id: 10116:Ms4a15
uniprot id: D3ZSU4
names: Similarity
messages: Belongs to the MS4A family.

10116:Slc35d1
gene id: 10116:Slc35d1
uniprot id: A6JRS5
names: Subcellular Location Annotation
messages: Membrane

10116:Zfp202
gene id: 10116:Zfp202
uniprot id: A6J3P9
uniprot id: D4A7G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

10116:Tmcc2
gene id: 10116:Tmcc2
uniprot id: A0A8I5ZVA9
uniprot id: A0A8I6A0X9
uniprot id: A6IC49
uniprot id: D3ZE26
names: Similarity
messages: Belongs to the TEX28 family.

10116:Slc47a2
gene id: 10116:Slc47a2
uniprot id: D4A4W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

10116:Lman1
gene id: 10116:Lman1
uniprot id: Q62902
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Exists both as a covalent disulfide-linked homohexamer, and a complex of three disulfide-linked dimers non-covalently kept together. Interacts with MCFD2. May interact with TMEM115. Interacts with RAB3GAP1 and RAB3GAP2. Interacts with UBXN6. Interacts with SERPINA1/alpha1-antitrypsin (By similarity).
messages: Golgi apparatus membrane
messages: Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins (By similarity).
messages: The FF ER export motif at the C-terminus is not sufficient to support endoplasmic reticulum exit, and needs assistance of Gln-508 for proper recognition of COPII coat components.

10116:Smim15
gene id: 10116:Smim15
uniprot id: A6I5J6
uniprot id: D4A573
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

10116:Frmd8
gene id: 10116:Frmd8
uniprot id: Q5U2R3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with iRhom1/RHBDF1 and iRhom2/RHBDF2 (via cytoplasmic N-termini); this interaction leads to mutual protein stabilization. Interacts with ADAM17; this interaction is indirect and mediated by iRhom proteins (By similarity). Interacts with LRP6; this interaction affects LRP6-binding to AXIN1 (By similarity).
messages: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity).
messages: cytosol

10116:Adgrg1
gene id: 10116:Adgrg1
uniprot id: A0A0G2JSP0
uniprot id: F1LMW3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Secreted

10116:Bscl2
gene id: 10116:Bscl2
uniprot id: Q5FVJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the seipin family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Plays a crucial role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (By similarity). In association with LDAF1, defines the sites of LD formation in the ER (By similarity). Also required for growth and maturation of small nascent LDs into larger mature LDs (By similarity). Mediates the formation and/or stabilization of endoplasmic reticulum-lipid droplets (ER-LD) contacts, facilitating protein and lipid delivery from the ER into growing LDs (By similarity). Regulates the maturation of ZFYVE1-positive nascent LDs and the function of the RAB18-ZFYVE1 complex in mediating the formation of ER-LD contacts (By similarity). Binds anionic phospholipids including phosphatidic acid (By similarity). Plays an important role in the differentiation and development of adipocytes (By similarity).
messages: Undecamer (an oligomer having eleven subunits) (By similarity). Oligomerization is important for its function in lipid droplet formation (By similarity). Interacts with LDAF1 to form an oligomeric complex (By similarity). Interacts with RAB18 (By similarity). Interacts with ZFYVE1 in a RAB18-dependent manner (By similarity).

10116:Pln
gene id: 10116:Pln
uniprot id: A6K492
uniprot id: P61016
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Heart.
messages: Homopentamer.
messages: Homopentamer. Interacts with HAX1. Interact with ATP2A2; the inhibition decreases ATP2A2 Ca(2+) affinity. Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2. Interacts with S100A1 in a Ca(2+)-dependent manner.
messages: In elongated spermatids, proteolytically cleaved by SPPL2C which modulates intracellular Ca(2+) homeostasis.
messages: Membrane
messages: Mitochondrion membrane
messages: Palmitoylated by ZDHHC16, promoting formation of the homopentamer.
messages: Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes (By similarity).
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Controls intracellular Ca(2+) levels in elongated spermatids. May play a role in germ cell differentiation.
messages: Sarcoplasmic reticulum membrane

10116:Nr2c1
gene id: 10116:Nr2c1
uniprot id: Q8VIJ4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Homodimer (By similarity). Heterodimer; with NR2C2 which is required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats (By similarity). Interacts with ESR1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. Interacts with NRIP1 (via its LXXLL motifs); the interaction provides corepressor activity. Interacts with HDAC3 (via the DNA-binding domain); the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation. Interacts with HDAC4 (via the DNA-binding domain). Interacts with PIAS1; the interaction is required for sumoylation of NR2C1. Interacts with UBE2I; the interaction is required for sumoylation of NR2C1. Interacts with KAT2B; the interaction acts as a corepressor of gene expression (By similarity).
messages: Nucleus
messages: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Also activator of OCT4 gene expression. Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation (By similarity).
messages: PML body
messages: Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-210, stimulated by all-trans retinoic acid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association with effector molecules, KAT2B and NRIP1. Phosphorylation on Ser-568 by PKC is important for protein stability and function as activator of RARB (By similarity).
messages: Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies. Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation by all-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequent sumoylation, suppresses OCT4 expression (By similarity).

10116:Art2b
gene id: 10116:Art2b
uniprot id: A6I6V2
uniprot id: P20974
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.
messages: Cell membrane
messages: Has both NAD(+) glycohydrolase and ADP-ribosyltransferase activity (to a lesser extent).
messages: Postthymic T-cells.

10116:Cox5b
gene id: 10116:Cox5b
uniprot id: P12075
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5B family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

10116:Asl
gene id: 10116:Asl
uniprot id: A0A8I6ARJ8
uniprot id: A6J0N5
uniprot id: P20673
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Acetylation modifies enzyme activity in response to alterations of extracellular nutrient availability. Acetylation increased with trichostin A (TSA) or with nicotinamide (NAM). Glucose increases acetylation by about a factor of 3 with decreasing enzyme activity. Acetylation on Lys-288 is decreased on the addition of extra amino acids resulting in activation of enzyme activity.
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues (By similarity). Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway (By similarity).
messages: Enzyme activity is regulated by acetylation.
messages: Homotetramer (By similarity). Forms tissue-specific complexes with ASS1, SLC7A1, HSP90AA1 and nitric oxide synthase NOS1, NOS2 or NOS3; the complex maintenance is independent of ASL catalytic function (By similarity).

10116:Psmb7
gene id: 10116:Psmb7
uniprot id: Q9JHW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

10116:Ctrc
gene id: 10116:Ctrc
uniprot id: P55091
names: Caution
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the peptidase S1 family. Elastase subfamily.
messages: Pancreas.
messages: Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors (By similarity). Has chymotrypsin-type protease activity and hypocalcemic activity (By similarity). Cleaves TRY4 and TRY5 and thereby inhibits their autoactivation (By similarity).
messages: Was originally thought to be elastase IV.

10116:Pdcl3
gene id: 10116:Pdcl3
uniprot id: A6INK5
uniprot id: Q4KLJ8
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (By similarity). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (PubMed:27496612). Modulates the activation of caspases during apoptosis (By similarity).
messages: Belongs to the phosducin family.
messages: By heat shock.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain) (By similarity). Forms ternary complexes with the chaperonin CCT complex and actin substrate, leading to inhibition of actin folding (By similarity). Interacts with XIAP (via BIR 3 and RING domain) (By similarity). Interacts with HSP90AA1 and HSP90AB1 (PubMed:27496612).
messages: N-terminal methionine acetylation destabilizes the protein.
messages: perinuclear region

10116:Resp18
gene id: 10116:Resp18
uniprot id: P47940
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the RESP18 family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: May play an important regulatory role in corticotrophs.
messages: Pituitary, hypothalamus and pancreas (PubMed:8132649). Found in alpha, beta and delta cells in the pancreatic islets (PubMed:17951542).
messages: secretory vesicle lumen

10116:Pmpca
gene id: 10116:Pmpca
uniprot id: A6JTE5
uniprot id: F7F3I1
names: Similarity
messages: Belongs to the peptidase M16 family.

10116:Prxl2a
gene id: 10116:Prxl2a
uniprot id: Q6AXX6
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm
messages: Expressed by the principal cells of the epididymis. Detected in the head region of epididymal sperm (at protein level). Expressed in bone marrow.
messages: Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway.
messages: Secreted
messages: The active site cysteines correspond to the redox-active cysteines of peroxiredoxins.
messages: Up-regulated on CSF1 treatment.

10116:Fcgrt
gene id: 10116:Fcgrt
uniprot id: A6JAW9
uniprot id: P13599
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:18818657, PubMed:7969498). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (PubMed:7298722, PubMed:18818657). Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (By similarity).
messages: Endosome membrane
messages: FcRn complex consists of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer (PubMed:2911353, PubMed:7969498, PubMed:9493268). Interacts with albumin/ALB; this interaction regulates ALB homeostasis (By similarity).
messages: Intestinal epithelium.
messages: Membrane

10116:Cyp2f4
gene id: 10116:Cyp2f4
uniprot id: O35293
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl-1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or club cells in lung.
messages: Microsome membrane

10116:Rad9a
gene id: 10116:Rad9a
uniprot id: A6HYV6
uniprot id: D3ZXM2
names: Similarity
messages: Belongs to the rad9 family.

10116:Hs6st3
gene id: 10116:Hs6st3
uniprot id: A0A8I5ZN51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

10116:Gnl2
gene id: 10116:Gnl2
uniprot id: Q4KLJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

10116:Fam98a
gene id: 10116:Fam98a
uniprot id: Q5FWT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FAM98 family.
messages: Interacts (via N- and C-terminus) with DDX1. Interacts (via N- and C-terminus) with C14orf166. Interacts with FAM98B. Interacts with PLEKHM1 (via N- and C-terminus).
messages: Positively stimulates PRMT1-induced protein arginine methylation. Involved in skeletal homeostasis. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts.

10116:Tle2
gene id: 10116:Tle2
uniprot id: A6K867
uniprot id: Q496Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

10116:Or2aa1
gene id: 10116:Or2aa1
uniprot id: D4A522
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:LOC500331
gene id: 10116:LOC500331
uniprot id: Q5M9I1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lectin-type cell surface receptor.

10116:Or12e1
gene id: 10116:Or12e1
uniprot id: A6HMY8
uniprot id: M0RBX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Crygd
gene id: 10116:Crygd
uniprot id: A6IPJ1
uniprot id: P10067
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Detected in the superior olivary complex and fibers of the ventral aoustic stria of the auditory hindbrain.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: There are six different gamma crystallins identified in rat lens.

10116:Trim40
gene id: 10116:Trim40
uniprot id: Q6MFY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response. Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation. Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation.
messages: Interacts with NEDD8.

10116:Mogat3
gene id: 10116:Mogat3
uniprot id: F1LT39
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Casp8
gene id: 10116:Casp8
uniprot id: Q9JHX4
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: CASP8 activity is restricted by RIPK1.
messages: Cytoplasm
messages: Generation of the subunits requires association with the death-inducing signaling complex (DISC), whereas additional processing is likely due to the autocatalytic activity of the activated protease. GZMB and CASP10 can be involved in these processing events (By similarity).
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 10 kDa (p10) subunit (By similarity). Interacts with FADD, CFLAR and PEA15 (By similarity). Interacts with RFFL and RNF34; negatively regulate CASP8 through proteasomal degradation (By similarity). Interacts with TNFAIP8L2 (By similarity). Interacts with CASP8AP2 (By similarity). Interacts with NOL3; decreases CASP8 activity in a mitochondria localization- and phosphorylation-dependent manner and this interaction is dissociated by calcium (PubMed:15383280). Interacts with UBR2 (By similarity). Interacts with RIPK1 (By similarity). Interacts with stimulated TNFRSF10B; this interaction is followed by CASP8 proteolytic cleavage and activation (By similarity). Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis) (By similarity).
messages: Nucleus
messages: Phosphorylation on Ser-389 during mitosis by CDK1 inhibits activation by proteolysis and prevents apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (By similarity).
messages: Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (By similarity). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death (PubMed:10197541). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (By similarity). Binding to the adapter molecule FADD recruits it to either receptor TNFRSF6/FAS mediated or TNFRSF1A (PubMed:10197541). The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (By similarity). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (By similarity). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (By similarity). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-325', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (By similarity). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-C and -D (GSDMC and GSDMD, respectively): gasdermin cleavage promotes release of the N-terminal moiety that binds to membranes and forms pores, triggering pyroptosis (By similarity). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways (By similarity). Cleaves PARP1 and PARP2 (By similarity).

10116:Cyp1a1
gene id: 10116:Cyp1a1
uniprot id: A6J4X3
uniprot id: P00185
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15alpha and C16alpha positions (By similarity). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (By similarity). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system. Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (By similarity). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (By similarity). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (By similarity).
messages: Belongs to the cytochrome P450 family.
messages: Both Cytochrome P450MT2A and Cytochrome P450MT2B interact with cytosolic chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria. P450MT2B interacts (via mitochondrial targeting signal) with TOMM40 (via N-terminus); this interaction is required for translocation across the mitochondrial outer membrane.
messages: By 3-methylcholanthrene (3MC) and beta-naphthoflavone (BNF).
messages: Contains a chimeric signal that facilitates targeting of the protein to both the endoplasmic reticulum and mitochondria. A 12 amino acid sequence between 33 and 44 functions as a putative mitochondrial-targeting signal. The removal of the first 4- or 32-amino acid residues from the intact protein positions the mitochondrial targeting signal for efficient binding to the mitochondrial import receptors. The membrane-free P4501A1 seems to be more sensitive to proteolysis.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Liver.
messages: Membrane
messages: Microsome membrane
messages: Mitochondrion inner membrane
messages: Two forms; MT2A (long form) and MT2B (short form); are produced by NH2-terminal proteolytic cleavage. This cleavage activates a cryptic mitochondrial targeting signal.

10116:L1cam
gene id: 10116:L1cam
uniprot id: A0A8I6AMQ8
uniprot id: D3ZPC4
uniprot id: Q05695
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Cell membrane
messages: Interacts with SHTN1; the interaction occurs in axonal growth cones (PubMed:18519736). Interacts with isoform 2 of BSG (By similarity).
messages: Isoform 2 is predominantly found in the brain, while isoform 1 is found in the peripheral nervous system.
messages: Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
messages: growth cone

10116:Kpna4
gene id: 10116:Kpna4
uniprot id: Q56R17
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

10116:Pnliprp1
gene id: 10116:Pnliprp1
uniprot id: P54316
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity (in vitro) (By similarity).
messages: Secreted
messages: Was originally thought to be the pancreatic lipase.

10116:Miga2
gene id: 10116:Miga2
uniprot id: A0A0G2KAE6
uniprot id: A6JTY1
uniprot id: A6JTY2
uniprot id: D3Z899
names: Similarity
messages: Belongs to the mitoguardin family.

10116:Txndc8
gene id: 10116:Txndc8
uniprot id: Q69AB1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the thioredoxin family.
messages: Cytoplasm
messages: Golgi apparatus
messages: In vasectomized rats, autoantibodies against Txndc8 are present.
messages: May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm (By similarity).
messages: Testis-specific. Expressed in spermatozoa, sperm tail, elongated and round spermatids.

10116:Mrps14
gene id: 10116:Mrps14
uniprot id: A0A8I6AAC9
uniprot id: A0A8I6AMX3
uniprot id: B2RYT4
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

10116:Ttc39a
gene id: 10116:Ttc39a
uniprot id: B5DEK2
names: Similarity
messages: Belongs to the TTC39 family.

10116:Cyth2
gene id: 10116:Cyth2
uniprot id: P63035
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth (By similarity).
messages: Autoinhibited by its C-terminal basic region.
messages: Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate. The PH domain is necessary and sufficient for plasma membrane relocalization (By similarity).
messages: Cell membrane
messages: Cell projection
messages: Cytoplasm
messages: Heteromer. Composed of TAMALIN, CYTH2 and at least one GRM1. Interacts with ARRB1. Interacts with ARL4D; the interaction is direct (By similarity). Directly interacts with CCDC120 through the coiled coil domain; this interaction stabilizes CCDC120, possibly by preventing its ubiquitination, and is required for neurite growth in a neuroblastoma cell line. Interacts with FRMD4A (By similarity). Interacts (via N-terminal domain) with INAVA (via N-terminal domain) (By similarity).
messages: On embryonic days 15 (15 dpc) and 18 dpc, a weak expression is seen in the mantle and ventricular germinal zones throughout the neuraxis. On postnatal days 0 (P0) and P7, weakly expressed in the gray matter, but not in the white matter, throughout the brain. In the cerebellum, the expression is seen in the external granule cell layer.
messages: Present in all tissues tested, with highest protein levels in brain and adrenal.
messages: The coiled coil domain is involved in interaction with CCDC120.
messages: adherens junction
messages: growth cone
messages: tight junction

10116:Nxph1
gene id: 10116:Nxph1
uniprot id: A6IDY4
uniprot id: Q63366
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the neurexophilin family.
messages: Highest level in brain.
messages: May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.
messages: May be signaling molecules that resemble neuropeptides.
messages: May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).
messages: Secreted

10116:Slc6a2
gene id: 10116:Slc6a2
uniprot id: Q9WTR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

10116:Ppp1r10
gene id: 10116:Ppp1r10
uniprot id: A4QN30
uniprot id: O55000
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1CC. Interacts with PPP1CA, WDR82 and TOX4 (By similarity).
messages: Expressed in testis, brain and intestine (at protein level). Highly expressed in testis.
messages: Nucleus
messages: Phosphorylated on Thr-398 by PKA within the region necessary for interaction with PPP1CA.
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.

10116:Dnase2
gene id: 10116:Dnase2
uniprot id: A6IY62
uniprot id: Q9QZK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DNase II family.
messages: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells.
messages: Lysosome
messages: Ubiquitous.

10116:Rnf4
gene id: 10116:Rnf4
uniprot id: O88846
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autoubiquitinated.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation (PubMed:14987998, PubMed:18408734, PubMed:15707587). Regulates the degradation of several proteins including PML and the transcriptional activator PEA3 (PubMed:15707587, PubMed:20943951). Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation (By similarity). Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 (By similarity). Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation (PubMed:11319220, PubMed:9710597). Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97 (By similarity).
messages: Homodimer (via RING-type zinc finger domain) (PubMed:20681948). Interacts with GSC2 (By similarity). Interacts with AR/the androgen receptor and TBP (PubMed:9710597). Interacts with TCF20 (By similarity). Interacts with PATZ1. Interacts with TRPS1; negatively regulates TRPS1 transcriptional repressor activity. Interacts with PML (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4, isoform PML-5 and isoform PML-6) (PubMed:15707587, PubMed:20943951). Interacts with PRDM1/Blimp-1 (By similarity).
messages: Nucleus
messages: PML body
messages: Sumoylated; conjugated by one or two SUMO1 moieties.
messages: The RING-type zinc finger domain is required for the ubiquitination of polysumoylated substrates.
messages: The SUMO interaction motifs (SIMs) mediates the binding to polysumoylated substrate.
messages: Widely expressed with highest levels in testis.
messages: nucleoplasm

10116:Defb50
gene id: 10116:Defb50
uniprot id: Q30KJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has bactericidal activity.
messages: Secreted

10116:Os9
gene id: 10116:Os9
uniprot id: A0A8I6GKC0
uniprot id: Q5RKH6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum lumen
messages: Interacts (via C-terminus) with CPNE6 (via second C2 domain); this interaction occurs in a calcium-dependent manner in vitro (By similarity). Component of the HRD1 complex, which comprises at least SYNV1/HRD1, DERL1/2, FAM8A1, HERPUD1/HERP, OS9, SEL1L and UBE2J1. FAM8A1 is stabilized by interaction with SYNV1, which prevents its proteasomal degradation. OS9 and UBE2J1 recruitment to the complex may be mediated by SEL1L (By similarity). Through this complex, may interact with ERLEC1 and HSPA5 (By similarity). Interacts with HSP90B1 (By similarity). Interacts with CREB3 (By similarity).
messages: Intramolecular disulfide bonds.
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.
messages: Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 (By similarity).
messages: N-glycosylated.

10116:Sgsm1
gene id: 10116:Sgsm1
uniprot id: D3ZAS2
names: Similarity
messages: Belongs to the RUTBC family.

10116:Olr1720
gene id: 10116:Olr1720
uniprot id: A0A8I6A537
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Bcap31
gene id: 10116:Bcap31
uniprot id: A0A8I5ZTY8
uniprot id: Q6AY58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

10116:Mpped1
gene id: 10116:Mpped1
uniprot id: A6HTA6
uniprot id: D4A120
names: Similarity
messages: Belongs to the UPF0046 family.

10116:Or52n2b
gene id: 10116:Or52n2b
uniprot id: A6I7G5
uniprot id: D4A2S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tomm70
gene id: 10116:Tomm70
uniprot id: Q75Q39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:11956321, PubMed:19401463). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (By similarity).
messages: Belongs to the Tom70 family.
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70) (By similarity). Interacts with CAPN8 (By similarity). Interacts with TRADD, TRAF6 and STING. Interacts with MAVS. Interacts with HSPA8 and HSP90AA1; both interactions are required for preprotein mitochondrial import. The interaction with HSP90AA1 is direct and mediates the association of TOMM70 with IRF3 and TBK1 (By similarity).
messages: Mitochondrion outer membrane

10116:Or4k44
gene id: 10116:Or4k44
uniprot id: A6HP30
uniprot id: D3ZHY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Olr1329
gene id: 10116:Olr1329
uniprot id: A0A0G2K2E7
uniprot id: A6J3N5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Mrpl33
gene id: 10116:Mrpl33
uniprot id: A6HA41
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

10116:Whrn
gene id: 10116:Whrn
uniprot id: Q810W9
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Forms homooligomers (By similarity). Interacts (via C-terminal PDZ domain) with MYO15A; this interaction is necessary for localization of WHRN to stereocilia tips. Interacts (via C-terminal PDZ domain) with MPP1/p55. Interacts with LRRC4C/NGL1. Interacts with MYO7A. Interacts with RPGR. Interacts with EPS8 (By similarity). Interacts with CASK (PubMed:12641734). Interacts with CIB2 (By similarity). Component of USH2 complex, composed of ADGRV1, PDZD7, USH2A and WHRN. Interacts (via PDZ domains) with PDZD7; the interaction is direct. Interacts (via N-terminal PDZ domain) with USH2A (via cytoplasmic region). Interacts with ADGRV1/MASS1 (via cytoplasmic region) (By similarity).
messages: Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.
messages: Synapse
messages: Ubiquitous. Highly expressed in heart, spleen, lung and liver. Highly expressed in brain, in the olfactory bulb, thalamus, layers III-V of the cerebral cortex and the molecular layer of cerebellum. Detected in soma and dendrites of thalamic neurons, and in cerebrum in cell bodies and apical dendrites of pyramidal neurons. Expressed in retina and inner ear (PubMed:16434480, PubMed:23055499).
messages: growth cone
messages: stereocilium

10116:Pold1
gene id: 10116:Pold1
uniprot id: A6JAQ6
uniprot id: G3V8M1
uniprot id: O54747
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine, 8oxoG or abasic sites.
messages: Belongs to the DNA polymerase type-B family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Component of the tetrameric DNA polymerase delta complex (Pol-delta4), which consists of POLD1/p125, POLD2/p50, POLD3/p66/p68 and POLD4/p12, with POLD1 bearing both DNA polymerase and 3' to 5' proofreading exonuclease activities. Within Pol-delta4, directly interacts with POLD2 and POLD4. Following genotoxic stress by DNA-damaging agents, such as ultraviolet light and methyl methanesulfonate, or by replication stress induced by treatment with hydroxyurea or aphidicolin, Pol-delta4 is converted into a trimeric form of the complex (Pol-delta3) by POLD4 degradation. Pol-delta3 is the major form at S phase replication sites and DNA damage sites. POLD1 displays different catalytic properties depending upon the complex it is found in. It exhibits higher proofreading activity and fidelity than Pol-delta4, making it particularly well suited to respond to DNA damage. Directly interacts with PCNA, as do POLD3 and POLD4; this interaction stimulates Pol-delta4 polymerase activity. As POLD2 and POLD4, directly interacts with WRNIP1; this interaction stimulates DNA polymerase delta-mediated DNA synthesis, independently of the presence of PCNA. This stimulation may be due predominantly to an increase of initiation frequency and also to increased processivity. Also observed as a dimeric complex with POLD2 (Pol-delta2). Pol-delta2 is relatively insensitive to the PCNA stimulation (2-5-fold) compared to Pol-delta4 that is stimulated by over 50-fold. The DNA polymerase delta complex interacts with POLDIP2; this interaction is probably mediated through direct binding to POLD2. Interacts with CIAO1. Interacts with POLDIP2 (By similarity).
messages: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
messages: Nucleus
messages: Regulated by alteration of quaternary structure. Exhibits burst rates of DNA synthesis are about 5 times faster in the presence of POLD4 (Pol-delta4 complex) than in its absence (Pol-delta3 complex), while the affinity of the enzyme for its DNA and dNTP substrates appears unchanged. The Pol-delta3 complex is more likely to proofread DNA synthesis because it cleaves single-stranded DNA twice as fast and transfers mismatched DNA from the polymerase to the exonuclease sites 9 times faster compared to the Pol-delta3 complex. Pol-delta3 also extends mismatched primers 3 times more slowly in the absence of POLD4. The conversion of Pol-delta4 into Pol-delta3 is induced by genotoxic stress or by replication stress leading POLD4 degradation. Stimulated in the presence of PCNA (By similarity). This stimulation is further increased in the presence of KCTD13/PDIP1, most probably via direct interaction between KCTD13 and POLD2 (By similarity).
messages: The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.

10116:Or1o2e
gene id: 10116:Or1o2e
uniprot id: Q6MFW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Plp2
gene id: 10116:Plp2
uniprot id: A6KP90
uniprot id: Q6P742
names: Function
names: Subcellular Location Annotation
messages: May play a role in cell differentiation in the intestinal epithelium.
messages: Membrane

10116:Fabp3
gene id: 10116:Fabp3
uniprot id: A6ISN9
uniprot id: P07483
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
messages: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
messages: Heart, but also skeletal muscle, kidney, brain and mammary gland.

10116:Ptgfr
gene id: 10116:Ptgfr
uniprot id: A6HWJ3
uniprot id: P43118
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Highest expression in pregnant ovary. Also found in a low extent in the kidney. In the brain, expressed in astrocytes and oligodendrocytes, and meningeal fibroblasts, but not in migroglia cells.
messages: Membrane
messages: Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum.

10116:Man1c1
gene id: 10116:Man1c1
uniprot id: A6IT34
uniprot id: D3Z979
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

10116:Cfap300
gene id: 10116:Cfap300
uniprot id: Q68FQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CFAP300 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
messages: Cytoplasm
messages: Interacts with DNAAF2.
messages: cilium axoneme

10116:Cflar
gene id: 10116:Cflar
uniprot id: C0H5Y5
uniprot id: F7FBZ4
names: Similarity
messages: Belongs to the peptidase C14A family.

10116:Icam2
gene id: 10116:Icam2
uniprot id: F7F7V6
uniprot id: Q6AXM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

10116:Lamb3
gene id: 10116:Lamb3
uniprot id: A6JH29
uniprot id: F1LPI5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Or4a77e
gene id: 10116:Or4a77e
uniprot id: A0A8I6ALE0
uniprot id: A6HN45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Rabif
gene id: 10116:Rabif
uniprot id: Q08326
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the DSS4/MSS4 family.
messages: Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1, RAB3A and RAB10, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport.
messages: Interacts with RAB8A.
messages: Ubiquitous.

10116:Tmem216
gene id: 10116:Tmem216
uniprot id: B6ID01
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Due to intron retention.
messages: Membrane
messages: Part of the tectonic-like complex (also named B9 complex). Interacts with TMEM107.
messages: Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition.
messages: cilium basal body

10116:Uhmk1
gene id: 10116:Uhmk1
uniprot id: Q63285
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm
messages: In the embryo, preferentially expressed in the developing nervous system.
messages: Interacts with stathmin and CDKN1B/p27Kip1 (By similarity) Interacts with PAM.
messages: Nucleus
messages: Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).

10116:Mapt
gene id: 10116:Mapt
uniprot id: A0A8I5ZN17
uniprot id: A0A8J8XUY4
uniprot id: A0A8K1TMD4
uniprot id: A0A8K1TN53
uniprot id: A0A8K1WG57
uniprot id: A0A8K1WHA3
uniprot id: A0JN25
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: axon
messages: cytoskeleton
messages: cytosol
messages: dendrite

10116:Bglap
gene id: 10116:Bglap
uniprot id: A6J671
uniprot id: P04640
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation by GGCX. These residues are essential for the binding of calcium (By similarity). Decarboxylation promotes the hormone activity (By similarity).
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted
messages: The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein: it acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization. The carboxylated form binds strongly to apatite and calcium.
messages: The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development.

10116:Krtap24-1
gene id: 10116:Krtap24-1
uniprot id: M0R854
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

10116:Foxi1
gene id: 10116:Foxi1
uniprot id: A6HDI0
uniprot id: D4A7G2
names: Subcellular Location Annotation
messages: Nucleus

10116:Efs
gene id: 10116:Efs
uniprot id: B1WBZ1
uniprot id: F7F497
names: Similarity
messages: Belongs to the CAS family.

10116:Vom2r77
gene id: 10116:Vom2r77
uniprot id: M0R9L8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Nptn
gene id: 10116:Nptn
uniprot id: P97546
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Interacts with ATP2B1; this interaction stabilizes ATP2B1 and increases ATPase activity; this interaction controls T cell calcium homeostasis following T cell activation. Interacts with XKR8; promoting its localization at the cell membrane.
messages: Isoform 1 and isoform 2 are N-glycosylated.
messages: Isoform 1 is detectable at all developmental stages starting from postnatal day 1. Isoform 2 is low at postnatal day 1, increases steadily until postnatal days 20-25 and then declines to an intermediate level.
messages: Isoform 1 is ubiquitously expressed. Isoform 2 is brain-specific. In brain isoform 2 is highly expressed in hippocampus and cerebral cortex and weakly in cerebellum and lower brain regions. In the hippocampus isoform 2 is found in the dentate gyrus and CA1-CA4, the striatum oriens of CA3 shows the higher level.
messages: Postsynaptic density
messages: Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK (PubMed:10759566, PubMed:16925595). May also regulate neurite outgrowth by activating the FGFR1 signaling pathway (PubMed:10759566, PubMed:16925595). May play a role in synaptic plasticity (PubMed:10759566, PubMed:16925595). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity. Promotes localization of XKR8 at the cell membrane (By similarity).
messages: Some isoforms lack the first Ig-like domain which may confer homophilic adhesion activity. However, they can bind and activate FGFR1.

10116:Gpc6
gene id: 10116:Gpc6
uniprot id: A0A096MJY1
uniprot id: A0A8I6A609
uniprot id: A6HUF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

10116:Ccdc86
gene id: 10116:Ccdc86
uniprot id: A6I074
uniprot id: Q5XIB5
names: PTM
names: Subcellular Location Annotation
messages: Citrullinated by PADI4.
messages: Nucleus

10116:Gal3st3
gene id: 10116:Gal3st3
uniprot id: F7F952
uniprot id: Q505J7
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

10116:Prelp
gene id: 10116:Prelp
uniprot id: Q9EQP5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds the basement membrane heparan sulfate proteoglycan perlecan and triple helical collagens type I and type II.
messages: Glycosylated; contains heparan sulfate.
messages: May anchor basement membranes to the underlying connective tissue.
messages: The basic N-terminal Arg/Pro-rich region binds heparin and heparan sulfate. Binds collagens type I and type II through its leucine-rich repeat domain.
messages: extracellular matrix

10116:Scrib
gene id: 10116:Scrib
uniprot id: A0A8I6APB3
uniprot id: A6HS51
uniprot id: A6HS52
uniprot id: A6HS53
uniprot id: D3ZWS0
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

10116:Myo15a
gene id: 10116:Myo15a
uniprot id: A0A0G2K1F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: cytoskeleton

10116:Chid1
gene id: 10116:Chid1
uniprot id: A0JPQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Interacts with STAB1.
messages: Lysosome
messages: Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro) (By similarity).
messages: Secreted

10116:Rora
gene id: 10116:Rora
uniprot id: F1LZZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

10116:Gria1
gene id: 10116:Gria1
uniprot id: A6HEN8
uniprot id: P19490
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.
messages: Both variants Ser-710 and Thr-710 are phosphorylated at this position.
messages: Cell membrane
messages: Detected in cerebellum (at protein level).
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits (PubMed:21639859). Tetramers may be formed by the dimerization of dimers (By similarity). Found in a complex with GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (PubMed:16793768, PubMed:19265014). Interacts with HIP1 and RASGRF2. Interacts with SYNDIG1 and GRIA2 (By similarity). Interacts with DLG1 (via C-terminus) (PubMed:12070168, PubMed:17069616, PubMed:9677374). Interacts with LRFN1 (PubMed:16630835). Interacts with PRKG2 (PubMed:18031684). Interacts with CNIH2 and CACNG2 (PubMed:20805473). Interacts with CACNG5 (PubMed:18817736, PubMed:19234459). Interacts (via C-terminus) with PDLIM4 (via LIM domain); this interaction as well as the interaction of PDLIM4 with alpha-actinin is required for their colocalization in early endosomes (PubMed:15456832). Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes. Interacts (via PDZ-binding motif) with SHANK3 (via PDZ domain) (By similarity). Interacts with CACNG3; associates GRIA1 with the adapter protein complex 4 (AP-4) to target GRIA1 to the somatodendritic compartment of neurons (By similarity).
messages: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
messages: Membrane
messages: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
messages: Phosphorylated at Ser-645 (PubMed:7877986). Phosphorylated at Ser-710 by PKC (PubMed:8848293). Phosphorylated at Ser-849 by PKC, PKA and CAMK2 (PubMed:9405465). Phosphorylated at Ser-863 by PKC, PKA and PRKG2 (PubMed:18031684, PubMed:9405465). Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation (By similarity).
messages: Postsynaptic cell membrane
messages: Postsynaptic density membrane
messages: Presynapse
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Recycling endosome membrane
messages: Synapse
messages: The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.
messages: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.
messages: dendrite
messages: dendritic spine

10116:Nf2
gene id: 10116:Nf2
uniprot id: A0A8I6A8G0
uniprot id: A6IKH9
uniprot id: A6IKI1
uniprot id: G3V717
uniprot id: Q63648
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cell projection
messages: Interacts with NHERF1, HGS and AGAP2. Interacts with SGSM3. Interacts (via FERM domain) with MPP1. Interacts with LAYN and WWC1. Interacts with the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. The unphosphorylated form interacts (via FERM domain) with VPRBP/DCAF1. Interacts (via FERM domain) with NOP53; the interaction is direct. Interacts with SCHIP1; the interaction is direct.
messages: Membrane
messages: Nucleus
messages: Phosphorylation of Ser-514 inhibits nuclear localization by disrupting the intramolecular association of the FERM domain with the C-terminal tail. The dephosphorylation of Ser-514 favors the interaction with NOP53.
messages: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex Plays a role in lens development and is required for complete fiber cell terminal differentiation, maintenance of cell polarity and separation of the lens vesicle from the corneal epithelium.
messages: Ubiquitinated by the CUL4A-RBX1-DDB1-DCAF1/VprBP E3 ubiquitin-protein ligase complex for ubiquitination and subsequent proteasome-dependent degradation.
messages: cytoskeleton

10116:Tent5d
gene id: 10116:Tent5d
uniprot id: A6IV72
uniprot id: D4A3M4
names: Similarity
messages: Belongs to the TENT family.

10116:Rbms1
gene id: 10116:Rbms1
uniprot id: Q5PQP1
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication (By similarity).

10116:Slu7
gene id: 10116:Slu7
uniprot id: B0BNL0
uniprot id: Q80ZG5
names: Domain
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Component of pre-catalytic, catalytic and post-catalytic spliceosomes. Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing.
messages: Many sequencing errors.
messages: Nucleus
messages: Nucleus speckle
messages: Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.
messages: The CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle back to the cytoplasm via the CRM1 pathway.

10116:Lonp1
gene id: 10116:Lonp1
uniprot id: A6KQW3
uniprot id: Q924S5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK) and the large ribosomal subunit protein MRPL32/bL32m. MRPL32/bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters.
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters.
messages: Belongs to the peptidase S16 family.
messages: By hypoxia or ER stress.
messages: Homohexamer. Organized in a ring with a central cavity. The ATP-binding and proteolytic domains (AP-domain) form a hexameric chamber, while the N-terminal domain is arranged as a trimer of dimers. DNA and RNA binding is stimulated by substrate and inhibited by ATP binding. Interacts with TWNK and mitochondrial DNA polymerase subunit POLG.
messages: Mitochondrion matrix

10116:Rpl24
gene id: 10116:Rpl24
uniprot id: A6IQQ7
uniprot id: P83732
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Mono-ADP-ribosylation at Glu-4 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation.

10116:Cops8
gene id: 10116:Cops8
uniprot id: Q6P4Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN8 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).
messages: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9. In the complex, it probably interacts directly with COPS3, COPS4 and COPS7 (COPS7A or COPS7B).
messages: Cytoplasm
messages: Nucleus

10116:Rps2
gene id: 10116:Rps2
uniprot id: P27952
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region.
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Citrullinated by PADI4 in the Arg/Gly-rich region.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (By similarity). Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).
messages: Component of the small ribosomal subunit. Interacts with zinc finger protein ZNF277 (via zinc-finger domains); the interaction is direct; the interaction is extra-ribosomal. Interaction with ZNF277 competes with the binding of RPS2 to protein arginine methyltransferase PRMT3.
messages: Cytoplasm
messages: Monoubiquitinated at Lys-54 and Lys-58 by RNF10 when a ribosome has stalled during translation, leading to its degradation by the proteasome. Deubiquitinated at Lys-54 and Lys-58 by USP10, preventing degradation by the proteasome and promoting 40S ribosome subunit recycling following ribosome dissociation.
messages: nucleolus

10116:Neu4
gene id: 10116:Neu4
uniprot id: A6JR43
uniprot id: D3ZWB7
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

10116:Cpsf4
gene id: 10116:Cpsf4
uniprot id: Q5FVR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with FIP1L1 (By similarity).
messages: Nucleus

10116:Tead4
gene id: 10116:Tead4
uniprot id: A0A8I6AIX9
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.

10116:Sumf2
gene id: 10116:Sumf2
uniprot id: A6J0P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

10116:Or6b1
gene id: 10116:Or6b1
uniprot id: A6IF96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Bok
gene id: 10116:Bok
uniprot id: A6JR24
uniprot id: Q792S6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:9356461, PubMed:9804769). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (By similarity). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (By similarity). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner. Plays a role in granulosa cell apoptosis by CASP3 activation (By similarity). Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression. May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (By similarity).
messages: BH4 domain mediates interaction with ITPR1.
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Early endosome membrane
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Expressed in ovary, testis and uterus.
messages: Isoform 1: Honomer; positively regulates apoptotic process. Homodimer (By similarity). Heterodimer (PubMed:9804769). Oligomer; promoted by apoptotic stimuli and BH3-only proteins; mediates constitutive activation. Interacts (via BH4 domain) with ITPR1; enhances BOK expression and stabilization; limits apoptosis and prevents ubiquitination and then degradation; protects ITPR1 from proteolysis by CASP3 during apoptosis. Interacts with ITPR2 and ITPR3; binds most strongly to ITPR2, and barely to ITPR3; regulates their expression (By similarity). Interacts with XPO1; translocates to the cytoplasm. Interacts with BNIP3; promotes oligomerization (By similarity). Isoform 2: Does not heterodimerize with antiapoptotic Bcl-2 proteins (PubMed:9804769).
messages: Membrane
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Mitochondrion outer membrane
messages: Nucleus
messages: Nucleus outer membrane
messages: Positively regulates apoptotic process in an heterodimerization-independent manner with antiapoptotic Bcl-2 proteins.
messages: Recycling endosome membrane
messages: Ubiquitinated by AMFR/gp78 E3 ubiquitin ligase complex; mediates degradation by ubiquitin-proteasome pathway in a VCP/p97-dependent manner; prevents from proapoptotic activity; promotes degradation of newly synthesized proteins that are not ITPR1 associated.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

10116:Atp11c
gene id: 10116:Atp11c
uniprot id: A0A8I6AUH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

10116:Armc9
gene id: 10116:Armc9
uniprot id: A6JWG3
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with TOGARAM1, CCDC66, CEP104, CSPP1 and CEP290.
messages: centriole
messages: cilium
messages: cilium basal body

10116:Olr1271
gene id: 10116:Olr1271
uniprot id: F7FJ37
uniprot id: Q63395
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tnfrsf21
gene id: 10116:Tnfrsf21
uniprot id: D3ZF92
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Associates with TRADD. Interacts with NGFR. Interacts with CASP8 (By similarity). Interacts with N-APP (By similarity).
messages: Cell membrane
messages: Detected at low levels in embryonic brain. Expression is increased in newborns and during the first two weeks after birth. Expression decreases thereafter and is low after three weeks and in adult life.
messages: Detected in brain (at protein level). Detected in corpus callosum oligodendrocytes. Detected in embryonic and adult brain.
messages: Oxidized in response to reactive oxygen species (ROS), leading to endocytosis.
messages: Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B (By similarity). Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm (By similarity). Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning (By similarity). Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP) (By similarity). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) (By similarity). Negatively regulates oligodendrocyte survival, maturation and myelination (PubMed:21725297). Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation (By similarity). Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells (By similarity). Negatively regulates the production of IgG, IgM and IgM in response to antigens (By similarity). May inhibit the activation of JNK in response to T-cell stimulation (By similarity). Also acts as a regulator of pyroptosis: recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC (By similarity).

10116:Bmp8b
gene id: 10116:Bmp8b
uniprot id: A6IS17
uniprot id: D3ZWC5
names: Similarity
messages: Belongs to the TGF-beta family.

10116:Sntg2
gene id: 10116:Sntg2
uniprot id: A0A8I6A197
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

10116:Prkch
gene id: 10116:Prkch
uniprot id: A6HC64
uniprot id: Q64617
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization (By similarity).
messages: Cytoplasm
messages: Interacts with FYN (By similarity). Interacts with RALA (By similarity). Interacts with DGKQ (By similarity).
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.
messages: The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.

10116:Sin3b
gene id: 10116:Sin3b
uniprot id: A6K9M6
uniprot id: M0R4T7
names: Subcellular Location Annotation
messages: Nucleus

10116:Gpr155
gene id: 10116:Gpr155
uniprot id: A6HM90
uniprot id: A6HM91
uniprot id: D3ZWM3
names: Subcellular Location Annotation
messages: Membrane

10116:LOC100359937
gene id: 10116:LOC100359937
uniprot id: A6IZB7
uniprot id: P60522
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG8 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Monomer. Interacts with ATG3, ATG7, ATG13 and ULK1. Interacts with TP53INP1 and TP53INP2. Interacts with TBC1D25. Directly interacts with SQSTM1 and BNIP3. Interacts with TECPR2 and PCM1. Interacts with TBC1D5. Interacts with TRIM5. Interacts with MEFV and TRIM21. Interacts with WDFY3. Interacts with UBA5; promoting recruitment of UBA5 to the endoplasmic reticulum membrane. Interacts with GOSR1. Interacts with KBTBD6 and KBTBD7; the interaction is direct. Interacts with reticulophagy regulators RETREG1, RETREG2 and RETREG3. Interacts with IRGM (By similarity).
messages: Phosphorylation at Ser-87 and Ser-88 by TBK1 prevents interaction with ATG4 (ATG4A, ATG4B, ATG4C or ATG4D). Phosphorylation by TBK1 on autophagosomes prevents their delipidation by ATG4 and premature removal from nascent autophagosomes.
messages: The precursor molecule is cleaved by ATG4 (ATG4A, ATG4B, ATG4C or ATG4D) to expose the glycine at the C-terminus and form the cytosolic form, GABARAPL2-I. The processed form is then activated by APG7L/ATG7, transferred to ATG3 and conjugated to phosphatidylethanolamine (PE) phospholipid to form the membrane-bound form, GABARAPL2-II. During non-canonical autophagy, the processed form is conjugated to phosphatidylserine (PS) phospholipid. ATG4 proteins also mediate the delipidation of PE-conjugated forms required for GABARAPL2 recycling when autophagosomes fuse with lysosomes. In addition, ATG4B and ATG4D mediate delipidation of ATG8 proteins conjugated to PS during non-canonical autophagy. ATG4B constitutes the major protein for proteolytic activation (By similarity). ATG4D is the main enzyme for delipidation activity (By similarity).
messages: Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).
messages: autophagosome

10116:Hdac10
gene id: 10116:Hdac10
uniprot id: A0A8I6A775
uniprot id: A6K7J6
uniprot id: Q569C4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Cytoplasm
messages: Interacts with HDAC3. Interacts with HDAC2 and NCOR2/SMRT. Interacts with HSPA8/HSC70. Interacts with MSH2.
messages: Nucleus
messages: Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. May play a role in homologous recombination. May promote DNA mismatch repair.
messages: Protein/histone deacetylase activity in vivo is uncertain. The 3D structure analysis of the zebrafish ortholog shows that a glutamate gatekeeper and a sterically constricted active site confer specificity for N(8)-acetylspermidine hydrolysis and disfavour acetyllysine hydrolysis. Supporting this observation, has been shown to exhibit only very low activity, if any, towards acetyl-lysine peptide substrates. However, histone deacetylase activity has been observed in vitro and HDAC10 has also been shown to be involved in MSH2 deacetylation.

10116:Slc35a1
gene id: 10116:Slc35a1
uniprot id: A6IIM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

10116:Nenf
gene id: 10116:Nenf
uniprot id: Q6IUR5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival (PubMed:31536960). Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity). Neurotrophic activity is enhanced by binding to heme (By similarity). Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity).
messages: Belongs to the cytochrome b5 family. MAPR subfamily.
messages: Endoplasmic reticulum
messages: Interacts with PINK1 and PARK7.
messages: Mitochondrion
messages: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
messages: The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residue at position 81.
messages: extracellular space

10116:Ebag9
gene id: 10116:Ebag9
uniprot id: A6HRB8
uniprot id: Q5PQP2
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Golgi apparatus membrane
messages: Homodimer.
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.
messages: The coiled coil domain is necessary for the homodimerization.

10116:Tsen54
gene id: 10116:Tsen54
uniprot id: A6HKQ9
uniprot id: D3ZZT6
names: Similarity
messages: Belongs to the SEN54 family.

10116:Kctd5
gene id: 10116:Kctd5
uniprot id: B5DEL1
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homopentamer (By similarity). Interacts (via C-terminus) with GRASP55/GORASP2 (By similarity). Interacts with CUL3 and with ubiquitinated proteins (By similarity). Interacts with CRY1 (By similarity).
messages: Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex (By similarity). Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (By similarity).
messages: Nucleus
messages: The BTB (POZ) domain is atypical and mediates the formation of a homopentamer instead of a homotetramer (By similarity). Homopentamerization is due to the presence of 4 residues in the BTB (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118 (By similarity).
messages: cytosol

10116:Gna13
gene id: 10116:Gna13
uniprot id: Q6Q7Y5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Cytoplasm
messages: G proteins are composed of 3 units; alpha, beta and gamma (By similarity). The alpha chain contains the guanine nucleotide binding site (By similarity). Interacts with UBXD5 (By similarity). Interacts with HAX1 (By similarity). Interacts (in GTP-bound form) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane (PubMed:12176367). Interacts with RGS22 (By similarity). Interacts with ARHGEF1. Interacts (in GTP-bound form) with ARHGEF11 (via RGS domain) (By similarity). Interacts (in GTP-bound form) with ARHGEF12 (via RGS domain) (By similarity). Interacts (in GTP-bound form) with CTNND1 (By similarity). Interacts with GAS2L2 (By similarity).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:12176367). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (By similarity). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (By similarity). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (By similarity).
messages: Melanosome
messages: Membrane
messages: Nucleus
messages: Palmitoylation is critical for proper membrane localization and signaling.
messages: Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation.

10116:Hdgfl3
gene id: 10116:Hdgfl3
uniprot id: Q923W4
names: Function
names: Subcellular Location Annotation
messages: Enhances DNA synthesis and may play a role in cell proliferation.
messages: Nucleus

10116:Car11
gene id: 10116:Car11
uniprot id: F7FEL0
uniprot id: Q811X3
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

10116:Pygm
gene id: 10116:Pygm
uniprot id: A6HZH0
uniprot id: G3V8V3
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

10116:Pfdn1
gene id: 10116:Pfdn1
uniprot id: A6J311
uniprot id: D3ZX38
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

10116:Araf
gene id: 10116:Araf
uniprot id: A6JZR6
uniprot id: P14056
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Interacts with TH1L/NELFD.
messages: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity). Phosphorylates PFKFB2 (By similarity).

10116:Smc2
gene id: 10116:Smc2
uniprot id: D4A5Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Chromosome
messages: Nucleus

10116:Ndel1
gene id: 10116:Ndel1
uniprot id: A0A8I6AR01
uniprot id: A6HFL2
uniprot id: Q78PB6
names: Caution
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nudE family.
messages: Palmitoylation at Cys-273 reduces affinity for dynein.
messages: Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE (By similarity).
messages: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth.
messages: Self-associates. Interacts with dynactin, tubulin gamma, KATNA1, KATNB1, microtubules, PCM1, PCNT, and YWHAE. Interacts directly with NEFL and indirectly with NEFH. Interacts (via C-terminus) with CENPF. Interacts with DISC1, dynein and PAFAH1B1. Interacts with ZNF365. Interacts with PLEKHM1 (via N- and C-terminus).
messages: Up-regulated during neurite outgrowth upon differentiation with NGF.
messages: Was originally thought to function as an oligopeptidase (NUDEL-oligopeptidase or endooligopeptidase A) which could regulate peptide levels relevant to brain function.
messages: centrosome
messages: cytoskeleton
messages: kinetochore
messages: spindle

10116:S100a1
gene id: 10116:S100a1
uniprot id: A6J6N4
uniprot id: P35467
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Able to bind zinc in vitro; the binding sites are different from the calcium binding sites. The physiological relevance of zinc binding is unclear. Physiological concentrations of potassium antagonize the binding of both divalent cations, especially affecting the high-affinity calcium-binding sites.
messages: Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Also forms heterodimers with S100P (By similarity). Interacts with AGER (PubMed:19910580). Interacts with CAPZA1 (PubMed:19452629). Interacts with FKBP4. Interacts with RYR1 and RYR2 (PubMed:18650434). Interacts with CACYBP in a calcium-dependent manner. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity. Interacts with ATP2A2 and PLN in a Ca(2+)-dependent manner (By similarity). Interacts with mitochondrial F1-ATPase subunits ATP5F1A and ATP5F1B; these interactions increase F1-ATPase activity (By similarity).
messages: Glutathionylated; glutathionylation increases affinity to calcium about 10-fold.
messages: Mitochondrion
messages: Sarcoplasmic reticulum
messages: Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:18650434). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (By similarity) (PubMed:18650434).

10116:Rnf166
gene id: 10116:Rnf166
uniprot id: Q6J1I7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates. In turn, participates in different biological processes including interferon production or autophagy. Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6. Also plays a role in the early recruitment of autophagy adapters to bacteria. Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication.

10116:Nmt2
gene id: 10116:Nmt2
uniprot id: A0A8I6A9A8
uniprot id: Q700Q7
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

10116:Mnat1
gene id: 10116:Mnat1
uniprot id: A6HC54
uniprot id: Q6AZ68
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

10116:Or2a20
gene id: 10116:Or2a20
uniprot id: D4A9M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ctcf
gene id: 10116:Ctcf
uniprot id: Q9R1D1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTCF zinc-finger protein family.
messages: Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over considerable distances in the genome. Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones. Inversely, binding to target sites is prevented by CpG methylation. Plays an important role in chromatin remodeling. Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping. Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory. Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription. When bound to chromatin, it provides an anchor point for nucleosomes positioning. Seems to be essential for homologous X-chromosome pairing. May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation. May play a role in preventing the propagation of stable methylation at the escape genes from X-inacti…
messages: Chromosome
messages: Interacts with CHD8. Interacts with LLPH. Interacts with CENPE.
messages: Sumoylated on Lys-74 and Lys-699; sumoylation of CTCF contributes to the repressive function of CTCF on the MYC P2 promoter.
messages: centromere
messages: nucleoplasm

10116:P2ry6
gene id: 10116:P2ry6
uniprot id: A6I6S4
uniprot id: Q63371
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abundantly expressed in various tissues including lung, stomach, intestine, spleen, mesentery, heart, and, most prominently, aorta.
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for extracellular UTP > ADP = 2-methylthio-ATP > ADP-beta-S > ATP = ATP-gamma-S. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Functionally coupled to phospholipase C.

10116:Agap1
gene id: 10116:Agap1
uniprot id: A6JQK5
uniprot id: G3V9U1
names: Similarity
messages: Belongs to the centaurin gamma-like family.

10116:Vhl
gene id: 10116:Vhl
uniprot id: A6IBT3
uniprot id: Q64259
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VHL family.
messages: Cell membrane
messages: Component of the VBC (VHL-Elongin BC-CUL2) complex; this complex acts as a ubiquitin-ligase E3 and directs proteasome-dependent degradation of targeted proteins. Interacts with CUL2; this interaction is dependent on the integrity of the trimeric VBC complex. Interacts (via the beta domain) with HIF1A (via the NTAD domain); this interaction mediates degradation of HIF1A in normoxia and, in hypoxia, prevents ubiquitination and degradation of HIF1A by mediating hypoxia-induced translocation to the nucleus, a process which requires a hypoxia-dependent regulatory signal. Interacts with ADRB2; the interaction, in normoxia, is dependent on hydroxylation of ADRB2 and the subsequent VCB-mediated ubiquitination and degradation of ADRB2. Under hypoxia, hydroxylation, interaction with VHL, ubiquitination and subsequent degradation of ADRB2 are dramatically decreased. Interacts with RNF139, USP33 and JADE1 (By similarity). Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, ELOB and CUL2. Interacts with LIMD1 (via LIM zinc-binding 2). Interacts with AJUBA (via LIM domains) and WTIP (via LIM domains) (By similarity). Interacts with EPAS1. Interacts with CARD9 (PubMed:17936701). Interacts with DCUN1D1 independently of CUL2; this interaction engages DCUN1D1 in the VCB complex and triggers CUL2 neddylation and consequently cullin ring ligase (CRL) substrates polyubiquitylation (By similarity). Interacts with ALAS1 (hydroxylated form) (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR.
messages: Nucleus
messages: The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].

10116:Tardbp
gene id: 10116:Tardbp
uniprot id: A6IU81
uniprot id: A6IU83
uniprot id: J9JIJ9
names: Subcellular Location Annotation
messages: Nucleus

10116:Gpn1
gene id: 10116:Gpn1
uniprot id: A0A9K3Y7D6
uniprot id: B1WBZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

10116:Tas2r124
gene id: 10116:Tas2r124
uniprot id: A6IMB2
uniprot id: Q67ES5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Putative taste receptor which may play a role in the perception of bitterness.
messages: Several bitter taste receptors are expressed in a single taste receptor cell.

10116:Tm2d1
gene id: 10116:Tm2d1
uniprot id: A6JRK6
uniprot id: D3ZYF8
names: Subcellular Location Annotation
messages: Membrane

10116:Ctsg
gene id: 10116:Ctsg
uniprot id: P17977
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Cell membrane
messages: Cytoplasmic granule
messages: Lysosome
messages: Nucleus
messages: Secreted
messages: Serine protease with trypsin- and chymotrypsin-like specificity. Also displays antibacterial activity against Gram-negative and Gram-positive bacteria independent of its protease activity. Prefers Phe and Tyr residues in the P1 position of substrates but also cleaves efficiently after Trp and Leu. Shows a preference for negatively charged amino acids in the P2' position and for aliphatic amino acids both upstream and downstream of the cleavage site. Required for recruitment and activation of platelets which is mediated by the F2RL3/PAR4 platelet receptor. Binds reversibly to and stimulates B cells and CD4(+) and CD8(+) T cells. Also binds reversibly to natural killer (NK) cells and enhances NK cell cytotoxicity through its protease activity. Cleaves complement C3 (By similarity). Cleaves vimentin (By similarity). Cleaves thrombin receptor F2R/PAR1. Cleaves the synovial mucin-type protein PRG4/lubricin. Cleaves and activates IL36G which promotes expression of chemokines CXCL1 and CXLC8 in keratinocytes. Cleaves IL33 into mature forms which have greater activity than the unprocessed form. Cleaves coagulation factor F8 to produce a partially activated form. Also cleaves and activates coagulation factor F10. Cleaves leukocyte cell surface protein SPN/CD43 to releases its extracellular domain and trigger its intramembrane proteolysis by gamma-secretase, releasing the CD43 cytoplasmic tail chain (CD43-ct) which translocates to the nucleus. During apoptosis, cleaves SMARCA2/BRM to produce a 160 kDa cleavage product which localizes to the cytosol. Cleaves MBP in B cell lysosomes at '88-Phe-|-Lys-89' and '112-Phe-|-Ser-113', degrading the major immunogenic MBP epitope and preventing the activation of MBP-specific autoreactive T cells. Cleaves annexin ANXA1 and antimicrobial peptide CAMP to produce peptides which act on neutrophil N-formyl peptide receptors to enhance the release of CXCL2. Acts as a ligand for the N-formyl peptide receptor FPR1, enhancing phagocyte chemotaxis…
messages: cytosol

10116:Olr1321
gene id: 10116:Olr1321
uniprot id: A0A0G2K1Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Or51r1
gene id: 10116:Or51r1
uniprot id: A6I750
uniprot id: D4ACH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Prkn
gene id: 10116:Prkn
uniprot id: Q9JK66
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Auto-ubiquitinates in an E2-dependent manner leading to its own degradation (PubMed:23661642). Also polyubiquitinated by RNF41 for proteasomal degradation (By similarity).
messages: Belongs to the RBR family. Parkin subfamily.
messages: Endoplasmic reticulum
messages: Forms an E3 ubiquitin ligase complex with UBE2L3 or UBE2L6. Mediates 'Lys-63'-linked polyubiquitination by associating with UBE2V1. Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7. Interacts with SNCAIP. Binds to the C2A and C2B domains of SYT11. Interacts and regulates the turnover of SEPTIN5. Part of a complex, including STUB1, HSP70 and GPR37. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PRKN and GPR37, thus facilitating PRKN-mediated GPR37 ubiquitination. HSP70 transiently associates with unfolded GPR37 and inhibits the E3 activity of PRKN, whereas, STUB1 enhances the E3 activity of PRKN through promotion of dissociation of HSP70 from PRKN-GPR37 complexes. Interacts with PSMD4 and PACRG. Interacts with LRRK2. Interacts with RANBP2. Interacts with SUMO1 but not SUMO2, which promotes nuclear localization and autoubiquitination. Interacts (via first RING-type domain) with AIMP2 (via N-terminus). Interacts with PSMA7 and RNF41. Interacts with PINK1. Forms a complex with PINK1 and PARK7. Interacts with CHPF, the interaction with isoform 2 may facilitate PRKN transport into the mitochondria. Interacts with MFN2 (phosphorylated), promotes PRKN localization in dysfunctional depolarized mitochondria. Interacts with FBXO7; this promotes translocation to dysfunctional depolarized mitochondria. Interacts with ZNF746. Interacts with heat shock protein 70 family members, including HSPA1L, HSPA1A and HSPA8; interaction HSPA1L promotes translocation to damaged mitochondria. Interacts with BAG4 and, to a lesser extent, BAG5; interaction with BAG4 inhibits translocation to damaged mitochondria. Forms a complex with PRKN and PARK7. Interacts with AMBRA1 (By similarity).
messages: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Protects against mitochondrial dysfunction during cellular stress, by acting downstream of PINK1 to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components. Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy. Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires PINK1-mediated phosphorylation of both PRKN and ubiquitin. After mitochondrial damage, functions with PINK1 to mediate the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of VDAC1, respectively; polyubiquitination of VDAC1 promotes mitophagy, while monoubiquitination of VDAC1 decreases mitochondrial calcium influx which ultimately inhibits apoptosis…
messages: In the autoinhibited state the side chain of Phe-463 inserts into a hydrophobic groove in RING-0, occluding the ubiquitin acceptor site Cys-431, whereas the REP repressor element binds RING-1 and blocks its E2-binding site. Activation of PRKN requires 2 steps: (1) phosphorylation at Ser-65 by PINK1 and (2) binding to phosphorylated ubiquitin, leading to unlock repression of the catalytic Cys-431 by the RING-0 region via an allosteric mechanism and converting PRKN to its fully-active form. According to another report, phosphorylation at Ser-65 by PINK1 is not essential for activation and only binding to phosphorylated ubiquitin is essential to unlock repression. In addition, ISG15 conjugation positively regulates its ubiquitin E3 ligase activity by suppressing the intramolecular interaction that maintains its autoinhibited conformation.
messages: Largely confined to neuronal elements, including fibers and neuropil. Highly expressed at the forebrain level, in pyramidal cells of layer V, in various cortical regions and cerebellum. Expressed in the nucleus of diagonal band of Broca, nucleus basalis, bed nucleus of the stria terminalis, and olfactory tubercle. Moderate expression is seen in most neurons of the subthalamic nucleus, heart, skeletal muscle and testis. Moderate expression was found in frontal cortex, parietal cortex, cerebellum, heart, skeletal muscle and testis.
messages: Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.
messages: Mitochondrion
messages: Mitochondrion outer membrane
messages: Nucleus
messages: Phosphorylated. Activation requires phosphorylation at Ser-65 by PINK1 and binding to PINK1 phosphorylated ubiquitin. Phosphorylation at Thr-175 by PINK1 and at Thr-217 is important for mitochondrial localization.
messages: Postsynaptic density
messages: Presynapse
messages: S-nitrosylated.
messages: The RING-type 1 zinc finger domain is required to repress p53/TP53 transcription.
messages: The ubiquitin-like domain binds the PSMD4 subunit of 26S proteasomes.
messages: cytosol
messages: neuron projection

10116:Or2n1g
gene id: 10116:Or2n1g
uniprot id: D3ZLA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Esm1
gene id: 10116:Esm1
uniprot id: P97682
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions (By similarity).
messages: O-glycosylated; contains chondroitin sulfate and dermatan sulfate.
messages: Pineal gland specific.
messages: Secreted

10116:Jak3
gene id: 10116:Jak3
uniprot id: Q63272
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated, leading to regulate its activity. IL2 promotes phosphorylation on tyrosine residues, including autophosphorylation on Tyr-781 (By similarity). Dephosphorylation of Tyr-976 and Tyr-977 by PTPN2 negatively regulates cytokine-mediated signaling (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Cytoplasm
messages: Endomembrane system
messages: In contrast with the ubiquitous expression of the other JAKs, JAK3 is predominantly expressed in hematopoietic tissues.
messages: Interacts with STAM2 and MYO18A. Interacts with SHB (By similarity).
messages: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion (By similarity).
messages: Possesses two phosphotransferase domains. The second one contains the catalytic domain, while the presence of a pseudokinase domain is required for suppression of basal activity of JAK3.

10116:Icam4
gene id: 10116:Icam4
uniprot id: A6JNN3
uniprot id: D3ZP29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

10116:Slc25a5
gene id: 10116:Slc25a5
uniprot id: A6JMF9
uniprot id: Q09073
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A5/ANT2 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Probably mediates mitochondrial uncoupling in tissues that do not express UCP1. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A5/ANT2 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity).
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer (By similarity). Component of the MMXD complex, which includes CIAO1, ERCC2, CIAO2B, MMS19 and SLC25A5/ANT2. Interacts with AK4 (By similarity). Interacts with TIMM44; leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity).
messages: Monomer.
messages: Present in kidney, brain, heart, liver and skeletal muscle.
messages: The matrix-open state (m-state) is inhibited by the membrane-permeable bongkrekic acid (BKA). The cytoplasmic-open state (c-state) is inhibited by the membrane-impermeable toxic inhibitor carboxyatractyloside (CATR) (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity (By similarity).
messages: The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.
messages: Trimethylated by ANTKMT at Lys-52.

10116:Slc16a11
gene id: 10116:Slc16a11
uniprot id: B5DFC0
names: Subcellular Location Annotation
messages: Membrane

10116:Iws1
gene id: 10116:Iws1
uniprot id: A0A8I6AB64
uniprot id: A0A8I6AF19
uniprot id: Q3SWT4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IWS1 family.
messages: Interacts with SUPT6H; binds preferentially to the POLR2A-bound SUPT6H. Interacts with ALYREF/THOC4, SETD2 and PRMT5 (By similarity). Interacts with HDGFRP2 (By similarity). Interacts (via IBM motif) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (By similarity).
messages: Nucleus
messages: Phosphorylation increases its interaction with PSIP1.
messages: Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription (By similarity).

10116:Gpr150
gene id: 10116:Gpr150
uniprot id: A6I4F7
uniprot id: D3ZHL8
names: Subcellular Location Annotation
messages: Membrane

10116:Usp48
gene id: 10116:Usp48
uniprot id: A0A0G2JUQ8
uniprot id: Q76LT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Interacts with TRAF2 and RELA.
messages: Nucleus
messages: Present in the brain, in particular in the postsynaptic density and the dendritic lipid raft fractions (at protein level).
messages: Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites.

10116:Lrrn1
gene id: 10116:Lrrn1
uniprot id: Q32Q07
names: Subcellular Location Annotation
messages: Membrane

10116:Traf4
gene id: 10116:Traf4
uniprot id: B1WC90
uniprot id: F7F523
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

10116:Tom1
gene id: 10116:Tom1
uniprot id: A0A8I6ACG3
uniprot id: Q5XI21
names: Similarity
messages: Belongs to the TOM1 family.

10116:Ncdn
gene id: 10116:Ncdn
uniprot id: A6ISB5
uniprot id: O35095
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the neurochondrin family.
messages: Endosome membrane
messages: Expressed in brain and in peripheral nervous system (at protein level). Weakly expressed in neurites.
messages: Interacts with MCHR1 (By similarity). Interacts with SEMA4C. Interacts with DIAPH1 (via FH3 domain) (By similarity). Interacts with GRM5 (PubMed:20007903).
messages: Palmitoylated (PubMed:23687301). Palmitoylation by ZDHHC1, ZDHHC3 and ZDHHC11 regulates the association of NCDN with endosome membranes (PubMed:23687301). May also be palmitoylated by ZDHHC7 (PubMed:23687301).
messages: Postsynapse
messages: Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.
messages: Upon tetraethylammonium (TEA) treatment.
messages: cytosol
messages: dendrite

10116:Kcnn4
gene id: 10116:Kcnn4
uniprot id: A0A0G2K4V7
uniprot id: A1A5N3
uniprot id: C6ZGH3
uniprot id: C6ZGH4
names: Subcellular Location Annotation
messages: Membrane

10116:Pnoc
gene id: 10116:Pnoc
uniprot id: A6K6J7
uniprot id: A6K6J8
uniprot id: Q62923
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the opioid neuropeptide precursor family.
messages: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.
messages: Expressed predominantly in the spinal cord and brain, being more abundant in the hypothalamus and striatum. Also found in small amounts in ovary.
messages: Has potent analgesic activity.
messages: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.
messages: Secreted
messages: Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
messages: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

10116:Cyria
gene id: 10116:Cyria
uniprot id: A0A0G2JTE1
uniprot id: A6HAQ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

10116:Alpi
gene id: 10116:Alpi
uniprot id: A6JWK6
uniprot id: G3V8I1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

10116:P2ry10
gene id: 10116:P2ry10
uniprot id: B5DF87
names: Subcellular Location Annotation
messages: Membrane

10116:Acbd3
gene id: 10116:Acbd3
uniprot id: Q7TNY6
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Golgi apparatus membrane
messages: Interacts with the C-terminal cytoplasmic domain of giantin/GOLGB1 (By similarity). Interacts with PBR and PKA regulatory subunit RI-alpha. Does not interact with PKA regulatory subunit RI-beta nor PKA regulatory subunit RII-alpha (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B; interactions with PI4KB and with TBC1D22A and TBC1D22B are mutually exclusive. Interacts with C10ORF76 and RAB11B (By similarity).
messages: Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells. Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase.
messages: Mitochondrion
messages: The GOLD domain is essential for giantin binding.

10116:Spdye4c
gene id: 10116:Spdye4c
uniprot id: Q5RJT3
names: Similarity
messages: Belongs to the Speedy/Ringo family.

10116:Sh3gl2
gene id: 10116:Sh3gl2
uniprot id: A0A8I6GFM2
uniprot id: A6J857
uniprot id: O35179
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface.
messages: Belongs to the endophilin family.
messages: Cytoplasm
messages: Early endosome
messages: Expressed in the brain (PubMed:9341169). Expressed at low level in the kidney.
messages: Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes (By similarity).
messages: Membrane
messages: Monomer; in cytoplasm. Homodimer; when associated with membranes (By similarity). Interacts with OPHN1 (By similarity). Interacts with SYNJ1 (PubMed:9341169, PubMed:9238017, PubMed:11384986). Interacts with DNM1 (PubMed:9238017, PubMed:11384986). Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation (PubMed:11384986). Interacts with PDCD6IP (By similarity). Interacts with ATXN2 (By similarity). Interacts with ADAM9 and ADAM15 cytoplasmic tails (By similarity). Interacts with BIN2 (By similarity). Interacts with TMEM108 (By similarity). Interacts with ADGRB2 (By similarity).
messages: Presynapse
messages: The N-BAR domain binds liposomes and mediates dimerization of BAR domains upon liposome binding. It induces formation of tubules from liposomes as well as fusion of liposome tubules. Cells overexpressing Sh3gl2 show no effect on transferrin uptake.

10116:Slc35a3
gene id: 10116:Slc35a3
uniprot id: A6HVA8
uniprot id: Q6AXR5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Interacts with SLC35A2; the interaction is reduced in the presence of SLC35A4. Found in a complex with SLC35A2 and SLC35A4. Interacts with MGAT4B.
messages: Membrane
messages: O-Glcnacylation regulates the stability of SLC35A3 and the specific complex formation with MGAT4B.
messages: Transports diphosphate-N-acetylglucosamine (UDP-GlcNAc) from the cytosol into the lumen of the Golgi apparatus, functioning as an antiporter that exchanges UDP-N-acetyl-alpha-D-glucosamine for UMP. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate highly branched, multiantennary complex N-glycans and keratan sulfate. However, the exact role of SLC35A3 still needs to be elucidated, it could be a member of a catalytically more efficient multiprotein complex rather than function independently as a single transporter.

10116:Ucn2
gene id: 10116:Ucn2
uniprot id: A1YKY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

10116:Pkia
gene id: 10116:Pkia
uniprot id: A0A8I5Y0V3
uniprot id: A0A8L2Q830
uniprot id: A6IH81
uniprot id: P63249
names: Function
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
messages: Highest expression in muscle (both skeletal and cardiac) and brain.
messages: The inhibitory site contains regions very similar to the hinge regions (sites that directly interact with the enzyme active site) and 'pseudosubstrate site' of the regulatory chains; but, unlike these chains, PKI does not contain cAMP-binding sites. The arginine residues within the inhibitory site are essential for inhibition and recognition of the enzyme active site (By similarity).

10116:Nme2
gene id: 10116:Nme2
uniprot id: A6HI34
uniprot id: P19804
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6) (By similarity). Interacts with CAPN8 (By similarity). Interacts with AKAP13 (By similarity). Interacts with ITGB1BP1 (via C-terminal domain region) (By similarity). Interacts with BCL2L10 (PubMed:17532299).
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not. Exhibits histidine protein kinase activity (By similarity).
messages: Nucleus
messages: The N-terminus is blocked.
messages: lamellipodium
messages: ruffle

10116:Edn3
gene id: 10116:Edn3
uniprot id: P13207
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Endothelins are endothelium-derived vasoconstrictor peptides.
messages: Secreted

10116:Syne3
gene id: 10116:Syne3
uniprot id: A6JER9
names: Similarity
messages: Belongs to the nesprin family.

10116:Kras
gene id: 10116:Kras
uniprot id: P08644
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Interaction with SOS1 promotes exchange of bound GDP by GTP.
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (when farnesylated) with GPR31.
messages: Interacts with SOS1 (By similarity). Interacts (when farnesylated) with PDE6D; this promotes dissociation from the cell membrane (By similarity). Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14. Interacts with (when farnesylated) with GPR31 (By similarity). Interacts with RAP1GDS1 (By similarity).
messages: Palmitoylated at Lys-182, Lys-184 and Lys-185. Lysine-depalmitoylation by SIRT2 promotes its localization to endomembranes in endocytic pathways.
messages: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation (PubMed:3110778). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (By similarity).
messages: Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.
messages: cytosol

10116:Asb10
gene id: 10116:Asb10
uniprot id: A0A096MJQ3
uniprot id: B5DEZ7
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

10116:Kcnmb2
gene id: 10116:Kcnmb2
uniprot id: A0A0G2K0A6
uniprot id: A6IHN2
uniprot id: Q811Q0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily.
messages: Highly expressed in brain and heart. Also expressed in lung.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB2 per KCNMA1 tetramer (By similarity).
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex (By similarity).
messages: The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus (By similarity).

10116:Rims2
gene id: 10116:Rims2
uniprot id: Q9JIS1
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Heterodimer with PCLO. Part of a ternary complex involving PCLO and EPAC2. Interacts with RAB3C, RAB3D and RAB26 (By similarity). Binds RAB3A and RAB3B that have been activated by GTP-binding. Interacts with TSPOAP1 and RIMBP2. Interacts with PPFIA3 and PPFIA4. Interacts via its zinc finger with the first C2 domain of UNC13A. Forms a complex consisting of UNC13A, RIMS2 and RAB3A.
messages: Highly expressed in hippocampus, brain cortex, cerebellum and olfactory bulb. Detected at intermediate levels in midbrain, hindbrain and spinal cord, and at low levels in testis.
messages: Presynaptic cell membrane
messages: Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity).
messages: Synapse

10116:Tasp1
gene id: 10116:Tasp1
uniprot id: A6HQL8
uniprot id: F7F9N0
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

10116:Myoz1
gene id: 10116:Myoz1
uniprot id: A6KKP3
uniprot id: D4A7U8
names: Similarity
messages: Belongs to the myozenin family.

10116:LOC683313
gene id: 10116:LOC683313
uniprot id: Q4FZU2
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.
messages: Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17. Interacts with TCHP.
messages: There are at least six isoforms of human type II keratin-6 (K6), K6A being the most abundant representing about 77% of all forms found in epithelia.
messages: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

10116:Cyfip1
gene id: 10116:Cyfip1
uniprot id: A0A0G2K472
uniprot id: A6KD28
uniprot id: D4A8H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYFIP family.
messages: synaptosome

10116:Ptk6
gene id: 10116:Ptk6
uniprot id: A6KM34
uniprot id: D3ZDS3
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

10116:Lrrc15
gene id: 10116:Lrrc15
uniprot id: Q8R5M3
names: Induction
names: Subcellular Location Annotation
messages: By amyloid-beta.
messages: Cell membrane

10116:Tm2d3
gene id: 10116:Tm2d3
uniprot id: A0A8I6ACD9
uniprot id: A6JBN3
names: Subcellular Location Annotation
messages: Membrane

10116:Snx32
gene id: 10116:Snx32
uniprot id: F1LU14
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

10116:Trpm1
gene id: 10116:Trpm1
uniprot id: Q2WEA5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM1 sub-subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Forms nonselective divalent cation-conducting channels which mediate the influx of Na(2+), Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization (By similarity). Impermeable to zinc ions (By similarity). In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions (By similarity). Essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. Calcium channel which may play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel (By similarity).
messages: Inhibited by zinc ions.
messages: Interacts with TRPM3; the interaction results in the formation of a heteromultimeric cation channel complex (By similarity). Interacts with GPR179 (By similarity).
messages: axon

10116:Rcn3
gene id: 10116:Rcn3
uniprot id: I6L9G5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CREC family.
messages: Degraded by PCSK6 and other endoproteases including FURIN and PCSK5.
messages: Endoplasmic reticulum lumen
messages: Interacts with PCSK6 (immature form including the propeptide); probably involved in the maturation and the secretion of PCSK6.
messages: N-glycosylated.
messages: Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (By similarity). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (By similarity). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (By similarity).

10116:Epb41
gene id: 10116:Epb41
uniprot id: D3ZIP3
uniprot id: D3ZKF7
names: Subcellular Location Annotation
messages: Nucleus
messages: cell cortex
messages: cytoskeleton

10116:Agpat2
gene id: 10116:Agpat2
uniprot id: A6JTG5
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

10116:Itgb4
gene id: 10116:Itgb4
uniprot id: Q64632
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Heterodimer of an alpha and a beta subunit. Beta-4 associates with alpha-6. Interacts (via cytoplasmic region) with COL17A1 (via cytoplasmic region). Interacts (via cytoplasmic region) with DST isoform 3 (via N-terminus). Interacts (via cytoplasmic domain) with DST (via N-terminus). Interacts with RAC1. ITGA6:ITGB4 is found in a ternary complex with NRG1 and ERBB3. ITGA6:ITGB4 is found in a ternary complex with IGF1 and IGF1R. ITGA6:ITGB4 interacts with IGF2.
messages: Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.
messages: Palmitoylated by DHHC3 at several cysteines of the membrane-proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secondary association with tertaspanins (By similarity).
messages: The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site.
messages: The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230.
messages: hemidesmosome

10116:Lgals2
gene id: 10116:Lgals2
uniprot id: Q9Z144
names: Function
names: Subunit
messages: Homodimer.
messages: This protein binds beta-galactoside. Its physiological function is not yet known.

10116:Pkn3
gene id: 10116:Pkn3
uniprot id: A6JTU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Nucleus

10116:Lhx6
gene id: 10116:Lhx6
uniprot id: A0A8I6AN85
uniprot id: A6JUG7
names: Subcellular Location Annotation
messages: Nucleus

10116:Tnfsf15
gene id: 10116:Tnfsf15
uniprot id: A6J7Z3
uniprot id: Q8K3Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Promotes splenocyte alloactivation (By similarity).

10116:Mrgprb4
gene id: 10116:Mrgprb4
uniprot id: Q7TN45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
messages: Expressed strongly in newborn dorsal root ganglia, adult dorsal root ganglia and trigeminal ganlia.
messages: Membrane
messages: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).

10116:Or5p60c
gene id: 10116:Or5p60c
uniprot id: D3ZAS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Kcnt1
gene id: 10116:Kcnt1
uniprot id: A0A8I6ALJ8
uniprot id: D3ZNI9
uniprot id: F1LSG1
uniprot id: Q9Z258
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily.
messages: Cell membrane
messages: Detected in brain and brainstem, in vestibular and oculomotor nuclei, the medial nucleus of the trapezoid in the auditory system, in olfactory bulb, red nucleus, and deep cerebellar nuclei. Detected in thalamus, substantia nigra, and amygdala (at protein level). Highly expressed in the brain and kidney.
messages: Interacts (via C-terminus) with FMR1; this interaction alters gating properties of KCNT1 (By similarity). Interacts with CRBN via its cytoplasmic C-terminus (PubMed:16045448).
messages: Membrane
messages: Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro).
messages: Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity.

10116:Dmtf1
gene id: 10116:Dmtf1
uniprot id: Q66HG1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DMTF1 family.
messages: Interacts with the D-type cyclins CCND1, CCND2 and CCND3. Interaction with D-type cyclins may modulate transcriptional activation by this protein.
messages: Nucleus
messages: Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin-D2/CDK6 complexes and to a lesser extent by the cyclin-D1/CDK4 complex.
messages: Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest. Binds to the consensus sequence 5'-CCCG[GT]ATGT-3'.

10116:Scamp1
gene id: 10116:Scamp1
uniprot id: P56603
uniprot id: Q5D009
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAMP family.
messages: Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.
messages: Interacts with SLC9A7 (By similarity). Interacts with SYNRG and ITSN1.
messages: Membrane
messages: Recycling endosome membrane
messages: trans-Golgi network membrane

10116:Atl1
gene id: 10116:Atl1
uniprot id: A0A8I6GAH6
uniprot id: Q6PST4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
messages: Detected in brain where it is abundant in lamina V of the cerebral cortex. Also expressed within the hippocampus, mainly in pyramidal neurons in CA1 and CA3. Weakly expressed in the striatum and more robustly in amygdala and several thalamic nuclei. Also detected in several mesopontine nuclei (at protein level).
messages: Endoplasmic reticulum membrane
messages: Expression increases gradually from 18 dpc through adulthood.
messages: GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development.
messages: Golgi apparatus membrane
messages: Monomer as apoprotein and in the GDP-bound form. Homodimer in the GTP-bound form. Homooligomer. Interacts (via N-terminal region) with MAP4K4 (via CNH regulatory domain). Interacts with SPAST; interaction is direct (By similarity). Interacts with REEP5, RTN3 and RTN4 (via the transmembrane region) (PubMed:19665976). Interacts with REEP1 (By similarity). Interacts with CPT1C (By similarity). Interacts with ARL6IP1 (PubMed:24262037). Interacts with ZFYVE27 (By similarity).
messages: axon

10116:Or2ag19
gene id: 10116:Or2ag19
uniprot id: A6I7P9
uniprot id: M0RDA9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Atp2a1
gene id: 10116:Atp2a1
uniprot id: B4F7E5
uniprot id: Q64578
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Ca(2+) and ATP binding cause major rearrangements of the cytoplasmic and transmembrane domains. According to the E1-E2 model, Ca(2+) binding to the cytosolic domain of the pump in the high-affinity E1 conformation is followed by the ATP-dependent phosphorylation of the active site Asp, giving rise to E1P. A conformational change of the phosphoenzyme gives rise to the low-affinity E2P state that exposes the Ca(2+) ions to the lumenal side and promotes Ca(2+) release. Dephosphorylation of the active site Asp mediates the subsequent return to the E1 conformation.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Increased contractile activity leads to a decrease in SERCA1 expression, while decreased contractile activity leads to an increase in SERCA1 expression.
messages: Inhibited by sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity). Reversibly inhibited by phospholamban (PLN) at low calcium concentrations (By similarity). Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN (By similarity). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity).
messages: Interacts with sarcolipin (SLN) (By similarity). Interacts with phospholamban (PLN) (By similarity). Interacts with myoregulin (MRLN). Interacts with DWORF (By similarity). Interacts with VMP1 (By similarity).
messages: Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: PLN and SLN both have a single transmembrane helix; both occupy a similar binding site on ATP2A1 that is situated between the ATP2A1 transmembrane helices.
messages: Sarcoplasmic reticulum membrane
messages: Skeletal muscle, fast twitch muscle (type II) fibers.

10116:Lynx1
gene id: 10116:Lynx1
uniprot id: A6HRY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:RGD1564963
gene id: 10116:RGD1564963
uniprot id: A0A8I5ZXK4
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

10116:Trim39
gene id: 10116:Trim39
uniprot id: Q6MFZ5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated.
messages: Belongs to the TRIM/RBCC family.
messages: E3 ubiquitin-protein ligase (By similarity). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (By similarity). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (By similarity).
messages: Interacts with MOAP1 (By similarity). Interacts with CDKN1A (By similarity).
messages: Mitochondrion
messages: Nucleus
messages: cytosol

10116:Sec24a
gene id: 10116:Sec24a
uniprot id: A6HE75
uniprot id: D3ZZA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

10116:Vom1r103
gene id: 10116:Vom1r103
uniprot id: Q62850
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in 1-4% of neurons of the vomeronasal organ. Only one pheromone receptor gene may be expressed in a particular neuron. Not expressed in the main olfactory epithelium.
messages: Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior.

10116:Apln
gene id: 10116:Apln
uniprot id: Q9R0R3
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the apelin family.
messages: During pregnancy and lactation (PubMed:10525157).
messages: Endogenous ligand for the apelin receptor (APLNR) (PubMed:11336787, PubMed:11359874, PubMed:26611206). Drives internalization of the apelin receptor (PubMed:11359874). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (PubMed:11336787). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (By similarity). Plays a role in early coronary blood vessels formation (By similarity). Mediates myocardial contractility in an ERK1/2-dependent manner (PubMed:26611206). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (PubMed:10617103, PubMed:11359874).
messages: Expressed in the lung, testis, ovary, uterus and mammary gland (PubMed:11336787). Expressed in neurons in the thalamic paraventricular and hypothalamic supraoptic nuclei (PubMed:11359874). The lung, testis and uterus mainly contain a large form that looks like apelin-36, whereas the mammary gland seems to contain 2 forms of apelin, a large form close to apelin-36 and a small form close to apelin-13 (at protein level) (PubMed:11336787). Widely expressed in the adult, with highest levels in the mammary gland of lactating animals, very high levels in the lung, intermediate levels in the spinal cord, ovary, adipose tissue, brain (neuronal cell bodies and fibers in the supraoptic and the paraventricular nuclei), heart and testis, and lowest levels in the pituitary gland, kidney, stomach, uterus and pancreas (PubMed:10525157, PubMed:10617103, PubMed:11336787).
messages: Highly expressed in neonatal tissues. In the adult, reaches a maximal level around parturition.
messages: Secreted
messages: Several active peptides may be produced by proteolytic processing of the peptide precursor.
messages: extracellular space

10116:Efnb3
gene id: 10116:Efnb3
uniprot id: A6HFR3
uniprot id: G3V7D4
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Olr1273
gene id: 10116:Olr1273
uniprot id: A6KUG1
uniprot id: D4A8K9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Hoxb8
gene id: 10116:Hoxb8
uniprot id: A6HIE2
uniprot id: G3V6Y1
names: Subcellular Location Annotation
messages: Nucleus

10116:Lhb
gene id: 10116:Lhb
uniprot id: A0A0A0MY50
uniprot id: P01230
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
messages: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
messages: Secreted

10116:Olr879
gene id: 10116:Olr879
uniprot id: A6KSL4
uniprot id: D3ZYI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Csgalnact2
gene id: 10116:Csgalnact2
uniprot id: A6IL55
uniprot id: D4A5Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

10116:Mog
gene id: 10116:Mog
uniprot id: F6PTF1
uniprot id: Q6MFX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.

10116:Or4k42b
gene id: 10116:Or4k42b
uniprot id: A0A8I6ACW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:LOC120093098
gene id: 10116:LOC120093098
uniprot id: A0A8I5ZTS6
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

10116:Dynlt5
gene id: 10116:Dynlt5
uniprot id: A0A8I6GJS0
uniprot id: A6JRR8
uniprot id: D3Z8A1
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

10116:Dolpp1
gene id: 10116:Dolpp1
uniprot id: A6JTY4
uniprot id: D3Z917
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

10116:Tspan13
gene id: 10116:Tspan13
uniprot id: A6HBA6
uniprot id: Q5FVL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

10116:Anapc5
gene id: 10116:Anapc5
uniprot id: A1L1K3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
messages: Nucleus
messages: The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.
messages: spindle

10116:Bud31
gene id: 10116:Bud31
uniprot id: A6K1F5
uniprot id: O70454
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BUD31 (G10) family.
messages: Contains a short sequence motif (Phe-Xaa-Xaa-Phe-Tyr) that can bind to AR and may modulate AR activity.
messages: Identified in the spliceosome C complex. May interact with AR.
messages: Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity.
messages: Nucleus

10116:Amd1
gene id: 10116:Amd1
uniprot id: A6KII8
uniprot id: P17708
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

10116:Nap1l4
gene id: 10116:Nap1l4
uniprot id: A0A0H2UHZ2
uniprot id: A6HYC3
uniprot id: A6HYC4
uniprot id: Q5U2Z3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as histone chaperone in nucleosome assembly.
messages: Belongs to the nucleosome assembly protein (NAP) family.
messages: Cytoplasm
messages: Interacts with core (H2A, H2B, H3, H4) and linker (H1) histones.
messages: Nucleus
messages: Phosphorylated at the G0/G1 boundary but it is not phosphorylated in S-phase. Phosphorylated protein remains in the cytoplasm in a complex with histones during the G0/G1 transition, whereas dephosphorylation triggers its transport into the nucleus at the G1/S-boundary.
messages: Polyglutamylated and polyglycylated. These 2 modifications occur exclusively on glutamate residues and result in either polyglutamate or polyglycine chains on the gamma-carboxyl group. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Polyglutamylated by TTLL4.

10116:Foxi3
gene id: 10116:Foxi3
uniprot id: A6IA63
names: Subcellular Location Annotation
messages: Nucleus

10116:Krt7
gene id: 10116:Krt7
uniprot id: A6KCP5
uniprot id: G3V712
uniprot id: Q6IG12
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Arg-15 is dimethylated, probably to asymmetric dimethylarginine.
messages: Belongs to the intermediate filament family.
messages: Blocks interferon-dependent interphase and stimulates DNA synthesis in cells.
messages: Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10. Interacts with GPER1 (By similarity).
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

10116:Tnfsf10
gene id: 10116:Tnfsf10
uniprot id: A6IHG6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

10116:Laptm4a
gene id: 10116:Laptm4a
uniprot id: Q6P501
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAPTM4/LAPTM5 transporter family.
messages: Endomembrane system
messages: May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.
messages: The C-terminal domain is necessary for retention within intracellular membranes.

10116:Or4a77d
gene id: 10116:Or4a77d
uniprot id: D4A9N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Or5ak22
gene id: 10116:Or5ak22
uniprot id: A6HMT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Or3a4
gene id: 10116:Or3a4
uniprot id: A6HGL7
uniprot id: D4A4S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Pik3ca
gene id: 10116:Pik3ca
uniprot id: A0A0G2K344
names: Domain
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the PI3/PI4-kinase family.
messages: Detected in the hypothalamus (at protein level).
messages: Heterodimer of a catalytic subunit PIK3CA and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interacts with IRS1 in nuclear extracts. Interacts with RUFY3. Interacts with RASD2. Interacts with APPL1. Interacts with HRAS and KRAS. Interaction with HRAS/KRAS is required for PI3K pathway signaling and cell proliferation stimulated by EGF and FGF2. Interacts with FAM83B; activates the PI3K/AKT signaling cascade.
messages: Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins (PubMed:20236230). Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others (By similarity). Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity).
messages: The PI3K-ABD domain and the PI3K-RBD domain interact with the PI3K/PI4K kinase domain. The C2 PI3K-type domain may facilitate the recruitment to the plasma membrane. The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1, and the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1.

10116:Adam11
gene id: 10116:Adam11
uniprot id: A6HJM4
uniprot id: D4A6U1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Akt1
gene id: 10116:Akt1
uniprot id: A6KBV9
uniprot id: P47196
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:11882383, PubMed:21620960, PubMed:21432781). This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates (PubMed:11882383, PubMed:21620960, PubMed:21432781). Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (PubMed:11882383, PubMed:21620960, PubMed:21432781). AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (PubMed:9632753, PubMed:10400692). Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (By similarity). AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (By similarity). AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating the mTORC1 signaling pathway, and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Also regulates the mTORC1 signaling pathway by catalyzing phosphorylation of CASTOR…
messages: Acetylated on Lys-14 and Lys-20 by the histone acetyltransferases EP300 and KAT2B. Acetylation results in reduced phosphorylation and inhibition of activity. Deacetylated at Lys-14 and Lys-20 by SIRT1. SIRT1-mediated deacetylation relieves the inhibition (By similarity).
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
messages: Binding of the PH domain to phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) following phosphatidylinositol 3-kinase alpha (PIK3CA) activity results in its targeting to the plasma membrane. The PH domain mediates interaction with TNK2 and Tyr-176 is also essential for this interaction (By similarity).
messages: Cell membrane
messages: Cleavage by caspase-3/CASP3 (By similarity). Cleaved at the caspase-3 consensus site Asp-462 during apoptosis, resulting in down-regulation of the AKT signaling pathway and decreased cell survival (By similarity).
messages: Cytoplasm
messages: In light of strong homologies in the primary amino acid sequence, the 3 AKT kinases were long surmised to play redundant and overlapping roles. More recent studies has brought into question the redundancy within AKT kinase isoforms and instead pointed to isoform specific functions in different cellular events and diseases. AKT1 is more specifically involved in cellular survival pathways, by inhibiting apoptotic processes; whereas AKT2 is more specific for the insulin receptor signaling pathway. Moreover, while AKT1 and AKT2 are often implicated in many aspects of cellular transformation, the 2 isoforms act in a complementary opposing manner. The role of AKT3 is less clear, though it appears to be predominantly expressed in brain.
messages: Interacts (via the C-terminus) with CCDC88A (via its C-terminus). Interacts with GRB10; the interaction leads to GRB10 phosphorylation thus promoting YWHAE-binding. Interacts with AGAP2 (isoform 2/PIKE-A); the interaction occurs in the presence of guanine nucleotides. Interacts with AKTIP. Interacts (via PH domain) with MTCP1, TCL1A and TCL1B. Interacts with CDKN1B; the interaction phosphorylates CDKN1B promoting 14-3-3 binding and cell-cycle progression. Interacts with MAP3K5 and TRAF6. Interacts with BAD, PPP2R5B, STK3 and STK4. Interacts (via PH domain) with SIRT1. Interacts with SRPK2 in a phosphorylation-dependent manner. Interacts with TNK2 and CLK2. Interacts with RAF1. Interacts (via the C-terminus) with THEM4 (via its C-terminus). Interacts with TRIM13; the interaction ubiquitinates AKT1 leading to its proteasomal degradation. Interacts with and phosphorylated by PDPK1 (By similarity). Interacts with BTBD10 (By similarity). Interacts with KCTD20 (By similarity). Interacts with PA2G4 (PubMed:16832058). Interacts with KIF14; the interaction is detected in the plasma membrane upon INS stimulation and promotes AKT1 phosphorylation (By similarity). Interacts with FAM83B; activates the PI3K/AKT signaling cascade (By similarity). Interacts with WDFY2 (via WD repeats 1-3) (By similarity). Forms a complex with WDFY2 and FOXO1 (By similarity). Interacts with FAM168A (By similarity). Interacts with SYAP1 (via phosphorylated form and BSD domain); this interaction is enhanced in a mTORC2-mediated manner in response to epidermal growth factor (EGF) stimulation and activates AKT1 (By similarity). Interacts with PKHM3 (By similarity). Interacts with FKBP5/FKBP51; promoting interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (By similarity). Interacts with TMEM175; leading to formation of the lysoK(GF) complex (By similarity).
messages: Nucleus
messages: O-GlcNAcylation at Thr-305 and Thr-312 inhibits activating phosphorylation at Thr-308 via disrupting the interaction between AKT1 and PDPK1. O-GlcNAcylation at Ser-473 also probably interferes with phosphorylation at this site.
messages: Phosphorylation on Thr-308, Ser-473 and Tyr-474 is required for full activity (PubMed:10400692). Activated TNK2 phosphorylates it on Tyr-176 resulting in its binding to the anionic plasma membrane phospholipid PA. This phosphorylated form localizes to the cell membrane, where it is targeted by PDPK1 and PDPK2 for further phosphorylations on Thr-308 and Ser-473 leading to its activation. Ser-473 phosphorylation by mTORC2 favors Thr-308 phosphorylation by PDPK1. Phosphorylated at Thr-308 and Ser-473 by IKBKE and TBK1 (By similarity). Ser-473 phosphorylation is enhanced by signaling through activated FLT3 (By similarity). Ser-473 is dephosphorylated by PHLPP (By similarity). Dephosphorylated at Thr-308 and Ser-473 by PP2A phosphatase. The phosphorylated form of PPP2R5B is required for bridging AKT1 with PP2A phosphatase. Ser-473 is dephosphorylated by CPPED1, leading to termination of signaling (By similarity). AIM2 acts as an inhibitor of AKT1 by inhibiting phosphorylation Ser-473: AIM2 acts both by inhibiting the activity of PRKDC/DNA-PK kinase and promoting dephosphorylation by PP2A phosphatase (By similarity).
messages: The AGC-kinase C-terminal mediates interaction with THEM4.
messages: Three specific sites, one in the kinase domain (Thr-308) and the two other ones in the C-terminal regulatory region (Ser-473 and Tyr-474), need to be phosphorylated for its full activation.
messages: Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. TRAF6-induced 'Lys-63'-linked AKT1 ubiquitination is critical for phosphorylation and activation. When ubiquitinated, it translocates to the plasma membrane, where it becomes phosphorylated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome. Ubiquitinated via 'Lys-48'-linked polyubiquitination by ZNRF1, leading to its degradation by the proteasome. Also ubiquitinated by TRIM13 leading to its proteasomal degradation. Phosphorylated, undergoes 'Lys-48'-linked polyubiquitination preferentially at Lys-284 catalyzed by MUL1, leading to its proteasomal degradation (By similarity).
messages: Widely expressed. Low levels found in liver with slightly higher levels present in thymus and testis.

10116:Rprd1b
gene id: 10116:Rprd1b
uniprot id: A6JWU8
uniprot id: B5DEK0
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

10116:Lancl3
gene id: 10116:Lancl3
uniprot id: D3ZG98
names: Similarity
messages: Belongs to the LanC-like protein family.

10116:Olr937
gene id: 10116:Olr937
uniprot id: D3ZZJ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Dusp7
gene id: 10116:Dusp7
uniprot id: Q63340
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Cytoplasm
messages: Dual specificity protein phosphatase (By similarity). Shows high activity towards MAPK1/ERK2 (By similarity). Also has lower activity towards MAPK14 and MAPK8 (By similarity). In arrested oocytes, plays a role in meiotic resumption. Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB. May also inactivate PRKCA and/or PRKCG. Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex.
messages: Interacts with MAPK1/ERK2; the interaction enhances DUSP7 phosphatase activity.
messages: Strongly inhibited by sodium orthovanadate.

10116:Rpl22
gene id: 10116:Rpl22
uniprot id: P47198
uniprot id: Q6PDV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL22 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

10116:Cst3
gene id: 10116:Cst3
uniprot id: P14841
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Known to inhibit cathepsin B, H, and L.
messages: Belongs to the cystatin family.
messages: Secreted

10116:Or2r3
gene id: 10116:Or2r3
uniprot id: A6IF79
uniprot id: D3ZKH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Reg3a
gene id: 10116:Reg3a
uniprot id: P35231
names: Disease Annotation
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. In pancreas, is able to permealize beta-cells membrane and stimulate their proliferation.
messages: Appears in pancreatic juice after induction of pancreatic inflammation.
messages: Bactericidal C-type lectin. The lack of the EPN motif may explain its inability to bind peptidoglycan.
messages: Forms a hexameric membrane-permeabilizing oligomeric pore on membrane phospholipids. The hexamer is formed by three dimers related by helical symmetry. Forms filaments, filamentation traps pore complexes and limits damage to host cells. Interacts with EXTL3.
messages: Lacks the EPN motif and the presence of Gln instead of Glu at amino-acid position 114 may explain its inability to bind peptidoglycan.
messages: Low expression found in healthy pancreas.
messages: Overexpressed during the acute phase of pancreatitis.
messages: Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.
messages: Secreted

10116:Nudt22
gene id: 10116:Nudt22
uniprot id: Q6P9U1
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family.
messages: Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose.

10116:Or52e8
gene id: 10116:Or52e8
uniprot id: D3ZXV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Krt73
gene id: 10116:Krt73
uniprot id: Q6IG03
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity).
messages: Heterotetramer of two type I and two type II keratins.
messages: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

10116:Or5p56
gene id: 10116:Or5p56
uniprot id: A6I7T2
uniprot id: D3ZST0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Lzts2
gene id: 10116:Lzts2
uniprot id: F7FLS6
uniprot id: Q3LUD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Interacts with CTNNB1 (By similarity). Interacts with KATNB1. Also interacts with gamma-tubulin and KIF23.
messages: Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

10116:Csnk1d
gene id: 10116:Csnk1d
uniprot id: A6HLL8
uniprot id: Q06486
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated on serine and threonine residues; this autophosphorylation represses activity. Reactivated by phosphatase-mediated dephosphorylation. May be dephosphorylated by PP1.
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Drug-mediated inhibition leads to a delay of the oscillations with the magnitude of this effect dependent upon the timing of drug administration. Inhibited by phosphorylation (By similarity). Exhibits substrate-dependent heparin activation.
messages: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate (By similarity).
messages: Expressed in most tissues, including heart, brain, testis, kidney, spleen and lung.
messages: Golgi apparatus
messages: Monomer (By similarity). Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins (By similarity). Interacts with DNMT1 (By similarity). Interacts directly with PER1 and PER2 which may lead to their degradation (By similarity). Interacts with MAPT/TAU, SNAPIN, DBNDD2, AIB1/NCOA3 and ESR1 (By similarity). Interacts with AKAP9/AKAP450; this interaction promotes centrosomal subcellular location (By similarity). Binds to tubulins in mitotic cells upon DNA damage (By similarity). Interacts with GJA1 (By similarity). Interacts with MAP1A (PubMed:15961172). Interacts with DDX3X; this interaction enhances CSNK1D kinase activity in vitro, but it is unclear whether this interaction is physiologically relevant (By similarity).
messages: Nucleus
messages: The autoinhibitory domain is involved in regulating enzyme activity through autophosphorylation and possibly, through heparin binding.
messages: centrosome
messages: perinuclear region
messages: spindle

10116:RGD1309534
gene id: 10116:RGD1309534
uniprot id: A6JNB6
uniprot id: Q5U2Q3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

10116:Slc66a1
gene id: 10116:Slc66a1
uniprot id: B0BMY1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes.
messages: Belongs to the laat-1 family.
messages: Lysosome membrane
messages: The di-leucine motif mediates lysosomal localization.

10116:S1pr3
gene id: 10116:S1pr3
uniprot id: F1M9D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Mterf4
gene id: 10116:Mterf4
uniprot id: A6JQY2
uniprot id: Q4G078
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mTERF family.
messages: Heterodimer with NSUN4; this interaction may be required for NSUN4 recruitment to the mitochondrial large ribosomal subunit.
messages: Mitochondrion
messages: Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (By similarity).
messages: The MTERF repeats form a half-donut shaped, right-handed superhelix, where the concave side displays a positively charged path for nucleic acid interaction.

10116:Dpp3
gene id: 10116:Dpp3
uniprot id: O55096
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.
messages: Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (By similarity). Also cleaves Arg-Arg-beta-naphthylamide.
messages: Cytoplasm
messages: Inhibited by spinorphin, an opioid peptide derived from hemoglobin.

10116:Brca1
gene id: 10116:Brca1
uniprot id: A6HJD2
uniprot id: G3V8S5
uniprot id: O54952
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated, undergoes 'Lys-6'-linked polyubiquitination. 'Lys-6'-linked polyubiquitination does not promote degradation.
messages: Chromosome
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.
messages: Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1 (By similarity). Interacts with EXD2 (By similarity). Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme (By simila…
messages: Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1. Interacts with EXD2. Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme.
messages: Nucleus
messages: Phosphorylated in response to IR, UV, and various stimuli that cause checkpoint activation, probably by ATM or ATR. Phosphorylation at Ser-975 by CHEK2 regulates mitotic spindle assembly. Phosphorylation by AURKA regulates centrosomal microtubule nucleation.
messages: The BRCT domains recognize and bind phosphorylated pSXXF motif on proteins. The interaction with the phosphorylated pSXXF motif of ABRAXAS1, recruits BRCA1 at DNA damage sites.
messages: The RING-type zinc finger domain interacts with BAP1.

10116:Fam13a
gene id: 10116:Fam13a
uniprot id: A0A8I6GAZ0
uniprot id: A6K145
uniprot id: D3ZA02
names: Similarity
messages: Belongs to the FAM13 family.

10116:Ryr2
gene id: 10116:Ryr2
uniprot id: B0LPN4
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR2 subfamily.
messages: Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2798 and Ser-2804 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca(2+) levels (By similarity).
messages: Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.
messages: Detected in heart muscle myocytes (at protein level). Widely expressed. Detected in heart muscle and cerebral artery smooth muscle. Detected in pancreatic islet cells.
messages: Homotetramer. Can also form heterotetramers with RYR3. Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with FKBP1B, PKA, PP1 and PP2A (By similarity). Interacts with FKBP1A and FKBP1B; these interactions may stabilize the channel in its closed state and prevent Ca(2+) leaks. Interacts with CALM and S100A1; these interactions regulate channel activity. Interacts with SELENON (By similarity). In cardiac muscles, identified in a complex composed of FSD2, CMYA5 and RYR2 (By similarity).
messages: Phosphorylation at Ser-2021 by PKA enhances the response to lumenal calcium.
messages: Sarcoplasmic reticulum membrane
messages: The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.
messages: The calcium release is activated by increased cytosolic calcium levels, by nitric oxyde (NO), caffeine and ATP. Channel activity is modulated by the alkaloid ryanodine that binds to the open Ca-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). Channel activity is inhibited by magnesium ions, possibly by competition for calcium binding sites.

10116:Rrp8
gene id: 10116:Rrp8
uniprot id: A6I7L7
uniprot id: Q5U4F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8.
messages: Component of the eNoSC complex.
messages: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.
messages: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown (By similarity).
messages: nucleolus

10116:Cp
gene id: 10116:Cp
uniprot id: A0A8I6A708
uniprot id: A6IHC3
uniprot id: A6IHC4
uniprot id: G3V7K3
names: Similarity
messages: Belongs to the multicopper oxidase family.

10116:Afmid
gene id: 10116:Afmid
uniprot id: A6HL34
uniprot id: M0RC77
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
messages: Homodimer.
messages: Nucleus
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
messages: cytosol

10116:Slc16a7
gene id: 10116:Slc16a7
uniprot id: Q63344
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Cytoplasm
messages: Detected in brain and kidney (at protein level).
messages: Homodimer (By similarity). Interacts with GRID2IP (By similarity). Interacts with EMB; interaction mediates SLC16A7 targeting to the plasma membrane (PubMed:15917240, PubMed:20695846). Interacts with isoform 2 of BSG (By similarity).
messages: Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:10417314, PubMed:20695846). Dimerization is functionally required and both subunits work cooperatively in transporting substrate (By similarity).
messages: Transport activity exhibits steep dependence on substrate concentration. Substrate concentration sensitivity of SLC16A7 arises from the strong inter-subunit cooperativity of the SLC16A7 dimer during transport. Inhibited by AR-C155858.

10116:Spdef
gene id: 10116:Spdef
uniprot id: B2RYE0
uniprot id: F7EQE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

10116:Serpinb2
gene id: 10116:Serpinb2
uniprot id: A6JSV9
uniprot id: P29524
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: Cytoplasm
messages: Inhibits urokinase-type plasminogen activator.
messages: Interacts with PSMB1.
messages: The signal sequence is not cleaved.
messages: extracellular space

10116:Ces1f
gene id: 10116:Ces1f
uniprot id: Q64573
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Endoplasmic reticulum
messages: Expressed in liver and kidney.
messages: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes retinyl esters (PubMed:12230550). Hydrolyzes p-nitrophenyl butyrate (PNPB), triacylglycerol and monoacylglycerol. Shows higher activity against PNPB, a short-chain fatty acid ester, than against triolein, a long-chain fatty acid ester. Shows no detectable activity against diacylglycerol, cholesterol ester or phospholipids. May play a role in adipocyte lipolysis (By similarity).
messages: Lipid droplet
messages: Microsome
messages: cytosol

10116:Tspan12
gene id: 10116:Tspan12
uniprot id: Q569A2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Component of a complex, at least composed of TSPAN12, FZD4 and norrin (NDP) (By similarity). Interacts (when palmitoylated) with ADAM10. Interacts with MMP14/MT1-MMP (By similarity).
messages: Palmitoylated; required for interaction with ADAM10. The precise position of palmitoylated residues is unclear and occurs either on Cys-9, Cys-12 and/or Cys-83 (By similarity).
messages: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activates the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity (By similarity).

10116:Ccr1
gene id: 10116:Ccr1
uniprot id: A6I4C9
uniprot id: Q6AY38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

10116:Kdm6b
gene id: 10116:Kdm6b
uniprot id: A6HFR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTX family.
messages: Nucleus

10116:Cntfr
gene id: 10116:Cntfr
uniprot id: A0A8I5Y668
uniprot id: A6IIW4
uniprot id: Q08406
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.
messages: Binds to CNTF. The alpha subunit provides the receptor specificity.
messages: Cell membrane
messages: Forms a heterotrimer with LIFR and IL6ST. Interacts with heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1. Either alone or in complex with the heterodimer CLCF1-CRLF1 interacts with SORL1; this interaction may promote internalization and lysosomal degradation.
messages: Nervous system.
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

10116:Ybx3
gene id: 10116:Ybx3
uniprot id: Q62764
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in the skeletal muscle, spleen and fetal liver.
messages: Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity).
messages: Cytoplasm
messages: Found in a mRNP complex with YBX2. Interacts with RRP1B.
messages: Nucleus

10116:Fcnb
gene id: 10116:Fcnb
uniprot id: A6JTM2
uniprot id: P57756
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ficolin lectin family.
messages: Homotrimer. Interacts with elastin. Interacts with MASP1 and MASP2.
messages: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin (By similarity).
messages: Secreted
messages: The fibrinogen-like domain (FBG) contains calcium-binding sites that may be involved in carbohydrate binding.

10116:Rfx3
gene id: 10116:Rfx3
uniprot id: A6I0T9
names: Subcellular Location Annotation
messages: Nucleus

10116:Rspo1
gene id: 10116:Rspo1
uniprot id: A6IS66
uniprot id: D3ZBD1
names: Similarity
messages: Belongs to the R-spondin family.

10116:Megf11
gene id: 10116:Megf11
uniprot id: F1LVJ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Ubald1
gene id: 10116:Ubald1
uniprot id: Q6AXN0
names: Similarity
messages: Belongs to the UBALD family.

10116:Zkscan7
gene id: 10116:Zkscan7
uniprot id: E9PTG0
names: Subcellular Location Annotation
messages: Nucleus

10116:Il7r
gene id: 10116:Il7r
uniprot id: A6KGJ9
uniprot id: D4A3X8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
messages: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

10116:Ebna1bp2
gene id: 10116:Ebna1bp2
uniprot id: M0R7R4
uniprot id: Q5M920
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: Required for the processing of the 27S pre-rRNA.
messages: nucleolus

10116:Phf19
gene id: 10116:Phf19
uniprot id: A6JUD9
uniprot id: F1M1Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

10116:Olr1164
gene id: 10116:Olr1164
uniprot id: M0RD46
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Tcf3
gene id: 10116:Tcf3
uniprot id: P21677
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity.
messages: Forms a heterodimer with ATOH7; required for ATOH7 DNA-binding.
messages: Homodimer. Heterodimer; efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TWIST1 and TWIST2. Forms a heterodimer with NEUROD1; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E-box element. Forms a heterodimer with TCF15; the heterodimer binds E-box element. Forms a heterodimer with MYOG; heterodimerization enhances MYOG DNA-binding and transcriptional activities. Forms a heterodimer with ATOH8; repress transcription of TCF3 and TCF3-NEUROG3 dimer-induced transactivation of E box-dependent promoters. Component of a nuclear TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Interacts with NEUROD2 (By similarity). Interacts with EP300 (By similarity). Interacts with PTF1A, TGFB1I1 (By similarity). Interacts with UBE2I (PubMed:9013644). Interacts with BHLHA9 (By similarity). Interacts with ASB2; the interaction is mediated by SKP2 and targets TCF3 for Notch-induced proteasomal degradation (By similarity). Interacts with transcription factor ASCL5/AmeloD (By similarity).
messages: Interacts with RALGAPA1 (By similarity). Interacts with FIGLA (By similarity).
messages: Nucleus
messages: Phosphorylated following NGF stimulation.
messages: Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (By similarity). Binds to the consensus sequence CAC/GCTGT/C present, in the chymotrypsin, insulin, AP-4, and several other gene enhancer motifs (PubMed:2200736).
messages: Undergoes Notch-induced ubiquitination and subsequent proteasomal degradation which is mediated by ASB1 or ASB2, the substrate-recognition components of probable ECS E3 ubiquitin-protein ligase complexes.

10116:Pwwp3a
gene id: 10116:Pwwp3a
uniprot id: A0A8L2QRY6
uniprot id: B1H224
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PWWP3A family.
messages: Interacts with TP53BP1 (via BRCT domain); the interaction is not dependent on its phosphorylation status. Binds nucleosomes. Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3) (in vitro) (By similarity).
messages: Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage (By similarity).
messages: Nucleus
messages: The PWWP domain mediates the interaction with nucleosomes.

10116:Afdn
gene id: 10116:Afdn
uniprot id: O35889
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (PubMed:9334353). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:9334353). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (By similarity).
messages: Homodimer. Interacts with F-actin, nectin and NECTIN3. Essential for the association of nectin and E-cadherin. Isoform 2/s-afadin does not interact with F-actin. Interacts with ZO-1 and occludin, but probably in an indirect manner. Interacts with RIT1, RIT2, NRXN1 and BCR (By similarity). Interacts with ADAM10; the interaction locks ADAM10 at adherens junctions following ADAM10 recruitment to adherens junctions by TSPAN33 (PubMed:30463011).
messages: Isoform 1 increases the viscosity of F-actin in a dose-dependent manner. Isoform 1 causes F-actin to associate into bundles and meshworks.
messages: Isoform 1 is widely expressed, including in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Isoform 2 is mainly expressed in the brain.
messages: adherens junction

10116:Kcnmb4
gene id: 10116:Kcnmb4
uniprot id: B1WBP1
uniprot id: Q9ESK8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB4 subfamily.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer. Interacts with FMR1 (via N-terminus).
messages: Membrane
messages: N-glycosylated.
messages: N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin (By similarity).
messages: Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics (By similarity).
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations (By similarity).
messages: Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain.

10116:Tek
gene id: 10116:Tek
uniprot id: A6JRG8
uniprot id: D3ZCD0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Rps10
gene id: 10116:Rps10
uniprot id: A6JJM8
uniprot id: P63326
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS10 family.
messages: Component of the 40S ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Component of the small ribosomal subunit. The methylated form interacts with NPM1.
messages: Cytoplasm
messages: Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation.
messages: Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide. Deubiquitinated by OTUD3 and USP21, antagonizing ZNF598 activity. Deubiquitinated by OTUD1, antagonizing ZNF598 activity and stimulating formation of polysomes: deubiquitination by OTUD1 promotes stability and translation of a subset mRNAs with a high abundance of rare codons can limit the translation rate. Deubiquitinated by USP10.
messages: nucleolus

10116:Hoxa4
gene id: 10116:Hoxa4
uniprot id: E9PT77
names: Subcellular Location Annotation
messages: Nucleus

10116:Susd6
gene id: 10116:Susd6
uniprot id: A0A096MK85
uniprot id: A6JDK3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Cgrrf1
gene id: 10116:Cgrrf1
uniprot id: P97587
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Able to inhibit growth in several cell lines.
messages: By p53.
messages: Endoplasmic reticulum
messages: Highly expressed in testis, lower levels of expression is seen in skeletal muscle, liver, lung and brain.
messages: Nucleus

10116:Tubgcp6
gene id: 10116:Tubgcp6
uniprot id: A6K7J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: centrosome

10116:Sstr1
gene id: 10116:Sstr1
uniprot id: A6HBQ4
uniprot id: P28646
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Brain, pituitary, islet, jejunum, stomach, heart, spleen.
messages: Cell membrane
messages: Membrane
messages: Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled to phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.

10116:Snx15
gene id: 10116:Snx15
uniprot id: Q4V896
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sorting nexin family.
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Homodimer. Interacts with SNX1, SNX2 and SNX4 (By similarity).
messages: May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity).
messages: Membrane
messages: The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.

10116:Tln1
gene id: 10116:Tln1
uniprot id: A0A8I6ABG6
uniprot id: A6IJ32
uniprot id: G3V852
names: Subcellular Location Annotation
messages: cytoskeleton

10116:Olr905
gene id: 10116:Olr905
uniprot id: A0A8I5Y731
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Phka1
gene id: 10116:Phka1
uniprot id: A0A096MJF7
uniprot id: A0A096MJV9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

10116:Rragd
gene id: 10116:Rragd
uniprot id: A0A9K3Y831
uniprot id: B2RZ38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome
messages: Lysosome membrane

10116:Nadsyn1
gene id: 10116:Nadsyn1
uniprot id: A0A9K3Y6U7
uniprot id: Q812E8
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the final step of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway, the ATP-dependent amidation of deamido-NAD using L-glutamine as a nitrogen source.
messages: Homohexamer.
messages: In the C-terminal section; belongs to the NAD synthetase family.

10116:Smim5
gene id: 10116:Smim5
uniprot id: A6HKS2
uniprot id: M0R3V6
names: Subcellular Location Annotation
messages: Membrane

10116:Mzt2b
gene id: 10116:Mzt2b
uniprot id: A6JSR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOZART2 family.
messages: centrosome
messages: spindle

10116:Hacd3
gene id: 10116:Hacd3
uniprot id: A6J5D7
uniprot id: D4ABI7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Rala
gene id: 10116:Rala
uniprot id: P63322
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Cleavage furrow
messages: Higher levels where found in testes followed by brain, adrenal gland, pituitary gland, ovary, liver and kidney. Low expression was found in muscle.
messages: Interacts (via effector domain) with RALBP1; during mitosis, recruits RALBP1 to the mitochondrion where it promotes DNM1L phosphorylation and mitochondrial fission (PubMed:7623849). Interacts with EXOC2/Sec5 and EXOC8/Exo84; binding to EXOC2 and EXOC8 is mutually exclusive. Interacts with Clostridium exoenzyme C3. Interacts with RALGPS1. Interacts with LPAR1 and LPAR2. Interacts with GRK2 in response to LPAR1 activation. RALA and GRK2 binding to LPAR1 is mutually exclusive (By similarity). Interacts with CDC42 (PubMed:7623849).
messages: Midbody ring
messages: Mitochondrion
messages: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (By similarity). The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (By similarity). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (By similarity). During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 (By similarity).
messages: Phosphorylated. Phosphorylation at Ser-194 by AURKA/Aurora kinase A, during mitosis, induces RALA localization to the mitochondrion where it regulates mitochondrial fission.
messages: Prenylation is essential for membrane localization.

10116:Slc44a4
gene id: 10116:Slc44a4
uniprot id: Q6MG71
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the CTL (choline transporter-like) family.
messages: Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (By similarity).
messages: Highly expressed in intestine, kidney and stomach. Also expressed in testis and lung.
messages: Membrane
messages: N-glycosylated; N-glycosylation of Asn-67 and Asn-391 is required for a proper thiamine pyrophosphate uptake.

10116:Fabp6
gene id: 10116:Fabp6
uniprot id: P80020
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). Stimulates gastric acid and pepsinogen secretion (By similarity).
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Can bind at least two ligands per molecule, however, the stoichiometry is debated.
messages: Membrane
messages: Predominantly expressed in ileum; also expressed in ovary.

10116:Setd7
gene id: 10116:Setd7
uniprot id: A6JV72
uniprot id: D4ADE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.
messages: Nucleus

10116:Fam151b
gene id: 10116:Fam151b
uniprot id: A6I4R1
uniprot id: F7EMX6
names: Similarity
messages: Belongs to the FAM151 family.

10116:Slc22a3
gene id: 10116:Slc22a3
uniprot id: A6KJX6
uniprot id: O88446
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Cell membrane
messages: Contains one proline-rich sequence (Pro-Glu-Ser-Pro-Arg) that is required for transport activity.
messages: Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:9830022, PubMed:12538837, PubMed:16581093, PubMed:23458604). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (PubMed:9632645, PubMed:9830022). Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter (PubMed:9830022). Implicated in neuronal monoamine neurotransmitters cellular uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain (PubMed:9830022, PubMed:16581093, PubMed:19416912). Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency (By similarity). May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow (By similarity). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (PubMed:17616214). Mediates the transport of polyamine spermidine and putrescine (PubMed:23458604, PubMed:12538837). Mediates the bidirectional transport of polyamine agmatine (PubMed:12538837). Also transports guanidine (PubMed:9632645). May also mediate intracellular transport of organic cations, thereby playing a role in amine metabolism and intracellular signaling (PubMed:27659446).
messages: Endomembrane system
messages: Highly expressed in placenta (PubMed:9632645, PubMed:9830022). Expressed in intestine, hear, kidney and lung (PubMed:9632645). Widely expressed in brain, particularly in hippocampus, cerebellum, cerebral cortex (PubMed:9632645, PubMed:9830022). In the brain, expressed predominantly in regions located at the brain-cerebrospinal fluid border, with expression extending to regions that belong to monoaminergic pathways such as raphe nuclei, striatum and thalamus (PubMed:16581093). In brain, expressed in neurons and glial cells of amygdala (PubMed:27659446). Expression is low in kidney and lung and undetectable in liver. Expressed in Sertoli cells in testis (PubMed:17616214). Expressed in tracheal and bronchial epithelium of the respiratory tract, where it localizes to the apical membrane of ciliated and brush cells, and in basal cells (PubMed:15817714).
messages: Mediates the uptake of clinically used drugs including neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) and platinum-based drug oxaliplatin (PubMed:9830022, PubMed:12538837, PubMed:16581093, PubMed:18513366, PubMed:19416912, PubMed:23458604). Plays a role in the anticancer activity of oxaliplatin and may contribute to antitumor specificity (By similarity).
messages: Mitochondrion membrane
messages: Nucleus membrane
messages: Nucleus outer membrane

10116:Slc17a1
gene id: 10116:Slc17a1
uniprot id: A0A9K3Y819
uniprot id: Q6AZ46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
messages: Membrane

10116:B3galnt2
gene id: 10116:B3galnt2
uniprot id: A0A8I6GEP1
uniprot id: A0A8I6GHC5
uniprot id: A6K9D8
uniprot id: D3Z9C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

10116:Gpr85
gene id: 10116:Gpr85
uniprot id: A6IE06
uniprot id: P60895
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Interacts with DLG4 and DLG3.
messages: Membrane
messages: Orphan receptor.

10116:Defb22
gene id: 10116:Defb22
uniprot id: F7EMH3
uniprot id: Q99JD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

10116:Cyp39a1
gene id: 10116:Cyp39a1
uniprot id: A6JJ27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

10116:Art1
gene id: 10116:Art1
uniprot id: A6I716
uniprot id: D3ZJK0
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

10116:Actbl2
gene id: 10116:Actbl2
uniprot id: A6I5M8
uniprot id: D3ZRN3
names: Similarity
messages: Belongs to the actin family.

10116:Rnaseh2b
gene id: 10116:Rnaseh2b
uniprot id: A6K6C8
uniprot id: Q5XI96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H2 subunit B family.
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity).
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus
messages: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.

10116:Oc90
gene id: 10116:Oc90
uniprot id: A6HRQ7
uniprot id: D3Z9Z1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

10116:Stc1
gene id: 10116:Stc1
uniprot id: A6HTG7
uniprot id: P97574
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.
messages: Secreted
messages: Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.

10116:Slc36a2
gene id: 10116:Slc36a2
uniprot id: Q8K415
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Cell membrane
messages: Electrogenic proton/amino acid symporter with a high selectivity for the small side chains amino acids glycine, alanine and proline, where both L- and D-enantiomers are transported. Extension of the backbone length, as in beta-alanine and 4-aminobutanoate or methylation of the amino group, as in sarcosine and N,N-dimethylglycine, are also tolerated but decrease transport efficiency. A free carboxyl group is preferred.
messages: Endoplasmic reticulum membrane
messages: Expressed in lung and spleen, and to a lower extent in brain, heart, kidney and skeletal muscle.
messages: Inhibited by L- and D-pipecolic acid, nipecotic acid, isonipecotic acid, L- and D-cycloserine, and L-2-azetidine-carboxylate.
messages: Recycling endosome membrane

10116:Gpd1l
gene id: 10116:Gpd1l
uniprot id: D3ZAP9
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

10116:Or56b2b
gene id: 10116:Or56b2b
uniprot id: D3ZXX1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Or11g27
gene id: 10116:Or11g27
uniprot id: A0A8I6GE25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Mospd1
gene id: 10116:Mospd1
uniprot id: A0A8I5Y568
uniprot id: A6KUJ2
uniprot id: Q5RJS6
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation.

10116:Krt34
gene id: 10116:Krt34
uniprot id: A0A0G2K8J9
uniprot id: A6HIZ9
names: Similarity
messages: Belongs to the intermediate filament family.

10116:Or1j1
gene id: 10116:Or1j1
uniprot id: A6JUH8
uniprot id: D3Z9I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Acad11
gene id: 10116:Acad11
uniprot id: B3DMA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain.
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homodimer.
messages: Mitochondrion membrane
messages: Peroxisome

10116:Ntng1
gene id: 10116:Ntng1
uniprot id: A0A8I5YBS1
uniprot id: A0A8I6ARQ4
uniprot id: A0A8I6GA33
uniprot id: A6HV43
uniprot id: A6HV45
uniprot id: A6HV46
uniprot id: A6HV47
uniprot id: F1LWK9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Rpa3
gene id: 10116:Rpa3
uniprot id: A6IDX0
uniprot id: D4A845
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

10116:Wnt7b
gene id: 10116:Wnt7b
uniprot id: Q5NSW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

10116:Polr3g
gene id: 10116:Polr3g
uniprot id: A6I4J0
uniprot id: D4A1K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Nucleus

10116:Ccr2
gene id: 10116:Ccr2
uniprot id: A6I4D2
uniprot id: O55193
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in lung, spleen, kidney, thymus and macrophages.
messages: In animals in which experimental allergic encephalomyelitis (EAE) has been induced.
messages: Interacts with ARRB1 (By similarity). Interacts (via extracellular N-terminal region) with beta-defensin DEFB106A/DEFB106B; this interaction may preferentially require specific tyrosine sulfation on CCR2 (By similarity). Interacts with NUP85; the interaction is required for CCR2 clusters formation on the cell membrane and CCR2 signaling (By similarity).
messages: Key functional receptor for CCL2 but can also bind CCL7 and CCL12 (By similarity). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (By similarity). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (By similarity). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity). Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity).
messages: Membrane
messages: N-glycosylated.
messages: Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form (By similarity). Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer (By similarity).

10116:Cemip2
gene id: 10116:Cemip2
uniprot id: A0A0G2JZA7
uniprot id: A6I0M8
uniprot id: D3ZZ19
names: Similarity
messages: Belongs to the CEMIP family.

10116:Vps50
gene id: 10116:Vps50
uniprot id: F1LSG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
messages: Belongs to the syndetin family.
messages: Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin (By similarity). The EARP complex interacts with EIPR1 (PubMed:27191843, PubMed:27440922). Interacts with VPS51 and VPS53 in an EIPR1-independent manner (By similarity).
messages: Expressed in the brain (at protein level).
messages: Membrane
messages: Recycling endosome

10116:Sema3f
gene id: 10116:Sema3f
uniprot id: A6I309
uniprot id: D3ZGX9
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Tmem132a
gene id: 10116:Tmem132a
uniprot id: Q80WF4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TMEM132 family.
messages: Detected in the brain at 12 dpc with increasing level reaching a peak within 2 weeks after birth.
messages: Endoplasmic reticulum membrane
messages: Expressed in the brain in neuronal cells of the hypothalamus, thalamus, cerebral cortex, amygdala, and cerebellum.
messages: Golgi apparatus membrane
messages: Interacts with HSPA5/GRP78.
messages: May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation.

10116:P2rx1
gene id: 10116:P2rx1
uniprot id: A0A0G2K5F9
uniprot id: A6HGH3
uniprot id: A6HGH4
uniprot id: B7U2F3
uniprot id: P47824
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the P2X receptor family.
messages: By irradiation and dexamethasone (in thymocytes).
messages: Expressed during apoptosis in thymocytes.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: High levels in vas deferens and urinary bladder. Lower extent in spinal cord, coeliac ganglion, lung and spleen (probably in the smooth muscle part of both organs).
messages: Homo- or heteropolymers.
messages: Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

10116:Lancl1
gene id: 10116:Lancl1
uniprot id: A6KFE1
uniprot id: Q9QX69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the LanC-like protein family.
messages: Cell membrane
messages: Cytoplasm
messages: Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione (By similarity).
messages: Interacts with the C-terminal of STOM (By similarity). Interacts with the EPS8 SH3 domain. Interaction with EPS8 is inhibited by glutathione binding (By similarity).
messages: Strongly expressed in the brain, testis and skeletal muscle. Expressed in the neurons of the cerebellum, the germinal cells of the seminiferous tubules in testis, in liver hepoatocytes and in cardiac myocytes.

10116:Or8u8
gene id: 10116:Or8u8
uniprot id: A6HMW2
uniprot id: M0RB81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Uqcc1
gene id: 10116:Uqcc1
uniprot id: M0RAB6
uniprot id: Q32Q54
names: Similarity
messages: Belongs to the CBP3 family.

10116:Micos10
gene id: 10116:Micos10
uniprot id: B2RYW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13 (By similarity). This complex was also known under the names MINOS or MitOS complex (By similarity). The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (By similarity). The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with IMMT/MIC60 and MICOS13/MIC13 (By similarity). Interacts with APOO/MIC23/MIC26 and APOOL/MIC27 (By similarity). Interacts with ARMC1 (By similarity).
messages: Mitochondrion inner membrane

10116:Cd82
gene id: 10116:Cd82
uniprot id: A0A8I5ZZR7
uniprot id: A6HNI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

10116:Tcf4
gene id: 10116:Tcf4
uniprot id: Q62655
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin. Interacts with HIVEP2. Interacts with NEUROD2 (By similarity). Interacts with AGBL1 (By similarity).
messages: Nucleus
messages: Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Interacts with the CCAAT displacement protein (CDP2) to bind the tyrosine hydroxylase enhancer.

10116:Amph
gene id: 10116:Amph
uniprot id: O08838
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer with BIN1 (PubMed:9341169). Binds SH3GLB1 (By similarity). Interacts with REPS1 and SGIP1 (By similarity). Binds AP2A2 (PubMed:10380931, PubMed:10430869). Interacts with AP2B1 (PubMed:16516836, PubMed:16903783). Interacts with DNM1 and SYNJ1 (PubMed:9341169).
messages: May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity).
messages: cytoskeleton
messages: synaptic vesicle membrane

10116:Or5ak24
gene id: 10116:Or5ak24
uniprot id: A6HMT9
uniprot id: D3ZGH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Pbx1
gene id: 10116:Pbx1
uniprot id: A0A8I5ZR45
uniprot id: A0A8I6AM04
uniprot id: B1WC30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

10116:Tas2r13
gene id: 10116:Tas2r13
uniprot id: Q9JKT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

10116:Prl7d1
gene id: 10116:Prl7d1
uniprot id: F7F8M3
uniprot id: Q9R005
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

10116:Hibadh
gene id: 10116:Hibadh
uniprot id: A6K0S4
uniprot id: P29266
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.
messages: Higher level in kidney, liver, and heart than in muscle.
messages: Homodimer.
messages: Mitochondrion

10116:Hnrnpl
gene id: 10116:Hnrnpl
uniprot id: F1LQ48
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with HNRNPLL. Interacts with APEX1; the interaction is DNA-dependent. Component of a complex with SETD2 (By similarity). Interacts with ELAVL1 (PubMed:18161049). Part of a transcription inhibitory ribonucleoprotein complex composed at least of the circular RNA circZNF827, ZNF827 and HNRNPK (By similarity). Interacts with CHD8 in an RNA-dependent manner.
messages: Phosphorylation at Ser-578 by CaMK4 enhances interaction with a CaMK4-responsive RNA element (CaRRE1), and prevents inclusion of the stress axis-regulated exon (STREX) of the KCNMA1 potassium channel transcripts upon membrane depolarization.
messages: RRM domain 2 has moderate RNA-binding affinity. RRM domains 3 and 4 may facilitate RNA looping when binding to two appropriately separated binding sites within the same target pre-mRNA.
messages: Several isoelectric forms of the L protein are probably the results of post-translational modifications.
messages: Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8.
messages: nucleoplasm

10116:Tle1
gene id: 10116:Tle1
uniprot id: A0A8I6A8I5
uniprot id: A0A8I6AT29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

10116:Aip
gene id: 10116:Aip
uniprot id: Q5FWY5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.
messages: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.

10116:Nudt11
gene id: 10116:Nudt11
uniprot id: A6KPC5
uniprot id: D3ZYH3
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

10116:Or8k30b
gene id: 10116:Or8k30b
uniprot id: A0A0G2JU54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ptprj
gene id: 10116:Ptprj
uniprot id: A0A0G2JXZ9
uniprot id: A6HN64
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

10116:Or4k37
gene id: 10116:Or4k37
uniprot id: A0A8I6A6U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Cavin2
gene id: 10116:Cavin2
uniprot id: A6INX7
uniprot id: Q66H98
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAVIN family.
messages: Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine (By similarity).
messages: Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN. Interacts with CAVIN4; this augments the transactivation of NPPA by CAVIN4 (By similarity). Binds to PRKCA in the presence of phosphatidylserine (PubMed:9566962). Interacts with CAVIN1 and CAV3 (By similarity).
messages: Phosphorylated on Ser residues.
messages: Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells (By similarity). May play a role in targeting PRKCA to caveolae (PubMed:9566962).
messages: The N-terminus is blocked.
messages: The leucine-zipper domain is essential for its localization in the caveolae.
messages: caveola
messages: cytosol

10116:Mapre3
gene id: 10116:Mapre3
uniprot id: A0A8I6A6V2
uniprot id: Q5XIT1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAPRE family.
messages: Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
messages: Homodimer (By similarity). Heterodimer with MAPRE1 (By similarity). Binds monomeric and polymerized GTP-bound tubulin (By similarity). Interacts with DCTN1 (By similarity). Binds to the C-terminal domain of APC (By similarity). Interacts (via C-terminus) with CLIP1 (By similarity). Interacts with SLAIN2 and SLAIN1 (By similarity). Interacts with APC2 (By similarity). Interacts with SRCIN1 (PubMed:19146815). Interacts with AKAP9 (By similarity). Interacts with PDE4DIP; this interaction, which is PDE4DIP isoform-specific, is required for its recruitment to the Golgi apparatus (By similarity).
messages: Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (By similarity).
messages: cytoskeleton

10116:Acnat2
gene id: 10116:Acnat2
uniprot id: Q5FVR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine. Shows no conjugation activity in the presence of glycine (By similarity).
messages: Belongs to the C/M/P thioester hydrolase family.
messages: Peroxisome

10116:Dnm2
gene id: 10116:Dnm2
uniprot id: A0A0A0MY48
uniprot id: A0A8I6A1C6
uniprot id: A0A8I6ADL1
uniprot id: A6JNS3
uniprot id: P39052
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with MYOF (By similarity). Interacts with CTTN and ACTN1 (PubMed:21210813). Interacts with SHANK1, SHANK2 and NOSTRIN (By similarity). Interacts with SH3BP4 (PubMed:16325581). Interacts with SNX9 (By similarity). Interacts with SNX18 (By similarity). Interacts with SNX33 (via SH3 domain) (By similarity). Interacts with MYO1E (via SH3 domain) (PubMed:17257598). Interacts with PSTPIP1 (By similarity). Interacts with CTNND2 (By similarity). May interact with PIK3C3 (By similarity). May be a component of a complex composed of RAB5A (in GDP-bound form), DYN2 and PIK3C3 (By similarity). Interacts with BIN1 (By similarity).
messages: Localized to numerous punctate spots on the plasma membrane.
messages: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (PubMed:21210813). Plays an important role in vesicular trafficking processes, in particular endocytosis (PubMed:19995918). Involved in cytokinesis (PubMed:21195118). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity).
messages: Midbody
messages: Phosphorylation at Ser-764 by CDK1 is greatly increased upon mitotic entry. It regulates cytokinesis downstream of calcineurin, and does not affect clathrin-mediated endocytosis. Dephosphorylated by calcineurin/PP2. Phosphorylated on tyrosine residues after activation of SRC (PubMed:19995918).
messages: Postsynaptic density
messages: Sequestered to clathrin-coated pits and vesicles at the plasma membrane and the Golgi apparatus.
messages: Synapse
messages: Ubiquitously expressed. Brain expression is restricted to glial cells and fibroblasts. Highest levels in the testis.
messages: clathrin-coated pit
messages: clathrin-coated vesicle
messages: cytoskeleton
messages: phagocytic cup
messages: phagosome membrane

10116:Or4f61d
gene id: 10116:Or4f61d
uniprot id: A0A8I6AJM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ptpra
gene id: 10116:Ptpra
uniprot id: A0A8J8YBN3
uniprot id: Q66HJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

10116:Rnf135
gene id: 10116:Rnf135
uniprot id: Q5M929
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response. Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway. Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway. This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway. Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway.
messages: Homodimer. Interacts (homodimer) with RIGI (double-stranded RNA-bound oligomeric form); involved in both RIGI ubiquitination, oligomerization into filaments associated with viral RNAs and the bridging of these filaments. Interacts with UBE2D3 and UBE2N; E2 ubiquitin ligases involved in RNF135-mediated ubiquitination of RIGI and activation of the RIG-I signaling pathway. Interacts with PCBP2.
messages: Stress granule
messages: The B30.2/SPRY domain mediates the interaction with the substrate RIGI.
messages: The coiled-coil domains mediate homodimerization and the bridging of viral RNA-associated RIGI filaments.

10116:Jakmip1
gene id: 10116:Jakmip1
uniprot id: Q3SWS9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.
messages: Belongs to the JAKMIP family.
messages: Homodimer (By similarity). Interacts with JAK1 and TYK2 (By similarity). Forms a complex with GABBR1 and KIF5B/kinesin-1.
messages: Membrane
messages: Phosphorylated.
messages: Specifically expressed in brain and testis by spermatogonia, spermatocytes, spermatozoa and Sertoli cells (at protein level).
messages: cytoskeleton

10116:Hcn2
gene id: 10116:Hcn2
uniprot id: F1LRY7
uniprot id: Q9JKA9
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. cAMP binding causes a conformation change that leads to the assembly of an active tetramer and channel opening. Channel activity is modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity).
messages: Belongs to the potassium channel HCN family.
messages: By thyroid hormones in hypothyroid animals.
messages: Cell membrane
messages: Highly expressed in neonatal and adult ventricle and in brain. Highly expressed in the pyramidal layer in hippocampus, in anterior dorsal nucleus in thalamus, in the mammillary nucleus in hypothalamus, in red nucleus, in trigeminal mesencephalic, spinal and principal nuclei, in cochlear and trapezoid nuclei and in the dorsal tegemental nucleus.
messages: Homotetramer. Heterotetramer with HCN1. The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits. Forms an obligate 4:4 complex with accessory subunit PEX5L. Interacts with KCNE2 (By similarity).
messages: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current.
messages: Membrane
messages: Phosphorylation at Ser-641 by PRKG2 shifts the voltage-dependence to more negative voltages, hence counteracting the stimulatory effect of cGMP on gating.
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

10116:Fam118b
gene id: 10116:Fam118b
uniprot id: A6JYK2
uniprot id: Q4QQT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM118 family.
messages: Cajal body
messages: May play a role in Cajal bodies formation.

10116:Serpinb5
gene id: 10116:Serpinb5
uniprot id: P70564
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: Interacts with IRF6.
messages: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity (By similarity).
messages: extracellular space

10116:Ctns
gene id: 10116:Ctns
uniprot id: A6HGI6
uniprot id: D3ZG79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Membrane

10116:Or10k2
gene id: 10116:Or10k2
uniprot id: D4A8I2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Cyp2b21
gene id: 10116:Cyp2b21
uniprot id: Q9JJ02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

10116:Anapc11
gene id: 10116:Anapc11
uniprot id: A6HLF9
uniprot id: D3ZXH8
names: Similarity
messages: Belongs to the RING-box family.

10116:Vom2r58
gene id: 10116:Vom2r58
uniprot id: D3ZSN1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Or10am5
gene id: 10116:Or10am5
uniprot id: D3ZYT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Erbb3
gene id: 10116:Erbb3
uniprot id: A6KSF8
uniprot id: G3V6N1
uniprot id: Q62799
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane
messages: Monomer and homodimer. Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5, PA2G4, GRB7, MYOC and MUC1. Found in a ternary complex with NRG1 and ITGAV:ITGB3 or ITGA6:ITGB4 (By similarity).
messages: The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
messages: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.

10116:Or52e4
gene id: 10116:Or52e4
uniprot id: A6I7G8
uniprot id: D4A2W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Sdad1
gene id: 10116:Sdad1
uniprot id: Q5XIQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

10116:Or10q12
gene id: 10116:Or10q12
uniprot id: A6I0G5
uniprot id: D3ZQB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Sidt1
gene id: 10116:Sidt1
uniprot id: A0A8I6A153
uniprot id: A0A8I6ADX2
uniprot id: Q6Q3F5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded.
messages: Membrane

10116:Rap1gds1
gene id: 10116:Rap1gds1
uniprot id: A6HW43
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Mitochondrion

10116:Or6z1
gene id: 10116:Or6z1
uniprot id: A6KS68
uniprot id: D3ZHS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Lpar3
gene id: 10116:Lpar3
uniprot id: A6HWD3
uniprot id: Q8K5E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins (By similarity).

10116:Elac1
gene id: 10116:Elac1
uniprot id: A6IY18
uniprot id: D3ZB91
names: Subunit
messages: Homodimer.

10116:Mtfr2
gene id: 10116:Mtfr2
uniprot id: B0K035
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity).
messages: Mitochondrion

10116:Mrpl37
gene id: 10116:Mrpl37
uniprot id: A6JYQ1
uniprot id: Q6AXT0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL37 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

10116:RGD1561795
gene id: 10116:RGD1561795
uniprot id: D3ZF18
names: Subcellular Location Annotation
messages: cilium basal body

10116:Cnksr2
gene id: 10116:Cnksr2
uniprot id: A0A8I6A0Z8
uniprot id: A6IPN9
uniprot id: A6IPP0
uniprot id: A6IPP1
uniprot id: Q9Z1T4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CNKSR family.
messages: Cytoplasm
messages: Expressed in neurons and localized in the cell body and neurites.
messages: Interacts with RAF1, RAB2L and RAL GTPase proteins (By similarity). Interacts with DLG4 and AIP1.
messages: May function as an adapter protein or regulator of Ras signaling pathways, in synaptic junctions.
messages: Membrane
messages: Phosphorylated on tyrosine.

10116:Gadd45b
gene id: 10116:Gadd45b
uniprot id: F7FLQ8
uniprot id: Q5U3Z2
names: Similarity
messages: Belongs to the GADD45 family.

10116:Ndufs6l1
gene id: 10116:Ndufs6l1
uniprot id: A6JUY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS6 subunit family.
messages: Mitochondrion inner membrane

10116:Dap3
gene id: 10116:Dap3
uniprot id: A0A8I5ZZU0
uniprot id: A6J6B2
uniprot id: F7EZZ0
uniprot id: Q5U2T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

10116:Map1a
gene id: 10116:Map1a
uniprot id: P34926
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with guanylate kinase-like domain of DLG1, DLG2 and DLG4. Binds to CSNK1D. Interacts with TIAM2 (By similarity). MAP1 light chain LC2: Interacts with ELAVL4 (By similarity).
messages: Belongs to the MAP1 family.
messages: Brain, heart and muscle.
messages: Expressed late during neuronal development appearing when axons and dendrites begin to solidify and stabilize their morphology.
messages: LC2 is generated from MAP1A by proteolytic processing. It is free to associate with both MAP1A and MAP1B.
messages: Phosphorylated by CSNK1D.
messages: Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
messages: The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules.
messages: cytoskeleton

10116:Pgap3
gene id: 10116:Pgap3
uniprot id: A0A8I6A827
uniprot id: A6HIS2
uniprot id: M0R5R1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Pfkfb4
gene id: 10116:Pfkfb4
uniprot id: A0A8L2R9R3
uniprot id: A6I399
uniprot id: P25114
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.
messages: Synthesis and degradation of fructose 2,6-bisphosphate.
messages: Testis.
messages: The most important regulatory mechanism of these opposing activities is by phosphorylation and dephosphorylation of the enzyme.

10116:Hsd17b7
gene id: 10116:Hsd17b7
uniprot id: A0A0H2UHB1
uniprot id: A6IDN2
uniprot id: Q62904
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.
messages: Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:6946726, PubMed:9658408). Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids (PubMed:9658408) (By similarity). Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:9658408). Converts dihydrotestosterone (DHT) to an inactive form. Participates also in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase (By similarity).
messages: Binds to the short form of prolactin receptor.
messages: Endoplasmic reticulum membrane
messages: Most abundant in ovaries of pregnant animals.
messages: Phosphorylated.

10116:Chd4
gene id: 10116:Chd4
uniprot id: E9PU01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

10116:Zhx3
gene id: 10116:Zhx3
uniprot id: A0A0G2K4X5
uniprot id: A6JWZ6
uniprot id: Q80Z36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.
messages: Belongs to the ZHX family.
messages: Cytoplasm
messages: Homodimer (via homeobox domain 1). Heterodimer with ZHX1 (via homeobox domain 1). Heterodimer with ZHX2 (via homeobox domain 1). Heterodimerization with ZHX1 is a prerequisite for repressor activity. Interacts with NFYA.
messages: Nucleus
messages: Widely expressed.

10116:Tm4sf1
gene id: 10116:Tm4sf1
uniprot id: A6JVF9
uniprot id: D4ACP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

10116:Mboat2
gene id: 10116:Mboat2
uniprot id: A0A8I6A8B3
uniprot id: Q3T1J2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. May catalyze preferentially the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) and lysophosphatidic acid (LPA) and to a lesser extend lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS). Prefers oleoyl-CoA as the acyl donor (By similarity). May be involved in chondrocyte differentiation (By similarity).
messages: Belongs to the membrane-bound acyltransferase family.
messages: Endoplasmic reticulum
messages: Membrane
messages: Partially inhibited by thimerosal.

10116:Senp6
gene id: 10116:Senp6
uniprot id: A0A8I6A909
uniprot id: A6I1N0
uniprot id: A6I1N1
uniprot id: A6I1N2
uniprot id: F1LU78
names: Similarity
messages: Belongs to the peptidase C48 family.

10116:Nkap
gene id: 10116:Nkap
uniprot id: Q4V7C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter (By similarity).
messages: Belongs to the NKAP family.
messages: Component of the Notch corepressor complex. Interacts with CIR1 and HDAC3 (By similarity).
messages: Nucleus

10116:Gnpat
gene id: 10116:Gnpat
uniprot id: A6KJ21
uniprot id: Q9ES71
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the GPAT/DAPAT family.
messages: Dihydroxyacetonephosphate acyltransferase involved in plasmalogen biosynthesis.
messages: Expressed in liver (at protein level).
messages: May be part of a heterotrimeric complex composed of DAP-AT, ADAP-S and a modified form of DAP-AT.
messages: Peroxisome membrane
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

10116:Mark1
gene id: 10116:Mark1
uniprot id: O08678
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by phosphorylation on Thr-215. Inhibited by phosphorylation at Ser-219.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Highly expressed in brain and spleen and at lower levels in kidney and skeletal muscle.
messages: Interacts with MAPT/TAU.
messages: Phosphorylation at Thr-613 by PRKCZ/aPKC in polarized epithelial cells inhibits the kinase activity (By similarity). Phosphorylated at Thr-215 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-215 by TAOK1 activates the kinase activity, leading to phosphorylation and detachment of MAPT/TAU from microtubules. Phosphorylation at Ser-219 by GSK3-beta (GSK3B) inhibits the kinase activity.
messages: Serine/threonine-protein kinase (By similarity). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3) (PubMed:14517247, PubMed:14741102, PubMed:9108484).
messages: The KA1 domain mediates binding to phospholipids and targeting to membranes. Binds phosphatidic acid (PA), phosphatidylserine (PtdSer) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (By similarity).
messages: The UBA domain does not seem to bind ubiquitin and ubiquitin-like and might play a role in regulating the enzyme conformation and localization. Activation of the kinase activity following phosphorylation at Thr-208 is accompanied by a conformational change that alters the orientation of the UBA domain with respect to the catalytic domain (By similarity).
messages: cytoskeleton
messages: dendrite

10116:P2rx6
gene id: 10116:P2rx6
uniprot id: P51579
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Membrane
messages: N-glycosylated.
messages: Receptor for ATP that acts as a ligand-gated ion channel.
messages: Unlike most P2XRs, P2RX6 does not seem to form homotrimers or heterotrimers.

10116:Akap6
gene id: 10116:Akap6
uniprot id: Q9WVC7
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes (By similarity).
messages: Interacts with RII subunit of PKA, phosphatase 2B (calcineurin) and AKAP79. Interacts with SYNPO2.
messages: Nucleus membrane
messages: RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
messages: Sarcoplasmic reticulum

10116:Olr1228
gene id: 10116:Olr1228
uniprot id: A6KUE5
uniprot id: D4A209
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Vkorc1l1
gene id: 10116:Vkorc1l1
uniprot id: Q6TEK3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the VKOR family.
messages: Detected in lung, liver, testis, and at lower levels in kidney and brain.
messages: Endoplasmic reticulum membrane
messages: Inhibited by warfarin (coumadin) (PubMed:23928358). Warfarin locks VKORC1 in both redox states into the closed conformation (By similarity).
messages: Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K, and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins.

10116:Prkrip1
gene id: 10116:Prkrip1
uniprot id: A0A8I5ZUA4
uniprot id: B0BMS9
names: Similarity
messages: Belongs to the PRKRIP1 family.

10116:Stambpl1
gene id: 10116:Stambpl1
uniprot id: B0BMZ5
names: Similarity
messages: Belongs to the peptidase M67C family.

10116:Serpina1f
gene id: 10116:Serpina1f
uniprot id: A6JEP1
uniprot id: D4A4R7
names: Similarity
messages: Belongs to the serpin family.

10116:Cmpk1
gene id: 10116:Cmpk1
uniprot id: A0A8I6AP91
uniprot id: A6JZ28
uniprot id: Q4KM73
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

10116:Ethe1
gene id: 10116:Ethe1
uniprot id: A6J903
uniprot id: F7EWE8
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

10116:Ap3s2
gene id: 10116:Ap3s2
uniprot id: B0BNM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

10116:Mobp
gene id: 10116:Mobp
uniprot id: Q63327
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed predominantly in oligodendrocytes, in CNS myelin of the cerebrum and spinal cord. No expression seen in sciatic nerve.
messages: Expression in different brain regions during development is correlated with the progression of myelin formation. Isoform 5 seems to be the most abundant spliced form expressed during development. Expressed at P7 in optic nerve, at this time point, the first compact myelin is formed. At P9 abundantly expressed in the optic nerve.
messages: May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane.
messages: perinuclear region

10116:Lhx2
gene id: 10116:Lhx2
uniprot id: A6JEU2
uniprot id: D4A380
names: Subcellular Location Annotation
messages: Nucleus

10116:Slc37a1
gene id: 10116:Slc37a1
uniprot id: Q66H72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

10116:Pelo
gene id: 10116:Pelo
uniprot id: Q5XIP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy.
messages: Component of the Pelota-HBS1L complex, also named Dom34-Hbs1 complex, composed of PELO and HBS1L. Interacts with PINK1. Interacts with ABCE1. Interacts with CNOT4.
messages: Cytoplasm

10116:Pex1
gene id: 10116:Pex1
uniprot id: A6K285
uniprot id: D3ZZB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: cytosol

10116:Msx1
gene id: 10116:Msx1
uniprot id: Q9QUG0
names: Subcellular Location Annotation
messages: Nucleus

10116:Atad3a
gene id: 10116:Atad3a
uniprot id: Q3KRE0
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Can form homooligomers. Homodimer formation at the N-terminus may be regulated by ATP and is required for the interaction with the inner surface of the mitochondrial outer membrane and correct mitochondrial homeostasis. Interacts with components of the mitochondrial ribosome and with other proteins involved in mitochondrial RNA metabolism. May also interact with protein involved in lipid metabolism, including STARD9. May interact with FAM210A. Interacts with GADD45GIP1. Interacts with HSP60/HSPD1. Forms heterooligomers with ATAD3B; this interaction may affect ATAD3A activity (By similarity). Interacts with S100B in a Ca(+2)- and Zn(+2)-dependent manner; this interaction probably occurs in the cytosol prior to mitochondrial targeting. S100B could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (PubMed:20351179). Interacts with CLPB (By similarity).
messages: Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis. Involved in mitochondrial-mediated antiviral innate immunity.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: The transmembrane domain and a C-terminal adjacent region contain all information necessary for mitochondrial targeting.
messages: Up-regulated during oligodendrocyte progenitor cell differentiation.
messages: mitochondrion nucleoid

10116:Paip2
gene id: 10116:Paip2
uniprot id: A6J2Y1
uniprot id: Q6AXZ0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (By similarity).
messages: Belongs to the PAIP2 family.
messages: Cytoplasm
messages: Interacts with the second and third RRM domains and C-terminus regions of PABPC1 in a 2:1 stoichiometry.
messages: Only the PABPC1-interacting motif-1 (PAM1) interferes with the binding of PABPC1 to poly(A) RNA and translation initiation.
messages: Ubiquitinated, leading to its degradation by the proteasome.

10116:Lypla2
gene id: 10116:Lypla2
uniprot id: A6IT88
uniprot id: Q9QYL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (By similarity). Deacylates GAP43 (By similarity). Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity (By similarity). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (By similarity). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (By similarity).
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
messages: Cytoplasm

10116:Cmtr1
gene id: 10116:Cmtr1
uniprot id: A6JJV9
uniprot id: Q5U2Z5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with POLR2A (via C-terminus).
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

10116:Chst5
gene id: 10116:Chst5
uniprot id: A0A8I6GGK1
uniprot id: A6IZB3
uniprot id: A6IZB4
uniprot id: D4A9P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

10116:Defb25
gene id: 10116:Defb25
uniprot id: Q32ZG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

10116:Adh6a
gene id: 10116:Adh6a
uniprot id: A6HW30
uniprot id: D3ZT84
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

10116:Cep104
gene id: 10116:Cep104
uniprot id: D3Z8X7
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed predominantly in the brain. Also detected, although at much lower levels, in the heart and the liver. Within the brain, expressed in the cerebral cortex, hippocampus, cerebellum and brainstem.
messages: Interacts with CCP110 and CEP97. Interacts with ARMC9, TOGARAM1, CCDC66 and CSPP1.
messages: Required for ciliogenesis and for structural integrity at the ciliary tip.
messages: centriole
messages: centrosome
messages: cilium
messages: spindle pole

10116:MGC109340
gene id: 10116:MGC109340
uniprot id: A6KT32
uniprot id: Q568Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS3 family.
messages: Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3. Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3. Within the complex, interacts with SEC11A or SEC11C and SPCS1. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.
messages: Endoplasmic reticulum membrane
messages: Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity).
messages: Membrane

10116:Dhx36
gene id: 10116:Dhx36
uniprot id: D4A2Z8
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is enhanced in the presence of homomeric poly(U) RNAs, but not by double-stranded DNA (dsDNA), double-stranded RNA (dsRNA) and tRNA.
messages: Cytoplasm
messages: Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1; this complex exists in resting cells with or without dsRNA poly(I:C) ligand stimulation. Interacts (via C-terminus) with TICAM1 (via TIR domain). Interacts (via C-terminus) with DDX21; this interaction serves as bridges to TICAM1 (By similarity). Interacts with TERT; this interaction is dependent on the ability of DHX36 to bind to the G-quadruplex RNA (G4-RNA) structure present in the telomerase RNA template component (TERC). Interacts with DKC1; this interaction is dependent on the ability of DHX36 to bind to the G4-RNA structure present in TERC. Interacts with PARN; this interaction stimulates PARN to enhance uPA mRNA decay. Interacts with EXOSC3; this interaction occurs in a RNase-insensitive manner. Interacts with EXOSC10; this interaction occurs in a RNase-insensitive manner. Interacts with ILF3; this interaction occurs in a RNA-dependent manner. Interacts with ELAVL1; this interaction occurs in an RNA-dependent manner. Interacts with DDX5; this interaction occurs in a RNA-dependent manner. Interacts with DDX17; this interaction occurs in a RNA-dependent manner. Interacts with HDAC1; this interaction occurs in a RNA-dependent manner (By similarity). Interacts with HDAC3; this interaction occurs in a RNA-dependent manner (By similarity). Interacts with HDAC4 (By similarity). Interacts with AGO1. Interacts with AGO2 (By similarity). Interacts with ERCC6 (By similarity).
messages: Mitochondrion
messages: Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (By similarity). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:23651854). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA) (By similarity). Plays a role in genomic integrity. Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (By similarity). Plays a role in transcriptional regulation. Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (By similarity). Plays a role in post-transcriptional regulation. Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (By similarity). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (PubMed:23651854). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (PubMed:23651854). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability. Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression. Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively. Binds also to ARE sequences present in several mRNAs mediating exosome…
messages: Nucleus
messages: Nucleus speckle
messages: Perikaryon
messages: Stress granule
messages: The DHX36-specific motif (DSM) form folds into a DNA-binding-induced alpha-helix that together with the oligonucleotide and oligosaccharide-binding-fold-like (OB-fold-like) subdomain bind to Myc-promoter G4-DNA-containing structure in an ATP-dependent manner. Upon G4-DNA-binding, DHX36 pulls on DSM in the 3'-direction, inducing rearrangement of the RecA-like 1 and 2 and the degenerate-winged-helix (WH) regions; these rearrangements are probably responsible for the ATP-independent repetitive G4-DNA unfolding activity, one residue at a time. Upon resolving of G4-DNA into separate nucleotide strands, and ATP hydrolysis, the apoprotein of DHX36 seems incompatible with G4-DNA-binding (By similarity). The N-terminus is necessary for its recruitment to cytoplasmic stress granules (SGs) upon arsenite-induced treatment (By similarity).
messages: axon
messages: cytosol
messages: dendrite
messages: telomere

10116:H1f5
gene id: 10116:H1f5
uniprot id: D3ZBN0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Citrullination at Arg-53 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
messages: H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.
messages: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
messages: Interacts with MSX1.
messages: Nucleus
messages: The C-terminal domain is required for high-affinity binding to chromatin.

10116:Agps
gene id: 10116:Agps
uniprot id: Q9EQR2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis.
messages: Homodimer.
messages: Inhibited by divalent cation Mg(2+).
messages: Peroxisome
messages: Peroxisome membrane

10116:Mpi
gene id: 10116:Mpi
uniprot id: A6J4W0
uniprot id: Q68FX1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

10116:Nifk
gene id: 10116:Nifk
uniprot id: A0A8L2QSI2
uniprot id: A6K7V9
uniprot id: Q5RJM0
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds to the FHA domain of MKI67; this interaction is enhanced in mitosis.
messages: Chromosome
messages: Phosphorylated.
messages: nucleolus

10116:Cox6a1
gene id: 10116:Cox6a1
uniprot id: A6J1U7
uniprot id: P10818
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

10116:Cfl2
gene id: 10116:Cfl2
uniprot id: A6HBL2
uniprot id: M0RC65
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

10116:Sla
gene id: 10116:Sla
uniprot id: P59622
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins (By similarity).
messages: Cytoplasm
messages: Endosome
messages: Homodimer. Interacts with phosphorylated CBL, SYK and LAT. Homodimerization and interaction with phosphorylated CBL occurs via its C-terminal domain. Interacts with PDGFRB and EPHA2. Interacts with phosphorylated proteins ZAP70; CD3Z; VAV1 and LCP2 via its SH2 domain (By similarity).
messages: Phosphorylated.
messages: The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization (By similarity).

10116:Or1ad1
gene id: 10116:Or1ad1
uniprot id: A0A8I5ZWY2
uniprot id: A6HE38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Rtn1
gene id: 10116:Rtn1
uniprot id: A6HC34
uniprot id: Q64548
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Detected at 10 dpc in the hindbrain and at 11 dpc in the forebrain. During the next 3 embryonic days the levels of RTN1-S increases and remains stable at 13 dpc in the hindbrain and at 14 dpc in the forebrain. The levels of RTN1-B does not change as significantly during development of the hindbrain.
messages: Endoplasmic reticulum membrane
messages: Expressed predominantly in central and peripheral nervous system of newborn and adult rats. Low levels have been also detected in heart, adrenal gland and spleen. Expression of isoform RTN1-B is restricted to particular neuronal types.
messages: Golgi apparatus membrane
messages: Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.
messages: Interacts with NDRG1. Interacts with BACE1. Interacts with TMEM33.
messages: Interacts with UGCG; regulates the ceramide glucosyltransferase activity of UGCG.
messages: Membrane

10116:Laptm4b
gene id: 10116:Laptm4b
uniprot id: A6HQZ5
uniprot id: Q5U1W4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LAPTM4/LAPTM5 transporter family.
messages: Cell membrane
messages: Cell projection
messages: Endomembrane system
messages: Endosome membrane
messages: Homooligomer; upon reaching the lysosomes. Interacts with MCOLN1. Interacts with NEDD4; may play a role in the lysosomal sorting of LAPTM4B; enhances HGS association with NEDD4; mediates inhibition of EGFR degradation. Interacts with PIP5K1C; promotes SNX5 association with LAPTM4B; kinase activity of PIP5K1C is required; interaction is regulated by phosphatidylinositol 4,5-bisphosphate generated by PIP5K1C. Interacts with HGS; promotes HGS ubiquitination. Interacts with SNX5. Interacts with SLC3A2 and SLC7A5; recruits SLC3A2 and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation. Interacts with LRRC32; decreases TGFB1 production in regulatory T cells. Interacts with BECN1; competes with EGFR for LAPTM4B binding; regulates EGFR activity. Interacts with EGFR; positively correlates with EGFR activation.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways.
messages: Ubiquitinated by NEDD4.
messages: Undergoes proteolytic cleavage following delivery to the lysosomes.
messages: multivesicular body lumen
messages: multivesicular body membrane

10116:Trpv2
gene id: 10116:Trpv2
uniprot id: A0A0G2JSH6
uniprot id: Q9WUD2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.
messages: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation.
messages: Melanosome
messages: Membrane
messages: N-glycosylated.
messages: Phosphorylated by PKA.
messages: Ubiquitously expressed. Expressed in dorsal root ganglia, trigeminal ganglia, spinal cord (Lissauer's tract, dorsal horn and dorsal columns) (at protein level).

10116:Mpdz
gene id: 10116:Mpdz
uniprot id: A0A0G2K2Y8
uniprot id: A0A8L2QPJ0
uniprot id: A6J832
uniprot id: O55164
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in all cerebral cortical layers, especially the piriform cortex, the pyramidal cells of the CA1-CA3 subfields of the hippocampus, as well as the granular layer of the dentate gyrus. Detected in the internal granular layer and the mitral cell layer of the olfactory bulb; in the medial habenular nucleus; and in amygdaloid, thalamic, hypothalamic, and pontine nuclei. In the cerebellum, found at high levels in the granular layer. Detected in the lateral ventricle. Expression overlaps with 5-HT2C receptor expression in all regions of the brain including the choroid plexus, where 5-HT2C receptors are highly enriched.
messages: Apical cell membrane
messages: Endomembrane system
messages: Interacts with F11R/JAM, CLDN1, NG2, CXADR, CRB1, MPP4 and PALS1, HTR2A, HTR2B, PLEKHA1/TAPP1 and PLEKHA2/TAPP2. Interacts with CXADR (By similarity). Interacts with HTR2C, CLDN5, DLG4, GRIN1, SYNGAP1, CAMK2A and CAMK2B. Interacts with FAT4 (via cytoplasmic domain) (By similarity). Interacts with DLL1 (By similarity).
messages: Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:15312654). Promotes clustering of HT2RC at the cell surface (PubMed:11150294).
messages: Postsynaptic density
messages: Sequestered into cytoplasmic, detergent-resistant bodies upon Ad9 E4-ORF1 oncoprotein expression. Targeted to degradation upon HPV-18 E6 oncoprotein expression.
messages: Synapse
messages: The PDZ domain 1 binds NG2. The PDZ domain 2 mainly binds CAMK2A and CAMK2B. The PDZ domain 9 binds F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT. The PDZ domains 10 and 13 bind PLEKHA1 and PLEKHA2. The PDZ domain 13 binds CXADR and SYNGAP1 (By similarity). The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 10 binds the C-terminal PDZ-binding motif of HTR2C.
messages: dendrite
messages: synaptosome
messages: tight junction

10116:Phrf1
gene id: 10116:Phrf1
uniprot id: Q63625
names: Subunit
messages: Interacts with POLR2A (via the C-terminal domain).

10116:Gtf3a
gene id: 10116:Gtf3a
uniprot id: Q8VHT8
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (By similarity). Also binds the transcribed 5S RNA's (By similarity).
messages: It is uncertain whether Met-1 is the initiator. Based on the lack of an in-frame AUG codon, mammalian TFIIIA may be translated from this non-AUG initiation site, which has a good Kozak context and which is well conserved among mammals.
messages: Nucleus

10116:Tnk2
gene id: 10116:Tnk2
uniprot id: A0A0G2K2Q7
uniprot id: Q5U2X5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylation regulates kinase activity. Phosphorylation on Tyr-518 is required for interaction with SRC and is observed during association with clathrin-coated pits (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Endosome
messages: Homodimer. Interacts with CDC42. Interacts with CSPG4 (activated). Interacts with MERTK (activated); stimulates autophosphorylation. May interact (phosphorylated) with HSP90AB1; maintains kinase activity. Interacts with NPHP1. Interacts with SNX9 (via SH3 domain). Interacts with SRC (via SH2 and SH3 domain). Interacts with EGFR, and this interaction is dependent on EGF stimulation and kinase activity of EGFR. Interacts (via kinase domain) with AKT1. Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with BCAR1/p130cas via SH3 domains. Forms complexes with GRB2 and numerous receptor tyrosine kinases (RTK) including LTK, AXL or PDGFRL, in which GRB2 promotes RTK recruitment by TNK2. Interacts with NEDD4 (via WW3 domain). NEDD4L and EGF promote association with NEDD4 (By similarity).
messages: Membrane
messages: Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363', thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR (By similarity).
messages: Nucleus
messages: Polyubiquitinated by NEDD4 and NEDD4L. Degradation can be induced by EGF and is lysosome-dependent (By similarity).
messages: The EBD (EGFR-binding domain) domain is necessary for interaction with EGFR.
messages: The SAM-like domain is necessary for NEDD4-mediated ubiquitination. Promotes membrane localization and dimerization to allow for autophosphorylation (By similarity).
messages: The UBA domain binds both poly- and mono-ubiquitin.
messages: adherens junction
messages: clathrin-coated pit
messages: clathrin-coated vesicle
messages: cytosol

10116:Arfgap1
gene id: 10116:Arfgap1
uniprot id: Q62848
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine.
messages: Golgi apparatus
messages: Interacts with ARF1. Interacts with the COPI coat proteins, KDELR1 and TMED2. It is probably a component of the COPI coat protein complex. The interaction with TMED2 inhibits the GAP activity.
messages: The region downstream of Arf-GAP domain is essential to GAP activity in vivo. This region may be required for its targeting to Golgi membranes.
messages: Widely expressed. Highly expressed in brain and liver.

10116:Daxx
gene id: 10116:Daxx
uniprot id: A0A8I6GLP1
uniprot id: A1A5M7
uniprot id: Q6MGC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAXX family.
messages: Cytoplasm
messages: PML body
messages: centromere
messages: nucleolus
messages: nucleoplasm

10116:Emc6
gene id: 10116:Emc6
uniprot id: A6HGI2
uniprot id: D4ABX9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:RGD1559459
gene id: 10116:RGD1559459
uniprot id: F1LTB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

10116:Neto2
gene id: 10116:Neto2
uniprot id: C6K2K4
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission.
messages: Brain (at protein level).
messages: Interacts with GRIK2 and GRIK3, but neither with AMPA-nor with NMDA-sensitive glutamate receptors.
messages: Membrane
messages: N-glycosylated.

10116:Rps18
gene id: 10116:Rps18
uniprot id: A6JJH6
uniprot id: P62271
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the small ribosomal subunit.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

10116:Tfb2m
gene id: 10116:Tfb2m
uniprot id: A0A8I5ZY51
uniprot id: Q5U2T7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
messages: Homodimer. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT. In this complex TFAM recruits POLRMT to the promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Stimulates transcription independently of the methyltransferase activity.

10116:Ffar3
gene id: 10116:Ffar3
uniprot id: B2GV46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in the sympathetic nervous system.
messages: G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases (PubMed:24305827). Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis (PubMed:24412651). May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Final…

10116:Lat
gene id: 10116:Lat
uniprot id: O70601
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: 'Lys-63'-linked ubiquitinated by TRAF6.
messages: Cell membrane
messages: Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and blocks target cell-induced activation of PLC, maybe by inducing the dephosphorylation of LAT.
messages: Expressed in NK cells. Present in lymph node, spleen and thymus (at protein level).
messages: Palmitoylation of Cys-27 and Cys-30 is required for raft targeting and efficient phosphorylation.
messages: Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ (By similarity).
messages: Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes.
messages: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules (By similarity).
messages: When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK. Interacts with FCGR1A. Interacts with GRB2, PLCG1 and THEMIS upon TCR activation in thymocytes (By similarity). Interacts with THEMIS2 (By similarity).

10116:Stat2
gene id: 10116:Stat2
uniprot id: Q5XI26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

10116:Senp18
gene id: 10116:Senp18
uniprot id: Q6IE22
names: Similarity
messages: Belongs to the peptidase C48 family.

10116:Sprn
gene id: 10116:Sprn
uniprot id: A6HXH7
uniprot id: Q5BIV7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Almost exclusively expressed in brain, with weak expression in lung and stomach.
messages: Belongs to the SPRN family.
messages: Cell membrane
messages: N-glycosylated.
messages: Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).
messages: Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP.

10116:Smcp
gene id: 10116:Smcp
uniprot id: Q64298
names: Caution
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in postmeiotic cells.
messages: Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity).
messages: Mitochondrion membrane
messages: Testis. Selectively expressed in the spermatids of seminiferous tubules and in flagella of epididymal sperm.
messages: Was originally thought to be a selenoprotein and was known as sperm mitochondrial capsule selenoprotein.

10116:Slc4a2
gene id: 10116:Slc4a2
uniprot id: A0A8I5Y5U0
uniprot id: A6K551
uniprot id: P23347
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Expressed in the parotid and submandibular glands (at protein level) (PubMed:10600827). Expressed in the gastric mucosa (at protein level) (PubMed:8141271). Expressed in the choroid plexus epithelium (at protein level) (PubMed:2371270). Expressed in the liver and gallbladder (PubMed:22310983).
messages: Inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS).
messages: Membrane
messages: Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:2371270). Plays an important role in osteoclast differentiation and function (By similarity). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity).

10116:Pole3
gene id: 10116:Pole3
uniprot id: Q642A5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (By similarity). Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (By similarity).
messages: Component of the DNA polymerase epsilon complex consisting of four subunits: the catalytic subunit POLE and the accessory subunits POLE2, POLE3 and POLE4. Interaction with POLE4 is a prerequisite for further binding with POLE and POLE2. Heterodimer with CHRAC1; binds to DNA (By similarity). Component of the CHRAC ISWI chromatin remodeling complex at least composed of SMARCA5/SNF2H, BAZ1A/ACF1, CHRAC1 and POLE3; the complex preferentially binds DNA through the CHRAC1-POLE3 heterodimer and possesses ATP-dependent nucleosome-remodeling activity (By similarity). Within the complex, the heterodimer with CHRAC1 interacts with SMARCA5/SNF2H; the interaction is direct and enhances nucleosome sliding activity by the SMARCA5/SNF2H and BAZ1A/ACF1 interaction (By similarity). Within the complex, the heterodimer with CHRAC1 interacts with BAZ1A/ACF1; the interactions are direct (By similarity).
messages: Nucleus

10116:Ciao2b
gene id: 10116:Ciao2b
uniprot id: D3Z8Q7
names: Similarity
messages: Belongs to the MIP18 family.

10116:Htra2
gene id: 10116:Htra2
uniprot id: B0BNB9
uniprot id: F7FLZ6
names: Similarity
messages: Belongs to the peptidase S1C family.

10116:Higd1a
gene id: 10116:Higd1a
uniprot id: A6I463
uniprot id: Q8VH49
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Associates with cytochrome c oxidase (COX, complex IV); proposed complex component. Also associates with respiratory chain supercomplexes (By similarity).
messages: Expressed in brain and spinal cord.
messages: Expression is increased between P1 and P15 in the spinal cord and a differential spatial pattern. In the P1 spinal cord there is a preferential expression in regions of dorsal laminae II and III and laminae IX ventrally; while in P8, the distribution is more widespread and overall expression is increased.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity).

10116:Ccna2
gene id: 10116:Ccna2
uniprot id: A0A0G2JVY9
uniprot id: A6IHY4
uniprot id: G3V802
uniprot id: Q91ZX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family.
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Nucleus

10116:Rrm2b
gene id: 10116:Rrm2b
uniprot id: A6HR51
uniprot id: D4ADQ1
names: Cofactor
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.

10116:Or1o2
gene id: 10116:Or1o2
uniprot id: Q6MFX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Adamts4
gene id: 10116:Adamts4
uniprot id: Q9ESP7
names: Cofactor
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Brain specific.
messages: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
messages: Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
messages: Interacts with SRPX2.
messages: The precursor is cleaved by a furin endopeptidase.
messages: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
messages: extracellular matrix

10116:Rgs3
gene id: 10116:Rgs3
uniprot id: A0A0G2K1B5
uniprot id: A0A8I5ZT37
uniprot id: P49797
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds EFNB1 and EFNB2. Binds the GNB1-GNG2 heterodimer (By similarity). Binds ESR1.
messages: Cytoplasm
messages: Detected in kidney, uterus, ovary, heart, brain, spleen, lung and testis.
messages: Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.
messages: ISGylated.
messages: Membrane
messages: Nucleus
messages: Phosphorylated by cyclic GMP-dependent protein kinase.

10116:Psma8
gene id: 10116:Psma8
uniprot id: A6KLT8
uniprot id: F1M6I7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

10116:Lpp
gene id: 10116:Lpp
uniprot id: Q5XI07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zyxin/ajuba family.
messages: Cell junction
messages: Cytoplasm
messages: Interacts with PDZ domains of SCRIB, with VASP and with ACTN1/alpha-actinin.
messages: May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus (By similarity).
messages: Nucleus

10116:Galnt5
gene id: 10116:Galnt5
uniprot id: A6JF52
uniprot id: O88422
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2, Muc1b, rMuc-2 or mG-Muc substrates.
messages: Golgi apparatus membrane
messages: Interacts with EXT2. Does not interact with EXT1, EXTL1 or EXTL3 (By similarity).
messages: Membrane
messages: Predominantly expressed in sublingual gland. Expressed at lower level in stomach and small intestine. Weakly or not expressed in submandibular gland, parotid gland, kidney, liver, heart, brain, spleen, lung, skeletal muscle, testis, ovary, cervix and uterus.
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

10116:Atp5mf
gene id: 10116:Atp5mf
uniprot id: D3ZAF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase F chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion
messages: Mitochondrion inner membrane

10116:Krtap13
gene id: 10116:Krtap13
uniprot id: A6JL98
uniprot id: D4AD54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

10116:Hoxb3
gene id: 10116:Hoxb3
uniprot id: A6HIE8
uniprot id: F7FL39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

10116:Myo7a
gene id: 10116:Myo7a
uniprot id: A0A8J8XYU9
uniprot id: Q8CJE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: cytoskeleton

10116:Prox2
gene id: 10116:Prox2
uniprot id: D3ZHL7
names: Subcellular Location Annotation
messages: Nucleus

10116:Zg16
gene id: 10116:Zg16
uniprot id: Q8CJD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the jacalin lectin family.
messages: Expressed in pancreas, colon, duodenum, and much less in stomach.
messages: Golgi apparatus lumen
messages: May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.
messages: Zymogen granule lumen
messages: extracellular matrix

10116:Gh1
gene id: 10116:Gh1
uniprot id: A0A0M6L0P3
uniprot id: B2RYR2
uniprot id: P01244
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
messages: Secreted

10116:Defb43
gene id: 10116:Defb43
uniprot id: Q32ZF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has bactericidal activity.
messages: Secreted

10116:Radx
gene id: 10116:Radx
uniprot id: B2GV47
names: Function
names: Subcellular Location Annotation
messages: Chromosome
messages: Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks.

10116:Mnda
gene id: 10116:Mnda
uniprot id: Q5U2R8
names: Similarity
messages: Belongs to the HIN-200 family.

10116:Defb4
gene id: 10116:Defb4
uniprot id: A6IWA3
uniprot id: O88514
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells.
messages: Highly expressed in lung.
messages: Secreted

10116:Unc13c
gene id: 10116:Unc13c
uniprot id: A0A0G2K3J2
uniprot id: Q62770
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the unc-13 family.
messages: Cytoplasm
messages: Exclusively expressed in brain, predominantly in the cerebellum.
messages: First detected at birth, after which expression level is steadily increasing until it reaches a plateau at P15.
messages: Interacts with STX1A and/or STX1B1, VAMP2 and SNAP25.
messages: May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses (By similarity).
messages: Membrane
messages: Presynaptic cell membrane
messages: The C2 domains are not involved in calcium-dependent phospholipid binding.

10116:Car2
gene id: 10116:Car2
uniprot id: A6IH09
uniprot id: P27139
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide (By similarity). Can also hydrate cyanamide to urea (By similarity). Involved in the regulation of fluid secretion into the anterior chamber of the eye (By similarity). Essential for bone resorption and osteoclast differentiation (PubMed:9665810). Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption (By similarity). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Inhibited by acetazolamide.
messages: Interacts with SLC4A4 and SLC26A6. Interaction with SLC4A7 regulates SLC4A7 transporter activity (By similarity).
messages: Reversible hydration of carbon dioxide.

10116:Vnn1
gene id: 10116:Vnn1
uniprot id: F7FPD6
uniprot id: Q4KLZ0
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

10116:Adgrg2
gene id: 10116:Adgrg2
uniprot id: A6IPL1
uniprot id: A6IPL3
uniprot id: Q8CJ11
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Epididymis-specific expression (at protein level). Associated with apical membranes of efferent ductule and proximal epididymal duct epithelia (PubMed:12420295).
messages: Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.
messages: Highly glycosylated.
messages: Membrane
messages: Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis.
messages: Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.

10116:Plppr4
gene id: 10116:Plppr4
uniprot id: A6HVB7
uniprot id: G3V864
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

10116:Ank3
gene id: 10116:Ank3
uniprot id: O70511
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expressed at highest levels in brain and testis, followed by skin, kidney, liver and spleen. Isoforms 2, 3, 4, 5, 6 and 7 may be specifically expressed in muscle tissues, including heart and skeletal muscle (extensor digitorum longus) (at protein level) (PubMed:11796721).
messages: Lysosome
messages: May be a constituent of a NFASC/NRCAM/ankyrin G complex. Interacts with RHBG. Directly interacts with DMD and betaDAG1; this interaction does not interfere with DMD-binding and is required for DMD and betaDAG1 retention at costameres. Interacts (via N-terminal ANK repeats) with SCHIP1 isoform 7 (via C-terminus); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs) (By similarity). Interacts with PLEC and FLNC (PubMed:21223964). Isoform 7 interacts with PLEC and FLNC through its muscle-specific C-terminal sequence. Interacts with KCNA1; this inhibits channel activity (By similarity). Interacts (via ANK repeats) with IQCJ-SCHIP1; required for IQCJ-SCHIP1 localization at axon initial segments (AIS) and nodes of Ranvier (By similarity). Interacts with SCHIP1 (By similarity). Interacts with SCN5A (By similarity).
messages: Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (By similarity).
messages: Postsynaptic cell membrane
messages: T-tubule
messages: The 76 amino-acid long sequence from Asp-1060 to Val-1135 is encoded by a muscle-specific exon.
messages: The 76 amino-acid long sequence from Asp-1077 to Val-1152 is encoded by a muscle-specific exon.
messages: The 76 amino-acid long sequence from Asp-1710 to Val-1785 is encoded by a muscle-specific exon.
messages: The 76 amino-acid long sequence from Asp-1888 to Val-1963 is encoded by a muscle-specific exon.
messages: The 76 amino-acid long sequence from Asp-864 to Val-939 is encoded by a muscle-specific exon.
messages: The 76 amino-acid long sequence from Asp-881 to Val-956 is encoded by a muscle-specific exon.
messages: axon
messages: cytoskeleton
messages: sarcolemma

10116:Pus7l
gene id: 10116:Pus7l
uniprot id: D4ABN2
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

10116:Tmem120a
gene id: 10116:Tmem120a
uniprot id: A6J0B8
uniprot id: Q5HZE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM120 family.
messages: Cell membrane
messages: Homooligomer and heterooligomer with TMEM120B.
messages: Ion channel involved in sensing mechanical pain. Contributes to mechanosensitive currents in nocireceptors and detecting mechanical pain stimuli. May also be required for efficient adipogenesis.
messages: Membrane
messages: Nucleus inner membrane

10116:Camk2g
gene id: 10116:Camk2g
uniprot id: A0A8I5Y738
uniprot id: A0A8I5ZV59
uniprot id: A0A8I6A5E2
uniprot id: A0A8I6AD45
uniprot id: P11730
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
messages: Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state (By similarity).
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
messages: By cocaine in cardiomyocytes.
messages: CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other (By similarity).
messages: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (By similarity). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (By similarity). In the central nervous system, it is involved in the regulation of neurite formation and arborization. It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity).
messages: Sarcoplasmic reticulum membrane
messages: The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.

10116:Ldaf1
gene id: 10116:Ldaf1
uniprot id: A0A8I6A4Z9
uniprot id: A6I8P8
uniprot id: Q6UK00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with BSCL2/seipin to form an oligomeric complex.
messages: Lipid droplet
messages: Membrane
messages: Plays an important role in the formation of lipid droplets (LD) which are storage organelles at the center of lipid and energy homeostasis (By similarity). In association with BSCL2/seipin, defines the sites of LD formation in the endoplasmic reticulum (By similarity).

10116:Rnf170
gene id: 10116:Rnf170
uniprot id: A0A8I5ZKY1
uniprot id: A6IVZ0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:Cox7a2l
gene id: 10116:Cox7a2l
uniprot id: A6H9M6
uniprot id: B2RYT5
uniprot id: D3ZYX8
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

10116:Ncoa3
gene id: 10116:Ncoa3
uniprot id: A6JXG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

10116:Borcs6
gene id: 10116:Borcs6
uniprot id: Q66H43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.
messages: Belongs to the BORCS6 family.
messages: Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN.
messages: Lysosome membrane

10116:Chd1
gene id: 10116:Chd1
uniprot id: A6KB55
uniprot id: D4AAG9
names: Subcellular Location Annotation
messages: Nucleus

10116:Nat9
gene id: 10116:Nat9
uniprot id: A0A8I5ZU60
uniprot id: A6HKK9
names: Similarity
messages: Belongs to the acetyltransferase family. GNAT subfamily.

10116:Klhl41
gene id: 10116:Klhl41
uniprot id: Q9ER30
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Interacts with NRAP. Part of a complex that contains CUL3, RBX1 and KLHL41. Interacts with LASP1.
messages: Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells.
messages: M line
messages: Primarily expressed in skeletal muscle. Also found in heart and lung.
messages: Sarcoplasmic reticulum membrane
messages: Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination.
messages: cytoskeleton
messages: pseudopodium
messages: ruffle

10116:Olr1125
gene id: 10116:Olr1125
uniprot id: A6JNG0
uniprot id: D4A8Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ezh1
gene id: 10116:Ezh1
uniprot id: A6HJ95
names: Subcellular Location Annotation
messages: Nucleus

10116:Mmadhc
gene id: 10116:Mmadhc
uniprot id: Q6AYQ6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer with MMACHC. Forms a multiprotein complex with MMACHC, MTR and MTRR.
messages: Involved in cobalamin metabolism and trafficking. Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl). Promotes oxidation of cob(II)alamin bound to MMACHC. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Mitochondrion

10116:Tmem11
gene id: 10116:Tmem11
uniprot id: A0A0G2JUS7
uniprot id: B0BN86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with IMMT/MIC60.
messages: Belongs to the TMEM11 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Plays a role in mitochondrial morphogenesis.

10116:Tmem8b
gene id: 10116:Tmem8b
uniprot id: D4AD81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

10116:Neu3
gene id: 10116:Neu3
uniprot id: A6I6K4
uniprot id: Q99PW5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 33 family.
messages: Cell membrane
messages: Early endosome membrane
messages: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes.
messages: Expressed in brain, cardiac muscle and weakly in liver.
messages: Interacts with CAV1; this interaction enhances NEU3 sialidase activity within caveola. Interacts with EGFR; this interaction mediates desialylation of EGFR enhancing downstream signaling.
messages: Lysosome membrane
messages: Palmitoylated; may regulate intracellular trafficking and anchorage to plasma membrane and endomembranes.
messages: Recycling endosome membrane
messages: caveola

10116:Ifitm3
gene id: 10116:Ifitm3
uniprot id: P26376
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CD225/Dispanin family.
messages: By interferon beta.
messages: Cell membrane
messages: Early endosome membrane
messages: IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.
messages: Interacts with ATP6V0B (By similarity). Interacts with CD81 (By similarity). Interacts with SPP1; the interaction reduces OPN expression (By similarity). Interacts with BRI3 (By similarity).
messages: Late endosome membrane
messages: Lysosome membrane
messages: Phosphorylation at Tyr-20 is required for endosomal and lysosomal location.
messages: Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Ubiquitination negatively regulates antiviral activity. Lys-24 is the most prevalent ubiquitination site.
messages: perinuclear region

10116:Ca5b
gene id: 10116:Ca5b
uniprot id: A6K2L9
uniprot id: Q66HG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Mitochondrion
messages: Reversible hydration of carbon dioxide.

10116:Macir
gene id: 10116:Macir
uniprot id: A6JR86
uniprot id: D3ZPS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

10116:Fcrl2
gene id: 10116:Fcrl2
uniprot id: A6J602
uniprot id: F1M652
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Zfp446
gene id: 10116:Zfp446
uniprot id: A0A8I5ZPP3
uniprot id: A6KQM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

10116:Sh3gl3
gene id: 10116:Sh3gl3
uniprot id: A0A8I6APE5
uniprot id: A0A9K3Y7M5
uniprot id: O35180
uniprot id: Q9JKT0
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.
messages: Belongs to the endophilin family.
messages: Cells overexpressing Sh3gl3 show inhibition of transferrin uptake. Olfactory epithelium-derived cells overexpressing SH3GL3, DRD2 and GRK2 show accelerated differentiation upon addition of apomorphine due to reduced agonist-induced endocytosis of DRD2.
messages: Cytoplasm
messages: Early endosome membrane
messages: Expressed at high level in testis and at lower level in brain and liver.
messages: Implicated in endocytosis. May recruit other proteins to membranes with high curvature.
messages: Interacts with SGIP1 and DYDC1 (By similarity). Interacts with FASLG. Interacts with ATXN2. Interacts with BIN2 (By similarity). Interacts with ARC, DNM1 and SYNJ1.
messages: Membrane

10116:Smim8
gene id: 10116:Smim8
uniprot id: A6IIN4
uniprot id: G3V8Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

10116:Tmem151a
gene id: 10116:Tmem151a
uniprot id: B5DF40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

10116:Trpv5
gene id: 10116:Trpv5
uniprot id: Q9JIP0
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by WNK3.
messages: Apical cell membrane
messages: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily.
messages: Cell membrane
messages: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:10875938). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (By similarity). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).
messages: Detected in kidney (at protein level). Detected in kidney.
messages: Glycosylated.
messages: Homotetramer and probably heterotetramer with TRPV6. Interacts with TRPV6 (By similarity). Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation (By similarity).

10116:Aipl1
gene id: 10116:Aipl1
uniprot id: Q9JLG9
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Highly expressed in retina.
messages: Interacts with NUB1.
messages: May be important in protein trafficking and/or protein folding and stabilization.
messages: Nucleus

10116:Kank2
gene id: 10116:Kank2
uniprot id: D3ZD05
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed by podocytes in kidney glomeruli (at protein level).
messages: Interacts (non-phosphorylated form) with NCOA1; NCOA2 AND NCOA3 (By similarity). Interacts with AIFM1 (By similarity). Interacts with ARHGDIA; the interaction is direct and may regulate the interaction of ARHGDIA with RHOA, RAC1 and CDC42 (PubMed:25961457). Interacts (via ANK repeats 1-5) with KIF21A (By similarity).
messages: Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (By similarity). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (By similarity). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (By similarity). Involved in the negative control of vitamin D receptor signaling pathway (By similarity). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (By similarity). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (By similarity). Through the Rho signaling pathway may also regulate cell proliferation (By similarity).
messages: Mitochondrion
messages: Phosphorylated by casein kinase II upon estrogen stimulation (By similarity). Phosphorylation induces the release by KANK2 of NCOA1 and its translocation to the nucleus where NCOA1 can activate gene transcription (By similarity).

10116:Glod4
gene id: 10116:Glod4
uniprot id: A6HGV1
uniprot id: Q5I0D1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyoxalase I family.
messages: Interacts with NUDT9.
messages: Mitochondrion

10116:Mybpc1
gene id: 10116:Mybpc1
uniprot id: Q63518
names: Function
names: Similarity
names: Subunit
messages: Belongs to the immunoglobulin superfamily. MyBP family.
messages: Interacts with USP25 (isoform USP25m only); the interaction prevents proteasomal degradation of MYBPC1.
messages: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin. In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role.

10116:Dmac2l
gene id: 10116:Dmac2l
uniprot id: Q5XIM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP synthase subunit s family.
messages: Homotetramer. Associates with ATP synthase.
messages: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.
messages: Mitochondrion
messages: Mitochondrion inner membrane

10116:Trim36
gene id: 10116:Trim36
uniprot id: A0A0G2JW11
uniprot id: A6IWV0
uniprot id: F1LY63
names: Subcellular Location Annotation
messages: cytoskeleton

10116:Acot4
gene id: 10116:Acot4
uniprot id: A6JDS7
uniprot id: D3ZIQ1
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

10116:Oaz3
gene id: 10116:Oaz3
uniprot id: A1BPI0
names: Function
names: Miscellaneous
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ODC antizyme family.
messages: Cytoplasm
messages: Does not possess antizyme activity. Modulates PPP1CB activity through its interaction with PPP1R16A.
messages: Interacts with ODC1 and thereby sterically blocks ODC homodimerization (By similarity). Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1 (By similarity). Interacts with GGN (By similarity). Isoform 2 interacts with PPP1R16A; Modulates PPP1CB activity (PubMed:21712390).
messages: Nucleus
messages: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity).
messages: Produced by alternative splicing. This form is not the result of ribosomal frameshift.
messages: Produced by ribosomal frameshifting occurring between the codons for Ser-86 and Glu-87. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.
messages: PubMed:17040916 reports an event of trans-splicing that creates a hybrid 14-kDa protein whose N-terminal 105 amino acids are encoded by the rat Oaz3 gene, located on chromosome 2 and its C-terminal 33 amino acids by a novel gene located on chromosome 4. The nuclear pre-mRNA of Oaz3 gene has 5 adenosine residues whereas the nuclear trans-spliced RNA has 6 adenosine residues suggesting that an unknown nuclear process adds 1 adenosine affecting the reading frame. Moreover the hybrid 14-kDa protein is the result of ribosomal frameshift. The hybrid 14-KDa protein is present in the outer dense fibers and the fibrous sheath and expressed in lung.
messages: Testis-specific. Isoform 2 is expressed in outer dense fibers, fibrous sheath and the connecting piece of sperm (PubMed:21712390).
messages: Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.
messages: flagellum

10116:Myo5c
gene id: 10116:Myo5c
uniprot id: F1M111
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

10116:Atraid
gene id: 10116:Atraid
uniprot id: B2RYU3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Lck
gene id: 10116:Lck
uniprot id: A0A0H2UHH7
uniprot id: Q01621
names: Activity Regulation
names: Disease Annotation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on Tyr-394, increasing enzymatic activity, this site is dephosphorylated by PTN22. Phosphorylated on Tyr-505 by CSK, decreasing activity. Dephosphorylated by PTPRC/CD45. Dephosphorylation at Tyr-394 by PTPN2 negatively regulates T-cells differentiation (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: Binds to the cytoplasmic domain of cell surface receptors, such as AXL, CD2, CD4, CD5, CD8, CD44, CD45 and CD122. Also binds to effector molecules, such as PI4K, VAV1, RASA1, FYB1 and to other protein kinases including CDK1, RAF1, ZAP70 and SYK. Binds to phosphatidylinositol 3'-kinase (PI3K) from T-lymphocytes through its SH3 domain and to the tyrosine phosphorylated form of KHDRBS1/p70 through its SH2 domain. Interacts with SQSTM1. Interacts with phosphorylated LIME1. Interacts with CBLB and PTPRH. Interacts with RUNX3. Forms a signaling complex with EPHA1, PTK2B and PI3-KINASE; upon activation by EFNA1 which may regulate T-lymphocytes migration. Associates with ZAP70 and RHOH; these interactions allow LCK-mediated RHOH and CD3 subunit phosphorylations in presence of a functional ZAP70. Interacts with CEACAM1 (via cytoplasmic domain); mediates CEACAM1 phosphorylation resulting in PTPN6 recruitment that dephosphorylates TCR stimulation-induced CD247 and ZAP70. Interacts with FYB2. Interacts with CD160. Interacts with CD48.
messages: Cell membrane
messages: Membrane
messages: Myristoylation is required prior to palmitoylation.
messages: Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP (By similarity). Interacts with UNC119; this interaction plays a crucial role in activation of LCK (By similarity).
messages: Palmitoylation regulates association with the plasma membrane and could be mediated by ZDHHC2.
messages: Proviral insertion upstream of the Lck gene causes overexpression, leading to the development of thymic lymphoma.
messages: The relative activities of the inhibitory tyrosine-protein kinase CSK and the activating tyrosine-protein phosphatase PTPRC/CD45 determine the level of LCK activity. These interactions allow rapid and efficient activation of LCK in response to TCR stimulation (By similarity).
messages: cytosol

10116:Or13c3f
gene id: 10116:Or13c3f
uniprot id: D3ZDJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Map10
gene id: 10116:Map10
uniprot id: D3ZAP3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts (via middle region) with microtubules.
messages: Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis.
messages: Midbody
messages: centrosome
messages: cytoskeleton
messages: spindle pole

10116:Cds1
gene id: 10116:Cds1
uniprot id: A6K5W7
uniprot id: O35052
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by GTP. Inhibited by CDP-diacylglycerol and by phosphatidylglycerol 4,5-bisphosphate (PPI2).
messages: Belongs to the CDS family.
messages: Brain, retina and testis. Found in cerebellar Purkinje cells, pineal body, inner segment of photoreceptor cells and postmitotic spermatocytes and spermatids.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:9083091, PubMed:9345289, PubMed:29253589, PubMed:30862571). Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs (By similarity). Plays an important role in regulatinng the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (By similarity). Positively regulates the differentiation and development of adipocytes (By similarity).
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Endoplasmic reticulum membrane
messages: Homodimer (PubMed:29253589). Interacts with FOS; this interaction may enhance catalytic activity (By similarity).
messages: Membrane

10116:Hpx
gene id: 10116:Hpx
uniprot id: P20059
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the hemopexin family.
messages: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
messages: Expressed by the liver and secreted in plasma.
messages: Secreted
messages: The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear (By similarity).

10116:Or8k24
gene id: 10116:Or8k24
uniprot id: D4A4M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Vom2r61
gene id: 10116:Vom2r61
uniprot id: A0A8I6AIC5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Lipt2
gene id: 10116:Lipt2
uniprot id: A6I6L6
uniprot id: D3Z9Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Mitochondrion

10116:Mrpl3
gene id: 10116:Mrpl3
uniprot id: A6I2M4
uniprot id: G3V7P3
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

10116:Dcp1a
gene id: 10116:Dcp1a
uniprot id: D4AE80
names: Similarity
messages: Belongs to the DCP1 family.

10116:Palm
gene id: 10116:Palm
uniprot id: Q920Q0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apicolateral cell membrane
messages: Basolateral cell membrane
messages: Belongs to the paralemmin family.
messages: Cell membrane
messages: Expressed in neurons cells of neuropil-rich areas of the brain, in the Purkinje cells of the cerebellum, in cells of the cerebral cortex, hippocampus, brainstem nuclei and glial processes and sheaths. Expressed in the medulla of the adrenal chromaffin cells and renal duct cells (at protein level).
messages: Expressed in pyramidal neurons of the hippocampus at 18 dpc.
messages: Interacts with dopamine receptor DRD3.
messages: Involved in plasma membrane dynamics and cell process formation. Necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner (By similarity).
messages: axon
messages: dendrite
messages: dendritic spine
messages: filopodium membrane

10116:Gabpa
gene id: 10116:Gabpa
uniprot id: A6JL60
uniprot id: D4ACQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

10116:Cd6
gene id: 10116:Cd6
uniprot id: A6I060
uniprot id: G3V8U0
uniprot id: Q5FVU4
uniprot id: Q812A4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Pcna
gene id: 10116:Pcna
uniprot id: A6HQF8
uniprot id: P04961
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by CREBBP and p300/EP300; preferentially acetylated by CREBBP on Lys-80, Lys-13 and Lys-14 and on Lys-77 by p300/EP300 upon loading on chromatin in response to UV irradiation. Lysine acetylation disrupts association with chromatin, hence promoting PCNA ubiquitination and proteasomal degradation in response to UV damage in a CREBBP- and EP300-dependent manner. Acetylation disrupts interaction with NUDT15 and promotes degradation (By similarity).
messages: Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (By similarity).
messages: Belongs to the PCNA family.
messages: Homotrimer. Interacts with p300/EP300; the interaction occurs on chromatin in UV-irradiated damaged cells. Interacts with CREBBP (via transactivation domain and C-terminus); the interaction occurs on chromatin in UV-irradiated damaged cells. Directly interacts with POLD1, POLD3 and POLD4 subunits of the DNA polymerase delta complex, POLD3 being the major interacting partner; the interaction with POLD3 is inhibited by CDKN1A/p21(CIP1). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with EXO1, POLH, POLK, DNMT1, ERCC5, FEN1, CDC6 and POLDIP2. Interacts with POLB (By similarity). Interacts with APEX2; this interaction is triggered by reactive oxygen species and increased by misincorporation of uracil in nuclear DNA. Forms a ternary complex with DNTTIP2 and core histone (By similarity). Interacts with KCTD10 (PubMed:15982757). Interacts with PPP1R15A (By similarity). Interacts with SMARCA5/SNF2H (By similarity). Interacts with BAZ1B/WSTF; the interaction is direct and is required for BAZ1B/WSTF binding to replication foci during S phase (By similarity). Interacts with HLTF and SHPRH. Interacts with NUDT15. Interaction is disrupted in response to UV irradiation and acetylation. Interacts with CDKN1A/p21(CIP1) and CDT1; interacts via their PIP-box which also recruits the DCX(DTL) complex. The interaction with CDKN1A inhibits POLD3 binding. Interacts with DDX11. Interacts with EGFR; positively regulates PCNA. Interacts with PARPBP. Interacts (when ubiquitinated) with SPRTN; leading to enhance RAD18-mediated PCNA ubiquitination. Interacts (when polyubiquitinated) with ZRANB3. Interacts with SMARCAD1. Interacts with CDKN1C. Interacts with PCLAF (via PIP-box). Interacts with RTEL1 (via PIP-box); the interaction is direct and essential for the suppression of telomere fragility. Interacts with FAM111A (via PIP-box); the interaction is direct and required for PCNA loading on chromatin binding. Interacts with LIG1. Interacts with SETMAR. Interac…
messages: Methylated on glutamate residues by ARMT1.
messages: Nucleus
messages: Phosphorylated. Phosphorylation at Tyr-211 by EGFR stabilizes chromatin-associated PCNA (By similarity).
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
messages: Ubiquitinated. Following DNA damage, can be either monoubiquitinated to stimulate direct bypass of DNA lesions by specialized DNA polymerases or polyubiquitinated to promote recombination-dependent DNA synthesis across DNA lesions by template switching mechanisms. Following induction of replication stress, monoubiquitinated by the UBE2B-RAD18 complex on Lys-164, leading to recruit translesion (TLS) polymerases, which are able to synthesize across DNA lesions in a potentially error-prone manner. An error-free pathway also exists and requires non-canonical polyubiquitination on Lys-164 through 'Lys-63' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligases, HLTF, RNF8 and SHPRH. This error-free pathway, also known as template switching, employs recombination mechanisms to synthesize across the lesion, using as a template the undamaged, newly synthesized strand of the sister chromatid. Monoubiquitination at Lys-164 also takes place in undamaged proliferating cells, and is mediated by the DCX(DTL) complex, leading to enhance PCNA-dependent translesion DNA synthesis. Sumoylated during S phase (By similarity).

10116:Agtrap
gene id: 10116:Agtrap
uniprot id: A6IU47
uniprot id: Q642A2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway. Attenuates type-1 angiotensin II receptor growth promoting effect and angiotensin II-induced phosphorylation of protein kinase AKT and of STAT3.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Interacts with RACK1, and with the carboxy-terminal region of AGTR1.
messages: Membrane

10116:Aldh1a3
gene id: 10116:Aldh1a3
uniprot id: Q8K4D8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (Probable). High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity (By similarity). Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (By similarity).
messages: Cytoplasm
messages: Homotetramer.

10116:Procr
gene id: 10116:Procr
uniprot id: Q4V8I1
names: Function
names: Subcellular Location Annotation
messages: Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation (By similarity).
messages: Membrane

10116:Nap1l1
gene id: 10116:Nap1l1
uniprot id: A0A8I6AE93
uniprot id: A0A8I6AKV9
uniprot id: A6IGG5
uniprot id: A6IGG8
uniprot id: A6IGG9
uniprot id: Q9Z2G8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleosome assembly protein (NAP) family.
messages: Cytoplasm
messages: Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity).
messages: Homodimer. The dimer binds strongly and sequentially to single and double H2A-H2B heterodimers. Interacts with ERCC6; this interaction increases ERCC6 processivity. Interacts with RAD54 (By similarity). Interacts with SETD1A (By similarity).
messages: Melanosome
messages: Nucleus
messages: Polyglutamylated by TTLL4 on glutamate residues, resulting in polyglutamate chains on the gamma-carboxyl group. Both polyglutamylation and polyglycylation modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally.
messages: Polyglycylated by TTLL10 on glutamate residues, resulting in polyglycine chains on the gamma-carboxyl group. Both polyglutamylation and polyglycylation modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally.
messages: The NAP1L motif is required for the histone chaperone activity.
messages: The acidic domains are probably involved in the interaction with histones.

10116:Rundc3b
gene id: 10116:Rundc3b
uniprot id: A0A0G2JVF1
uniprot id: A6K237
uniprot id: Q3B7K9
names: Similarity
names: Subunit
messages: Belongs to the RUNDC3 family.
messages: Interacts with RAP2A.

10116:Cfap97d2
gene id: 10116:Cfap97d2
uniprot id: A0A8I6A9L5
names: Similarity
messages: Belongs to the CFAP97 family.

10116:Map4k1
gene id: 10116:Map4k1
uniprot id: A6J9M5
uniprot id: D3Z8I4
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

10116:Cyp2d2
gene id: 10116:Cyp2d2
uniprot id: P10634
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

10116:Kcna7
gene id: 10116:Kcna7
uniprot id: A6JB24
uniprot id: D4A810
names: Subcellular Location Annotation
messages: Membrane

10116:Dnaaf2
gene id: 10116:Dnaaf2
uniprot id: Q5FVL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIH1 family. Kintoun subfamily.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Interacts with CFAP300. Interacts with DNAI2 and HSPA1A. Interacts with DNAAF4. Interacts with DNAAF6/PIH1D3.
messages: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.

10116:Oaz1
gene id: 10116:Oaz1
uniprot id: P54370
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the ODC antizyme family.
messages: Induced by a ribosomal frameshifting mechanism in response to increased levels of intracellular polyamines.
messages: Interacts with ODC1 and thereby sterically blocks ODC homodimerization. Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome. Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1. Interacts with FAM171A1 (By similarity).
messages: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination (By similarity). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter (PubMed:8166639). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity).

10116:Flrt2
gene id: 10116:Flrt2
uniprot id: D3ZTV3
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Detected in brain (at protein level).
messages: Endoplasmic reticulum membrane
messages: Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.
messages: Microsome membrane
messages: N-glycosylated.
messages: Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease.
messages: Secreted
messages: Self-associates (via leucine-rich repeats), giving rise to homooligomers. Interacts with FGFR1. Interacts with FGFR2. Interacts (via extracellular domain) with ADGRL1/LPHN1 (By similarity). Interacts (via extracellular domain) with ADGRL3 (via olfactomedin-like domain) (PubMed:22405201). Interacts (via extracellular domain) with UNC5D (via the first Ig-like domain). Can also interact (via extracellular domain) with UNC5B, but with much lower affinity. Interacts (via extracellular domain) with FN1 (By similarity).
messages: extracellular matrix
messages: focal adhesion
messages: synaptosome

10116:Fmo3
gene id: 10116:Fmo3
uniprot id: A0A0G2JSI0
uniprot id: A6IDB5
uniprot id: Q9EQ76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FMO family.
messages: Detected in liver and kidney (at protein level) (PubMed:19307449). Expressed in kidney and liver. Weakly expressed in lung. Does not seem to be expressed in brain, adipose tissue, or muscle.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:3739217, PubMed:7736906). Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Membrane
messages: Microsome membrane

10116:Cd5l
gene id: 10116:Cd5l
uniprot id: A6J603
uniprot id: F7F1I5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Cpne4
gene id: 10116:Cpne4
uniprot id: A0A8I6GKR1
uniprot id: A6I2M2
uniprot id: F1M0Z3
uniprot id: H1UBM8
names: Similarity
messages: Belongs to the copine family.

10116:Gne
gene id: 10116:Gne
uniprot id: O35826
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Allosterically regulated (By similarity); feedback inhibited by cytidine monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac), the end product of neuraminic acid biosynthesis. Activity is dependent on oligomerization. The monomer is inactive, whereas the dimer catalyzes only the phosphorylation of N-acetylmannosamine, and the hexamer is fully active for both enzyme activities. Up-regulated after PKC-dependent phosphorylation.
messages: Cytoplasm
messages: Homodimer and homohexamer.
messages: In the C-terminal section; belongs to the ROK (NagC/XylR) family.
messages: In the N-terminal section; belongs to the UDP-N-acetylglucosamine 2-epimerase family.
messages: Phosphorylated by PKC.
messages: Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. Plays an essential role in early development (By similarity).
messages: Widely expressed. Highest expression is observed in liver.

10116:Psip1
gene id: 10116:Psip1
uniprot id: F7FJ14
uniprot id: Q812D1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HDGF family.
messages: Citrullinated by PADI4.
messages: Monomer (By similarity). Interacts with IFRD1/PC4 (By similarity). Interacts (via IBD domain) with POGZ (via IBM motif) and CDCA7L (via IBM motifs) (By similarity). Interacts (via IBD domain) with KMT2A (via IBM motifs) with a moderate affinity whereas interacts with the KMT2A-MEN1 complex with a greater affinity; MEN1 enhances interaction of KMT2A with PSIP1 (By similarity). Interacts (via IBD domain) with IWS1 (via IBM motif), MED1 (via IBM motif) and DBF4 (via IBM motifs) (By similarity).
messages: Nucleus
messages: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity).

10116:Acly
gene id: 10116:Acly
uniprot id: A6HJ38
uniprot id: A6HJ39
uniprot id: G3V888
uniprot id: G3V9G4
uniprot id: P16638
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated at Lys-539, Lys-545 and Lys-553 by KAT2B/PCAF (By similarity). Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites (By similarity). Acetylation promotes de novo lipid synthesis (By similarity). Deacetylated by SIRT2 (By similarity).
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Expressed in the brain, kidney, mammary gland, lung and liver.
messages: Homotetramer.
messages: ISGylated.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.
messages: Phosphorylated by PKA and GSK3 in a sequential manner; phosphorylation results in activation of its activity (By similarity). Phosphorylation on Thr-446 and Ser-450 depends on the phosphorylation state of Ser-454 (PubMed:12107176, PubMed:2176822). Phosphorylation on Ser-454 is decreased by prior phosphorylation on the other 2 residues (PubMed:12107176, PubMed:2176822).
messages: Phosphorylation results in activation of its activity (By similarity). Glucose 6-phosphate, fructose 6-phosphate, fructose 2,6-bisphosphate, ribulose 5-phosphate, and fructose 1,6-bisphosphate also act as activators (By similarity).
messages: The N-terminus is blocked.
messages: Ubiquitinated at Lys-539, Lys-545 and Lys-553 by the BCR(KLHL25) E3 ubiquitin ligase complex and UBR4, leading to its degradation (By similarity). Ubiquitination is probably inhibited by acetylation at same site (By similarity). BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells (By similarity).
messages: cytosol

10116:Smim13
gene id: 10116:Smim13
uniprot id: D3ZR35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM13 family.
messages: Membrane

10116:Rab19
gene id: 10116:Rab19
uniprot id: A6IEU7
uniprot id: Q5M7U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

10116:Sin3a
gene id: 10116:Sin3a
uniprot id: A6J4S5
names: Subcellular Location Annotation
messages: Nucleus

10116:Cby1
gene id: 10116:Cby1
uniprot id: Q8K4I6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 'Chibby' is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.
messages: Belongs to the chibby family.
messages: Golgi apparatus
messages: Homodimer. Interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of CTNNB1. Interacts (C-terminus) with TCIM (C-terminus), TCIM competes with CTNNB1 for the interaction with CBY1. Interacts with FAM92A; this interaction facilitates targeting of FAM92A to cilium basal body. Interacts with CIBAR2.
messages: Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
messages: Nucleus speckle
messages: centriole
messages: cilium basal body
messages: trans-Golgi network

10116:Sh3pxd2b
gene id: 10116:Sh3pxd2b
uniprot id: M0RCP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3PXD2 family.
messages: Cytoplasm

10116:Dgkq
gene id: 10116:Dgkq
uniprot id: D3ZEY4
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by phosphatidylserine.
messages: Belongs to the eukaryotic diacylglycerol kinase family.
messages: Cell membrane
messages: Cytoplasm
messages: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15337525). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:15337525). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (By similarity). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (PubMed:15337525). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (By similarity).
messages: Interacts with RHOA (constitutively activated, GTP-bound); the interaction inhibits DGKQ. Interacts with PRKCE. Interacts with PRKCH. Interacts with PLCB1. Interacts with NR5A1; the interaction requires both LXXLL motifs in DGKQ and is required for full phosphatidic acid-mediated activation of NR5A1.
messages: Nucleus
messages: Nucleus matrix
messages: Nucleus speckle
messages: Phosphorylated by PRKCE and PRKCH in vitro.
messages: Synapse
messages: The L-X-X-L-L repeats are both required for binding and phosphatidic acid-mediated activation of the nuclear receptor NR5A1.
messages: Widely expressed with higher expression in the brain and, to a lesser extent, in the small intestine, duodenum, and liver (PubMed:9099683). In brain, expressed in gray matter (PubMed:9099683). Expression is most intense in the cerebellar cortex and hippocampus, while moderate expression is seen in the olfactory bulb neuronal layers and brain stem nuclei (PubMed:9099683). In the cerebellar cortex, equally expressed in both the Purkinje cell somata and the granule cells (PubMed:9099683).
messages: cytoskeleton
messages: cytosol

10116:Nat2
gene id: 10116:Nat2
uniprot id: A6KFK5
uniprot id: G3V9K9
uniprot id: P50298
uniprot id: Q45G59
names: Function
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arylamine N-acetyltransferase family.
messages: Cytoplasm
messages: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Acetylates only arylamines.
messages: There are two forms of NAT2: a rapid isoform (NAT2*21A) and a slow isoform (NAT2*21B).

10116:Tmco5b
gene id: 10116:Tmco5b
uniprot id: D3ZEL3
names: Subcellular Location Annotation
messages: Membrane

10116:Arsk
gene id: 10116:Arsk
uniprot id: Q32KJ2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate (By similarity). Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate (By similarity). Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate (By similarity).
messages: Lysosome
messages: N-glycosylated with both high mannose and complex type sugars.
messages: Secreted
messages: The 75-kDa precursor undergoes proteolytic processing to yield a 23 kDa form.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

10116:Rilpl1
gene id: 10116:Rilpl1
uniprot id: D3ZUQ0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RILPL family.
messages: Highly expressed in heart, skeletal muscle, brain and lung (at protein level).
messages: Interacts (when S-nitrosylated) with GAPDH (PubMed:19607794). Interacts with RAB8A; interaction is dependent on the phosphorylation of 'Thr-72' of RAB8A (By similarity). Interacts with RAB10 and RAB12; the interaction is dependent on the phosphorylation of 'Thr-73' of RAB10, and 'Ser-105' of RAB12 (By similarity).
messages: Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (PubMed:19607794). Competes with SIAH1 for binding GAPDH (PubMed:19607794). Does not regulate lysosomal morphology and distribution (By similarity). Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (By similarity).
messages: S-nitrosylation is required for the interaction with GAPDH.
messages: centriole
messages: cilium basal body
messages: cytosol

10116:Mug1
gene id: 10116:Mug1
uniprot id: Q03626
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective.
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Expression level in the liver as well as protein level in plasma down-regulated by up to 70% during acute inflammation or tumor development.
messages: Monomer.
messages: Plasma.
messages: Secreted

10116:Slc47a1
gene id: 10116:Slc47a1
uniprot id: A0A8I6A976
uniprot id: Q5I0E9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Cell membrane
messages: Highly expressed in kidney and placenta, moderately in stomach, colon, lung, spleen, skeletal muscle and prostate, and slightly in spleen. In the kidney, found in medulla and cortex, especially in the proximal convoluted and straight tubules. No expression was observed in heart, brain, small intestine and liver. Expressed in Sertoli cells in testis (PubMed:17616214).
messages: Mediates the efflux of cationic compounds such as the model cations, tetraethylammonium (TEA), the neurotoxin 1-methyl-4-phenylpyridinium (MPP), the platinum-based drugs cisplatin and oxaliplatin, the drugs procainamide, acyclovir and topotecan, or weak bases that are positively charged at physiological pH, such as cimetidine or the antidiabetic drug metformin.
messages: Membrane
messages: Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:17047166). Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16928787, PubMed:16850272, PubMed:17047166, PubMed:17582384, PubMed:17327464). Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16928787, PubMed:16850272, PubMed:17047166, PubMed:17582384, PubMed:17327464). May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable).

10116:Or5an9
gene id: 10116:Or5an9
uniprot id: D3ZC12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ptgfrn
gene id: 10116:Ptgfrn
uniprot id: Q62786
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Endoplasmic reticulum membrane
messages: Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration (By similarity).
messages: Interacts with CD9 and CD81 (By similarity). Part of a complex composed of CD9, CD81 and IGSF8 (By similarity). Also seems to interact with CD63, CD82 and CD151 (By similarity).
messages: Reproductive tissues, lung and heart.
messages: trans-Golgi network membrane

10116:Chek1
gene id: 10116:Chek1
uniprot id: A6KRN1
uniprot id: Q91ZN7
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated through phosphorylation predominantly by ATR but also by ATM in response to DNA damage or inhibition of DNA replication. Activation is modulated by several mediators including CLSPN, BRCA1 and FEM1B. Proteolytic cleavage at the C-terminus by SPRTN during normal DNA replication activates the protein kinase activity.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
messages: Chromosome
messages: Cytoplasm
messages: Expressed in brain, heart, liver, lung, skeletal muscle, spleen and testis.
messages: Expressed only in liver.
messages: Interacts (phosphorylated by ATR) with RAD51. Interacts with and phosphorylates CLSPN, an adapter protein that regulates the ATR-dependent phosphorylation of CHEK1. Interacts with BRCA1. Interacts with and phosphorylates CDC25A, CDC25B and CDC25C. Interacts with FBXO6, which regulates CHEK1. Interacts with PPM1D, which regulates CHEK1 through dephosphorylation. Interacts with TIMELESS; DNA damage-dependent. Interacts with FEM1B; activates CHEK1 in response to stress. Interacts with TLK1. Interacts with XPO1 and YWHAZ. Interacts with CDK5RAP3; antagonizes CHEK1.
messages: Nucleus
messages: Phosphorylated by ATR in a RAD17-dependent manner in response to ultraviolet irradiation and inhibition of DNA replication. Phosphorylated by ATM in response to ionizing irradiation. ATM and ATR can both phosphorylate Ser-317 and Ser-345 and this results in enhanced kinase activity. Phosphorylation at Ser-345 induces a change in the conformation of the protein, activates the kinase activity and is a prerequisite for interaction with FBXO6 and subsequent ubiquitination at Lys-436. Phosphorylation at Ser-345 also increases binding to 14-3-3 proteins and promotes nuclear retention. Conversely, dephosphorylation at Ser-345 by PPM1D may contribute to exit from checkpoint mediated cell cycle arrest. Phosphorylation at Ser-280 by AKT1/PKB, may promote mono and/or diubiquitination. Also phosphorylated at undefined residues during mitotic arrest, resulting in decreased activity (By similarity).
messages: Proteolytically cleaved at the C-terminus by SPRTN during normal DNA replication, thereby promoting CHEK1 removal from chromatin and activating the protein kinase activity.
messages: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Also phosphorylates NEK6. Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination. Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation. Also promotes repair of DNA cross-links through phosphorylation of FANCE. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may enhance chromatin assembly both in the presence or absence of DNA damage. May also play a role in replication fork maintenance through regulation of PCNA (By similarity). May regulate the transcription of genes that regulate cell-cycle progressi…
messages: The autoinhibitory region (AIR) inhibits the activity of the kinase domain.
messages: Ubiquitinated. Mono or diubiquitination promotes nuclear exclusion. The activated form (phosphorylated on Ser-345) is polyubiquitinated at Lys-436 by some SCF-type E3 ubiquitin ligase complex containing FBXO6 promoting its degradation. Ubiquitination and degradation are required to terminate the checkpoint and ensure that activated CHEK1 does not accumulate as cells progress through S phase, when replication forks encounter transient impediments during normal DNA replication. 'Lys-63'-mediated ubiquitination by TRAF4 at Lys-132 activates cell cycle arrest and activation of DNA repair (By similarity).
messages: centrosome

10116:Cd59b
gene id: 10116:Cd59b
uniprot id: P27274
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cell membrane
messages: N-glycosylated.
messages: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts at or after the C5b-8 stage of MAC assembly.

10116:Dbn1
gene id: 10116:Dbn1
uniprot id: Q07266
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (By similarity). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (By similarity). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity).
messages: Brain neurons.
messages: Cell junction
messages: Cell projection
messages: Cytoplasm
messages: Drebrins are classified into two forms of the embryonic type (E1 and E2) and one form of the adult type (A). The time course of their appearance are different from each other. Their structures are closely related. Adult rat brain expresses only drebrin A while drebrin E1 or E2 is observed in immature animals.
messages: ISGylated.
messages: Interacts with RUFY (By similarity). Interacts with CXCR4; this interaction is enhanced by antigenic stimulation (By similarity). Interacts (via ADF-H domain) with ZMYND8 (via N-terminus); the interaction leads to sequestering of ZMYND8 in the cytoplasm (By similarity).
messages: cell cortex
messages: dendrite
messages: growth cone

10116:Or5b3
gene id: 10116:Or5b3
uniprot id: A0A8I5ZM16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ddx28
gene id: 10116:Ddx28
uniprot id: A6IYV3
uniprot id: D4A7Q5
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

10116:Scgb1d4
gene id: 10116:Scgb1d4
uniprot id: A6HZZ5
uniprot id: P02781
uniprot id: Q499V5
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the secretoglobin family. Lipophilin subfamily.
messages: Linked by three disulfide bonds to C3.
messages: Part of prostatein which is the major secretory glycoprotein of ventral prostate gland.
messages: Prostatein is composed of three different peptides called C1, C2 and C3. These form covalent C1:C3 (F) and C2:C3 (S) heterodimers whose noncovalent association forms tetrameric (C1:C3/C3:C2) prostatein molecules.
messages: Secreted
messages: The N-terminus is blocked.
messages: The heterodimer can bind non-polar steroids, cholesterol and a group of small proline-rich peptides.

10116:Firrm
gene id: 10116:Firrm
uniprot id: Q5XI94
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts (via its N-terminal region) with PLK1; controls PLK1 kinase activity. Interacts (via the KVVXF motif) with PPP1CC; controls PLK1 kinase activity. Interacts with FIGNL1; may regulate homologous recombination.
messages: Midbody
messages: Nucleus
messages: Phosphorylation at Ser-101 by PLK1 strengthens FIRRM-PLK1 interaction. Phosphorylation at Ser-796 by PLK1 negatively regulates its interaction with PPP1CC.
messages: Regulates PLK1 kinase activity at kinetochores and promotes faithful chromosome segregation in prometaphase by bridging kinase and phosphatase activities. Phosphorylation of FIRRM by PLK1 negatively regulates its interaction with the phosphatase, PPP1CC, thus creating a negative feedback loop for maintaining proper PLK1 kinase activity during mitosis. In complex with FIGL1 may regulate homologous recombination.
messages: centromere
messages: kinetochore
messages: spindle

10116:Kbtbd8
gene id: 10116:Kbtbd8
uniprot id: B1H285
uniprot id: F8WFZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KBTBD8 family.
messages: Component of the BCR(KBTBD8) E3 ubiquitin ligase complex, at least composed of CUL3, KBTBD8 and RBX1.
messages: Golgi apparatus
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
messages: spindle

10116:Tecrl
gene id: 10116:Tecrl
uniprot id: A6JCS7
uniprot id: D4A1Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

10116:Rfng
gene id: 10116:Rfng
uniprot id: A0A0G2K5T8
uniprot id: A6HLJ5
uniprot id: M0RD65
uniprot id: Q6P6T7
uniprot id: Q9R1U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 31 family.
messages: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1 (By similarity). Inhibits Notch signaling in postmitotic neurons of the brain. It may play a role in adult brain and in neurogenesis (PubMed:11165380). It may play a role in limb development (By similarity).
messages: Golgi apparatus membrane
messages: Membrane
messages: Most abundantly expressed in adult brain. Expressed in most neurons of the brain but not in glial cells. Also detected to a lower extent in adult lung and kidney.

10116:Hsp90aa1
gene id: 10116:Hsp90aa1
uniprot id: A6KBM6
uniprot id: P82995
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer (By similarity). Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1, HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C or STIP1 (By similarity). Forms a complex containing HSP90AA1, TSC1 and TSC2; TSC1 is required to recruit TCS2 to the complex (By similarity). The closed form interacts (via the middle domain and TPR repeat-binding motif) with co-chaperone TSC1 (via C-terminus) (By similarity). Interacts with TOM34 (By similarity). Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex (By similarity). Interacts with CHORDC1 and DNAJC7 (By similarity). Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems (By similarity). Interacts (via TPR repeat-binding motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity (By similarity). Following LPS binding, may form a complex with CXCR4, GDF5 and HSPA8 (By similarity). Interacts with KSR1 (By similarity). Interacts with co-chaperone CDC37 (via C-terminus); the interaction inhibits HSP90AA1 ATPase activity (By similarity). May interact with NWD1 (By similarity). Interacts with FNIP1 and FNIP2; the interaction inhibits HSP90AA1 ATPase activity (By similarity). Interacts with co-chaperone AHSA1 (phosphorylated on 'Tyr-223'); the interaction activates HSP90AA1 ATPase activity and results in the dissociation of TSC1 from HSP90AA1 (By similarity). Interacts with FLCN in the presence of FNIP1 (By similarity). Interacts with HSP70, STIP1 and PTGES3 (By similarity). Interacts with SGTA (via TPR repeats) (PubMed:15708368). Interacts with SMYD3; this interaction enhances SMYD3 histone-lysine N-methyltransferase (By similarity). Interacts with TTC1 (via TPR repeats) (By similarity). Interacts with HSF1 in an ATP-dependent manner (By similarity). Interacts with MET; the interaction suppres…
messages: ISGylated.
messages: In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state. Co-chaperone TSC1 promotes ATP binding and inhibits HSP90AA1 ATPase activity. Binding to phosphorylated AHSA1 promotes HSP90AA1 ATPase activity. Inhibited by geldanamycin, Ganetespib (STA-9090) and SNX-2112.
messages: Melanosome
messages: Mitochondrion
messages: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antagonizes S…
messages: Nucleus
messages: S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1.
messages: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1.
messages: Ubiquitinated via 'Lys-63'-linked polyubiquitination by HECTD1. Ubiquitination promotes translocation into the cytoplasm away from the membrane and secretory pathways.

10116:Casr
gene id: 10116:Casr
uniprot id: A6IRC6
uniprot id: P48442
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7816802). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (By similarity).
messages: Homodimer; disulfide-linked (By similarity). Interacts with VCP and RNF19A (By similarity). Interacts with ARRB1 (PubMed:17623778).
messages: In resting state, adopts an open conformation, anion-binding promoting the inactive configuration. Upon aromatic amino acid-binding, the groove in the extracellular venus flytrap module is closed, thereby inducing the formation of a novel homodimer interface between subunits. Calcium ions stabilize the active state by enhancing homodimer interactions between membrane-proximal domains to fully activate the receptor.
messages: Membrane
messages: N-glycosylated.
messages: The extracellular regions of the homodimer interact in a side-by-side fashion while facing opposite directions. Each extracellular region consists of three domains, LB1 (ligand-binding 1), LB2 and CR (cysteine-rich). The two lobe-shaped domains LB1 and LB2 form a venus flytrap module. In the inactive configuration, the venus flytrap modules of both protomers are in the open conformation associated with the resting state (open-open) and the interdomain cleft is empty. In addition, each protomer contains three anions, which reinforce the inactive conformation, and one calcium ion. In the active configuration, both protomers of extracellular regions have the closed conformation associated with agonist-binding (closed-closed). The ligand-binding cleft of each protomer is solely occupied by an aromatic amino-acid. Calcium is bound at four novel sites, including one at the homodimer interface. Agonist-binding induces large conformational changes within the extracellular region homodimer: first, the venus flytrap module of each protomer undergoes domain closure. Second, the LB2 regions of the two protomers approach each other, resulting in an expansion of the homodimer interactions involving LB2 domains. Third, the CR regions of the two subunits interact to form a large homodimer interface that is unique to the active state. The CR regions are brought into close contact by the motion involving LB2 since the two domains are rigidly associated within each subunit.
messages: Ubiquitinated by RNF19A; which induces proteasomal degradation.

10116:Fgfr3
gene id: 10116:Fgfr3
uniprot id: A0A0G2K210
uniprot id: F1LSN4
uniprot id: Q9JHX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

10116:Nadk2
gene id: 10116:Nadk2
uniprot id: A0A096MKG5
uniprot id: A0A8I5ZQT4
uniprot id: Q1HCL7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homodimer.
messages: Inhibited by NADH, NADPH and NADP(+).
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor (By similarity).
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
messages: Mitochondrion

10116:Ldah
gene id: 10116:Ldah
uniprot id: Q5HZX7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Endoplasmic reticulum
messages: Lipid droplet
messages: Probable serine lipid hydrolase associated with lipid droplets. Appears to lack cholesterol esterase activity. Appears to lack triglyceride lipase activity. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages.
messages: The catalytic activity is unsure despite catalytic sites being conserved.

10116:Fam163b
gene id: 10116:Fam163b
uniprot id: A6JTK5
uniprot id: D3Z988
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

10116:S100a11
gene id: 10116:S100a11
uniprot id: A6KMM4
uniprot id: Q6B345
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the S-100 family.
messages: Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.
messages: Cytoplasm
messages: Facilitates the differentiation and the cornification of keratinocytes.
messages: Homodimer; disulfide-linked.
messages: Nucleus
messages: Phosphorylation at Thr-5 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.

10116:C11h3orf38
gene id: 10116:C11h3orf38
uniprot id: Q66H33
names: Function
messages: May be involved in apoptosis regulation.

10116:Atp1a1
gene id: 10116:Atp1a1
uniprot id: P06685
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Expressed in the central nervous system, in most motor and sensory axons of the ventral and dorsal roots, as well as in the large motor neurons of the ventral horn (at protein level).
messages: Melanosome
messages: Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity.
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with regulatory subunit FXYD1 (PubMed:17283221, PubMed:19339511, PubMed:23532852). Interacts with regulatory subunit FXYD3 (PubMed:15743908). Interacts with SLC35G1 and STIM1 (By similarity). Interacts with SIK1 (PubMed:17939993). Interacts with CLN3; this interaction regulates the sodium/potassium-transporting ATPase complex localization at the plasma membrane (By similarity).
messages: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
messages: axon
messages: sarcolemma

10116:Ubap1
gene id: 10116:Ubap1
uniprot id: Q5XIS7
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with PTPN23. Interacts (via UBA domains) with ubiquitinated proteins.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2.
messages: Endosome
messages: The UMA domain mediates association with the ESCRT-I complex.
messages: cytosol

10116:Naga
gene id: 10116:Naga
uniprot id: A6HT60
uniprot id: Q66H12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome
messages: Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids.

10116:Atp1b4
gene id: 10116:Atp1b4
uniprot id: Q9R193
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Does not associate with known Na,K-ATPase alpha-subunits (By similarity). Associates with a SMAD7-transcriptional complex. Interacts with SNW1 and TOR1AIP1.
messages: Expressed in perinatal myocytes (at protein level). Expressed during postnatal development in skeletal muscle and heart.
messages: May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity).
messages: Nucleus inner membrane

10116:Hikeshi
gene id: 10116:Hikeshi
uniprot id: A6I613
uniprot id: Q5M808
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus (By similarity).
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins. Interacts with NUP62 and NUP153 (via F-X-F-G repeats). Interacts with HSPA8.
messages: Nucleus
messages: cytosol

10116:Taf13
gene id: 10116:Taf13
uniprot id: A0A9K3Y8H1
uniprot id: B2RYQ7
names: Subcellular Location Annotation
messages: Nucleus

10116:Glo1
gene id: 10116:Glo1
uniprot id: A6JJX3
uniprot id: Q6P7Q4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:8719777). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity). Required for normal osteoclastogenesis (By similarity).
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
messages: Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses the TNF-induced transcriptional activity of NF-kappa-B (By similarity).
messages: Glutathionylation at Cys-139 inhibits enzyme activity.
messages: Homodimer.
messages: Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2 so phosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses the TNF-induced transcriptional activity of NF-kappa-B (By similarity).

10116:Atg3
gene id: 10116:Atg3
uniprot id: Q6AZ50
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG3 family.
messages: Cleaved by CASP8 upon death ligand binding such as tumor necrosis factor-alpha. CASP8 cleavage blocks survival-related autophagy and favors apoptosis (By similarity).
messages: Conjugated to ATG12 at Lys-243. ATG12-conjugation plays a role in regulation of mitochondrial homeostasis and cell death, while it is not involved in PE-conjugation to ATG8-like proteins and autophagy (By similarity).
messages: Cytoplasm
messages: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3 (By similarity).
messages: Interacts with ATG7 and ATG12. The complex composed of ATG3 and ATG7 plays a role in the conjugation of ATG12 to ATG5. Interacts with FNBP1L.

10116:Cdc42bpb
gene id: 10116:Cdc42bpb
uniprot id: A6KBQ3
uniprot id: Q7TT49
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in all tissues examined with highest levels in lung and kidney.
messages: Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42 (By similarity). Interacts with TJP1; this interaction requires the presence of catalytically active CDC42 (PubMed:21240187). Forms a tripartite complex with MYO18A and LURAP1 with the latter acting as an adapter connecting CDC42BPB and MYO18A. LURAP1 binding results in activation of CDC42BPB by abolition of its negative autoregulation (PubMed:18854160). Interacts with STRIP1, STRN3 and SIKE1 (By similarity). Interacts with CPNE4 (via VWFA domain) (By similarity). Interacts with LURAP1 (PubMed:25107909). Interacts (via AGC-kinase C-terminal domain) with FAM89B/LRAP25 (via LRR repeat) (PubMed:25107909). Forms a tripartite complex with FAM89B/LRAP25 and LIMK1 (By similarity).
messages: Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation (By similarity). Inhibited by chelerythrine chloride.
messages: Proteolytically cleaved by caspases upon apoptosis induction.
messages: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21240187, PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A (PubMed:18854160). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity).
messages: lamellipodium

10116:Gstt4
gene id: 10116:Gstt4
uniprot id: A6JKG7
uniprot id: Q4V8E6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.

10116:Add1
gene id: 10116:Add1
uniprot id: A0A8I5Y1E2
uniprot id: A0A8I6ALT1
uniprot id: D3ZZ99
uniprot id: Q63028
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Cell membrane
messages: Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.
messages: Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit.
messages: Membrane
messages: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
messages: cytoskeleton

10116:Ppef2
gene id: 10116:Ppef2
uniprot id: A6KKA0
uniprot id: D3ZN69
names: Similarity
messages: Belongs to the PPP phosphatase family.

10116:Chp1
gene id: 10116:Chp1
uniprot id: P61023
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calcineurin regulatory subunit family. CHP subfamily.
messages: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.
messages: Cell membrane
messages: Cytoplasm
messages: Endomembrane system
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Expressed in liver and kidney (at protein level). Ubiquitously expressed. Expressed in the brain, lung, testes, kidney, spleen and heart.
messages: Interacts with PPP3CA. Interacts with SLC9A1/NHE1 (via the juxtamembrane region of the cytoplasmic C-terminal domain); the interaction occurs at the plasma membrane in a calcium-dependent manner and at a domain that is critical for growth factor stimulation of the exchanger (By similarity). Monomer. Interacts with STK17B; the interaction occurs in a calcium-independent manner and induces the translocation of CHP1 from the Golgi to the nucleus. Interacts with GAPDH; the interaction is direct, occurs in a N-myristoylation-dependent manner and facilitates the ability of CHP1 to bind microtubules. Interacts with KIF1B (via the C-terminal end of the kinesin-motor domain); the interaction occurs in a calcium-dependent manner. Associates (via C-terminal domain) with microtubules; the association occurs with polymerized microtubules during the cell cycle in a myristoylation- and calcium-independent manner and is enhanced by GAPDH. Interacts with SLC9A3; increases SLC9A3 trafficking and activity at the plasma membrane (By similarity).
messages: Membrane
messages: N-myristoylation is required for its association with microtubules and interaction with GAPDH, but not for the constitutive association to membranes. Both N-myristoylation and calcium-mediated conformational changes are essential in exocytic traffic.
messages: Nucleus
messages: Phosphorylated; decreased phosphorylation is associated with an increase in SLC9A1/NHE1 Na(+)/H(+) exchange activity. Phosphorylation occurs in serum-dependent manner. The phosphorylation state may regulate the binding to SLC9A1/NHE1 (By similarity).
messages: cytoskeleton

10116:Cryl1
gene id: 10116:Cryl1
uniprot id: A6KHB5
uniprot id: Q811X6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: Cytoplasm
messages: Has high L-gulonate 3-dehydrogenase activity. It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate.
messages: Homodimer.
messages: Inhibited by malonate.

10116:Ubtf
gene id: 10116:Ubtf
uniprot id: P25977
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer (PubMed:10099786). Interacts with TBP (By similarity). Interacts with TAF1A (By similarity). Interacts with PHF6 (By similarity). Interacts with CEBPA (isoform 1 and isoform 4) (PubMed:20075868). Interacts with DDX11 (By similarity). Interacts with NOP53 (By similarity). Interacts with RASL11A (By similarity). Interacts with DHX33 (By similarity). Binds to IRS1 and PIK3CA (By similarity). Interacts with ALKBH2.
messages: Phosphorylated and activated by PIK3CA.
messages: Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element (By similarity).
messages: nucleolus

10116:Snx18
gene id: 10116:Snx18
uniprot id: A6I5R6
uniprot id: D3ZZ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

10116:Vom2r30
gene id: 10116:Vom2r30
uniprot id: F1LVC2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Pabir3
gene id: 10116:Pabir3
uniprot id: A0A8I5ZYL0
uniprot id: D3ZNP4
names: Similarity
messages: Belongs to the FAM122 family.

10116:Pola2
gene id: 10116:Pola2
uniprot id: Q4V8M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

10116:Ecsit
gene id: 10116:Ecsit
uniprot id: A6JNY0
uniprot id: Q5XIC2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein that plays a role in different signaling pathways including TLRs and IL-1 pathways or innate antiviral induction signaling. Plays a role in the activation of NF-kappa-B by forming a signal complex with TRAF6 and TAK1/MAP3K7 to activate TAK1/MAP3K7 leading to activation of IKKs. Once ubiquitinated, interacts with the dissociated RELA and NFKB1 proteins and translocates to the nucleus where it induces NF-kappa-B-dependent gene expression. Plays a role in innate antiviral immune response by bridging the pattern recognition receptors RIGI and MDA5/IFIT1 to the MAVS complex at the mitochondrion (By similarity). Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity).
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the ECSIT family.
messages: Cytoplasm
messages: Interacts with MAP3K1, SMAD4 and TRAF6. Interacts with SMAD1 only after BMP4-treatment (By similarity). Part of the mitochondrial complex I assembly/MCIA complex that comprises at least the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9 and complement subunits such as COA1 and TMEM186. Interacts with NDUFAF1. Interacts with ACAD9. Interacts with TRIM59. Interacts with TMEM70 and TMEM242. Interacts (when ubiquitinated) with NF-kappa-B subunits RELA and NFKB1. Interacts with RIGI, IFIT1 and MAVS; these interactions promote RLR-mediated type I IFN induction. Interacts with SQSTM1; this interaction inhibits TLR4 signaling via functional regulation of the TRAF6-ECSIT complex. Interacts with cereblon/CRBN; this interaction inhibits the ubiquitination of ECSIT (By similarity).
messages: Mitochondrion
messages: Nucleus
messages: Ubiquitinated on Lys-371; leading to translocation in the nucleus together with RELA and NFKB1 and expression of NF-kappa-B-dependent genes.

10116:Or5p59
gene id: 10116:Or5p59
uniprot id: D4A403
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Thap4
gene id: 10116:Thap4
uniprot id: Q642B6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.
messages: Cytoplasm
messages: Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region.
messages: Homodimer.
messages: In the C-terminal section; belongs to the nitrobindin family.
messages: Nucleus
messages: The C-terminal nitrobindin region coordinates a heme and bears the isomerase activity. The N-terminal zinc finger domain likely binds DNA and may be involved in transcriptional regulation.

10116:Slc8a2
gene id: 10116:Slc8a2
uniprot id: P48768
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Calcium transport is down-regulated by Na(+) and stimulated by Ca(2+).
messages: Cell membrane
messages: Detected in neocortex and hippocampus on pyramidal cells, astrocyte processes and dendrites (at protein level) (PubMed:16914199). Brain and skeletal muscle.
messages: Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:8021246, PubMed:9486131). Contributes to cellular Ca(2+) homeostasis in excitable cells (By similarity). Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Plays a role in regulating urinary Ca(2+) and Na(+) excretion (By similarity).
messages: Perikaryon
messages: The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium-regulated ion exchange.
messages: dendrite
messages: dendritic spine

10116:Serpinb3a
gene id: 10116:Serpinb3a
uniprot id: A0A8I6AJJ4
names: Similarity
messages: Belongs to the serpin family.

10116:Vom2r67
gene id: 10116:Vom2r67
uniprot id: D3ZQ04
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Glipr1l1
gene id: 10116:Glipr1l1
uniprot id: D3ZI91
names: Similarity
messages: Belongs to the CRISP family.

10116:Arhgap17
gene id: 10116:Arhgap17
uniprot id: Q99N37
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Becomes detectable at the second postnatal week in the cerebral cortex and hippocampus and at the third postnatal week in the cerebellum and olfactory bulb. The expression level is maximal during the third and fourth postnatal weeks and remains high during adulthood. Its expression is closely correlated with neuronal differentiation (at protein level).
messages: Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3. Interacts with NHERF1, FNBP1, TRIP10, CAPZA (CAPZA1, CAPZA2 or CAPZA3), CAPZB, CD2AP and SH3KBP1/CIN85 (By similarity).
messages: Cytoplasm
messages: Highly expressed in brain; neuron-specific (at protein level). Isoform 2, isoform 3 and isoform 4 are predominantly expressed in neuronal tissues and correlate well with the differentiation of neurons, while isoform 1 is strongly expressed in embryonic brain.
messages: Membrane
messages: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere (By similarity). Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.
messages: The BAR domain mediates the interaction with the coiled coil domain of AMOT, leading to its recruitment to tight junctions.
messages: tight junction

10116:Myo9a
gene id: 10116:Myo9a
uniprot id: Q9Z1N3
names: Caution
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cytoplasm
messages: Expressed at high levels in brain, followed by testis and spleen. Expressed at very low levels, in kidney. Detected abundantly in brain and testis and at lower levels in adrenal gland, kidney, lung and spleen (at protein level). In adrenal gland it is mostly found in the medulla but not in the cortex. In brain, it is found in the cerebellum and the CA2-CA3 regions of the hippocampus.
messages: Expressed at high levels in developing forebrain. This expression decreases slightly in embryonic and early postnatal days.
messages: Membrane
messages: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements (PubMed:9819351). Regulates Rho by stimulating it's GTPase activity in neurons (PubMed:9819351). Required for the regulation of neurite branching and motor neuron axon guidance (By similarity).
messages: Phosphorylated by ALPK1 following monosodium urate monohydrate (MSU)-induced inflammation.
messages: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-9 (MYH9).
messages: Synapse
messages: growth cone

10116:Duoxa2
gene id: 10116:Duoxa2
uniprot id: D3ZEJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

10116:Mgat1
gene id: 10116:Mgat1
uniprot id: A6HDW1
uniprot id: Q09325
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Appears to be present in all tissues.
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Interacts with MGAT4D. Interacts with BRI3 (By similarity).
messages: Membrane
messages: The cofactor is mostly bound to the substrate.
messages: perinuclear region

10116:Stx18
gene id: 10116:Stx18
uniprot id: A6IJV2
uniprot id: Q68FW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the syntaxin family.
messages: Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. RINT1/TIP20L and ZW10 are associated with the complex through interaction with BNIP1/SEC20L. Interacts directly with USE1L and BNIP1/SEC20L (By similarity).
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

10116:Olr1226
gene id: 10116:Olr1226
uniprot id: M0R9R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ccnb1
gene id: 10116:Ccnb1
uniprot id: A6I5B4
uniprot id: P30277
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accumulates steadily during G2 and is abruptly destroyed at mitosis.
messages: Belongs to the cyclin family.
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Cytoplasm
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition.
messages: Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization. Interacts with CDK5RAP3. Interacts with RFPL4A and UBE2A. Interacts with INCA1.
messages: Nucleus
messages: Phosphorylated by PLK1 at Ser-123 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-137 was also reported to be mediated by PLK1 but Ser-123 seems to be the primary phosphorylation site (By similarity).
messages: Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases (By similarity).
messages: centrosome

10116:Trhde
gene id: 10116:Trhde
uniprot id: A6IGK0
uniprot id: G3V6Q2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

10116:Mpp3
gene id: 10116:Mpp3
uniprot id: O88954
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Interacts with HTR2C; this interaction stabilizes the receptor at the plasma membrane and prevents the desensitization of the HTR2C receptor-mediated calcium response. Interacts with HTR2A. Interacts with HTR4 (By similarity). Interacts (via PDZ domain) with CADM1 (via C-terminus)Interacts (via PDZ domain) with CADM1; this interaction connects CADM1 with DLG1 (By similarity). Interacts (via Guanylate kinase-like domain) with PALS1 (By similarity). Interacts with DLG1 (via N-terminus); this interaction connects CADM1 with DLG1 and links CADM1 with the regulatory subunit of phosphoinositide-3-kinase (PI3K) by forming a multiprotein complex and participates in cell spreading (By similarity).
messages: Participates in cell spreading through the phosphoinositide-3-kinase (PI3K) pathway by connecting CADM1 to DLG1 and the regulatory subunit of phosphoinositide-3-kinase (PI3K) (By similarity). Stabilizes HTR2C at the plasma membrane and prevents its desensitization. May participates in the maintenance of adherens junctions (By similarity).
messages: adherens junction

10116:Trpv6
gene id: 10116:Trpv6
uniprot id: B6ZDS2
uniprot id: Q9R186
names: Caution
names: Function
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV6 sub-subfamily.
messages: Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:10428857, PubMed:11287959, PubMed:27296226, PubMed:28878326). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:10428857, PubMed:11287959, PubMed:27296226). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).
messages: Cell membrane
messages: Expressed in duodenum, proximal jejunum, cecum, and colon.
messages: Glycosylated.
messages: Homotetramer (PubMed:27296226, PubMed:29258289, PubMed:28878326). Probably forms also heterotetramers with TRPV5. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY. Interacts with TCAF1 and TCAF2 (By similarity).
messages: It is uncertain whether Met-1 or Met-41 is the initiator. In human and mouse, initiation starts at a conserved non-canonical ACG threonine codon decoded as Met-1 upstream of the canonical initiation at Met-41.
messages: Membrane
messages: Phosphorylation at Tyr-201 and Tyr-202 by SRC leads to an increased calcium influx through the channel. Probably dephosphorylated at these sites by PTPN1.
messages: Unusual initiator. The initiator methionine is coded by a non-canonical ACG threonine codon.

10116:Zkscan2
gene id: 10116:Zkscan2
uniprot id: D3ZXU0
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

10116:Usp34
gene id: 10116:Usp34
uniprot id: A0A8I5ZVK3
names: Similarity
messages: Belongs to the peptidase C19 family.

10116:Dtx3l
gene id: 10116:Dtx3l
uniprot id: A6IRE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

10116:Ern2
gene id: 10116:Ern2
uniprot id: A6I8X1
uniprot id: D3ZTI7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:Gimap5
gene id: 10116:Gimap5
uniprot id: A6K0I1
uniprot id: Q0R3W7
uniprot id: Q8K3L6
names: Developmental Stage
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
messages: Diabetes-prone biobreeding (DP-BB) rats have a frameshift mutation in Gimap5, which results in a truncated protein in which the C-terminal 215 amino acids, including the membrane anchor, are replaced by 19 other amino acids. These animals exhibit life-long T-cell lymphopenia, including lack of regulatory T cells, and spontaneously develop insulin-dependent diabetes resembling human type 1 diabetes.
messages: Down-regulated during T lymphocyte activation.
messages: Endosome membrane
messages: Interacts with BAD, BAK1, BAX, BCL2, BCL2L1/Bcl-xL and BCL2L11/BimEL (By similarity). The interaction with BAX is increased, when cells initiate apoptosis upon IL2 withdrawal (By similarity). Forms a complex with BCL2L1 or MCL1 and HSPA8/HSC70; the interaction between HSPA8 and BCL2L1 or MCL1 is impaired in the absence of GIMAP5 (By similarity). May interact (via N-terminus) with microtubules (Probable).
messages: Lysosome membrane
messages: Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (By similarity). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). Promotes the survival of quiescent T-cells (PubMed:15307172). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (PubMed:28223986). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Is a regulator of liver endothelial cell homeostasis (By similarity).
messages: Primarily expressed in spleen, heart, lung and intestine and, at lower levels, in kidney, stomach and muscle (PubMed:12031988). Expressed in thymus and lymph nodes (at protein level) (PubMed:12031988, PubMed:12930893, PubMed:21487483). In the spleen, expressed in periarteriolar lymphatic sheets (PubMed:12031988). Isoform 2: Expressed at higher levels in T lymphocytes compared to isoform 1 (PubMed:28223986).
messages: Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence.
messages: multivesicular body membrane

10116:Arid3a
gene id: 10116:Arid3a
uniprot id: B5DEX9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Nucleus
messages: Transcription factor.

10116:Myog
gene id: 10116:Myog
uniprot id: F7EW09
uniprot id: O70425
uniprot id: P20428
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts.
messages: Expressed in muscle (at protein level).
messages: Homodimer and heterodimer with E12; heterodimerization enhances MYOG DNA-binding and transcriptional activities. Interacts with SMARCA4/BRG1/BAF190A. Interacts (via C-terminal region) with SSRP1 and SUPT16H; the interaction is indicative of an interaction with the FACT complex (By similarity). Interacts with CSRP3.
messages: Nucleus
messages: Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner. Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles.
messages: Up-regulated in denerved muscles cells. Down-regulated in soleus muscle in an electrical activity-dependent manner.

10116:Rps6ka4
gene id: 10116:Rps6ka4
uniprot id: D3ZSB7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

10116:Enpp5
gene id: 10116:Enpp5
uniprot id: A6JJ21
uniprot id: P84039
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Brain.
messages: Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates (By similarity). May play a role in neuronal cell communication. Lacks nucleotide pyrophosphatase and lysopholipase D activity in vitro (PubMed:12927778).
messages: Membrane
messages: N-glycosylated.

10116:Lhx3
gene id: 10116:Lhx3
uniprot id: A6JTC5
uniprot id: G3V8E3
names: Subcellular Location Annotation
messages: Nucleus

10116:Gem
gene id: 10116:Gem
uniprot id: A0A9K3Y811
uniprot id: B5DFA6
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

10116:Apba3
gene id: 10116:Apba3
uniprot id: O70248
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds to the cytoplasmic domain of amyloid protein (APP). Interacts with HIF1AN (via N-terminus) (By similarity). Interacts with NECAB3; seems to mediate the interaction between NECAB3 and HIF1AN (By similarity).
messages: Composed of an N-terminal domain, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.
messages: May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity).
messages: Ubiquitous.
messages: perinuclear region

10116:Sharpin
gene id: 10116:Sharpin
uniprot id: Q9EQL9
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria. LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin. The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
messages: Cytoplasm
messages: Expressed in brain, spleen, lung, heart, skeletal muscle, kidney and testis (at protein level). Expressed in heart and testis.
messages: Monomer and homodimer (PubMed:11178875). Component of the LUBAC complex (linear ubiquitin chain assembly complex) which consists of SHARPIN, RBCK1 and RNF31 (By similarity). LUBAC has a MW of approximately 600 kDa suggesting a heteromultimeric assembly of its subunits (By similarity). Associates with the TNF-R1 signaling complex (TNF-RSC) in a stimulation-dependent manner (By similarity). Interacts with EYA1, EYA2, SHANK1 and SHANK3 (via ANK repeats) (PubMed:11178875, PubMed:23897824).
messages: Synapse
messages: The RanBP2-type zinc fingers mediate the specific interaction with ubiquitin. Binds preferentially linear polyubiquitin chains and 'Lys-63'-linked polyubiquitin chains over 'Lys-48'-linked polyubiquitin chains. Also binds monoubiquitin (By similarity).
messages: The Ubiquitin-like domain is required for the interaction with RNF31.

10116:Ckap2
gene id: 10116:Ckap2
uniprot id: D3ZPD0
names: Similarity
messages: Belongs to the CKAP2 family.

10116:Pomgnt1
gene id: 10116:Pomgnt1
uniprot id: A0A8I6AMP8
uniprot id: A6JZ66
uniprot id: Q5XIN7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Interacts with DAG1 (via O-linked mannose moiety). Interacts (via transmembrane domain) with FKTN; the interaction is direct and is required for normal location in Golgi membranes.
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The GG-type lectin domain is known as the stem domain in POMGnT1. It mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

10116:Mif
gene id: 10116:Mif
uniprot id: A0A0F7RQL3
uniprot id: P30904
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MIF family.
messages: Cytoplasm
messages: Expressed in a wide variety of organs including brain, spleen, liver, muscle and kidney.
messages: Homotrimer (By similarity). Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74 extracellular domain, USO1, COPS5 and BNIPL (By similarity).
messages: Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
messages: Secreted

10116:Tom1l2
gene id: 10116:Tom1l2
uniprot id: A0A8I5ZP70
uniprot id: A0A8I6A1X4
names: Similarity
messages: Belongs to the TOM1 family.

10116:Syt7
gene id: 10116:Syt7
uniprot id: Q62747
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per C2 domain.
messages: Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (PubMed:11395007, PubMed:10725327, PubMed:11511344). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (PubMed:11395007). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:10725327, PubMed:11511344). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages. Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts. Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes. Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters. Probably mediates synaptic facilitation by directly increasing the probability of release. May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin. Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells. Triggers exocytosis by promoting…
messages: Cell membrane
messages: Expressed in the brain (at protein level).
messages: Homodimer. Can also form heterodimers with SYT6, SYT9 and SYT10. Interacts with calmodulin (CALM1, CALM2 or CALM3). Interacts with CD63; required for localization to lysosomes. Interacts with APP (By similarity).
messages: Lysosome membrane
messages: Major isoform.
messages: Palmitoylated at its vesicular N-terminus; palmitoylation is required for localization to lysosome and phagocytosis in macrophages.
messages: Peroxisome membrane
messages: Presynaptic cell membrane
messages: The C2 domains bind Ca(2+) and membranes (PubMed:11823420). Binding to membranes involves Ca(2+)-dependent phospholipid binding (PubMed:11823420). Compared to other members of the family, the C2 domains of SYT7 dock and insert into cellular membranes in response to intracellular Ca(2+) concentrations that are lower than those required for other synaptotagmins. The two C2 domains bind independently to planar membranes, without interdomain cooperativity. Moreover, SYT7 C2 domains insert more deeply into membranes compared to other synaptotagmins (By similarity).
messages: phagosome membrane
messages: secretory vesicle membrane
messages: synaptic vesicle membrane

10116:Ahr
gene id: 10116:Ahr
uniprot id: A6HB96
uniprot id: A6HB97
uniprot id: A6HB98
uniprot id: G3V6M2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

10116:Or11g2
gene id: 10116:Or11g2
uniprot id: D3ZAM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Get3
gene id: 10116:Get3
uniprot id: G3V9T7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer (By similarity). Component of the Golgi to ER traffic (GET) complex, which is composed of GET1/WRB, CAMLG/GET2 and GET3/TRC40 (PubMed:23041287). Within the complex, CAMLG and GET1 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer (By similarity). Interacts with CAMLG/GET2 (via N-terminus) (PubMed:23041287). GET3 shows a higher affinity for CAMLG than for GET1 (By similarity). Interacts with SERP1 and SEC61B (By similarity).
messages: nucleolus

10116:Kmt5b
gene id: 10116:Kmt5b
uniprot id: A6HYL9
uniprot id: P0C2N5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).
messages: Homodimer (By similarity). Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2 (By similarity). Interacts (via C-terminus) with FRG1 (By similarity).
messages: Inhibited by 6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine (A-196). A-196 is competitive with the histone peptide substrate H4K20me1 but non competitive with S-adenosyl-L-methionine.
messages: Nucleus

10116:Or5w15
gene id: 10116:Or5w15
uniprot id: D4A1G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Nsun7
gene id: 10116:Nsun7
uniprot id: A0A8I5ZSS6
uniprot id: Q5XIM6
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Capn7
gene id: 10116:Capn7
uniprot id: Q499T5
names: Similarity
messages: Belongs to the peptidase C2 family.

10116:Cfap126
gene id: 10116:Cfap126
uniprot id: A6JFT6
uniprot id: D3ZCQ6
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the Flattop family.

10116:Acap2
gene id: 10116:Acap2
uniprot id: Q5FVC7
names: Activity Regulation
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).
messages: Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits ACAP2 to membranes. Interacts with MICALL1; the interaction is indirect through RAB35.

10116:Abr
gene id: 10116:Abr
uniprot id: A0A0G2JTR4
uniprot id: A6HGV7
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in brain, including the cortex, hippocampus, cerebellum, and brainstem, as well as the spinal cord (at protein level).
messages: Expression gradually increases from late embryonic (18 dpc) stage until adulthood.
messages: Interacts with DLG4.
messages: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity).
messages: Synapse
messages: The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. The C-terminus is a Rho-GAP domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. The protein has a unique structure having two opposing regulatory activities toward small GTP-binding proteins.
messages: axon
messages: dendritic spine

10116:Cnnm3
gene id: 10116:Cnnm3
uniprot id: A0A8I6A1K3
uniprot id: D4ACK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

10116:Rab3d
gene id: 10116:Rab3d
uniprot id: A6JNV4
uniprot id: Q63942
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Highest levels found in lung.
messages: In fetal glands the majority of the proteins are methylated, whereas in neonatal and adult glands, only 50% are methylated.
messages: Interacts with RIMS1, RIMS2, RPH3A and RPH3AL (By similarity). Interacts with RAB3IP (PubMed:7532276). Interacts with CHM; phosphorylation at Thr-86 disrupts this interaction (By similarity). Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (By similarity).
messages: Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM.
messages: Protein transport. Probably involved in regulated exocytosis (By similarity).
messages: Protein transport. Probably involved in vesicular traffic.

10116:Asph
gene id: 10116:Asph
uniprot id: A0A8I5ZX27
uniprot id: A0A8I5ZX44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

10116:Slc38a10
gene id: 10116:Slc38a10
uniprot id: E9PT23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Facilitates bidirectional transport of amino acids. May act as a glutamate sensor that regulates glutamate-glutamine cycle and mTOR signaling in the brain. The transport mechanism remains to be elucidated.
messages: Membrane
messages: Only expressed in the pituitary, adrenal gland, stomach and in the upper gastrointestinal tract.

10116:Or13j1
gene id: 10116:Or13j1
uniprot id: A6IJ49
uniprot id: D3ZIE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Dpf3
gene id: 10116:Dpf3
uniprot id: A0A8I6AL27
names: Similarity
messages: Belongs to the requiem/DPF family.

10116:Thap1
gene id: 10116:Thap1
uniprot id: A6IVY9
uniprot id: Q5U208
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity).
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter (By similarity).
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: PML body
messages: nucleoplasm

10116:Ggh
gene id: 10116:Ggh
uniprot id: A6IID6
uniprot id: Q62867
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity is altered by insulin and estrogen.
messages: Belongs to the peptidase C26 family.
messages: Homodimer.
messages: Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates (PubMed:8621474, PubMed:8343522). Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Exhibits either endo- or exopeptidase activity depending upon the tissue of origin. When secreted, it acts primarily as an endopeptidase (By similarity).
messages: Lysosome
messages: Melanosome
messages: extracellular space

10116:Eef1g
gene id: 10116:Eef1g
uniprot id: A6HZY2
uniprot id: Q68FR6
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

10116:Mepce
gene id: 10116:Mepce
uniprot id: A6IZZ6
uniprot id: G3V656
uniprot id: Q5I0E0
names: Similarity
messages: Belongs to the methyltransferase superfamily.

10116:Ifnk
gene id: 10116:Ifnk
uniprot id: A6IIP3
uniprot id: D3ZI34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

10116:Napepld
gene id: 10116:Napepld
uniprot id: A0A0G2K5Y7
uniprot id: A6K5B2
uniprot id: Q769K2
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by divalent cations (PubMed:17655883). Activated by bile acids (By similarity). Activated by membrane phospholipids such as phosphatidylethanolamines. Inhibited by cardiolipins (PubMed:17655883).
messages: Belongs to the NAPE-PLD family.
messages: Binds 2 zinc divalent cations per subunit.
messages: D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (PubMed:14634025, PubMed:16527816, PubMed:17655883). Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (By similarity). May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (By similarity).
messages: Early endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.
messages: Nucleus envelope
messages: Widely expressed. Highest expression in brain, kidney and testis (at protein level). Expressed in adipose tissue (at protein level).
messages: nucleoplasm

10116:Vgll4
gene id: 10116:Vgll4
uniprot id: A0A8I6GKS4
uniprot id: A6IKX3
uniprot id: A6IKX5
uniprot id: F7F7Y1
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

10116:Syp
gene id: 10116:Syp
uniprot id: A6KP94
uniprot id: P07825
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Expressed in the brain with expression in the cerebrum and the cerebellum.
messages: Expressed in the spinal cord of newborn animals.
messages: Homohexamer or homotetramer. Interacts with SRCIN1 (By similarity). Interacts with VAMP2; the interaction is inhibit by interaction of VAPM2 with SEPT8 (PubMed:19196426).
messages: Membrane
messages: Phosphorylated by SRC.
messages: Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
messages: The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
messages: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
messages: synaptic vesicle membrane
messages: synaptosome

10116:Thoc7
gene id: 10116:Thoc7
uniprot id: A0A0G2JWV8
uniprot id: A0A0G2K0L6
uniprot id: A6K075
uniprot id: A6K076
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC7 family.
messages: Nucleus
messages: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

10116:Chga
gene id: 10116:Chga
uniprot id: A0A0G2JXJ4
uniprot id: A6JEK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

10116:Gpr162
gene id: 10116:Gpr162
uniprot id: A6ILM5
names: Subcellular Location Annotation
messages: Membrane

10116:Cox7a2
gene id: 10116:Cox7a2
uniprot id: B2RYS0
uniprot id: P35171
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIa family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with PET100.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

10116:Nkx2-2
gene id: 10116:Nkx2-2
uniprot id: D3ZDQ2
names: Subcellular Location Annotation
messages: Nucleus

10116:Mcm4
gene id: 10116:Mcm4
uniprot id: A6JSR9
uniprot id: G3V681
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

10116:Id1
gene id: 10116:Id1
uniprot id: A0A8L2QPI3
uniprot id: A0JPJ2
uniprot id: P41135
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer with other HLH proteins. Interacts with COPS5, IFI204, GATA4, NKX2-5, CLOCK and BMAL1 (By similarity). Isoform Short can form homodimers.
messages: Nucleus
messages: Phosphorylated in vitro by PKA and PKC.
messages: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity).

10116:Myl1
gene id: 10116:Myl1
uniprot id: P02600
names: Function
names: PTM
names: Subunit
messages: Isoform MLC3 is acetylated at position 2.
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains. Does not bind calcium.
messages: Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function.

10116:Skap2
gene id: 10116:Skap2
uniprot id: A6K0P7
uniprot id: Q920G0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SKAP family.
messages: Cytoplasm
messages: Interacts with FYB1, which is required for SKAP2 protein stability. Interacts with PTPNS1. Part of a complex consisting of SKAP2, FYB1 and PTPNS1. Part of a complex consisting of SKAP2, FYB1 and LILRB3. Interacts with LAT, GRB2, PTK2B, and PRAM1. May interact with actin. May interact with FYN, HCK and LYN. Interacts with FASLG (By similarity).
messages: May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway (By similarity).
messages: The SH3 domain interacts with FYB1 and PTK2B.

10116:Cyp2c24
gene id: 10116:Cyp2c24
uniprot id: F1M0F9
names: Similarity
messages: Belongs to the cytochrome P450 family.

10116:Itm2c
gene id: 10116:Itm2c
uniprot id: A6JWF5
uniprot id: Q5PQL7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ITM2 family.
messages: Cell membrane
messages: Interacts with BACE1. Interacts with APP. Interacts with STMN2 (By similarity).
messages: Lysosome membrane
messages: Membrane
messages: Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
messages: Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembrane cleavage by SPPL2B (By similarity).

10116:Lao1
gene id: 10116:Lao1
uniprot id: A6JZK6
uniprot id: F7FCK8
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

10116:Idh3b
gene id: 10116:Idh3b
uniprot id: A6HQ80
uniprot id: Q68FX0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion
messages: Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
messages: The heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits can be allosterically activated by citrate (CIT) or/and ADP, and the two activators can act independently or synergistically. The heterodimer composed of IDH3A and IDH3B subunits cannot be allosterically regulated and the allosteric regulation of the heterotetramer is through the IDH3G subunit and not the IDH3B subunit. The IDH3G subunit contains the allosteric site which consists of a CIT-binding site and an ADP-binding site, and the binding of CIT and ADP causes conformational changes at the allosteric site which are transmitted to the active site in the catalytic subunit (IDH3A) through a cascade of conformational changes at the heterodimer interface, leading to stabilization of the isocitrate-binding at the active site and thus activation of the enzyme. ATP can activate the heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits at low concentrations but inhibits their activities at high concentrations, whereas ATP exhibits only inhibitory effect on the heterodimer composed of IDH3A and IDH3B subunits.

10116:Hgf
gene id: 10116:Hgf
uniprot id: A6K5E8
uniprot id: P17945
names: Caution
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Has lost two of the three essential catalytic residues and so probably has no enzymatic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (By similarity). Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). Activates MAPK signaling following TMPRSS13 cleavage and activation (By similarity).
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
messages: The single-chain precursor undergoes proteolytic processing by TMPRSS13 resulting in an active two-chain form.

10116:Srd5a2
gene id: 10116:Srd5a2
uniprot id: A6H9Z5
uniprot id: P31214
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids (PubMed:1527072). It plays a central role in sexual differentiation and androgen physiology (By similarity).
messages: Endoplasmic reticulum membrane
messages: Expressed in high levels in the prostate and many other androgen-sensitive tissues.
messages: Membrane
messages: Microsome membrane

10116:Sult6b1
gene id: 10116:Sult6b1
uniprot id: M0R952
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

10116:LOC679149
gene id: 10116:LOC679149
uniprot id: Q4QR68
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

10116:Abca12
gene id: 10116:Abca12
uniprot id: D4A7J3
names: Subcellular Location Annotation
messages: Membrane

10116:Sdr9c7
gene id: 10116:Sdr9c7
uniprot id: F1MAS7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

10116:Ercc1
gene id: 10116:Ercc1
uniprot id: A6J8M3
uniprot id: D3ZAQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

10116:Fbln5
gene id: 10116:Fbln5
uniprot id: A6JEJ1
uniprot id: Q9WVH8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fibulin family.
messages: Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN.
messages: Homodimer. Monomer, homodimerizes in presence of Ca(2+). Interacts with ELN. Interacts (via N-terminus) with the integrins ITGAV/ITGB3, ITGAV/ITGB5 and ITGA9/ITGB1. Interacts with FBN1 (via N-terminal domain). Forms a ternary complex with ELN and FBN1. Interacts with EFEMP2 with moderate affinity (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: N-glycosylated.
messages: Secreted
messages: extracellular matrix

10116:Lsm2
gene id: 10116:Lsm2
uniprot id: A0A0G2K8Q7
uniprot id: A6KTP6
uniprot id: A6KTP7
uniprot id: M0R7N1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

10116:Vom2r26
gene id: 10116:Vom2r26
uniprot id: A0A8I6A0Z9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Mtmr3
gene id: 10116:Mtmr3
uniprot id: A0A8I6AAN8
uniprot id: Q5PQT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane
messages: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity).

10116:Or12j5
gene id: 10116:Or12j5
uniprot id: A6HXI8
uniprot id: D4A7A7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Shank1
gene id: 10116:Shank1
uniprot id: Q9WV48
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SHANK family.
messages: Cytoplasm
messages: Expressed only in brain (neuropil of cortex, CA1 region hippocampus and molecular layer of cerebellum).
messages: Expression increases from low levels at birth to high levels at 3-4 weeks before dropping slightly in adulthood. Expressed in the cortex and the molecular layer of the cerebellum at postnatal day 7. Isoform 2 expression does not change during development of both cortex and cerebellum. Isoform 4 expression decreases significantly during development of cortex but not cerebellum.
messages: May homomultimerize via its SAM domain. Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with SHARPIN, SPTAN1 and DLGAP1/GKAP. Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with BAIAP2 (By similarity). Interacts with IGSF9. Interacts with HOMER1 and HOMER3 (PubMed:19345194).
messages: Postsynaptic density
messages: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.
messages: Synapse

10116:Tspyl4
gene id: 10116:Tspyl4
uniprot id: F7EPM0
uniprot id: Q66H46
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

10116:Hmgb1
gene id: 10116:Hmgb1
uniprot id: B4F758
uniprot id: P63159
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on multiple sites upon stimulation with LPS (By similarity). Acetylation on lysine residues in the nuclear localization signals (NLS 1 and NLS 2) leads to cytoplasmic localization and subsequent secretion (PubMed:14532127). Acetylation on Lys-3 results in preferential binding to DNA ends and impairs DNA bending activity (PubMed:17269659).
messages: Belongs to the HMGB family.
messages: Cell membrane
messages: Chromosome
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Endosome
messages: Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers.
messages: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (By similarity). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity).
messages: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22869893). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (By similarity). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:10952726, PubMed:20547845, PubMed:22869893). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12. TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (By similarity). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:23508573). Contributes to tumor proliferation by association with ACER/RAGE (PubMed:10830965). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (By similarity). Binding to class A CpG activates cytokine production in plas…
messages: In vitro cleavage by CASP1 is liberating a HMG box 1-containing peptide which may mediate immunogenic activity; the peptide antagonizes apoptosis-induced immune tolerance. Can be proteolytically cleaved by a thrombin:thrombomodulin complex; reduces binding to heparin and pro-inflammatory activities (By similarity).
messages: Interacts (fully reduced HMGB1) with CXCL12; probably in a 1:2 ratio involving two molecules of CXCL12, each interacting with one HMG box of HMGB1; inhibited by glycyrrhizin (PubMed:22869893). Associates with the TLR4:LY96 receptor complex (PubMed:20547845). Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2 (By similarity). Interacts (in cytoplasm upon starvation) with BECN1; inhibits the interaction of BECN1 and BCL2 leading to promotion of autophagy (PubMed:20819940). Interacts with KPNA1; involved in nuclear import (By similarity). Interacts with AGER (PubMed:12183440). Interacts with PTPRZ1 isoform 3/phosphacan (PubMed:9507007). Interacts with SREBF1, TLR2, TLR4, TLR9, APEX1, FEN1, POLB, TERT, IL1B, MSH2, XPA, XPC, HNF1A, TP53 (By similarity). Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response. Interacts with THBD; prevents HGMB1 interaction with ACER/RAGE and inhibits HGMB1 pro-inflammatory activity. Interacts with HAVCR2; impairs HMGB1 binding to B-DNA and likely HMGB1-mediated innate immune response (By similarity). Interacts with XPO1; mediating nuclear export (PubMed:14532127). Interacts with receptor RAGE/AGER (By similarity).
messages: Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide (PubMed:11154118). Bound to RAGE mediates signaling for neuronal outgrowth (PubMed:1885601, PubMed:2461949, PubMed:7592757, PubMed:12183440). May play a role in accumulation of expanded polyglutamine (polyQ) proteins.
messages: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA (PubMed:2922595, PubMed:11513603). Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:12486007). May be involved in nucleotide excision repair (NER), mismatch repair (MMR) and base excision repair (BER) pathways, and double strand break repair such as non-homologous end joining (NHEJ) (PubMed:10866811). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (PubMed:24551219). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (By similarity). May be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1 (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity).
messages: Nucleus
messages: Phosphorylated at serine residues. Phosphorylation in both NLS regions is required for cytoplasmic translocation followed by secretion.
messages: Poly-ADP-ribosylated by PARP1 when secreted following stimulation with LPS.
messages: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB1 (HMGB1C23hC45hC106h), 2- disulfide HMGB1 (HMGB1C23-C45C106h) and 3- sulfonyl HMGB1 (HMGB1C23soC45soC106so).
messages: Secreted
messages: The acidic C-terminal domain forms a flexible structure which can reversibly interact intramolecularily with the HMG boxes and modulate binding to DNA and other proteins.
messages: Was reported that reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities. However, this work was later retracted, although the roles of different redox forms in some functional activities is supported by other papers.

10116:Or6ae1
gene id: 10116:Or6ae1
uniprot id: A6HXH8
uniprot id: D3ZUL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ptgs2
gene id: 10116:Ptgs2
uniprot id: A6ICR0
uniprot id: P35355
names: Caution
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated at Ser-565 by SPHK1. During neuroinflammation, acetylation by SPHK1 promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia.
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: By cytokines and mitogens.
messages: Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PTGS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PTGS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation.
messages: Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Similarly catalyzes successive cyclooxygenation and peroxidation of dihomo-gamma-linoleate (DGLA, C20:3(n-6)) and eicosapentaenoate (EPA, C20:5(n-3)) to corresponding PGH1 and PGH3, the precursors of 1- and 3-series prostaglandins. In an alternative pathway of prostanoid biosynthesis, converts 2-arachidonoyl lysophopholipids to prostanoid lysophopholipids, which are then hydrolyzed by intracellular phospholipases to release free prostanoids. Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response. Generates lipid mediators from n-3 and n-6 polyunsaturated fatty acids (PUFAs) via a lipoxygenase-type mechanism. Oxygenates PUFAs to hydroperoxy compounds and then reduces them to corresponding alcohols. Plays a role in the generation of resolution phase interaction products (resolvins) during both sterile and infectious inflammation. Metabolizes docosahexaenoate (DHA, C22:6(n-3)) to 17R-HDHA, a precursor of the D-series resolvins (RvDs). As a component of the biosynthetic pathway of E-series resolvins (RvEs), converts eicosapentaenoate (EPA, C20:5(…
messages: Endoplasmic reticulum membrane
messages: Expressed throughout the forebrain in discrete populations of neurons and is enriched in the cortex and hippocampus.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Microsome membrane
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimer's disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration.
messages: S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-526.
messages: The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site.

10116:Crhbp
gene id: 10116:Crhbp
uniprot id: F7EU31
uniprot id: O35761
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRF-binding protein family.
messages: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
messages: Secreted

10116:Epc2
gene id: 10116:Epc2
uniprot id: A0A8I5ZZ28
uniprot id: A6JEZ5
uniprot id: D4ADG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

10116:Hapln1
gene id: 10116:Hapln1
uniprot id: A1A5N6
uniprot id: P03994
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAPLN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
messages: extracellular matrix

10116:Msn
gene id: 10116:Msn
uniprot id: O35763
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding.
messages: Apical cell membrane
messages: Cell membrane
messages: Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement. These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction. The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (By similarity). Modulates phagolysosomal biogenesis in macrophages (By similarity). Participates also in immunologic synapse formation (By similarity).
messages: In resting T-cells, part of a PAG1-NHERF1-MSN complex which is disrupted upon TCR activation. Interacts with NHERF1. Interacts with PPP1R16B. Interacts with PDZD8. Interacts with SELPLG and SYK; these interactions mediate the activation of SYK by SELPLG. Interacts with PDPN (via cytoplasmic domain); this interaction activates RHOA and promotes epithelial-mesenchymal transition. Interacts with SPN/CD43 cytoplasmic tail (By similarity). Interacts with CD44 (By similarity). Interacts with ICAM2 (By similarity). Interacts with ICAM3 (via C-terminus). Interacts with PDZD8. Interacts with F-actin. Interacts with CD46 (By similarity). Interacts with PTPN6 (By similarity).
messages: Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding. Phosphorylation on Thr-558 by STK10 negatively regulates lymphocyte migration and polarization (By similarity).
messages: S-nitrosylation of Cys-117 is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) implicating the iNOS-S100A8/9 transnitrosylase complex.
messages: The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
messages: cytoskeleton
messages: microvillus
messages: microvillus membrane

10116:Zw10
gene id: 10116:Zw10
uniprot id: A6J4B1
uniprot id: Q4V8C2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZW10 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (By similarity).
messages: Interacts with NBAS and KNTC1/ROD; the interactions are mutually exclusive and indicative for its association in two different vesicle tethering complexes (By similarity). Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH (By similarity). Component of the NRZ complex composed of NBAS, ZW10 and RINT1/TIP20L; NRZ associates with SNAREs STX18, USE1L, BNIP1/SEC20L and SEC22B (the assembly has been described as syntaxin 18 complex) (By similarity). Interacts directly with RINT1/TIP20L bound to BNIP1/SEC20L (By similarity). Interacts with C19orf25 and ZWINT (By similarity). Interacts with ZFYVE1 (By similarity). Interacts with RAB18 and this interaction is enhanced in the presence of ZFYVE1 (By similarity).
messages: Lipid droplet
messages: kinetochore
messages: spindle

10116:Nipal4
gene id: 10116:Nipal4
uniprot id: A6HDR0
uniprot id: D3ZA72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

10116:Pik3c2a
gene id: 10116:Pik3c2a
uniprot id: A6I8E5
uniprot id: D3ZTF6
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

10116:Stxbp2
gene id: 10116:Stxbp2
uniprot id: Q62753
names: Function
names: Similarity
names: Subunit
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Interacts with STX1A, STX2 and STX3. Interacts with STX11.
messages: Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells (By similarity).

10116:Prickle2
gene id: 10116:Prickle2
uniprot id: A6IBC5
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

10116:Adamts13
gene id: 10116:Adamts13
uniprot id: D4A0T9
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

10116:Slc25a16
gene id: 10116:Slc25a16
uniprot id: A0A9K3Y7D2
uniprot id: B2GV20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

10116:Cfap107
gene id: 10116:Cfap107
uniprot id: A6IU06
names: Function
names: Subcellular Location Annotation
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
messages: cilium axoneme

10116:Atp11a
gene id: 10116:Atp11a
uniprot id: D4A7K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

10116:Pgls
gene id: 10116:Pgls
uniprot id: A6K9W6
uniprot id: G3V8D5
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

10116:Npy2r
gene id: 10116:Npy2r
uniprot id: Q9ERC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Epgn
gene id: 10116:Epgn
uniprot id: A6KKD1
uniprot id: D3Z9P6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Slc5a12
gene id: 10116:Slc5a12
uniprot id: A6HP16
uniprot id: F1LWL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

10116:Shq1
gene id: 10116:Shq1
uniprot id: B4F784
names: Similarity
messages: Belongs to the SHQ1 family.

10116:Bnip3l
gene id: 10116:Bnip3l
uniprot id: A0A8I6AKI3
uniprot id: A6K6N6
uniprot id: Q8VBW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

10116:Senp8
gene id: 10116:Senp8
uniprot id: A6J539
uniprot id: Q5FVJ8
names: Function
names: Similarity
messages: Belongs to the peptidase C48 family.
messages: Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.

10116:Slco5a1
gene id: 10116:Slco5a1
uniprot id: A6JFD8
uniprot id: D3ZZM7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Olr947
gene id: 10116:Olr947
uniprot id: D3ZQZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Smdt1
gene id: 10116:Smdt1
uniprot id: A0A8I6ASM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

10116:Lyrm1
gene id: 10116:Lyrm1
uniprot id: A6I8P6
names: Similarity
messages: Belongs to the complex I LYR family.

10116:Fundc1
gene id: 10116:Fundc1
uniprot id: A6JZV7
uniprot id: Q5BJS4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
messages: Belongs to the FUN14 family.
messages: Interacts (via YXXL motif) with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP.
messages: Mitochondrion outer membrane
messages: Phosphorylation at Tyr-18 by SRC inhibits activation of mitophagy. Following hypoxia, dephosphorylated at Tyr-18, leading to interaction with MAP1 LC3 family proteins and triggering mitophagy (By similarity).
messages: The YXXL motif mediates the interaction with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP.

10116:Olr1334
gene id: 10116:Olr1334
uniprot id: A0A0G2K2S6
uniprot id: A6J3P0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Fcgr2b
gene id: 10116:Fcgr2b
uniprot id: Q63203
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens.
messages: Cell membrane
messages: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
messages: Interacts with FGR and LYN.
messages: Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK.

10116:Dusp9
gene id: 10116:Dusp9
uniprot id: A0A0G2JYH3
uniprot id: Q2YDV1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

10116:Cyp4f1
gene id: 10116:Cyp4f1
uniprot id: A6K970
uniprot id: F7F3E1
names: Similarity
messages: Belongs to the cytochrome P450 family.

10116:Stx8
gene id: 10116:Stx8
uniprot id: Q9Z2Q7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the syntaxin family.
messages: Membrane
messages: Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8. Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes. Interacts with HECTD3 (By similarity). Interacts with TPC1 (By similarity).
messages: Ubiquitinated by HECTD3.
messages: Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.
messages: Widely expressed in all tissues examined.

10116:Cmklr1
gene id: 10116:Cmklr1
uniprot id: O35786
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: High expression in heart and lung, low in small intestines, colon, kidney, liver, uterus and brain.
messages: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity).

10116:Myo1b
gene id: 10116:Myo1b
uniprot id: Q05096
names: Caution
names: Function
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.
messages: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).

10116:Homer1
gene id: 10116:Homer1
uniprot id: A6I4T1
uniprot id: A6I4T3
uniprot id: Q9Z214
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Highly expressed in cortex, Purkinje cells of the cerebellum, hippocampus, striatum and olfactory bulb. Isoform 1 and isoform 3 are expressed in skeletal and cardiac muscle.
messages: In the developing hippocampus, the expression of isoform 1 is high at P8, then decreased with progression of hippocampal development. Isoform 3 expression was constitutively low, and not regulated during hippocampal development.
messages: Induced in the hippocampus, by seizure and synaptic mechanisms in association with long-term potentiation (LTP). It is also induced in the striatum by drugs that alter dopamine signaling.
messages: Postsynaptic density
messages: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 3 counteracts the effects by competing for binding sites. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, and isoform 2 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (PubMed:19345194). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity).
messages: Synapse
messages: Tetramer; this tetrameric structure is critical for forming the high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (PubMed:19345194). Interacts with GRM1, GRM5, ITPR1, DYN3, RYR1, RYR2 and SHANK3 (PubMed:10433269, PubMed:10798399, PubMed:12810060, PubMed:12887973, PubMed:9069287, PubMed:9808458, PubMed:9808459, PubMed:9727012). Interacts with IFT57 and OPHN1 (PubMed:15034583). Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization. Interacts with SHANK1; forms high-order polymerized complex with a mesh-like network structure, at least composed of SHANK1, HOMER1 and DLGAP1; the complex formation is SHANK1 multimerization dependent (PubMed:10433269, PubMed:19345194). Interacts with NFATC4 (By similarity). Interacts with DAGLA (via PPXXF motif); this interaction is required for the cell membrane localization of DAGLA (PubMed:17584991). Interacts with SRGAP2 (By similarity).
messages: The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3. The coiled-Coil domain forms an antiparallel tetrameric arrangement (PubMed:19345194).
messages: dendritic spine

10116:Kyat1
gene id: 10116:Kyat1
uniprot id: Q08415
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:7796908, PubMed:6783036, PubMed:2072101). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:8502223).
messages: Detected in kidney.
messages: Homodimer.
messages: Inhibited by aminooxyacetate (in vitro).
messages: Mitochondrion matrix
messages: cytosol

10116:Tmem147
gene id: 10116:Tmem147
uniprot id: A6JA11
uniprot id: Q2TA63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM147 family.
messages: Cell membrane
messages: Component of the back of Sec61 (BOS) complex, composed of NCLN/Nicalin, NOMO (NOMO1, NOMO2 or NOMO3) and TMEM147. The BOS complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47). The MPT complex associates with the SEC61 complex. Interacts with CHRM3, CHRM1 and AVPR2. Interacts with LBR; promoting LBR localization to the nucleus inner membrane. Interacts with DHCR7.
messages: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Regulates LBR localization to the nucleus inner membrane.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane

10116:Cdhr5
gene id: 10116:Cdhr5
uniprot id: Q9JIK1
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: At embryonic day 19, both maternal and embryonic kidneys express isoform 1 almost exclusively. In the postpartum female and neonate, expression of isoform 2 increases.
messages: Expressed predominantly in kidney. Also detected in lung and small intestine.
messages: Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation.
messages: N- and O-glycosylated.
messages: Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5. Interacts (via cytoplasmic domain) with USH1C and MYO7B; required for proper localization of CDHR5 to microvilli tips and its function in brush border differentiation.
messages: microvillus membrane

10116:Kcnd2
gene id: 10116:Kcnd2
uniprot id: A0A8I6GL23
uniprot id: A6IE48
uniprot id: Q63881
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Detected in brain cortex, hippocampus, dentate gyrus, thalamus and cerebellum (PubMed:16123112). Detected in neurons from the primary visual cortex (PubMed:16207878). Detected in the supraoptic nucleus in hypothalamus, in hippocampus and the habenular nucleus of the thalamus (PubMed:9070739). Detected in the bed nucleus of the stria terminalis (PubMed:24037673). Detected in dendritic fields in the hippocampus CA1 layer, in stratum radiatum, stratum oriens, stratum lacunosum-moleculare and stratum pyramidale (PubMed:10676964, PubMed:22098631). Detected in dendritic fields in the hippocampus CA3 layer and in dentate gyrus (PubMed:10676964). Detected in the cerebellum granule cell layer, where it localizes at synapses (PubMed:11102480, PubMed:10676964, PubMed:15736227). Detected in the main olfactory bulb, especially in the granule cell layer and the external plexiform layer, but also the mitral layer (PubMed:18371079). Detected in heart atrium and ventricle (PubMed:10860776). Detected in heart left ventricle (at protein level) (PubMed:24793047). Highly expressed in heart and throughout the brain, with similar levels in cortex and hypothalamus, and much higher levels in hippocampus, dentate gyrus and the habenular nucleus of the thalamus. Detected in brain, and at lower levels in heart atrium and ventricle (PubMed:1705709). Detected in neurons from the bed nucleus of the stria terminalis (PubMed:24037673). Detected in aorta, cardiac and smooth muscle.
messages: Down-regulated in response to hypoxia lasting about 15 min, a treatment that leads to spontaneous convulsive seizures in these pups.
messages: Homotetramer or heterotetramer with KCND1 or KCND3 (PubMed:12754210, PubMed:15485870, PubMed:20224290, PubMed:25352783). Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4 (PubMed:10676964, PubMed:12451113, PubMed:11847232, PubMed:11805342, PubMed:15485870, PubMed:15356203, PubMed:15452711, PubMed:16820361, PubMed:20045463, PubMed:24811166, PubMed:14980206). Interacts with DPP6, DPP10, DLG4 and DLG1 (PubMed:11923279, PubMed:12575952, PubMed:14559911, PubMed:15671030, PubMed:19213956). In vivo, probably exists as heteromeric complex containing variable proportions of KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (PubMed:16123112, PubMed:19901547). The tetrameric channel can associate with up to four regulatory subunits, such as KCNIP2 or KCNIP4 (By similarity). Interaction with KCNIP3 promotes tetramerization and formation of a functional potassium channel (PubMed:15485870). Interaction with four KCNIP4 chains does not reduce interaction with DPP10 (By similarity). Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2 (By similarity). Interacts with FLNA and FLNC (PubMed:11102480). Interacts with NCS1/FREQ (By similarity). Identified in a complex with cAMP-dependent protein kinase (PKA), CAV3, AKAP6 and KCND3 in cardiac myocytes (PubMed:20224290).
messages: Inhibited by 5 mM 4-aminopyridine (4-AP) (PubMed:1840649, PubMed:1722463, PubMed:9093524). Not inhibited by dendrotoxins and by tetraethylammonium (TEA) (PubMed:1722463). Inhibited by 10 mM flecainide and 20 mM quinidine (PubMed:9093524). Inhibited by the heteropodatoxins HpTx(1), HpTx(2), and HpTx(3) (PubMed:9058605).
messages: Is specifically and reversibly inhibited by the scorpion toxin Ts8 (AC P69940).
messages: Membrane
messages: Perikaryon
messages: Phosphorylation at Ser-438 in response to MAPK activation is increased in stimulated dendrites (PubMed:24404150). Interaction with KCNIP2 and DPP6 propomtes phosphorylation by PKA at Ser-552 (PubMed:19441798). Phosphorylation at Ser-552 has no effect on interaction with KCNIP3, but is required for the regulation of channel activity by KCNIP3 (PubMed:12451113). Phosphorylation at Ser-552 leads to KCND2 internalization (PubMed:17582333). Phosphorylated by MAPK in response to signaling via the metabotropic glutamate receptor GRM5 (By similarity). Phosphorylation at Ser-616 is required for the down-regulation of neuronal A-type currents in response to signaling via GRM5 (By similarity).
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: The C-terminal cytoplasmic region is important for normal expression at the cell membrane and modulates the voltage-dependence of channel activation and inactivation. It is required for interaction with KCNIP2, and probably other family members as well.
messages: The N-terminal cytoplasmic region can mediate N-type inactivation by physically blocking the channel (PubMed:15452711). This probably does not happen in vivo, where the N-terminal region mediates interaction with regulatory subunits, such as KCNIP1 and KCNIP2 (PubMed:16820361, PubMed:18357523, PubMed:14980206). The zinc binding sites in the N-terminal domain are important for tetramerization and assembly of a functional channel complex (PubMed:12754210). Most likely, the channel undergoes closed-state inactivation, where a subtle conformation change would render the protein less sensitive to activation.
messages: The transient neuronal A-type potassium current called I(SA) is triggered at membrane potentials that are below the threshold for action potentials. It inactivates rapidly and recovers rapidly from inactivation. It regulates the firing of action potentials and plays a role in synaptic integration and plasticity. Potassium channels containing KCND2 account for about 80% of the neuronal A-type potassium current. In contrast, the potassium channel responsible for the cardiac I(to) current differs between species; it is mediated by KCND2 in rodents. In human and other non-rodents KCND3 may play an equivalent role.
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
messages: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in rodent heart (PubMed:1840649, PubMed:1722463, PubMed:9093524, PubMed:9058605, PubMed:10676964, PubMed:12592409, PubMed:12754210, PubMed:16207878, PubMed:16123112, PubMed:19279261, PubMed:25352783, PubMed:14980206). Mediates the major part of the dendritic A-type current I(SA) in brain neurons (PubMed:16207878, PubMed:17026528). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member (PubMed:9093524, PubMed:9058605). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:1840649, PubMed:1722463, PubMed:9093524, PubMed:10676964, PubMed:12451113, PubMed:12592409, PubMed:12754210, PubMed:15452711, PubMed:16207878, PubMed:16820361, PubMed:25352783, PubMed:14980206). Can form functional homotetrameric channels and heterotetrameric channels that cont…
messages: caveola
messages: dendrite
messages: dendritic spine
messages: sarcolemma

10116:Ces1e
gene id: 10116:Ces1e
uniprot id: A0A8I6AA76
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

10116:Nrf1
gene id: 10116:Nrf1
uniprot id: A6IEF2
uniprot id: A6IEF3
uniprot id: F7FCI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRF1/Ewg family.
messages: Nucleus

10116:Ubl4a
gene id: 10116:Ubl4a
uniprot id: B2GV38
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
messages: Component of the BAG6/BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35. Interacts with BAG6; the interaction is direct and required for UBL4A protein stability. Interacts with USP13; may be indirect via BAG6.
messages: Nucleus
messages: Polyubiquitinated. Ubiquitination by AMFR and deubiquitination by USP13 may regulate the interaction between the BAG6/BAT complex and SGTA and therefore may regulate client proteins fate.
messages: cytosol

10116:Taf9
gene id: 10116:Taf9
uniprot id: A6I598
uniprot id: Q5BKE0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: AK6 and TAF9 were initially considered as products of the same gene since they share two exons. However, they are translated from different initiation codons and reading frames and encode unrelated proteins. This arrangement is conserved in some mammalian species.
messages: Belongs to the TAF9 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. The PCAF complex consists at least of TADA2L/ADA2, SUPT3H/SPT3, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. The STAGA transcription coactivator-HAT complex consists at least of SUPT3H, GCN5L2, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Binds N-terminal domain of p53/TP53 which is essential for transcription. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Binds TFIIB and the Herpes simplex virus activator VP16. Forms a heterodimer with TAF6 in a complex with the TAF4B-TAF12 heterodimer. Also interacts with TAF5. Binds directly DNA. Increased DNA binding when complexed with TAF6.
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF9 is also a component of the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TAF9 and its paralog TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. Essential for cell viability. May have a role in gene regulation associated with apoptosis.

10116:Gpr180
gene id: 10116:Gpr180
uniprot id: G3V799
names: Subcellular Location Annotation
messages: Membrane

10116:Psmd13
gene id: 10116:Psmd13
uniprot id: B0BN93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S11 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

10116:Dzip1
gene id: 10116:Dzip1
uniprot id: A0A8I5ZVC1
uniprot id: A0A8I6A380
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: cilium basal body

10116:Ftl1
gene id: 10116:Ftl1
uniprot id: A6JB33
uniprot id: P02793
names: Domain
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the ferritin family.
messages: In rat liver, the light chain is the major chain.
messages: Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
messages: The rat light chain has an octopeptide insertion after residue 158 compared with other light chains.

10116:Tigd3
gene id: 10116:Tigd3
uniprot id: A6HZA9
uniprot id: D3ZS21
names: Subcellular Location Annotation
messages: Nucleus

10116:Slc5a6
gene id: 10116:Slc5a6
uniprot id: B4F760
uniprot id: O70247
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Expressed in the jejunum (at protein level) (PubMed:12620923). Expressed in lung, skeletal muscle, heart, brain, kidney, intestine, liver, and placenta (PubMed:9516450, PubMed:12620923).
messages: Expressed in the jejunum in 13-14 days old animals (at protein level) (PubMed:12620923). Expressed in the kidney in 13-14 days old animals (PubMed:12620923).
messages: Interacts with PDZD11.
messages: Membrane
messages: Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide (PubMed:9516450). Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake. Required for biotin and pantothenate uptake in the intestine across the brush border membrane (By similarity). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier (By similarity).
messages: The C-terminal tail is important for biotin uptake as well as apical localization in polarized cells.

10116:Gpr37l1
gene id: 10116:Gpr37l1
uniprot id: A6ICE3
uniprot id: A6ICE4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Acadl
gene id: 10116:Acadl
uniprot id: A6KFD6
uniprot id: P15650
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-318 and Lys-322 in proximity of the cofactor-binding sites strongly reduces catalytic activity. These sites are deacetylated by SIRT3.
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Inhibited by crotonyl-CoA, 2-octenoyl-CoA and 2-hexadecenoyl-CoA.
messages: Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:3968063). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:3968063). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains (PubMed:3968063, PubMed:15466478).
messages: Mitochondrion matrix

10116:Retnlg
gene id: 10116:Retnlg
uniprot id: G3V686
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the resistin/FIZZ family.
messages: Highly expressed in bone marrow, spleen and white blood cells. Also detected at low levels in thymus, lung, trachea, white adipose tissue, nasal respiratory epithelium, colon, small intestine, kidney, liver, and heart.
messages: Homodimer. Heterodimer with RETNLB.
messages: Probable hormone (Probable). Promotes chemotaxis in myeloid cells (By similarity).
messages: Secreted

10116:Mboat1
gene id: 10116:Mboat1
uniprot id: A6J7M5
uniprot id: F1LV18
names: Subcellular Location Annotation
messages: Membrane

10116:Tnfrsf1a
gene id: 10116:Tnfrsf1a
uniprot id: A0A8I6GJG3
uniprot id: P22934
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BABAM2, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with DAB2IP. Interacts directly with NOL3 (via CARD domain); inhibits TNF-signaling pathway. Interacts with SH3RF2, TRADD and RIPK1. SH3RF2 facilitates the recruitment of RIPK1 and TRADD to TNFRSF1A in a TNF-alpha-dependent process. Interacts with PGLYRP1; this interaction is important for cell death induction. Interacts (via death domain) with MADD (via death domain) (By similarity).
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity).

10116:Smad7
gene id: 10116:Smad7
uniprot id: A0A0G2JSQ5
uniprot id: O88406
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylation prevents ubiquitination and degradation mediated by SMURF1.
messages: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Interacts with COPS5. Interacts with STAMBP. Interacts with NEDD4L. Interacts with RNF111, AXIN1 and AXIN2. Interacts with PPP1R15A. Interacts with ACVR1B, SMURF1, SMURF2 and TGFBR1; SMAD7 recruits SMURF1 and SMURF2 to the TGF-beta receptor and regulates its degradation. Interacts with WWP1 (By similarity). Interacts with PDPK1 (via PH domain) (By similarity). Interacts with TSC22D1/TSC-22; the interaction requires TGF-beta and the interaction is inhibited by TGFBR1 (By similarity).
messages: Nucleus
messages: Phosphorylation on Ser-249 does not affect its stability, nuclear localization or inhibitory function in TGFB signaling; however it affects its ability to regulate transcription (By similarity). Phosphorylated by PDPK1 (By similarity).
messages: Ubiquitinated by WWP1 (By similarity). Polyubiquitinated by RNF111, which is enhanced by AXIN1 and promotes proteasomal degradation. In response to TGF-beta, ubiquitinated by SMURF1; which promotes its degradation (By similarity).
messages: Ubiquitous.

10116:Ngb
gene id: 10116:Ngb
uniprot id: Q99JA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes (By similarity).
messages: Monomer. Homodimer and homotetramer; disulfide-linked.
messages: Perikaryon
messages: Widely distributed throughout the adult brain, including cerebral cortex, hippocampus, thalamus, hypothalamus, olfactory bulb, and cerebellum.

10116:Nol10
gene id: 10116:Nol10
uniprot id: Q66H99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

10116:Or52ae8b
gene id: 10116:Or52ae8b
uniprot id: D3ZV48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Rpl29
gene id: 10116:Rpl29
uniprot id: A6I2R0
uniprot id: P25886
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL29 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

10116:Slco1a6
gene id: 10116:Slco1a6
uniprot id: A6IMS9
uniprot id: Q9QYE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May mediate the Na(+)-independent transport of organic anions.
messages: Membrane

10116:Gsta1
gene id: 10116:Gsta1
uniprot id: B6DYP8
uniprot id: P04904
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Alpha family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively (By similarity). Has substantial activity toward aflatoxin B1-8,9-epoxide (By similarity).
messages: Cytoplasm
messages: Heterodimer of YC1 and YC2.
messages: Liver from adult female rats contains about 2-fold greater levels of YC1 than is found in liver from adult male rats.

10116:Mrpl41
gene id: 10116:Mrpl41
uniprot id: A6JSZ9
uniprot id: Q5BJX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with BCL2 (By similarity). Was also identified in the 28S mitochondrial ribosome (PubMed:9857009).
messages: Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
messages: Mitochondrion

10116:Opalin
gene id: 10116:Opalin
uniprot id: Q56A26
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
messages: Membrane

10116:Vom1r93
gene id: 10116:Vom1r93
uniprot id: A6IB68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior.

10116:Hacd1
gene id: 10116:Hacd1
uniprot id: A1IVX5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Rad1
gene id: 10116:Rad1
uniprot id: A6KJS9
uniprot id: D3ZC52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

10116:LOC361346
gene id: 10116:LOC361346
uniprot id: Q66H35
names: Function
names: Subcellular Location Annotation
messages: Might play a role in cell proliferation.
messages: Secreted

10116:LOC100360200
gene id: 10116:LOC100360200
uniprot id: A0A8I6A9L9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

10116:Slc6a7
gene id: 10116:Slc6a7
uniprot id: A0A0G2JYB6
uniprot id: A6IXF3
uniprot id: P28573
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A7 subfamily.
messages: Brain specific sodium (and chloride)-dependent proline transporter (PubMed:10414958). Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals (Probable).
messages: Expressed in subpopulations of putative glutamatergic pathways of rat brain.
messages: Membrane
messages: Synaptic cell membrane

10116:Dohh
gene id: 10116:Dohh
uniprot id: Q5PPJ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.

10116:Fzd10
gene id: 10116:Fzd10
uniprot id: A0A8I5ZWS0
uniprot id: A6J0T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

10116:Ina
gene id: 10116:Ina
uniprot id: A6JHP2
uniprot id: G3V8Q2
names: Similarity
messages: Belongs to the intermediate filament family.

10116:Car14
gene id: 10116:Car14
uniprot id: A2IBE0
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

10116:Yipf3
gene id: 10116:Yipf3
uniprot id: Q6TUD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YIP1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with YIPF4 and YIPF5.
messages: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis (By similarity).
messages: cis-Golgi network membrane

10116:LOC690821
gene id: 10116:LOC690821
uniprot id: A6JNH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Rps21
gene id: 10116:Rps21
uniprot id: A6KMA7
uniprot id: P05765
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

10116:Or10j7
gene id: 10116:Or10j7
uniprot id: A6JG76
uniprot id: D4A178
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Tmem140
gene id: 10116:Tmem140
uniprot id: Q5M826
names: Subcellular Location Annotation
messages: Membrane

10116:Bex4
gene id: 10116:Bex4
uniprot id: A6KT26
uniprot id: Q3MKP9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BEX family.
messages: Cytoplasm
messages: Interacts with alpha-tubulin. Interacts with SIRT2.
messages: May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity).
messages: Nucleus
messages: Ubiquitinated and degraded by the proteasome.
messages: spindle pole

10116:Nmrk1
gene id: 10116:Nmrk1
uniprot id: Q6AY91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the uridine kinase family. NRK subfamily.
messages: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN).
messages: Monomer.

10116:Plxna1
gene id: 10116:Plxna1
uniprot id: A6IB60
uniprot id: D3Z981
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Sdhaf2
gene id: 10116:Sdhaf2
uniprot id: A6I035
uniprot id: Q5RJQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDHA within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

10116:Slc16a1
gene id: 10116:Slc16a1
uniprot id: A6K3P1
uniprot id: P53987
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Bidirectional proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH. The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (PubMed:9374487, PubMed:9639576, PubMed:10417314, PubMed:19473976, PubMed:8526936, PubMed:10564700, PubMed:11719518, PubMed:17127621). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart. Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 302-Asp is essential for the conformational transition (By similarity).
messages: Cell membrane
messages: Detected in erythrocytes (at protein level). Detected in brain, heart, kidney, lung, muscle, jejunum enterocytes and brain capillaries.
messages: Inhibited by stilbene disulfonates, such as di-isothiocyanostilbene disulfonate(DIDS), a cross-linking reagent that forms covalent linkages with lysine groups.
messages: Interacts with BSG. Interacts with EMB. Interaction with either BSG or EMB is required for expression at the cell membrane.
messages: Lateral cell membrane
messages: Membrane

10116:Abcb10
gene id: 10116:Abcb10
uniprot id: Q5FVL8
names: Subcellular Location Annotation
messages: Membrane

10116:Wipf1
gene id: 10116:Wipf1
uniprot id: Q6IN36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the verprolin family.
messages: Binds to WAS within the N-terminal region, at a site distinct from the CDC42-binding site. Binds profilin and actin. Interacts with DBNL (By similarity). Binds to WASL. Interacts with DBNL. Interacts with FNBP1L (via the SH3 domain) (By similarity).
messages: Cytoplasmic vesicle
messages: Isoforms were differentially expressed. One isoform was ubiquitously expressed, another was muscle-specific and another was expressed in the liver, heart and testis.
messages: Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. Plays a role in the formation of cell ruffles (By similarity). May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation.
messages: cytoskeleton
messages: ruffle

10116:Gap43
gene id: 10116:Gap43
uniprot id: A6IR38
uniprot id: P07936
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the neuromodulin family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in hippocampal neurons, with highest levels of expression in the CA4 and CA3 neurons and lower levels in CA1 neurons (PubMed:11948657, PubMed:17577668). Expressed in the dorsal root ganglion (PubMed:12957493).
messages: Expression in dentate granule cells of the hippocampus at postnatal day P5, with disappearing expression in dentate granule cells as early as P14.
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By similarity). Interacts (via IQ domain) with calmodulin (By similarity). Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By similarity).
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Membrane
messages: Palmitoylated by ZDHHC3 (By similarity). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2 (By similarity).
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Perikaryon
messages: Phosphorylated (PubMed:1533624, PubMed:8454596, Ref.13). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (PubMed:1533624, PubMed:8454596, Ref.13).
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: Up-regulated by kainic acid-induced seizures (PubMed:17577668). Up-regulated after axotomy (PubMed:12957493).
messages: axon
messages: dendrite
messages: filopodium membrane
messages: growth cone
messages: growth cone membrane

10116:Ptger1
gene id: 10116:Ptger1
uniprot id: P70597
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Highly abundant in kidney and lung. Found in a lesser extent in spleen, colon, and thymus. Also expressed in uterine myometrium and endometrium.
messages: Phosphorylated.
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function (By similarity). Implicated the smooth muscle contractile response to PGE2 in various tissues. Isoform 1 and isoform 2 have identical ligand binding properties, but isoform 2 lacks coupling to calcium mobilization and may therefore attenuate the action of PGE2 on tissues.

10116:Stat5b
gene id: 10116:Stat5b
uniprot id: A6HJ61
uniprot id: P52632
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcription factor STAT family.
messages: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
messages: Cytoplasm
messages: Nucleus
messages: Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphorylation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity.
messages: Upon activation, forms a homodimer or a heterodimer with a related family member. Binds NR3C1. Interacts with NCOA1. Interacts with NMI. Interacts with SOCS7. Interacts (via SH2 domain) with INSR. Interacts with CPEB3; this inhibits STAT5B-mediated transcriptional activation.

10116:St14
gene id: 10116:St14
uniprot id: A0A9K3Y7V3
uniprot id: Q9JJI7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
messages: Interacts with CDCP1. May interact with TMEFF1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Ly6g6d
gene id: 10116:Ly6g6d
uniprot id: Q6MG58
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer.
messages: O-glycosylated.

10116:Cckbr
gene id: 10116:Cckbr
uniprot id: P30553
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Parietal cells, pancreas, brain and various neoplastic tissues.
messages: Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

10116:Slc27a5
gene id: 10116:Slc27a5
uniprot id: A6KQM0
uniprot id: Q9ES38
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Inhibited by mono-unsaturated fatty acids, palmitoleic acid and oleic acid and nonionic detergents, triton X-100 and polyethylene glycol hexadecyl ether (Brij 58).
messages: Mediates the import of long-chain fatty acids (LCFA) by facilitating their transport across cell membranes (By similarity). Also catalyzes the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (By similarity). Mainly functions as a bile acyl-CoA synthetase catalyzing the activation of bile acids via formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed:12454267, PubMed:12951368). In particular, catalyzes the activation of the primary bile acid, chenodeoxycholic acid (PubMed:12454267, PubMed:12951368). Primary bile acid cholic acid and secondary bile acids (deoxycholic acid and lithocholic acid) are principal substrates too (By similarity). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate ((25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate or THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (By similarity). Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (By similarity).
messages: Microsome
messages: Predominantly expressed in liver (at protein level).

10116:Creg1
gene id: 10116:Creg1
uniprot id: B2GUX7
uniprot id: F7FH64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

10116:Angpt1
gene id: 10116:Angpt1
uniprot id: O35460
names: Function
names: Subcellular Location Annotation
messages: Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.
messages: Secreted

10116:Stx4
gene id: 10116:Stx4
uniprot id: A0A8I5ZKM3
uniprot id: Q08850
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the syntaxin family.
messages: Cell membrane
messages: Expressed in all tissues tested including adipose, brain, testis, intestine, liver, heart, spleen, skeletal muscle and kidney.
messages: Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4. Interacts with SNAP23 and SNAPIN. Interacts with VAMP2. Interacts with LLGL1. Interacts (via C-terminus) with CENPF. Interacts with DOC2B. Interacts with STXBP3; excludes interaction with DOC2B and SNAP25. Interacts with STXBP4; excludes interaction with VAMP2 (By similarity). Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during lysosomal exocytosis. Interacts with STXBP6. Interacts with STXBP5L (By similarity).
messages: Membrane
messages: Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity). Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity). In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (PubMed:32963038). Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity).
messages: neuron projection

10116:Mat2a
gene id: 10116:Mat2a
uniprot id: P18298
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
messages: Exhibits night/day variations with a 5-fold increased expression at night in the pineal gland (at protein level). Up-regulation is due to a large degree to the release of norepinephrine from nerve terminals in the pineal gland and cAMP signaling pathway.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain.
messages: In mammalian tissues, there are three distinct forms of AdoMet synthases designated as alpha, beta, and gamma. Alpha and beta are expressed only in adult liver, while gamma is widely distributed in extrahepatic tissues. In addition, the gamma form predominantly exists in fetal rat liver and is progressively replaced by the alpha and beta forms during development. In the brain, highly expressed at night in pinealocytes (at protein level). Low expression in the medial habenular nucleus, granular layer of the cerebellum, layer II of the neocortex and the pyramidal cells and granular cells of the hippocampal formation.

10116:Or8k25
gene id: 10116:Or8k25
uniprot id: A0A0G2K186
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Vps37c
gene id: 10116:Vps37c
uniprot id: B5DFF4
uniprot id: M0R461
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

10116:Or11g24
gene id: 10116:Or11g24
uniprot id: A0A8I6A0M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Rnf13
gene id: 10116:Rnf13
uniprot id: A6JVH0
uniprot id: Q66HG0
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated.
messages: E3 ubiquitin-protein ligase that regulates cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. Also involved in protein trafficking and localization.
messages: Endoplasmic reticulum membrane
messages: Interacts with ERN1.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Nucleus inner membrane
messages: The RING-type zinc finger domain is required for E3 ligase activity and for promoting ER stress-induced JNK activation and apoptosis.

10116:Napsa
gene id: 10116:Napsa
uniprot id: A6JAR3
uniprot id: Q68G15
names: Similarity
messages: Belongs to the peptidase A1 family.

10116:Osbpl8
gene id: 10116:Osbpl8
uniprot id: A0A0G2JXN8
uniprot id: A0A8I6GDH8
uniprot id: A6IGF8
names: Similarity
messages: Belongs to the OSBP family.

10116:Ddx39b
gene id: 10116:Ddx39b
uniprot id: Q63413
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DEAD box helicase family. DECD subfamily.
messages: Cytoplasm
messages: Highly expressed in liver.
messages: Homodimer, and heterodimer with DDX39A. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure involving ATP-dependent remodeling; in the complex bridges ALYREF/THOC4 and the THO complex, and, in a ATP-dependent manner, ALYREF/THOC4 and SARNP/CIP29. Component of the spliceosome. Interacts directly with U2AF2. Interacts with RBM8A, RNPS1 and SRRM1, FYTTD1/UIF, THOC1, MX1 and POLDIP3. Interacts with LUZP4.
messages: Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability.
messages: Nucleus
messages: Nucleus speckle
messages: Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [] reporting a stimulatory effect.
messages: The helicase C-terminal domain mediates interaction with ALYREF/THOC4.

10116:Cwf19l1
gene id: 10116:Cwf19l1
uniprot id: A6JHE9
uniprot id: D3Z863
names: Similarity
messages: Belongs to the CWF19 family.

10116:Calhm2
gene id: 10116:Calhm2
uniprot id: Q5RJQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane
messages: Pore-forming subunit of a voltage-gated ion channel.

10116:Dclk3
gene id: 10116:Dclk3
uniprot id: F1LWF2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

10116:Kcnc2
gene id: 10116:Kcnc2
uniprot id: A6IGI7
uniprot id: A6IGJ0
uniprot id: A6IGJ3
uniprot id: P22462
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily.
messages: Cell membrane
messages: Expressed in neurons of the visual cortex during postnatal development (PubMed:18708127). Expressed in neurons of the globus pallidus at postnatal age day 7 (P7), onward (PubMed:10482766). Expressed in thalamic relay neurons. Expressed in neurons in layer IV and deeper cortical layers of the neocortex. Expressed in hippocampal interneurons (PubMed:7643197). Expressed in nonpyramidal interneurons in the basolateral amygdala (PubMed:16413129). Expressed in retinal ganglion cells (at protein level) (PubMed:22831914). Widely expressed in the brain (PubMed:1879548, PubMed:8120636). Expressed in numerous thalamic relay neurons throughout the dorsal thalamus. Expressed in interneurons of the deep layers V-VI of the cerebral cortex, the CA1 and CA3 pyramidal and dentate gyrus (DG) granule cells of the hippocampus, in neurons of the caudate-putamen, globus pallidus and subthalamic nucleus. Also expressed in the optic layer of interior colliculus, the inferior colliculus, the red nucleus, the medial geniculate, the ventral lateral lemiscus, the reticulotegmental nucleus and in the deep cerebellar nuclei (PubMed:1374908, PubMed:8120636, PubMed:7643197, PubMed:18708127). Expressed in globus pallidus (GP) neurons (PubMed:10414968).
messages: Homotetramer and heterotetramer with other channel-forming alpha subunits, such as KCNC1. Interacts with KCNC1 (PubMed:10482766, PubMed:14679187). Homotetramer or heterotetramer channel activity is regulated by association with modulating ancillary subunits such as KCNE1, KCNE2 and KCNE3, creating a functionally diverse range of channel complexes. Interacts with KCNE1, KCNE2 and KCNE3 (PubMed:14679187).
messages: Inhibited by Stichodactyla helianthus peptide ShK (By similarity). Inhibited by millimolar levels of tetraethylammonium (TEA). Contrary to other channels, inhibited only by millimolar levels of 4-aminopyridine (4-AP) (PubMed:2367536, PubMed:1879548, PubMed:7643197, PubMed:10482766, PubMed:10414303).
messages: Membrane
messages: Perikaryon
messages: Phosphorylated by PKA in cortical synaptosomes (PubMed:7643197). cAMP-dependent phosphorylation inhibits channel activity (PubMed:7643197). Histamine H2 receptor- and PKA-induced phosphorylation extends action potential spike duration, reduces action potential spike amplitude, sustains maximum firing frequency in hippocampal interneurons; also reduces the incidence of high-frequency oscillations in hippocampal CA3 pyramidal cell layers (By similarity).
messages: Postsynaptic cell membrane
messages: Presynaptic cell membrane
messages: Synapse
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
messages: Up-regulated in visual cortex during the second postnatal week from dark-reared animals (at protein level). Down-regulated in visual cortex by active visual experience until postnatal day P40 of dark-reared animals (PubMed:18708127). Down-regulated by chronic action potential activity deprivation in organotypic culture of the visual cortex (PubMed:18775767).
messages: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system (PubMed:10482766, PubMed:10414968, PubMed:11506885, PubMed:22831914). Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly (PubMed:2367536, PubMed:1879548, PubMed:8120636, PubMed:7643197, PubMed:10414303). Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2367536, PubMed:1879548, PubMed:8120636, PubMed:7643197). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:10482766, PubMed:14679187). Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 and KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (PubMed:11281123, PubMed:14679187). Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons (PubMed:10482766, PubMed:10414968, PubMed:11506885, PubMed:22831914). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent m…
messages: axon
messages: dendrite
messages: synaptosome

10116:Mpped2
gene id: 10116:Mpped2
uniprot id: B1WBP0
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the UPF0046 family.
messages: Displays low metallophosphoesterase activity (in vitro) (PubMed:19004815, PubMed:21824479). May play a role in the development of the nervous system (Probable).
messages: Expressed in fetal brain (at protein level). detected in fetal and adult brain.
messages: Homodimer.
messages: Inhibited by nmolar levels of AMP and GMP.
messages: This protein has a low affinity for cofactor and demonstrates very restricted substrate specificity. The enzyme may need additional interacting proteins to show full activity, or may be losing its activity and acquiring the role of a scaffolding protein.

10116:Plau
gene id: 10116:Plau
uniprot id: A6KKR2
uniprot id: F7F966
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Dpy19l4
gene id: 10116:Dpy19l4
uniprot id: A6JFT1
uniprot id: D3Z939
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

10116:Reep6
gene id: 10116:Reep6
uniprot id: A0A8I6AGE9
uniprot id: A6K8M3
uniprot id: A6K8M4
uniprot id: Q5XI60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DP1 family.
messages: Detected in retina.
messages: Endoplasmic reticulum membrane
messages: Interacts with STX3 (By similarity). Interacts with clathrin (By similarity).
messages: Membrane
messages: Required for correct function and survival of retinal photoreceptors (By similarity). Required for retinal development (By similarity). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity).
messages: clathrin-coated vesicle membrane

10116:Entpd2
gene id: 10116:Entpd2
uniprot id: F1M7N2
uniprot id: O35795
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the GDA1/CD39 NTPase family.
messages: By FSH in Sertoli cells but not in peritubular cells; by cAMP in both type of cells.
messages: Cell membrane
messages: Expressed in brain, heart, vas deferens, kidney, skeletal muscle, thymus, lung and spleen. Weak expression in liver.
messages: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent.

10116:Cops9
gene id: 10116:Cops9
uniprot id: B5DFN0
names: Similarity
messages: Belongs to the CSN9 family.

10116:Olr880
gene id: 10116:Olr880
uniprot id: A6KSL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Rap1a
gene id: 10116:Rap1a
uniprot id: P62836
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR.
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Early endosome
messages: Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (active GTP-bound form preferentially) with KRIT1 (via C-terminus FERM domain); the interaction does not induce the opening conformation of KRIT1. In its GTP-bound form interacts with PLCE1 and RADIL. Interacts with SGSM1, SGSM2 and SGSM3. Interacts (via GTP-bound active form) with RAPGEF2 (via Ras-associating domain) (By similarity). Interacts with TBC1D21 (By similarity). Interacts with RAP1GDS1 (By similarity).
messages: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.
messages: Late endosome
messages: perinuclear region

10116:Scamp5
gene id: 10116:Scamp5
uniprot id: A0A0G2K464
uniprot id: A6J4V3
uniprot id: Q9JKE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAMP family.
messages: Belongs to the SCAMP family. SCAMP5 subfamily.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Interacts (via C-terminal part) with SYT1 and SYT2; interaction with synaptotagmins making a link with the SNARE molecules. Interacts with SLC9A7 (By similarity).
messages: Membrane
messages: Recycling endosome membrane
messages: Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery (By similarity).
messages: synaptic vesicle membrane
messages: trans-Golgi network membrane

10116:Nxt1
gene id: 10116:Nxt1
uniprot id: B2RZ65
uniprot id: F7EK82
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

10116:Dpy19l2
gene id: 10116:Dpy19l2
uniprot id: A0A8I6G8Q8
uniprot id: M0RC58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

10116:Ccdc146
gene id: 10116:Ccdc146
uniprot id: Q66H60
names: Subcellular Location Annotation
messages: centrosome

10116:Gamt
gene id: 10116:Gamt
uniprot id: A6K8N3
uniprot id: G3V960
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
messages: Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor.
messages: Monomer.

10116:Rbbp5
gene id: 10116:Rbbp5
uniprot id: A6IC52
uniprot id: D3ZC01
names: Subcellular Location Annotation
messages: Nucleus

10116:LOC292543
gene id: 10116:LOC292543
uniprot id: Q4V799
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

10116:Pyroxd1
gene id: 10116:Pyroxd1
uniprot id: Q68FS6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Nucleus
messages: Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response (By similarity). Required for normal sarcomere structure and muscle fiber integrity (By similarity).
messages: sarcomere

10116:Oca2
gene id: 10116:Oca2
uniprot id: Q4LEV3
names: Subcellular Location Annotation
messages: Membrane

10116:Itga3
gene id: 10116:Itga3
uniprot id: I4DUB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

10116:H1f6
gene id: 10116:H1f6
uniprot id: A6KLN1
uniprot id: P06349
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Citrullination at Arg-56 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
messages: Nucleus
messages: Phosphorylated in early spermatids.
messages: Testis-specific (PubMed:2423516, PubMed:1706721). Expressed in pachytene spermatocytes during meiotic prophase I (PubMed:1706721).
messages: Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration.
messages: The Gln-54 residue in the globular domain forms a hydrogen bond with the main chain carbonyl of Met-52 and is spatially oriented away from the nucleosome dyad axis, leading to lower affinity towards Four-way junction DNA and reconstituted 5S mononucleosomes.
messages: This histone is a testis-specific H1 variant that appears during meiosis in spermatogenesis.

10116:Churc1
gene id: 10116:Churc1
uniprot id: B5DER2
uniprot id: F7FBS9
names: Similarity
messages: Belongs to the Churchill family.

10116:Mapk9
gene id: 10116:Mapk9
uniprot id: A0A8I6AND2
uniprot id: A6HDY2
uniprot id: A6HDY4
uniprot id: P49186
uniprot id: Q6P727
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183 preferentially. Inhibited by dual specificity phosphatases, such as DUSP1.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Autophosphorylated in vitro.
messages: Interacts with MECOM (PubMed:10856240). Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway (By similarity). Interacts with NFATC4 (By similarity). Interacts with ATF7; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN (By similarity). Interacts with BCL10 (By similarity). Interacts with CTNNB1 and GSK3B (By similarity). Interacts with DCLK2 (By similarity). Interacts with MAPKBP1 (By similarity). Interacts with POU5F1; phosphorylates POU5F1 at 'Ser-347'. Found in a complex with SH3RF1, RAC2, MAP3K7/TAK1, MAP2K7/MKK7, MAPK8IP1/JIP1 and MAPK8/JNK1 (By similarity).
messages: Nucleus
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.
messages: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock. Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation.
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

10116:Ppp2r3c
gene id: 10116:Ppp2r3c
uniprot id: A0A8L2QGM6
uniprot id: Q6AXZ3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with MCM3AP/GANP, PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.
messages: May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.
messages: Nucleus

10116:Tbx18
gene id: 10116:Tbx18
uniprot id: A6I1X6
uniprot id: D4A1V6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

10116:Nelfcd
gene id: 10116:Nelfcd
uniprot id: A0A8I6B5Y3
uniprot id: A6KL31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NELF-D family.
messages: Nucleus

10116:Shtn1
gene id: 10116:Shtn1
uniprot id: A0MZ67
uniprot id: A6JI78
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the shootin family.
messages: Brain-specific (at protein level) (PubMed:17030985). Expressed in hippocampal neurons (PubMed:18519736).
messages: Expressed in hippocampal neurons at 18 dpc (PubMed:23408951). Expressed at high level both in hippocampal neurons and in brain, during the period of axon formation and elongation. Accumulates in axonal growth cones during the stage 2/3 transition. Accumulates asymmetrically in a single neurite before polarization, while it is depleted in its sibling neurites, through competitive transport to multiple neurites. Transported anterogradely to the growth cones and diffused back to the soma (at protein level) (PubMed:17030985).
messages: Interacts with PFN2. Interacts (via N-terminus) with KIF20B; this interaction is direct and promotes the association of SHTN1 to microtubules in primary neurons. Associates with microtubule (By similarity). Interacts with L1CAM; this interaction occurs in axonal growth cones (PubMed:18519736). Interacts with actin filament retrograde flow; this interaction is enhanced in a netrin-1- and PAK1-dependent manner and promotes F-actin-substrate coupling and concomitant formation of traction forces at axonal growth cones (PubMed:18519736, PubMed:23453953). Interacts with RUFY3 (PubMed:17030985).
messages: Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth (PubMed:17030985, PubMed:17439943, PubMed:18519736, PubMed:20664640). Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth (PubMed:18519736, PubMed:23453953). Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone (PubMed:17030985). Also plays a role in regenerative neurite outgrowth (PubMed:20664640). In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons (By similarity).
messages: Perikaryon
messages: Phosphorylated on Ser-101 and Ser-249 by PAK1 through a CDC42- and RAC1-dependent signaling pathway, which enhances its association with F-actin retrograde flow in filopodia and lamellipodia of axonal growth cones (PubMed:23453953). Phosphorylation on Ser-101 and Ser-249 is increased by netrin-1 (PubMed:23453953).
messages: The N-terminus region is necessary for interaction with actin retrograde filament flow and accumulation in neuronal growth cones (PubMed:18519736).
messages: Up-regulated by axonal regeneration (PubMed:20664640).
messages: axon
messages: cytoskeleton
messages: filopodium
messages: growth cone
messages: lamellipodium

10116:Pptc7
gene id: 10116:Pptc7
uniprot id: A6J1A7
uniprot id: D4A520
names: Similarity
messages: Belongs to the PP2C family.

10116:Lhx8
gene id: 10116:Lhx8
uniprot id: A0A8J8Y3T8
names: Subcellular Location Annotation
messages: Nucleus

10116:Bet1l
gene id: 10116:Bet1l
uniprot id: A6HXK9
uniprot id: O35152
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of a SNARE complex consisting of STX5, YKT6, GOSR2 and BET1L.
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex.
messages: Widely expressed. Highest levels in heart, liver, skeletal muscle and kidney.
messages: trans-Golgi network membrane

10116:Adgrl4
gene id: 10116:Adgrl4
uniprot id: A6HWI6
uniprot id: Q9ESC1
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundantly expressed in heart, lung, and kidney. Less evident expression is observed in brain, skeletal muscle, liver and spleen. No expression is detected in testis.
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Endothelial orphan receptor that acts as a key regulator of angiogenesis.
messages: Glycosylated.
messages: Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
messages: The transmembrane domain is not required for cleavage, but it is required for dimer formation.
messages: Up-regulated in the adult heart.

10116:Mrps15
gene id: 10116:Mrps15
uniprot id: A6IS84
uniprot id: Q5XI37
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins (By similarity). Interacts with METTL17 (By similarity).
messages: Mitochondrion matrix

10116:Lcmt1
gene id: 10116:Lcmt1
uniprot id: Q6P4Z6
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

10116:Or9g4
gene id: 10116:Or9g4
uniprot id: A0A0G2K620
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Nop10
gene id: 10116:Nop10
uniprot id: A6HP45
uniprot id: D3ZMP6
names: Similarity
messages: Belongs to the NOP10 family.

10116:Cwc25
gene id: 10116:Cwc25
uniprot id: A6HIM6
uniprot id: G3V6I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

10116:Or2y1h
gene id: 10116:Or2y1h
uniprot id: A0A8I5ZV46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Mgst1
gene id: 10116:Mgst1
uniprot id: B6DYQ4
uniprot id: P08011
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MAPEG family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Endoplasmic reticulum membrane
messages: Highest in the liver, followed by kidney and testis and much lower in seminal vesicles, spleen, lung and brain.
messages: Homotrimer; The trimer binds only one molecule of glutathione.
messages: In vitro, can be activated by reagents that attack Cys-50 sulfhydryl, such as N-ethylmaleimide and via nitration of Tyr-93 by peroxynitrite.
messages: In vitro, peroxynitrite induces nitration at Tyr-93 which activates the enzyme.
messages: Membrane
messages: Mitochondrion outer membrane

10116:Poc5
gene id: 10116:Poc5
uniprot id: Q4V891
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the POC5 family.
messages: Essential for the assembly of the distal half of centrioles, required for centriole elongation.
messages: Hyperphosphorylated during recruitment to procentrioles in G2/M phase.
messages: Interacts with CETN2 and CETN3.
messages: centriole

10116:Pex16
gene id: 10116:Pex16
uniprot id: Q5FVJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-16 family.
messages: Peroxisome membrane

10116:Prl7a3
gene id: 10116:Prl7a3
uniprot id: Q9R006
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the somatotropin/prolactin family.
messages: Expression restricted to placental tissues. Trophoblast giant cells are found to be the major source.
messages: Secreted

10116:Rflna
gene id: 10116:Rflna
uniprot id: A6J0X5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

10116:Il20
gene id: 10116:Il20
uniprot id: A6IC09
uniprot id: D4A2T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

10116:Tmprss15
gene id: 10116:Tmprss15
uniprot id: A6JL47
names: Caution
names: Similarity
messages: Belongs to the DMBT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Hdac3
gene id: 10116:Hdac3
uniprot id: Q6P6W3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Cytoplasm
messages: Deubiquitinated on 'Lys-63'-linked ubiquitin chains by USP38; leading to a decreased level of histone acetylation.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression (By similarity). Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (By similarity). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (By similarity). Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner. During the activation phase, promotes the accumulation of ubiquitinated BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and BMAL1. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). Also functions as deacetylase for non-histone targets, such as KAT5, MEF2D, MAPK14 and RARA. Serves as a corepressor of RARA, mediating its deacetylation and repression, leading to inhibition of RARE DNA element binding. In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response. In addition to protein deacetylase activity, also acts as protein-lysine deacylase by recognizing other acyl groups: …
messages: Interacts with BTBD14B (PubMed:16033423). Interacts with HDAC7 and HDAC9. Interacts with HDAC10, DAXX and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY. Interacts with GLIS2. Interacts (via the DNA-binding domain) with NR2C1; the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation. Component of the Notch corepressor complex. Interacts with CBFA2T3 and NKAP. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Interacts with and deacetylates MAPK14. Interacts with ZMYND15. Interacts with SMRT/NCOR2 and BCL6 on DNA enhancer elements. Interacts with INSM1. Interacts with XBP1; the interaction occurs in endothelial cell (EC) under disturbed flow. Interacts (via C-terminus) with CCAR2 (via N-terminus). Interacts with and deacetylates MEF2D (By similarity). Interacts with BEND3 (By similarity). Interacts with NKAPL (By similarity). Interacts with DHX36; this interaction occurs in a RNA-dependent manner (By similarity). Interacts weakly with CRY1; this interaction is enhanced in the presence of FBXL3 (By similarity). Interacts with FBXL3 and BMAL1 (By similarity). Interacts with NCOR1 (By similarity). Interacts with RARA (By similarity). Interacts with SETD5 (By similarity).
messages: Nucleus
messages: Sumoylated in vitro.
messages: cytosol

10116:Evl
gene id: 10116:Evl
uniprot id: O08719
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization (By similarity).
messages: Homotetramer (By similarity). Binds to the SH3 domains of ABL1, LYN and SRC. Also binds to profilin, with preference for isoform IIa of PFN2, and the WW domain of APBB1/FE65. Binds to SEMA6A. Interacts, via the Pro-rich region, with the C-terminal SH3 domain of DNMBP. Interacts with RAPH1. Binds, via the EVH1 domain, the Pro-rich domain of Listeria monocytogenes actA (By similarity). Binds, via the EVH1 domain, the Pro-rich domain of ZYX. Interacts with FYB1. Interacts with ZDHHC17 (By similarity).
messages: Phosphorylated by PKA; phosphorylation abolishes binding to SH3 domains of ABL and SRC.
messages: The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization.
messages: cytoskeleton
messages: lamellipodium
messages: stress fiber

10116:Hmgb2
gene id: 10116:Hmgb2
uniprot id: A6KIU7
uniprot id: P52925
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HMGB family.
messages: Both, HMG box 1 and HMG box 2, show antimicrobial activity.
messages: Chromosome
messages: Cytoplasm
messages: Interacts with POU2F2, POU2F1 and POU3F1. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Directly interacts with SET. Interacts with LEF1.
messages: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes (By similarity). Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE. Has antimicrobial activity in gastrointestinal epithelial tissues. Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity. May play a role in germ cell differentiation. Involved in modulation of neurogenesis probably by regulation of neural stem proliferation. Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).
messages: Nucleus
messages: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB2 (HMGB2C23hC45hC106h), 2- disulfide HMGB2 (HMGB2C23-C45C106h) and 3- sulfonyl HMGB2 (HMGB2C23soC45soC106so).
messages: Secreted

10116:Ppp3ca
gene id: 10116:Ppp3ca
uniprot id: P63329
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by Ca(2+)-bound calmodulin following an increase in intracellular Ca(2+) (PubMed:1322410, PubMed:24018048). At low Ca(2+) concentrations, the catalytic subunit (also known as calcineurin A) is inactive and is bound to the regulatory subunit (also known as calcineurin B) in which only two high-affinity binding sites are occupied by Ca(2+) (PubMed:1322410, PubMed:24018048). In response to elevated calcium levels, the occupancy of the low-affinity sites on calcineurin B by Ca(2+) causes a conformational change of the C-terminal regulatory domain of calcineurin A, resulting in the exposure of the calmodulin-binding domain and in the partial activation of calcineurin A (PubMed:1322410, PubMed:24018048). The subsequent binding of Ca(2+)-bound calmodulin leads to the displacement of the autoinhibitory domain from the active site and possibly of the autoinhibitory segment from the substrate binding site which fully activates calcineurin A (PubMed:1322410, PubMed:24018048). Inhibited by immunosuppressant drug FK506 (tacrolimus) in complex with FKBP12 and also by immunosuppressant drug cyclosporin A (CsA) in complex with PPIA/cyclophilin A; the inhibition is Ca(2+)-dependent (By similarity).
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:1322410, PubMed:24018048). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (By similarity). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (By similarity). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (By similarity). Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (PubMed:23699505). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (By similarity). Dephosphorylates and inactivates transcription factor ELK1 (By similarity). Dephosphorylates DARPP32 (By similarity). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (By similarity). Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (By similarity). Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (By similarity). Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (By similarity). Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (By similarity). Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (By similarity). Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (By similarity)…
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in neonatal cardiomyocytes (at protein level) (PubMed:11114196). Expressed in hippocampal presynaptic termini (at protein level) (PubMed:23699505).
messages: Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit (also known as calcineurin B) (By similarity). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2). In response to an increase in Ca(2+) intracellular levels, forms a complex composed of PPP3CA/calcineurin A, calcineurin B and calmodulin (By similarity). Interacts (via calcineurin B binding domain) with regulatory subunit PPP3R1/calcineurin B (By similarity). Interacts (via calmodulin-binding domain) with calmodulin; the interaction depends on calmodulin binding to Ca(2+) (By similarity). Forms a complex composed of MYOZ2 and ACTN1 (By similarity). Within the complex interacts with MYOZ2 (By similarity). Interacts with MYOZ1 (By similarity). Interacts with MYOZ3 (By similarity). Interacts with CIB1; the interaction increases upon cardiomyocyte hypertrophy (By similarity). Interacts with CHP1 and CHP2 (PubMed:10593895, PubMed:18815128). Interacts with CRTC1. Interacts with CRTC2 (By similarity). Interacts with DNM1L; the interaction dephosphorylates DNM1L and promotes its translocation to mitochondria (By similarity). Interacts with CMYA5; this interaction represses calcineurin activity in muscle (By similarity). Interacts (constitutively active form) with SYNPO2 (By similarity). Interacts with scaffold protein AKAP5 (via IAIIIT motif); the interaction recruits PPP3CA to the plasma membrane following L-type Ca(2+)-channel activation (By similarity). Interacts with NFATC2 (By similarity). Interacts with RCAN3 (By similarity). Interacts with PPIA. Interacts with RCAN1 (By similarity). Interacts with UNC119 (By similarity). Interacts with C16orf74 (via PxIxIT motif, when phosphorylated on 'Thr-76') (By similarity). Interacts (via N-terminus) with MAP3K14/NIK (via C-terminus and kinase domain) (By simil…
messages: Possible isomerization of Pro-309 within the SAPNY motif triggers a conformation switch which affects the organization and thus accessibility of the active site and the substrate binding region (PxIxIF motif). The trans- to cis-transition may favor calcineurin A activation and substrate binding. The reverse cis- to trans-transition may be enhanced by peptidyl-prolyl isomerases such as PPIA.
messages: The autoinhibitory domain prevents access to the catalytic site.
messages: The autoinhibitory segment prevents access to the substrate binding site.
messages: Z line
messages: dendritic spine
messages: sarcolemma

10116:Terf1
gene id: 10116:Terf1
uniprot id: A0A8I5Y1U3
uniprot id: A6JFC1
uniprot id: F7EVI5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
messages: Homodimer.
messages: Nucleus
messages: telomere

10116:Gch1
gene id: 10116:Gch1
uniprot id: A6KE40
uniprot id: P22288
names: Activity Regulation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: By cytokines such as insulin, interferon-gamma, and phytohemagglutinin in adrenal gland, macrophages, and T-cell respectively.
messages: Cytoplasm
messages: GTP shows a positive allosteric effect, and tetrahydrobiopterin inhibits the enzyme activity. Zinc is required for catalytic activity. Inhibited by Mg(2+).
messages: May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence.
messages: Nucleus
messages: Phosphorylated.
messages: Toroid-shaped homodecamer, composed of two pentamers of five dimers. Interacts with AHSA1 and GCHFR/GFRP.

10116:Ephx2
gene id: 10116:Ephx2
uniprot id: P80299
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.
messages: Bifunctional enzyme (PubMed:8626766, PubMed:12574508). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:8626766). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (By similarity).
messages: Bifunctional enzyme (PubMed:8626766, PubMed:12574508). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:8626766). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (PubMed:8626766). Also determines steady-state levels of physiological mediators (By similarity). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (By similarity).
messages: Bifunctional enzyme (PubMed:8626766, PubMed:12574508). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (PubMed:12574508). Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates (By similarity).
messages: By compounds that cause peroxisome proliferation such as clofibrate, tiadenol and fenofibrate.
messages: Cytoplasm
messages: Homodimer.
messages: Inhibited by 1-(1-acetylpiperidin-4-yl)-3-(4-(trifl uoromethoxy)phenyl)urea (TPAU), 1-cyclohexyl-3-dodecylurea (CDU), 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA), 1-((3S, 5S, 7S)-adamantan-1-yl)-3-(5-(2-(2-ethoxyethoxy) ethoxy)pentyl)urea (AEPU), N-adamantyl-N[']-cyclohexyl urea (ACU), 4-(((1S, 4S)-4-(3-((3S, 5S, 7S)-adamantan-1-yl) ureido)cyclohexyl)oxy)benzoic acid (c-AUCB), 4-(((1R, 4R)-4-(3-((3S, 5S, 7S)-adamantan-1-yl)ureido)cyclohexyl)oxy)benzoic acid (t-AUCB), 4-(((1R, 4R)-4-(3-(4(trifluoromethoxy)phenyl)ureido)cyclohexyl)oxy)benzoic acid (t-TAUCB) and to a lesser extent by 8-(3-((3S, 5S, 7S)-adamantan-1-yl)ureido) octanoic acid (AUOA) (PubMed:21217101). Phosphatase activity is inhibited by dodecyl-phosphate, phospholipids such as phospho-lysophosphatidic acids and fatty acids such as palmitic acid and lauric acid (By similarity).
messages: Peroxisome
messages: The N-terminal domain has phosphatase activity. The C-terminal domain has epoxide hydrolase activity.
messages: The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation (By similarity).

10116:Olr1069
gene id: 10116:Olr1069
uniprot id: D4AA37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Them4
gene id: 10116:Them4
uniprot id: Q566R0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THEM4/THEM5 thioesterase family.
messages: Cell membrane
messages: Cytoplasm
messages: Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism (By similarity). Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity (By similarity).
messages: Homodimer and homotetramer (By similarity). Interacts with AKT1 in the cytosol (By similarity).
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: Phosphorylated.
messages: ruffle membrane

10116:Sh3rf3
gene id: 10116:Sh3rf3
uniprot id: M0R6D9
names: Similarity
messages: Belongs to the SH3RF family.

10116:Nr2f1
gene id: 10116:Nr2f1
uniprot id: Q62681
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

10116:Trim2
gene id: 10116:Trim2
uniprot id: D3ZM62
uniprot id: D3ZQG6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Forms homooligomers (By similarity). Interacts with TRIM3; this interaction reduces TRIM2 activity (By similarity). Interacts with myosin V; myosin V may not be a substrate for ubiquitination. Interacts with NEFL. Interacts with phosphorylated BCL2L11. Interacts with SIRPA (By similarity).
messages: RING-type zinc finger-dependent and UBE2D1-dependent autoubiquitination.
messages: The interaction with myosin V is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.
messages: UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity.

10116:Cox4i1
gene id: 10116:Cox4i1
uniprot id: A6IZM8
uniprot id: P10888
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with PHB2; the interaction decreases in absence of SPHK2 (By similarity). Interacts with AFG1L (By similarity). Interacts with ABCB7; this interaction allows the regulation of cellular iron homeostasis and cellular reactive oxygen species (ROS) levels in cardiomyocytes (PubMed:31511561). Interacts with FLVCR2; this interaction occurs in the absence of heme and is disrupted upon heme binding.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

10116:Psap
gene id: 10116:Psap
uniprot id: A0A8I6ASQ4
uniprot id: A6K3W9
uniprot id: A6K3X0
uniprot id: P10960
uniprot id: Q6P7A4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
messages: Lysosome
messages: Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
messages: Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.
messages: Saposin-B is a homodimer. Prosaposin exists as a roughly half-half mixture of monomers and disulfide-linked dimers. Monomeric prosaposin interacts (via C-terminus) with sortilin/SORT1, the interaction is required for targeting to lysosomes. Interacts with GRN; facilitates lysosomal delivery of progranulin from the extracellular space and the biosynthetic pathway (By similarity).
messages: Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.
messages: Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).
messages: Saposins are specific low-molecular mass non-enzymatic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
messages: Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
messages: Secreted

10116:Pycr1
gene id: 10116:Pycr1
uniprot id: A0A8I6AII4
uniprot id: A6HLH3
uniprot id: D3ZXI0
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

10116:Ptp4a3
gene id: 10116:Ptp4a3
uniprot id: A0A8I5Y855
uniprot id: B0K032
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

10116:Olr193
gene id: 10116:Olr193
uniprot id: D4A7I0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Kcnh6
gene id: 10116:Kcnh6
uniprot id: A0A1B0GWV8
uniprot id: O54853
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.2/KCNH6 sub-subfamily.
messages: Highly expressed in celiac and superior mesenteric ganglia, but not detected in brain or in heart. Detected at low levels in retina. Also found in pituitary. Also found in the olfactory bulb (granular and mitral cell layers) (PubMed:11425889).
messages: Membrane
messages: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current. Channel properties may be modulated by cAMP and subunit assembly.
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH7/ERG3.
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

10116:Lsm1
gene id: 10116:Lsm1
uniprot id: A6IW03
uniprot id: D3ZWB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

10116:Slc26a3
gene id: 10116:Slc26a3
uniprot id: A6HB46
uniprot id: Q924C9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Interacts with PDZK1, CFTR, SLC26A6 and NHERF1 (By similarity). Interacts (via PDZ-binding motif) with NHERF4 (via the third PDZ domain); interaction leads to decreased expression of SLC26A3 on the cell membrane resulting in its reduced exchanger activity (By similarity).
messages: Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).
messages: Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Membrane
messages: N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation.

10116:Nova1
gene id: 10116:Nova1
uniprot id: A0A0G2JVE8
uniprot id: A0A8I6G9C1
uniprot id: A6HBF6
uniprot id: D4AAF8
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PTBP2; the interaction is direct.
messages: Nucleus

10116:Or4k15c
gene id: 10116:Or4k15c
uniprot id: D3ZSE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Defb17
gene id: 10116:Defb17
uniprot id: Q32ZH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

10116:Taf5l1
gene id: 10116:Taf5l1
uniprot id: B1H284
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

10116:Plscr5
gene id: 10116:Plscr5
uniprot id: M0RA77
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

10116:Ppif
gene id: 10116:Ppif
uniprot id: A6KMH2
uniprot id: P29117
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated at Lys-166; deacetylated at Lys-166 by SIRT3.
messages: Associates with the mitochondrial membrane ATP synthase F(1)F(0) ATP synthase; the association is increased by inorganic phosphate (Pi) and decreased by cyclosporin A (CsA) (By similarity). Interacts with ATP5F1B; ATP5PD and ATP5PO (By similarity). Interacts with SLC25A3; the interaction is impaired by CsA (PubMed:18667415). Interacts with BCL2; the interaction is impaired by CsA (PubMed:19228691). Interacts with TP53; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by CsA (By similarity). Interacts with C1QBP (By similarity). Interacts with MCUR1 (By similarity). Component of the mitochondrial permeability transition pore complex (mPTPC), at least composed of SPG7, VDAC1 and PPIF (PubMed:9874241). Interacts with SPG7 (By similarity).
messages: Belongs to the cyclophilin-type PPIase family.
messages: Binds cyclosporin A (CsA). Is displaced by CsA from the mPTP leading to a lower open probability of the mPTP.
messages: Mitochondrion matrix
messages: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (By similarity). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:8567677, PubMed:9309684, PubMed:9820802). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:8567677, PubMed:9309684, PubMed:9820802). In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:8567677, PubMed:9309684, PubMed:9820802). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (PubMed:8567677, PubMed:9309684, PubMed:9820802). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed:19228691).
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
messages: The polyclonal antibody used in PubMed:9820802 and PubMed:9874241 and initially thought to detect SLC25A4/ANT1 in interactions with Ppif/CyP-D is rather detecting SLC25A3.

10116:Aebp1
gene id: 10116:Aebp1
uniprot id: A0A0H2UHL3
uniprot id: A2RUV9
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Although related to peptidase M14 family, lacks the active site residues and zinc-binding sites, suggesting that it has no carboxypeptidase activity.
messages: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix (By similarity). May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.
messages: Belongs to the peptidase M14 family.
messages: Expressed in aorta.
messages: Highly expressed in quiescent cells.
messages: Interacts with different types of collagen, including collagens I, III, and V (By similarity). Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN. May interact with calmodulin. Interaction with MAPK1 may stimulate DNA-binding. Binds to DNA in vitro.
messages: Phosphorylated by MAPK1 in vitro.
messages: Secreted
messages: The F5/8 type C domain binds to different types of collagen, including collagens I, III, and V.

10116:Srsf5
gene id: 10116:Srsf5
uniprot id: Q09167
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the splicing factor SR family.
messages: By insulin and hepatectomy.
messages: Extensively phosphorylated on serine residues in the RS domain.
messages: Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Interacts (via RS domain) with PHF5A (via N-terminus) (By similarity).
messages: Highly expressed in spleen and thymus.
messages: May be required for progression through G1 and entry into S phase of cell growth. May play a regulatory role in pre-mRNA splicing. Autoregulates its own expression. Plays a role in constitutive splicing and can modulate the selection of alternative splice sites (By similarity). Could play an important role in development and differentiation in the spleen and thymus.
messages: Nucleus

10116:Nckap1
gene id: 10116:Nckap1
uniprot id: P55161
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the HEM-1/HEM-2 family.
messages: Cell membrane
messages: Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Associates preferentially with the first SH3 domain of NCK. Interacts with NYAP1, NYAP2 and MYO16 (By similarity).
messages: Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
messages: Preferentially expressed in brain, heart, liver and testis.
messages: lamellipodium membrane

10116:Agrp
gene id: 10116:Agrp
uniprot id: A6IYQ5
uniprot id: F1MAG1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

10116:Bace2
gene id: 10116:Bace2
uniprot id: A6IQF8
uniprot id: Q6IE75
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Endosome
messages: Glycosylated.
messages: Golgi apparatus
messages: Melanosome
messages: Membrane
messages: Monomer. Interacts with RTN3 and RTN4.
messages: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells.
messages: Undergoes autoproteolytic cleavage.

10116:Slc5a11
gene id: 10116:Slc5a11
uniprot id: A6I8Z2
uniprot id: A6I8Z3
uniprot id: Q9Z1F2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Expressed in kidney and small intestine.
messages: Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine (PubMed:17932225). Can also transport D-chiro-inositol (DCI) but not L-fucose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (By similarity).
messages: MI transport activity inhibited by D-chiro-inositol (DCI), phlorizin (Pz) and sodium (Na(+)) (PubMed:17932225). Insulin increases D-chiro-inositol uptake (By similarity).
messages: Membrane

10116:Gnb5
gene id: 10116:Gnb5
uniprot id: A6I1C4
uniprot id: P62882
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat G protein beta family.
messages: Component of a complex composed of RGS9 (isoform RGS9-1), GNB5 and RGS9BP; within this complex, the presence of GNB5 stabilizes both itself and RGS9 and increases RGS9 GTPase-activating protein (GAP) activity. Interacts with RGS7, forming the RGS7-GNB5 complex; within this complex, the presence of GNB5 increases RGS7 GTPase-activating protein (GAP) activity. Interacts with GPR158; promotes the GTPase activator activity of the RGS7-GNB5 complex in absence of glycine, in contrast GTPase activator activity of the RGS7-GNB5 complex is inhibited in presence of glycine. Interacts with RGS6.
messages: Detected in brain.
messages: Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (By similarity). Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition (By similarity). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity).
messages: Membrane

10116:Slc6a12
gene id: 10116:Slc6a12
uniprot id: A6ILC6
uniprot id: P48056
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
messages: Cell membrane
messages: Interacts with LIN7C.
messages: Lateral cell membrane
messages: Membrane
messages: Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation (By similarity). Probably also involved in renal and hepatic osmotic regulation (By similarity).

10116:Rab31
gene id: 10116:Rab31
uniprot id: Q6GQP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Detected in brain astrocytes, spleen and intestine (at protein level).
messages: Early endosome
messages: Interacts (in GDP-bound form) with RIN3 and GAPVD1, which function as guanine exchange factors (GEF). Interacts (in GTP-bound form) with EEA1. Interacts with NGFR. Interacts with EGFR (By similarity). Interacts with OCRL. Interacts (in GTP-bound form) with APPL2; interaction contributes to or enhances recruitment of APPL2 to the phagosomes; interaction enhances Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity).
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes.
messages: phagosome
messages: phagosome membrane
messages: trans-Golgi network
messages: trans-Golgi network membrane

10116:Rdh5
gene id: 10116:Rdh5
uniprot id: A0A0G2K1R4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

10116:Slc6a19
gene id: 10116:Slc6a19
uniprot id: Q2A865
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily.
messages: By high salt intake in SHR rats. Reduced level upon high salt intake in Wistar Kyoto rats.
messages: Interacts in a tissue-specific manner with ACE2 in small intestine and with CLTRN in the kidney. Interacts with CLTRN; this interaction is required for trafficking of SLC6A19 to the plasma membrane and for its catalytic activation in kidneys. Interacts with ACE2; this interaction is required for trafficking of SLC6A19 to the plasma membrane and for its catalytic activation in intestine. Interacts with ANPEP; the interaction positively regulates its amino acid transporter activity (By similarity).
messages: Membrane
messages: Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride-independent. Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity.

10116:Aqp4
gene id: 10116:Aqp4
uniprot id: A0A0H2UHZ1
uniprot id: A6KLU9
uniprot id: P47863
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Basolateral cell membrane
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Cell projection
messages: Detected in cerebellum (PubMed:18179769, PubMed:29055082). Detected on pericapillary astrocyte endfeet in cerebellum, and in skeletal muscle (PubMed:29055082). Detected in glial lamellae in the hypothalamus (at protein level) (PubMed:16325200). Abundant in mature brain cortex, cerebellum and spinal cord. Highly expressed in the ependymal cell lining the aqueductal system and over the space of the brain in contact with the subarachnoid space. Detected in paraventricular and supraoptic nuclei, the granule cell layer of the dentate gyrus and the Purkinje cell layer in the cerebellum. Only weakly detectable in eye, kidney, intestine, and lung (PubMed:7528931).
messages: Detected in mature brain, but not in fetal brain.
messages: Endosome membrane
messages: Forms a water-specific channel (PubMed:7528931, PubMed:7509789, PubMed:19800950). Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity).
messages: Homotetramer (PubMed:16325200, PubMed:19406128). The tetramers can form oligomeric arrays in membranes (PubMed:18179769, PubMed:29055082). The size of the oligomers differs between tissues and is smaller in skeletal muscle than in brain (PubMed:29055082). Interaction between AQP4 oligomeric arrays in close-by cells can contribute to cell-cell adhesion (PubMed:16325200). Part of a complex containing MLC1, TRPV4, HEPACAM and ATP1B1 (By similarity).
messages: Isoform Long: Palmitoylated on its N-terminal region. Isoform 3: Not palmitoylated.
messages: Membrane
messages: Phosphorylation by PKC at Ser-180 promotes internalization from the cell membrane, reducing the conductance by 50% (PubMed:19800950). Phosphorylation by PKG at Ser-111 in response to glutamate increases conductance by 40% (By similarity).
messages: sarcolemma

10116:Zdhhc9
gene id: 10116:Zdhhc9
uniprot id: A1L1I1
uniprot id: Q2TGJ9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

10116:Sc5d
gene id: 10116:Sc5d
uniprot id: Q9EQS5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family.
messages: Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol in cholesterol biosynthesis.
messages: Endoplasmic reticulum membrane
messages: The histidine box domains may contain the active site and/or be involved in metal ion binding.

10116:Cnr2
gene id: 10116:Cnr2
uniprot id: A6IT74
uniprot id: C6G964
uniprot id: C6G965
uniprot id: Q9QZN9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.
messages: Expressed in spleen and brain by neurons and glial cells (at protein level). Expressed in lung, testis and thymus but not in heart, liver or kidney. Expressed in cerebellum, cortex and brainstem.
messages: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis (By similarity).
messages: Membrane
messages: Perikaryon
messages: dendrite

10116:Scn4b
gene id: 10116:Scn4b
uniprot id: Q7M730
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family.
messages: Cell membrane
messages: Contains an interchain disulfide bond with SCN2A.
messages: Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart.
messages: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.
messages: N-glycosylated.
messages: The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit (SCN2A) regulated by one or more beta subunits (SCN1B, SCN2B, SCN3B and SCN4B). SCN1B and SCN3B are non-covalently associated with SCN2A. SCN2B and SCN4B are disulfide-linked to SCN2A (PubMed:12930796, PubMed:26894959).

10116:Ruvbl1
gene id: 10116:Ruvbl1
uniprot id: A6IB44
uniprot id: P60123
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundantly expressed in testes and moderately in spleen, thymus, and lung. In mouse seminiferous tubules, is specifically localized in germ cells from late pachytene spermatocytes to round spermatids.
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Forms homohexameric rings. Can form a dodecamer with RUVBL2 made of two stacked hexameric rings; however, even though RUVBL1 and RUVBL2 are present in equimolar ratio, the oligomeric status of each hexamer is not known. Oligomerization may regulate binding to nucleic acids and conversely, binding to nucleic acids may affect the dodecameric assembly. Interaction of the complex with DHX34 results in conformational changes of the N-terminus of the RUVBL2 subunits, resulting in loss of nucleotide binding ability and ATP hydrolysis of the complex (By similarity). Interacts with the transcriptional activation domain of MYC. Component of the RNA polymerase II holoenzyme complex. May also act to bridge the LEF1/TCF1-CTNNB1 complex and TBP. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. RUVBL1 interacts with EP400. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Component of the BAF53 complex, at least composed of ACTL6A/BAF53A, RUVBL1/TIP49, SMARCA2/BRM, and TRRAP/PAF400. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Associates with alpha and gamma tubulins, particularly during metaphase and early anaphase. Interacts with NPAT. Component of the chromatin-remodeling INO80 complex; specifically part of a complex module associated with the helicase A…
messages: Membrane
messages: Nucleus
messages: Nucleus membrane
messages: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (By similarity). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (By similarity). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (By similarity). Essential for cell proliferation (By similarity). May be able to bind plasminogen at cell surface and enhance plasminogen activation (By similarity).
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.
messages: centrosome
messages: nucleoplasm

10116:Cacnb3
gene id: 10116:Cacnb3
uniprot id: A0A8I6A832
uniprot id: A6KC95
uniprot id: P54287
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calcium channel beta subunit family.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1C) and the ancillary subunits CACNB3 and CACNA2D1 (Probable). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio (Probable). Interacts with CACNA2D4. Interacts with FASLG (By similarity). Interacts with CBARP; prevents the interaction of CACNB3 with the alpha subunit CACNA1C thereby negatively regulating the activity of the corresponding calcium channel (PubMed:24751537).
messages: Cytoplasm
messages: Detected in brain.
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:7679112, PubMed:10666413, PubMed:24751537, PubMed:29742403, PubMed:15170217). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (PubMed:7679112, PubMed:10666413, PubMed:24751537, PubMed:29742403, PubMed:15170217).

10116:Cdc42ep3
gene id: 10116:Cdc42ep3
uniprot id: A6H9T8
uniprot id: A6H9T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

10116:Gng10
gene id: 10116:Gng10
uniprot id: Q3KRE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: Membrane

10116:Cavin1
gene id: 10116:Cavin1
uniprot id: A6HJ65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

10116:Vom2r35
gene id: 10116:Vom2r35
uniprot id: D3ZUQ5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Pirb
gene id: 10116:Pirb
uniprot id: C0HJX2
uniprot id: C0HJX3
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, including PTPN6/SHP-1, resulting in the dephosphorylation of the downstream protein kinases SYK and BTK.
messages: Interacts with LYN, PTPN6/SHP-1 and PTPN11/SHP-2.
messages: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).
messages: May act as receptor for class I MHC antigens. Becomes activated upon coligation with immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).
messages: Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-697 and Tyr-727 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2.

10116:Rit2
gene id: 10116:Rit2
uniprot id: Q5BJQ5
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP.
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Binds and exchanges GTP and GDP.
messages: Cell membrane
messages: Interacts with AFDN, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Binds calmodulin. Interacts with PLXNB3 (By similarity).
messages: Nucleus
messages: Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.

10116:Ube2v2
gene id: 10116:Ube2v2
uniprot id: Q7M767
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: By angiotensin-II or its agonist CGP42112A, via MTUS1 and PTPN6 (at protein level).
messages: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
messages: Heterodimer with UBE2N. Binds CHFR (By similarity).
messages: Highly expressed in embryonic cerebral cortex, hippocampus and cerebellum between day 18 and up to birth. Levels are distictly lower 10 days after birth, and not detectable in adults (at protein level).

10116:Mthfr
gene id: 10116:Mthfr
uniprot id: A0A8I6A4C5
uniprot id: A0A8I6A5Q6
uniprot id: A6IU40
uniprot id: A6IU41
uniprot id: A6IU43
uniprot id: D4A7E8
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

10116:Eif3j
gene id: 10116:Eif3j
uniprot id: A0JPM9
uniprot id: A6HPR3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

10116:Plk4
gene id: 10116:Plk4
uniprot id: A0A8I6A6C6
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: centriole

10116:Ctsk
gene id: 10116:Ctsk
uniprot id: A6K2Z6
uniprot id: O35186
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Secreted
messages: Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.

10116:Myo1c
gene id: 10116:Myo1c
uniprot id: Q63355
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate (PIP2) or inositol 1,4,5-trisphosphate (InsP3). The PIP2-binding site corresponds to a putative PH domain present in its tail domain.
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Interacts (via its IQ motifs) with CABP1 and CIB1; the interaction with CABP1 and CIB1 is calcium-dependent (By similarity). Interacts (via tail domain) with PLEKHB1 (via PH domain); the interaction is not affected by the presence or absence of calcium and CALM (By similarity). Interacts with POLR1A (By similarity). Interacts with POLR2A (By similarity). Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21 (By similarity). Interacts (via its IQ motifs) with CALM; this precludes interaction with YWHAB (By similarity). Interacts with YWHAB; this precludes interaction with CALM (By similarity). Interacts with RPS6 (By similarity). Interacts with actin (By similarity). Interacts with LLPH (By similarity). Interacts with GLUT4 (PubMed:22918957). Interacts (via its IQ motifs) with SH3BGRL3; the interaction is dependent on calcium and takes place at membrane ruffles (By similarity).
messages: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity).
messages: Nucleus
messages: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).
messages: cell cortex
messages: ruffle membrane
messages: stereocilium membrane

10116:Slc25a47
gene id: 10116:Slc25a47
uniprot id: A6KBH6
uniprot id: Q6J329
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial NAD(+) transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD(+) substrate to mitochondrial SIRT3 deacetylase and enables its NAD(+)-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated.
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

10116:Tmem54
gene id: 10116:Tmem54
uniprot id: Q494T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

10116:Actrt1
gene id: 10116:Actrt1
uniprot id: A6JMN8
uniprot id: Q5XIK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Cytoplasm
messages: Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression.
messages: Nucleus
messages: cytoskeleton

10116:Dok4
gene id: 10116:Dok4
uniprot id: B0BNA8
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

10116:Slco3a1
gene id: 10116:Slco3a1
uniprot id: Q99N02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Basal cell membrane
messages: Basolateral cell membrane
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Expressed in many brain regions, including frontal cortex, brain stem and cerebellum. Associated with neuronal bodies in a punctated matter. Detected at the arcuate nucleus and the choroid plexus (at protein level). Little expression, if any, in oligodendrocytes. In the cardiovascular system, detected in cardiac muscle cells and endothelial cells of aorta, coronary artery and left ventricular endocardium (at protein level). In the respiratory system, detected in alveolar epithelial cells and in mucosal epithelium of the trachea (at protein level). In the reproductive system, detected in spermatozoa, oocytes, smooth muscle cells of the ovary, epithelium of the glandula uterine, smooth muscle cells of the myometrium and epithelium of the endometrium (at protein level). In the kidney, detected in afferent and efferent arterioles, and the epithelium of distal tubules and collecting tubules (at protein level).
messages: Putative organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormone L-thyroxine, prostanoids such as prostaglandin E1 and E2, bile acids such as taurocholate, glycolate and glycochenodeoxycholate and peptide hormones such as L-arginine vasopressin, likely operating in a tissue-specific manner (PubMed:14631946) (By similarity). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable).

10116:Clcnka
gene id: 10116:Clcnka
uniprot id: Q06393
uniprot id: Q66HN9
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily.
messages: Expressed predominantly in the kidney. Expressed strongly in the cortical thick ascending limb and the distal convoluted tubule, with minor expression in the S3 segment of the proximal tubule and the cortical collecting tubule.
messages: Homodimer. Interacts with BSND. Forms heteromers with BSND in the thin ascending limb of Henle (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulated in parallel with BSND under furosemide treatment. Decreased to half in the inner medulla under furosemide treatment. In the renal cortex and outer medulla levels were weak and did not change. Regulation with BSND in inner medulla is limited to the thin limb; levels in collecting ducts were not affected by furosemide treatment. During furosemide treatment selective down-regulation with BSND in thin limb plays a role in maintaining salt and water homeostasis.
messages: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.

10116:Cacna2d3
gene id: 10116:Cacna2d3
uniprot id: Q8CFG5
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calcium channel subunit alpha-2/delta family.
messages: By IGF1.
messages: Dimer formed of alpha-2-2 and delta-2 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity).
messages: In contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug.
messages: In heart, it is expressed in atrium but not in ventricle.
messages: May be proteolytically processed into subunits alpha-2-3 and delta-3 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity).
messages: Membrane
messages: N-glycosylated.
messages: The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.
messages: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity).

10116:Gdf7
gene id: 10116:Gdf7
uniprot id: F1MAE8
names: Similarity
messages: Belongs to the TGF-beta family.

10116:Btf3
gene id: 10116:Btf3
uniprot id: A6I541
uniprot id: F7EZE5
uniprot id: Q5U3Y8
names: Similarity
messages: Belongs to the NAC-beta family.

10116:Cyp2r1
gene id: 10116:Cyp2r1
uniprot id: A6I8B0
names: Similarity
messages: Belongs to the cytochrome P450 family.

10116:Bcl2l11
gene id: 10116:Bcl2l11
uniprot id: A6HQ32
uniprot id: O88498
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Bcl-2 family.
messages: Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1.
messages: Forms heterodimers with a number of antiapoptotic Bcl-2 proteins, including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1, and BCL2L2/BCLW. Does not heterodimerize with proapoptotic proteins such as BAD, BOK or BAK (PubMed:9731710). Identified in a complex containing BCL2L11, DYNLL1 and BCL2L1 isoform Bcl-X(L); BH3 integrity is required for BCL2L1-binding. Interacts with YWHAZ. When phosphorylated, interacts with TRIM2; this interaction is associated with ubiquitination and degradation (PubMed:21478148). Interacts (via BH3) with MCL1; this interaction may sequester BCL2L11 and prevent its pro-apoptotic activity (PubMed:9731710). When phosphorylated, isoform BimEL interacts with USP27X; this interaction leads to BCL2L11 deubiquitination and stabilization (By similarity). Interacts with GIMAP5 (By similarity). Interacts with BCL2L10/BCL-B (By similarity).
messages: Induces apoptosis and anoikis.
messages: Membrane
messages: Mitochondrion
messages: Phosphorylation at Ser-65 by MAPK1/MAPK3 leads interaction with TRIM2 and ubiquitination, followed by proteasomal degradation. Deubiquitination catalyzed by USP27X stabilizes the protein.
messages: Produced by alternative initiation at Met-104 of isoform BOD-L.
messages: The BH3 motif is required for the interaction with Bcl-2 proteins and cytotoxicity.
messages: Ubiquitination by TRIM2 following phosphorylation by MAPK1/MAPK3 leads to proteasomal degradation (PubMed:21478148). Conversely, deubiquitination catalyzed by USP27X stabilizes the protein (By similarity).
messages: Widely expressed.

10116:Tmem33
gene id: 10116:Tmem33
uniprot id: A0A0H2UHA6
uniprot id: A6JDA6
uniprot id: A6JDA7
uniprot id: Q9Z142
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (By similarity). Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling. Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis. Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane (By similarity).
messages: Belongs to the PER33/POM33 family.
messages: Endoplasmic reticulum membrane
messages: Highly expressed in the liver and significantly in brain, lungs and kidneys.
messages: Interacts with EIF2AK3. Interacts with ARL6IP1, isoform RTN1-A of RTN1, isoform RTN2-B of RTN2, isoform 3 of RTN3 and isoform 3 of RTN4. Interacts with RNF5. Interacts with RNF26 (By similarity). Interacts with PKD2 (By similarity).
messages: Melanosome
messages: Membrane
messages: Nucleus envelope

10116:Tas2r138
gene id: 10116:Tas2r138
uniprot id: A0A0G2JST0
uniprot id: Q4VHE7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Expressed in tongue, stomach and duodenum.
messages: Membrane
messages: Putative taste receptor which may play a role in the perception of bitterness.
messages: Several bitter taste receptors are expressed in a single taste receptor cell.

10116:Dynlt4
gene id: 10116:Dynlt4
uniprot id: A6JZC2
uniprot id: G3V8D8
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

10116:Ctsl
gene id: 10116:Ctsl
uniprot id: P07154
names: Activity Regulation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Both mature cathepsin L1 and procathepsin L are found in the upper epidermis. The lower epidermis predominantly contains procathepsin L. In seminiferous tubules expression is greater at stages VI-VII than at stages IX-XII.
messages: Dimer of a heavy and a light chain linked by disulfide bonds. Interacts with Long isoform of CD74/Ii chain; the interaction stabilizes the conformation of mature CTSL.
messages: During export along the endocytic pathway, pro-CTSL undergoes several proteolytic cleavages to generate the CTSL single-chain and two-chain mature forms, composed of a heavy chain linked to a light chain by disulfide bonds (By similarity). Autocleavage; produces the single-chain CTSL after cleavage of the propeptide. The cleavage can be intermolecular (By similarity).
messages: Expression in Sertoli cells is repressed by germ cells.
messages: Inhibited by the propeptide produced by autocleavage (By similarity). Long isoform of CD74/Ii chain stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of APCs. IFNG enhances the conversion into the CTSL mature and active form (By similarity). Inhibited by CST6. Inhibited by the glycopeptide antibiotic teicoplanin. Inhibited by amantadine (By similarity).
messages: Lysosome
messages: Secreted
messages: Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (By similarity). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells. Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 (By similarity). Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (PubMed:7777858).
messages: chromaffin granule
messages: extracellular space

10116:Zup1
gene id: 10116:Zup1
uniprot id: A6K470
uniprot id: Q5U2S3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: C2H2-type zinc finger 4 is a ubiquitin-binding zinc finger (UBZ) and required for polyubiquitin binding, possibly binding the proximal ubiqutin, and for catalytic activity. C2H2-type zinc fingers 1-3 are required for localization to sites of DNA damage.
messages: Cytoplasm
messages: Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress.
messages: Interacts with RPA1 and RPA2.
messages: Nucleus
messages: The motif interacting with ubiquitin (MIU) and ZUFSP ubiquitin-binding domain (zUBD, also called ZUFSP helical arm ZHA) are responsible for binding the distal (outgoing) ubiquitin units S1 and S2 respectively.

10116:Ide
gene id: 10116:Ide
uniprot id: A0A8I6A860
uniprot id: A6I165
uniprot id: P35559
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ATP-binding induces a conformation change.
messages: Activated by ATP, other nucleotide triphosphates and small peptides (PubMed:14527953, PubMed:21731629, PubMed:22049080). Inhibited by bacitracin (PubMed:12941771).
messages: Belongs to the peptidase M16 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Detected in brain (at protein level).
messages: Homodimer. Can also form homotetramers.
messages: Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling (PubMed:1836994, PubMed:1445854, PubMed:10684867, PubMed:12941771, PubMed:14527953, PubMed:22049080). Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (By similarity). Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP (By similarity). Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (PubMed:10684867). Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP (By similarity). Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous patients (By similarity). Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I.
messages: Secreted
messages: The SlyX motif may be involved in the non-conventional secretion of the protein.
messages: cytosol

10116:Ube2g2
gene id: 10116:Ube2g2
uniprot id: A0A8I6GKI1
uniprot id: B2RYD0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

10116:Cfap298
gene id: 10116:Cfap298
uniprot id: Q5U3Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CFAP298 family.
messages: Cytoplasm
messages: Expressed in the trachea (at protein level).
messages: Interacts with ZMYND10.
messages: Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity.
messages: cilium basal body

10116:Akr1c19
gene id: 10116:Akr1c19
uniprot id: A6JLP3
uniprot id: D3ZEL2
names: Similarity
messages: Belongs to the aldo/keto reductase family.

10116:Sec24c
gene id: 10116:Sec24c
uniprot id: A0A0G2K626
uniprot id: B5DEG8
uniprot id: F7ET87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

10116:Smug1
gene id: 10116:Smug1
uniprot id: A6KCZ5
uniprot id: Q811Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus
messages: Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration.

10116:Chn2
gene id: 10116:Chn2
uniprot id: Q03070
names: Activity Regulation
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed specifically in late stage spermatocytes. In the cerebellum, emergence of beta-2 isoform coincides with granule cells maturation and exhibits postnatal developmental increases. Expression is specifically reduced in weaver mutant.
messages: Found in cerebellum and testis.
messages: GTPase-activating protein for p21-rac.
messages: In the inactive state, the N terminus protrudes into the active site of the Rho-GAP domain, sterically blocking Rac binding. Phospholipid binding to the Phorbol-ester/DAG-type zinc-finger/C1 domain triggers the cooperative dissociation of these interactions, allowing the N-terminus to move out of the active site and thereby activating the enzyme (By similarity).
messages: Membrane

10116:Irf6
gene id: 10116:Irf6
uniprot id: A6JH20
uniprot id: D4AAV0
names: Subcellular Location Annotation
messages: Nucleus

10116:Mms19
gene id: 10116:Mms19
uniprot id: M0R6T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

10116:Atp5po
gene id: 10116:Atp5po
uniprot id: A6JLH8
uniprot id: Q06647
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ATPase delta chain family.
messages: Expressed by the principal cells of the epididymis. Detected in flagella of epididymal sperm (at protein level).
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MPL.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

10116:Alk
gene id: 10116:Alk
uniprot id: F1LRZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane

10116:Galnt2
gene id: 10116:Galnt2
uniprot id: A6KJ04
uniprot id: A6KJ05
uniprot id: D3ZFD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

10116:Oma1
gene id: 10116:Oma1
uniprot id: D3ZS74
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autocatalytically cleaved in response to mitochondrial depolarization both at the N-terminus and C-terminus to generate the short active form (S-OMA1). Autocatalytic processing at the C-terminus takes place at residues 426-435. The S-OMA1 form is unstable (By similarity). Degradaded by YMEL1 in response to membrane depolarization (By similarity). Protein turnover is regulated by prohibitin (PHB and PHB2), which promotes degradation of OMA1 in a cardiolipin-binding manner (By similarity).
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.
messages: Homooligomer.
messages: May form a redox-dependent disulfide bond (By similarity). Exists in a semi-oxidized state and is activated by prolonged hypoxia (By similarity).
messages: Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion (By similarity). Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae. In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome. May also cleave UQCC3 in response to mitochondrial depolarization. Also acts as an activator of the integrated stress response (ISR): in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (By similarity). Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Binds cardiolipin, possibly regulating its protein turnover. Required for the stability of the respiratory supercomplexes (By similarity).
messages: Mitochondrion inner membrane
messages: Protease activity is activated upon autocatalytic cleavage in response to mitochondrial depolarization.
messages: The stress-sensor region regulates proteolysis and activation.

10116:Cks1b
gene id: 10116:Cks1b
uniprot id: B2RZ99
uniprot id: B5DER9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

10116:Hnrnpk
gene id: 10116:Hnrnpk
uniprot id: A0A8L2QEP8
uniprot id: A6KAK1
uniprot id: P61980
uniprot id: Q5D059
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Identified in the spliceosome C complex (By similarity). Interacts with ANKRD28 and ZIK1 (By similarity). Interacts with DDX1 (By similarity). Interacts with MDM2; this interaction leads to ubiquitination and proteasomal degradation (By similarity). Interacts with p53/TP53 (By similarity). Interacts with BRDT (By similarity). Interacts with RBM42 (PubMed:19170760). Interacts with IVNS1ABP (By similarity). Interacts with PPIA/CYPA (By similarity). Part of a transcription inhibitory ribonucleoprotein complex composed at least of the circular RNA circZNF827, ZNF827 and HNRNPL (By similarity).
messages: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
messages: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest (By similarity). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity).
messages: Sumoylated by CBX4. Sumoylation is increased upon DNA damage, such as that produced by doxorubicin, etoposide, UV light and camptothecin, due to enhanced CBX4 phosphorylation by HIPK2 under these conditions (By similarity).
messages: Ubiquitinated by MDM2. Doxorubicin treatment does not affect monoubiquitination, but slightly decreases HNRNPK poly-ubiquitination (By similarity).
messages: nucleoplasm
messages: podosome

10116:Mad1l1
gene id: 10116:Mad1l1
uniprot id: A6K1T2
uniprot id: D3ZIV3
names: Similarity
messages: Belongs to the MAD1 family.

10116:Rhbdl3
gene id: 10116:Rhbdl3
uniprot id: A0A8I6AK12
uniprot id: A6HHB1
uniprot id: D4AAW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

10116:Stk3
gene id: 10116:Stk3
uniprot id: F7ER57
uniprot id: O54748
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation. Interacts with and stabilizes SAV1. Interacts with RAF1, which prevents dimerization and phosphorylation. Interacts with RASSF1. Interacts (via SARAH domain) with NEK2. Interacts with ESR1 only in the presence of SAV1. Interacts with PKB/AKT1. Forms a tripartite complex with MOBKL1B and STK38. Interacts with RASSF2 (via SARAH domain). Interacts with DLG5 (via PDZ domain 3). Interacts with LATS1; this interaction is inhibited in the presence of DLG5. Interacts with MARK3 in the presence of DLG5.
messages: Inhibited by the C-terminal non-catalytic region. Activated by caspase-cleavage. Full activation also requires homodimerization and autophosphorylation of Thr-180, which are inhibited by the proto-oncogene product RAF1. Activated by RASSF1 which acts by preventing its dephosphorylation (By similarity).
messages: Nucleus
messages: Phosphorylation at Thr-117 and Thr-384 by PKB/AKT1, leads to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation, and increase in its binding to RAF1.
messages: Proteolytically cleaved by caspase-3 during apoptosis. Proteolytic cleavage results in kinase activation and nuclear translocation of the truncated form (MST1/N) (By similarity).
messages: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates NKX2-1. Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (By similarity).

10116:Septin3
gene id: 10116:Septin3
uniprot id: Q9WU34
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Brain-specific, with highest expression in the hippocampal CA3 region (at protein level).
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).
messages: First expressed in the embryonic brain from 18 dpc. Levels increase during brain development until P7 and remain constant until P35. Further increase in adult brain (at protein level).
messages: Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).
messages: Synapse
messages: cytoskeleton

10116:Mlst8
gene id: 10116:Mlst8
uniprot id: A0A8I5ZL90
uniprot id: A6HCT2
uniprot id: Q9Z2K5
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat LST8 family.
messages: By insulin in adipocytes (at protein level).
messages: Cytoplasm
messages: Expressed at highest levels in the brain and testis, followed by lung, heart, kidney, skeletal muscle, spleen and liver. Also expressed in epididymal, abdominal and brown fat, small intestine and pancreas.
messages: Lysosome membrane
messages: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.
messages: Part of the mechanistic target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8 and RPTOR. mTORC1 associates with AKT1S1/PRAS40, which inhibits its activity. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Within mTORC1, interacts directly with MTOR and RPTOR. Part of the mechanistic target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. mTORC1 and mTORC2 associate with DEPTOR, which regulates its activity. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3. Interacts with SLC38A7; this interaction promotes the recruitment of mTORC1 to the lysosome and its subsequent activation.
messages: Phosphorylation at Thr-51 by CDK1 promotes ubiquitination by the SCF(FBXW7) complex, followed by degradation.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. In response to nutrients, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy. The mTORC1 complex is inhibited in response to starvation and amino acid depletion. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.
messages: Ubiquitination by the SCF(FBXW7) and SCF(FBXW11) complexes following phosphorylation at Thr-51 by CDK1, leads to its degradation by the proteasome.

10116:Atp2b1
gene id: 10116:Atp2b1
uniprot id: A0A8L2QSH6
uniprot id: A6IG74
uniprot id: A6IG75
uniprot id: A6IG76
uniprot id: P11505
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (By similarity). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Cell membrane
messages: Isoform B is ubiquitously expressed. Isoforms A and E have only been found in brain cortex. Isoform C is found in brain cortex, skeletal muscle and heart muscle. Isoform D has only been found in fetal skeletal muscle. Isoform K has been found in small intestine and liver. Isoform B is expressed in hair cells of inner ear (PubMed:16803870).
messages: Isoforms A, C, D and E contain and additional calmodulin-binding subdomain B which is different in the different splice variants and shows pH dependent calmodulin binding properties.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer. Dimer. Oligomer. Calmodulin binding. Interacts with PDZD11. Interacts with SLC35G1 and STIM1. Interacts with YWHAE; interacts with the monomeric and dimeric forms of the YWHAE but prefer the monomer form; this interaction inhibits calcium-transporting ATPase activity (By similarity). Interacts with NPTN; this interaction stabilizes ATP2B1 and increases ATPase activity; this interaction controls T cell calcium homeostasis following T cell activation. Interacts with EPB41; regulates small intestinal calcium absorption through regulation of membrane expression of ATP2B1 (By similarity).
messages: Presynaptic cell membrane
messages: Synapse
messages: synaptic vesicle membrane

10116:Cfap36
gene id: 10116:Cfap36
uniprot id: A0A8I6ATJ2
uniprot id: A6JQB0
uniprot id: Q4V8E4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CFAP36 family.
messages: Cytoplasm
messages: Interacts with ARL3.
messages: May act as an effector for ARL3.
messages: Nucleus
messages: Widely expressed (at protein level).
messages: flagellum

10116:Ncln
gene id: 10116:Ncln
uniprot id: A0A0H2UHD9
uniprot id: A6K875
uniprot id: Q5XIA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nicastrin family.
messages: Component of the back of Sec61 (BOS) complex, composed of NCLN/Nicalin, NOMO1 and TMEM147. The BOS complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO1 and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47). The MPT complex associates with the SEC61 complex.
messages: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity).
messages: Endoplasmic reticulum membrane
messages: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

10116:Lcn8
gene id: 10116:Lcn8
uniprot id: B3EY82
uniprot id: F7FKZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

10116:Smco4
gene id: 10116:Smco4
uniprot id: A6JND3
uniprot id: D4A7S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMCO4 family.
messages: Membrane

10116:Sftpd
gene id: 10116:Sftpd
uniprot id: A6K9M0
uniprot id: P35248
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SFTPD family.
messages: Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
messages: Oligomeric complex of 4 set of homotrimers.
messages: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).
messages: S-nitrosylation at Cys-34 and Cys-39 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.
messages: extracellular matrix
messages: surface film

10116:Faf1
gene id: 10116:Faf1
uniprot id: Q924K2
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Central nervous system.
messages: Interacts with CDT1 and ATPase VCP/p97. Interacts (via UBA domain) with FAS (via death domain). Interacts (via UBA domain) with NLRP12 (via DAPIN/PYRIN domain).
messages: Nucleus
messages: Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but cannot initiate FAS-induced apoptosis.

10116:Aco2
gene id: 10116:Aco2
uniprot id: A6HT25
uniprot id: Q9ER34
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit. Binding of a [3Fe-4S] cluster leads to an inactive enzyme.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers.
messages: Mitochondrion
messages: Monomer.

10116:Or4m1
gene id: 10116:Or4m1
uniprot id: A6KE98
uniprot id: D4A089
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Ccdc174
gene id: 10116:Ccdc174
uniprot id: Q5PQS7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Probably involved in neuronal development.

10116:Wdr76
gene id: 10116:Wdr76
uniprot id: A6HPQ1
uniprot id: D3ZJT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Interacts with CUL4A and/or CUL4B.
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

10116:Irgc
gene id: 10116:Irgc
uniprot id: J7PCJ5
uniprot id: Q6AYF9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

10116:Tmem120b
gene id: 10116:Tmem120b
uniprot id: A6J168
uniprot id: M0R6Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

10116:Or10ak7b
gene id: 10116:Or10ak7b
uniprot id: M0RC25
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Gnb2
gene id: 10116:Gnb2
uniprot id: A6J023
uniprot id: P54313
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat G protein beta family.
messages: Cell membrane
messages: G proteins are composed of 3 units, alpha, beta and gamma. In this context, interacts with GNAI2 and GNG2 (By similarity). Interacts with ARHGEF18 and RASD2. Interacts with ATXN10. Interacts with SCN8A.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: perinuclear region

10116:Or8u10
gene id: 10116:Or8u10
uniprot id: D3ZAV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Chrnb3
gene id: 10116:Chrnb3
uniprot id: A6IVW9
uniprot id: P12391
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-3/CHRNB3 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Neuronal AChR seems to be composed of two different types of subunits: alpha and beta.
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

10116:Mptx1
gene id: 10116:Mptx1
uniprot id: A6JG83
uniprot id: Q6TA48
names: Cofactor
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Expression is restricted to small intestine, stomach and colon. Within colon, expressed in epithelial cells located within the lower to mid region of transverse and distal crypts, but not in proximal colon.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits (By similarity).
messages: Secreted
messages: Strongly down-regulated in colon by dietary heme, or by dietary depletion of vitamin E. Up-regulated by calcium.

10116:Nos2
gene id: 10116:Nos2
uniprot id: Q06518
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: By interferon gamma and lipopolysaccharides (LPS).
messages: Homodimer. Interacts with NHERF1. Interacts with GAPDH; induced by oxidatively-modified low-densitity lipoprotein (LDL(ox)). Interacts with S100A8 and S100A9 to form the iNOS-S100A8/9 transnitrosylase complex. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with ELOC and CUL5 in the presence of SPSB1 or SPSB2 or SPSB4. Forms a complex with ASL, ASS1 and HSP90AA1; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway.
messages: In normal kidney, expressed primarily in the medullary thick ascending limb, with minor amounts in the medullary collecting duct and vasa recta bundle.
messages: Not stimulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity (By similarity).
messages: Polyubiquitinated; mediated by SPSB1, SPSB2 and SPSB4, leading to proteasomal degradation.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8.
messages: Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.
messages: cytosol
messages: sequence Was originally thought to originate from human but appears to be from rat.

10116:Tas2r103
gene id: 10116:Tas2r103
uniprot id: Q67ET5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
messages: Membrane
messages: Several bitter taste receptors with distinct ligand specificities are expressed in a single taste receptor cell.

10116:Pxylp1
gene id: 10116:Pxylp1
uniprot id: Q66H78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histidine acid phosphatase family.
messages: Golgi apparatus membrane
messages: Interacts with B3GAT3; the interaction increases the 2-phosphoxylose phosphatase activity of PXYLP1 during completion of linkage region formation in a B3GAT3-mediated manner.
messages: Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.

10116:Art3
gene id: 10116:Art3
uniprot id: F7EXX0
uniprot id: Q6AYJ9
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

10116:Chst3
gene id: 10116:Chst3
uniprot id: Q9QZL2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Golgi apparatus membrane
messages: N-glycosylated.
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Catalyzes with a lower efficiency the sulfation of Gal residues of keratan sulfate, another glycosaminoglycan (By similarity). Can also catalyze the sulfation of the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides (By similarity). May play a role in the maintenance of naive T-lymphocytes in the spleen (By similarity).

10116:Fos
gene id: 10116:Fos
uniprot id: P12841
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. Fos subfamily.
messages: Constitutively sumoylated with SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-232 (By similarity).
messages: Endoplasmic reticulum
messages: Heterodimer; with JUN (By similarity). Component of the SMAD3/SMAD4/JUN/FOS complex required for synergistic TGF-beta-mediated transcription at the AP1-binding site (By similarity). Interacts with SMAD3; the interaction is weak even on TGF-beta activation (By similarity). Interacts with MAFB (PubMed:9571165). Interacts with TSC22D3 (via N-terminus); this interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with CDS1 and PI4K2A (By similarity). Interacts (via bZIP domain and leucine-zipper region) with the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF) subunits SMARCB1, SMARCC2 and SMARCD1 (By similarity). Interacts (via bZIP domain and leucine-zipper region) with ARID1A (By similarity).
messages: In quiescent cells, the small amount of FOS present is phosphorylated at Tyr-10 and Tyr-30 by SRC. This Tyr-phosphorylated form is cytosolic. In growing cells, dephosphorylated by PTPN2. Dephosphorylation leads to the association with endoplasmic reticulum membranes and activation of phospholipid synthesis (By similarity).
messages: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).
messages: Nucleus
messages: Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF) (By similarity). Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232, induced by HA-RAS, activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to osteoblast transformation.
messages: cytosol

10116:B3galt2
gene id: 10116:B3galt2
uniprot id: A6ICN8
uniprot id: D4A950
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

10116:Jdp2
gene id: 10116:Jdp2
uniprot id: Q78E65
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1, such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin (By similarity).
messages: Interacts with IRF2BP1 (By similarity). Forms homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG (By similarity). Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer.
messages: Nucleus
messages: Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments.
messages: Polyubiquitinated; probably by IRF2BP1.

10116:Ms4a4c
gene id: 10116:Ms4a4c
uniprot id: A6I094
uniprot id: D4A8R9
names: Similarity
messages: Belongs to the MS4A family.

10116:Sgcb
gene id: 10116:Sgcb
uniprot id: A6JD29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.
messages: cytoskeleton
messages: sarcolemma

10116:Alg13
gene id: 10116:Alg13
uniprot id: A6KG91
uniprot id: Q5I0K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 28 family.
messages: Endoplasmic reticulum
messages: May be involved in protein N-glycosylation, second step of the dolichol-linked oligosaccharide pathway.
messages: May interact with ALG14.

10116:Acss1
gene id: 10116:Acss1
uniprot id: A6KHF6
uniprot id: D3ZZN3
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

10116:Scaf1
gene id: 10116:Scaf1
uniprot id: Q63624
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Interacts with POLR2A.
messages: May function in pre-mRNA splicing.
messages: Nucleus

10116:Nrp2
gene id: 10116:Nrp2
uniprot id: A0A8I6AF12
uniprot id: A0A8I6AH16
uniprot id: A0A8L2UM12
uniprot id: O35276
names: Caution
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the neuropilin family.
messages: Found in certain neuronal populations of the CNS, including dorsal root ganglia, and in other non-neuronal tissues including mesenchymal tissue lining in the ribs.
messages: Heterodimer with NRP1. Binds PLXNB1 (By similarity).
messages: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
messages: Increased in dorsal root ganglia in response to injury caused by dorsal rhizotomy (PubMed:28270793). Increased in dorsal root ganglia in response to sciatic transection injury (PubMed:28270793). Transiently increased in dorsal root ganglia in response to sciatic nerve crush injury, returning to comparable levels 42 days post-injury (PubMed:28270793).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.

10116:Eif4ebp1
gene id: 10116:Eif4ebp1
uniprot id: Q62622
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the eIF4E-binding protein family.
messages: Cytoplasm
messages: Expressed in all tissues examined; highest levels in fat and skeletal tissue, lowest levels in kidney.
messages: Hypophosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) or mTORC1 phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation (PubMed:7939721). Interacts (via TOS motif) with RPTOR; promoting phosphorylation by mTORC1 (By similarity).
messages: Nucleus
messages: Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-36, Thr-45, Ser-64 and Thr-69, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E.
messages: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (PubMed:7939721).
messages: The TOS motif mediates interaction with RPTOR, leading to promote phosphorylation by mTORC1 complex.
messages: Ubiquitinated: when eIF4E levels are low, hypophosphorylated form is ubiquitinated by the BCR(KLHL25) complex, leading to its degradation and serving as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. Not ubiquitinated when hyperphosphorylated (at Thr-36, Thr-45, Ser-64 and Thr-69) or associated with eIF4E.

10116:Egr1
gene id: 10116:Egr1
uniprot id: P08154
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers. The first, most N-terminal zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine.
messages: By growth factors (PubMed:2492104). Rapidly and transiently up-regulated in response to ischemia (PubMed:1859855).
messages: Cytoplasm
messages: Detected in kidney thick ascending limbs and collecting ducts (at protein level).
messages: Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction.
messages: Nucleus
messages: Transcriptional regulator (PubMed:8413279). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (PubMed:15220929). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity). Regulates biosynthesis of glucocorticoid receptor GR/NR3C1 in the hippocampus and thereby may play a role in the behavioral and hypothalamic-pituitary-adrenal responses to stress in offspring (PubMed:15220929).

10116:Olr1309
gene id: 10116:Olr1309
uniprot id: A6J3M8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

10116:Cdk11b
gene id: 10116:Cdk11b
uniprot id: D3ZML3
uniprot id: D4A3G2
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

10116:Foxj1
gene id: 10116:Foxj1
uniprot id: Q63247
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FOXJ1 family.
messages: Nucleus
messages: Pulmonary epithelium, testis and oviduct.
messages: Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). Activates the transcription of a variety of ciliary proteins in the developing brain and lung.

10116:Or56b6
gene id: 10116:Or56b6
uniprot id: A0A8I6G1Y6
names: Subcellular Location Annotation
messages: Membrane

10116:Stfa3
gene id: 10116:Stfa3
uniprot id: A6IRD0
uniprot id: P01039
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Cytoplasm
messages: This is an intracellular thiol proteinase inhibitor.

10116:Gcnt3
gene id: 10116:Gcnt3
uniprot id: A6KEU3
uniprot id: Q8CH87
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 14 family.
messages: Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.
messages: Golgi apparatus membrane
messages: Membrane
messages: N-glycosylated.

10116:Rheb
gene id: 10116:Rheb
uniprot id: Q62639
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Inactivated by the TSC-TBC complex via the GTPase activating protein (GAP) domain of TSC2.
messages: Associates with the mTORC1 complex (MTOR, MLST8 and RPTOR) in a guanyl nucleotide-independent manner. Interacts with TSC2. Interacts (when prenylated) with PDE6D; this promotes release from membranes (By similarity). Autoinhibited by Tyr-35, which constrains the active site conformation, restricting the access of the catalytic Asp-65 to the nucleotide-binding pocket (By similarity).
messages: Belongs to the small GTPase superfamily. Rheb family.
messages: Endomembrane system
messages: Endoplasmic reticulum membrane
messages: Expressed at high levels in normal adult cortex as well as a number of peripheral tissues, including lung and intestine.
messages: Farnesylation is important for efficiently activating mTORC1-mediated signaling.
messages: Golgi apparatus membrane
messages: Lysosome membrane
messages: Phosphorylation by MAPKAPK5 impairs GTP-binding and inactivation.
messages: Polyubiquitinated in response to amino acid, promoting its interaction with MTOR and mTORC1 activation. Deubiquitination by ATXN3 promotes recruitment of the TSC-TBC complex and RHEB inactivation by TSC2. Monoubiquitinated at Lys-8 by RNF152, promoting its association with the TSC-TBC complex. Deubiquitinated at Lys-8 by USP4, promoting mTORC1 activation.
messages: Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes. In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1. Has low intrinsic GTPase activity.
messages: The conserved catalytic Gln-64 found in other Ras-like GTPases seems not to be involved in GTP hydrolysis in RHEB.
messages: cytosol

10116:Slain1
gene id: 10116:Slain1
uniprot id: Q5HZW0
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

10116:Cpm
gene id: 10116:Cpm
uniprot id: A6IGT0
uniprot id: D4A9Q5
names: Similarity
messages: Belongs to the peptidase M14 family.

10116:Nfib
gene id: 10116:Nfib
uniprot id: A0A8I6AFY4
uniprot id: O70186
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

10116:Chac1
gene id: 10116:Chac1
uniprot id: B3STU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos.
messages: Interacts with NOTCH1 (via extracellular region).
messages: cytosol
messages: trans-Golgi network

10116:Il4r
gene id: 10116:Il4r
uniprot id: A6I914
uniprot id: Q63257
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
messages: Isoform 2 (soluble form) inhibits IL4-induced spleen cell proliferation.
messages: Isoform 2 is expressed in kidney, spleen, lung and liver.
messages: On IL4 binding, phosphorylated on C-terminal tyrosine residues.
messages: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity).
messages: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
messages: Secreted
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3. Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP. Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4 signaling. Interacts with JAK3. Interacts with CLM1.

10116:Ebf3
gene id: 10116:Ebf3
uniprot id: A6HX79
uniprot id: D4A274
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

10116:Axin1
gene id: 10116:Axin1
uniprot id: A0A8I5ZVQ9
uniprot id: A6HD90
uniprot id: O70239
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway (By similarity).
messages: Cell membrane
messages: Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (By similarity). Also facilitates the phosphorylation of APC by GSK3B (By similarity). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (By similarity). Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity).
messages: Cytoplasm
messages: Highly expressed in testis, thymus and lung. Less expression in cerebrum, cerebellum, heart, kidney, skeletal muscle, spleen and liver.
messages: Homodimer (By similarity). Interacts with ZBED3; the interaction is direct, enhanced by protein kinase GSK3B and casein kinase CSNK1E activities and decreases GSK3B-induced beta-catenin serine and threonine phosphorylations (By similarity). Component of the AXIN1-HIPK2-TP53 complex (By similarity). Interacts directly in the complex with TP53 and HIPK2 (By similarity). Interacts with DAXX; the interaction stimulates the interaction of DAXX with TP53, stimulates 'Ser-46' phosphorylation of TP53 and induces cell death on UV irradiation (By similarity). Also binds ANKRD6, PIAS1, PIAS2, PIAS4, MAP3K1, MAP3K4, SUMO1, SMAD6, SMAD7 and RNF111 (By similarity). Interacts with DIXDC1; the interaction prevents interaction with MAP3K1 (By similarity). Interacts with MDFI; the interaction decreases AXIN1-mediated JUN N-terminal kinase (JNK) activation (By similarity). Interacts with MDFIC; the interaction inhibits beta-cateninin-mediated signaling and AXIN1-mediated JUN N-terminal kinase (JNK) activation (By similarity). Interacts with LRP5 (via its phosphorylated PPPSP motifs); the interaction is stimulated by WNT1 and GSK3B and activates beta-catenin signaling (By similarity). Interacts (via the C-terminal) with PPP1CA; the interaction dephosphorylates AXIN1 and regulates interaction with GSK3B (By similarity). Interacts with PPP2CA; the interaction dephosphorylates AXIN1 (By similarity). Component of the beta-catenin destruction complex, containing at least, CTNNB1, an axin and GSK3B, that regulates CTNNB1 protein levels through phosphorylation and ubiquitination (By similarity). Interacts with CTNNB1 (via the armadillo repeats 2-7) (By similarity). Interacts with GSK3B; the interaction hyperphosphorylates CTNNB1 leading to its ubiquitination and destruction (PubMed:9482734, PubMed:16815997). Interacts with MACF1 (PubMed:16815997). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (PubMed:16815997). Interacts with TNKS (By similarity). Interacts with DAB2; the…
messages: Membrane
messages: Nucleus
messages: Phosphorylation and dephosphorylation of AXIN1 regulates assembly and function of the beta-catenin complex. Phosphorylated by CK1 and GSK3B. Dephosphorylated by PPP1CA and PPP2CA. Phosphorylation by CK1 enhances binding of GSK3B to AXIN1. Also phosphorylated by CDK2 which regulates interaction with CTNBB1 (By similarity).
messages: The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2.
messages: Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Sumoylation at Lys-858 and Lys-861 prevents ubiquitination and degradation. Sumoylation is required for AXIN1-mediated JNK activation. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important for nuclear accumulation during Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription (By similarity). Ubiquitination by SIAH1 and SIAH2 induces its proteasomal degradation as part of the activation of the Wnt signaling pathway (By similarity).

10116:Snrpa
gene id: 10116:Snrpa
uniprot id: A0A9K3Y6T2
uniprot id: Q5U214
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM U1 A/B'' family.
messages: Nucleus

10116:Calm3
gene id: 10116:Calm3
uniprot id: P0DP29
uniprot id: P0DP30
uniprot id: P0DP31
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calmodulin family.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Is a regulator of voltage-dependent L-type calcium channels. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding. Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2.
messages: Interacts with CEP97, CCP110, TTN/titin and SRY (By similarity). Interacts with MYO5A and RRAD (PubMed:18056528). Interacts with USP6; the interaction is calcium dependent (By similarity). Interacts with CDK5RAP2 (By similarity). Interacts with SCN5A (By similarity). Interacts with RYR1 (By similarity). Interacts with FCHO1 (By similarity). Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure (By similarity). Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (By similarity). Interacts with SYT7 (By similarity). Interacts with MYO10 and MYO1C (By similarity). Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (PubMed:8576129). Interacts with RYR2; regulates RYR2 calcium-release channel activity (By similarity). Interacts with PCP4; regulates calmodulin calcium-binding (By similarity). Interacts with the heterotetrameric KCNQ2 and KCNQ3 channel; the interaction is calcium-independent, constitutive and participates in the proper assembly of a functional heterotetrameric M channel (By similarity).
messages: Interacts with CEP97, CCP110, TTN/titin and SRY (By similarity). Interacts with MYO5A and RRAD (PubMed:18056528). Interacts with USP6; the interaction is calcium dependent (By similarity). Interacts with CDK5RAP2 (By similarity). Interacts with SCN5A (By similarity). Interacts with RYR1 (By similarity). Interacts with FCHO1 (By similarity). Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure (By similarity). Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (PubMed:23109337). Interacts with SYT7 (By similarity). Interacts with MYO10 and MYO1C (By similarity). Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (PubMed:8576129). Interacts with RYR2; regulates RYR2 calcium-release channel activity (By similarity). Interacts with PCP4; regulates calmodulin calcium-binding (By similarity). Interacts with the heterotetrameric KCNQ2 and KCNQ3 channel; the interaction is calcium-independent, constitutive and participates in the proper assembly of a functional heterotetrameric M channel (By similarity). Interacts with SLC9A1 in a calcium-dependent manner (By similarity). In the absence of Ca(+2), interacts with GIMAP4 (via IQ domain) (By similarity). Interacts with SCN8A; the interaction modulates the inactivation rate of SCN8A (By similarity). Interaction with KIF1A; the interaction is increased in presence of calcium and increases neuronal dense core vesicles motility (PubMed:30021165). Interacts with KCNN3 (By similarity). Interacts with KCNQ1 (via C-terminus); forms a heterooctameric structure (with 4:4 KCNQ1:CALM stoichiometry) in a calcium-independent manner (By similarity). Interacts with PIK3C3; the interaction modulates PIK3C3 kinase activity (By similarity). Interacts with HINT1; interaction increases in the presen…
messages: Phosphorylation results in a decreased activity.
messages: The N-terminal and C-terminal lobes of CALM bind to the C-terminus of KCNQ1 in a clamp-like conformation. Binding of CALM C-terminus to KCNQ1 is calcium-independent but is essential for assembly of the structure. Binding of CALM N-terminus to KCNQ1 is calcium-dependent and regulates electrophysiological activity of the channel.
messages: This protein has four functional calcium-binding sites.
messages: Ubiquitination results in a strongly decreased activity.
messages: centrosome
messages: flagellum
messages: spindle
messages: spindle pole

10116:Gpm6b
gene id: 10116:Gpm6b
uniprot id: A0A0G2JZB8
uniprot id: A0A8I6A9L3
uniprot id: A6K2I4
uniprot id: A6K2I6
uniprot id: A6K2I7
uniprot id: A6K2J0
uniprot id: Q9JJK1
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the myelin proteolipid protein family.
messages: By hypercapnic stimulation (CO2 inhalation) in ventral medullary surface neurons but not in the cerebral cortex.
messages: Cell membrane
messages: Highly expressed in the ventral medullary surface, moderately in the cerebral cortex and cerebellum, poorly in lung and kidney, and not at all in heart, skeletal muscle, liver, stomach or stomach.
messages: In the developing brain, expression begins by at least embryonic day 20, increases gradually through postnatal day 2 and day 50 and decreases by postnatal day 300.
messages: Interacts with SERT.
messages: May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.
messages: Membrane

10116:Rpap3
gene id: 10116:Rpap3
uniprot id: Q68FQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RPAP3 family.
messages: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.
messages: Tightly associated with the RNA polymerase II complex (By similarity). Component of the R2TP complex composed at least of RUVBL1, RUVBL2, RPAP3 and PIHD1 (By similarity). Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92 (By similarity). Interacts with PIH1D1 (By similarity). Interacts with TSC1 and TSC2 (By similarity). Interacts with PRPF8 and EFTUD2 in a ZNHIT2-dependent manner (By similarity).

10116:Nr0b2
gene id: 10116:Nr0b2
uniprot id: A6ISX4
uniprot id: P97947
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Detected in kidney, testis, heart and liver.
messages: Heterodimer; efficient DNA binding requires dimerization with another bHLH protein (By similarity). Interacts (via N-terminus) with NEUROD1 (via N-terminus and C-terminus) (By similarity). Interacts with ID2 (By similarity). Interacts with NR1I3 and EID1 (By similarity). Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, PPARA and PPARG (PubMed:9003453, PubMed:15976031, PubMed:15721253). Interacts with RORG, NFIL3, NR1D1 and BHLHE41 (By similarity). Interacts with HNF4A; the resulting heterodimer is transcriptionnally inactive (By similarity). Interacts with DDX3X; this interaction disrupts the interaction between HNF4 and NR0B2/SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers (By similarity).
messages: Nucleus
messages: Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (By similarity). Specifically inhibits transactivation of the nuclear receptor with which it interacts (By similarity). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (By similarity). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (By similarity).

10116:Vwa2
gene id: 10116:Vwa2
uniprot id: D4A0J4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:F8
gene id: 10116:F8
uniprot id: Q7TN96
names: Similarity
messages: Belongs to the multicopper oxidase family.

10116:Syt4
gene id: 10116:Syt4
uniprot id: P50232
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the synaptotagmin family.
messages: Interacts with KIF1A; the interaction increases in presence of calcium and decreases when SYT4 is phosphorylated at Ser-135.
messages: Phosphorylation at Ser-135 by MAPK8/JNK1 reduces interaction with KIF1A and neuronal dense core vesicles mobility.
messages: Synaptotagmin family member which does not bind Ca(2+) (PubMed:7993622). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses (PubMed:29166604). Plays a role in dendrite formation by melanocytes (By similarity).
messages: Unlike in other synaptotagmin family members, the first C2 domain/C2A does not bind Ca(2+) neither mediates Ca(2+)-dependent phospholipid binding. An aspartate-to-serine substitution in this domain inactivates Ca(2+)/phospho-lipid binding.
messages: Up-regulated by potassium depolarization, calcium ionophore, ATP and forskolin in culture cells (PubMed:7892240). Up-regulated by kainate in the hippocampus and piriform cortex (PubMed:7892240).
messages: Widely expressed (PubMed:7892240). Expressed in the brain (PubMed:7892240). Expressed in pituitary gland, cerebellum, cortex, hypothalamus and hippocampus (PubMed:7892240).
messages: neuronal dense core vesicle membrane

10116:Spns3
gene id: 10116:Spns3
uniprot id: A0A8I5ZPL7
uniprot id: A6HGG1
uniprot id: A6HGG2
uniprot id: D3ZCZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

10116:Phc2
gene id: 10116:Phc2
uniprot id: A6ISF6
uniprot id: D4A0M3
names: Subcellular Location Annotation
messages: Nucleus

10116:Kdelr3
gene id: 10116:Kdelr3
uniprot id: F1LPB5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Cmtm5
gene id: 10116:Cmtm5
uniprot id: A6KGX8
names: Subcellular Location Annotation
messages: Membrane

10116:Gramd1a
gene id: 10116:Gramd1a
uniprot id: A0A8I6GIR6
uniprot id: Q3KR56
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome. This function in autophagy requires its cholesterol-transfer activity (By similarity).
messages: Endoplasmic reticulum membrane
messages: Expressed at a significantly higher level in postnatal day 1 (PND1) than in PND21 visual cortical.
messages: GRAM domain binds phosphatidylserine in the PM and mediates protein recruitment to endoplasmic reticulum-plasma membrane contact sites (EPCS) in response to excess cholesterol in the PM.
messages: Membrane
messages: VASt (VAD1 Analog of StAR-related lipid transfer) domain, also known as ASTER (Greek for star) domain is a sterol-binding domain.
messages: autophagosome

10116:Cadps
gene id: 10116:Cadps
uniprot id: Q62717
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering.
messages: Interacts with the dopamine receptor DRD2 (By similarity). Interacts with RASL10B (By similarity). Homodimer.
messages: Specifically expressed in neural and endocrine secretory tissues. Expressed in brain, pancreas, hypothalamus, pituitary and adrenal but not in heart, placenta, lung, liver, skeletal muscle or kidney. In brain, it is absent from the cell body layers of the hippocampus and dentate gyrus but abundant in the synaptic neuropil, except for the stratum lucidum and stratum lacunosum moleculare where it is not detected. In the cerebellum, it is mainly detected in the glomeruli of the granule cell layer where it colocalized with synaptophysin. In the olfactory bulb, it is detected mainly in the glomeruli. In the adult adrenal gland, where it is restricted to the medulla (at protein level).
messages: Synapse
messages: The PH domain is essential for regulated exocytosis and binds phospholipids and plasma membrane. It however does not mediate binding to DCVs.
messages: neuronal dense core vesicle membrane

10116:Or51a10
gene id: 10116:Or51a10
uniprot id: D3ZLN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Emg1
gene id: 10116:Emg1
uniprot id: A6ILJ1
uniprot id: D3ZDS4
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

10116:Sf1
gene id: 10116:Sf1
uniprot id: F1LM37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

10116:Il5ra
gene id: 10116:Il5ra
uniprot id: G3V6S7
uniprot id: Q99PS3
names: Subcellular Location Annotation
messages: Membrane

10116:Foxc1
gene id: 10116:Foxc1
uniprot id: A0A8I6GKJ4
names: Subcellular Location Annotation
messages: Nucleus

10116:Alg8
gene id: 10116:Alg8
uniprot id: Q497D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:Pdgfd
gene id: 10116:Pdgfd
uniprot id: A6JN21
uniprot id: Q9EQT1
names: Caution
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form (By similarity).
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis (By similarity). May play an important role in control of lens epithelial cell proliferation. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix.
messages: Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Not detected in the spinal cord at 21 dpc. Expressed weakly at postnatal day 1 (P1) and a strong expression seen at P21 and this continues into adulthood.
messages: Secreted
messages: Widely expressed. Expressed at high levels in the kidney, adrenal glands, eye and CNS. In the kidney the localization is confined to arterial and arteriolar vascular smooth muscle cells and is also detected at low levels in the glomeruli In the eye in the anterior segment it is localized to the iris and ciliary body. In the retina localizes intensely to the outer plexiform layer, which contains photoreceptor axons and the synaptic layer between photoreceptors and second order neurons. In the spinal cord, prominently expressed in the motorneurons.

10116:Samhd1
gene id: 10116:Samhd1
uniprot id: D3Z898
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAMHD1 family.
messages: Chromosome

10116:Serpinb8
gene id: 10116:Serpinb8
uniprot id: A6JSW1
uniprot id: D3ZHB5
names: Similarity
messages: Belongs to the serpin family.

10116:Mtx2
gene id: 10116:Mtx2
uniprot id: A0A8I5ZLV1
uniprot id: F7FAZ7
uniprot id: Q5U1Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

10116:Lancl2
gene id: 10116:Lancl2
uniprot id: Q68FQ9
names: Similarity
messages: Belongs to the LanC-like protein family.

10116:Csnk1g3
gene id: 10116:Csnk1g3
uniprot id: A6IX39
uniprot id: Q62763
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
messages: Cytoplasm
messages: Expressed in testis, brain, heart, kidney, lung, liver and muscle.
messages: Monomer.
messages: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).
messages: Triazolodiamine 1 is a commercial name for 5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide.

10116:Calb1
gene id: 10116:Calb1
uniprot id: A6IIA7
uniprot id: P07171
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
messages: Interacts with RANBP9.
messages: This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.

10116:Ifng
gene id: 10116:Ifng
uniprot id: A0A7R8C3J6
uniprot id: P01581
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer.
messages: Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization.
messages: Released primarily from activated T lymphocytes.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.

10116:Arg2
gene id: 10116:Arg2
uniprot id: O08701
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Homotrimer.
messages: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity.
messages: Mitochondrion

10116:Trmt1l
gene id: 10116:Trmt1l
uniprot id: A6ICS6
uniprot id: Q496Z9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: May play a role in motor coordination and exploratory behavior.

10116:Sec13
gene id: 10116:Sec13
uniprot id: A6IBU1
uniprot id: Q5XFW8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as a E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex.
messages: At the nuclear pore: component of the Y-shaped Nup107-160 subcomplex of the nuclear pore complex (NPC) (By similarity). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13 (By similarity). At the COPII coat complex: interacts with SEC31A and SEC31B (PubMed:10788476). Interacts with SEC16A (By similarity). Interacts with SEC16B (By similarity). Component of the GATOR2 subcomplex, composed of MIOS, SEC13, SEH1L, WDR24 and WDR59 (By similarity). The GATOR2 complex interacts with CASTOR1 and CASTOR2; the interaction is negatively regulated by arginine (By similarity). The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids (By similarity).
messages: Belongs to the WD repeat SEC13 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity).
messages: Lysosome membrane
messages: The GATOR2 complex is negatively regulated by the upstream amino acid sensors CASTOR1 and SESN2, which sequester the GATOR2 complex in absence of amino acids. In the presence of abundant amino acids, GATOR2 is released from CASTOR1 and SESN2 and activated.
messages: nuclear pore complex

10116:Brpf1
gene id: 10116:Brpf1
uniprot id: D4A411
names: Subcellular Location Annotation
messages: Nucleus

10116:Nrbf2
gene id: 10116:Nrbf2
uniprot id: Q9QYK3
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NRBF family.
messages: Cytoplasm
messages: Detected in spleen, lung, muscle, liver, kidney, heart, testis and brain.
messages: Expressed at 14.5 dpc in cerebral cortex; expression increases over time in cultured neural stem/progenitor cells.
messages: Interacts with PPARD and PPARG (By similarity). Interacts with SCOC (By similarity). Interacts with PPARA. Interacts with THRB, RARA, RARG and RXRA in the presence of bound ligand. Associates with the PI3K complex I (PI3KC3-C1); the direct binding partner in the complex is reported variably as PIK3R4 or ATG14 (By similarity).
messages: Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation (By similarity).
messages: May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).
messages: Nucleus
messages: autophagosome

10116:Mcur1
gene id: 10116:Mcur1
uniprot id: A6J744
names: Similarity
messages: Belongs to the CCDC90 family.

10116:Or5m3
gene id: 10116:Or5m3
uniprot id: A6HMV9
uniprot id: D3ZQI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Or5ac19
gene id: 10116:Or5ac19
uniprot id: A0A8I6A9B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Slc10a6
gene id: 10116:Slc10a6
uniprot id: Q70EX6
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Glycosylated.
messages: Highly expressed in heart, lung, spleen and adrenal gland. Moderately expressed in skeletal muscle, testis and small intestine.
messages: In humans, 3-beta-sulfooxy-androst-5-en-17-one (DHEAS) is the most abundant circulating steroid sulfate in the human body, it is mainly synthesized from adrenal glands and gonads, whereas rats and mice have low circulating concentrations of DHEAS in the periphery as they can only produce DHEAS in their gonads.
messages: Membrane
messages: Transports sulfoconjugated steroid hormones from the extracellular compartment into the cytosol in a sodium-dependent manner without hydrolysis (PubMed:15020217). Steroid sulfate hormones are commonly considered to be biologically inactive metabolites, that may be activated by steroid sulfatases into free steroids (By similarity). May play an important role by delivering sulfoconjugated steroids to specific target cells in reproductive organs (By similarity). May play a role transporting the estriol precursor 16alpha-hydroxydehydroepiandrosterone 3-sulfate (16a-OH-DHEAS) at the fetal blood vessel endothelium (By similarity). Can also transport other sulfoconjugated molecules such as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes (By similarity).

10116:Nxf7
gene id: 10116:Nxf7
uniprot id: Q498M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: nucleoplasm

10116:Rnase13
gene id: 10116:Rnase13
uniprot id: Q5GAL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Does not exhibit any ribonuclease activity.
messages: Secreted

10116:RGD1564306
gene id: 10116:RGD1564306
uniprot id: F1LWL9
names: Similarity
messages: Belongs to the KHDC1 family.

10116:Anxa3
gene id: 10116:Anxa3
uniprot id: A6K668
uniprot id: P14669
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Inhibitor of phospholipase A2, also possesses anti-coagulant properties.

10116:LOC103690888
gene id: 10116:LOC103690888
uniprot id: D3Z9F6
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

10116:Mogat1
gene id: 10116:Mogat1
uniprot id: A6JW64
uniprot id: D4A6J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

10116:Ddx10
gene id: 10116:Ddx10
uniprot id: A6J4I8
uniprot id: D3ZBY5
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

10116:Or11l3
gene id: 10116:Or11l3
uniprot id: A6HEU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Syt5
gene id: 10116:Syt5
uniprot id: P47861
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: Expressed in kidney, adipose tissue, lung and heart, as well as at higher levels in brain.
messages: Homodimer (By similarity). Interacts with both alpha- and beta-tubulin (PubMed:12966166).
messages: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface.
messages: Recycling endosome membrane
messages: synaptic vesicle membrane

10116:Rab9b
gene id: 10116:Rab9b
uniprot id: A6KNU6
uniprot id: D3ZP15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

10116:A2m
gene id: 10116:A2m
uniprot id: P06238
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: By inflammatory stimulus in liver. The level of this protein increases during acute phase, then decreases again.
messages: Highest constitutive expression in ovary. Low level in testis, uterus and non-acute phase liver. Protein found in plasma.
messages: Homotetramer; disulfide-linked.
messages: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
messages: Secreted

10116:Itih1
gene id: 10116:Itih1
uniprot id: B2RYM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

10116:Rgn
gene id: 10116:Rgn
uniprot id: A6JZT8
uniprot id: Q03336
names: Cofactor
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SMP-30/CGR1 family.
messages: Binds 1 divalent metal cation per subunit. Most active with Zn(2+) and Mn(2+) ions. The physiological cofactor for gluconolactonase activity is most likely Ca(2+) or Mg(2+). Mg(2+), Mn(2+) and Co(2+) are equally efficient for the hydrolysis of diisopropyl phosphorofluoridate.
messages: Cytoplasm
messages: Detected in liver (at protein level). Hepatocytes and renal proximal tubular epithelium.
messages: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities.
messages: In liver, the first peak of expression was found in 5-day-old neonates. Expression increases from day 7 and reaches a plateau at day 10. 3-6.5 moth-old adults express about a third the amount of neonates level. In kidney, expression increases from day 21 and reaches a maximal level at day 35, remains high until 3 months of age.
messages: Monomer.
messages: The N-terminus is blocked.

10116:Cpsf7
gene id: 10116:Cpsf7
uniprot id: Q5XI29
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Asymmetrically dimethylated on arginine residues by PRMT1.
messages: Belongs to the RRM CPSF6/7 family.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF7 activates directly the mRNA 3'-processing machinery. Binds to pA signals in RNA substrates.
messages: Component of the cleavage factor Im (CFIm) complex which is a heterotetramer composed of two subunits of NUDT21/CPSF5 and two subunits of CPSF6 or CPSF7 or a heterodimer of CPSF6 and CPSF7. The cleavage factor Im (CFIm) complex associates with the CPSF and CSTF complexes to promote the assembly of the core mRNA 3'-processing machinery. Interacts with NUDT21/CPSF5. Interacts (via Arg/Ser-rich domain) with FIP1L1 (preferentially via unphosphorylated form and Arg/Glu/Asp-rich region); this interaction mediates, at least in part, the interaction between the CFIm and CPSF complexes and may be inhibited by CPSF7 hyper-phosphorylation.
messages: Contains an Arg/Ser-rich domain composed of arginine-serine dipeptide repeats within the C-terminal region that is necessary and sufficient for activating mRNA 3'-processing.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated.

10116:Ehd2
gene id: 10116:Ehd2
uniprot id: A6J888
uniprot id: Q4V8H8
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane.
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Homodimer and homooligomer. Interacts with EHD1. May also interact with EHD3 and EHD4. Interacts with MYOF. Interacts with EHBP1. Interacts with FER1L5 (via second C2 domain). Interacts with CAV1 in a cholesterol-dependent manner. Interacts (via EH domain) with PACSIN2 (via NPF motifs); this interaction probably stabilizes the caveolae (By similarity).
messages: Membrane
messages: The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.
messages: The very low intrinsic ATPase activity is increased upon interaction with liposomes.
messages: caveola
messages: cytosol

10116:Tmem214
gene id: 10116:Tmem214
uniprot id: A1L1L2
uniprot id: A6HAC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM214 family.
messages: Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.
messages: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress (By similarity).
messages: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:Npffr2
gene id: 10116:Npffr2
uniprot id: A6KKH0
uniprot id: Q9EQD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

10116:Entr1
gene id: 10116:Entr1
uniprot id: A0A0G2JTN0
uniprot id: A0A8I6A2U5
uniprot id: A0A8I6AUN1
uniprot id: F1LMK3
names: Similarity
messages: Belongs to the ENTR1 family.

10116:Rab11a
gene id: 10116:Rab11a
uniprot id: P62494
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cleavage furrow
messages: Cytoplasmic vesicle membrane
messages: Detected in various tissues, such as brain, testis, spleen, and heart.
messages: Endosome membrane
messages: Golgi apparatus
messages: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4 (By similarity). Forms a complex with RAB11FIP3 and dynein intermediate chain DYNC1LI1; the interaction between RAB11A1 and RAB11FIP3 is direct; the complex regulates endocytic trafficking (By similarity). Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A (By similarity). Interacts with SGSM1, SGSM2, SGSM3 and VIPAS39 (By similarity). Interacts with EXOC6 in a GTP-dependent manner. Interacts with RAB11FIP5 (PubMed:11163216). Interacts with STXBP6 (PubMed:12145319). Interacts (GDP-bound form) with ZFYVE27 (PubMed:17082457). Interacts with BIRC6/bruce (By similarity). May interact with TBC1D14 (By similarity). Interacts with UNC119; in a cell cycle-dependent manner (By similarity). GDP-bound and nucleotide-free forms interact with SH3BP5 (By similarity). Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner (By similarity). Interacts (GDP-bound form) with RELCH (By similarity). Found in a complex composed of RELCH, OSBP1 and RAB11A (By similarity). Interacts with TBC1D12 (By similarity). Interacts with DEF6 (By similarity). Interacts with ATP9A (By similarity). Forms a heterotetramer with RAB11FIP3; the GTP-bound form is preferred for binding. Forms a complex with Rabin8/RAB3IP and RAB11FIP3, probably a heterohexamer with two of each protein subunit, where Rabin8/RAB3IP and RAB11FIP3 simultaneously bind to RAB11A; the complex promotes preciliary trafficking and cilia growth. Forms a complex containing RAB11A, ASAP1, Rabin8/RAB3IP, RAP11FIP3 and ARF4; the complex promotes preciliary trafficking; the complex binds to RHO in photoreceptor cells and promotes RHO ciliary transport. Interacts (GTP-bound form) with WDR44; the interaction prevents RAB11A-RAB3IP-RAB11FIP3 complex formation (By similarity).
messages: Recycling endosome membrane
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). The small Rab GTPase RAB11A regulates endocytic recycling (PubMed:11163216). Forms a functional Rab11/FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (By similarity). Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation. On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FI…
messages: phagosome
messages: trans-Golgi network

10116:Rpl34
gene id: 10116:Rpl34
uniprot id: A6HVR8
uniprot id: A6HVR9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

10116:Wrnip1
gene id: 10116:Wrnip1
uniprot id: A6J7J3
uniprot id: Q8CG07
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: Cytoplasm
messages: Forms homooligomers, possibly octamers. Directly interacts with POLD1, POLD2 and POLD4. Interacts with the N-terminal domain of WRN. Interacts (via UBZ4-type zinc finger) with monoubiquitin and polyubiquitin. Interacts with TRIM14 and PPP6C; these interactions positively regulate the RIGI signaling pathway.
messages: Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS.
messages: Nucleus
messages: Sumoylated with SUMO1 and SUMO2/3.
messages: The UBZ4-type zinc finger binds ubiquitin.
messages: Ubiquitously expressed.

10116:Or13a18
gene id: 10116:Or13a18
uniprot id: A0A8I6ABX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Olr1751
gene id: 10116:Olr1751
uniprot id: A6JMS5
uniprot id: M0R722
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Med16
gene id: 10116:Med16
uniprot id: A6K8V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 16 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

10116:Agtpbp1
gene id: 10116:Agtpbp1
uniprot id: A6KAI4
uniprot id: G3V8G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

10116:Khk
gene id: 10116:Khk
uniprot id: Q02974
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.
messages: Homodimer.
messages: Isoform C is most abundant in liver, kidney, gut, spleen and pancreas. Low levels of isoform A found in adrenal, spleen and brain.
messages: Requires potassium. Inhibition by ADP.
messages: The N-terminus is blocked.

10116:Edf1
gene id: 10116:Edf1
uniprot id: P69736
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in cardiomyocytes, cortical and hippocampal neurons.
messages: Expressed in newborn and adult heart and brain tissues. Expression is not evident in prenatal days.
messages: Interacts with TBP and the transcription factor IID (TFIID) complex, NR5A2, NR1H3 and PPARG. Interaction with TBP is regulated by phosphorylation. Binds NR5A1, ATF1 and FOS via their conserved basic region (By similarity). Interacts with JUN. Binding to calmodulin is regulated by calcium and phosphorylation of the IQ motif.
messages: Nucleus
messages: Phosphorylated.
messages: The IQ motif, which is involved in calmodulin binding, overlaps with the binding domain for nuclear receptors and transcription factors. Its phosphorylation probably allows a switch between the two activities of the protein.
messages: Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. Might function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism (By similarity).
messages: Up-regulated upon cardiomyocytes hypertrophy.

10116:Tas2r137
gene id: 10116:Tas2r137
uniprot id: A6IEX7
uniprot id: Q67ET7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
messages: Membrane
messages: Several bitter taste receptors are expressed in a single taste receptor cell.

10116:Atp6v1e2
gene id: 10116:Atp6v1e2
uniprot id: A6H9F3
uniprot id: D3ZJ78
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

10116:Tmub2
gene id: 10116:Tmub2
uniprot id: Q4FZV7
names: Subcellular Location Annotation
messages: Membrane

10116:Atp7a
gene id: 10116:Atp7a
uniprot id: A6IV40
uniprot id: P70705
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (By similarity). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (By similarity). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (By similarity). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (By similarity). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity).
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Contains three di-leucine motifs in the C-terminus which are required for recycling from the plasma membrane to the TGN. The di-leucine 1479-Leu-Leu-1480 motif mediates endocytosis at the plasma membrane, whereas the di-leucine 1459-Leu-Leu-1460 motif is a sorting signal for retrograde trafficking to TGN via early endosomes.
messages: Early endosome membrane
messages: Expressed in hippocampal neuron (at protein level) (PubMed:15634787). Expressed in anterior pituitary gland (at protein level) (PubMed:12488345).
messages: Melanosome membrane
messages: Membrane
messages: Monomer. Interacts with PDZD11. Interacts with ATOX1 and COMMD1 (By similarity). Interacts with TYRP1 (By similarity). Directly interacts with SOD3; this interaction is copper-dependent and is required for SOD3 activity (By similarity).
messages: Postsynaptic density
messages: The heavy-metal-associated domain (HMA) coordinates a Cu(+) ion via the cysteine residues within the CXXC motif. The transfer of Cu(+) ion from ATOX1 to ATP7A involves the formation of a three-coordinate Cu(+)-bridged heterodimer where the metal is shared between the two metal binding sites of ATOX1 and ATP7A. The Cu(+) ion appears to switch between two coordination modes, forming two links with one protein and one with the other. Cisplatin, a chemotherapeutic drug, can bind the CXXC motif and hinder the release of Cu(+) ion.
messages: The nucleotide-binding domain consists of a twisted six-stranded antiparallel beta-sheet flanked by two pairs of alpha-helices, forming an hydrophobic pocket that interacts with the adenine ring of ATP. The ATP binding site comprises residues located in alpha-1 and alpha-2 helices and beta-2 and beta-3 strands, which are involved in van der Waal's interactions, and Glu-1073 which forms an hydrogen bond with the adenine ring.
messages: axon
messages: dendrite
messages: trans-Golgi network membrane

10116:Rnf130
gene id: 10116:Rnf130
uniprot id: Q6Y290
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells.
messages: Cytoplasm
messages: In testis sections, expressed in interstitial tissue and seminiferous tubules. In tubules, expression is mainly in postmeiotic germ cells and to a much lesser extent in Sertoli cells (at protein level). Expressed at high levels in liver, lung, stomach, heart and thymus.
messages: Membrane
messages: Regulated by lutenising hormone (LH) in Leydig cells but not in germ cells.

10116:Ambn
gene id: 10116:Ambn
uniprot id: Q62840
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Ameloblast-specific.
messages: Belongs to the ameloblastin family.
messages: Involved in the mineralization and structural organization of enamel.
messages: extracellular matrix

10116:Immt
gene id: 10116:Immt
uniprot id: A0A0G2JVH4
uniprot id: A0A8I5Y0P8
uniprot id: Q3KR86
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13 (By similarity). This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (By similarity). The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex (By similarity). Interacts with HSPA1A/HSPA1B and OPA1, preferentially with the soluble OPA1 form (By similarity). Interacts with MICOS13/MIC13, MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, SAMM50 and TMEM11 (By similarity). Interacts with APOO/MIC23/MIC26 and APOOL/MIC27 (By similarity). Interacts with ARMC1 (By similarity). Interacts with ARMC12 (By similarity).
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Mitochondrion
messages: Mitochondrion inner membrane

10116:Crem
gene id: 10116:Crem
uniprot id: A0A0G2JYV9
uniprot id: A0A140TAC0
uniprot id: A0A140TAC1
uniprot id: A0A8I5ZW07
uniprot id: A0A8L2QUF6
uniprot id: Q03061
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family.
messages: Binds DNA as a dimer. Interacts with CDC34. Interacts with FHL5. Isoform delta forms a heterodimer with CREB3L4. May interact with TSSK4.
messages: Isoform Tau is expressed in testis germ cells. CREM-theta1- and CREM-theta2-containing isoforms are expressed in testis.
messages: Nucleus
messages: Produced by alternative promoter usage. Activator.
messages: Produced by alternative splicing.
messages: Stimulated by phosphorylation. Phosphorylated on Ser-116 by TSSK4 in vitro.
messages: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform Delta is an activator. Plays a role in spermatogenesis and is involved in spermatid maturation. Binding of isoform Tau (activator) to CRE is increased by CREB3L4. The CREM isoform Tau-CREB3L4 heterodimer functions through CRE and may recruit HIRA to CRE to regulate histone exchange (By similarity).
messages: Ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.

10116:Qdpr
gene id: 10116:Qdpr
uniprot id: P11348
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.
messages: Homodimer.

10116:Glrb
gene id: 10116:Glrb
uniprot id: A6J5T1
uniprot id: P20781
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRB sub-subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Detected in spinal cord and brain stem (at protein level) (PubMed:22592841). Detected in spinal cord, cerebellum and brain cortex (PubMed:2163264).
messages: Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:15574743, PubMed:14551753). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (By similarity).
messages: Heteropentamer composed of GLRB and GLRA1 (PubMed:15574743, PubMed:8581315, PubMed:14551753). Heteropentamer composed of GLRB and GLRA2 (PubMed:8581315). Heteropentamer composed of GLRB and GLRA3 (PubMed:8581315). Heteropentamer composed of two GLRA1 and three GLRB subunits. Heteropentamer composed of three GLRA1 and two GLRB subunits (By similarity). Interacts with GLRA1 (By similarity). Interacts with GPHN (PubMed:8581315, PubMed:15201864, PubMed:16511563).
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite

10116:Tcf7l1
gene id: 10116:Tcf7l1
uniprot id: A0A8I5ZT78
uniprot id: A6IAD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

10116:Ly49si1
gene id: 10116:Ly49si1
uniprot id: Q5MPP4
names: Subcellular Location Annotation
messages: Membrane

10116:Trappc1
gene id: 10116:Trappc1
uniprot id: A6HFP7
uniprot id: Q2KMM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Belongs to the TRAPP small subunits family. BET5 subfamily.
messages: Endoplasmic reticulum
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: Part of the multisubunit transport protein particle (TRAPP) complex. The heterodimer TRAPPC6B-TRAPPC3 interacts with TRAPPC1 likely providing a core for TRAPP complex formation.
messages: cis-Golgi network

10116:Aen
gene id: 10116:Aen
uniprot id: B2GUW6
names: Function
names: Subcellular Location Annotation
messages: Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis (By similarity).
messages: Nucleus
messages: nucleolus

10116:Tcea2
gene id: 10116:Tcea2
uniprot id: Q63799
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TFS-II family.
messages: Interacts with the basal transcription factor GTF2B. Interacts with REXO1 (By similarity).
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus
messages: Testis specific.

10116:Snx7
gene id: 10116:Snx7
uniprot id: Q66H41
names: Similarity
messages: Belongs to the sorting nexin family.

10116:Rgs9bp
gene id: 10116:Rgs9bp
uniprot id: A6JAC0
uniprot id: D3ZC97
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

10116:Pnpla2
gene id: 10116:Pnpla2
uniprot id: P0C548
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Also possesses acylglycerol transacylase and phospholipase A2 activities (By similarity). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (By similarity). Regulates adiposome size and may be involved in the degradation of adiposomes (By similarity). May play an important role in energy homeostasis (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity). Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Increased by rosiglitazone in subcutaneous and visceral white adipose tissue.
messages: Interacts with ABHD5; this association stimulates PNPLA2 triglyceride hydrolase activity (By similarity). Interacts with SERPINF1; this interaction stimulates the phospholipase A2 activity of PNPLA2 (By similarity). Despite a colocalization in lipid droplets, it probably does not interact with PLIN (By similarity). Interacts with PLIN5; prevents interaction with ABHD5 (PubMed:23408028, PubMed:24303154). Interacts with FAF2 (By similarity).
messages: Lipid droplet
messages: Phosphorylation at Ser-398 by PKA is increased during fasting and moderate intensity exercise, and moderately increases lipolytic activity.
messages: Ubiquitinated by PEX2 in response to reactive oxygen species (ROS), leading to its degradation.

10116:Pgm2l1
gene id: 10116:Pgm2l1
uniprot id: A6I6M0
uniprot id: D3Z955
names: Similarity
messages: Belongs to the phosphohexose mutase family.

10116:Pmaip1
gene id: 10116:Pmaip1
uniprot id: Q5U777
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMAIP1 family.
messages: Interacts with MCL1 (By similarity). Interacts with BCL2A1 (By similarity). Interacts with BAX (By similarity). Interacts with BCL2L10 (By similarity).
messages: Mitochondrion
messages: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity).
messages: The BH3 motif is essential for pro-apoptotic activity.

10116:Rpap1
gene id: 10116:Rpap1
uniprot id: Q3T1I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RPAP1 family.
messages: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3 (By similarity).
messages: Nucleus
messages: Part of an RNA polymerase II complex that contains POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, RPAP1, FCP1 plus the general transcription factors TFIIB and TFIIF.

10116:Mtrr
gene id: 10116:Mtrr
uniprot id: Q498R1
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms a multiprotein complex with MMACHC, MMADHC and MTR.
messages: It is debated whether the reduction of free aquacob(II)alamin occurs spontaneously or is enzyme catalyzed.
messages: Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin. Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (By similarity). Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance (By similarity). Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme. Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme (By similarity).

10116:Stat3
gene id: 10116:Stat3
uniprot id: A6HJ64
uniprot id: P52631
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated on lysine residues by CREBBP. Deacetylation by LOXL3 leads to disrupt STAT3 dimerization and inhibit STAT3 transcription activity. Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated.
messages: Activated through tyrosine phosphorylation by BMX. Tyrosine phosphorylated in response to IL6, IL11, CNTF, LIF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha and OSM. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Tyrosine phosphorylated upon stimulation with EGF. Upon LPS challenge, phosphorylated within the nucleus by IRAK1. Phosphorylated on Ser-727 by RPS6KA5 (By similarity). Phosphorylation at Tyr-705 by FER, isoform M2 of PKM (PKM2) or PTK6 leads to an increase of its transcriptional activity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates IL6/interleukin-6 signaling (By similarity).
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Detected in lung, heart, oviduct, ovary, uterus and kidney (at protein level). Detected in ovary, oviduct, and at lower levels in uterus and lung.
messages: Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1. Interacts with IL23R in presence of IL23. Interacts (via SH2 domain) with NLK. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity). Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity). Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation (PubMed:19427337). Interacts with ARL2BP; interaction is enhanced with ARL2. Interacts with NEK6 (By similarity). Binds to CDK9 when activated and nuclear. Interacts with BMX. Interacts with ZIPK/DAPK3. Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. In prostate cancer cells, interacts with PRKCE and promotes DNA binding activity of STAT3 (By similarity). Interacts with STMN3, antagonizing its microtubule-destabilizing activity (By similarity). Interacts with the 'Lys-129' acetylated form of BIRC5/survivin. Interacts with FER. Interacts (via SH2 domain) with EIF2AK2/PKR (via the kinase catalytic domain) (By similarity). Interacts with FGFR4 (By similarity). Interacts with INPP5F; the interaction is independent of STAT3 Tyr-705 phosphorylation status (By similarity). Interacts with OCAD1 (By similarity). Interacts (unphosphorylated or phosphorylated at Ser-727) with PHB1 (By similarity). Interacts and may form heterodimers with NHLH1 (By similarity). Found in a complex with SLC39A6, SLC39A10 and with the 'Ser-727' phosphorylated form of STAT3 throughout mitosis (By similarity).
messages: Involved in the gp130-mediated signaling pathway.
messages: Nucleus
messages: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (By similarity). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (By similarity). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation. May play an apoptotic role by transctivating BIRC5 expression under LEP activation (By similarity). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (By similarity). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
messages: Some lysine residues are oxidized to allysine by LOXL3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity. Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated.

10116:Sgce
gene id: 10116:Sgce
uniprot id: Q6YAT4
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Expressed at embryonic day 20, postnatal days 1, 7, 14, 36, six months and one and a half years. Highest level at 20 dpc. In muscle, expression is over 10 times higher at 20 dpc and during the early postnatal period than in adults. In adults, expression levels are several-fold higher in brain, particularly in the cerebellar cortex, than in muscle.
messages: Golgi apparatus
messages: In both neural tissues including cerebellar cortex, striatum, cerebral cortex, thalamus and hippocampus, and non-neural tissues including quadriceps muscle, liver, kidney, spleen, lung, testis and heart. Widely distributed in the brain, with a robust signal obtained from regions with dense neuronal packing such as the pyramidal cell layer of the hippocampus, cerebellar molecular layer, and cerebral cortex. Levels are highest in kidney, moderate in brain and lung, and low in skeletal muscle, liver, spleen and testis.
messages: N-glycosylated.
messages: Ubiquitinated, leading to its degradation by the proteasome.
messages: cytoskeleton
messages: dendrite
messages: sarcolemma

10116:Gykl1
gene id: 10116:Gykl1
uniprot id: A6IX20
uniprot id: D3Z8F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

10116:Camlg
gene id: 10116:Camlg
uniprot id: Q6DGG9
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the Golgi to ER traffic (GET) complex, which is composed of GET1/WRB, CAMLG/GET2 and GET3/TRC40 (PubMed:23041287). Within the complex, GET1 and CAMLG form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer (By similarity). Interacts (via C-terminus) with GET1 (PubMed:23041287). Interacts (via N-terminus) with GET3 (PubMed:23041287). GET3 shows a higher affinity for CAMLG than for GET1 (By similarity). Interacts (via N-terminus) with TNFRSF13B/TACI (via C-terminus) (By similarity).
messages: Endoplasmic reticulum membrane
messages: In the central nervous system, expressed in astrocytes, microglia and neurons (at protein level).
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287). Required for the stability of GET1 (By similarity). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (By similarity). Essential for the survival of peripheral follicular B cells (By similarity).

10116:Ambp
gene id: 10116:Ambp
uniprot id: A0A8L2Q3T3
uniprot id: A6J7X0
uniprot id: Q64240
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: 3-hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with Cys-53, Lys-111, Lys-137, and Lys-149 to form heterogeneous polycyclic chromophores including hydroxanthommatin. The reaction by alpha-1-microglobulin is autocatalytic; the human protein forms chromophore even when expressed in insect and bacterial cells. The chromophore can react with accessible cysteines forming non-reducible thioether cross-links with other molecules of alpha-1-microglobulin or with other proteins such as Ig alpha-1 chain C region 'Cys-352'.
messages: Antioxidant and tissue repair protein with reductase, heme-binding and radical-scavenging activities. Removes and protects against harmful oxidants and repairs macromolecules in intravascular and extravascular spaces and in intracellular compartments. Intravascularly, plays a regulatory role in red cell homeostasis by preventing heme- and reactive oxygen species-induced cell damage. Binds and degrades free heme to protect fetal and adult red blood cells from hemolysis. Reduces extracellular methemoglobin, a Fe3+ (ferric) form of hemoglobin that cannot bind oxygen, back to the Fe2+ (ferrous) form deoxyhemoglobin, which has oxygen-carrying potential. Upon acute inflammation, inhibits oxidation of low-density lipoprotein particles by MPO and limits vascular damage. Extravascularly, protects from oxidation products formed on extracellular matrix structures and cell membranes. Catalyzes the reduction of carbonyl groups on oxidized collagen fibers and preserves cellular and extracellular matrix ultrastructures. Importantly, counteracts the oxidative damage at blood-placenta interface, preventing leakage of free fetal hemoglobin into the maternal circulation. Intracellularly, has a role in maintaining mitochondrial redox homeostasis. Bound to complex I of the respiratory chain of mitochondria, may scavenge free radicals and preserve mitochondrial ATP synthesis. Protects renal tubule epithelial cells from heme-induced oxidative damage to mitochondria. Reduces cytochrome c from Fe3+ (ferric) to the Fe2+ (ferrous) state through formation of superoxide anion radicals in the presence of ascorbate or NADH/NADPH electron donor cofactors, ascorbate being the preferred cofactor (By similarity). Has a chaperone role in facilitating the correct folding of bikunin in the endoplasmic reticulum compartment (By similarity).
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Expressed by the liver and secreted in plasma.
messages: Heavy chains are interlinked with bikunin via a chondroitin 4-sulfate bridge to the C-terminal aspartate.
messages: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (HC) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of ITIH1/HC1, ITIH2/HC2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of ITIH3/HC3 and bikunin. Interacts with TNFAIP6 (via Link domain).
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Kunitz-type serine protease inhibitor and structural component of extracellular matrix with a role in extracellular space remodeling and cell adhesion. Among others, has antiprotease activity toward kallikrein, a protease involved in airway inflammation; inhibits GZMK/granzyme, a granule-stored serine protease involved in NK and T cell cytotoxic responses; and inhibits PLG/plasmin, a protease required for activation of matrix metalloproteinases. As part of I-alpha-I complex, provides for the heavy chains to be transferred from I-alpha-I complex to hyaluronan in the presence of TNFAIP6, in a dynamic process that releases free bikunin and remodels extracellular matrix proteoglycan structures. Free bikunin, but not its heavy chain-bound form, acts as potent protease inhibitor in airway secretions (By similarity). Part of hyaluronan-rich extracellular matrix that surrounds oocyte during cumulus oophorus expansion, an indispensable process for proper ovulation (By similarity). Also inhibits calcium oxalate crystallization (By similarity).
messages: Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer. Also occurs as a complex with tryptase in mast cells.
messages: Monomer. Homodimer. In plasma, it occurs as a monomer or dimer and in covalently-linked complexes with immunoglobulin A (IgA), ALB/albumin and F2/prothrombin. Chromophore-bound alpha-1-microglobulin interacts with the constant region of immunoglobulin A. Chromophore-bound alpha-1-microglobulin interacts with ALB with molar ratio 2:1 and 1:1; this interaction does not prevent fatty acid binding to ALB. Interacts with F2/prothrombin (via N-terminus) with molar ratio 2:1 and 1:1; this interaction does not prevent the activation of prothrombin to thrombin. Interacts with NDUFAB1, a subunit of mitochondrial complex I (By similarity). Interacts with FN1 (PubMed:7519849).
messages: Nucleus membrane
messages: Proteolytically cleaved by PRSS3 at Kunitz domain 2.
messages: Secreted
messages: The Kunitz domains 1 and 2 serve as protease inhibitor domains.
messages: The precursor is proteolytically processed into separately functioning proteins.
messages: cytosol
messages: extracellular matrix

10116:Cdh23
gene id: 10116:Cdh23
uniprot id: P58365
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cadherin repeats 1 and 2 mediate calcium-dependent heterophilic interaction with PCDH15.
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
messages: Cell membrane
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
messages: antiparallel heterodimer with PCDH15 (By similarity). Interacts with USH1C and USH1G (By similarity).

10116:Cpox
gene id: 10116:Cpox
uniprot id: Q3B7D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity).
messages: Mitochondrion intermembrane space

10116:Dusp15
gene id: 10116:Dusp15
uniprot id: B4F7B7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Cell membrane
messages: Expression increases during oligodendrocyte differentiation.
messages: May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation (PubMed:27532821). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (PubMed:27891578). May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (By similarity).

10116:Creb3l4
gene id: 10116:Creb3l4
uniprot id: Q5UEM7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Binds DNA as a dimer. Forms a heterodimer with CREM isoform Delta (By similarity).
messages: Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).
messages: Endoplasmic reticulum membrane
messages: Nucleus
messages: Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements. Increases the binding of CREM isoform Delta with CRE. The CREM isoform Delta-CREB3L4 heterodimer functions through CRE but not through UPRE and may recruit HIRA to CRE to regulate histone exchange (By similarity).

10116:Nnat
gene id: 10116:Nnat
uniprot id: A0A8L2QVS0
uniprot id: Q62649
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Appears in the mid embryonic period and becomes abundant at 16 dpc to 19 dpc. Postnatally its expression decline and only minimal levels were present in adulthood.
messages: Belongs to the neuronatin family.
messages: Brain.
messages: May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system.

10116:Slc48a1
gene id: 10116:Slc48a1
uniprot id: B0BNL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRG family.
messages: Endosome membrane
messages: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment. In macrophages of the reticuloendothelial system, is the heme transporter for heme-iron recycling. Essential for macrophage iron homeostasis, transports heme from the phagolysosome to the cytoplasm during erythrophagocytosis (EP).
messages: Lysosome membrane
messages: phagosome membrane

10116:Ccnf
gene id: 10116:Ccnf
uniprot id: A6HCR2
uniprot id: Q8K4F8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family.
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF (By similarity). Interacts with SKP1 (By similarity). Interacts with CUL1 (By similarity). Interacts with CCNB1; interaction is required for nuclear localization of CCNB1 (By similarity). Interacts with CCP110; this interaction leads to CCP110 ubiquitination and degradation via the proteasome pathway (By similarity). Interacts (via the Cyclin N-terminal domain) with MYBL2/BMYB (By similarity). Interacts with FZR1/CDH1 (via N-terminus) (By similarity). Interacts with RRM2 (via Cy motif and when phosphorylated at 'Thr-33'); the interaction occurs exclusively in G2 and early M (By similarity). Interacts with CDC6 (via Cy motif); the interaction takes place during G2 and M phase (By similarity).
messages: Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation is not dependent on the proteasome or ubiquitin and depends on the C-terminal PEST sequence.
messages: Nucleus
messages: Phosphorylated just before cells enter into mitosis.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (By similarity). Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability (By similarity). Mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication (By similarity). In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability (By similarity). Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry (By similarity). May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB (By similarity).
messages: The D box motifs 1-4 (amino acid sequence RxxL) are involved in substrate binding, such as FZR1/CDH1, and may be ubiquitinated.
messages: The nuclear localization signals mediate the localization to the nucleus and are required for CCNB1 localization to the nucleus.
messages: Ubiquitinated by the anaphase-promoting complex (APC/C); leading to its degradation by the proteasome.
messages: centriole
messages: perinuclear region

10116:Mitd1
gene id: 10116:Mitd1
uniprot id: Q5I0J5
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Interacts (via MIT domain) with CHMP1A, CHMP1B, CHMP2A and IST1 (By similarity).
messages: Late endosome membrane
messages: Membrane
messages: Midbody
messages: Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT complexes. Seems not to be involved in endosomal transport (By similarity).
messages: The C-terminal domain interacts with lipid membranes containing acidic phosphoinositides and is required for location at the midbody.
messages: The MIT domain interacts with the MIT-interacting motifs of several components of the ESCRT-III complex.

10116:Hmox1
gene id: 10116:Hmox1
uniprot id: A6JY98
uniprot id: P06762
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A soluble form arises by proteolytic removal of the membrane anchor.
messages: Belongs to the heme oxygenase family.
messages: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:3865203, PubMed:1935972, PubMed:1575508). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (By similarity).
messages: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.
messages: Endoplasmic reticulum membrane
messages: Homodimer and higher order homooligomer. Oligomerization is crucial for its stability and function in the endoplasmic reticulum. Interacts with FLVCR2; this interaction is potentiated in the presence of heme.
messages: Induced by its substrate heme and CoCl2.
messages: Inhibited by metalloporphyrins such as Sn- and Zn-protoporphyrins.
messages: The transmembrane domain is necessary for its oligomerization.

10116:Itgad
gene id: 10116:Itgad
uniprot id: Q9QYE7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the integrin alpha chain family.
messages: Heterodimer of an alpha and a beta subunit. Alpha-D associates with beta-2 (By similarity).
messages: Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood (By similarity).
messages: Membrane
messages: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

10116:Lactb
gene id: 10116:Lactb
uniprot id: A0A8I5ZR42
uniprot id: A6KEZ7
uniprot id: D3ZFJ6
names: Subcellular Location Annotation
messages: Mitochondrion

10116:Nup50
gene id: 10116:Nup50
uniprot id: O08587
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with regulatory proteins of cell cycle progression including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B.
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.
messages: Does not interact with TPR (By similarity). Interacts with Importin alpha-2, Importin beta, Importin beta-2, NUP153, Ran binding protein 7, CDKN1B and itself.
messages: Highly expressed in testis, intermediate levels in kidney, liver, spleen and low basal levels in somatic cells. Expression in testis undergoes changes and subcellular localization during germ cell differentiation.
messages: Nucleus membrane
messages: nuclear pore complex

10116:Ugt1a2
gene id: 10116:Ugt1a2
uniprot id: F7EP24
uniprot id: Q6T5F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

10116:Tnfsf8
gene id: 10116:Tnfsf8
uniprot id: A6J7Z4
uniprot id: M0R3V3
names: Similarity
messages: Belongs to the tumor necrosis factor family.

10116:Cpne3
gene id: 10116:Cpne3
uniprot id: A6IIC6
uniprot id: D3ZLA3
names: Similarity
messages: Belongs to the copine family.

10116:Lipa
gene id: 10116:Lipa
uniprot id: A0A0G2K7Y6
uniprot id: Q6IMY6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

10116:Tex28
gene id: 10116:Tex28
uniprot id: F1LWH7
names: Similarity
messages: Belongs to the TEX28 family.

10116:Vps4b
gene id: 10116:Vps4b
uniprot id: Q4KLL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

10116:Bpifa2
gene id: 10116:Bpifa2
uniprot id: Q63471
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
messages: Detected in neonatal submandibular and parotid gland secretion but not in sublingual gland secretion (at protein level). In submandibular gland, expressed at high levels in the first postnatal week, with expression diminishing thereafter.
messages: Expressed in parotid, submandibular and sublingual glands.
messages: Has strong antibacterial activity against P. aeruginosa.
messages: Secreted

10116:Anp32b
gene id: 10116:Anp32b
uniprot id: Q9EST6
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ANP32 family.
messages: Directly cleaved by caspase-3/CASP3.
messages: Expressed specifically during the late G1 and S phases.
messages: Histone binding is mediated by the concave surface of the LRR region.
messages: Interacts with histones H3 and H4. Interacts with KLF5; this interaction induces promoter region-specific histone incorporation and inhibition of histone acetylation by ANP32B.
messages: Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription. Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle (PubMed:11162633). As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:16499868). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes. Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (By similarity). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity).
messages: Nucleus
messages: Predominantly expressed in brain. Expressed in the entire embryonic brain, whereas in the adult brain its expression is restricted to the subventricular zone where there are neural progenitor cells.
messages: Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).
messages: Suppression of the expression of this gene by RNAi induces apoptosis.

10116:Fahd2a
gene id: 10116:Fahd2a
uniprot id: B2RYW9
names: Function
names: Similarity
messages: Belongs to the FAH family.
messages: May have hydrolase activity.

10116:Dnase1l3
gene id: 10116:Dnase1l3
uniprot id: A6K0C3
uniprot id: O89107
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DNase I family.
messages: Detected at high levels in spleen, lymph nodes, thymus and liver. Observed also in kidney and testis, but not in brain or heart.
messages: Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (PubMed:7957253). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (By similarity). Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).
messages: Inhibited by zinc.
messages: Monomer.
messages: Nucleus
messages: Poly-ADP-ribosylated by PARP1. ADP-ribosylation negatively regulates enzymatic activity during apoptosis.
messages: Secreted
messages: Seems to be synthesized as an inactive precursor protein and converted into an active mature enzyme by removal of the N-terminal precursor peptide during apoptosis.

10116:LOC686288
gene id: 10116:LOC686288
uniprot id: A1A5L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Lrp4
gene id: 10116:Lrp4
uniprot id: Q76LU2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Mag
gene id: 10116:Mag
uniprot id: P07722
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (PubMed:8995428, PubMed:9298990). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides (PubMed:17640868). In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides (PubMed:17640868). In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides (PubMed:19367338). Inhibits axon longitudinal growth (PubMed:9298990). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid (PubMed:8995428). Binds ganglioside Gt1b (PubMed:8995428).
messages: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
messages: Cell membrane
messages: Detected in myelin (PubMed:17640868). Detected in olfactory bulb and throughout the brain (at protein level) (PubMed:4020419). Detected in brain (PubMed:2432614).
messages: Membrane raft
messages: Monomer and homodimer (By similarity). Interacts (via the first three N-terminal Ig-like domains) with RTN4R and RTN4RL2 (PubMed:19420245). Interacts with isoform 2 of BSG (By similarity).
messages: N-glycosylated.
messages: Phosphorylated on tyrosine residues.
messages: The C-terminal cytoplasmic region found only in isoform L-MAG is required for normal myelination in the central nervous system (CNS), but is apparently not required for normal myelination in the peripheral nervous system (PNS).
messages: The extracellular domain is required to protect against axon degeneration (By similarity). The first three Ig-like domains mediate interaction with RTN4R and RTN4RL2, but are not sufficient to inhibit neurite outgrowth (PubMed:19420245). The two C-terminal extracellular Ig-like C2-type domains are required for inhibition of axon longitudinal growth (PubMed:9298990, PubMed:19420245, PubMed:19367338). Besides, the two C-terminal extracellular Ig-like C2-type domains are required for protection against apoptosis after nerve injury (By similarity).
messages: Ubiquitinated, leading to proteasomal degradation.

10116:Pigc
gene id: 10116:Pigc
uniprot id: A6ID87
uniprot id: Q5PQQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIGC family.
messages: Component of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex composed at least by PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2. Interacts with PIGQ. Interacts with the heterodimer PIGA:PIGH.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.

10116:Minar2
gene id: 10116:Minar2
uniprot id: A6IX95
uniprot id: B2GUX6
uniprot id: F7EQ04
names: Similarity
messages: Belongs to the MINAR family.

10116:Cyp4a2
gene id: 10116:Cyp4a2
uniprot id: P20816
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase that catalyzes omega and omega-1 hydroxylation of saturated fatty acids. Exhibits preferential omega versus omega-1 regioselectivity and (R) versus (S) stereoselectivity for hydroxylation of lauric and myristic acids (PubMed:10869363, PubMed:10620324). Has low activity toward palmitic acid (PubMed:10620324). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10869363, PubMed:10620324).
messages: Belongs to the cytochrome P450 family.
messages: By clofibrate.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

10116:Sntb1
gene id: 10116:Sntb1
uniprot id: A6HRH8
uniprot id: D3ZWC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

10116:Clca4
gene id: 10116:Clca4
uniprot id: Q6VPP3
names: Similarity
messages: Belongs to the CLCR family.

10116:Cacng7
gene id: 10116:Cacng7
uniprot id: A6KS40
uniprot id: P62957
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Cell membrane
messages: Expressed in brain, heart, lung and testis.
messages: Interacts with CACNA1C. Identified in a complex with the L-type calcium channel subunits CACNA1C, CACNA2D1 and either CACNB1 or CACNB2 (By similarity). Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs), such as GRIA1 and GRIA2 (PubMed:19234459, PubMed:19265014).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:18817736, PubMed:19234459). Shows specificity only for GRIA1 and GRIA2 (By similarity).
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2.

10116:Chml
gene id: 10116:Chml
uniprot id: A0A8I6AAJ7
uniprot id: A6JGB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

10116:Nradd
gene id: 10116:Nradd
uniprot id: Q8K5A9
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Detected in embryo, including embryonic brain. Detected at very low levels in adult testis, spleen, thymus and lung.
messages: Highly expressed in embryo. Expressed at very low levels in adult.
messages: Interacts with NTRK1 (By similarity). Isoform 1 and isoform 2 interact with NGFR. Interacts with SORT1.
messages: Isoform 1 is N-glycosylated. Isoform 2 is not N-glycosylated.
messages: Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR (By similarity). Both isoform 1 and isoform 2 promote apoptosis.
messages: Nucleus

10116:Taok1
gene id: 10116:Taok1
uniprot id: O88664
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated (By similarity). Phosphorylated by ATM in response to DNA damage. Phosphorylated by LRRK2 (By similarity).
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Proteolytically processed by caspase-3 (CASP3).
messages: Self-associates. Interacts with MAP2K3. Interacts with SPRED1 (PubMed:18216281). Interacts with TESK1; the interaction inhibits TAOK1 kinase activity (PubMed:18216281). Interacts with MAP3K7 (By similarity).
messages: Serine/threonine-protein kinase activity is inhibited by SPRED1.
messages: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. During fetal development, it plays an essential role in the regulation of neuronal differentiation and migration to the cortical plate (By similarity).

10116:Rab12
gene id: 10116:Rab12
uniprot id: P35284
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Golgi apparatus membrane
messages: Highest levels in skeletal and cardiac muscle. Also found in comparable amounts in brain, spinal cord and lung. Also detected in testis where it is expressed by Sertoli cells of the seminiferous tubules (at protein level).
messages: Interacts with RABIF and OPTN (By similarity). Interacts with LRRK2; interaction facilitates phosphorylation of Ser-105 (By similarity). Interacts with GDI1, GDI2 and CHM; these interactions are disrupted by phosphorylation on Ser-105 (By similarity). Interacts with RILPL1 and RILPL2; these interactions are dependent on phosphorylation of Ser-105 (By similarity).
messages: Lysosome membrane
messages: Phosphorylation of Ser-105 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM and RAB GDP dissociation inhibitors GDI1 and GDI2.
messages: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). That Rab is activated by DENND3, a guanine exchange factor (By similarity).
messages: Recycling endosome membrane
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity).
messages: autophagosome

10116:Alb
gene id: 10116:Alb
uniprot id: A0A0G2JSH5
uniprot id: P02770
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A peptide arising from positions 166 to 174 was originally termed neurotensin-related peptide (NRP) and was thought to regulate fat digestion, lipid absorption, and blood flow.
messages: Belongs to the ALB/AFP/VDB family.
messages: Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).
messages: Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity). Interacts with TASOR (By similarity). In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin; this interaction does not prevent fatty acid binding to ALB.
messages: Phosphorylated by FAM20C in the extracellular medium.
messages: Plasma.
messages: Secreted

10116:Oas1h
gene id: 10116:Oas1h
uniprot id: Q5MYW7
names: Similarity
messages: Belongs to the 2-5A synthase family.

10116:Rara
gene id: 10116:Rara
uniprot id: A0A0G2JW78
uniprot id: A6HIV8
uniprot id: A6HIV9
uniprot id: F7EXR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

10116:Alkbh5
gene id: 10116:Alkbh5
uniprot id: D3ZKD3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkB family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity).
messages: Monomer.
messages: Nucleus speckle

10116:Hhex
gene id: 10116:Hhex
uniprot id: A0A9K3Y8F2
uniprot id: Q9WV22
names: Subcellular Location Annotation
messages: Nucleus

10116:Or1e1c
gene id: 10116:Or1e1c
uniprot id: A0A8I5XVL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Cuzd1
gene id: 10116:Cuzd1
uniprot id: Q9QZT0
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By estrogen, tamoxifen and growth hormone. Repressed by progesterone and by the antiestrogen ICI 182780.
messages: Expressed predominantly in epithelium of uterus and oviduct.
messages: In uterus, strongly expressed at proestrus, declines at estrus and disappears at diestrus. In oviduct, strongly expressed at both proestrus and estrus but declines significantly at diestrus. In uterus, highly expressed on day 1 of pregnancy but declines dramatically on day 2 and is not detected between days 3 and 7. In oviduct, highly expressed on days 1 and 2 of pregnancy but declines significantly on days 3 and 4.
messages: Localized to zymogen granules, where it functions in trypsinogen activation (By similarity). May indirectly regulate cell motility, cell-cell and cell/extracellular matrix interactions (By similarity).
messages: Zymogen granule membrane

10116:Ndufa2
gene id: 10116:Ndufa2
uniprot id: A6J329
uniprot id: D3ZS58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

10116:Lhfpl4
gene id: 10116:Lhfpl4
uniprot id: A6IBP5
uniprot id: Q7TSY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LHFP family.
messages: Interacts with GABA(A) receptor subunits (PubMed:28279354). Interacts with GABRB3 (By similarity). Interacts with GABRA2 (By similarity). Interacts with GABRG2 (By similarity). Interacts with GABRA1 (PubMed:28279354). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (PubMed:28279354). Interacts with NLGN2; leading to mutual regulation of protein level and synaptic clustering (By similarity).
messages: Membrane
messages: Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma-aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs.
messages: Postsynaptic cell membrane
messages: dendrite

10116:Ngly1
gene id: 10116:Ngly1
uniprot id: Q5XI55
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Binds 1 zinc ion per subunit.
messages: Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Interacts with the proteasome components RAD23B and PSMC1. Interacts with directly with VCP. Interacts with DERL1, bringing it close to the endoplasmic reticulum membrane. Interacts with SAKS1 (By similarity).
messages: Cytoplasm
messages: Inhibited by Z-VAD-fmk, a well-known caspase inhibitor, which inhibits enzyme activity through covalent binding of the carbohydrate to the single Cys-306 residue.
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity).
messages: The PUB domain mediates the interaction with VCP.

10116:Fn1
gene id: 10116:Fn1
uniprot id: A0A096P6L8
uniprot id: A0A8I6A5M1
uniprot id: A6KFG4
uniprot id: A6KFG5
uniprot id: A6KFG6
uniprot id: A6KFG8
uniprot id: F1LST1
names: Function
messages: Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling.

10116:Mettl7b
gene id: 10116:Mettl7b
uniprot id: Q562C4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the methyltransferase superfamily.
messages: Endoplasmic reticulum membrane
messages: Highly expressed in liver and kidney. No expression in testis, heart, lung, brain, spleen or cultured fibroblasts.
messages: Lipid droplet
messages: Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-l-methionine to hydrogen sulfide and other thiol compounds including dithiothreitol, 7alpha-thiospironolactone, L-penicillamine, and captopril.

10116:Ncbp3
gene id: 10116:Ncbp3
uniprot id: A6HGH8
uniprot id: D3ZXL5
names: Similarity
messages: Belongs to the NCBP3 family.

10116:Aadacl2fm3
gene id: 10116:Aadacl2fm3
uniprot id: A6JVL0
uniprot id: F1LVG7
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

10116:Uvssa
gene id: 10116:Uvssa
uniprot id: A0A096P6L4
uniprot id: D3ZND0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UVSSA family.
messages: Chromosome
messages: Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Also facilitates transfer of TFIIH to RNA polymerase II. Not involved in processing oxidative damage.
messages: Interacts with the elongating form of RNA polymerase II (RNA pol IIo) during transcription stress. Interacts with the TFIIH complex during transcription stress. Interacts with ERCC6. Interacts with ERCC8. Interacts with USP7.
messages: Monoubiquitinated at Lys-419 in response to transcription stress; this promotes efficient transfer of TFIIH to stalled RNA polymerase II.

10116:Itgb7
gene id: 10116:Itgb7
uniprot id: A6KCT9
uniprot id: G3V7M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

10116:Or52n3
gene id: 10116:Or52n3
uniprot id: A6I7G4
uniprot id: D3ZB08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Hbz
gene id: 10116:Hbz
uniprot id: A6HDA9
uniprot id: G3V8R3
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.

10116:Aurkb
gene id: 10116:Aurkb
uniprot id: A6HFM8
uniprot id: O55099
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated at Lys-218 by KAT5 at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis.
messages: Activity is greatly increased when AURKB is within the CPC complex. In particular, AURKB-phosphorylated INCENP acts as an activator of AURKB. Positive feedback between HASPIN and AURKB contributes to CPC localization.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: Chromosome
messages: Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist. Associates with RACGAP1 during M phase. Interacts with CDCA1, EVI5, JTB, NDC80, PSMA3, SEPTIN1, SIRT2 and TACC1. Interacts with SPDYC; this interaction may be required for proper localization of active, Thr-235-phosphorylated AURKB form during prometaphase and metaphase. Interacts with p53/TP53. Interacts (via the middle kinase domain) with NOC2L (via the N- and C-terminus domains). Interacts with TTC28 (By similarity). Interacts with RNF2/RING1B (By similarity).
messages: High level expression seen in the testis. It is also expressed in the spleen, lung and heart. Expressed in the G2/M phase of the cell cycle.
messages: Midbody
messages: Nucleus
messages: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (By similarity). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:9450992). Required for central/midzone spindle assembly and cleavage furrow formation (By similarity). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (By similarity). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (By similarity). Phosphorylation of INCENP leads to increased AURKB activity (By similarity). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (By similarity). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (By similarity). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (By similarity). AURKB is also required for kinetochore localization of BUB1 and SGO1 (By similarity). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (By similarity). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of…
messages: The phosphorylation of Thr-235 requires the binding to INCENP and occurs by means of an autophosphorylation mechanism. Thr-235 phosphorylation is indispensable for the AURKB kinase activity.
messages: Ubiquitinated by different BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complexes. Ubiquitinated by the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, ubiquitination leads to removal from mitotic chromosomes and is required for cytokinesis. During anaphase, the BCR(KLHL21) E3 ubiquitin ligase complex recruits the CPC complex from chromosomes to the spindle midzone and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome. Deubiquitinated by USP35; inhibiting CDH1-mediated degradation of AURKB.
messages: centromere
messages: kinetochore
messages: spindle

10116:Rorc
gene id: 10116:Rorc
uniprot id: A0A8I6GEH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

10116:Pnpo
gene id: 10116:Pnpo
uniprot id: A6HIH6
uniprot id: O88794
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Detected at low levels in fetal brain, and at high levels in adult brain.
messages: Detected in adult liver.
messages: Homodimer.

10116:Pkn2
gene id: 10116:Pkn2
uniprot id: F1LPA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

10116:Pcsk1n
gene id: 10116:Pcsk1n
uniprot id: Q9QXU9
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding.
messages: Expressed by 12.5 dpc in essentially all differentiating neurons in the mantle layer of the myelencephalon, metencephalon, diencephalon, spinal cord and several sympathetic ganglia. During later stages of prenatal development, widespread expression continues in post-mitotic neurons of both the CNS and PNS and begins in endocrine cells of the anterior and intermediate pituitary.
messages: Expressed in adult brain (all major structural regions), adrenal gland (medulla) and spinal cord (dorsal and ventral horn). Expressed in pancreatic islands.
messages: Interacts via the C-terminal inhibitory domain with PCSK1 65 kDa form.
messages: May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1 (PubMed:10632593, PubMed:10816562). ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 65 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity).
messages: ProSAAS(1-180) increases secretion of enzymatically inactive PCSK1.
messages: Proteolytically cleaved in the Golgi. Big SAAS, Little SAAS, PEN and Big LEN are the major processed peptides in proSAAS-overexpressing PC-12 phaeochromocytoma cells (lacking PCSK1 and PCSK2 endopeptidases). Peptides corresponding to PEN and a proSAAS aa 40-59 have been detected in wild-type PC-12 cells.
messages: Secreted
messages: The C-terminal inhibitory domain is involved in inhibition of PCSK1. It corresponds to the probable processing intermediate Big PEN-LEN, binds to PCSK1 in vitro and contains the hexapeptide L-L-R-V-K-R, which, as a synthetic peptide, is sufficient for PCSK1 inhibition.
messages: The four C-terminal amino acids of Big LEN are sufficient to bind and activate GPR171.
messages: trans-Golgi network

10116:Snx16
gene id: 10116:Snx16
uniprot id: P57769
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sorting nexin family.
messages: Cytoplasm
messages: Early endosome membrane
messages: Homooligomer. Interacts with EGFR.
messages: Late endosome membrane
messages: Lysosome
messages: May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling.
messages: The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.

10116:Tbxt
gene id: 10116:Tbxt
uniprot id: A6KK19
uniprot id: D4A4W8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

10116:Nde1
gene id: 10116:Nde1
uniprot id: A6KU37
uniprot id: Q9ES39
names: Function
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nudE family.
messages: Cleavage furrow
messages: Expressed in brain, heart, kidney, liver, lung, skeletal muscle, spleen and testis.
messages: Intron retention.
messages: Phosphorylated in mitosis.
messages: Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex (By similarity).
messages: Self-associates. May interact with CENPF, CNTRL, LIS1, dynactin, dynein, tubulin gamma, PCM1, PCNT, SLMAP and TCP1 (By similarity). Interacts with PAFAH1B1. Interacts with ZNF365 (By similarity).
messages: centrosome
messages: cytoskeleton
messages: kinetochore
messages: spindle

10116:Egr4
gene id: 10116:Egr4
uniprot id: Q00911
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: By nerve growth factor.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.

10116:Pfkfb3
gene id: 10116:Pfkfb3
uniprot id: A6JLS4
uniprot id: A6JLS5
uniprot id: A6JLS7
uniprot id: A6JLS8
uniprot id: A6JLS9
uniprot id: A6JLT0
uniprot id: O35552
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Catalyzes both the synthesis and degradation of fructose 2,6-bisphosphate.
messages: Homodimer. Forms a heterodimer with PFKFB2 (By similarity).
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.
messages: Phosphorylation by AMPK stimulates activity.

10116:Cpne2
gene id: 10116:Cpne2
uniprot id: F1M1L9
names: Similarity
messages: Belongs to the copine family.

10116:Ext1
gene id: 10116:Ext1
uniprot id: A6HRF2
uniprot id: G3V901
uniprot id: Q3B8R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

10116:Unc93b1
gene id: 10116:Unc93b1
uniprot id: A0A8I5ZSD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

10116:Ranbp6
gene id: 10116:Ranbp6
uniprot id: A6I0X4
uniprot id: D4A634
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

10116:Vdac1
gene id: 10116:Vdac1
uniprot id: A6HEA9
uniprot id: Q9Z2L0
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Cell membrane
messages: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.
messages: Forms a channel through the mitochondrial outer membrane and also the plasma membrane (By similarity). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (By similarity). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:25628567). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (By similarity). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (By similarity). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (By similarity). May mediate ATP export from cells (By similarity).
messages: Homodimer and homotrimer; in response to cyclic AMP or calcium. Interacts with hexokinases including HK1. The HK1-VDAC1 complex interacts with ATF2. Interacts with BCL2L1. Interacts with BAK1. Interacts with RTL10/BOP (via BH3 domain). Interacts with amyloid-beta and APP; induces VDAC1 dephosphorylation. Component of the mitochondrial permeability transition pore complex (mPTPC), at least composed of SPG7, VDAC1 and PPIF. Interacts with SPG7, NIPSNAP2 and SLC25A30. Interacts with TMEM41B. Interacts with BCAP31.
messages: Inhibited by nitric oxide.
messages: Membrane raft
messages: Mitochondrion outer membrane
messages: Phosphorylation at Ser-193 by NEK1 promotes the open conformational state preventing excessive mitochondrial membrane permeability and subsequent apoptotic cell death after injury. Phosphorylation by the AKT-GSK3B axis stabilizes the protein probably by preventing ubiquitin-mediated proteasomal degradation.
messages: Ubiquitinated. Undergoes monoubiquitination and polyubiquitination by PRKN; monoubiquitination at Lys-274 inhibits apoptosis, whereas polyubiquitination leads to its degradation and promotes mitophagy. Deubiquitinated by USP30.
messages: Widely expressed. High levels in heart and kidney with lower levels in brain and ascitic tumor. Very low levels in liver.

10116:Hist1h2ah
gene id: 10116:Hist1h2ah
uniprot id: K7R8M0
uniprot id: P0C170
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
messages: Deiminated on Arg-4 in granulocytes upon calcium entry.
messages: Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
messages: Nucleus
messages: Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
messages: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Up-regulated in hepatocytes after treatment with the procarcinogen N-nitrosodiethylamine (NDEA).

10116:Olr1240
gene id: 10116:Olr1240
uniprot id: D3ZU37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Sdhb
gene id: 10116:Sdhb
uniprot id: P21913
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD (By similarity). Interacts with SDHAF1; the interaction is required for iron-sulfur cluster incorporation into SDHB (By similarity).
messages: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

10116:Ube2k
gene id: 10116:Ube2k
uniprot id: A6JDD4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

10116:Syt14
gene id: 10116:Syt14
uniprot id: A0A8I6ALQ7
uniprot id: A0A8I6AMJ4
names: Similarity
messages: Belongs to the synaptotagmin family.

10116:Exosc9
gene id: 10116:Exosc9
uniprot id: A6IHY2
uniprot id: Q4QR75
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family.
messages: Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts (via C-terminus region) with SETX (via N-terminus domain); the interaction enhances SETX sumoylation (By similarity).
messages: Cytoplasm
messages: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs (By similarity).
messages: Nucleus
messages: The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active.
messages: nucleolus
messages: nucleoplasm

10116:Brcc3
gene id: 10116:Brcc3
uniprot id: B2RYM5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. BRCC36 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin (By similarity). Interacts with PWWP2B (By similarity). Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B (By similarity).
messages: Cytoplasm
messages: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (By similarity). Acts as a regulator of the NLRP3 inflammasome by mediating deubiquitination of NLRP3, leading to NLRP3 inflammasome assembly (By similarity). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (By similarity). Deubiquitinates HDAC1 and PWWP2B leading to their stabilization (By similarity).
messages: Nucleus
messages: spindle pole

10116:Prkg2
gene id: 10116:Prkg2
uniprot id: Q64595
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
messages: Binding of cGMP results in enzyme activation.
messages: Cell membrane
messages: Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane (PubMed:9465038). Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (Probable). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (PubMed:18031684). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).
messages: Highly expressed in intestinal mucosa and is 20 times less abundant in brain and kidney (PubMed:7937783). Expressed in jejunum, in the apical domain of the villus epithelium (PubMed:15872007).
messages: Interacts with GRIA1/GLUR1.
messages: Myristoylation mediates membrane localization.

10116:Gucy2f
gene id: 10116:Gucy2f
uniprot id: A6KG67
uniprot id: P51842
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by GUCA1B when free calcium ions concentration is low, and inhibited by GUCA1B when free calcium ions concentration is high (By similarity). Inhibited by RD3 (By similarity).
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Expressed only in the eye.
messages: Homodimer (PubMed:9153227). Interacts with RD3; promotes the exit of GUCY2F from the endoplasmic reticulum and its trafficking to the photoreceptor outer segments (By similarity).
messages: Membrane
messages: Photoreceptor outer segment membrane
messages: Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:7831337). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity).
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.

10116:Kcnk4
gene id: 10116:Kcnk4
uniprot id: G3V8V5
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by arachidonic acid.
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Channel opening is brought about by a conformation change that involves buckling of the second transmembrane helix and affects the position and orientation of the fourth transmembrane helix.
messages: Detected in brain, and at much lower levels in liver, skeletal muscle and testis.
messages: Homodimer; disulfide-linked.
messages: Voltage-insensitive potassium channel (PubMed:11374070, PubMed:15677687). Channel opening is triggered by mechanical forces that deform the membrane, and by raising the intracellular pH to basic levels (PubMed:11374070, PubMed:15677687). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (PubMed:15677687). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity).

10116:Tbr1
gene id: 10116:Tbr1
uniprot id: D4A6N8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

10116:Phyh
gene id: 10116:Phyh
uniprot id: P57093
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhyH family.
messages: Catalyzes the 2-hydroxylation of racemic phytanoyl-CoA and the isomers of 3-methylhexadecanoyl-CoA (PubMed:10588950, PubMed:10744784). Shows activity also towards a variety of other mono-branched 3-methylacyl-CoA esters (with a chain length of at least seven carbon atoms) and straight-chain acyl-CoA esters (with a chain length longer than four carbon atoms) (By similarity). Does not hydroxylate long and very long straight chain acyl-CoAs or 2-methyl-and 4-methyl-branched acyl-CoAs (By similarity).
messages: Interacts specifically with FKBP52 and PHYHIP.
messages: Peroxisome

10116:Glyatl2
gene id: 10116:Glyatl2
uniprot id: A6I0E6
uniprot id: Q9Z2Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acyltransferase which transfers the acyl group to the N-terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines (By similarity).
messages: Belongs to the glycine N-acyltransferase family.
messages: Binds to microtubules.
messages: Specifically expressed in kidney and liver. Up-regulated in the regenerating liver as well as in hepatocellular carcinoma.
messages: centrosome

10116:Taok3
gene id: 10116:Taok3
uniprot id: Q53UA7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade. Phosphorylated by LRRK2 (By similarity).
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Self-associates. Interacts with ERN1 and TRAF2. Interaction with TRAF2 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation (By similarity).
messages: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity).
messages: Ubiquitously expressed, with a higher expression in the retina.

10116:Frs3
gene id: 10116:Frs3
uniprot id: Q52RG8
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2 (By similarity).
messages: Binds NTRK1, FGFR1, NGFR, GRB2, PTPN11 and ERK2.
messages: Membrane
messages: Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB.

10116:Tmc8
gene id: 10116:Tmc8
uniprot id: B1H258
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

10116:Il22
gene id: 10116:Il22
uniprot id: A6IGU9
uniprot id: G3V6X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Secreted

10116:Stk39
gene id: 10116:Stk39
uniprot id: A0A0G2K007
uniprot id: O88506
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated following phosphorylation at Thr-240 by WNK kinases (WNK1, WNK2, WNK3 or WNK4).
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:22544747). Specifically recognizes and binds proteins with a RFXV motif (By similarity). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:22544747). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (By similarity). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:22544747). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (By similarity). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities. Phosphorylates RELT (By similarity).
messages: Expressed in the early gut and pancreatic epithelium, at 15 dpc day localized to cells that will eventually become exocrine. Expressed in choroid plexus, developing myocardium, pancreatic epithelium and dorsal root ganglia.
messages: Highly expressed in testis followed by pancreas, kidney, heart and brain (PubMed:9675032, PubMed:10990492). Not expressed in skeletal muscle, liver, lung and spleen (PubMed:9675032, PubMed:10990492).
messages: Nucleus
messages: PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by facilitating interaction with intracellular proteins such as actin or actin-like proteins.
messages: Phosphorylation at Thr-240 by WNK kinases (WNK1, WNK2, WNK3 or WNK4) is required for activation (PubMed:16083423, PubMed:16263722). Autophosphorylation at Thr-240 positively regulates its activity (By similarity). Phosphorylated at Ser-318 by PRKCQ (By similarity).
messages: The phosphorylated form forms a complex with WNK2 (By similarity). Interacts with RELT (By similarity). Interacts with SORL1 (via cytosolic C-terminus) (By similarity).

10116:Cdk4
gene id: 10116:Cdk4
uniprot id: A6HQS0
uniprot id: P35426
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Both phosphorylation at Thr-172 and binding of a D-type cyclin are necessary for enzymatic activity. Full activation of the cyclin-D-CDK4 complex appears to require other factors such as recruitment of the substrate via a substrate recruitment motif, and/or formation of the CDKN1B ternary complex. Inhibited by INK4 family members. In resting cells, the non-tyrosine-phosphorylated form of CDKN1B prevents phosphorylation at Thr-172 and inactivation, while, in proliferating cells, tyrosine phosphorylation of CDKN1B allows phosphorylation of Thr-172 of CDK4 and subsequent activation.
messages: Component of the D-CDK4 complex, composed of CDK4 and some D-type G1 cyclin (CCND1, CCND2 or CCND3). Interacts directly in the complex with CCND1, CCND2 or CCND3. Interacts with SEI1 and ZNF655. Forms a ternary complex, cyclin D-CDK4-CDKN1B, involved in modulating CDK4 enzymatic activity. Interacts directly with CDKN1B (phosphorylated on 'Tyr-88' and 'Tyr-89'); the interaction allows assembly of the cyclin D-CDK4 complex, Thr-172 phosphorylation, nuclear translocation and enhances the cyclin D-CDK4 complex activity. CDK4 activity is either inhibited or enhanced depending on stoichiometry of complex. The non-tyrosine-phosphorylated form of CDKN1B prevents T-loop phosphorylation of CDK4 producing inactive CDK4. Interacts (unphosphorylated form) with CDK2. Also forms ternary complexes with CDKN1A or CDKN2A. Interacts directly with CDKN1A (via its N-terminal); the interaction promotes the assembly of the cyclin D-CDK4 complex, its nuclear translocation and promotes the cyclin D-dependent enzyme activity of CDK4. Interacts with CCND1; the interaction is prevented with the binding of CCND1 to INSM1 during cell cycle progression. Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23. Interacts with CEBPA (when phosphorylated). Interacts with FNIP1 and FNIP2.
messages: Cytoplasm
messages: Expressed in fetal and adult lung. Also expressed in brain, heart, liver, skeletal muscle and testes.
messages: In developing lung, high expression at day 17 after which levels decline to barely detectable levels at birth. Levels then increase postnatally until postnatal day 6 and decline in adulthood. Preferentially expressed in proliferating cells.
messages: Nucleus
messages: Nucleus membrane
messages: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

10116:Ppfibp2
gene id: 10116:Ppfibp2
uniprot id: A6I7S0
uniprot id: A6I7S1
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

10116:Marchf10
gene id: 10116:Marchf10
uniprot id: Q5XIV2
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
messages: The RING-CH-type zinc finger domain is required for E3 ligase activity.

10116:Yif1a
gene id: 10116:Yif1a
uniprot id: B0BMV4
uniprot id: F7F3S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

10116:Or1f19e
gene id: 10116:Or1f19e
uniprot id: M0R4Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Serpinh1
gene id: 10116:Serpinh1
uniprot id: A6I6G9
uniprot id: P29457
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
messages: By heat shock and retinoic acid.
messages: Endoplasmic reticulum lumen

10116:Kif3b
gene id: 10116:Kif3b
uniprot id: A6KHU9
uniprot id: D3ZI07
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

10116:Tuba4a
gene id: 10116:Tuba4a
uniprot id: A6JVZ9
uniprot id: Q5XIF6
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.
messages: Although this tubulin does not encode a C-terminal tyrosine, a C-terminal tyrosine can be added post-translationally by the tubulin tyrosine ligase (TTL). It can then undergo a detyrosination cycle by the tubulin tyrosine carboxypeptidase (KIAA0895L/MATCAP).
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with CFAP157 (By similarity).
messages: Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility.
messages: The MREC motif may be critical for tubulin autoregulation.
messages: This tubulin does not have a C-terminal tyrosine.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

10116:Xrcc2
gene id: 10116:Xrcc2
uniprot id: A6KJJ4
uniprot id: D3ZPC8
names: Subcellular Location Annotation
messages: Nucleus

10116:Cesl1
gene id: 10116:Cesl1
uniprot id: M0R7R1
uniprot id: Q63010
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Endoplasmic reticulum lumen
messages: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.
messages: Monomer.

10116:Necap2
gene id: 10116:Necap2
uniprot id: Q6P756
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NECAP family.
messages: Cell membrane
messages: Expressed in brain, heart, kidney, liver and lung (at protein level).
messages: Interacts with AP1G1 and AP2A1 components of the adapter protein complexes AP-1 and AP-2. Interacts with the GAE domain proteins GGA1, GGA2 and GGA3 (By similarity).
messages: Involved in endocytosis.
messages: The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity).
messages: clathrin-coated vesicle membrane

10116:Slc22a2
gene id: 10116:Slc22a2
uniprot id: A0A0G2JSP9
uniprot id: A6KJX5
uniprot id: Q9R0W2
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Basal cell membrane
messages: Basolateral cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Contains one proline-rich sequence (Pro-Glu-Ser-Pro-Arg) that may be involved in tyrosine-protein kinase YES1 binding and is required for the activation of substrate transport.
messages: Down-regulated in ischemia/reperfusion (I/R) kidneys (PubMed:18180268). Up-regulated by testosterone and moderately down-regulated by estradiol (PubMed:10812069).
messages: Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:9812985, PubMed:10889205, PubMed:12538837, PubMed:15817714, PubMed:16581093). Functions as a Na(+)-independent, bidirectional uniporter (By similarity). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (PubMed:10889205). However, may also engage electroneutral cation exchange when saturating concentrations of cation substrates are reached (PubMed:10889205). Predominantly expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow (By similarity). Implicated in monoamine neurotransmitters uptake such as histamine, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, serotonin and tyramine, thereby supporting a physiological role in the central nervous system by regulating interstitial concentrations of neurotransmitters (PubMed:9812985, PubMed:16581093). Also capable of transporting dopaminergic neuromodulators cyclo(his-pro), salsolinol and N-methyl-salsolinol, thereby involved in the maintenance of dopaminergic cell integrity in the central nervous system (By similarity). Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium (PubMed:15817714). Also transports guanidine and endogenous monoamines such as vitamin B1/thiamine, creatinine and N-1-methylnicotinamide (NMN) (PubMed:11758759). Mediates the uptake and efflux of quaternary ammonium compound choline (PubMed:10889205). Mediates the bidirectional transport of polyamine agmatine and the uptake of polyamine putrescine (PubMed:12538837). Able to transport non-amine endogenous compou…
messages: Expressed in the kidney, in the proximal tubules of cortex and of the outer medulla (PubMed:8702418, PubMed:9830022, PubMed:10812069, PubMed:11758759, PubMed:11083459, PubMed:16272756). In brain, highly expressed predominantly in regions located at the brain-cerebrospinal fluid border, in the leptomeninges, in the choroid plexus and in a layer boarding the third ventricle. In brain, also observed in the granular cell layer of the cerebellum and in the granular layer and pyramidal cells of the hippocampus in the CA1-CA3 regions (PubMed:16581093). Expressed in tracheal and bronchial ciliated epithelium in the respiratory tract (PubMed:15817714). Expression is greater in the kidney of male than of female (PubMed:16272756).
messages: Mediates the renal secretion of many clinically used cationic drugs (PubMed:16272756) (Probable). Transports drugs such as diabetes treatment medicine metformin and neurotoxins 1-methyl-4-phenylpyridinium (MPP(+)), famotidine, ranitidine, amantadine, acriflavine, amiloride, memantine, cimetidine, cisplatin, oxaliplatin, platinum-based drugs cisplatin and oxaliplatin, 3'-azido-3'-deoxythymidine (AZT) and tetraethylammonium (TEA) (PubMed:8702418, PubMed:11758759, PubMed:12538837, PubMed:16242669, PubMed:16272756, PubMed:16006492, PubMed:16581093). Mediates the bidirectional transport of MPP(+) (PubMed:9260930). Metformin competitively inhibits OCT1-mediated thiamine uptake, leading to a decrease in hepatic steatosis (By similarity). Plays a predominant role in the anticancer activity of cisplatin and oxaliplatin and may contribute to antitumor specificity (PubMed:17582384). Involved in cisplatin-induced nephrotoxicity (PubMed:16242669, PubMed:17582384).
messages: Tyrosine phosphorylated.
messages: Tyrosine phosphorylation of the transporter leads to activation of the transport activity. Inhibited by cGMP, most likely through a cGMP-binding protein that interacts with OCT2.
messages: While most authors have deduced a localization at the basolateral membrane of proximal tubules, other studies demonstrated a localization to the luminal membrane in the distal tubule.

10116:Cebpe
gene id: 10116:Cebpe
uniprot id: A6KGV9
uniprot id: P56261
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPA, CEBPB and CEBPD (PubMed:1884998). Interacts with GATA1 and SPI1 (By similarity). Interacts with SMARCD2 (By similarity).
messages: Nucleus
messages: Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation.

10116:Ly6i
gene id: 10116:Ly6i
uniprot id: Q63317
names: Subcellular Location Annotation
messages: Cell membrane

10116:Klhl22
gene id: 10116:Klhl22
uniprot id: A0A8L2QUL2
uniprot id: D3ZZC3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the BCR(KLHL22) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL22 and RBX1. Interacts with PLK1. Interacts with DEPDC5 (via DEP domain); the interaction depends on amino acid availability. Interacts with YWHAE; required for the nuclear localization of KLHL22 upon amino acid starvation.
messages: Lysosome
messages: Nucleus
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy.
messages: centrosome
messages: cytosol
messages: spindle

10116:Tyr
gene id: 10116:Tyr
uniprot id: A6I5Y6
uniprot id: D4A9G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

10116:Or12d2b
gene id: 10116:Or12d2b
uniprot id: Q6MFW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Or4e1
gene id: 10116:Or4e1
uniprot id: A6KEI3
uniprot id: D4AE91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Supt5h
gene id: 10116:Supt5h
uniprot id: A0A8I5ZQE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus

10116:Pik3cg
gene id: 10116:Pik3cg
uniprot id: D3ZFJ0
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

10116:Dok3
gene id: 10116:Dok3
uniprot id: B2RYG7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DOK family. Type A subfamily.
messages: Cell membrane
messages: Constitutively tyrosine-phosphorylated.
messages: Cytoplasm
messages: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).
messages: On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL1 kinase (By similarity).
messages: On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Binds ABL1 through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP (By similarity).
messages: PTB domain mediates receptor interaction.

10116:Dock11
gene id: 10116:Dock11
uniprot id: A0A0G2JV16
uniprot id: F1LQ91
names: Similarity
messages: Belongs to the DOCK family.

10116:Snurf
gene id: 10116:Snurf
uniprot id: Q9WU11
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNURF family.
messages: Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.
messages: Nucleus

10116:Tfpi2
gene id: 10116:Tfpi2
uniprot id: Q8CF99
names: Subcellular Location Annotation
messages: Secreted

10116:Bmp1
gene id: 10116:Bmp1
uniprot id: A6HTK6
uniprot id: F1M798
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Doxl2
gene id: 10116:Doxl2
uniprot id: Q6IMK5
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

10116:Acot2
gene id: 10116:Acot2
uniprot id: A0A8I6A1M5
uniprot id: A6JDS4
uniprot id: F7F6S1
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

10116:Psmb5
gene id: 10116:Psmb5
uniprot id: G3V7Q6
uniprot id: P28075
names: Function
names: Induction
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Down-regulated by theophylline (THP) and up-regulated by 1,3-dinitrobenzene (DNB), two reprotoxic agents thought to induce infertility.
messages: Nucleus
messages: Sequencing error.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Directly interacts with POMP. Interacts with ABCB1 and TAP1.

10116:Taar7e
gene id: 10116:Taar7e
uniprot id: F7F9J0
uniprot id: Q5QD19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

10116:Neurod6
gene id: 10116:Neurod6
uniprot id: A6K0Z6
uniprot id: F7FIW6
names: Subcellular Location Annotation
messages: Nucleus

10116:Adam7
gene id: 10116:Adam7
uniprot id: Q63180
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed specifically in the caput region of the epididymis (at protein level).
messages: Interacts with ITM2B in sperm; the interaction increases following capacitation (By similarity). Interacts with HSPA5 and CANX (By similarity).
messages: Membrane
messages: Required for normal male fertility via maintenance of epithelial cell morphology in the caput epididymis and subsequently correct epididymis lumen structure required for sperm development (By similarity). Plays a role in sperm motility, flagella morphology and tyrosine phosphorylation during sperm capacitance (By similarity). Plays a role in normal expression levels of HSPA5, ITM2B and ADAM2 in sperm both prior to and post-capacitation (By similarity). This is a non catalytic metalloprotease-like protein (By similarity).

10116:Cntnap4
gene id: 10116:Cntnap4
uniprot id: A6IZC7
uniprot id: F1M3J7
names: Caution
names: Similarity
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

10116:Abca2
gene id: 10116:Abca2
uniprot id: Q9ESR9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ABC transporter superfamily. ABCA family.
messages: Endosome membrane
messages: Expressed at high levels in brain, at moderate levels in heart, kidney and lung, and at low levels in skeletal muscle, stomach, spleen, colon and pancreas (PubMed:10970803). Not detected in the liver or small intestine (PubMed:10970803). In brain, highly expressed in white matter and detected in oligodendrocytes (PubMed:10970803, PubMed:11157071). Expressed in cerebellum as well as the anterior commissure (PubMed:11157071). Expressed mainly in the white matter but is also scattered in gray matter throughout the whole brain (PubMed:11157071). Expressed in myelinating cells of both ventral and dorsal restricted regions in newborn spinal cord (PubMed:12210128). Expressed in non-myelin-forming as well as in myelin-forming Schwann cells in the sciatic nerve (PubMed:17240058).
messages: Lysosome membrane
messages: Methylated at Gln-271 by N6AMT1.
messages: N-glycosylated.
messages: Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (By similarity). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926). May play a role in myelin formation (PubMed:12210128).
messages: Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development. May play a role in myelination, perhaps as a transporter for certain kinds of myelin chemical components (PubMed:12210128). May play an important role in gamma-secretase processing of APP and thus in amyloid-beta peptide generation (PubMed:22086926). Regulates esterification of plasma membrane cholesterol by modulation of sphingolipid metabolism (PubMed:24201375).

10116:Insig2
gene id: 10116:Insig2
uniprot id: Q80UA9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INSIG family.
messages: Binds oxysterols in a pocket within their transmembrane domains and interacts with SCAP via transmembrane domains 3 and 4.
messages: Endoplasmic reticulum membrane
messages: Interacts with SCAP; interaction is direct and only takes place in the presence of sterols; it prevents interaction between SCAP and the coat protein complex II (COPII). Associates with the SCAP-SREBP complex (composed of SCAP and SREBF1/SREBP1 or SREBF2/SREBP2); association is mediated via its interaction with SCAP and only takes place in the presence of sterols. Interacts with RNF139. Interacts with RNF145.
messages: Oxidized at Cys-215 in differentiated myotubes, preventing ubiquitination at the same site, and resulting in protein stabilization.
messages: Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi. Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2. Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139.
messages: Phosphorylation at Ser-151 by PCK1 reduces binding to oxysterol, disrupting the interaction between INSIG2 and SCAP, thereby promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes.
messages: Polyubiquitinated by AMFR/gp78 at Cys-215 in some tissues such as adipose tissues, undifferentiated myoblasts and liver, leading to its degradation. In differentiated myotubes, Cys-215 oxidation prevents ubiquitination at the same site, resulting in protein stabilization.
messages: The KxHxx motif mediates association with the coatomer complex.

10116:Ell2
gene id: 10116:Ell2
uniprot id: A0A8I6A5G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

10116:Smarcb1
gene id: 10116:Smarcb1
uniprot id: A6JKF4
uniprot id: Q4KLI0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF5 family.
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF.
messages: Nucleus

10116:S1pr5
gene id: 10116:S1pr5
uniprot id: A6JNQ5
uniprot id: Q9JKM5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found almost exclusively in brain and skin. Ubiquitously detected in different brain regions with very prominent expression in lower brain regions such as the midbrain, pons, medulla, and spinal cord. Expressed predominantly within white matter tracts of the brain. Corpus callosum, optic nerve, olfactory tract, anterior commissure, internal and external capsules, fimbra of the hippocampus, mammillary tract, stria medullaris, and white matter of the cerebellum and brain stem all express the receptor. Within the striatum itself white matter fascicles express the receptor. Detected also in spleen and lung. Not observed in heart, liver, skeletal muscle, kidney, or testes.
messages: In PC-12 cells, nerve growth factor induces neuronal differentiation and represses expression of the receptor. Down-regulated also by fibroblast growth factor and dibutyryl cAMP. Epidermal growth factor, an agent that does not induce differentiation, does not repress expression. Protein kinase A appears to be an obligatory cellular component in regulation.
messages: Membrane
messages: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/O)alpha and G(12) subclass of heteromeric G-proteins. Displays antiproliferative effects in transfected CHO-K1 and HEK293 cells.

10116:Acmsd
gene id: 10116:Acmsd
uniprot id: Q8R5M5
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Liver and kidney. Very low levels detected in brain.
messages: Monomer.

10116:Foxr1
gene id: 10116:Foxr1
uniprot id: F1LTW6
names: Subcellular Location Annotation
messages: Nucleus

10116:Rfc1
gene id: 10116:Rfc1
uniprot id: Q9Z2R7
names: Similarity
messages: Belongs to the activator 1 large subunit family.

10116:D2hgdh
gene id: 10116:D2hgdh
uniprot id: A0A8L2R544
uniprot id: A6JR40
uniprot id: B2GV75
uniprot id: P84850
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activated by zinc, cobalt and manganese ions (PubMed:15070399). Inhibited by EDTA (PubMed:15070399).
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate (PubMed:15070399). Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC) (PubMed:15070399). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC (By similarity).
messages: Mitochondrion

10116:Gle1
gene id: 10116:Gle1
uniprot id: A0A8I6A4N4
uniprot id: A6JTT7
uniprot id: Q4KLN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the NPC, however it may not be a stable component of the NPC complex since it shuttles between the nucleus and the cytoplasm. Interacts with nuclear pore complex proteins NUP155 and NUPL2 (By similarity).
messages: Belongs to the GLE1 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity).
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
messages: nuclear pore complex

10116:Phb2
gene id: 10116:Phb2
uniprot id: Q5XIH7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Cytoplasm
messages: In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan. The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner.Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity. Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6.
messages: In the nucleus, serves as transcriptional co-regulator. Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity.
messages: In the plasma membrane, is involved in IGFBP6-induced cell migration (By similarity). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).
messages: LC3-interaction region (LIR) is required for interaction with MAP1LC3B/LC3-II and for Parkin-mediated mitophagy.
messages: Mitochondrion inner membrane
messages: Nucleus
messages: Phosphorylated. Tyrosine phosphorylation is indirectly stimulated by IGFBP6.
messages: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus.
messages: The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2), assembled into a membrane-associated ring-shaped supercomplex of approximately 1 mDa (PubMed:11302691). Interacts with ESR1, HDAC1 and HDAC5 (By similarity). Interacts with ZNF703. Interacts with STOML2. Interacts with ARFGEF3 (By similarity). Interacts with SPHK2. Interacts with COX4I1; the interaction associates PHB2 with COX (By similarity). Interacts with MAP1LC3B (membrane-bound form LC3-II); the interaction is direct and upon mitochondrial depolarization and proteasome-dependent outer membrane rupture. Interacts with IGFBP6 (via C-terminal domain). Interacts with CLPB (By similarity). Interacts with CD86 (via cytoplasmic domain); the interactions increases after priming with CD40. Interacts with AFG3L2. Interacts with DNAJC19 (By similarity).

10116:Dclre1c
gene id: 10116:Dclre1c
uniprot id: Q5XIX3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Interacts with ATM, BRCA1, PRKDC and TP53BP1. Also exhibits ATM- and phosphorylation-dependent interaction with the MRN complex, composed of MRE11, RAD50, and NBN (By similarity).
messages: Nucleus
messages: Phosphorylation on undefined residues by PRKDC may stimulate endonucleolytic activity on 5' and 3' hairpins and overhangs. PRKDC must remain present, even after phosphorylation, for efficient hairpin opening. Also phosphorylated by ATM in response to ionizing radiation (IR) and by ATR in response to ultraviolet (UV) radiation (By similarity).
messages: Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation, and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (By similarity).

10116:Sult1b1
gene id: 10116:Sult1b1
uniprot id: P52847
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family.
messages: Cytoplasm
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:12773305, PubMed:8530477). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (By similarity).
messages: The N-terminus is blocked.

10116:Cd40
gene id: 10116:Cd40
uniprot id: A0A8I5XVD8
uniprot id: A0A8I6A2T5
uniprot id: A0A8I6AHI1
uniprot id: A6JXD6
uniprot id: A6JXD8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

10116:Ttc9
gene id: 10116:Ttc9
uniprot id: A6JDN6
names: Similarity
messages: Belongs to the TTC9 family.

10116:Gata1
gene id: 10116:Gata1
uniprot id: A6KP60
uniprot id: P43429
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated at 2 conserved lysine-rich motifs by CREBBP in vitro. Acetylation does not affect DNA-binding in vitro but is essential to induce erythroid differentiation and for binding chromatin in vivo. Acetylated on Lys-233, Lys-245 Lys-246 by EP300 (By similarity).
messages: Erythrocytes, and fetal hepatocytes.
messages: Highly phosphorylated on serine residues. Phosphorylation on Ser-310 is enhanced on erythroid differentiation. Phosphorylation on Ser-142 promotes sumoylation on Lys-137 (By similarity).
messages: Interacts (via the N-terminal zinc finger) with ZFPM1. Interacts with GFI1B. Interacts with PIAS4; the interaction enhances sumoylation and represses the transactivational activity in a sumoylation-independent manner. Interacts with LMCD1. Interacts with BRD3 (By similarity). Interacts with CREBBP; the interaction stimulates acetylation and transcriptional activity in vivo. Interacts with MED1, CCAR1 and CALCOCO1 (By similarity). Interacts with EP300 (By similarity). Interacts with CEBPE (By similarity).
messages: Nucleus
messages: Sumoylation on Lys-137 is enhanced by phosphorylation on Ser-142 and by interaction with PIAS4. Sumoylation with SUMO1 has no effect on transcriptional activity (By similarity).
messages: The two fingers are functionally distinct and cooperate to achieve specific, stable DNA binding. The first finger is necessary only for full specificity and stability of binding, whereas the second one is required for binding (By similarity).
messages: Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS.

10116:Ddx27
gene id: 10116:Ddx27
uniprot id: B1H269
names: Similarity
messages: Belongs to the DEAD box helicase family.

10116:Acot13
gene id: 10116:Acot13
uniprot id: A6KLF5
uniprot id: D3ZA93
names: Similarity
messages: Belongs to the thioesterase PaaI family.

10116:Irf5
gene id: 10116:Irf5
uniprot id: A6IEE2
uniprot id: D3ZPU1
names: Subcellular Location Annotation
messages: Nucleus

10116:Agpat3
gene id: 10116:Agpat3
uniprot id: A6JK33
uniprot id: G3V648
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

10116:Dtymk
gene id: 10116:Dtymk
uniprot id: A6JR35
names: Similarity
messages: Belongs to the thymidylate kinase family.

10116:RGD1562462
gene id: 10116:RGD1562462
uniprot id: A0A8I6AFY0
names: Similarity
messages: Belongs to the HIN-200 family.

10116:Mettl6
gene id: 10116:Mettl6
uniprot id: A6KFY8
uniprot id: Q6AXU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. METL family.
messages: Cytoplasm
messages: Monomer. Interacts with SARS1/SerRS; interaction is mediated via tRNA(Ser) and is required for N(3)-methylcytidine methylation.
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU). Interaction with SARS1/SerRS is required for N(3)-methylcytidine methylation.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

10116:Fam53b
gene id: 10116:Fam53b
uniprot id: A6HWZ9
uniprot id: A6HX00
uniprot id: D3Z8Z2
names: Similarity
messages: Belongs to the FAM53 family.

10116:RT1-M3-1
gene id: 10116:RT1-M3-1
uniprot id: A0A8I5ZTS2
uniprot id: A6KR51
uniprot id: G3V627
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Membrane

10116:Elk1
gene id: 10116:Elk1
uniprot id: A4GTP4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETS family.
messages: Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity. Interacts with MAD2L2; the interaction is direct and promotes phosphorylation by the kinases MAPK8 and/or MAPK9. Interacts with POU1F1.
messages: Nucleus
messages: On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-382 and Ser-388 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-382 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14 (By similarity). Upon bFGF stimulus, phosphorylated by PAK1 (PubMed:17156131).
messages: Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.
messages: Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (By similarity) (PubMed:17156131). Induces target gene transcription upon JNK-signaling pathway stimulation (PubMed:17156131).

10116:Or52a5
gene id: 10116:Or52a5
uniprot id: A6I7B3
uniprot id: D3ZNE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Cyc1
gene id: 10116:Cyc1
uniprot id: A6HS83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Membrane
messages: Mitochondrion inner membrane

10116:Rbp4
gene id: 10116:Rbp4
uniprot id: B2RZC1
uniprot id: P04916
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Detected in blood plasma (at protein level).
messages: Interacts with TTR (PubMed:4708098). Interaction with TTR prevents its loss by filtration through the kidney glomeruli (Probable). Interacts with STRA6 (By similarity).
messages: Interacts with TTR.
messages: Retinol-binding protein that mediates retinol transport in blood plasma.
messages: Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues (PubMed:4708098). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (By similarity).
messages: Secreted

10116:Mmel1
gene id: 10116:Mmel1
uniprot id: A6IUM5
names: Subcellular Location Annotation
messages: Membrane

10116:Chchd6
gene id: 10116:Chchd6
uniprot id: D4A7N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with DISC1. Interacts with IMMT/MIC60.
messages: Mitochondrion
messages: Mitochondrion inner membrane

10116:Cyp11b3
gene id: 10116:Cyp11b3
uniprot id: Q64539
names: Similarity
messages: Belongs to the cytochrome P450 family.

10116:Anp32e
gene id: 10116:Anp32e
uniprot id: Q5XIE0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ANP32 family.
messages: Component of a SWR1-like complex, composed of EP400, KAT5/TIP60, TRRAP, BRD8, RUVBL1, RUVBL2, ING3 and ANP32E; the complex does not contain SRCAP. Interacts with H2A.Z/H2AZ1. Interacts with the importin alpha KPNA1 and KPNA2 (By similarity).
messages: Cytoplasm
messages: Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis (By similarity).
messages: Nucleus
messages: Phosphorylated. The phosphorylation is nuclear localization signal (NLS)-dependent (By similarity).
messages: The H2A.Z-interacting domain (ZID) mediates a direct interaction with H2A.Z/H2AZ1.

10116:Rpl27
gene id: 10116:Rpl27
uniprot id: A6HJB9
uniprot id: P61354
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Component of the large ribosomal subunit (By similarity). Interacts with RRP1B (By similarity). Component of the large ribosomal subunit. Interacts with RRP1B. Interacts with DHX33 (By similarity).
messages: Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

10116:Gstt2
gene id: 10116:Gstt2
uniprot id: B6DYQ9
uniprot id: P30713
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the GST superfamily. Theta family.
messages: Catalyzes the inactivation of reactive sulfate esters in carcinogenic arylmethanols (PubMed:2114406). Highest activity towards ethacrynic acid and cumene hydroperoxide (PubMed:2114406).
messages: Highest values found in liver followed by testis, adrenal gland, kidney, lung, brain and skeletal muscle. In liver, highest expression found in central vein limiting plate hepatocytes. In lung, expressed mainly in club cells of the bronchiolar epithelium and, at low levels, in type II alveolar cells.
messages: Homodimer.
messages: Nucleus
messages: cytosol

10116:Plscr3
gene id: 10116:Plscr3
uniprot id: Q6QBQ4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholipid scramblase family.
messages: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (PubMed:29171872). Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response (By similarity). Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis (By similarity). Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases (By similarity). Regulates cardiolipin de novo biosynthesis and its resynthesis (By similarity).
messages: Mitochondrion inner membrane
messages: Monomer (By similarity). Forms homooligomers upon binding to Ca(2+), Pb(2+) and Hg(2+) ions (By similarity). Interacts with PDCD6 in a calcium-dependent manner (By similarity). Interacts with PRKCD; interaction is enhanced by UV irradiation (By similarity).
messages: Nucleus
messages: Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus.
messages: The Proline-rich domain is required for phospholipid scramblase activity.

10116:Elavl4
gene id: 10116:Elavl4
uniprot id: A0A8I6APY9
uniprot id: B0BMT8
uniprot id: O09032
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RRM elav family.
messages: Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP (By similarity). Associates with the EIF4F cap-binding complex, composed of EIF4G, EIF4A, EIF4E and PABP (By similarity). Within the EIF4F cap-binding complex, interacts with EIF4A (By similarity). Interacts with SMN (via Tudor domain) in an RNA-independent manner; the interaction is required for localization of ELAVL4 to RNA granules (PubMed:21389246). Interacts with MAP1 light chain LC1 (via C-terminus); the interaction contributes to the association of ELAVL4 with microtubules (By similarity). Interacts with MAP1 light chain LC2 (By similarity).
messages: Cytoplasm
messages: Expressed in the hippocampus and cerebral cortex (at protein level) (PubMed:15519747). Expressed in stem and progenitor cells in the subventricular zone of the hippocampus (at protein level) (PubMed:16554442). Expressed in hippocampal neurons, with highest levels of expression in the CA4 and CA3 neurons and lower levels in CA1 neurons (at protein level) (PubMed:11948657, PubMed:17577668, PubMed:25692578). Expressed in the dorsal root ganglion (at protein level) (PubMed:12957493). Expressed in the superior cervical ganglion (PubMed:17234598).
messages: Expression in dentate granule cells of the hippocampus at postnatal day 7, with disappearing expression in dentate granule cells as early as P14.
messages: Faster decay of GAP42 mRNA.
messages: Methylated by CARM1, which leads to reduced RNA-binding activity and enhanced interaction with SMN (By similarity). Methylation at Arg-248 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state (PubMed:16508003). Methylation is inhibited by NGF, which facilitates neurite outgrowth (PubMed:16508003).
messages: Perikaryon
messages: RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:10982410, PubMed:16508003, PubMed:17577668). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:10982410, PubMed:16508003, PubMed:17577668). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (PubMed:10982410). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (By similarity). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (By similarity). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (By similarity). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:10982410, PubMed:17577668). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (By similarity). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (By similarity). Binds and stabilizes MSI1 mRNA in neural stem cells (By similarity). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (By similarity). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (PubMed:16508003). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (By similarity). …
messages: The RRM 3 domain is required for binding to poly(A) RNA, for the association with polysomes and with the EIF4F cap-binding complex and for the stimulation of translation (By similarity). The RRM 1 and RRM 2 domains may contribute to polysome association and stimulation of translation (By similarity).
messages: Up-regulated by kainic acid-induced seizures (PubMed:17577668). Up-regulated after contextual fear conditioning (PubMed:15519747). Down-regulated at day 2 after axotomy and up-regulated at day 7 after axotomy (PubMed:17234598, PubMed:12957493).
messages: axon
messages: dendrite
messages: growth cone

10116:Gnat1
gene id: 10116:Gnat1
uniprot id: A6I307
uniprot id: D3ZSS5
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

10116:Psmc2
gene id: 10116:Psmc2
uniprot id: Q63347
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC2 and few additional components. Interacts with NDC80 and SQSTM1. Interacts with PAAF1. Interacts with TRIM5.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm
messages: Monoubiquitinated by RNF181.
messages: Phosphorylated. Dephosphorylated by UBLCP1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly.

10116:Basp1
gene id: 10116:Basp1
uniprot id: Q05175
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the BASP1 family.
messages: Brain.
messages: Cell membrane
messages: growth cone

10116:Ppp1r1b
gene id: 10116:Ppp1r1b
uniprot id: A0A8I6GL91
uniprot id: Q6J4I0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein phosphatase inhibitor 1 family.
messages: Cytoplasm
messages: Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.
messages: Inhibitor of protein-phosphatase 1.
messages: Phosphorylation of Thr-34 is required for activity.

10116:Or4c124
gene id: 10116:Or4c124
uniprot id: A0A8I6A622
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

10116:Usp14
gene id: 10116:Usp14
uniprot id: Q5U2N2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS.

10116:Ypel1
gene id: 10116:Ypel1
uniprot id: A6JSN7
names: Similarity
messages: Belongs to the yippee family.

10116:Slc1a3
gene id: 10116:Slc1a3
uniprot id: A0A0G2JSU1
uniprot id: A0A0G2K611
uniprot id: A0A0G2KAS7
uniprot id: A6KGI5
uniprot id: A6KGI6
uniprot id: G3V846
uniprot id: P24942
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A3 subfamily.
messages: Cell membrane
messages: Contains eight transmembrane regions plus two helical hairpins that dip into the membrane. These helical hairpin structures play an important role in the transport process. The first enters the membrane from the cytoplasmic side, the second one from the extracellular side. During the transport cycle, the regions involved in amino acid transport, and especially the helical hairpins, move vertically by about 15-18 Angstroms, alternating between exposure to the aqueous phase and reinsertion in the lipid bilayer. In contrast, the regions involved in trimerization do not move.
messages: Detected in brain and cerebellum (PubMed:1279699, PubMed:8387171). Both isoform GLAST-1 and GLAST-1A are expressed in bone and brain (PubMed:11086157). In brain isoform GLAST-1 is highly enriched in the Purkinje cell layer in cerebellum (PubMed:11086157).
messages: Glycosylated.
messages: Homotrimer (By similarity).
messages: Membrane
messages: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:1279699, PubMed:8387171). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity).

10116:Zdhhc1
gene id: 10116:Zdhhc1
uniprot id: Q2TGK5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

10116:Saxo1
gene id: 10116:Saxo1
uniprot id: A6J863
uniprot id: M0R6K6
names: Similarity
messages: Belongs to the FAM154 family.

10116:Cacna1h
gene id: 10116:Cacna1h
uniprot id: Q9EQ60
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1H subfamily.
messages: Cell membrane
messages: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
messages: Expressed in brain.
messages: In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.
messages: Interacts (via N-terminal cytoplasmic domain) with STAC.
messages: Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:11073957). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (By similarity).

10116:Uqcc4
gene id: 10116:Uqcc4
uniprot id: A6HD03
uniprot id: D4ACY1
names: Similarity
messages: Belongs to the UQCC4 family.

10116:Ssx2ip
gene id: 10116:Ssx2ip
uniprot id: A6HWD4
uniprot id: Q8CGZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (PubMed:12446711). Involved in ciliogenesis (By similarity). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (By similarity).
messages: Belongs to the ADIP family.
messages: Interacts with SSX2 and SSX3 (By similarity). Does not interact with SSX1 and SSX4. Interacts with VAV2 (By similarity). Interacts with afadin and alpha-actinin (PubMed:12446711). Interacts with WRAP73 (By similarity).
messages: Nucleus
messages: adherens junction
messages: centriolar satellite
messages: cilium basal body

10116:Snx14
gene id: 10116:Snx14
uniprot id: A6I1Y0
names: Similarity
messages: Belongs to the sorting nexin family.

10116:Maip1
gene id: 10116:Maip1
uniprot id: Q6AY04
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with AFG3L2. Interacts with SPG7. Interacts with SMDT1/EMRE (via the N-terminal transit peptide); interaction is direct and takes place before maturation of SMDT1/EMRE.
messages: Mitochondrion matrix
messages: Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB).

10116:Cldn4
gene id: 10116:Cldn4
uniprot id: F7FBN1
uniprot id: Q5XIT8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

10116:Fbxo43
gene id: 10116:Fbxo43
uniprot id: Q66H04
names: Function
names: PTM
names: Subunit
messages: Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interaction with SKP1 does not occur. Interacts with ANAPC2; the interaction is direct, ANAPC4, CDC16, CDC23; the interaction is direct; ANAPC10; the interaction is direct and CDC26, during spermatogenesis (By similarity). Interacts with CDC20 (By similarity).
messages: Phosphorylated on Thr-190 and Ser-289 in response to calcium, which is a prerequisite for ubiquitination and proteasomal degradation.
messages: Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (By similarity). Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis.
messages: Ubiquitinated in response to calcium, which promotes proteasomal degradation.

10116:Ogfr
gene id: 10116:Ogfr
uniprot id: Q3MID9
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

10116:Ctdnep1
gene id: 10116:Ctdnep1
uniprot id: Q3B7T6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dullard family.
messages: Endoplasmic reticulum membrane
messages: Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2.
messages: Nucleus membrane
messages: Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling (By similarity).